Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Wyszukujesz frazę ""CHEMICAL synthesis"" wg kryterium: Temat


Starter badań:

Tytuł:
Proline based rationally designed peptide esters against dipeptidyl peptidase-4: Highly potent anti-diabetic agents.
Autorzy:
Vivesh; Department of Chemistry, UGC Sponsored Centre for Advanced Studies, Guru Nanak Dev University, Amritsar 143005, India.
Kaur B; Department of Chemistry, UGC Sponsored Centre for Advanced Studies, Guru Nanak Dev University, Amritsar 143005, India.
Jaglan S; Department of Chemistry, UGC Sponsored Centre for Advanced Studies, Guru Nanak Dev University, Amritsar 143005, India.
Rani S; Department of Chemistry, UGC Sponsored Centre for Advanced Studies, Guru Nanak Dev University, Amritsar 143005, India.
Batra Y; Department of Chemistry, UGC Sponsored Centre for Advanced Studies, Guru Nanak Dev University, Amritsar 143005, India.
Singh P; Department of Chemistry, UGC Sponsored Centre for Advanced Studies, Guru Nanak Dev University, Amritsar 143005, India. Electronic address: .
Pokaż więcej
Źródło:
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2022 Nov 15; Vol. 76, pp. 129018. Date of Electronic Publication: 2022 Oct 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Dipeptidyl-Peptidase IV Inhibitors*/chemical synthesis
Dipeptidyl-Peptidase IV Inhibitors*/chemistry
Dipeptidyl-Peptidase IV Inhibitors*/pharmacology
Hypoglycemic Agents*/chemical synthesis
Hypoglycemic Agents*/chemistry
Hypoglycemic Agents*/pharmacology
Oligopeptides*/chemical synthesis
Oligopeptides*/chemistry
Oligopeptides*/pharmacology
Drug Design*
Blood Glucose/metabolism ; Esters/chemical synthesis ; Esters/chemistry ; Esters/pharmacology ; Gastric Inhibitory Polypeptide/metabolism ; Glucagon-Like Peptide 1/metabolism ; Proline/chemistry ; Sitagliptin Phosphate/chemistry ; Sitagliptin Phosphate/pharmacology
Czasopismo naukowe
Tytuł:
Synthesis of meta-substituted arene bioisosteres from [3.1.1]propellane.
Autorzy:
Frank N; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.
Nugent J; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.
Shire BR; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.
Pickford HD; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.
Rabe P; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.
Sterling AJ; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.
Zarganes-Tzitzikas T; Alzheimer's Research UK Oxford Drug Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, Oxford, UK.
Grimes T; Alzheimer's Research UK Oxford Drug Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, Oxford, UK.
Thompson AL; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.
Smith RC; Abbvie Drug Discovery Science & Technology (DDST), North Chicago, IL, USA.
Schofield CJ; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.
Brennan PE; Alzheimer's Research UK Oxford Drug Discovery Institute, Centre for Medicines Discovery, Nuffield Department of Medicine, Oxford, UK.
Duarte F; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.
Anderson EA; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK. .
Pokaż więcej
Źródło:
Nature [Nature] 2022 Nov; Vol. 611 (7937), pp. 721-726. Date of Electronic Publication: 2022 Sep 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Drug Design*
Bridged Bicyclo Compounds*/chemical synthesis
Bridged Bicyclo Compounds*/chemistry
Heptanes*/chemical synthesis
Heptanes*/chemistry
Anions/chemistry ; Benzene/chemistry ; Solubility ; Drug Discovery ; Pentanes/chemical synthesis ; Pentanes/chemistry
Czasopismo naukowe
Tytuł:
Self-assembly of emulsion droplets through programmable folding.
Autorzy:
McMullen A; Center for Soft Matter Research, New York University, New York, NY, USA.
Muñoz Basagoiti M; Gulliver UMR CNRS 7083, ESPCI Paris, Université PSL, Paris, France.
Zeravcic Z; Gulliver UMR CNRS 7083, ESPCI Paris, Université PSL, Paris, France. .
Brujic J; Center for Soft Matter Research, New York University, New York, NY, USA. .; PMMH UMR CNRS 7636, ESPCI Paris, Université PSL, Paris, France. .
Pokaż więcej
Źródło:
Nature [Nature] 2022 Oct; Vol. 610 (7932), pp. 502-506. Date of Electronic Publication: 2022 Sep 28.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Polymers*/chemical synthesis
Polymers*/chemistry
Materials Science*/methods
DNA/chemistry ; Emulsions/chemical synthesis ; Emulsions/chemistry ; Colloids/chemical synthesis ; Colloids/chemistry
Czasopismo naukowe
Tytuł:
Identification of novel indole derivatives as highly potent and efficacious LSD1 inhibitors.
Autorzy:
Zhang X; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, PR China; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
Sun Y; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, PR China.
Huang H; Department of Physiology, Life Science and Biopharmaceutical Institution, Shenyang Pharmaceutical University, Shenyang, China.
Wang X; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, PR China; School of Chinese Materia Medica, Beijing University of Chinese Medicine, Chaoyang District, Beijing, 102488, China.
Wu T; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, PR China.
Yin W; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, PR China.
Li X; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, PR China.
Wang L; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, PR China.
Gu Y; Department of Physiology, Life Science and Biopharmaceutical Institution, Shenyang Pharmaceutical University, Shenyang, China. Electronic address: .
Zhao D; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, PR China. Electronic address: .
Cheng M; Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, Liaoning, PR China.
Pokaż więcej
Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2022 Sep 05; Vol. 239, pp. 114523. Date of Electronic Publication: 2022 Jun 10.
