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Wyszukujesz frazę ""CHEMICAL synthesis"" wg kryterium: Temat


Tytuł :
[Synthetic biology for the synthesis of mogroside V - a review].
Autorzy :
Sun Z; School of Life Sciences, Beijing Institute of Technology, Beijing 100081, China.
Lü B; School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, China.
Feng Y; School of Life Sciences, Beijing Institute of Technology, Beijing 100081, China.
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Źródło :
Sheng wu gong cheng xue bao = Chinese journal of biotechnology [Sheng Wu Gong Cheng Xue Bao] 2020 Oct 25; Vol. 36 (10), pp. 2017-2028.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Synthetic Biology*
Triterpenes*/chemical synthesis
Biological Products/chemistry ; Sweetening Agents/chemical synthesis
Czasopismo naukowe
Tytuł :
Synthesis of a biodegradable branched copolymer mPEG-b-PLGA-g-OCol and its pH-sensitive micelle.
Autorzy :
Li Y; School of Materials Science and Engineering, Changchun University of Science and Technology, Changchun 130022, China.
Zhang X; School of Materials Science and Engineering, Changchun University of Science and Technology, Changchun 130022, China; Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
Zhang J; School of Materials Science and Engineering, Changchun University of Science and Technology, Changchun 130022, China; Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
Ma J; School of Materials Science and Engineering, Changchun University of Science and Technology, Changchun 130022, China; Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
Chi L; School of Materials Science and Engineering, Changchun University of Science and Technology, Changchun 130022, China.
Qiu N; School of Materials Science and Engineering, Changchun University of Science and Technology, Changchun 130022, China.
Li Y; School of Materials Science and Engineering, Changchun University of Science and Technology, Changchun 130022, China. Electronic address: .
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Źródło :
Materials science & engineering. C, Materials for biological applications [Mater Sci Eng C Mater Biol Appl] 2020 Mar; Vol. 108, pp. 110455. Date of Electronic Publication: 2019 Nov 18.
Typ publikacji :
Journal Article
MeSH Terms :
Biodegradable Plastics*/chemical synthesis
Biodegradable Plastics*/chemistry
Biodegradable Plastics*/pharmacokinetics
Biodegradable Plastics*/pharmacology
Drug Carriers*/chemical synthesis
Drug Carriers*/chemistry
Drug Carriers*/pharmacokinetics
Drug Carriers*/pharmacology
Micelles*
Delayed-Action Preparations/chemical synthesis ; Delayed-Action Preparations/chemistry ; Delayed-Action Preparations/pharmacokinetics ; Delayed-Action Preparations/pharmacology ; Doxorubicin/chemistry ; Doxorubicin/pharmacokinetics ; Doxorubicin/pharmacology ; HeLa Cells ; Humans ; Hydrogen-Ion Concentration ; Polyesters/chemical synthesis ; Polyesters/chemistry ; Polyesters/pharmacokinetics ; Polyesters/pharmacology ; Polyethylene Glycols/chemical synthesis ; Polyethylene Glycols/chemistry ; Polyethylene Glycols/pharmacokinetics ; Polyethylene Glycols/pharmacology
Czasopismo naukowe
Tytuł :
Carbohydrate hitched imidazoles as agents for the disruption of fungal cell membrane.
Autorzy :
Deswal D; Center of Excellence in Pharmaceutical Sciences (CEPS), Guru Gobind Singh Indraprastha University, Delhi 110078, India.
Shukla P; Center of Excellence in Pharmaceutical Sciences (CEPS), Guru Gobind Singh Indraprastha University, Delhi 110078, India.
Azad CS; Center of Excellence in Pharmaceutical Sciences (CEPS), Guru Gobind Singh Indraprastha University, Delhi 110078, India.
Narula AK; Center of Excellence in Pharmaceutical Sciences (CEPS), Guru Gobind Singh Indraprastha University, Delhi 110078, India. Electronic address: .
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Źródło :
Journal de mycologie medicale [J Mycol Med] 2020 Apr; Vol. 30 (1), pp. 100910. Date of Electronic Publication: 2019 Nov 07.
Typ publikacji :
Journal Article
MeSH Terms :
Antifungal Agents*/chemical synthesis
Antifungal Agents*/chemistry
Antifungal Agents*/pharmacology
Carbohydrates/*chemistry
Cell Membrane/*drug effects
Imidazoles/*chemistry
14-alpha Demethylase Inhibitors/chemical synthesis ; 14-alpha Demethylase Inhibitors/chemistry ; 14-alpha Demethylase Inhibitors/pharmacology ; Aspergillus niger/drug effects ; Aspergillus niger/ultrastructure ; Carbohydrate Sequence/physiology ; Cell Membrane Permeability/drug effects ; Humans ; Imidazoles/chemical synthesis ; Imidazoles/pharmacology ; Microbial Sensitivity Tests ; Models, Molecular ; Molecular Docking Simulation ; Molecular Structure ; Sterol 14-Demethylase/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
A bio-responsive 6-mercaptopurine/doxorubicin based "Click Chemistry" polymeric prodrug for cancer therapy.
