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Tytuł :
CHO cell dysfunction due to radiation-induced bystander signals observed by real-time electrical impedance measurement.
Autorzy :
Ilyas AM; Department of Physics, City University of Hong Kong, Kowloon 999077, Hong Kong, China; Department of Physics, Federal University Oye-Ekiti, Ekiti State 3600001, Nigeria. Electronic address: .
Alam MK; Department of Biomedical Sciences, City University of Hong Kong, Kowloon 999077, Hong Kong, China; Department of Physics, University of Chittagong, Chittagong 4331, Bangladesh.
Musah JD; Department of Material Science and Engineering, State Key Laboratory of Terahertz and Millimeter Waves, City University of Hong Kong, Kowloon 999077, Hong Kong, China.
Yang M; Department of Biomedical Sciences, City University of Hong Kong, Kowloon 999077, Hong Kong, China.
Roy VAL; James Watt School of Engineering, University of Glasgow, Glasgow G12 8QQ, United Kingdom.
Lam YW; Department of Chemistry, City University of Hong Kong, Kowloon 999077, Hong Kong, China.
Lau C; Department of Physics, City University of Hong Kong, Kowloon 999077, Hong Kong, China.
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Źródło :
Biosensors & bioelectronics [Biosens Bioelectron] 2021 Jun 01; Vol. 181, pp. 113142. Date of Electronic Publication: 2021 Mar 05.
Typ publikacji :
Journal Article
MeSH Terms :
Biosensing Techniques*
Animals ; Bystander Effect ; CHO Cells ; Cricetinae ; Cricetulus ; Electric Impedance
Czasopismo naukowe
Tytuł :
The role of protein hydrolysates in prolonging viability and enhancing antibody production of CHO cells.
Autorzy :
Obaidi I; Cell Technology Group, National Institute for Bioprocessing, Research and Training (NIBRT), Fosters Avenue, Mount Merrion, Blackrock, Dublin, A94 X099, Ireland.; College of Pharmacy, University of Babylon, Babylon, Iraq.
Mota LM; Cell Technology Group, National Institute for Bioprocessing, Research and Training (NIBRT), Fosters Avenue, Mount Merrion, Blackrock, Dublin, A94 X099, Ireland.; School of Chemical and Bioprocess Engineering, University College Dublin, Dublin, D04 V1W8, Ireland.
Quigley A; Cell Technology Group, National Institute for Bioprocessing, Research and Training (NIBRT), Fosters Avenue, Mount Merrion, Blackrock, Dublin, A94 X099, Ireland.
Butler M; Cell Technology Group, National Institute for Bioprocessing, Research and Training (NIBRT), Fosters Avenue, Mount Merrion, Blackrock, Dublin, A94 X099, Ireland. .; School of Chemical and Bioprocess Engineering, University College Dublin, Dublin, D04 V1W8, Ireland. .
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Źródło :
Applied microbiology and biotechnology [Appl Microbiol Biotechnol] 2021 Apr; Vol. 105 (8), pp. 3115-3129. Date of Electronic Publication: 2021 Apr 01.
Typ publikacji :
Journal Article
MeSH Terms :
Antibody Formation*
Protein Hydrolysates*
Animals ; CHO Cells ; Cell Culture Techniques ; Cricetinae ; Cricetulus ; Culture Media
Czasopismo naukowe
Tytuł :
Optimization of a transient antibody expression platform towards high titer and efficiency.
Autorzy :
Greene E; Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, USA.
Cazacu D; Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, USA.
Tamot N; Janssen Biotherapeutics, Spring House, Pennsylvania, USA.
Castellano S; Duke University School of Medicine, Durham, North Carolina, USA.
Datar A; Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, USA.
Kronkaitis A; Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, USA.
Gebhard D; Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, USA.
Reed J; Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, USA.
Mawson P; Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, USA.
Florin L; Bristol Myers Squibb, Redwood City, California, USA.
Rossi N; MirusBio LLC, Madison, Wisconsin, USA.
Lauer A; MirusBio LLC, Madison, Wisconsin, USA.
Juckem L; MirusBio LLC, Madison, Wisconsin, USA.
Nixon A; Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, USA.
Wenger T; Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, USA.
Sen S; Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut, USA.
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Źródło :
Biotechnology journal [Biotechnol J] 2021 Apr; Vol. 16 (4), pp. e2000251. Date of Electronic Publication: 2021 Jan 25.
Typ publikacji :
Journal Article
MeSH Terms :
Polyethyleneimine*
Animals ; CHO Cells ; Cricetinae ; Cricetulus ; Recombinant Proteins/genetics ; Transfection
Czasopismo naukowe
Tytuł :
SARS_CoV2 RBD gene transcription cannot be driven by CMV promoter.
Autorzy :
Xie L; Hubei Engineering Research Center of Viral Vector, Applied Biotechnology Research Center, Wuhan University of Bioengineering, Wuhan, 430415, China. Electronic address: .
Yi K; Hubei Engineering Research Center of Viral Vector, Applied Biotechnology Research Center, Wuhan University of Bioengineering, Wuhan, 430415, China. Electronic address: .
Li Y; Hubei Engineering Research Center of Viral Vector, Applied Biotechnology Research Center, Wuhan University of Bioengineering, Wuhan, 430415, China. Electronic address: .
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Źródło :
Virology [Virology] 2021 Jun; Vol. 558, pp. 22-27. Date of Electronic Publication: 2021 Mar 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Promoter Regions, Genetic*
COVID-19/*virology
Cytomegalovirus/*genetics
SARS-CoV-2/*genetics
Spike Glycoprotein, Coronavirus/*genetics
Actins/genetics ; Animals ; CHO Cells ; Chickens ; Chlorocebus aethiops ; Cloning, Molecular ; Cricetulus ; HEK293 Cells ; Humans ; Protein Domains ; Transcription, Genetic ; Vaccinia/genetics ; Vero Cells
Czasopismo naukowe
Tytuł :
Subcloning induces changes in the DNA-methylation pattern of outgrowing Chinese hamster ovary cell colonies.
Autorzy :
Weinguny M; ACIB Gmbh, Austrian Centre of Industrial Biotechnology, Vienna, Austria.; Department of Biotechnology, University of Natural Resources and Life Sciences, Vienna, Vienna, Austria.
Klanert G; ACIB Gmbh, Austrian Centre of Industrial Biotechnology, Vienna, Austria.
Eisenhut P; ACIB Gmbh, Austrian Centre of Industrial Biotechnology, Vienna, Austria.; Department of Biotechnology, University of Natural Resources and Life Sciences, Vienna, Vienna, Austria.
Lee I; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, USA.
Timp W; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, USA.
