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Tytuł :
Acetylation of PAX7 controls muscle stem cell self-renewal and differentiation potential in mice.
Autorzy :
Sincennes MC; Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Brun CE; Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Lin AYT; Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Rosembert T; Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Datzkiw D; Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Saber J; Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Ming H; Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Kawabe YI; Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Rudnicki MA; Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada. .; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada. .
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Źródło :
Nature communications [Nat Commun] 2021 May 31; Vol. 12 (1), pp. 3253. Date of Electronic Publication: 2021 May 31.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Self Renewal/*genetics
Muscle, Skeletal/*injuries
PAX7 Transcription Factor/*metabolism
Regeneration/*genetics
Satellite Cells, Skeletal Muscle/*physiology
Acetylation ; Animals ; COS Cells ; CRISPR-Cas Systems ; Cardiotoxins/administration & dosage ; Cardiotoxins/toxicity ; Cell Differentiation/genetics ; Chlorocebus aethiops ; Disease Models, Animal ; Gene Knockdown Techniques ; Histone Acetyltransferases/genetics ; Histone Acetyltransferases/metabolism ; Humans ; Mice ; Mice, Transgenic ; Muscle, Skeletal/cytology ; Muscle, Skeletal/drug effects ; Mutagenesis ; Primary Cell Culture ; Promoter Regions, Genetic ; Sf9 Cells ; Sirtuin 2/genetics ; Sirtuin 2/metabolism ; Spodoptera ; Transcriptional Activation
Czasopismo naukowe
Tytuł :
Dynamic remodeling of host membranes by self-organizing bacterial effectors.
Autorzy :
Hsieh TS; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Lopez VA; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Black MH; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Osinski A; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Pawłowski K; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; Department of Biochemistry and Microbiology, Institute of Biology, Warsaw University of Life Sciences, Warsaw 02-776, Poland.
Tomchick DR; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Liou J; Department of Physiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Tagliabracci VS; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. .; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
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Źródło :
Science (New York, N.Y.) [Science] 2021 May 28; Vol. 372 (6545), pp. 935-941. Date of Electronic Publication: 2021 Apr 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacterial Proteins/*metabolism
Endoplasmic Reticulum/*metabolism
Intracellular Membranes/*metabolism
Legionella pneumophila/*physiology
Phosphatidylinositol 3-Kinase/*metabolism
Phosphatidylinositol Phosphates/*metabolism
Animals ; Bacterial Proteins/chemistry ; COS Cells ; Chlorocebus aethiops ; Endoplasmic Reticulum/ultrastructure ; Feedback, Physiological ; HeLa Cells ; Host-Pathogen Interactions ; Humans ; Intracellular Membranes/ultrastructure ; Legionella pneumophila/enzymology ; Legionella pneumophila/genetics ; Legionella pneumophila/growth & development ; Mice ; Mutation ; Phosphatidylinositol 3-Kinase/chemistry ; Phosphatidylinositol Phosphates/chemistry ; Phosphoric Monoester Hydrolases/metabolism ; Protein Domains ; RAW 264.7 Cells
Czasopismo naukowe
Tytuł :
Architecture of the Sema3A/PlexinA4/Neuropilin tripartite complex.
Autorzy :
Lu D; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Shang G; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
He X; Key Laboratory of Molecular Biophysics of the Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China.
Bai XC; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, USA. .; Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA. .
Zhang X; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA. .; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 May 26; Vol. 12 (1), pp. 3172. Date of Electronic Publication: 2021 May 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Nerve Tissue Proteins/*ultrastructure
Neuropilin-1/*ultrastructure
Receptors, Cell Surface/*ultrastructure
Semaphorin-3A/*ultrastructure
Animals ; COS Cells ; Chlorocebus aethiops ; Cryoelectron Microscopy ; HEK293 Cells ; Humans ; Mutation ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/isolation & purification ; Nerve Tissue Proteins/metabolism ; Neuropilin-1/genetics ; Neuropilin-1/isolation & purification ; Neuropilin-1/metabolism ; Protein Binding/genetics ; Protein Domains/genetics ; Protein Multimerization/genetics ; Receptors, Cell Surface/genetics ; Receptors, Cell Surface/isolation & purification ; Receptors, Cell Surface/metabolism ; Recombinant Proteins/genetics ; Recombinant Proteins/isolation & purification ; Recombinant Proteins/metabolism ; Recombinant Proteins/ultrastructure ; Semaphorin-3A/genetics ; Semaphorin-3A/isolation & purification ; Semaphorin-3A/metabolism
Czasopismo naukowe
Tytuł :
In vivo Multi-scale Photoacoustic Imaging Guided Photothermal Therapy of Cervical Cancer based on Customized Laser System and Targeted Nanoparticles.