Autorzy :
Liao J; School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, PR China; School of Materials Science and Engineering, Wuhan University of Technology, Wuhan 430070, PR China.
Peng H; Department of Chemical and Biological Engineering, Iowa State University, Ames, IA 50011, United States; Department of Pharmaceutics, Daqing Campus of Harbin Medical University, Daqing 163319, PR China.
Wei X; School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, PR China.
Song Y; School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, PR China.
Liu C; School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, PR China.
Li D; School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, PR China.
Yin Y; School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, PR China.
Xiong X; School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, PR China.
Zheng H; School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, PR China; School of Materials Science and Engineering, Wuhan University of Technology, Wuhan 430070, PR China. Electronic address: .
Wang Q; Department of Chemical and Biological Engineering, Iowa State University, Ames, IA 50011, United States. Electronic address: .
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Źródło :
Materials science & engineering. C, Materials for biological applications [Mater Sci Eng C Mater Biol Appl] 2020 Mar; Vol. 108, pp. 110461. Date of Electronic Publication: 2019 Nov 19.
Typ publikacji :
Journal Article
MeSH Terms :
Click Chemistry*
Doxorubicin*/chemistry
Doxorubicin*/pharmacology
Drug Carriers*/chemical synthesis
Drug Carriers*/chemistry
Drug Carriers*/pharmacology
Mercaptopurine*/chemistry
Mercaptopurine*/pharmacology
Prodrugs*/chemical synthesis
Prodrugs*/chemistry
Prodrugs*/pharmacology
Neoplasms/*drug therapy
Delayed-Action Preparations/chemical synthesis ; Delayed-Action Preparations/chemistry ; Delayed-Action Preparations/pharmacology ; HL-60 Cells ; HeLa Cells ; Humans ; Neoplasms/metabolism ; Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Smart drug delivery system activated by specific biomolecules.
Autorzy :
Constantin M; Department of Natural Polymers, Bioactive and Biocompatible Materials, 'Petru Poni' Institute of Macromolecular Chemistry, 700487 Iassy, Romania.
Bucatariu S; Department of Natural Polymers, Bioactive and Biocompatible Materials, 'Petru Poni' Institute of Macromolecular Chemistry, 700487 Iassy, Romania.
Ascenzi P; Interdepartmental Laboratory for Electron Microscopy, University Roma Tre, I-00146 Roma, Italy.
Butnaru M; Faculty of Medical Bioengineering, 'Gr. T. Popa' University of Medicine and Pharmacy, 16 University Street, 700115 Iassy, Romania.
Fundueanu G; Department of Natural Polymers, Bioactive and Biocompatible Materials, 'Petru Poni' Institute of Macromolecular Chemistry, 700487 Iassy, Romania. Electronic address: .
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Źródło :
Materials science & engineering. C, Materials for biological applications [Mater Sci Eng C Mater Biol Appl] 2020 Mar; Vol. 108, pp. 110466. Date of Electronic Publication: 2019 Nov 20.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Carriers*/chemical synthesis
Drug Carriers*/chemistry
Drug Carriers*/pharmacokinetics
Drug Carriers*/pharmacology
Materials Testing*
Dermis/*metabolism
Fibroblasts/*metabolism
Animals ; Delayed-Action Preparations/chemical synthesis ; Delayed-Action Preparations/chemistry ; Delayed-Action Preparations/pharmacokinetics ; Delayed-Action Preparations/pharmacology ; Dermis/cytology ; Fibroblasts/cytology ; Hydrogen-Ion Concentration ; Rabbits
Czasopismo naukowe
Tytuł :
Formulary Considerations for Insulins Approved Through the 505(b)(2) "Follow-on" Pathway.
Autorzy :
Rasmussen JT; 1 University of Illinois at Chicago College of Pharmacy, IL, USA.
Ipema HJ; 1 University of Illinois at Chicago College of Pharmacy, IL, USA.
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Źródło :
The Annals of pharmacotherapy [Ann Pharmacother] 2019 Feb; Vol. 53 (2), pp. 204-210. Date of Electronic Publication: 2018 Aug 20.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Drug Approval*/legislation & jurisprudence
Drug Compounding*/methods
Drug Compounding*/standards
Insulins*/chemical synthesis
Insulins*/chemistry
Insulins*/standards
Insulins*/therapeutic use
Biosimilar Pharmaceuticals/*chemical synthesis
Biosimilar Pharmaceuticals/*therapeutic use
Biosimilar Pharmaceuticals/chemistry ; Biosimilar Pharmaceuticals/standards ; Drugs, Generic ; Humans ; Hypoglycemic Agents/therapeutic use ; Insulin/chemical synthesis ; Insulin/chemistry ; Insulin/standards ; Insulin/therapeutic use ; Insulin Glargine/chemical synthesis ; Insulin Glargine/chemistry ; Insulin Glargine/therapeutic use ; United States ; United States Food and Drug Administration/legislation & jurisprudence ; United States Food and Drug Administration/standards
Czasopismo naukowe
Tytuł :
Crystal structure, DNA crosslinking and photo-induced cytotoxicity of oxovanadium(IV) conjugates of boron-dipyrromethene.