Typ publikacji:
Journal Article
MeSH Terms:
Enzyme Inhibitors*/chemical synthesis
Enzyme Inhibitors*/pharmacology
Histone Demethylases*/antagonists & inhibitors
Indoles*/chemical synthesis
Indoles*/pharmacology
A549 Cells ; Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/pharmacology ; Apoptosis ; Humans ; Male ; Mice, Inbred BALB C ; Models, Molecular ; Molecular Docking Simulation ; Molecular Structure ; Rats, Sprague-Dawley ; Structure-Activity Relationship ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł:
Site-selective, stereocontrolled glycosylation of minimally protected sugars.
Autorzy:
Li Q; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Levi SM; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Wagen CC; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Wendlandt AE; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Jacobsen EN; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA. .
Pokaż więcej
Źródło:
Nature [Nature] 2022 Aug; Vol. 608 (7921), pp. 74-79. Date of Electronic Publication: 2022 Jun 16.
Typ publikacji:
Journal Article
MeSH Terms:
Chemistry Techniques, Synthetic*
Glycosylation*
Sugars*/chemical synthesis
Sugars*/chemistry
Catalysis ; Disaccharides/chemical synthesis ; Disaccharides/chemistry ; Kinetics ; Monosaccharides/chemical synthesis ; Monosaccharides/chemistry ; Stereoisomerism
Czasopismo naukowe
Tytuł:
Exploring the Synthetic Potential of γ-Lactam Derivatives Obtained from a Multicomponent Reaction-Applications as Antiproliferative Agents.
Autorzy:
López-Francés A; Departamento de Química Orgánica I, Centro de Investigación y Estudios Avanzados 'Lucio Lascaray', Facultad de Farmacia, University of the Basque Country, UPV/EHU Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, Spain.
Del Corte X; Departamento de Química Orgánica I, Centro de Investigación y Estudios Avanzados 'Lucio Lascaray', Facultad de Farmacia, University of the Basque Country, UPV/EHU Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, Spain.
Serna-Burgos Z; Departamento de Química Orgánica I, Centro de Investigación y Estudios Avanzados 'Lucio Lascaray', Facultad de Farmacia, University of the Basque Country, UPV/EHU Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, Spain.
Martínez de Marigorta E; Departamento de Química Orgánica I, Centro de Investigación y Estudios Avanzados 'Lucio Lascaray', Facultad de Farmacia, University of the Basque Country, UPV/EHU Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, Spain.
Palacios F; Departamento de Química Orgánica I, Centro de Investigación y Estudios Avanzados 'Lucio Lascaray', Facultad de Farmacia, University of the Basque Country, UPV/EHU Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, Spain.
Vicario J; Departamento de Química Orgánica I, Centro de Investigación y Estudios Avanzados 'Lucio Lascaray', Facultad de Farmacia, University of the Basque Country, UPV/EHU Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, Spain.
Pokaż więcej
Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Jun 05; Vol. 27 (11). Date of Electronic Publication: 2022 Jun 05.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/chemical synthesis
Antineoplastic Agents*/pharmacology
Lactams*/chemical synthesis
Lactams*/chemistry
beta-Lactams/*chemical synthesis
Cycloaddition Reaction ; Imines ; Stereoisomerism ; beta-Lactams/chemistry
Czasopismo naukowe
Tytuł:
Isatin thiazoles as antidiabetic: Synthesis, in vitro enzyme inhibitory activities, kinetics, and in silico studies.
Autorzy:
Solangi M; International Center for Chemical and Biological Sciences, H. E. J. Research Institute of Chemistry, University of Karachi, Karachi, Pakistan.
Kanwal; International Center for Chemical and Biological Sciences, H. E. J. Research Institute of Chemistry, University of Karachi, Karachi, Pakistan.; Institute of Marine Biotechnology, Universiti Malaysia Terengannu, Kuala Terengganu, Terengganu, Malaysia.
Khan KM; International Center for Chemical and Biological Sciences, H. E. J. Research Institute of Chemistry, University of Karachi, Karachi, Pakistan.; Department of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Chigurupati S; Department of Medicinal Chemistry and Pharmacognosy, Qassim University, Buraydah, Saudi Arabia.
Saleem F; International Center for Chemical and Biological Sciences, H. E. J. Research Institute of Chemistry, University of Karachi, Karachi, Pakistan.
Qureshi U; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.
Ul-Haq Z; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.
Jabeen A; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.
Felemban SG; Department of Medical Laboratory Science, Fakeeh College for Medical Sciences, Jeddah, Kingdom of Saudi Arabia.
Zafar F; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.
Perveen S; PCSIR Laboratories Complex, Shahrah-e-Dr. Salimuzzaman Siddiqui, Karachi, Pakistan.
Taha M; Department of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Bhatia S; Natural and Medical Sciences Research Center, University of Nizwa, Nizwa, Oman.
Pokaż więcej
Źródło:
Archiv der Pharmazie [Arch Pharm (Weinheim)] 2022 Jun; Vol. 355 (6), pp. e2100481. Date of Electronic Publication: 2022 Mar 30.
Typ publikacji:
Journal Article
MeSH Terms:
Hypoglycemic Agents*/chemical synthesis
Hypoglycemic Agents*/pharmacology
Isatin*/chemical synthesis
Isatin*/pharmacology
Thiazoles*/chemical synthesis
Thiazoles*/pharmacology
Diabetes Mellitus ; Glycoside Hydrolase Inhibitors/chemical synthesis ; Glycoside Hydrolase Inhibitors/pharmacology ; Humans ; Kinetics ; Molecular Docking Simulation ; Molecular Structure ; Structure-Activity Relationship ; alpha-Amylases/antagonists & inhibitors ; alpha-Glucosidases/metabolism
Czasopismo naukowe
Tytuł:
Akkermansia muciniphila phospholipid induces homeostatic immune responses.