Autorzy :
Qiu T; The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Department of Biomedical Engineering, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, 511436, People's Republic of China.
Lan Y; The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Department of Biomedical Engineering, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, 511436, People's Republic of China.
Wei Z; The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fujian, 350025, People's Republic of China.
Zhang Y; School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, 511436, Guangdong, People's Republic of China.
Lin Y; The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Department of Biomedical Engineering, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, 511436, People's Republic of China.
Tu C; The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Department of Biomedical Engineering, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, 511436, People's Republic of China.
Mao G; The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Department of Biomedical Engineering, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, 511436, People's Republic of China.
Zhang L; School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, 511436, Guangdong, People's Republic of China.
Yang B; The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Department of Biomedical Engineering, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, 511436, People's Republic of China.
Zhang J; The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Department of Biomedical Engineering, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, 511436, People's Republic of China.
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Źródło :
International journal of nanomedicine [Int J Nanomedicine] 2021 Apr 15; Vol. 16, pp. 2879-2896. Date of Electronic Publication: 2021 Apr 15 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Lasers*
Photothermal Therapy*
Nanoparticles/*chemistry
Photoacoustic Techniques/*methods
Uterine Cervical Neoplasms/*diagnostic imaging
Uterine Cervical Neoplasms/*therapy
Animals ; COS Cells ; Chlorocebus aethiops ; Female ; Folic Acid/chemistry ; HeLa Cells ; Humans ; Mice, Inbred BALB C ; Mice, Nude ; Nanoparticles/administration & dosage ; Nanoparticles/ultrastructure ; Organ Specificity ; Phantoms, Imaging ; Polymers/chemistry
Czasopismo naukowe
Tytuł :
Tackling resistance in chronic myeloid leukemia: Novel cell death modulators with improved efficacy.
Autorzy :
Schoepf AM; Department of Pharmaceutical Chemistry, Institute of Pharmacy, CMBI - Center for Molecular Biosciences Innsbruck, University of Innsbruck, CCB - Centrum for Chemistry and Biomedicine, Innrain 80-82, 6020, Innsbruck, Austria; Division of Cancer Therapeutics, The Institute of Cancer Research, London, SM2 5NG, United Kingdom.
Salcher S; Tyrolean Cancer Research Institute, Innrain 66, 6020, Innsbruck, Austria; Department of Internal Medicine V, Medical University Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria.
Obexer P; Tyrolean Cancer Research Institute, Innrain 66, 6020, Innsbruck, Austria; Department of Pediatrics II, Medical University Innsbruck, Innrain 66, 6020, Innsbruck, Austria.
Gust R; Department of Pharmaceutical Chemistry, Institute of Pharmacy, CMBI - Center for Molecular Biosciences Innsbruck, University of Innsbruck, CCB - Centrum for Chemistry and Biomedicine, Innrain 80-82, 6020, Innsbruck, Austria. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Apr 15; Vol. 216, pp. 113285. Date of Electronic Publication: 2021 Feb 18.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Drug Resistance, Neoplasm/*drug effects
Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*pathology
Nitriles/*chemistry
Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/therapeutic use ; COS Cells ; Cell Line, Tumor ; Chlorocebus aethiops ; Drug Design ; Gene Expression Regulation ; Humans ; Imatinib Mesylate/therapeutic use ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy ; Nitriles/pharmacology ; PPAR gamma/genetics ; PPAR gamma/metabolism ; Phosphorylation/drug effects ; STAT5 Transcription Factor/antagonists & inhibitors ; STAT5 Transcription Factor/genetics ; STAT5 Transcription Factor/metabolism ; Telmisartan/chemistry ; Telmisartan/pharmacology ; Transcriptional Activation/drug effects ; Tumor Suppressor Proteins/antagonists & inhibitors ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism
Czasopismo naukowe
Tytuł :
Synthesis of a Coumarin-Based PPARγ Fluorescence Probe for Competitive Binding Assay.