Autorzy :
Kumar A; Department of Inorganic and Physical Chemistry, Indian Institute of Science, Sir C.V. Raman Avenue, Bangalore 560012, India.
Dixit A; Department of Biochemistry, Indian Institute of Science, Sir C.V. Raman Avenue, Bangalore 560012, India.
Sahoo S; Department of Inorganic and Physical Chemistry, Indian Institute of Science, Sir C.V. Raman Avenue, Bangalore 560012, India.
Banerjee S; Department of Inorganic and Physical Chemistry, Indian Institute of Science, Sir C.V. Raman Avenue, Bangalore 560012, India.
Bhattacharyya A; Department of Inorganic and Physical Chemistry, Indian Institute of Science, Sir C.V. Raman Avenue, Bangalore 560012, India.
Garai A; Department of Inorganic and Physical Chemistry, Indian Institute of Science, Sir C.V. Raman Avenue, Bangalore 560012, India.
Karande AA; Department of Biochemistry, Indian Institute of Science, Sir C.V. Raman Avenue, Bangalore 560012, India. Electronic address: .
Chakravarty AR; Department of Inorganic and Physical Chemistry, Indian Institute of Science, Sir C.V. Raman Avenue, Bangalore 560012, India. Electronic address: .
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Źródło :
Journal of inorganic biochemistry [J Inorg Biochem] 2020 Jan; Vol. 202, pp. 110817. Date of Electronic Publication: 2019 Sep 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Boron Compounds*/chemical synthesis
Boron Compounds*/chemistry
Boron Compounds*/pharmacology
Cytotoxins*/chemical synthesis
Cytotoxins*/chemistry
Cytotoxins*/pharmacology
DNA*/chemistry
DNA*/metabolism
Photosensitizing Agents*/chemical synthesis
Photosensitizing Agents*/chemistry
Photosensitizing Agents*/pharmacology
Vanadates*/chemistry
Vanadates*/pharmacology
Porphobilinogen/*analogs & derivatives
Boron/chemistry ; Boron/pharmacology ; Crystallography, X-Ray ; HeLa Cells ; Humans ; MCF-7 Cells ; Porphobilinogen/chemical synthesis ; Porphobilinogen/chemistry ; Porphobilinogen/pharmacology
Czasopismo naukowe
Tytuł :
Marcromolecular Architecture and Encapsulation of the Anticancer Drug Everolimus Control the Self-Assembly of Amphiphilic Polypeptide-Containing Hybrids.
Autorzy :
Karatzas A; University of Athens , Department of Chemistry , Panepistimiopolis, Zografou , 15771 , Athens , Greece.
Haataja JS; Aalto University , Department of Applied Physics , FI-00076 , Aalto , Espoo , Finland.
Skoulas D; University of Athens , Department of Chemistry , Panepistimiopolis, Zografou , 15771 , Athens , Greece.
Bilalis P; University of Athens , Department of Chemistry , Panepistimiopolis, Zografou , 15771 , Athens , Greece.
Varlas S; University of Athens , Department of Chemistry , Panepistimiopolis, Zografou , 15771 , Athens , Greece.
Apostolidi P; University of Athens , Department of Chemistry , Panepistimiopolis, Zografou , 15771 , Athens , Greece.
Sofianopoulou S; Hellenic Republic , Ministry of Rural Development and Food , Athens , Greece.
Stratikos E; National Centre for Scientific Research Demokritos , Patriarhou Gregoriou and Neapoleos 27 , Agia Paraskevi 15341 , Athens , Greece.
Houbenov N; Aalto University , Department of Applied Physics , FI-00076 , Aalto , Espoo , Finland.
Ikkala O; Aalto University , Department of Applied Physics , FI-00076 , Aalto , Espoo , Finland.
Iatrou H; University of Athens , Department of Chemistry , Panepistimiopolis, Zografou , 15771 , Athens , Greece.
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Źródło :
Biomacromolecules [Biomacromolecules] 2019 Dec 09; Vol. 20 (12), pp. 4546-4562. Date of Electronic Publication: 2019 Nov 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents*/chemistry
Antineoplastic Agents*/pharmacokinetics
Everolimus*/chemistry
Everolimus*/pharmacokinetics
Hydrogels*/chemical synthesis
Hydrogels*/chemistry
Hydrogels*/pharmacokinetics
Peptides*/chemical synthesis
Peptides*/chemistry
Peptides*/pharmacokinetics
Nanoparticles/*chemistry
Delayed-Action Preparations/chemical synthesis ; Delayed-Action Preparations/chemistry ; Delayed-Action Preparations/pharmacokinetics ; Humans ; Hydrogen-Ion Concentration ; Neoplasms/drug therapy
Czasopismo naukowe
Tytuł :
Synthesis and biological evaluation of new multi-target 3-(1H-indol-3-yl)pyrrolidine-2,5-dione derivatives with potential antidepressant effect.
