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Wyszukujesz frazę ""CLINICAL trials"" wg kryterium: Temat


Starter badań:

Tytuł:
Safety and efficacy of post-haematopoietic cell transplantation maintenance therapy with blinatumomab for relapsed/refractory CD19-positive B-cell acute lymphoblastic leukaemia: protocol for a phase I-II, multicentre, non-blinded, non-controlled trial (JPLSG SCT-ALL-BLIN21).
Autorzy:
Sakaguchi H; Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan .
Umeda K; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kato I; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Sakaguchi K; Department of Pediatrics, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Hiramatsu H; Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Ishida H; Department of Pediatrics, Kyoto City Hospital, Kyoto, Japan.
Yabe H; Department of Innovative Medical Science, Tokai University School of Medicine, Isehara, Japan.
Goto H; Division of Hematology/Oncology, Kanagawa Children's Medical Center, Yokohama, Japan.
Kawahara Y; Department of Pediatrics, Jichi Medical University School of Medicine, Tochigi, Japan.
Yamashita YI; Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
Sanada M; Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
Deguchi T; Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan.
Takahashi Y; Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Saito A; Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
Noma H; Department of Data Science, The Institute of Statistical Mathematics, Tokyo, Japan.
Horibe K; Clinical Research Center, National Hospital Organization Nagoya Medical Center, Nagoya, Japan.
Taga T; Department of Pediatrics, Shiga University of Medical Science, Otsu, Japan.
Adachi S; Human Health Science, Kyoto University, Kyoto, Japan.
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Corporate Authors:
Transplantation and Cellular Therapy Committee of Japanese Childhood Cancer Group
Źródło:
BMJ open [BMJ Open] 2023 Apr 17; Vol. 13 (4), pp. e070051. Date of Electronic Publication: 2023 Apr 17.
Typ publikacji:
Clinical Trial Protocol; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antibodies, Bispecific*/adverse effects
Antibodies, Bispecific*/therapeutic use
Antigens, CD19*/metabolism
Clinical Trials as Topic*
Hematopoietic Stem Cell Transplantation*
Maintenance Chemotherapy*/adverse effects
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma*/diagnosis
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma*/drug therapy
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma*/prevention & control
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma*/therapy
Recurrence*
Adolescent ; Child ; Humans ; Young Adult ; Biomarkers, Tumor ; CD3 Complex/metabolism ; Clinical Trials, Phase I as Topic ; Clinical Trials, Phase II as Topic ; Disease-Free Survival ; Drug Resistance, Neoplasm/drug effects ; Graft vs Host Disease/prevention & control ; Japan ; Microbiota ; Multicenter Studies as Topic ; Neoplasm, Residual/prevention & control ; Patient Selection ; Time Factors ; Treatment Outcome ; Sample Size
Czasopismo naukowe
Tytuł:
Clinical trials: Japan's opt-out policy raises risks of adverse drug responses.
Autorzy:
Namba M
Kaneda Y
Ozaki A
Tanimoto T
Pokaż więcej
Źródło:
Nature [Nature] 2024 Feb; Vol. 626 (7998), pp. 261.
Typ publikacji:
Letter
MeSH Terms:
Drug Approval*/legislation & jurisprudence
Drug Approval*/methods
Drug-Related Side Effects and Adverse Reactions*
Health Policy*/legislation & jurisprudence
Clinical Trials as Topic*/legislation & jurisprudence
Clinical Trials as Topic*/methods
Humans ; Japan
Opinia redakcyjna
Tytuł:
Race in clinical trials in Sweden: How regulatory and medical standards in clinical research trump the post-racial discourse.
Autorzy:
Mulinari S; Department of Sociology, Lund University, Lund, Sweden.
Bredström A; Institute for Research on Migration, Ethnicity and Society (REMESO), Linköping University, Norrköping, Sweden.
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Źródło:
Sociology of health & illness [Sociol Health Illn] 2024 Feb; Vol. 46 (2), pp. 315-332. Date of Electronic Publication: 2023 Sep 12.
Typ publikacji:
Review; Journal Article
MeSH Terms:
Ethnicity*
Racial Groups*
Clinical Trials as Topic*
Humans ; Europe ; Sweden
Czasopismo naukowe
Tytuł:
Strategies for enhancing the representation of women in clinical trials: an evidence map.
Autorzy:
Goldstein KM; Center of Innovation to Accelerate Discovery and Practice Transformation, Durham Veterans Affairs Health Care System, 508 Fulton Street, Durham, NC, 27705, USA. .; Division of General Internal Medicine, Duke University School of Medicine, 40 Duke Medicine Circle, Durham, NC, 27710, USA. .