Autorzy :
Yoshikawa C; Laboratory of Drug Design and Medicinal Chemistry, Showa Pharmaceutical University, 3-3165 Higashi-Tamagawagakuen, Machida, Tokyo 194-8543, Japan.
Ishida H; Laboratory of Drug Design and Medicinal Chemistry, Showa Pharmaceutical University, 3-3165 Higashi-Tamagawagakuen, Machida, Tokyo 194-8543, Japan.
Ohashi N; Laboratory of Drug Design and Medicinal Chemistry, Showa Pharmaceutical University, 3-3165 Higashi-Tamagawagakuen, Machida, Tokyo 194-8543, Japan.
Itoh T; Laboratory of Drug Design and Medicinal Chemistry, Showa Pharmaceutical University, 3-3165 Higashi-Tamagawagakuen, Machida, Tokyo 194-8543, Japan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 14; Vol. 22 (8). Date of Electronic Publication: 2021 Apr 14.
Typ publikacji :
Journal Article
MeSH Terms :
Binding, Competitive*
Biological Assay*
Coumarins/*chemistry
Fluorescent Dyes/*chemical synthesis
PPAR gamma/*metabolism
Animals ; COS Cells ; Chlorocebus aethiops ; Crystallography, X-Ray ; Fluorescent Dyes/chemistry ; Humans ; Hydrogen Bonding ; Inhibitory Concentration 50 ; Ligands ; PPAR gamma/agonists ; Spectrometry, Fluorescence ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
DCTN1 Binds to TDP-43 and Regulates TDP-43 Aggregation.
Autorzy :
Deshimaru M; Department of Neurology, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180, Japan.; Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-0180, Japan.
Kinoshita-Kawada M; Department of Neurology, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180, Japan.
Kubota K; Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-0180, Japan.
Watanabe T; Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-0180, Japan.
Tanaka Y; Research Institute for the Molecular Pathomechanisms of Epilepsy, Fukuoka University, Fukuoka 814-0180, Japan.
Hirano S; National Hospital Organization, Kokura Medical Center, Kitakyushu, Fukuoka 802-8533, Japan.
Ishidate F; Bioanalysis Unit, iCeMS Analysis Center, Institute for Integrated Cell-Material Sciences, Kyoto University Institute for Advanced Study, Kyoto University, Kyoto 606-8501, Japan.
Hiramoto M; Department of Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA.
Ishikawa M; Department of Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan.
Uehara Y; Faculty of Sports and Health Science, Fukuoka University, Fukuoka 814-0180, Japan.
Okano H; Department of Physiology, Keio University School of Medicine, Tokyo 160-8582, Japan.
Hirose S; Research Institute for the Molecular Pathomechanisms of Epilepsy, Fukuoka University, Fukuoka 814-0180, Japan.
Fujioka S; Department of Neurology, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180, Japan.
Iwasaki K; Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka 814-0180, Japan.
Yuasa-Kawada J; Department of Neurology, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180, Japan.
Mishima T; Department of Neurology, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180, Japan.
Tsuboi Y; Department of Neurology, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180, Japan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 13; Vol. 22 (8). Date of Electronic Publication: 2021 Apr 13.
Typ publikacji :
Journal Article
MeSH Terms :
Protein Aggregates*
DNA-Binding Proteins/*metabolism
Dynactin Complex/*metabolism
Amino Acid Sequence ; Animals ; COS Cells ; Cell Line, Tumor ; Chlorocebus aethiops ; Dynactin Complex/chemistry ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Models, Biological ; Mutant Proteins/chemistry ; Mutant Proteins/metabolism ; Neurons/metabolism ; Nuclear Localization Signals/metabolism ; Point Mutation/genetics ; Protein Binding ; Subcellular Fractions/metabolism
Czasopismo naukowe
Tytuł :
Simultaneous readout of multiple FRET pairs using photochromism.
Autorzy :
Roebroek T; Department of Chemistry, KU Leuven, Leuven, Belgium.
Vandenberg W; Department of Chemistry, KU Leuven, Leuven, Belgium.
Sipieter F; Centre National de la Recherche Scientifique, Institut Jacques Monod, Université de Paris, Paris, France.
Hugelier S; Department of Chemistry, KU Leuven, Leuven, Belgium.
