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Wyszukujesz frazę ""CYCLOOXYGENASE 2"" wg kryterium: Temat


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Tytuł :
Arylidene analogues as selective COX-2 inhibitors: synthesis, characterization, in silico and in vitro studies.
Autorzy :
Namera DL; Center of Excellence, NFDD Complex, Department of Chemistry, Saurashtra University, Rajkot, Gujarat, India.
Thakkar SS; P.D. Patel Institute of Applied Sciences, Charotar University of Science and Technology, Changa, Gujarat, India.
Thakor P; P.G. Department of Biosciences, Sardar Patel University, Vallabh Vidyanagar, Gujarat, India.
Bhoya U; Department of Chemistry, Saurashtra University, Rajkot, Gujarat, India.
Shah A; Center of Excellence, NFDD Complex, Department of Chemistry, Saurashtra University, Rajkot, Gujarat, India.
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Źródło :
Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2021 Nov; Vol. 39 (18), pp. 7150-7159. Date of Electronic Publication: 2020 Aug 14.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents, Non-Steroidal*/pharmacology
Cyclooxygenase 2 Inhibitors*/pharmacology
Celecoxib ; Cyclooxygenase 2/metabolism ; Molecular Docking Simulation ; Molecular Structure ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Molecular insights into benzene sulphonamide substituted diarylpyrazoles as cyclooxygenase-2 inhibitor and its structural modifications.
Autorzy :
Priya D; Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRMIST, Kattankulathur, India.
Kathiravan MK; Department of Pharmaceutical Chemistry, SRM College of Pharmacy, SRMIST, Kattankulathur, India.; Dr APJ Abdul Kalam Research Lab, SRM College of Pharmacy, SRMIST, Kattankulathur, India.
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Źródło :
Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2021 Sep; Vol. 39 (14), pp. 5093-5104. Date of Electronic Publication: 2020 Jun 30.
Typ publikacji :
Journal Article
MeSH Terms :
Benzene*
Cyclooxygenase 2 Inhibitors*
Cyclooxygenase 2/metabolism ; Molecular Docking Simulation ; Quantitative Structure-Activity Relationship ; Sulfonamides
Czasopismo naukowe
Tytuł :
Insights into cyclooxygenase-2 inhibition by isolated bioactive compounds 3-caffeoyl-4-dihydrocaffeoyl quinic acid and isorhamnetin 3-O-β-D-glucopyranoside from Salicornia herbacea.
Autorzy :
Bahuguna A; Department of Food Science and Technology, Yeungnam University, Gyeongsan, Gyeongsangbuk-do 38541, South Korea.
Bharadwaj S; Nanotechnology Research and Application Center, Sabanci University, Istanbul 34956, Turkey.
Bajpai VK; Department of Energy and Materials Engineering, Dongguk University, Seoul 04620, South Korea.
Shukla S; TERI-Deakin Nanobiotechnology Centre, The Energy and Resources Institute, Gwal Pahari, Gurugram, Haryana 122003, India.
Won DW; College of Pharmacy, Chungnam National University, Daejeon 34134, South Korea.
Park I; Natural Product Informatics Research Center, Korea Institute of Science and Technology (KIST), Gangneung, Gangwon-do 25451, South Korea.
Na M; College of Pharmacy, Chungnam National University, Daejeon 34134, South Korea. Electronic address: .
Sonwal S; Department of Biological Engineering, Biohybrid Systems Research Center (BSRC), Inha University, Incheon 22212, South Korea.
Huh YS; Department of Biological Engineering, Biohybrid Systems Research Center (BSRC), Inha University, Incheon 22212, South Korea. Electronic address: .
Han YK; Department of Energy and Materials Engineering, Dongguk University, Seoul 04620, South Korea. Electronic address: .
Simal-Gandara J; Department of Analytical Chemistry and Food Science, University of Vigo - Ourense Campus, E-32004 Ourense, Spain.
Xiao J; Department of Analytical Chemistry and Food Science, University of Vigo - Ourense Campus, E-32004 Ourense, Spain; International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang 212013, China. Electronic address: .
Kim M; Department of Food Science and Technology, Yeungnam University, Gyeongsan, Gyeongsangbuk-do 38541, South Korea; Research Institute of Cell Culture, Yeungnam University, Gyeongsan, Gyeongsangbuk-do 38541, South Korea. Electronic address: .
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Źródło :
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2021 Sep; Vol. 90, pp. 153638. Date of Electronic Publication: 2021 Jun 29.
Typ publikacji :
Journal Article
MeSH Terms :
Chenopodiaceae*/chemistry
Cyclooxygenase 2 Inhibitors*/pharmacology
Quinic Acid*/pharmacology
Quercetin/*analogs & derivatives
Animals ; Cyclooxygenase 2/metabolism ; Mice ; Molecular Docking Simulation ; Molecular Structure ; Quercetin/pharmacology ; RAW 264.7 Cells ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Evaluation of the therapeutic efficacy of human bone marrow mesenchymal stem cells with COX-2 silence and TGF-β3 overexpression in rabbits with antigen-induced arthritis.
Autorzy :
He T; Department of Joint Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250021, China; Department of Orthopedics Surgery, Yantai Yuhuangding Hospital Affiliated to Medical College of Qingdao University, Yantai, Shandong, 264400, China.
Sun S; Department of Joint Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250021, China. Electronic address: .