Borth N; ACIB Gmbh, Austrian Centre of Industrial Biotechnology, Vienna, Austria.; Department of Biotechnology, University of Natural Resources and Life Sciences, Vienna, Vienna, Austria.
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Źródło :
Biotechnology journal [Biotechnol J] 2021 Jun; Vol. 16 (6), pp. e2000350. Date of Electronic Publication: 2021 Feb 15.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Methylation*/genetics
Epigenesis, Genetic*
Animals ; CHO Cells ; Cricetulus ; DNA ; Humans
Czasopismo naukowe
Tytuł :
Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue.
Autorzy :
Georgiadi A; Institute for Diabetes and Cancer, Helmholtz Diabetes Center, Helmholtz Centre Munich, German Research Center for Environmental Health, Neuherberg, Germany. .; Joint Heidelberg-IDC Transnational Diabetes Program, Heidelberg University Hospital, Heidelberg, Germany. .; Chair Molecular Metabolic Control, Medical Faculty, Technical University Munich, Munich, Germany. .; German Center for Diabetes Research (DZD), Neuherberg, Germany. .; Department for Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden. .
Lopez-Salazar V; Institute for Diabetes and Cancer, Helmholtz Diabetes Center, Helmholtz Centre Munich, German Research Center for Environmental Health, Neuherberg, Germany.; Joint Heidelberg-IDC Transnational Diabetes Program, Heidelberg University Hospital, Heidelberg, Germany.; Chair Molecular Metabolic Control, Medical Faculty, Technical University Munich, Munich, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.
Merahbi RE; Institute for Diabetes and Cancer, Helmholtz Diabetes Center, Helmholtz Centre Munich, German Research Center for Environmental Health, Neuherberg, Germany.; Joint Heidelberg-IDC Transnational Diabetes Program, Heidelberg University Hospital, Heidelberg, Germany.; Chair Molecular Metabolic Control, Medical Faculty, Technical University Munich, Munich, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.
Karikari RA; Institute for Diabetes and Cancer, Helmholtz Diabetes Center, Helmholtz Centre Munich, German Research Center for Environmental Health, Neuherberg, Germany.; Joint Heidelberg-IDC Transnational Diabetes Program, Heidelberg University Hospital, Heidelberg, Germany.; Chair Molecular Metabolic Control, Medical Faculty, Technical University Munich, Munich, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.
Ma X; Department for Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden.
Mourão A; Institute of Structural Biology, Helmholtz Centre Munich, German Research Center for Environmental Health, Neuherberg, Germany.
Klepac K; Institute for Diabetes and Cancer, Helmholtz Diabetes Center, Helmholtz Centre Munich, German Research Center for Environmental Health, Neuherberg, Germany.; Joint Heidelberg-IDC Transnational Diabetes Program, Heidelberg University Hospital, Heidelberg, Germany.; Chair Molecular Metabolic Control, Medical Faculty, Technical University Munich, Munich, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.
Bühler L; Institute for Diabetes and Cancer, Helmholtz Diabetes Center, Helmholtz Centre Munich, German Research Center for Environmental Health, Neuherberg, Germany.; Joint Heidelberg-IDC Transnational Diabetes Program, Heidelberg University Hospital, Heidelberg, Germany.; Chair Molecular Metabolic Control, Medical Faculty, Technical University Munich, Munich, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.
Alfaro AJ; Institute for Diabetes and Cancer, Helmholtz Diabetes Center, Helmholtz Centre Munich, German Research Center for Environmental Health, Neuherberg, Germany.; Joint Heidelberg-IDC Transnational Diabetes Program, Heidelberg University Hospital, Heidelberg, Germany.; Chair Molecular Metabolic Control, Medical Faculty, Technical University Munich, Munich, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.
Kaczmarek I; Rudolf-Schönheimer-Institute for Biochemistry, Faculty of Medicine, University of Leipzig, Leipzig, Germany.
Linford A; Institute for Diabetes and Cancer, Helmholtz Diabetes Center, Helmholtz Centre Munich, German Research Center for Environmental Health, Neuherberg, Germany.; Joint Heidelberg-IDC Transnational Diabetes Program, Heidelberg University Hospital, Heidelberg, Germany.; Chair Molecular Metabolic Control, Medical Faculty, Technical University Munich, Munich, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.
Bosma M; Department for Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden.
Shilkova O; Department for Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden.
Ritvos O; Biomedicum Helsinki and Department of Bacteriology, Haartman Institute, University of Helsinki, Helsinki, Finland.
Nakamura N; Department of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan.
Hirose S; Department of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan.
Lassi M; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Experimental Genetics, Helmholtz Diabetes Center, Helmholtz Centre Munich, German Research Center for Environmental Health, Neuherberg, Germany.
Teperino R; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Experimental Genetics, Helmholtz Diabetes Center, Helmholtz Centre Munich, German Research Center for Environmental Health, Neuherberg, Germany.
Machado J; Institute for Diabetes and Cancer, Helmholtz Diabetes Center, Helmholtz Centre Munich, German Research Center for Environmental Health, Neuherberg, Germany.; Joint Heidelberg-IDC Transnational Diabetes Program, Heidelberg University Hospital, Heidelberg, Germany.; Chair Molecular Metabolic Control, Medical Faculty, Technical University Munich, Munich, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.
Scheideler M; Institute for Diabetes and Cancer, Helmholtz Diabetes Center, Helmholtz Centre Munich, German Research Center for Environmental Health, Neuherberg, Germany.; Joint Heidelberg-IDC Transnational Diabetes Program, Heidelberg University Hospital, Heidelberg, Germany.; Chair Molecular Metabolic Control, Medical Faculty, Technical University Munich, Munich, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.
Dietrich A; Department of Surgery, University of Leipzig, Leipzig, Germany.
Geerlof A; Institute of Structural Biology, Helmholtz Centre Munich, German Research Center for Environmental Health, Neuherberg, Germany.
Feuchtinger A; Core Facility Pathology & Tissue Analytics Research Unit Analytical Pathology, Helmholtz Centre Munich, German Research Center for Environmental Health, Neuherberg, Germany.
Blutke A; Core Facility Pathology & Tissue Analytics Research Unit Analytical Pathology, Helmholtz Centre Munich, German Research Center for Environmental Health, Neuherberg, Germany.
Fischer K; Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Centre Munich, German Research Center for Environmental Health, Neuherberg, Germany.
Müller TD; Institute for Diabetes and Obesity, Helmholtz Diabetes Center, Helmholtz Centre Munich, German Research Center for Environmental Health, Neuherberg, Germany.
Kessler K; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.; Department of Endocrinology, Diabetes and Nutrition, Campus Benjamin Franklin, Charité University of Medicine, Berlin, Germany.; Biomineral Research Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.