Stove C; Department of Bioanalysis, Ghent University, Ghent, Belgium.
Zhang J; Department of Pharmacology, University of California at San Diego, La Jolla, CA, USA.
Dedecker P; Department of Chemistry, KU Leuven, Leuven, Belgium. .
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Źródło :
Nature communications [Nat Commun] 2021 Mar 31; Vol. 12 (1), pp. 2005. Date of Electronic Publication: 2021 Mar 31.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cyclic AMP-Dependent Protein Kinases/*metabolism
Fluorescence Resonance Energy Transfer/*methods
Fluorescent Dyes/*chemistry
Luminescent Proteins/*chemistry
Algorithms ; Animals ; Biosensing Techniques/methods ; COS Cells ; Chlorocebus aethiops ; HEK293 Cells ; HeLa Cells ; Humans ; Luminescent Proteins/genetics ; Luminescent Proteins/metabolism ; Microscopy, Fluorescence/methods ; Time-Lapse Imaging/methods
Czasopismo naukowe
Tytuł :
A modular tool to query and inducibly disrupt biomolecular condensates.
Autorzy :
Hernández-Candia CN; Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, USA.
Pearce S; Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, USA.
Tucker CL; Department of Pharmacology, University of Colorado School of Medicine, Aurora, CO, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Mar 22; Vol. 12 (1), pp. 1809. Date of Electronic Publication: 2021 Mar 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Protein Multimerization*
Green Fluorescent Proteins/*chemistry
High-Throughput Screening Assays/*methods
Proteins/*chemistry
Animals ; COS Cells ; Chlorocebus aethiops ; Fluorescence Resonance Energy Transfer ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; HEK293 Cells ; Humans ; Microscopy, Fluorescence/methods ; Proteins/genetics ; Proteins/metabolism ; RNA-Binding Protein FUS/chemistry ; RNA-Binding Protein FUS/genetics ; RNA-Binding Protein FUS/metabolism
Czasopismo naukowe
Tytuł :
BioAIEgens derived from rosin: how does molecular motion affect their photophysical processes in solid state?
Autorzy :
Cai XM; Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Rescources, College of Chemical Engineering, Nanjing Forestry University, Nanjing, China.; Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Institute of Molecular Functional Materials, Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
Lin Y; Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Rescources, College of Chemical Engineering, Nanjing Forestry University, Nanjing, China.
Li Y; Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Institute of Molecular Functional Materials, Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
Chen X; Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Rescources, College of Chemical Engineering, Nanjing Forestry University, Nanjing, China.
Wang Z; Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Institute of Molecular Functional Materials, Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
Zhao X; Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Institute of Molecular Functional Materials, Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
Huang S; Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Rescources, College of Chemical Engineering, Nanjing Forestry University, Nanjing, China. .
Zhao Z; Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Institute of Molecular Functional Materials, Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China. .; School of Chemistry and Engineering, Southeast University, Nanjing, China. .
Tang BZ; Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Institute of Molecular Functional Materials, Division of Life Science and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China. .
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Źródło :
Nature communications [Nat Commun] 2021 Mar 19; Vol. 12 (1), pp. 1773. Date of Electronic Publication: 2021 Mar 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Luminescence*
Biocompatible Materials/*chemistry
Fluorescent Dyes/*chemistry
Resins, Plant/*chemistry
Animals ; Biocompatible Materials/pharmacology ; COS Cells ; Cell Survival/drug effects ; Chlorocebus aethiops ; Escherichia coli/drug effects ; Fluorescent Dyes/pharmacology ; Microscopy, Confocal ; Molecular Structure ; Motion ; Optical Imaging/methods ; Organelles/chemistry ; Organelles/metabolism ; Resins, Plant/pharmacology ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
siRNAs containing 2'-fluorinated Northern-methanocarbacyclic (2'-F-NMC) nucleotides: in vitro and in vivo RNAi activity and inability of mitochondrial polymerases to incorporate 2'-F-NMC NTPs.
Autorzy :
Akabane-Nakata M; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA.
Erande ND; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA.
Kumar P; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA.
Degaonkar R; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA.
Gilbert JA; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA.
Qin J; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA.
Mendez M; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA.
Woods LB; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA.
Jiang Y; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA.
Janas MM; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA.
O'Flaherty DK; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA.
Zlatev I; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA.
Schlegel MK; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA.
