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    Tytuł:
    Reduced secreted clusterin as a mechanism for Alzheimer-associated CLU mutations.
    Autorzy:
    Bettens K; VIB Department of Molecular Genetics, University of Antwerp - CDE, Building V Universiteitsplein 1, B-2610, Antwerpen, Belgium. .; Institute Born-Bunge, Laboratory of Neurochemistry and Behavior, University of Antwerp, Antwerp, Belgium. .
    Vermeulen S; VIB Department of Molecular Genetics, University of Antwerp - CDE, Building V Universiteitsplein 1, B-2610, Antwerpen, Belgium. .; Institute Born-Bunge, Laboratory of Neurochemistry and Behavior, University of Antwerp, Antwerp, Belgium. .
    Van Cauwenberghe C; VIB Department of Molecular Genetics, University of Antwerp - CDE, Building V Universiteitsplein 1, B-2610, Antwerpen, Belgium. .; Institute Born-Bunge, Laboratory of Neurochemistry and Behavior, University of Antwerp, Antwerp, Belgium. .
    Heeman B; VIB Department of Molecular Genetics, University of Antwerp - CDE, Building V Universiteitsplein 1, B-2610, Antwerpen, Belgium. .; Institute Born-Bunge, Laboratory of Neurochemistry and Behavior, University of Antwerp, Antwerp, Belgium. .
    Asselbergh B; VIB Department of Molecular Genetics, University of Antwerp - CDE, Building V Universiteitsplein 1, B-2610, Antwerpen, Belgium. .; Institute Born-Bunge, Laboratory of Neurochemistry and Behavior, University of Antwerp, Antwerp, Belgium. .
    Robberecht C; VIB Department of Molecular Genetics, University of Antwerp - CDE, Building V Universiteitsplein 1, B-2610, Antwerpen, Belgium. .; Institute Born-Bunge, Laboratory of Neurochemistry and Behavior, University of Antwerp, Antwerp, Belgium. .
    Engelborghs S; Institute Born-Bunge, Laboratory of Neurochemistry and Behavior, University of Antwerp, Antwerp, Belgium. .; Department of Neurology and Memory Clinic, Hospital Network Antwerp Middelheim and Hoge Beuken, Antwerp, Belgium. .
    Vandenbulcke M; Department of Psychiatry and Memory Clinic, University of Leuven and University Hospitals Leuven Gasthuisberg, Leuven, Belgium. .
    Vandenberghe R; Laboratory for Cognitive Neurology, Department of Neurology, University of Leuven and University Hospitals Leuven Gasthuisberg, Leuven, Belgium. .
    De Deyn PP; Institute Born-Bunge, Laboratory of Neurochemistry and Behavior, University of Antwerp, Antwerp, Belgium. .; Department of Neurology and Memory Clinic, Hospital Network Antwerp Middelheim and Hoge Beuken, Antwerp, Belgium. .; Department of Neurology and Alzheimer Research Center, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands. .
    Cruts M; VIB Department of Molecular Genetics, University of Antwerp - CDE, Building V Universiteitsplein 1, B-2610, Antwerpen, Belgium. marc.cruts@molgen.vib-ua.be.; Institute Born-Bunge, Laboratory of Neurochemistry and Behavior, University of Antwerp, Antwerp, Belgium. marc.cruts@molgen.vib-ua.be.
    Van Broeckhoven C; VIB Department of Molecular Genetics, University of Antwerp - CDE, Building V Universiteitsplein 1, B-2610, Antwerpen, Belgium. .; Institute Born-Bunge, Laboratory of Neurochemistry and Behavior, University of Antwerp, Antwerp, Belgium. .
    Sleegers K; VIB Department of Molecular Genetics, University of Antwerp - CDE, Building V Universiteitsplein 1, B-2610, Antwerpen, Belgium. .; Institute Born-Bunge, Laboratory of Neurochemistry and Behavior, University of Antwerp, Antwerp, Belgium. .