Schöneberg T; Rudolf-Schönheimer-Institute for Biochemistry, Faculty of Medicine, University of Leipzig, Leipzig, Germany.
Thor D; Rudolf-Schönheimer-Institute for Biochemistry, Faculty of Medicine, University of Leipzig, Leipzig, Germany.
Hornemann S; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
Kruse M; Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.; Department of Endocrinology, Diabetes and Nutrition, Campus Benjamin Franklin, Charité University of Medicine, Berlin, Germany.
Nawroth P; Institute for Diabetes and Cancer, Helmholtz Diabetes Center, Helmholtz Centre Munich, German Research Center for Environmental Health, Neuherberg, Germany.; Joint Heidelberg-IDC Transnational Diabetes Program, Heidelberg University Hospital, Heidelberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.
Pivovarova-Ramich O; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.; Department of Endocrinology, Diabetes and Nutrition, Campus Benjamin Franklin, Charité University of Medicine, Berlin, Germany.; Research Group Molecular Nutritional Medicine, Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
Pfeiffer AFH; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.; Department of Endocrinology, Diabetes and Nutrition, Campus Benjamin Franklin, Charité University of Medicine, Berlin, Germany.
Sattler M; Institute of Structural Biology, Helmholtz Centre Munich, German Research Center for Environmental Health, Neuherberg, Germany.
Blüher M; Department of Medicine, University of Leipzig, Leipzig, Germany.
Herzig S; Institute for Diabetes and Cancer, Helmholtz Diabetes Center, Helmholtz Centre Munich, German Research Center for Environmental Health, Neuherberg, Germany. .; Joint Heidelberg-IDC Transnational Diabetes Program, Heidelberg University Hospital, Heidelberg, Germany. .; Chair Molecular Metabolic Control, Medical Faculty, Technical University Munich, Munich, Germany. .; German Center for Diabetes Research (DZD), Neuherberg, Germany. .
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Źródło :
Nature communications [Nat Commun] 2021 May 20; Vol. 12 (1), pp. 2999. Date of Electronic Publication: 2021 May 20.
Typ publikacji :
Journal Article; Observational Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Adipose Tissue, White/*metabolism
Membrane Proteins/*metabolism
Prediabetic State/*metabolism
Proteins/*metabolism
Receptors, G-Protein-Coupled/*metabolism
3T3-L1 Cells ; Adipocytes/metabolism ; Adipose Tissue, White/cytology ; Adolescent ; Adult ; Aged ; Animals ; CHO Cells ; Cohort Studies ; Cricetulus ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Type 2/prevention & control ; Diet, High-Fat/adverse effects ; Disease Models, Animal ; Female ; Gene Knockdown Techniques ; Glucose/metabolism ; HEK293 Cells ; Hep G2 Cells ; Humans ; Insulin/metabolism ; Insulin Resistance ; Islets of Langerhans/metabolism ; Liver/metabolism ; Male ; Membrane Proteins/administration & dosage ; Membrane Proteins/blood ; Membrane Proteins/genetics ; Mice ; Mice, Knockout ; Middle Aged ; NIH 3T3 Cells ; Prediabetic State/blood ; Prediabetic State/drug therapy ; Prediabetic State/etiology ; Primary Cell Culture ; Proteins/analysis ; Receptors, G-Protein-Coupled/blood ; Receptors, G-Protein-Coupled/genetics ; Recombinant Fusion Proteins/administration & dosage ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/isolation & purification ; Young Adult
Czasopismo naukowe
Tytuł :
Occurrence and toxicity of halobenzoquinones as drinking water disinfection byproducts.
Autorzy :
Wu H; Department of Occupational and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, PR China.
Long K; Department of Occupational and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, PR China.
Sha Y; Department of Occupational and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, PR China.
Lu D; Department of Occupational and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, PR China.
Xia Y; Department of Occupational and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, PR China.
Mo Y; Department of Occupational and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, PR China.
Yang Q; Department of Occupational and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, PR China.
Zheng W; Key Laboratory of the Public Health Safety, Ministry of Education, Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, PR China.
Yang M; College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518000, PR China.
Wei X; Department of Occupational and Environmental Health, School of Public Health, Guangxi Medical University, Nanning 530021, PR China. Electronic address: .
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Źródło :
The Science of the total environment [Sci Total Environ] 2021 May 20; Vol. 770, pp. 145277. Date of Electronic Publication: 2021 Jan 21.
Typ publikacji :
Journal Article
MeSH Terms :
Disinfectants*/toxicity
Drinking Water*
Water Pollutants, Chemical*/analysis
Water Pollutants, Chemical*/toxicity
Water Purification*
Animals ; CHO Cells ; China ; Cricetinae ; Cricetulus ; Disinfection ; Halogenation
Czasopismo naukowe
Tytuł :
Exploring the molecular content of CHO exosomes during bioprocessing.
Autorzy :
Keysberg C; Bielefeld University, Bielefeld, Germany. .; University of Applied Sciences Biberach, Biberach, Germany. .
Hertel O; Bielefeld University, Bielefeld, Germany.; Center for Biotechnology (CeBiTec), Bielefeld University, Bielefeld, Germany.
Schelletter L; Bielefeld University, Bielefeld, Germany.; Center for Biotechnology (CeBiTec), Bielefeld University, Bielefeld, Germany.
Busche T; Center for Biotechnology (CeBiTec), Bielefeld University, Bielefeld, Germany.
Sochart C; Bielefeld University, Bielefeld, Germany.
Kalinowski J; Center for Biotechnology (CeBiTec), Bielefeld University, Bielefeld, Germany.
Hoffrogge R; Bielefeld University, Bielefeld, Germany.; Center for Biotechnology (CeBiTec), Bielefeld University, Bielefeld, Germany.
Otte K; University of Applied Sciences Biberach, Biberach, Germany.
Noll T; Bielefeld University, Bielefeld, Germany.; Center for Biotechnology (CeBiTec), Bielefeld University, Bielefeld, Germany.
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Źródło :
Applied microbiology and biotechnology [Appl Microbiol Biotechnol] 2021 May; Vol. 105 (9), pp. 3673-3689. Date of Electronic Publication: 2021 May 03.
Typ publikacji :
Journal Article
MeSH Terms :
Exosomes*
Animals ; CHO Cells ; Cricetinae ; Cricetulus ; Proteome ; Proteomics
Czasopismo naukowe
Tytuł :
A comprehensive antigen production and characterisation study for easy-to-implement, specific and quantitative SARS-CoV-2 serotests.
Autorzy :
Klausberger M; Department of Biotechnology, University of Natural Resources and Life Sciences (BOKU) Vienna, Muthgasse 18, 1190 Vienna, Austria.
