- Tytuł:
- Proline based rationally designed peptide esters against dipeptidyl peptidase-4: Highly potent anti-diabetic agents.
- Autorzy:
- Źródło:
- Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2022 Nov 15; Vol. 76, pp. 129018. Date of Electronic Publication: 2022 Oct 06.
- Typ publikacji:
- Journal Article; Research Support, Non-U.S. Gov't
- MeSH Terms:
-
Dipeptidyl-Peptidase IV Inhibitors*/
chemical synthesis
Dipeptidyl-Peptidase IV Inhibitors*/chemistry
Dipeptidyl-Peptidase IV Inhibitors*/pharmacology
Hypoglycemic Agents*/chemical synthesis
Hypoglycemic Agents*/chemistry
Hypoglycemic Agents*/pharmacology
Oligopeptides*/chemical synthesis
Oligopeptides*/chemistry
Oligopeptides*/pharmacology
Drug Design*
Blood Glucose/metabolism ; Esters/chemical synthesis ; Esters/chemistry ; Esters/pharmacology ; Gastric Inhibitory Polypeptide/metabolism ; Glucagon-Like Peptide 1/metabolism ; Proline/chemistry ; Sitagliptin Phosphate/chemistry ; Sitagliptin Phosphate/pharmacology