Autorzy :
Wróbel MZ; Department of Drug Technology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Street, 02-097, Warszawa, Poland. Electronic address: .
Chodkowski A; Department of Drug Technology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Street, 02-097, Warszawa, Poland.
Herold F; Department of Drug Technology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Street, 02-097, Warszawa, Poland.
Marciniak M; Department of Drug Technology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Street, 02-097, Warszawa, Poland.
Dawidowski M; Department of Drug Technology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Street, 02-097, Warszawa, Poland.
Siwek A; Department of Pharmacobiology, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, 30-688, Kraków, Poland.
Starowicz G; Department of Pharmacobiology, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, 30-688, Kraków, Poland.
Stachowicz K; Department of Neurobiology, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31-343, Kraków, Poland.
Szewczyk B; Department of Neurobiology, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31-343, Kraków, Poland.
Nowak G; Department of Pharmacobiology, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Street, 30-688, Kraków, Poland; Department of Neurobiology, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31-343, Kraków, Poland.
Belka M; Department of Pharmaceutical Chemistry, Medical University of Gdańsk, 80-416, Gdańsk, Poland.
Bączek T; Department of Pharmaceutical Chemistry, Medical University of Gdańsk, 80-416, Gdańsk, Poland.
Satała G; Department of Medicinal Chemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31-343, Kraków, Poland.
Bojarski AJ; Department of Medicinal Chemistry, Maj Institute of Pharmacology, Polish Academy of Sciences, 12 Smetna Street, 31-343, Kraków, Poland.
Turło J; Department of Drug Technology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, 1 Banacha Street, 02-097, Warszawa, Poland.
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2019 Dec 01; Vol. 183, pp. 111736. Date of Electronic Publication: 2019 Sep 26.
Typ publikacji :
Journal Article
MeSH Terms :
Antidepressive Agents*/chemical synthesis
Antidepressive Agents*/pharmacology
Indoles*/chemical synthesis
Indoles*/pharmacology
Pyrrolidinones*/chemical synthesis
Pyrrolidinones*/pharmacology
Animals ; CHO Cells ; Cricetulus ; HEK293 Cells ; Humans ; Male ; Mice ; Receptors, Serotonin/metabolism ; Serotonin Uptake Inhibitors/chemical synthesis ; Serotonin Uptake Inhibitors/metabolism ; Serotonin Uptake Inhibitors/pharmacology
Czasopismo naukowe
Tytuł :
Design of DNA-intercalators based copper(II) complexes, investigation of their potential anti-cancer activity and sub-chronic toxicity.
Autorzy :
Bollu VS; Department of Applied Biology, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500007, Telangana State, India.
Bathini T; Inorganic & Physical Chemistry Division, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500007, Telangana State, India.
Barui AK; Department of Applied Biology, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500007, Telangana State, India.
Roy A; Department of Applied Biology, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500007, Telangana State, India.
Ragi NC; National Centre for Mass Spectrometry, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500007, Telangana State, India.
Maloth S; Inorganic & Physical Chemistry Division, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500007, Telangana State, India.
Sripadi P; National Centre for Mass Spectrometry, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500007, Telangana State, India.
Sreedhar B; Inorganic & Physical Chemistry Division, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500007, Telangana State, India. Electronic address: .
Nagababu P; Inorganic & Physical Chemistry Division, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500007, Telangana State, India; Environmental Materials Division, CSIR-National Environmental Engineering Research Institute (NEERI), Nagpur 440020, Maharashtra, India. Electronic address: .
Patra CR; Department of Applied Biology, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad 500007, Telangana State, India. Electronic address: .
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Źródło :
Materials science & engineering. C, Materials for biological applications [Mater Sci Eng C Mater Biol Appl] 2019 Dec; Vol. 105, pp. 110079. Date of Electronic Publication: 2019 Aug 14.
Typ publikacji :
Journal Article
MeSH Terms :
Coordination Complexes*/chemical synthesis
Coordination Complexes*/chemistry
Coordination Complexes*/pharmacology
Copper*/chemistry
Copper*/pharmacology
Intercalating Agents*/chemical synthesis
Intercalating Agents*/chemistry
Intercalating Agents*/pharmacology
Melanoma, Experimental*/drug therapy
Melanoma, Experimental*/metabolism
Melanoma, Experimental*/pathology
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacokinetics ; Cell Line, Tumor ; Chick Embryo ; Humans ; Mice ; Tumor Suppressor Protein p53/metabolism ; bcl-X Protein/metabolism
Czasopismo naukowe
Tytuł :
Development and evaluation of a Tc(V)-nitrido complex derived from estradiol for breast cancer imaging.
Autorzy :
Tejería E; Área de Radioquímica, Facultad de Química, General Flores 2124, Universidad de La República, 11800, Montevideo, Uruguay.
Giglio J; Área de Radioquímica, Facultad de Química, General Flores 2124, Universidad de La República, 11800, Montevideo, Uruguay. Electronic address: .
Fernández L; Área de Radioquímica, Facultad de Química, General Flores 2124, Universidad de La República, 11800, Montevideo, Uruguay.