Kung LCY; Health Management & Policy, Graduate School of Public Health, San Diego State University, 5500 Campanile Drive, San Diego, CA, 92182-4162, USA.
Dailey SA; Center of Innovation to Accelerate Discovery and Practice Transformation, Durham Veterans Affairs Health Care System, 508 Fulton Street, Durham, NC, 27705, USA.
Kroll-Desrosiers A; VA Central Western Massachusetts Healthcare System, 421 North Main Street, Leeds, MA, 01053, USA.; UMass Chan Medical School, 55 Lake Ave. N, Worcester, MA, 01655, USA.
Burke C; Department of Population Health Sciences, Duke University School of Medicine, 215 Morris Street, Durham, NC, 27701, USA.
Shepherd-Banigan M; Center of Innovation to Accelerate Discovery and Practice Transformation, Durham Veterans Affairs Health Care System, 508 Fulton Street, Durham, NC, 27705, USA.; Department of Population Health Sciences, Duke University School of Medicine, 215 Morris Street, Durham, NC, 27701, USA.; Duke-Margolis Center for Health Policy, 100 Fuqua Drive, Box 90120, Durham, NC, 27708, USA.
Lumsden R; Division of General Internal Medicine, Duke University School of Medicine, 40 Duke Medicine Circle, Durham, NC, 27710, USA.
Sims C; Center of Innovation to Accelerate Discovery and Practice Transformation, Durham Veterans Affairs Health Care System, 508 Fulton Street, Durham, NC, 27705, USA.; Duke Rheumatology Division, 40 Duke Medicine Circle Clinic 1j, Durham, NC, 27710, USA.
Schexnayder J; University of Alabama at Birmingham School of Nursing, NB545 1720 2nd, Ave S, Birmingham, AL, 35294, USA.
Patel D; Center of Innovation to Accelerate Discovery and Practice Transformation, Durham Veterans Affairs Health Care System, 508 Fulton Street, Durham, NC, 27705, USA.
Cantrell S; Duke University Medical Center Library & Archives, Duke University School of Medicine 10 Searle Drive, Durham, NC, 27710, USA.
Sheahan KL; JSI, 2733 Crystal Drive, Arlington, VA, 22202, USA.
Gierisch JM; Center of Innovation to Accelerate Discovery and Practice Transformation, Durham Veterans Affairs Health Care System, 508 Fulton Street, Durham, NC, 27705, USA.; Division of General Internal Medicine, Duke University School of Medicine, 40 Duke Medicine Circle, Durham, NC, 27710, USA.; Department of Population Health Sciences, Duke University School of Medicine, 215 Morris Street, Durham, NC, 27701, USA.
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Źródło:
Systematic reviews [Syst Rev] 2024 Jan 02; Vol. 13 (1), pp. 2. Date of Electronic Publication: 2024 Jan 02.
Typ publikacji:
Journal Article
MeSH Terms:
Clinical Trials as Topic*
Women*
Patient Selection*
Female ; Humans ; Male ; Gender Identity
Czasopismo naukowe
Tytuł:
Reverse Lasagna's law: the ethics and undesirable consequences of overbooking patients for trials.
Autorzy:
van den Hoek TC; Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands.
Ferrari MD; Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands.
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Źródło:
European journal of neurology [Eur J Neurol] 2023 Dec; Vol. 30 (12), pp. 3633-3634. Date of Electronic Publication: 2023 Sep 19.
Typ publikacji:
Editorial
MeSH Terms:
Clinical Trials as Topic*
Patient Participation*
Humans
Opinia redakcyjna
Tytuł:
The future of the global clinical trial ecosystem: a vision from the first WHO Global Clinical Trials Forum.
Autorzy:
Moorthy V; Science Division, World Health Organization, 1211 Geneva, Switzerland. Electronic address: .
Abubakar I; University College London, London, UK.
Qadri F; icddr,b (International Centre for Diarrhoeal Disease Research), Dhaka, Bangladesh.
Ogutu B; Kenya Medical Research Institute (KEMRI), Nairobi, Kenya.
Zhang W; Science Division, World Health Organization, 1211 Geneva, Switzerland.
Reeder J; Science Division, World Health Organization, 1211 Geneva, Switzerland.
Farrar J; Science Division, World Health Organization, 1211 Geneva, Switzerland.