Duerkop M; Department of Biotechnology, University of Natural Resources and Life Sciences (BOKU) Vienna, Muthgasse 18, 1190 Vienna, Austria; Novasign GmbH Vienna, Austria.
Haslacher H; Department of Laboratory Medicine, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria.
Wozniak-Knopp G; Department of Biotechnology, University of Natural Resources and Life Sciences (BOKU) Vienna, Muthgasse 18, 1190 Vienna, Austria; CD Laboratory for innovative Immunotherapeutics, Vienna, Austria.
Cserjan-Puschmann M; Department of Biotechnology, University of Natural Resources and Life Sciences (BOKU) Vienna, Muthgasse 18, 1190 Vienna, Austria; ACIB-Austrian Centre of Industrial Biotechnology, Graz, Austria.
Perkmann T; Department of Laboratory Medicine, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria.
Lingg N; Department of Biotechnology, University of Natural Resources and Life Sciences (BOKU) Vienna, Muthgasse 18, 1190 Vienna, Austria; ACIB-Austrian Centre of Industrial Biotechnology, Graz, Austria.
Aguilar PP; Department of Biotechnology, University of Natural Resources and Life Sciences (BOKU) Vienna, Muthgasse 18, 1190 Vienna, Austria; ACIB-Austrian Centre of Industrial Biotechnology, Graz, Austria.
Laurent E; Department of Biotechnology, University of Natural Resources and Life Sciences (BOKU) Vienna, Muthgasse 18, 1190 Vienna, Austria; BOKU Core Facility Biomolecular & Cellular Analysis, University of Natural Resources and Life Sciences (BOKU),Vienna, Austria.
De Vos J; Department of Biotechnology, University of Natural Resources and Life Sciences (BOKU) Vienna, Muthgasse 18, 1190 Vienna, Austria; Department of Chemical Engineering, Vrije Universiteit Brussel (VUB), Brussels, Belgium.
Hofner M; Competence Unit Molecular Diagnostics, Center for Health and Bioresources, AIT Austrian Institute of Technology GmbH, Vienna, Austria.
Holzer B; Austrian Agency for Health and Food Safety (AGES), Department for Animal Health, Moedling, Austria.
Stadler M; Institute of Immunology, University of Veterinary Medicine, Vienna, Austria.
Manhart G; Institute for Medical Biochemistry, University of Veterinary Medicine, Veterinärplatz 1, 1210 Vienna, Austria.
Vierlinger K; Competence Unit Molecular Diagnostics, Center for Health and Bioresources, AIT Austrian Institute of Technology GmbH, Vienna, Austria.
Egger M; Department of Laboratory Medicine, Konventhospital Barmherzige Brueder Linz and Ordensklinikum Linz Barmherzige Schwestern, Linz, Austria.
Milchram L; Competence Unit Molecular Diagnostics, Center for Health and Bioresources, AIT Austrian Institute of Technology GmbH, Vienna, Austria.
Gludovacz E; Department of Biotechnology, University of Natural Resources and Life Sciences (BOKU) Vienna, Muthgasse 18, 1190 Vienna, Austria.
Marx N; Department of Biotechnology, University of Natural Resources and Life Sciences (BOKU) Vienna, Muthgasse 18, 1190 Vienna, Austria.
Köppl C; Department of Biotechnology, University of Natural Resources and Life Sciences (BOKU) Vienna, Muthgasse 18, 1190 Vienna, Austria; ACIB-Austrian Centre of Industrial Biotechnology, Graz, Austria.
Tauer C; Department of Biotechnology, University of Natural Resources and Life Sciences (BOKU) Vienna, Muthgasse 18, 1190 Vienna, Austria.
Beck J; Department of Biotechnology, University of Natural Resources and Life Sciences (BOKU) Vienna, Muthgasse 18, 1190 Vienna, Austria.
Maresch D; BOKU Core Facility Mass Spectrometry, University of Natural Resources and Life Sciences (BOKU), Vienna, Austria.
Grünwald-Gruber C; BOKU Core Facility Mass Spectrometry, University of Natural Resources and Life Sciences (BOKU), Vienna, Austria; Department of Chemistry, University of Natural Resources and Life Sciences (BOKU) Vienna, Austria.
Strobl F; enGenes Biotech GmbH, Vienna, Austria.
Satzer P; Department of Biotechnology, University of Natural Resources and Life Sciences (BOKU) Vienna, Muthgasse 18, 1190 Vienna, Austria; ACIB-Austrian Centre of Industrial Biotechnology, Graz, Austria.
Stadlmayr G; Department of Biotechnology, University of Natural Resources and Life Sciences (BOKU) Vienna, Muthgasse 18, 1190 Vienna, Austria; CD Laboratory for innovative Immunotherapeutics, Vienna, Austria.
Vavra U; Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences (BOKU) Vienna, Austria.
Huber J; Competence Unit Molecular Diagnostics, Center for Health and Bioresources, AIT Austrian Institute of Technology GmbH, Vienna, Austria.
Wahrmann M; Department of Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, Austria.
Eskandary F; Department of Medicine III, Division of Nephrology and Dialysis, Medical University of Vienna, Austria.
Breyer MK; Department of Respiratory and Critical Care Medicine and Ludwig Boltzmann Institute for Lung Health, Otto Wagner Hospital, Vienna, Austria.
Sieghart D; Division of Rheumatology, Department of Medicine III, Medical University of Vienna, Austria.
Quehenberger P; Department of Laboratory Medicine, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria.
Leitner G; Department of Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Austria.
Strassl R; Department of Laboratory Medicine, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria.
Egger AE; Central Institute for Medical and Chemical Laboratory Diagnosis, Innsbruck University Hospital, Innsbruck, Austria.
Irsara C; Central Institute for Medical and Chemical Laboratory Diagnosis, Innsbruck University Hospital, Innsbruck, Austria.
Griesmacher A; Central Institute for Medical and Chemical Laboratory Diagnosis, Innsbruck University Hospital, Innsbruck, Austria.
Hoermann G; Central Institute for Medical and Chemical Laboratory Diagnosis, Innsbruck University Hospital, Innsbruck, Austria; MLL Munich Leukemia Laboratory, Munich, Germany.
Weiss G; Department of Internal Medicine II, Innsbruck Medical University, Innsbruck, Austria.
Bellmann-Weiler R; Department of Internal Medicine II, Innsbruck Medical University, Innsbruck, Austria.
Loeffler-Ragg J; Department of Internal Medicine II, Innsbruck Medical University, Innsbruck, Austria.