Matsuda S; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA.
Egli M; Department of Biochemistry, School of Medicine, Vanderbilt University, Nashville, TN 37232, USA.
Manoharan M; Alnylam Pharmaceuticals, 675 West Kendall Street, Cambridge, MA 02142, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Mar 18; Vol. 49 (5), pp. 2435-2449.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
RNA Interference*
Nucleotides/*chemistry
RNA, Small Interfering/*chemistry
Animals ; Argonaute Proteins/chemistry ; COS Cells ; Cells, Cultured ; Chlorocebus aethiops ; DNA Polymerase gamma/metabolism ; DNA-Directed RNA Polymerases/metabolism ; Mice ; Mitochondria/enzymology ; Mitochondrial Proteins/metabolism ; Models, Molecular ; Organophosphorus Compounds/chemical synthesis ; Organophosphorus Compounds/chemistry ; Prealbumin/genetics ; Pyrimidine Nucleotides/chemical synthesis ; Pyrimidine Nucleotides/chemistry ; Uridine/analogs & derivatives
Czasopismo naukowe
Tytuł :
Constitutive and Regulated Shedding of Soluble FGF Receptors Releases Biologically Active Inhibitors of FGF-2.
Autorzy :
Hanneken A; Department of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Mercado M; Department of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Maher P; Department of Molecular Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 08; Vol. 22 (5). Date of Electronic Publication: 2021 Mar 08.
Typ publikacji :
Journal Article
MeSH Terms :
Signal Transduction*
Fibroblast Growth Factor 2/*metabolism
Receptor, Fibroblast Growth Factor, Type 1/*metabolism
Animals ; CHO Cells ; COS Cells ; Chlorocebus aethiops ; Cricetulus ; Fibroblast Growth Factor 2/genetics ; Humans ; Protein Kinase C/genetics ; Protein Kinase C/metabolism ; Receptor, Fibroblast Growth Factor, Type 1/genetics ; Solubility
Czasopismo naukowe
Tytuł :
Allele-Specific Knockout by CRISPR/Cas to Treat Autosomal Dominant Retinitis Pigmentosa Caused by the G56R Mutation in NR2E3.
Autorzy :
Diakatou M; INM, University of Montpellier, Inserm, 34091 Montpellier, France.
Dubois G; INM, University of Montpellier, Inserm, 34091 Montpellier, France.
Erkilic N; INM, University of Montpellier, Inserm, 34091 Montpellier, France.; National Reference Centre for Inherited Sensory Diseases, University of Montpellier, CHU, 34295 Montpellier, France.
Sanjurjo-Soriano C; INM, University of Montpellier, Inserm, 34091 Montpellier, France.
Meunier I; INM, University of Montpellier, Inserm, 34091 Montpellier, France.; National Reference Centre for Inherited Sensory Diseases, University of Montpellier, CHU, 34295 Montpellier, France.
Kalatzis V; INM, University of Montpellier, Inserm, 34091 Montpellier, France.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 05; Vol. 22 (5). Date of Electronic Publication: 2021 Mar 05.
Typ publikacji :
Journal Article
MeSH Terms :
Clustered Regularly Interspaced Short Palindromic Repeats/*genetics
Genes, Dominant/*genetics
Mutation/*genetics
Retinitis Pigmentosa/*genetics
Alleles ; Animals ; Base Sequence ; COS Cells ; Cell Line ; Chlorocebus aethiops ; Gene Editing/methods ; HEK293 Cells ; Humans ; Induced Pluripotent Stem Cells/physiology ; Orphan Nuclear Receptors/genetics ; Retina/physiology
Czasopismo naukowe
Tytuł :
Targeting a neoantigen derived from a common TP53 mutation.
Autorzy :
Hsiue EH; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.; Lustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Wright KM; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.; Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Bloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21287, USA.
Douglass J; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.; Lustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Hwang MS; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.; Lustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Mog BJ; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.; Lustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Pearlman AH; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.; Lustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Paul S; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.; Lustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
DiNapoli SR; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.; Lustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Konig MF; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.; Lustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Division of Rheumatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA.
Wang Q; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.; Complete Omics, Baltimore, MD 21227, USA.
Schaefer A; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.; Lustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Miller MS; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.; Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Bloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21287, USA.
Skora AD; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
Azurmendi PA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.; Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Bloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21287, USA.