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Źródło:
Lancet (London, England) [Lancet] 2024 Jan 13; Vol. 403 (10422), pp. 124-126. Date of Electronic Publication: 2023 Dec 18.
Typ publikacji:
Journal Article
MeSH Terms:
Clinical Trials as Topic*
Humans ; World Health Organization
Czasopismo naukowe
Tytuł:
Constructing a finer-grained representation of clinical trial results from ClinicalTrials.gov.
Autorzy:
Shi X; Institute of Medical Technology, Peking University, Beijing, 100191, China.; National Institute of Health Data Science, Peking University, Beijing, 100191, China.
Du J; Institute of Medical Technology, Peking University, Beijing, 100191, China. .; National Institute of Health Data Science, Peking University, Beijing, 100191, China. .
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Źródło:
Scientific data [Sci Data] 2024 Jan 06; Vol. 11 (1), pp. 41. Date of Electronic Publication: 2024 Jan 06.
Typ publikacji:
Dataset; Journal Article
MeSH Terms:
Clinical Trials as Topic*
Humans ; Treatment Outcome
Czasopismo naukowe
Tytuł:
Sponsorship of Clinical Trials Related to the Shoulder and Elbow: Trends Over Time and Comparative Analysis of Trial Characteristics by Sponsorship Type.
Autorzy:
Caruana DL; From the Department of Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, CT.
Grauer JN
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Źródło:
Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews [J Am Acad Orthop Surg Glob Res Rev] 2024 Jan 02; Vol. 8 (1). Date of Electronic Publication: 2024 Jan 02 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Elbow*
Elbow Joint*
Shoulder*
Clinical Trials as Topic*
Government Agencies ; Health Facilities ; Humans
Czasopismo naukowe
Tytuł:
Clinical trials that leverage external data: Do we need more transparent protocols and statistical plans?
Autorzy:
Schwartz DE; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, United States; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, United States. Electronic address: .
Essaouabi H; Northeastern University, Boston, MA, United States.
Trippa L; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, United States; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, United States.
Pokaż więcej
Źródło:
European journal of cancer (Oxford, England : 1990) [Eur J Cancer] 2024 Jan; Vol. 196, pp. 113443. Date of Electronic Publication: 2023 Nov 15.
Typ publikacji:
Letter
MeSH Terms:
Research Design*
Clinical Trials as Topic*
Humans
Opinia redakcyjna
Tytuł:
Creating Equitable and Inclusive Clinical Trials for Multiple Myeloma.
Autorzy:
Hartley-Brown M; Dana-Farber Cancer Institute, Boston, MA.
Cole CE; Michigan State University-Karmanos Cancer Institute, Lansing, MI.
Price P; The Balm in Gilead, Richmond, VA.
Andreini M; Multiple Myeloma Research Foundation, Norwalk, CT.
Mulligan G; Multiple Myeloma Research Foundation, Norwalk, CT.
Young AQ; Multiple Myeloma Research Foundation, Norwalk, CT.
Cho HJ; Multiple Myeloma Research Foundation, Norwalk, CT; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address: .
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Źródło:
Clinical lymphoma, myeloma & leukemia [Clin Lymphoma Myeloma Leuk] 2024 Jan; Vol. 24 (1), pp. 32-39. Date of Electronic Publication: 2023 Sep 15.
Typ publikacji:
Journal Article
MeSH Terms:
Multiple Myeloma*/therapy
Clinical Trials as Topic*
Humans ; Hispanic or Latino ; Black or African American ; Patient Selection
Czasopismo naukowe
Tytuł:
First person profile: Patricia M. LoRusso, DO: This researcher and clinician has conducted work in early-phase trials that has led to the approval of several anticancer agents, all while keeping her focus on the patients she says make these trials possible.
Autorzy:
Nierengarten MB
Pokaż więcej
Źródło:
Cancer [Cancer] 2023 Dec 15; Vol. 129 (24), pp. 3840-3841.
Typ publikacji:
Biography; News
MeSH Terms:
Antineoplastic Agents*/therapeutic use
Clinical Trials as Topic*
Neoplasms*/drug therapy
Humans ; Research Personnel ; Drug Approval
Periodyk
Tytuł:
Evaluation of factors associated with recruitment rates in early phase clinical trials based on the European Clinical Trials Register data.
Autorzy:
Moraga Alapont P; Clinical Pharmacology Department, La Paz University Hospital, IdiPAZ, Madrid, Spain.
Prieto P; Clinical Pharmacology Department, La Paz University Hospital, IdiPAZ, Madrid, Spain.