Autorzy:
Bae M; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Blavatnik Institute, Boston, MA, USA.; College of Pharmacy, Gachon University, Incheon, South Korea.
Cassilly CD; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Blavatnik Institute, Boston, MA, USA.
Liu X; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Blavatnik Institute, Boston, MA, USA.; Department of Cancer Biology and the Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Park SM; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Tusi BK; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Chen X; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Kwon J; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Blavatnik Institute, Boston, MA, USA.; Natural Product Informatics Research Center, Korea Institute of Science and Technology (KIST), Ganeung, South Korea.
Filipčík P; Biochemistry Department, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.; SBGrid Consortium, Harvard Medical School, Blavatnik Institute, Boston, MA, USA.
Bolze AS; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Liu Z; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Vlamakis H; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Graham DB; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Buhrlage SJ; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Blavatnik Institute, Boston, MA, USA.; Department of Cancer Biology and the Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Xavier RJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA. .; Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. .; Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. .
Clardy J; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Blavatnik Institute, Boston, MA, USA. jon_.
Pokaż więcej
Źródło:
Nature [Nature] 2022 Aug; Vol. 608 (7921), pp. 168-173. Date of Electronic Publication: 2022 Jul 27.
Typ publikacji:
Journal Article
MeSH Terms:
Akkermansia*/chemistry
Akkermansia*/cytology
Akkermansia*/immunology
Homeostasis*/immunology
Immunity*
Phosphatidylethanolamines*/chemical synthesis
Phosphatidylethanolamines*/chemistry
Phosphatidylethanolamines*/immunology
Cell Membrane/chemistry ; Cell Membrane/immunology ; Cytokines/immunology ; Humans ; Inflammation Mediators/chemical synthesis ; Inflammation Mediators/chemistry ; Inflammation Mediators/immunology ; Structure-Activity Relationship ; Toll-Like Receptor 1/immunology ; Toll-Like Receptor 2/agonists ; Toll-Like Receptor 2/immunology
SCR Organism:
Akkermansia muciniphila
Czasopismo naukowe
Tytuł:
Synthesis of silver nanoparticle-decorated hydroxyapatite nanocomposite with combined bioactivity and antibacterial properties.
Autorzy:
Bee SL; School of Materials and Mineral Resources Engineering, Engineering Campus, Universiti Sains Malaysia, 14300, Nibong Tebal, Penang, Malaysia. .
Bustami Y; School of Biological Sciences, Universiti Sains Malaysia, 11800, Pulau Pinang, Malaysia.
Ul-Hamid A; Center for Engineering Research, Research Institute, King Fahd University of Petroleum & Minerals, Dhahran, 31261, Saudi Arabia.
Lim K; School of Materials and Mineral Resources Engineering, Engineering Campus, Universiti Sains Malaysia, 14300, Nibong Tebal, Penang, Malaysia.
Abdul Hamid ZA; School of Materials and Mineral Resources Engineering, Engineering Campus, Universiti Sains Malaysia, 14300, Nibong Tebal, Penang, Malaysia. .
Pokaż więcej
Źródło:
Journal of materials science. Materials in medicine [J Mater Sci Mater Med] 2021 Aug 23; Vol. 32 (9), pp. 106. Date of Electronic Publication: 2021 Aug 23.
Typ publikacji:
Journal Article
MeSH Terms:
Anti-Bacterial Agents*/chemical synthesis
Anti-Bacterial Agents*/chemistry
Anti-Bacterial Agents*/pharmacology
Coated Materials, Biocompatible/*chemical synthesis
Metal Nanoparticles/*chemistry
Silver/*chemistry
Animals ; Bone Substitutes/chemical synthesis ; Bone Substitutes/chemistry ; Bone Substitutes/pharmacology ; Chickens ; Coated Materials, Biocompatible/chemistry ; Coated Materials, Biocompatible/pharmacology ; Durapatite/chemistry ; Durapatite/pharmacology ; Materials Testing ; Microbial Sensitivity Tests ; Microscopy, Electron, Transmission ; Nanocomposites/chemistry ; Prostheses and Implants ; Silver/pharmacology ; Staphylococcus aureus/drug effects ; Staphylococcus aureus/growth & development
Czasopismo naukowe
Tytuł:
Tunable and high tissue adhesive properties of injectable chitosan based hydrogels through polymer architecture modulation.
Autorzy:
Jung HY; Department of Molecular Science and Technology, Ajou University, 5 Woncheon, Yeongtong, Suwon, 443-749, Republic of Korea. Electronic address: .
Le Thi P; Department of Molecular Science and Technology, Ajou University, 5 Woncheon, Yeongtong, Suwon, 443-749, Republic of Korea. Electronic address: .
HwangBo KH; Department of Material Development, GENOSS, 906-5 Iuidong, Yeongtong, Suwon, Republic of Korea. Electronic address: .
Bae JW; Department of Material Development, GENOSS, 906-5 Iuidong, Yeongtong, Suwon, Republic of Korea. Electronic address: .
Park KD; Department of Molecular Science and Technology, Ajou University, 5 Woncheon, Yeongtong, Suwon, 443-749, Republic of Korea. Electronic address: .
Pokaż więcej
Źródło:
Carbohydrate polymers [Carbohydr Polym] 2021 Jun 01; Vol. 261, pp. 117810. Date of Electronic Publication: 2021 Feb 14.