Rey A; Área de Radioquímica, Facultad de Química, General Flores 2124, Universidad de La República, 11800, Montevideo, Uruguay. Electronic address: .
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Źródło :
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine [Appl Radiat Isot] 2019 Dec; Vol. 154, pp. 108854. Date of Electronic Publication: 2019 Aug 13.
Typ publikacji :
Journal Article
MeSH Terms :
Organotechnetium Compounds*/chemical synthesis
Organotechnetium Compounds*/chemistry
Organotechnetium Compounds*/pharmacokinetics
Radiopharmaceuticals*/chemical synthesis
Radiopharmaceuticals*/chemistry
Radiopharmaceuticals*/pharmacokinetics
Breast Neoplasms/*diagnostic imaging
Animals ; Breast Neoplasms/metabolism ; Drug Stability ; Estradiol/analogs & derivatives ; Estradiol/chemical synthesis ; Estradiol/chemistry ; Female ; Humans ; MCF-7 Cells ; Mice ; Mice, Nude ; Neoplasm Transplantation ; Protein Binding ; Rats ; Rats, Wistar ; Receptors, Estrogen/metabolism ; Tissue Distribution
Czasopismo naukowe
Tytuł :
High in vitro and in vivo antitumor activities of luminecent platinum(II) complexes with jatrorrhizine derivatives.
Autorzy :
Qin QP; Guangxi Key Lab of Agricultural Resources Chemistry and Biotechnology, College of Chemistry and Food Science, Yulin Normal University, 1303 Jiaoyudong Road, Yulin, 537000, PR China; State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, 15 Yucai Road, Guilin, 541004, PR China. Electronic address: .
Zou BQ; State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, 15 Yucai Road, Guilin, 541004, PR China; Department of Chemistry, Guilin Normal College, 9 Feihu Road, Guilin, 541001, China.
Wang ZF; Guangxi Key Lab of Agricultural Resources Chemistry and Biotechnology, College of Chemistry and Food Science, Yulin Normal University, 1303 Jiaoyudong Road, Yulin, 537000, PR China.
Huang XL; Guangxi Key Lab of Agricultural Resources Chemistry and Biotechnology, College of Chemistry and Food Science, Yulin Normal University, 1303 Jiaoyudong Road, Yulin, 537000, PR China.
Zhang Y; Department of Chemistry, Guilin Normal College, 9 Feihu Road, Guilin, 541001, China; School of Pharmacy, Guilin Medical University, Guilin, 541004, China.
Tan MX; Guangxi Key Lab of Agricultural Resources Chemistry and Biotechnology, College of Chemistry and Food Science, Yulin Normal University, 1303 Jiaoyudong Road, Yulin, 537000, PR China; State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, 15 Yucai Road, Guilin, 541004, PR China.
Wang SL; Guangxi Key Lab of Agricultural Resources Chemistry and Biotechnology, College of Chemistry and Food Science, Yulin Normal University, 1303 Jiaoyudong Road, Yulin, 537000, PR China; State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, 15 Yucai Road, Guilin, 541004, PR China.
Liang H; State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, 15 Yucai Road, Guilin, 541004, PR China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2019 Dec 01; Vol. 183, pp. 111727. Date of Electronic Publication: 2019 Sep 21.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents*/chemical synthesis
Antineoplastic Agents*/chemistry
Antineoplastic Agents*/pharmacology
Organoplatinum Compounds*/chemical synthesis
Organoplatinum Compounds*/chemistry
Organoplatinum Compounds*/pharmacology
Berberine/*analogs & derivatives
Platinum/*chemistry
Animals ; Apoptosis/drug effects ; Berberine/chemistry ; Cell Survival/drug effects ; DNA Damage/drug effects ; Fluorescent Dyes/chemical synthesis ; Fluorescent Dyes/chemistry ; HeLa Cells ; Humans ; Male ; Mice, Inbred BALB C ; Mice, Nude ; Mitochondria/drug effects ; Optical Imaging ; Telomerase/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
6-[ I]Iodo-9-pentylpurine for Imaging the Activity of the Sodium Iodide Symporter in the Brain.
Autorzy :
Okamura T; National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology , 4-9-1 Anagawa , Inage-ku, Chiba 263-8555 , Japan.
Tsukamoto S; National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology , 4-9-1 Anagawa , Inage-ku, Chiba 263-8555 , Japan.
Nagatsu K; National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology , 4-9-1 Anagawa , Inage-ku, Chiba 263-8555 , Japan.
Okada M; National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology , 4-9-1 Anagawa , Inage-ku, Chiba 263-8555 , Japan.
Minegishi K; National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology , 4-9-1 Anagawa , Inage-ku, Chiba 263-8555 , Japan.
Tatsumi T; Comprehensive Reproductive Medicine, Regulation of Internal Environment and Reproduction, Graduate School , Tokyo Medical and Dental University , Tokyo 113-8519 , Japan.
Sugyo A; National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology , 4-9-1 Anagawa , Inage-ku, Chiba 263-8555 , Japan.