Murphy MB; Cytiva, Marlborough, MA 01752, USA.
Liu Q; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.; Lustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Watson E; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.; Lustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Li Y; Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Pardoll DM; Bloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21287, USA.; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Bettegowda C; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Lustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Department of Neurosurgery, Johns Hopkins University School of Medicine, MD 21205, USA.
Papadopoulos N; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Lustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Bloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21287, USA.; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Kinzler KW; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Lustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Bloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21287, USA.
Vogelstein B; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. .; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.; Lustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Bloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21287, USA.; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Gabelli SB; Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. .; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Zhou S; Ludwig Center, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. .; Lustgarten Pancreatic Cancer Research Laboratory, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.; Bloomberg~Kimmel Institute for Cancer Immunotherapy, Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21287, USA.
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Źródło :
Science (New York, N.Y.) [Science] 2021 Mar 05; Vol. 371 (6533). Date of Electronic Publication: 2021 Mar 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Bispecific/*immunology
Antibodies, Neoplasm/*immunology
Antigens, Neoplasm/*immunology
HLA-A2 Antigen/*immunology
Neoplasms/*therapy
Tumor Suppressor Protein p53/*immunology
Alleles ; Animals ; Antibodies, Bispecific/chemistry ; Antibodies, Bispecific/therapeutic use ; Antibodies, Neoplasm/chemistry ; Antibodies, Neoplasm/therapeutic use ; Arginine/genetics ; COS Cells ; Chlorocebus aethiops ; Female ; HEK293 Cells ; HLA-A2 Antigen/chemistry ; HLA-A2 Antigen/genetics ; Histidine/genetics ; Humans ; Immunization, Passive ; Jurkat Cells ; Lymphocyte Activation ; Mice, Inbred NOD ; Mutation ; T-Lymphocytes/immunology ; Tumor Suppressor Protein p53/chemistry ; Tumor Suppressor Protein p53/genetics ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Neuropathy-causing TRPV4 mutations disrupt TRPV4-RhoA interactions and impair neurite extension.
Autorzy :
McCray BA; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. .
Diehl E; Department of Chemistry, Biochemistry Section, Johannes Gutenberg-Universität Mainz, Mainz, Germany.; Center for Biomolecular Magnetic Resonance (BMRZ), Goethe-Universität, Frankfurt am Main, Germany.
Sullivan JM; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Aisenberg WH; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Zaccor NW; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Lau AR; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Rich DJ; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Goretzki B; Department of Chemistry, Biochemistry Section, Johannes Gutenberg-Universität Mainz, Mainz, Germany.; Center for Biomolecular Magnetic Resonance (BMRZ), Goethe-Universität, Frankfurt am Main, Germany.
Hellmich UA; Department of Chemistry, Biochemistry Section, Johannes Gutenberg-Universität Mainz, Mainz, Germany.; Center for Biomolecular Magnetic Resonance (BMRZ), Goethe-Universität, Frankfurt am Main, Germany.; Institute of Organic Chemistry and Macromolecular Chemistry, Cluster of Excellence 'Balance of the Microverse', Friedrich-Schiller-Universität, Jena, Germany.
Lloyd TE; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sumner CJ; Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. .; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Mar 04; Vol. 12 (1), pp. 1444. Date of Electronic Publication: 2021 Mar 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Neurites/*metabolism
Peripheral Nervous System Diseases/*genetics
TRPV Cation Channels/*genetics
TRPV Cation Channels/*metabolism
rhoA GTP-Binding Protein/*metabolism
Actin Cytoskeleton/metabolism ; Animals ; COS Cells ; Calcium/metabolism ; Cell Line ; Chlorocebus aethiops ; Drosophila ; HEK293 Cells ; Humans
Czasopismo naukowe
Tytuł :
Tethered agonist exposure in intact adhesion/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain.
Autorzy :
Beliu G; Department of Biotechnology and Biophysics, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.
Altrichter S; Rudolf Schönheimer Institute of Biochemistry, Division of General Biochemistry, Medical Faculty, Leipzig University, Johannisallee 30, 04103 Leipzig, Germany.
Guixà-González R; Institute for Medical Physics and Biophysics, Medical Faculty, Leipzig University, Härtelstrasse 16-18, 04107 Leipzig, Germany; Laboratory of Biomolecular Research, Paul Scherrer Institute (PSI), 5232 Villigen PSI, Switzerland; Condensed Matter Theory Group, PSI, 5232 Villigen PSI, Switzerland.