Borth N; Department of Biotechnology, University of Natural Resources and Life Sciences (BOKU) Vienna, Muthgasse 18, 1190 Vienna, Austria.
Strasser R; Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences (BOKU) Vienna, Austria.
Jungbauer A; Department of Biotechnology, University of Natural Resources and Life Sciences (BOKU) Vienna, Muthgasse 18, 1190 Vienna, Austria; ACIB-Austrian Centre of Industrial Biotechnology, Graz, Austria.
Hahn R; Department of Biotechnology, University of Natural Resources and Life Sciences (BOKU) Vienna, Muthgasse 18, 1190 Vienna, Austria; ACIB-Austrian Centre of Industrial Biotechnology, Graz, Austria.
Mairhofer J; enGenes Biotech GmbH, Vienna, Austria.
Hartmann B; Austrian Agency for Health and Food Safety (AGES), Department for Animal Health, Moedling, Austria.
Binder NB; Technoclone Herstellung von Diagnostika und Arzneimitteln GmbH, Vienna, Austria.
Striedner G; Department of Biotechnology, University of Natural Resources and Life Sciences (BOKU) Vienna, Muthgasse 18, 1190 Vienna, Austria; Novasign GmbH Vienna, Austria; ACIB-Austrian Centre of Industrial Biotechnology, Graz, Austria; enGenes Biotech GmbH, Vienna, Austria.
Mach L; Department of Applied Genetics and Cell Biology, University of Natural Resources and Life Sciences (BOKU) Vienna, Austria.
Weinhäusel A; Competence Unit Molecular Diagnostics, Center for Health and Bioresources, AIT Austrian Institute of Technology GmbH, Vienna, Austria.
Dieplinger B; Department of Laboratory Medicine, Konventhospital Barmherzige Brueder Linz and Ordensklinikum Linz Barmherzige Schwestern, Linz, Austria.
Grebien F; Institute for Medical Biochemistry, University of Veterinary Medicine, Veterinärplatz 1, 1210 Vienna, Austria. Electronic address: .
Gerner W; Institute of Immunology, University of Veterinary Medicine, Vienna, Austria; Christian Doppler Laboratory for an Optimized Prediction of Vaccination Success in Pigs, University of Veterinary Medicine, Vienna, Austria; Present address: The Pirbright Institute, Pirbright, United Kingdom.
Binder CJ; Department of Laboratory Medicine, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria. Electronic address: .
Grabherr R; Department of Biotechnology, University of Natural Resources and Life Sciences (BOKU) Vienna, Muthgasse 18, 1190 Vienna, Austria. Electronic address: .
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Źródło :
EBioMedicine [EBioMedicine] 2021 May; Vol. 67, pp. 103348. Date of Electronic Publication: 2021 Apr 25.
Typ publikacji :
Journal Article; Multicenter Study
MeSH Terms :
Antibodies, Viral/*blood
COVID-19/*diagnosis
COVID-19 Serological Testing/*methods
Coronavirus Nucleocapsid Proteins/*immunology
SARS-CoV-2/*immunology
Spike Glycoprotein, Coronavirus/*chemistry
Spike Glycoprotein, Coronavirus/*immunology
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Animals ; Binding Sites ; CHO Cells ; COVID-19/immunology ; Cricetulus ; Early Diagnosis ; HEK293 Cells ; Humans ; Immunoglobulin G/blood ; Middle Aged ; Sensitivity and Specificity ; Young Adult
Czasopismo naukowe
Tytuł :
Comprehensive characterization of dihydrofolate reductase-mediated gene amplification for the establishment of recombinant human embryonic kidney 293 cells producing monoclonal antibodies.
Autorzy :
Lee SY; Department of Biological Sciences, KAIST, Yuseong-gu, Daejeon, Republic of Korea.
Baek M; Department of Biological Sciences, KAIST, Yuseong-gu, Daejeon, Republic of Korea.
Lee GM; Department of Biological Sciences, KAIST, Yuseong-gu, Daejeon, Republic of Korea.
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Źródło :
Biotechnology journal [Biotechnol J] 2021 May; Vol. 16 (5), pp. e2000351. Date of Electronic Publication: 2020 Dec 30.
Typ publikacji :
Journal Article
MeSH Terms :
Antibodies, Monoclonal*/genetics
Tetrahydrofolate Dehydrogenase*/genetics
Animals ; CHO Cells ; Cricetinae ; Gene Amplification ; HEK293 Cells ; Humans ; Kidney ; Methotrexate/pharmacology
Czasopismo naukowe
Tytuł :
High level stable expression of recombinant HIV gp120 in glutamine synthetase gene deficient HEK293T cells.
Autorzy :
Zou Z; Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA.
Wang R; Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA.
Go EP; Department of Chemistry, University of Kansas, Lawrence, KS, 66047, USA.
Desaire H; Department of Chemistry, University of Kansas, Lawrence, KS, 66047, USA.
Sun PD; Structural Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, 20852, USA. Electronic address: .
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Źródło :
Protein expression and purification [Protein Expr Purif] 2021 May; Vol. 181, pp. 105837. Date of Electronic Publication: 2021 Jan 30.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms :
Glutamate-Ammonia Ligase/*genetics
HIV Envelope Protein gp120/*metabolism
HIV-1/*metabolism
Animals ; CHO Cells ; CRISPR-Cas Systems ; Codon ; Cricetulus ; Gene Knockdown Techniques ; HEK293 Cells ; Humans ; Protein Sorting Signals ; Recombinant Proteins/metabolism
Czasopismo naukowe
Tytuł :
Mixing and oxygen transfer characteristics of a microplate bioreactor with surface-attached microposts.
Autorzy :
Fisher JT; Department of Chemical Engineering, Villanova University, Villanova, Pennsylvania, 19085, USA.
Gurney TO; Redbud Labs Inc., Research Triangle Park, North Carolina, 27709, USA.
Mason BM; Redbud Labs Inc., Research Triangle Park, North Carolina, 27709, USA.
Fisher JK; Redbud Labs Inc., Research Triangle Park, North Carolina, 27709, USA.
Kelly WJ; Department of Chemical Engineering, Villanova University, Villanova, Pennsylvania, 19085, USA.
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Źródło :
Biotechnology journal [Biotechnol J] 2021 May; Vol. 16 (5), pp. e2000257. Date of Electronic Publication: 2021 Mar 11.
Typ publikacji :
Journal Article
MeSH Terms :
Bioreactors*
Oxygen*
Animals ; CHO Cells ; Cricetinae ; Cricetulus ; Culture Media
Czasopismo naukowe
Tytuł :
Using continuous chromatography methodology to achieve high-productivity and high-purity enrichment of charge variants for analytical characterization.