Typ publikacji:
Journal Article
MeSH Terms:
Tissue Adhesives*/administration & dosage
Tissue Adhesives*/chemical synthesis
Tissue Adhesives*/chemistry
Tissue Adhesives*/pharmacology
Chitosan/*chemistry
Hydrogels/*chemical synthesis
Adhesiveness ; Animals ; Cells, Cultured ; Dermis/cytology ; Dermis/drug effects ; Female ; Fibroblasts/drug effects ; Fibroblasts/physiology ; Hemostasis/drug effects ; Humans ; Hydrogels/chemistry ; Hydrogels/pharmacology ; Injections ; Male ; Materials Testing ; Mice ; Mice, Inbred C57BL ; Molecular Structure ; Polymerization ; Polymers/administration & dosage ; Polymers/chemical synthesis ; Polymers/chemistry ; Polymers/pharmacology ; Rats ; Rats, Sprague-Dawley ; Stress, Mechanical ; Tissue Engineering/methods
Czasopismo naukowe
Tytuł:
Novel amino acid Schiff base Zn(II) complexes as new therapeutic approaches in diabetes and Alzheimer's disease: Synthesis, characterization, biological evaluation, and molecular docking studies.
Autorzy:
Şenocak A; Chemistry Department, Art and Science Faculty, Tokat Gaziosmanpasa University, Tokat, Turkey.
Taş NA; Chemistry Department, Art and Science Faculty, Tokat Gaziosmanpasa University, Tokat, Turkey.; Department of Biotechnology, Faculty of Science, Bartin University, Bartin, Turkey.
Taslimi P; Department of Biotechnology, Faculty of Science, Bartin University, Bartin, Turkey.
Tüzün B; Chemistry Department, Science Faculty, Sivas Cumhuriyet University, Sivas, Turkey.
Aydin A; Department of Basic Medical Science, Yozgat Bozok University, Yozgat, Turkey.
Karadağ A; Department of Chemistry, Faculty of Arts and Sciences, Yozgat Bozok University, Yozgat, Turkey.
Pokaż więcej
Źródło:
Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2022 Mar; Vol. 36 (3), pp. e22969. Date of Electronic Publication: 2021 Nov 23.
Typ publikacji:
Journal Article
MeSH Terms:
Acetylcholinesterase*/chemistry
Cholinesterase Inhibitors*/chemical synthesis
Cholinesterase Inhibitors*/chemistry
Cholinesterase Inhibitors*/therapeutic use
Coordination Complexes*/chemical synthesis
Coordination Complexes*/chemistry
Coordination Complexes*/therapeutic use
Molecular Docking Simulation*
Zinc*/chemistry
Zinc*/therapeutic use
Alzheimer Disease/*drug therapy
Butyrylcholinesterase/*chemistry
GPI-Linked Proteins/antagonists & inhibitors ; GPI-Linked Proteins/chemistry ; Humans ; Schiff Bases/chemical synthesis ; Schiff Bases/chemistry ; Schiff Bases/therapeutic use
Czasopismo naukowe
Tytuł:
Novel Selective Galectin-3 Antagonists Are Cytotoxic to Acute Lymphoblastic Leukemia.
Autorzy:
Bum-Erdene K; Institute for Glycomics, Griffith University, Gold Coast Campus, Queensland 4222, Australia.
Collins PM; Institute for Glycomics, Griffith University, Gold Coast Campus, Queensland 4222, Australia.
Hugo MW; Institute for Glycomics, Griffith University, Gold Coast Campus, Queensland 4222, Australia.
Tarighat SS; Section of Molecular Carcinogenesis, Division of Hematology/Oncology and Bone Marrow Transplant, The Saban Research Institute of Children's Hospital Los Angeles, Los Angeles, California 90027, United States.
Fei F; Section of Molecular Carcinogenesis, Division of Hematology/Oncology and Bone Marrow Transplant, The Saban Research Institute of Children's Hospital Los Angeles, Los Angeles, California 90027, United States.
Kishor C; Institute for Glycomics, Griffith University, Gold Coast Campus, Queensland 4222, Australia.
Leffler H; Department of Laboratory Medicine, Section MIG, Lund University, BMC-C1228b, Klinikgatan 28, 221 84 Lund, Sweden.
Nilsson UJ; Centre for Analysis and Synthesis, Department of Chemistry, Lund University, P.O. Box 124, 221 00 Lund, Sweden.
Groffen J; Section of Molecular Carcinogenesis, Division of Hematology/Oncology and Bone Marrow Transplant, The Saban Research Institute of Children's Hospital Los Angeles, Los Angeles, California 90027, United States.
Grice ID; Institute for Glycomics, Griffith University, Gold Coast Campus, Queensland 4222, Australia.; School of Pharmacy and Medical Sciences, Griffith University, Gold Coast Campus, Queensland 4222, Australia.
Heisterkamp N; Section of Molecular Carcinogenesis, Division of Hematology/Oncology and Bone Marrow Transplant, The Saban Research Institute of Children's Hospital Los Angeles, Los Angeles, California 90027, United States.
Blanchard H; Institute for Glycomics, Griffith University, Gold Coast Campus, Queensland 4222, Australia.
Pokaż więcej
Źródło:
Journal of medicinal chemistry [J Med Chem] 2022 Apr 28; Vol. 65 (8), pp. 5975-5989. Date of Electronic Publication: 2022 Apr 15.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/chemical synthesis
Antineoplastic Agents*/chemistry
Antineoplastic Agents*/pharmacology
Precursor Cell Lymphoblastic Leukemia-Lymphoma*/drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma*/metabolism
Binding Sites ; Drug Design ; Galectin 3/antagonists & inhibitors ; Galectin 3/metabolism ; Humans ; Polysaccharides/chemical synthesis ; Polysaccharides/chemistry ; Polysaccharides/pharmacology
Czasopismo naukowe
Tytuł:
Structural variation in the linkage region of pharmaceutical heparin arising from oxidative treatments during manufacture.
Autorzy:
Urso E; Istituto di Ricerche Chimiche e Biochimiche G. Ronzoni, via G. Colombo 81, 20133, Milan, Italy. Electronic address: .
