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Tytuł:
Prebiotically plausible chemoselective pantetheine synthesis in water.
Autorzy:
Fairchild J; Department of Chemistry, University College London, London WC1H 0AJ, UK.
Islam S; Department of Chemistry, University College London, London WC1H 0AJ, UK.; Department of Chemistry and Centre for the Physical Science of Life, King's College London, London SE1 1DB, UK.
Singh J; Department of Chemistry, University College London, London WC1H 0AJ, UK.
Bučar DK; Department of Chemistry, University College London, London WC1H 0AJ, UK.
Powner MW; Department of Chemistry, University College London, London WC1H 0AJ, UK.
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Źródło:
Science (New York, N.Y.) [Science] 2024 Feb 23; Vol. 383 (6685), pp. 911-918. Date of Electronic Publication: 2024 Feb 22.
Typ publikacji:
Journal Article
MeSH Terms:
Coenzyme A*/chemistry
Pantetheine*/chemical synthesis
Origin of Life*
Water/chemistry ; Nitriles/chemistry ; Hydroxybutyrates/chemical synthesis ; 4-Butyrolactone/chemical synthesis ; Amino Acids/chemical synthesis
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Phosphates Induced H-Type or J-Type Aggregation of Cationic Porphyrins with Varied Side Chains.
Autorzy:
Li Z; Department of Chemistry, University of Texas at San Antonio, San Antonio, TX 78249, USA.; Department of Chemistry, University of Florida, Gainesville, FL 32611, USA.
Zeman CJ 4th; Department of Chemistry, University of Texas at San Antonio, San Antonio, TX 78249, USA.; Department of Chemistry, University of Florida, Gainesville, FL 32611, USA.
Valandro S; Department of Chemistry, University of Texas at San Antonio, San Antonio, TX 78249, USA.
Bantang JPO; Department of Chemistry, University of Texas at San Antonio, San Antonio, TX 78249, USA.
Schanze KS; Department of Chemistry, University of Texas at San Antonio, San Antonio, TX 78249, USA.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 May 16; Vol. 28 (10). Date of Electronic Publication: 2023 May 16.
Typ publikacji:
Journal Article
MeSH Terms:
Porphyrins*/chemical synthesis
Diphosphates*/chemistry
Adenosine Triphosphate*/chemistry
Nanostructures*/chemistry
Cations/chemical synthesis ; Alkaline Phosphatase/chemistry ; Molecular Structure ; Molecular Docking Simulation ; Static Electricity ; Water/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
An antibiotic preorganized for ribosomal binding overcomes antimicrobial resistance.
Autorzy:
Wu KJY; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Tresco BIC; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Ramkissoon A; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Aleksandrova EV; Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA.
Syroegin EA; Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA.
See DNY; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Liow P; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Dittemore GA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Yu M; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Testolin G; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Mitcheltree MJ; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Liu RY; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Svetlov MS; Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA.; Center for Biomolecular Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA.
Polikanov YS; Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA.; Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA.; Center for Biomolecular Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA.
Myers AG; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2024 Feb 16; Vol. 383 (6684), pp. 721-726. Date of Electronic Publication: 2024 Feb 15.
Typ publikacji:
Journal Article
MeSH Terms:
Anti-Bacterial Agents*/chemical synthesis
Anti-Bacterial Agents*/chemistry
Anti-Bacterial Agents*/pharmacology
Drug Resistance, Multiple, Bacterial*
Bridged-Ring Compounds*/chemical synthesis
Bridged-Ring Compounds*/chemistry
Bridged-Ring Compounds*/pharmacology
Oxepins*/chemical synthesis
Oxepins*/chemistry
Oxepins*/pharmacology
Lincosamides*/chemical synthesis
Lincosamides*/chemistry
Lincosamides*/pharmacology
Erythromycin/chemistry ; Erythromycin/pharmacology ; Microbial Sensitivity Tests ; Staphylococcus aureus/drug effects ; Escherichia coli/drug effects ; Pseudomonas aeruginosa/drug effects ; Animals ; Mice ; Drug Design ; Ribosomes/chemistry
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Design, synthesis and in-vitro anti-depressant activity evaluation of some 2-styrylbenzimidazole derivatives.
Autorzy:
Sahariah, Manisha (AUTHOR)
Chowdhury, Rubina (AUTHOR)
Pegu, Padmanath (AUTHOR)
Ali, Farak (AUTHOR)
Dutta, Rajat Subhra (AUTHOR)
Sahu, Supriya (AUTHOR)
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Źródło:
Future Journal of Pharmaceutical Sciences. 2/15/2024, Vol. 10 Issue 1, p1-16. 16p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
An oxidative photocyclization approach to the synthesis of Securiflustra securifrons alkaloids.
Autorzy:
Alexander BW; Department of Chemistry, Yale University, New Haven, CT 06511, USA.
Bartfield NM; Department of Chemistry, Yale University, New Haven, CT 06511, USA.
Gupta V; Department of Chemistry, Yale University, New Haven, CT 06511, USA.
Mercado BQ; Department of Chemistry, Yale University, New Haven, CT 06511, USA.; Chemical and Biological Instrumentation Center, Yale University, New Haven, CT 06511, USA.
Del Campo M; Rigaku Americas Corporation, The Woodlands, TX 77381, USA.
Herzon SB; Department of Chemistry, Yale University, New Haven, CT 06511, USA.; Department of Pharmacology, Yale School of Medicine, New Haven, CT 06510, USA.; Department of Therapeutic Radiology, Yale School of Medicine, New Haven, CT 06510, USA.