Autorzy :
Bigelow E; Biologics Development, Bristol Myers Squibb, 38 Jackson Road, Devens, MA 01434. Electronic address: .
Song Y; Biologics Development, Bristol Myers Squibb, 38 Jackson Road, Devens, MA 01434.
Chen J; Biologics Development, Bristol Myers Squibb, 38 Jackson Road, Devens, MA 01434.
Holstein M; Biologics Development, Bristol Myers Squibb, 38 Jackson Road, Devens, MA 01434.
Huang Y; Biologics Development, Bristol Myers Squibb, 1 Squibb Drive, New Brunswick, NJ 08901.
Duhamel L; Biologics Development, Bristol Myers Squibb, 38 Jackson Road, Devens, MA 01434.
Stone K; Biologics Development, Bristol Myers Squibb, 38 Jackson Road, Devens, MA 01434.
Furman R; Biologics Development, Bristol Myers Squibb, 1 Squibb Drive, New Brunswick, NJ 08901.
Li ZJ; Biologics Development, Bristol Myers Squibb, 38 Jackson Road, Devens, MA 01434.
Ghose S; Biologics Development, Bristol Myers Squibb, 38 Jackson Road, Devens, MA 01434.
Pokaż więcej
Źródło :
Journal of chromatography. A [J Chromatogr A] 2021 Apr 26; Vol. 1643, pp. 462008. Date of Electronic Publication: 2021 Mar 18.
Typ publikacji :
Journal Article
MeSH Terms :
Chromatography, High Pressure Liquid/*methods
Animals ; Antibodies, Monoclonal/isolation & purification ; CHO Cells ; Chemical Fractionation ; Cricetulus ; Electrophoresis, Capillary ; Glycosylation ; Mass Spectrometry ; Molecular Weight ; Peptide Mapping ; Solvents/chemistry
Czasopismo naukowe
Tytuł :
Therapeutic Efficacy of Lactonic Sophorolipids: Nanoceria-Assisted Combination Therapy of NSCLC using HDAC and Hsp90 Inhibitors.
Autorzy :
Naz S; Department of Chemistry, Pittsburg State University, Pittsburg, Kansas 66762, United States.
Banerjee T; Department of Chemistry, Pittsburg State University, Pittsburg, Kansas 66762, United States.
Totsingan F; Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, New York 12180, United States.
Woody K; Department of Chemistry, Pittsburg State University, Pittsburg, Kansas 66762, United States.
Gross RA; Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, New York 12180, United States.
Santra S; Department of Chemistry, Pittsburg State University, Pittsburg, Kansas 66762, United States.
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Źródło :
Nanotheranostics [Nanotheranostics] 2021 Apr 16; Vol. 5 (4), pp. 391-404. Date of Electronic Publication: 2021 Apr 16 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Cerium*
Glycolipids*
Histone Deacetylase Inhibitors*
Carcinoma, Non-Small-Cell Lung/*metabolism
Lung Neoplasms/*metabolism
A549 Cells ; Animals ; Antineoplastic Agents ; Antioxidants ; CHO Cells ; Combined Modality Therapy ; Cricetinae ; Cricetulus ; HSP90 Heat-Shock Proteins/antagonists & inhibitors ; Humans ; Triazoles
Czasopismo naukowe
Tytuł :
The antigenic anatomy of SARS-CoV-2 receptor binding domain.
Autorzy :
Dejnirattisai W; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK.
Zhou D; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford OX3 7BN, UK.
Ginn HM; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot OX11 0DE, UK.
Duyvesteyn HME; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford OX3 7BN, UK.
Supasa P; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK.
Case JB; Department of Medicine, Washington University School of Medicine, St. Louis, St. Louis, MO 63110, USA.
Zhao Y; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford OX3 7BN, UK.
Walter TS; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford OX3 7BN, UK.
Mentzer AJ; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Liu C; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford OX3 7FZ, UK.
Wang B; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK.
Paesen GC; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford OX3 7BN, UK.
Slon-Campos J; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK.
López-Camacho C; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK.
Kafai NM; Department of Medicine, Washington University School of Medicine, St. Louis, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, St. Louis, MO 63110, USA.
Bailey AL; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, St. Louis, MO 63110, USA.
Chen RE; Department of Medicine, Washington University School of Medicine, St. Louis, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, St. Louis, MO 63110, USA.
Ying B; Department of Medicine, Washington University School of Medicine, St. Louis, St. Louis, MO 63110, USA.
Thompson C; Peter Medawar Building for Pathogen Research, Oxford OX1 3SY, UK; Department of Zoology, University of Oxford, Oxford OX1 3SZ, UK.
Bolton J; Department of Zoology, University of Oxford, Oxford OX1 3SZ, UK.
Fyfe A; Peter Medawar Building for Pathogen Research, Oxford OX1 3SY, UK; Department of Zoology, University of Oxford, Oxford OX1 3SZ, UK.
Gupta S; Peter Medawar Building for Pathogen Research, Oxford OX1 3SY, UK; Department of Zoology, University of Oxford, Oxford OX1 3SZ, UK.
Tan TK; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK.
Gilbert-Jaramillo J; Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.
James W; Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.
Knight M; Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.
Carroll MW; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK; National Infection Service, Public Health England (PHE), Porton Down, Salisbury SP4 0JG, UK.
Skelly D; Oxford University Hospitals NHS Foundation Trust, Oxford, UK; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK.
Dold C; Department of Paediatrics, Oxford Vaccine Group, University of Oxford, Oxford OX3 7LE, UK; NIHR Oxford Biomedical Research Centre, Oxford OX3 9DU, UK.
Peng Y; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK.
Levin R; Worthing Hospital, Worthing BN11 2DH, UK.
Dong T; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford OX3 7FZ, UK; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK; Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.
Pollard AJ; Oxford University Hospitals NHS Foundation Trust, Oxford, UK; Department of Paediatrics, Oxford Vaccine Group, University of Oxford, Oxford OX3 7LE, UK; NIHR Oxford Biomedical Research Centre, Oxford OX3 9DU, UK.
Knight JC; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Klenerman P; Oxford University Hospitals NHS Foundation Trust, Oxford, UK; Peter Medawar Building for Pathogen Research, Oxford OX1 3SY, UK; NIHR Oxford Biomedical Research Centre, Oxford OX3 9DU, UK; Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, UK.
Temperton N; Viral Pseudotype Unit, Medway School of Pharmacy, University of Kent, Chatham ME4 4TB, UK.
Hall DR; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot OX11 0DE, UK.
Williams MA; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot OX11 0DE, UK.
Paterson NG; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot OX11 0DE, UK.
Bertram FKR; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot OX11 0DE, UK.