Kikuchi T; National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology , 4-9-1 Anagawa , Inage-ku, Chiba 263-8555 , Japan.
Wakizaka H; National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology , 4-9-1 Anagawa , Inage-ku, Chiba 263-8555 , Japan.
Ishii H; National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology , 4-9-1 Anagawa , Inage-ku, Chiba 263-8555 , Japan.
Tsuji AB; National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology , 4-9-1 Anagawa , Inage-ku, Chiba 263-8555 , Japan.
Zhang MR; National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology , 4-9-1 Anagawa , Inage-ku, Chiba 263-8555 , Japan.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Feb 27; Vol. 63 (4), pp. 1717-1723. Date of Electronic Publication: 2020 Feb 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Radiopharmaceuticals*/chemical synthesis
Radiopharmaceuticals*/chemistry
Radiopharmaceuticals*/pharmacokinetics
Brain/*diagnostic imaging
Brain/*metabolism
Purines/*pharmacology
Symporters/*metabolism
Animals ; Iodides/metabolism ; Iodine Radioisotopes/chemistry ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Positron-Emission Tomography ; Purines/chemical synthesis ; Purines/chemistry ; Purines/pharmacokinetics ; Symporters/genetics
Czasopismo naukowe
Tytuł :
Synthesis and In Vitro Photocytotoxicity of 9-/13-Lipophilic Substituted Berberine Derivatives as Potential Anticancer Agents.
Autorzy :
Lin HJ; Department of Microbiology, Immunology and Biopharmaceuticals, College of Life Sciences, National Chiayi University, Chiayi 60004, Taiwan.
Ho JH; Department of Chemical Engineering, College of Engineering, National Taiwan University of Science and Technology, Taipei 10607, Taiwan.
Tsai LC; Department of Microbiology, Immunology and Biopharmaceuticals, College of Life Sciences, National Chiayi University, Chiayi 60004, Taiwan.
Yang FY; Department of Microbiology, Immunology and Biopharmaceuticals, College of Life Sciences, National Chiayi University, Chiayi 60004, Taiwan.
Yang LL; Department of Pharmacognosy, School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan.
Kuo CD; Division of Chest Medicine, Department of Internal Medicine, Changhua Christian Hospital, Changhua 50006, Taiwan.; Department of Medical Research, Taipei Veterans General Hospital, Taipei 11217, Taiwan.
Chen LG; Department of Microbiology, Immunology and Biopharmaceuticals, College of Life Sciences, National Chiayi University, Chiayi 60004, Taiwan.
Liu YW; Department of Microbiology, Immunology and Biopharmaceuticals, College of Life Sciences, National Chiayi University, Chiayi 60004, Taiwan.
Wu JY; Department of Microbiology, Immunology and Biopharmaceuticals, College of Life Sciences, National Chiayi University, Chiayi 60004, Taiwan.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Feb 05; Vol. 25 (3). Date of Electronic Publication: 2020 Feb 05.
Typ publikacji :
Journal Article
MeSH Terms :
Berberine*/analogs & derivatives
Berberine*/chemical synthesis
Berberine*/pharmacology
Antineoplastic Agents/*pharmacology
Carcinoma, Hepatocellular/*drug therapy
Liver Neoplasms/*drug therapy
Antineoplastic Agents/chemical synthesis ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; HT29 Cells ; Hep G2 Cells ; Humans ; Membrane Potential, Mitochondrial/drug effects ; Reactive Oxygen Species/metabolism ; S Phase Cell Cycle Checkpoints/drug effects
Czasopismo naukowe
Tytuł :
Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics.
Autorzy :
Ast J; Institute of Metabolism and Systems Research (IMSR), and Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham, UK.; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK.
Arvaniti A; Institute of Metabolism and Systems Research (IMSR), and Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham, UK.; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK.
Fine NHF; Institute of Metabolism and Systems Research (IMSR), and Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham, UK.; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK.
Nasteska D; Institute of Metabolism and Systems Research (IMSR), and Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham, UK.; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK.
Ashford FB; Institute of Metabolism and Systems Research (IMSR), and Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham, UK.; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK.
Stamataki Z; Centre for Liver Research, College of Medical and Dental Sciences, Institute for Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Koszegi Z; Institute of Metabolism and Systems Research (IMSR), and Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham, UK.; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK.
Bacon A; Genome Editing Facility, Technology Hub, University of Birmingham, Birmingham, UK.
Jones BJ; Division of Diabetes, Endocrinology and Metabolism, Section of Investigative Medicine, Imperial College London, London, UK.
Lucey MA; Division of Diabetes, Endocrinology and Metabolism, Section of Investigative Medicine, Imperial College London, London, UK.
Sasaki S; Diabetes Research Group, BC Children's Hospital Research Institute, Vancouver, BC, Canada; Department of Surgery, University of British Columbia, Vancouver, BC, Canada.
Brierley DI; Centre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology & Pharmacology, University College London, London, UK.
Hastoy B; Oxford Centre for Diabetes, Endocrinology & Metabolism, University of Oxford, Oxford, UK.