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Źródło:
Science (New York, N.Y.) [Science] 2024 Feb 23; Vol. 383 (6685), pp. 849-854. Date of Electronic Publication: 2024 Feb 22.
Typ publikacji:
Journal Article
MeSH Terms:
Alkaloids*/chemical synthesis
Bryozoa*
Alkenes/chemistry ; Azides/chemistry ; Electrons ; Animals ; Catalysis ; Oxidation-Reduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Synthesis and Anticancer Evaluation of New Indole-Based Tyrphostin Derivatives and Their ( p -Cymene)dichloridoruthenium(II) Complexes.
Autorzy:
Oberhuber N; Organic Chemistry 1, University of Bayreuth, Universitätsstrasse 30, 95440 Bayreuth, Germany.
Ghosh H; Department of Cancer Biology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA.
Nitzsche B; Institute of Physiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Charitéplatz 1, 10117 Berlin, Germany.
Dandawate P; Department of Cancer Biology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA.
Höpfner M; Institute of Physiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Charitéplatz 1, 10117 Berlin, Germany.
Schobert R; Organic Chemistry 1, University of Bayreuth, Universitätsstrasse 30, 95440 Bayreuth, Germany.
Biersack B; Organic Chemistry 1, University of Bayreuth, Universitätsstrasse 30, 95440 Bayreuth, Germany.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Jan 03; Vol. 24 (1). Date of Electronic Publication: 2023 Jan 03.
Typ publikacji:
Journal Article
MeSH Terms:
Antineoplastic Agents*/chemical synthesis
Antineoplastic Agents*/pharmacology
Protein Kinase Inhibitors*/chemical synthesis
Protein Kinase Inhibitors*/pharmacology
Tyrphostins*/chemical synthesis
Tyrphostins*/pharmacology
Humans ; Cell Proliferation ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Indoles/chemical synthesis ; Indoles/pharmacology ; Molecular Docking Simulation ; Molecular Structure ; Structure-Activity Relationship ; Tumor Suppressor Protein p53 ; Vascular Endothelial Growth Factor Receptor-2/metabolism ; HCT116 Cells
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Synthesis, DFT calculations, and anti-proliferative evaluation of pyrimidine and selenadiazolopyrimidine derivatives as dual Topoisomerase II and HSP90 inhibitors.
Autorzy:
El-Kalyoubi S; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Port Said University, Port Said, Egypt.
El-Sebaey SA; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.
Rashad AM; Accelerator and Ion Sources Department, Nuclear Research Center, Atomic Energy Authority, Cairo, Egypt.; Central Lab for Elemental and Isotopic Analysis, NRC, Atomic Energy Authority, Cairo, Egypt.
Al-Ghulikah HA; Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
Ghorab MM; Department of Drug Radiation Research, National Centre for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt.
Elfeky SM; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2023 Dec; Vol. 38 (1), pp. 2198163.
Typ publikacji:
Journal Article
MeSH Terms:
Pyrimidines*/chemical synthesis
Pyrimidines*/pharmacology
Topoisomerase II Inhibitors*/chemical synthesis
Topoisomerase II Inhibitors*/pharmacology
HSP90 Heat-Shock Proteins*/antagonists & inhibitors
Antineoplastic Agents*/chemical synthesis
Antineoplastic Agents*/pharmacology
Hep G2 Cells ; A549 Cells ; MCF-7 Cells ; Humans ; Cell Proliferation/drug effects ; Gene Expression Regulation/drug effects ; Cell Cycle/drug effects ; Computer Simulation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Benzimidazole-Based Derivatives as Apoptotic Antiproliferative Agents: Design, Synthesis, Docking, and Mechanistic Studies.
Autorzy:
Youssif, Bahaa G. M. (AUTHOR)
Morcoss, Martha M. (AUTHOR)
Bräse, Stefan (AUTHOR)
Abdel-Aziz, Mohamed (AUTHOR)
Abdel-Rahman, Hamdy M. (AUTHOR)
Abou El-Ella, Dalal A. (AUTHOR)
Abdelhafez, El Shimaa M. N. (AUTHOR)
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Źródło:
Molecules. Jan2024, Vol. 29 Issue 2, p446. 28p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Rationally Designed Novel Phenyloxazoline Synthase Inhibitors: Chemical Synthesis and Biological Evaluation to Accelerate the Discovery of New Antimycobacterial Antibiotics.
Autorzy:
Shyam, Mousumi (AUTHOR)
Bhattacharje, Gourab (AUTHOR)
Daniel, Chris (AUTHOR)
Kumar, Amrendra (AUTHOR)
Yadav, Pragya (AUTHOR)
Mukherjee, Piyali (AUTHOR)
Singh, Samsher (AUTHOR)
Das, Amit Kumar (AUTHOR)
Narender, Tadigoppula (AUTHOR)
Singh, Amit (AUTHOR)
Jayaprakash, Venkatesan (AUTHOR)
Bhakta, Sanjib (AUTHOR)
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Źródło:
Molecules. Dec2023, Vol. 28 Issue 24, p8115. 17p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Radiation synthesis and chemical modifications of p(AAm-co-AAc) hydrogel for improving their adsorptive removal of metal ions from polluted water.
Autorzy:
Abdel Maksoud, Israa Kamal (AUTHOR)
Bassioni, Ghada (AUTHOR)
Nady, Norhan (AUTHOR)
Younis, Sherif A. (AUTHOR)
Ghobashy, Mohamed Mohamady (AUTHOR)
Abdel-Mottaleb, M. S. A. (AUTHOR)
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Źródło:
Scientific Reports. 12/11/2023, p1-19. 19p.
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 119170

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