Siebert CA; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot OX11 0DE, UK.
Clare DK; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot OX11 0DE, UK.
Howe A; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot OX11 0DE, UK.
Radecke J; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot OX11 0DE, UK.
Song Y; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot OX11 0DE, UK.
Townsend AR; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford OX3 7FZ, UK; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK.
Huang KA; Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Fry EE; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford OX3 7BN, UK.
Mongkolsapaya J; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford OX3 7FZ, UK; Siriraj Center of Research Excellence in Dengue & Emerging Pathogens, Dean Office for Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand. Electronic address: .
Diamond MS; Department of Medicine, Washington University School of Medicine, St. Louis, St. Louis, MO 63110, USA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, St. Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, St. Louis, MO 63110, USA; The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, St. Louis, MO 63110 USA. Electronic address: .
Ren J; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford OX3 7BN, UK. Electronic address: .
Stuart DI; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Headington, Oxford OX3 7BN, UK; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford OX3 7FZ, UK; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot OX11 0DE, UK; Instruct-ERIC, Oxford House, Parkway Court, John Smith Drive, Oxford OX4 2JY, UK. Electronic address: .
Screaton GR; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7BN, UK; Oxford University Hospitals NHS Foundation Trust, Oxford, UK. Electronic address: .
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Źródło :
Cell [Cell] 2021 Apr 15; Vol. 184 (8), pp. 2183-2200.e22. Date of Electronic Publication: 2021 Feb 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Monoclonal/*immunology
Antibodies, Neutralizing/*immunology
Antibodies, Viral/*immunology
COVID-19/*immunology
Spike Glycoprotein, Coronavirus/*immunology
Animals ; Binding Sites, Antibody ; CHO Cells ; Chlorocebus aethiops ; Cricetulus ; Epitopes ; Female ; HEK293 Cells ; Humans ; Male ; Mice ; Mice, Transgenic ; Models, Molecular ; Protein Binding ; Protein Structure, Tertiary ; SARS-CoV-2/immunology ; Vero Cells
Czasopismo naukowe
Tytuł :
Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera.
Autorzy :
Supasa P; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Zhou D; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK.
Dejnirattisai W; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Liu C; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.
Mentzer AJ; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK; Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
Ginn HM; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK.
Zhao Y; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK.
Duyvesteyn HME; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK.
Nutalai R; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Tuekprakhon A; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Wang B; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Paesen GC; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK.
Slon-Campos J; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
López-Camacho C; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Hallis B; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, UK.
Coombes N; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, UK.
Bewley KR; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, UK.
Charlton S; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, UK.
Walter TS; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK.
Barnes E; Oxford University Hospitals NHS Foundation Trust, Oxford, UK; Peter Medawar Building for Pathogen Research, Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK; Translational Gastroenterology Unit, University of Oxford, Oxford, UK.
Dunachie SJ; Oxford University Hospitals NHS Foundation Trust, Oxford, UK; Peter Medawar Building for Pathogen Research, Oxford, UK; Centre For Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK; Mahidol-Oxford Tropical Medicine Research Unit, Bangkok, Thailand.
Skelly D; Oxford University Hospitals NHS Foundation Trust, Oxford, UK; Peter Medawar Building for Pathogen Research, Oxford, UK; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Lumley SF; Oxford University Hospitals NHS Foundation Trust, Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK; Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Baker N; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, UK.
Shaik I; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, UK.
Humphries HE; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, UK.
Godwin K; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, UK.
Gent N; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, UK.
Sienkiewicz A; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, UK.
Dold C; NIHR Oxford Biomedical Research Centre, Oxford, UK; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
Levin R; Worthing Hospital, Worthing, UK.
Dong T; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK; Nuffield Department of Medicine, University of Oxford, Oxford, UK; MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Pollard AJ; NIHR Oxford Biomedical Research Centre, Oxford, UK; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
Knight JC; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK; Oxford University Hospitals NHS Foundation Trust, Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK.
Klenerman P; Oxford University Hospitals NHS Foundation Trust, Oxford, UK; Peter Medawar Building for Pathogen Research, Oxford, UK; NIHR Oxford Biomedical Research Centre, Oxford, UK; Translational Gastroenterology Unit, University of Oxford, Oxford, UK.
Crook D; Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Lambe T; Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Clutterbuck E; NIHR Oxford Biomedical Research Centre, Oxford, UK; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
Bibi S; NIHR Oxford Biomedical Research Centre, Oxford, UK; Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, UK.
Flaxman A; Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Bittaye M; Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Belij-Rammerstorfer S; Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Gilbert S; Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Hall DR; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK.
Williams MA; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK.
Paterson NG; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK.
James W; Sir William Dunn School of Pathology University of Oxford, Oxford, UK.
Carroll MW; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK; National Infection Service, Public Health England (PHE), Porton Down, Salisbury, UK.
Fry EE; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK.
Mongkolsapaya J; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK; Siriraj Center of Research Excellence in Dengue & Emerging Pathogens, Dean Office for Research, Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand. Electronic address: .
Ren J; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK. Electronic address: .
Stuart DI; Division of Structural Biology, Nuffield Department of Medicine, University of Oxford, The Wellcome Centre for Human Genetics, Oxford, UK; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK; Diamond Light Source Ltd, Harwell Science & Innovation Campus, Didcot, UK; Instruct-ERIC, Oxford House, Parkway Court, John Smith Drive, Oxford, UK. Electronic address: .
Screaton GR; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK; Chinese Academy of Medical Science (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK. Electronic address: .
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Źródło :
Cell [Cell] 2021 Apr 15; Vol. 184 (8), pp. 2201-2211.e7. Date of Electronic Publication: 2021 Feb 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Monoclonal/*immunology
Antibodies, Neutralizing/*immunology
Antibodies, Viral/*immunology
COVID-19/*immunology
SARS-CoV-2/*immunology
Spike Glycoprotein, Coronavirus/*immunology
Animals ; Antibodies, Neutralizing/blood ; Antibodies, Viral/blood ; CHO Cells ; COVID-19/epidemiology ; Chlorocebus aethiops ; Cricetulus ; HEK293 Cells ; Humans ; Pandemics ; Protein Binding ; Structure-Activity Relationship ; Vero Cells
SCR Organism :
SARS-CoV-2 variants
Czasopismo naukowe
Tytuł :
Co-condensation between transcription factor and coactivator p300 modulates transcriptional bursting kinetics.
Autorzy :
Ma L; Center for Quantitative Biology and Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China; The MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University, Beijing 100871, China.
Gao Z; Center for Quantitative Biology and Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China; The MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University, Beijing 100871, China.
Wu J; Center for Quantitative Biology and Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China; The MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University, Beijing 100871, China; School of Life Sciences, Tsinghua University, Beijing 100084, China.