Mantione G; Istituto di Ricerche Chimiche e Biochimiche G. Ronzoni, via G. Colombo 81, 20133, Milan, Italy.
Sala F; Istituto di Ricerche Chimiche e Biochimiche G. Ronzoni, via G. Colombo 81, 20133, Milan, Italy.
Yates EA; Department of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Guerrini M; Istituto di Ricerche Chimiche e Biochimiche G. Ronzoni, via G. Colombo 81, 20133, Milan, Italy.
Naggi A; Istituto di Ricerche Chimiche e Biochimiche G. Ronzoni, via G. Colombo 81, 20133, Milan, Italy.
Pokaż więcej
Źródło:
Carbohydrate research [Carbohydr Res] 2022 Apr; Vol. 514, pp. 108540. Date of Electronic Publication: 2022 Mar 05.
Typ publikacji:
Journal Article
MeSH Terms:
Heparin*/chemical synthesis
Heparin*/chemistry
Oligosaccharides*/chemistry
Animals ; Carbohydrate Sequence ; Heparin Lyase ; Oxidative Stress ; Pharmaceutical Preparations/chemical synthesis ; Swine
Czasopismo naukowe
Tytuł:
Gallium Metal-Organic Nanoparticles with Albumin-Stabilized and Loaded Graphene for Enhanced Delivery to HCT116 Cells.
Autorzy:
Wu YY; School of Chemical Science and Technology, Yunnan University, Kunming, People's Republic of China.
Liao WH; School of Chemical Science and Technology, Yunnan University, Kunming, People's Republic of China.
Niu ZL; School of Chemical Science and Technology, Yunnan University, Kunming, People's Republic of China.
Zhou SH; School of Chemical Science and Technology, Yunnan University, Kunming, People's Republic of China.
Wu TT; School of Chemical Science and Technology, Yunnan University, Kunming, People's Republic of China.
Li Z; Department of Chemical Biology and Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin, People's Republic of China.
Zhao QH; School of Chemical Science and Technology, Yunnan University, Kunming, People's Republic of China.
Xu JY; Department of Chemical Biology and Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics), School of Pharmacy, Tianjin Medical University, Tianjin, People's Republic of China.
Xie MJ; School of Chemical Science and Technology, Yunnan University, Kunming, People's Republic of China.
Pokaż więcej
Źródło:
International journal of nanomedicine [Int J Nanomedicine] 2023 Jan 13; Vol. 18, pp. 225-241. Date of Electronic Publication: 2023 Jan 13 (Print Publication: 2023).
Typ publikacji:
Journal Article
MeSH Terms:
Drug Carriers*/chemical synthesis
Gallium*/chemistry
Graphite*/chemistry
Metal Nanoparticles*/analysis
Oxyquinoline*/chemistry
Antineoplastic Agents*/chemical synthesis
Antineoplastic Agents*/chemistry
Animals ; Humans ; Mice ; Biocompatible Materials ; Cell Line, Tumor ; HCT116 Cells ; Nanoparticles/analysis ; Particle Size ; Serum Albumin, Bovine/pharmacology ; Water
Czasopismo naukowe
Tytuł:
Identification of novel aza-analogs of TN-16 as disrupters of microtubule dynamics through a multicomponent reaction.
Autorzy:
Foroutan A; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', 28100, Novara, Italy.
Corazzari M; Department of Health Science (DSS), Center for Translational Research on Autoimmune and Allergic Disease (CAAD) & Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), Università del Piemonte Orientale 'Amedeo Avogadro,', 28100, Novara, Italy.
Grolla AA; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', 28100, Novara, Italy.
Colombo G; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', 28100, Novara, Italy.
Travelli C; Department of Drug Sciences, Università degli Studi di Pavia, 27100, Pavia, Italy.
Genazzani AA; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', 28100, Novara, Italy.
Theeramunkong S; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Thammasat University Research Unit in Drug, Health Product Development and Application (DHP-DA), Thammasat University, Klong Luang, 12120, Pathum Thani, Thailand.
Galli U; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', 28100, Novara, Italy. Electronic address: .
Tron GC; Department of Pharmaceutical Sciences, Università del Piemonte Orientale 'Amedeo Avogadro', 28100, Novara, Italy.
Pokaż więcej
Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2023 Jan 05; Vol. 245 (Pt 1), pp. 114895. Date of Electronic Publication: 2022 Nov 03.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/chemical synthesis
Antineoplastic Agents*/chemistry
Antineoplastic Agents*/pharmacology
Tubulin Modulators*/chemical synthesis
Tubulin Modulators*/chemistry
Tubulin Modulators*/pharmacology
Pyrrolidinones*/chemical synthesis
Pyrrolidinones*/chemistry
Pyrrolidinones*/pharmacology
Child ; Humans ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Drug Screening Assays, Antitumor ; Microtubules/drug effects ; Structure-Activity Relationship ; Tubulin/metabolism
Czasopismo naukowe
Tytuł:
Novel 4-aminoquinolines: Synthesis, inhibition of the Mycobacterium tuberculosis enoyl-acyl carrier protein reductase, antitubercular activity, SAR, and preclinical evaluation.
Autorzy:
Paz JD; Instituto Nacional de Ciência e Tecnologia em Tuberculose, Centro de Pesquisas em Biologia Molecular e Funcional, Pontifícia Universidade Católica do Rio Grande do Sul, 90616-900, Porto Alegre, Rio Grande do Sul, Brazil; Programa de Pós-Graduação em Biologia Celular e Molecular, Pontifícia Universidade Católica do Rio Grande do Sul, 90616-900, Porto Alegre, Rio Grande do Sul, Brazil.