Tomas A; Division of Diabetes, Endocrinology and Metabolism, Section of Cell Biology and Functional Genomics, Imperial College London, London, UK.
D'Agostino G; Faculty of Biology, Medicine and Health, University of Manchester, Oxford Road, Manchester, UK.
Reimann F; Wellcome Trust-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Lynn FC; Diabetes Research Group, BC Children's Hospital Research Institute, Vancouver, BC, Canada; Department of Surgery, University of British Columbia, Vancouver, BC, Canada.
Reissaus CA; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
Linnemann AK; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
D'Este E; Optical Microscopy Facility, Max Planck Institute for Medical Research, Heidelberg, Germany.
Calebiro D; Institute of Metabolism and Systems Research (IMSR), and Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham, UK.; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK.
Trapp S; Centre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology & Pharmacology, University College London, London, UK.
Johnsson K; Department of Chemical Biology, Max Planck Institute for Medical Research, Heidelberg, Germany.
Podewin T; Department of Chemical Biology, Max Planck Institute for Medical Research, Heidelberg, Germany. .
Broichhagen J; Department of Chemical Biology, Max Planck Institute for Medical Research, Heidelberg, Germany. .
Hodson DJ; Institute of Metabolism and Systems Research (IMSR), and Centre of Membrane Proteins and Receptors (COMPARE), University of Birmingham, Birmingham, UK. .; Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK. .
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Źródło :
Nature communications [Nat Commun] 2020 Jan 24; Vol. 11 (1), pp. 467. Date of Electronic Publication: 2020 Jan 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Fluorescent Dyes*/chemical synthesis
Fluorescent Dyes*/chemistry
Glucagon-Like Peptide-1 Receptor/*metabolism
Microscopy, Fluorescence, Multiphoton/*methods
Amino Acid Sequence ; Animals ; Brain/metabolism ; Cell Line ; Glucagon-Like Peptide-1 Receptor/antagonists & inhibitors ; Glucagon-Like Peptide-1 Receptor/deficiency ; Glucagon-Like Peptide-1 Receptor/genetics ; HEK293 Cells ; Human Embryonic Stem Cells/metabolism ; Humans ; Islets of Langerhans/metabolism ; Mice ; Mice, Knockout ; Models, Molecular ; Molecular Structure ; Peptide Fragments/chemical synthesis ; Peptide Fragments/chemistry ; Peptide Fragments/genetics ; Signal Transduction ; Tissue Distribution
Czasopismo naukowe
Tytuł :
Synthesis of Spin-Labelled Bergamottin: A Potent CYP3A4 Inhibitor with Antiproliferative Activity.
Autorzy :
Zsidó BZ; Department of Pharmacology and Pharmacotherapy, University of Pécs, Medical School, Szigeti út 12, H-7624 Pécs, Hungary.
Balog M; Institute of Organic and Medicinal Chemistry, University of Pécs, Medical School, Honvéd utca 1, H-7624 Pécs, Hungary.
Erős N; Institute of Organic and Medicinal Chemistry, University of Pécs, Medical School, Honvéd utca 1, H-7624 Pécs, Hungary.
Poór M; Department of Pharmacology, University of Pécs, Faculty of Pharmacy, Szigeti út 12, H-7624 Pécs, Hungary.; János Szentágothai Research Center, University of Pécs, Ifjúság útja 20, H-7624 Pécs, Hungary.
Mohos V; Department of Pharmacology, University of Pécs, Faculty of Pharmacy, Szigeti út 12, H-7624 Pécs, Hungary.; János Szentágothai Research Center, University of Pécs, Ifjúság útja 20, H-7624 Pécs, Hungary.
Fliszár-Nyúl E; Department of Pharmacology, University of Pécs, Faculty of Pharmacy, Szigeti út 12, H-7624 Pécs, Hungary.; János Szentágothai Research Center, University of Pécs, Ifjúság útja 20, H-7624 Pécs, Hungary.
Hetényi C; Department of Pharmacology and Pharmacotherapy, University of Pécs, Medical School, Szigeti út 12, H-7624 Pécs, Hungary.
Nagane M; Department of Biochemistry, School of Veterinary Medicine, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan.
Hideg K; Institute of Organic and Medicinal Chemistry, University of Pécs, Medical School, Honvéd utca 1, H-7624 Pécs, Hungary.
Kálai T; Institute of Organic and Medicinal Chemistry, University of Pécs, Medical School, Honvéd utca 1, H-7624 Pécs, Hungary.; János Szentágothai Research Center, University of Pécs, Ifjúság útja 20, H-7624 Pécs, Hungary.
Bognár B; Institute of Organic and Medicinal Chemistry, University of Pécs, Medical School, Honvéd utca 1, H-7624 Pécs, Hungary.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Jan 13; Vol. 21 (2). Date of Electronic Publication: 2020 Jan 13.