Zhong B; Center for Quantitative Biology and Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China; The MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University, Beijing 100871, China; School of Life Sciences, Tsinghua University, Beijing 100084, China.
Xie Y; College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.
Huang W; Center for Quantitative Biology and Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China; The MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University, Beijing 100871, China.
Lin Y; Center for Quantitative Biology and Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China; The MOE Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University, Beijing 100871, China. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Apr 15; Vol. 81 (8), pp. 1682-1697.e7. Date of Electronic Publication: 2021 Mar 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
E1A-Associated p300 Protein/*metabolism
Transcription Factors/*metabolism
Transcription, Genetic/*genetics
Transcriptional Activation/*genetics
Acetylation ; Animals ; CHO Cells ; CREB-Binding Protein/metabolism ; Cell Line ; Cricetulus ; Gene Expression Regulation/genetics ; HEK293 Cells ; Histones/metabolism ; Humans ; Kinetics ; Mice ; Trans-Activators/metabolism
Czasopismo naukowe
Tytuł :
Formation of nitro(so) and chlorinated products and toxicity alteration during the UV/monochloramine treatment of phenol.
Autorzy :
Chen C; Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology, School of Environmental Science and Engineering, Sun Yat-Sen University, Guangzhou, 510275, PR China.
Du Y; Shenzhen Environmental Science and New Energy Technology Engineering Laboratory, Tsinghua-Berkeley Shenzhen Institute, Shenzhen, 518055, PR China.
Zhou Y; Hainan Provincial Department of Ecological Environment, Haikou, 570203, PR China.
Wu Q; Shenzhen Environmental Science and New Energy Technology Engineering Laboratory, Tsinghua-Berkeley Shenzhen Institute, Shenzhen, 518055, PR China.
Zheng S; State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin, 150090, PR China.
Fang J; Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology, School of Environmental Science and Engineering, Sun Yat-Sen University, Guangzhou, 510275, PR China. Electronic address: .
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Źródło :
Water research [Water Res] 2021 Apr 15; Vol. 194, pp. 116914. Date of Electronic Publication: 2021 Feb 08.
Typ publikacji :
Journal Article
MeSH Terms :
Water Pollutants, Chemical*/analysis
Water Pollutants, Chemical*/toxicity
Water Purification*
Animals ; CHO Cells ; Chloramines ; Chlorine ; Cricetinae ; Cricetulus ; Disinfection ; Halogenation ; Phenol ; Phenols ; Ultraviolet Rays
Czasopismo naukowe
Tytuł :
Antibody Screening System Using a Herpes Simplex Virus (HSV)-Based Probe To Identify a Novel Target for Receptor-Retargeted Oncolytic HSVs.
Autorzy :
Ikeda H; Project Division of Cancer Biomolecular Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Division of Bioengineering, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Laboratory of Oncology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.; Immune Regulation Laboratory, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.
Uchida H; Project Division of Cancer Biomolecular Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan .; Division of Bioengineering, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Laboratory of Oncology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.
Okubo Y; Division of Bioengineering, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Laboratory of Oncology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.
Shibata T; Project Division of Cancer Biomolecular Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Division of Bioengineering, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Laboratory of Oncology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.
Sasaki Y; Project Division of Cancer Biomolecular Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Division of Bioengineering, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Suzuki T; Project Division of Cancer Biomolecular Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Division of Bioengineering, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Laboratory of Oncology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.
Hamada-Uematsu M; Project Division of Cancer Biomolecular Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Division of Bioengineering, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Hamasaki R; Project Division of Cancer Biomolecular Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Division of Bioengineering, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Ono Pharmaceutical Co., Ltd., Osaka, Japan.
Okuda K; Project Division of Cancer Biomolecular Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Ono Pharmaceutical Co., Ltd., Osaka, Japan.
Yamaguchi M; Department of Molecular Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Hokkaido, Japan.
Kojima M; Bioinformatics Laboratory, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.
Tanaka M; Immune Regulation Laboratory, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.
Hamada H; Laboratory of Oncology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.; Department of Molecular Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Hokkaido, Japan.
Tahara H; Project Division of Cancer Biomolecular Therapy, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Division of Bioengineering, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.; Department of Cancer Drug Discovery and Development, Osaka International Cancer Institute, Osaka, Japan.
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Źródło :
Journal of virology [J Virol] 2021 Apr 12; Vol. 95 (9). Date of Electronic Publication: 2021 Apr 12 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Virus Internalization*
Epiregulin/*metabolism
Herpesvirus 1, Human/*metabolism
Oncolytic Viruses/*physiology
Single-Chain Antibodies/*metabolism
Viral Envelope Proteins/*metabolism
Animals ; CHO Cells ; Cell Line, Tumor ; Chlorocebus aethiops ; Cricetulus ; Humans ; Neoplasms/therapy ; Oncolytic Virotherapy ; Vero Cells ; Viral Tropism
Czasopismo naukowe
Tytuł :
Crystal Structure and Subsequent Ligand Design of a Nonriboside Partial Agonist Bound to the Adenosine A 2A Receptor.
Autorzy :
Amelia T; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands.; School of Pharmacy, Bandung Institute of Technology, Jalan Ganesha 10, 40132 Bandung, Indonesia.
van Veldhoven JPD; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands.
Falsini M; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands.
Liu R; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands.
Heitman LH; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands.
van Westen GJP; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands.
Segala E; Sosei Heptares, Steinmetz Building, Granta Park, Cambridge CB21 6DG, United Kingdom.
Verdon G; Sosei Heptares, Steinmetz Building, Granta Park, Cambridge CB21 6DG, United Kingdom.
Cheng RKY; Sosei Heptares, Steinmetz Building, Granta Park, Cambridge CB21 6DG, United Kingdom.
Cooke RM; Sosei Heptares, Steinmetz Building, Granta Park, Cambridge CB21 6DG, United Kingdom.
van der Es D; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands.
IJzerman AP; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Apr 08; Vol. 64 (7), pp. 3827-3842. Date of Electronic Publication: 2021 Mar 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenosine A2 Receptor Agonists/*metabolism
Aminopyridines/*metabolism
Pyrimidines/*metabolism
Receptor, Adenosine A2A/*metabolism
Aminopyridines/chemical synthesis ; Animals ; Binding Sites ; CHO Cells ; Cricetulus ; Crystallography, X-Ray ; Drug Inverse Agonism ; Drug Partial Agonism ; HEK293 Cells ; Humans ; Ligands ; Molecular Docking Simulation ; Protein Binding ; Pyrimidines/chemical synthesis ; Small Molecule Libraries/metabolism
Czasopismo naukowe

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