Denise de Moura Sperotto N; Instituto Nacional de Ciência e Tecnologia em Tuberculose, Centro de Pesquisas em Biologia Molecular e Funcional, Pontifícia Universidade Católica do Rio Grande do Sul, 90616-900, Porto Alegre, Rio Grande do Sul, Brazil.
Ramos AS; Instituto Nacional de Ciência e Tecnologia em Tuberculose, Centro de Pesquisas em Biologia Molecular e Funcional, Pontifícia Universidade Católica do Rio Grande do Sul, 90616-900, Porto Alegre, Rio Grande do Sul, Brazil.
Pissinate K; Instituto Nacional de Ciência e Tecnologia em Tuberculose, Centro de Pesquisas em Biologia Molecular e Funcional, Pontifícia Universidade Católica do Rio Grande do Sul, 90616-900, Porto Alegre, Rio Grande do Sul, Brazil.
da Silva Rodrigues Junior V; Instituto Nacional de Ciência e Tecnologia em Tuberculose, Centro de Pesquisas em Biologia Molecular e Funcional, Pontifícia Universidade Católica do Rio Grande do Sul, 90616-900, Porto Alegre, Rio Grande do Sul, Brazil.
Abbadi BL; Instituto Nacional de Ciência e Tecnologia em Tuberculose, Centro de Pesquisas em Biologia Molecular e Funcional, Pontifícia Universidade Católica do Rio Grande do Sul, 90616-900, Porto Alegre, Rio Grande do Sul, Brazil.
Borsoi AF; Instituto Nacional de Ciência e Tecnologia em Tuberculose, Centro de Pesquisas em Biologia Molecular e Funcional, Pontifícia Universidade Católica do Rio Grande do Sul, 90616-900, Porto Alegre, Rio Grande do Sul, Brazil; Programa de Pós-Graduação em Medicina e Ciências da Saúde, Pontifícia Universidade Católica do Rio Grande do Sul, 90616-900, Porto Alegre, Rio Grande do Sul, Brazil.
Rambo RS; Instituto Nacional de Ciência e Tecnologia em Tuberculose, Centro de Pesquisas em Biologia Molecular e Funcional, Pontifícia Universidade Católica do Rio Grande do Sul, 90616-900, Porto Alegre, Rio Grande do Sul, Brazil.
Corso Minotto AC; Instituto Nacional de Ciência e Tecnologia em Tuberculose, Centro de Pesquisas em Biologia Molecular e Funcional, Pontifícia Universidade Católica do Rio Grande do Sul, 90616-900, Porto Alegre, Rio Grande do Sul, Brazil.
da Silva Dadda A; Instituto Nacional de Ciência e Tecnologia em Tuberculose, Centro de Pesquisas em Biologia Molecular e Funcional, Pontifícia Universidade Católica do Rio Grande do Sul, 90616-900, Porto Alegre, Rio Grande do Sul, Brazil.
Galina L; Instituto Nacional de Ciência e Tecnologia em Tuberculose, Centro de Pesquisas em Biologia Molecular e Funcional, Pontifícia Universidade Católica do Rio Grande do Sul, 90616-900, Porto Alegre, Rio Grande do Sul, Brazil; Programa de Pós-Graduação em Biologia Celular e Molecular, Pontifícia Universidade Católica do Rio Grande do Sul, 90616-900, Porto Alegre, Rio Grande do Sul, Brazil.
Macchi Hopf FS; Instituto Nacional de Ciência e Tecnologia em Tuberculose, Centro de Pesquisas em Biologia Molecular e Funcional, Pontifícia Universidade Católica do Rio Grande do Sul, 90616-900, Porto Alegre, Rio Grande do Sul, Brazil; Programa de Pós-Graduação em Biologia Celular e Molecular, Pontifícia Universidade Católica do Rio Grande do Sul, 90616-900, Porto Alegre, Rio Grande do Sul, Brazil.
Muniz MN; Instituto Nacional de Ciência e Tecnologia em Tuberculose, Centro de Pesquisas em Biologia Molecular e Funcional, Pontifícia Universidade Católica do Rio Grande do Sul, 90616-900, Porto Alegre, Rio Grande do Sul, Brazil.
Borges Martinelli LK; Instituto Nacional de Ciência e Tecnologia em Tuberculose, Centro de Pesquisas em Biologia Molecular e Funcional, Pontifícia Universidade Católica do Rio Grande do Sul, 90616-900, Porto Alegre, Rio Grande do Sul, Brazil.
Roth CD; Instituto Nacional de Ciência e Tecnologia em Tuberculose, Centro de Pesquisas em Biologia Molecular e Funcional, Pontifícia Universidade Católica do Rio Grande do Sul, 90616-900, Porto Alegre, Rio Grande do Sul, Brazil.
Madeira Silva RB; Instituto Nacional de Ciência e Tecnologia em Tuberculose, Centro de Pesquisas em Biologia Molecular e Funcional, Pontifícia Universidade Católica do Rio Grande do Sul, 90616-900, Porto Alegre, Rio Grande do Sul, Brazil.
Perelló MA; Instituto Nacional de Ciência e Tecnologia em Tuberculose, Centro de Pesquisas em Biologia Molecular e Funcional, Pontifícia Universidade Católica do Rio Grande do Sul, 90616-900, Porto Alegre, Rio Grande do Sul, Brazil.
de Matos Czeczot A; Instituto Nacional de Ciência e Tecnologia em Tuberculose, Centro de Pesquisas em Biologia Molecular e Funcional, Pontifícia Universidade Católica do Rio Grande do Sul, 90616-900, Porto Alegre, Rio Grande do Sul, Brazil; Programa de Pós-Graduação em Biologia Celular e Molecular, Pontifícia Universidade Católica do Rio Grande do Sul, 90616-900, Porto Alegre, Rio Grande do Sul, Brazil.