Typ publikacji :
Journal Article
MeSH Terms :
Cytochrome P-450 CYP3A Inhibitors*/chemical synthesis
Cytochrome P-450 CYP3A Inhibitors*/chemistry
Cytochrome P-450 CYP3A Inhibitors*/pharmacology
Furocoumarins*/chemistry
Furocoumarins*/pharmacology
Cell Proliferation/*drug effects
Cytochrome P-450 CYP3A/*metabolism
Spin Labels/*chemical synthesis
Animals ; HeLa Cells ; Humans ; Mice ; NIH 3T3 Cells
Czasopismo naukowe
Tytuł :
[Significant target misidentification].
Autorzy :
Jordan B; UMR 7268 ADÉS, Aix-Marseille, Université /EFS/CNRS ; CoReBio PACA, case 901, Parc scientifique de Luminy, 13288 Marseille Cedex 09, France.
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Transliterated Title :
Méprise sur les cibles - Chroniques génomiques.
Źródło :
Medecine sciences : M/S [Med Sci (Paris)] 2020 Jan; Vol. 36 (1), pp. 87-89. Date of Electronic Publication: 2020 Feb 04.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents*/chemical synthesis
Antineoplastic Agents*/isolation & purification
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Drug Development*/standards
Drug Development*/trends
Drug Discovery*/methods
Drug Discovery*/standards
Drug Discovery*/trends
Molecular Targeted Therapy*/methods
Molecular Targeted Therapy*/standards
Scientific Experimental Error*/trends
Animals ; Cell Survival/drug effects ; Humans ; Naphthyridines/chemical synthesis ; Naphthyridines/pharmacology ; Naphthyridines/therapeutic use ; Protein-Serine-Threonine Kinases/antagonists & inhibitors ; Protein-Serine-Threonine Kinases/physiology ; Terminology as Topic ; Validation Studies as Topic
Czasopismo naukowe
Tytuł :
Polyphosphonium-oligochitosans decorated with nanosilver as new prospective inhibitors for common human enteric viruses.
Autorzy :
Sofy AR; Botany and Microbiology Department, Faculty of Science, Al-Azhar University, 11884 Nasr City, Cairo, Egypt. Electronic address: .
Hmed AA; Botany and Microbiology Department, Faculty of Science, Al-Azhar University, 11884 Nasr City, Cairo, Egypt.
Abd El Haliem NF; Microbiology and Immunology Department, Faculty of Medicine (Girls), Al-Azhar University, Nasr City, Cairo, Egypt.
Zein MA; Faculty of Science, Chemistry Department, Damanhour University, Egypt.
Elshaarawy RFM; Institut für Anorganische Chemie und Strukturchemie, Heinrich-Heine Universität Düsseldorf, 40204 Düsseldorf, Germany; Faculty of Science, Suez University, Suez, Egypt. Electronic address: .
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Źródło :
Carbohydrate polymers [Carbohydr Polym] 2019 Dec 15; Vol. 226, pp. 115261. Date of Electronic Publication: 2019 Aug 28.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents*/chemical synthesis
Antiviral Agents*/chemistry
Antiviral Agents*/pharmacology
Chitin/*analogs & derivatives
Enterovirus/*drug effects
Hepatitis A virus/*drug effects
Nanocomposites/*chemistry
Norovirus/*drug effects
Silver/*pharmacology
Chitin/chemical synthesis ; Chitin/chemistry ; Chitin/pharmacology ; Silver/chemistry
Czasopismo naukowe
Tytuł :
Structure based design, synthesis and in vitro antitumour activity of tiazofurin stereoisomers with nitrogen functions at the C-2' or C-3' positions.
Autorzy :
Kojić V; Oncology Institute of Vojvodina, Faculty of Medicine, University of Novi Sad, Put Dr Goldmana 4, 21204, Sremska Kamenica, Serbia.
Popsavin M; Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovića 3, Novi Sad, Serbia. Electronic address: .
Spaić S; Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovića 3, Novi Sad, Serbia.
Jakimov D; Oncology Institute of Vojvodina, Faculty of Medicine, University of Novi Sad, Put Dr Goldmana 4, 21204, Sremska Kamenica, Serbia.
Kovačević I; Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovića 3, Novi Sad, Serbia.
Svirčev M; Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovića 3, Novi Sad, Serbia.
Aleksić L; Oncology Institute of Vojvodina, Faculty of Medicine, University of Novi Sad, Put Dr Goldmana 4, 21204, Sremska Kamenica, Serbia.
Zelenović BS; Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovića 3, Novi Sad, Serbia.
Popsavin V; Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovića 3, Novi Sad, Serbia; Serbian Academy of Sciences and Arts, Knez Mihajlova 35, 11000, Belgrade, Serbia.
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2019 Dec 01; Vol. 183, pp. 111712. Date of Electronic Publication: 2019 Sep 18.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents*/chemical synthesis
Antineoplastic Agents*/chemistry
Antineoplastic Agents*/pharmacology
Drug Design*
Ribavirin/*analogs & derivatives
Cell Survival/drug effects ; Humans ; K562 Cells ; Nitrogen/chemistry ; Ribavirin/chemical synthesis ; Ribavirin/chemistry ; Ribavirin/pharmacology ; Stereoisomerism ; Structure-Activity Relationship
Czasopismo naukowe

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