Urroz M; Pharmacology and Therapeutics Department, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.
Jiménez M; Clinical Pharmacology Department, La Paz University Hospital, IdiPAZ, Madrid, Spain.
Carcas AJ; Clinical Pharmacology Department, La Paz University Hospital, IdiPAZ, Madrid, Spain.; Pharmacology and Therapeutics Department, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.
Borobia AM; Clinical Pharmacology Department, La Paz University Hospital, IdiPAZ, Madrid, Spain.; Pharmacology and Therapeutics Department, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.
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Źródło:
Clinical and translational science [Clin Transl Sci] 2023 Dec; Vol. 16 (12), pp. 2654-2664. Date of Electronic Publication: 2023 Oct 27.
Typ publikacji:
Journal Article
MeSH Terms:
Clinical Trials as Topic*
Patient Selection*
Adult ; Child ; Humans ; Research Design
Czasopismo naukowe
Tytuł:
Race and Ethnicity of Infants Enrolled in Neonatal Clinical Trials: A Systematic Review.
Autorzy:
Lyle ANJ; Department of Pediatrics, University of Washington School of Medicine, Seattle.
Shaikh H; Department of Pediatrics, University of Washington School of Medicine, Seattle.
Oslin E; Treuman Katz Center for Pediatric Bioethics and Palliative Care, Seattle Children's Research Institute, Seattle, Washington.
Gray MM; Department of Pediatrics, University of Washington School of Medicine, Seattle.
Weiss EM; Department of Pediatrics, University of Washington School of Medicine, Seattle.; Treuman Katz Center for Pediatric Bioethics and Palliative Care, Seattle Children's Research Institute, Seattle, Washington.
Pokaż więcej
Źródło:
JAMA network open [JAMA Netw Open] 2023 Dec 01; Vol. 6 (12), pp. e2348882. Date of Electronic Publication: 2023 Dec 01.
Typ publikacji:
Systematic Review; Journal Article
MeSH Terms:
Ethnicity*
Clinical Trials as Topic*
Racial Groups*
Humans ; Infant ; Infant, Newborn
Czasopismo naukowe
Tytuł:
Opportunities and challenges with decentralized trials in Neuroscience.
Autorzy:
Burger HU; Hoffmann-La Roche AG, Basel, Switzerland.
Van de Casteele T; Lundbeck A/S, Copenhagen, Denmark.
Rantell KR; MHRA, London, UK.
Corey-Lisle P; Genentech Inc., South San Francisco, California, USA.
Sfikas N; Novartis AG, Basel, Switzerland.
Abt M; Hoffmann-La Roche AG, Basel, Switzerland.
Pokaż więcej
Corporate Authors:
Working group on Decentralized Trials as part of the European Scientific Interest Group (ESIG) in Neuroscience; Hoffmann-La Roche AG, Basel, Switzerland.
Źródło:
Biometrical journal. Biometrische Zeitschrift [Biom J] 2023 Dec; Vol. 65 (8), pp. e2200370. Date of Electronic Publication: 2023 Aug 23.
Typ publikacji:
Journal Article
MeSH Terms:
Bias*
Clinical Trials as Topic*
Humans
Czasopismo naukowe
Tytuł:
International responses addressing the under-representation of older people in clinical research.
Autorzy:
Markham SC; ARC-Funded Centre of Excellence in Population Ageing Research (CEPAR), Sydney School of Health Sciences, University of Sydney, Sydney, New South Wales, Australia.
McNab J; Discipline of Behavioural and Social Sciences in Health, Sydney School of Health Sciences, University of Sydney, Sydney, New South Wales, Australia.
O'Loughlin K; ARC-Funded Centre of Excellence in Population Ageing Research (CEPAR), Sydney School of Health Sciences, University of Sydney, Sydney, New South Wales, Australia.
Clemson L; ARC-Funded Centre of Excellence in Population Ageing Research (CEPAR), Sydney School of Health Sciences, University of Sydney, Sydney, New South Wales, Australia.
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Źródło:
Australasian journal on ageing [Australas J Ageing] 2023 Dec; Vol. 42 (4), pp. 762-768. Date of Electronic Publication: 2023 Sep 19.
Typ publikacji:
Journal Article
MeSH Terms:
Clinical Trials as Topic*
Patient Selection*
Aged ; Humans
Czasopismo naukowe
Tytuł:
The unblinding of statisticians in clinical trials: commentary on Iflaifel et al., Trials 2023.