Neves CE; Instituto Nacional de Ciência e Tecnologia em Tuberculose, Centro de Pesquisas em Biologia Molecular e Funcional, Pontifícia Universidade Católica do Rio Grande do Sul, 90616-900, Porto Alegre, Rio Grande do Sul, Brazil; Programa de Pós-Graduação em Biologia Celular e Molecular, Pontifícia Universidade Católica do Rio Grande do Sul, 90616-900, Porto Alegre, Rio Grande do Sul, Brazil.
Duarte LS; Instituto Nacional de Ciência e Tecnologia em Tuberculose, Centro de Pesquisas em Biologia Molecular e Funcional, Pontifícia Universidade Católica do Rio Grande do Sul, 90616-900, Porto Alegre, Rio Grande do Sul, Brazil.
Leyser M; Laboratório de Imunologia e Microbiologia, Pontifícia Universidade Católica do Rio Grande do Sul, 90616-900, Porto Alegre, Rio Grande do Sul, Brazil.
Dias de Oliveira S; Programa de Pós-Graduação em Biologia Celular e Molecular, Pontifícia Universidade Católica do Rio Grande do Sul, 90616-900, Porto Alegre, Rio Grande do Sul, Brazil; Laboratório de Imunologia e Microbiologia, Pontifícia Universidade Católica do Rio Grande do Sul, 90616-900, Porto Alegre, Rio Grande do Sul, Brazil.
Bizarro CV; Instituto Nacional de Ciência e Tecnologia em Tuberculose, Centro de Pesquisas em Biologia Molecular e Funcional, Pontifícia Universidade Católica do Rio Grande do Sul, 90616-900, Porto Alegre, Rio Grande do Sul, Brazil; Programa de Pós-Graduação em Biologia Celular e Molecular, Pontifícia Universidade Católica do Rio Grande do Sul, 90616-900, Porto Alegre, Rio Grande do Sul, Brazil.
Machado P; Instituto Nacional de Ciência e Tecnologia em Tuberculose, Centro de Pesquisas em Biologia Molecular e Funcional, Pontifícia Universidade Católica do Rio Grande do Sul, 90616-900, Porto Alegre, Rio Grande do Sul, Brazil; Programa de Pós-Graduação em Biologia Celular e Molecular, Pontifícia Universidade Católica do Rio Grande do Sul, 90616-900, Porto Alegre, Rio Grande do Sul, Brazil; Programa de Pós-Graduação em Medicina e Ciências da Saúde, Pontifícia Universidade Católica do Rio Grande do Sul, 90616-900, Porto Alegre, Rio Grande do Sul, Brazil. Electronic address: .
Basso LA; Instituto Nacional de Ciência e Tecnologia em Tuberculose, Centro de Pesquisas em Biologia Molecular e Funcional, Pontifícia Universidade Católica do Rio Grande do Sul, 90616-900, Porto Alegre, Rio Grande do Sul, Brazil; Programa de Pós-Graduação em Biologia Celular e Molecular, Pontifícia Universidade Católica do Rio Grande do Sul, 90616-900, Porto Alegre, Rio Grande do Sul, Brazil; Programa de Pós-Graduação em Medicina e Ciências da Saúde, Pontifícia Universidade Católica do Rio Grande do Sul, 90616-900, Porto Alegre, Rio Grande do Sul, Brazil. Electronic address: .
Pokaż więcej
Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2023 Jan 05; Vol. 245 (Pt 1), pp. 114908. Date of Electronic Publication: 2022 Nov 18.
Typ publikacji:
Journal Article
MeSH Terms:
Aminoquinolines*/chemical synthesis
Aminoquinolines*/pharmacology
Aminoquinolines*/therapeutic use
Antitubercular Agents*/chemical synthesis
Antitubercular Agents*/pharmacology
Antitubercular Agents*/therapeutic use
Mycobacterium tuberculosis*/drug effects
Mycobacterium tuberculosis*/enzymology
NAD (+) and NADP (+) Dependent Alcohol Oxidoreductases*/antagonists & inhibitors
Enzyme Inhibitors*/chemical synthesis
Enzyme Inhibitors*/pharmacology
Enzyme Inhibitors*/therapeutic use
Animals ; Mice ; Tuberculosis/drug therapy ; Disease Models, Animal
Czasopismo naukowe
Tytuł:
New drug approvals for 2021: Synthesis and clinical applications.
Autorzy:
Yuan S; Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, 450018, China; School of Pharmaceutical Sciences & Key Laboratory of Advanced Drug Preparation Technologies, Zhengzhou University, Zhengzhou, 450001, China; Department of Pharmacology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, 450001, China. Electronic address: .
Wang DS; Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, 450018, China.
Liu H; School of Pharmaceutical Sciences & Key Laboratory of Advanced Drug Preparation Technologies, Zhengzhou University, Zhengzhou, 450001, China; Department of Pharmacology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, 450001, China.
Zhang SN; Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, 450018, China.
Yang WG; Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, 450018, China.
Lv M; Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, 450018, China.
Zhou YX; Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, 450018, China.
Zhang SY; School of Pharmaceutical Sciences & Key Laboratory of Advanced Drug Preparation Technologies, Zhengzhou University, Zhengzhou, 450001, China; Department of Pharmacology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, 450001, China.
Song J; School of Pharmaceutical Sciences & Key Laboratory of Advanced Drug Preparation Technologies, Zhengzhou University, Zhengzhou, 450001, China; Department of Pharmacology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, 450001, China. Electronic address: .
Liu HM; School of Pharmaceutical Sciences & Key Laboratory of Advanced Drug Preparation Technologies, Zhengzhou University, Zhengzhou, 450001, China; Department of Pharmacology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, 450001, China. Electronic address: .