Hemberger M; Rudolf Schönheimer Institute of Biochemistry, Division of General Biochemistry, Medical Faculty, Leipzig University, Johannisallee 30, 04103 Leipzig, Germany.
Brauer I; Rudolf Schönheimer Institute of Biochemistry, Division of General Biochemistry, Medical Faculty, Leipzig University, Johannisallee 30, 04103 Leipzig, Germany.
Dahse AK; Rudolf Schönheimer Institute of Biochemistry, Division of General Biochemistry, Medical Faculty, Leipzig University, Johannisallee 30, 04103 Leipzig, Germany.
Scholz N; Rudolf Schönheimer Institute of Biochemistry, Division of General Biochemistry, Medical Faculty, Leipzig University, Johannisallee 30, 04103 Leipzig, Germany.
Wieduwild R; Rudolf Schönheimer Institute of Biochemistry, Division of General Biochemistry, Medical Faculty, Leipzig University, Johannisallee 30, 04103 Leipzig, Germany.
Kuhlemann A; Department of Biotechnology and Biophysics, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.
Batebi H; Institute for Medical Physics and Biophysics, Medical Faculty, Leipzig University, Härtelstrasse 16-18, 04107 Leipzig, Germany.
Seufert F; Institute for Medical Physics and Biophysics, Medical Faculty, Leipzig University, Härtelstrasse 16-18, 04107 Leipzig, Germany.
Pérez-Hernández G; Institute of Medical Physics and Biophysics, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.
Hildebrand PW; Institute for Medical Physics and Biophysics, Medical Faculty, Leipzig University, Härtelstrasse 16-18, 04107 Leipzig, Germany; Institute of Medical Physics and Biophysics, Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany; Berlin Institute of Health, 10178 Berlin, Germany. Electronic address: .
Sauer M; Department of Biotechnology and Biophysics, Biocenter, University of Würzburg, Am Hubland, 97074 Würzburg, Germany. Electronic address: .
Langenhan T; Rudolf Schönheimer Institute of Biochemistry, Division of General Biochemistry, Medical Faculty, Leipzig University, Johannisallee 30, 04103 Leipzig, Germany. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Mar 04; Vol. 81 (5), pp. 905-921.e5. Date of Electronic Publication: 2021 Jan 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antigens, CD/*chemistry
Nerve Tissue Proteins/*chemistry
Peptides/*chemistry
Receptors, G-Protein-Coupled/*chemistry
Receptors, Peptide/*chemistry
Amino Acid Sequence ; Animals ; Antigens, CD/genetics ; Antigens, CD/metabolism ; Binding Sites ; COS Cells ; Chlorocebus aethiops ; Crystallography, X-Ray ; Gene Expression ; HEK293 Cells ; Humans ; Molecular Dynamics Simulation ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Peptides/genetics ; Peptides/metabolism ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Protein Multimerization ; Proteolysis ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism ; Receptors, Peptide/genetics ; Receptors, Peptide/metabolism ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Sequence Alignment ; Sequence Homology, Amino Acid ; Signal Transduction
Czasopismo naukowe
Tytuł :
Molecular characterization of Thai patients with phenylalanine hydroxylase deficiency and in vitro functional study of two novel PAH variants.
Autorzy :
Ngiwsara L; Laboratory of Biochemistry, Chulabhorn Research Institute, Bangkok, Thailand.
Vatanavicharn N; Division of Medical Genetics, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. .
Sawangareetrakul P; Laboratory of Biochemistry, Chulabhorn Research Institute, Bangkok, Thailand.
Liammongkolkul S; Division of Medical Genetics, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Ratanarak P; Division of Medical Genetics, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Boonyawat B; Department of Pediatrics, Phramongkutklao Hospital, Bangkok, Thailand.
Srisomsap C; Laboratory of Biochemistry, Chulabhorn Research Institute, Bangkok, Thailand.
Champattanachai V; Laboratory of Biochemistry, Chulabhorn Research Institute, Bangkok, Thailand.
Ketudat-Cairns J; Laboratory of Biochemistry, Chulabhorn Research Institute, Bangkok, Thailand.; School of Biochemistry, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima, Thailand.