Autorzy:
Parker RA; Edinburgh Clinical Trials Unit, Usher Institute, University of Edinburgh, Edinburgh, UK. .
Pokaż więcej
Źródło:
Trials [Trials] 2023 Sep 11; Vol. 24 (1), pp. 579. Date of Electronic Publication: 2023 Sep 11.
Typ publikacji:
Letter
MeSH Terms:
Research Personnel*
Clinical Trials as Topic*
Humans ; Research Design
Opinia redakcyjna
Tytuł:
A rank-based approach to improve the efficiency of inferential seamless phase 2/3 clinical trials with dose optimization.
Autorzy:
Wang X; Bristol Myers Squibb Company, 86 Morris Ave, Summit, NJ 07901, USA.
Chen M; Bristol Myers Squibb Company, 86 Morris Ave, Summit, NJ 07901, USA.
Chu S; Bristol Myers Squibb Company, 86 Morris Ave, Summit, NJ 07901, USA.
Fan R; Pfizer Inc., 500 Arcola Rd, Collegeville, PA 19426, USA. Electronic address: .
Chan ISF; Bristol Myers Squibb Company, 86 Morris Ave, Summit, NJ 07901, USA.
Pokaż więcej
Źródło:
Contemporary clinical trials [Contemp Clin Trials] 2023 Sep; Vol. 132, pp. 107300. Date of Electronic Publication: 2023 Jul 17.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Research Design*
Clinical Trials, Phase II as Topic*
Clinical Trials, Phase III as Topic*
Humans ; Treatment Outcome
Czasopismo naukowe
Tytuł:
Demonstrating Benefit-Risk Profiles of Novel Therapeutic Strategies in Kidney Transplantation: Opportunities and Challenges of Real-World Evidence.
Autorzy:
Helanterä I; Department of Transplantation and Liver Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Snyder J; Hennepin Healthcare Research Institute, Minneapolis, MN, United States.
Åsberg A; Department of Transplantation Medicine, Oslo University Hospital-Rikshospitalet, Oslo, Norway.; Department of Pharmacy, University of Oslo, Oslo, Norway.
Cruzado JM; Department of Nephrology, Bellvitge University Hospital, L'Hospitalet de Llobregat, Barcelona, Spain.; Bellvitge Biomedical Research Institute-IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain.; Clinical Sciences Department, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain.
Bell S; Division of Population Health and Genomics, School of Medicine, University of Dundee, Dundee, United Kingdom.; The Scottish Renal Registry, Scottish Health Audits, Public Health and Intelligence, Information Services, Glasgow, United Kingdom.
Legendre C; Hôpital Necker, Assistance Publique Hôpitaux de Paris (AP-HP) and Université Paris Descartes, Paris, France.
Tedesco-Silva H Jr; Nephrology Division, Hospital do Rim, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, Brazil.
Barcelos GT; Novartis Pharma AG, Basel, Switzerland.
Geissbühler Y; Novartis Pharma AG, Basel, Switzerland.
Prieto L; Novartis Pharma AG, Basel, Switzerland.
Christian JB; IQVIA Real-World Solutions, Durham, NC, United States.
Scalfaro E; IQVIA Real-World Solutions, Basel, Switzerland.
Dreyer NA; IQVIA Real-World Solutions, Cambridge, MA, United States.
Pokaż więcej
Źródło:
Transplant international : official journal of the European Society for Organ Transplantation [Transpl Int] 2022 May 03; Vol. 35, pp. 10329. Date of Electronic Publication: 2022 May 03 (Print Publication: 2022).
Typ publikacji:
Journal Article
MeSH Terms:
Kidney Transplantation*/adverse effects
Pragmatic Clinical Trials as Topic*/standards
Risk Assessment*
Clinical Trials as Topic/standards ; Graft Survival ; Humans ; Research Design/standards
Czasopismo naukowe
Tytuł:
Practical and robust test for comparing binomial proportions in the randomized phase II setting.
Autorzy:
Attwood K; Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.
Park S; Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.; Department of Biostatistics, University at Buffalo, Buffalo, New York, USA.
Hutson AD; Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, New York, USA.
Pokaż więcej
Źródło:
Pharmaceutical statistics [Pharm Stat] 2022 Mar; Vol. 21 (2), pp. 361-371. Date of Electronic Publication: 2021 Oct 09.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Clinical Trials, Phase II as Topic*
Randomized Controlled Trials as Topic*
Research Design*
Clinical Trials, Phase III as Topic ; Humans ; Neoplasms ; Sample Size
Czasopismo naukowe

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