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    Źródło:
    Molecular neurodegeneration [Mol Neurodegener] 2015 Jul 16; Vol. 10, pp. 30. Date of Electronic Publication: 2015 Jul 16.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Mutation, Missense*
    Alzheimer Disease/*genetics
    Clusterin/*metabolism
    Aged ; Aged, 80 and over ; Alzheimer Disease/epidemiology ; Alzheimer Disease/physiopathology ; Amino Acid Substitution ; Belgium/epidemiology ; Biological Transport ; Clusterin/genetics ; Cystine/chemistry ; Dimerization ; Endoplasmic Reticulum/metabolism ; Exons/genetics ; Female ; Frameshift Mutation ; Golgi Apparatus/metabolism ; HEK293 Cells ; HeLa Cells ; Humans ; Male ; Protein Conformation ; Recombinant Fusion Proteins/metabolism ; Transduction, Genetic ; Transfection
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites.
    Autorzy:
    Brouwers N; Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerpen, Belgium.
    Van Cauwenberghe C
    Engelborghs S
    Lambert JC
    Bettens K
    Le Bastard N
    Pasquier F
    Montoya AG
    Peeters K
    Mattheijssens M
    Vandenberghe R
    Deyn PP
    Cruts M
    Amouyel P
    Sleegers K
    Van Broeckhoven C
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    Źródło:
    Molecular psychiatry [Mol Psychiatry] 2012 Feb; Vol. 17 (2), pp. 223-33. Date of Electronic Publication: 2011 Mar 15.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Alzheimer Disease/*genetics
    Complement Factor I/*metabolism
    DNA Copy Number Variations/*genetics
    Polymorphism, Single Nucleotide/*genetics
    Receptors, Complement/*genetics
    Aged ; Aged, 80 and over ; Alzheimer Disease/cerebrospinal fluid ; Amyloid beta-Peptides/cerebrospinal fluid ; Apolipoprotein E4/genetics ; Cohort Studies ; Female ; Gene Frequency ; Genome-Wide Association Study ; Genotype ; Humans ; Logistic Models ; Male ; Meta-Analysis as Topic ; Odds Ratio ; Peptide Fragments/cerebrospinal fluid ; Segmental Duplications, Genomic ; tau Proteins/cerebrospinal fluid
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Contribution of TARDBP to Alzheimer's disease genetic etiology.
    Autorzy:
    Brouwers N; Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerpen, Belgium.
    Bettens K
    Gijselinck I
    Engelborghs S
    Pickut BA
    Van Miegroet H
    Montoya AG
    Mattheijssens M
    Peeters K
    De Deyn PP
    Cruts M
    Sleegers K
    Van Broeckhoven C
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    Źródło:
    Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2010; Vol. 21 (2), pp. 423-30.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Point Mutation*
    Alzheimer Disease/*etiology
    Alzheimer Disease/*genetics
    DNA-Binding Proteins/*genetics
    Adult ; Age of Onset ; Aged ; Aged, 80 and over ; Alzheimer Disease/metabolism ; DNA Mutational Analysis ; DNA-Binding Proteins/metabolism ; Exons/genetics ; Female ; Genetic Variation ; Humans ; Male ; Middle Aged ; Nuclear Localization Signals/genetics ; Nuclear Localization Signals/metabolism ; Polymorphism, Single Nucleotide
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Genetic association of the presenilin-1 regulatory region with early-onset Alzheimer's disease in a population-based sample.
    Autorzy:
    van Duijn CM; Department of Epidemiology & Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands.
    Cruts M
    Theuns J
    Van Gassen G
    Backhovens H
    van den Broeck M
    Wehnert A
    Serneels S
    Hofman A
    Van Broeckhoven C
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    Źródło:
    European journal of human genetics : EJHG [Eur J Hum Genet] 1999 Oct-Nov; Vol. 7 (7), pp. 801-6.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Age of Onset*
    Alzheimer Disease/*genetics
    Membrane Proteins/*genetics
    Polymorphism, Genetic/*genetics
    Promoter Regions, Genetic/*genetics
    Aged ; Case-Control Studies ; Genes, Regulator/genetics ; Humans ; Introns/genetics ; Linkage Disequilibrium ; Middle Aged ; Mutation ; Presenilin-1 ; Tandem Repeat Sequences/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-10 z 10

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