- Tytuł:
- Safety and efficacy of post-haematopoietic cell transplantation maintenance therapy with blinatumomab for relapsed/refractory CD19-positive B-cell acute lymphoblastic leukaemia: protocol for a phase I-II, multicentre, non-blinded, non-controlled trial (JPLSG SCT-ALL-BLIN21).
- Autorzy:
- Corporate Authors:
- Transplantation and Cellular Therapy Committee of Japanese Childhood Cancer Group
- Źródło:
- BMJ open [BMJ Open] 2023 Apr 17; Vol. 13 (4), pp. e070051. Date of Electronic Publication: 2023 Apr 17.
- Typ publikacji:
-
Clinical Trial Protocol; Journal Article; Research Support, Non-U.S. Gov't - MeSH Terms:
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Antibodies, Bispecific*/adverse effects
Antibodies, Bispecific*/therapeutic use
Antigens, CD19*/metabolismClinical Trials as Topic*
Hematopoietic Stem Cell Transplantation*
Maintenance Chemotherapy*/adverse effects
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma*/diagnosis
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma*/drug therapy
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma*/prevention & control
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma*/therapy
Recurrence*
Adolescent ; Child ; Humans ; Young Adult ; Biomarkers, Tumor ; CD3 Complex/metabolism ;Clinical Trials , Phase I as Topic ;Clinical Trials , Phase II as Topic ; Disease-Free Survival ; Drug Resistance, Neoplasm/drug effects ; Graft vs Host Disease/prevention & control ; Japan ; Microbiota ; Multicenter Studies as Topic ; Neoplasm, Residual/prevention & control ; Patient Selection ; Time Factors ; Treatment Outcome ; Sample Size