Pokaż więcej
Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2023 Jan 05; Vol. 245 (Pt 1), pp. 114898. Date of Electronic Publication: 2022 Nov 04.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Biological Products*/pharmacology
Biological Products*/therapeutic use
Biological Products*/chemistry
Drug Approval*
Pharmaceutical Preparations*/chemical synthesis
Pharmaceutical Preparations*/chemistry
Drug Discovery ; United States ; United States Food and Drug Administration ; Humans
Czasopismo naukowe
Tytuł:
Design, synthesis, and biological evaluation of novel quinoline derivatives as small molecule mutant EGFR inhibitors targeting resistance in NSCLC: In vitro screening and ADME predictions.
Autorzy:
Kardile RA; Department of Chemistry, Radhabai Kale Mahila Mahavidyalaya, Ahmednagar, 414001, Maharashtra, India.
Sarkate AP; Department of Chemical Technology, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, 431004, Maharashtra, India.
Lokwani DK; Rajarshi Shahu College of Pharmacy, Buldhana, 443001, Maharashtra, India.
Tiwari SV; Shri Ramkrishna Paramhans College of Pharmacy, Hasnapur, Parbhani, 431401, Maharashtra, India.
Azad R; Department of Animal Biology, University of Hyderabad, Hyderabad, 500046, India.
Thopate SR; Department of Chemistry, Radhabai Kale Mahila Mahavidyalaya, Ahmednagar, 414001, Maharashtra, India. Electronic address: .
Pokaż więcej
Źródło:
European journal of medicinal chemistry [Eur J Med Chem] 2023 Jan 05; Vol. 245 (Pt 1), pp. 114889. Date of Electronic Publication: 2022 Oct 29.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/chemical synthesis
Antineoplastic Agents*/chemistry
Antineoplastic Agents*/pharmacology
Carcinoma, Non-Small-Cell Lung*/drug therapy
ErbB Receptors*/antagonists & inhibitors
Lung Neoplasms*/drug therapy
Lung Neoplasms*/metabolism
Quinolines*/chemical synthesis
Quinolines*/chemistry
Quinolines*/pharmacology
Drug Design*
Humans ; Cell Line, Tumor ; Cell Proliferation ; Drug Screening Assays, Antitumor ; Molecular Docking Simulation ; Protein Kinase Inhibitors/chemistry
Czasopismo naukowe
Tytuł:
Towards Alzheimer's disease-related targets: One-pot Cu(I)- mediated synthesis of new nitroindazolyltriazoles.
Autorzy:
Eddahmi M; Molecular Chemistry, Materials and Catalysis Laboratory, Faculty of Sciences and Technologies, Sultan Moulay Slimane University, BP 523, 23000 Beni-Mellal, Morocco.
La Spada G; Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, via E. Orabona, 4, 70125 Bari, Italy.
Hafid A; Molecular Chemistry, Materials and Catalysis Laboratory, Faculty of Sciences and Technologies, Sultan Moulay Slimane University, BP 523, 23000 Beni-Mellal, Morocco.
Khouili M; Molecular Chemistry, Materials and Catalysis Laboratory, Faculty of Sciences and Technologies, Sultan Moulay Slimane University, BP 523, 23000 Beni-Mellal, Morocco.
Catto M; Department of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, via E. Orabona, 4, 70125 Bari, Italy. Electronic address: .
Bouissane L; Molecular Chemistry, Materials and Catalysis Laboratory, Faculty of Sciences and Technologies, Sultan Moulay Slimane University, BP 523, 23000 Beni-Mellal, Morocco. Electronic address: .
Pokaż więcej
Źródło:
Bioorganic chemistry [Bioorg Chem] 2023 Jan; Vol. 130, pp. 106261. Date of Electronic Publication: 2022 Nov 09.
Typ publikacji:
Journal Article
MeSH Terms:
Alzheimer Disease*/drug therapy
Indazoles*/chemical synthesis
Triazoles*/chemical synthesis
Amyloidogenic Proteins ; Brain ; Cholinesterases ; Monoamine Oxidase ; Copper/chemistry ; Catalysis
Czasopismo naukowe
Tytuł:
Membrane-Targeting Neolignan-Antimicrobial Peptide Mimic Conjugates to Combat Methicillin-Resistant Staphylococcus aureus (MRSA) Infections.
Autorzy:
Yang R; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, Henan, China.
Hou E; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, Henan, China.
Cheng W; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, Henan, China.
Yan X; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, Henan, China.
Zhang T; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, Henan, China.
Li S; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, Henan, China.
Yao H; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, Henan, China.
Liu J; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, Henan, China.
Guo Y; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, Henan, China.
Pokaż więcej
Źródło:
Journal of medicinal chemistry [J Med Chem] 2022 Dec 22; Vol. 65 (24), pp. 16879-16892. Date of Electronic Publication: 2022 Dec 13.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Anti-Bacterial Agents*/chemical synthesis
Anti-Bacterial Agents*/pharmacology
Anti-Bacterial Agents*/therapeutic use
Antimicrobial Peptides*/chemical synthesis
Antimicrobial Peptides*/pharmacology
Antimicrobial Peptides*/therapeutic use
Lignans*/chemical synthesis
Lignans*/pharmacology
Lignans*/therapeutic use
Methicillin-Resistant Staphylococcus aureus*/drug effects
Biofilms/drug effects ; Microbial Sensitivity Tests ; Staphylococcal Infections/drug therapy ; Vancomycin/pharmacology ; Animals ; Mice
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies

Prześlij opinię

Twoje opinie są dla nas bardzo ważne i mogą być niezwykle pomocne w pokazaniu nam, gdzie możemy dokonać ulepszeń. Bylibyśmy bardzo wdzięczni za poświęcenie kilku chwil na wypełnienie krótkiego formularza.

Formularz