Wasant P; Division of Medical Genetics, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Svasti J; Laboratory of Biochemistry, Chulabhorn Research Institute, Bangkok, Thailand.
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Źródło :
Molecular biology reports [Mol Biol Rep] 2021 Mar; Vol. 48 (3), pp. 2063-2070. Date of Electronic Publication: 2021 Mar 07.
Typ publikacji :
Journal Article
MeSH Terms :
Genetic Variation*
Phenylalanine Hydroxylase/*genetics
Phenylketonurias/*enzymology
Phenylketonurias/*genetics
Animals ; COS Cells ; Chlorocebus aethiops ; Gene Expression Regulation, Enzymologic ; Humans ; Mutation/genetics ; Phenotype ; Phenylalanine Hydroxylase/chemistry ; Thailand
Czasopismo naukowe
Tytuł :
Ultra-bright Raman dots for multiplexed optical imaging.
Autorzy :
Zhao Z; Department of Chemistry, Columbia University, New York, NY, USA.
Chen C; Department of Chemistry, Columbia University, New York, NY, USA.
Wei S; Department of Chemistry, Columbia University, New York, NY, USA.
Xiong H; Department of Chemistry, Columbia University, New York, NY, USA.
Hu F; Department of Chemistry, Columbia University, New York, NY, USA.
Miao Y; Department of Chemistry, Columbia University, New York, NY, USA.
Jin T; Department of Applied Physics and Applied Mathematics, Columbia University, New York, NY, USA.
Min W; Department of Chemistry, Columbia University, New York, NY, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 26; Vol. 12 (1), pp. 1305. Date of Electronic Publication: 2021 Feb 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Optical Imaging/*methods
Spectrum Analysis, Raman/*methods
Animals ; Biomarkers ; COS Cells ; Chlorocebus aethiops ; Cytoskeleton ; HeLa Cells ; Humans ; Microscopy/methods ; Nanoparticles ; Optical Imaging/instrumentation
Czasopismo naukowe
Tytuł :
An ESCRT-dependent step in fatty acid transfer from lipid droplets to mitochondria through VPS13D-TSG101 interactions.
Autorzy :
Wang J; Department of Biochemistry and Molecular Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Fang N; Department of Biochemistry and Molecular Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Xiong J; Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Du Y; Department of Biochemistry and Molecular Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Cao Y; Department of Biochemistry and Molecular Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Ji WK; Department of Biochemistry and Molecular Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. .
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Źródło :
Nature communications [Nat Commun] 2021 Feb 23; Vol. 12 (1), pp. 1252. Date of Electronic Publication: 2021 Feb 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA-Binding Proteins/*metabolism
Endosomal Sorting Complexes Required for Transport/*metabolism
Fatty Acids/*metabolism
Lipid Droplets/*metabolism
Mitochondria/*metabolism
Proteins/*metabolism
Transcription Factors/*metabolism
Amino Acid Motifs ; Amino Acid Sequence ; Animals ; COS Cells ; Chlorocebus aethiops ; Fluorescence ; HEK293 Cells ; Humans ; Models, Biological ; Mutant Proteins/metabolism ; Protein Domains ; Protein Structure, Secondary ; Proteins/chemistry
Czasopismo naukowe
Tytuł :
Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay.
Autorzy :
Gray AN; Department of Biology and Chemistry, Azusa Pacific University.
Ramirez BM; Department of Biology and Chemistry, Azusa Pacific University.
Mawugbe SK; Department of Biology and Chemistry, Azusa Pacific University.
Mar JF; Department of Biology and Chemistry, Azusa Pacific University.
Wong YC; Department of Biology and Chemistry, Azusa Pacific University.
Huang KS; Department of Biology and Chemistry, Azusa Pacific University; .
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Źródło :
Journal of visualized experiments : JoVE [J Vis Exp] 2021 Feb 09 (168). Date of Electronic Publication: 2021 Feb 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media
MeSH Terms :
Cell Proliferation*
Heterocyclic Compounds/*chemical synthesis
Heterocyclic Compounds/*pharmacology
Solid-Phase Synthesis Techniques/*methods
Spiro Compounds/*chemical synthesis
Spiro Compounds/*pharmacology
Animals ; COS Cells ; Chlorocebus aethiops
Czasopismo naukowe

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