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Źródło :
Experimental cell research [Exp Cell Res] 2022 Jan 01; Vol. 410 (1), pp. 112945. Date of Electronic Publication: 2021 Nov 25.
Typ publikacji :
Journal Article
MeSH Terms :
Arthritis, Rheumatoid/*genetics
Cyclooxygenase 2/*genetics
Inflammation/*genetics
Transforming Growth Factor beta3/*genetics
Animals ; Antigens/pharmacology ; Arthritis, Rheumatoid/etiology ; Arthritis, Rheumatoid/immunology ; Arthritis, Rheumatoid/pathology ; Cell Differentiation/genetics ; Cell Differentiation/immunology ; Chondrocytes/immunology ; Chondrocytes/metabolism ; Cyclooxygenase 2/drug effects ; Cyclooxygenase 2 Inhibitors/pharmacology ; Disease Models, Animal ; Humans ; Immunity/genetics ; Inflammation/etiology ; Inflammation/immunology ; Inflammation/pathology ; Mesenchymal Stem Cell Transplantation ; Mesenchymal Stem Cells ; Rabbits
Czasopismo naukowe
Tytuł :
Utility of novel 2-furanones in synthesis of other heterocyclic compounds having anti-inflammatory activity with dual COX2/LOX inhibition.
Autorzy :
Abd El-Hameed RH; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt.
Mahgoub S; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Helwan University, Cairo, Egypt.
El-Shanbaky HM; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt.
Mohamed MS; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt.
Ali SA; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Helwan University, Cairo, Egypt.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 977-986.
Typ publikacji :
Journal Article
MeSH Terms :
4-Butyrolactone/*analogs & derivatives
Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
Cyclooxygenase 2 Inhibitors/*pharmacology
Heterocyclic Compounds/*pharmacology
Lipoxygenase Inhibitors/*pharmacology
4-Butyrolactone/chemical synthesis ; 4-Butyrolactone/chemistry ; 4-Butyrolactone/pharmacology ; Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Arachidonate 5-Lipoxygenase/metabolism ; Cyclooxygenase 2/metabolism ; Cyclooxygenase 2 Inhibitors/chemical synthesis ; Cyclooxygenase 2 Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Heterocyclic Compounds/chemical synthesis ; Heterocyclic Compounds/chemistry ; Humans ; Lipoxygenase Inhibitors/chemical synthesis ; Lipoxygenase Inhibitors/chemistry ; Molecular Structure ; Structure-Activity Relationship ; Tumor Necrosis Factor-alpha/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
Synthesis and computational studies of novel fused pyrimidinones as a promising scaffold with analgesic, anti-inflammatory and COX inhibitory potential.
Autorzy :
Said MF; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt, Kasr El-Aini Street, Cairo, P.O. Box 11562, Egypt. Electronic address: .
Georgey HH; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt, Kasr El-Aini Street, Cairo, P.O. Box 11562, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Heliopolis University for Sustainable Development, Cairo, 11777, Egypt. Electronic address: .
Mohammed ER; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt, Kasr El-Aini Street, Cairo, P.O. Box 11562, Egypt.
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Nov 15; Vol. 224, pp. 113682. Date of Electronic Publication: 2021 Jul 03.
Typ publikacji :
Journal Article
MeSH Terms :
Analgesics/*chemistry
Anti-Inflammatory Agents/*chemistry
Cyclooxygenase 2/*metabolism
Pyrimidinones/*chemistry
Analgesics/metabolism ; Analgesics/pharmacology ; Animals ; Anti-Inflammatory Agents/metabolism ; Anti-Inflammatory Agents/therapeutic use ; Behavior, Animal/drug effects ; Cyclooxygenase 1/chemistry ; Cyclooxygenase 1/metabolism ; Cyclooxygenase 2/chemistry ; Cyclooxygenase 2 Inhibitors/chemical synthesis ; Cyclooxygenase 2 Inhibitors/metabolism ; Cyclooxygenase 2 Inhibitors/pharmacology ; Disease Models, Animal ; Drug Design ; Edema/chemically induced ; Edema/drug therapy ; Edema/pathology ; Humans ; Male ; Mice ; Pyrimidinones/metabolism ; Pyrimidinones/therapeutic use ; Quantitative Structure-Activity Relationship ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Design, synthesis and mechanistic study of novel diarylpyrazole derivatives as anti-inflammatory agents with reduced cardiovascular side effects.
Autorzy :
Amin NH; Department of Medicinal Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt. Electronic address: .
Hamed MIA; Department of Organic and Medicinal Chemistry, Faculty of Pharmacy, Fayoum University, 63514, Egypt.
Abdel-Fattah MM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62514, Egypt.
Abusabaa AHA; Department of Organic and Medicinal Chemistry, Faculty of Pharmacy, Fayoum University, 63514, Egypt.
El-Saadi MT; Department of Medicinal Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt; Department of Medicinal Chemistry, Faculty of Pharmacy, Sinai University-Kantra Branch, Egypt.
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2021 Nov; Vol. 116, pp. 105394. Date of Electronic Publication: 2021 Sep 30.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
Cyclooxygenase 2 Inhibitors/*pharmacology
Lipoxygenase Inhibitors/*pharmacology
Pyrazoles/*pharmacology
Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Arachidonate 5-Lipoxygenase/metabolism ; Cardiovascular System/drug effects ; Cyclooxygenase 2/metabolism ; Cyclooxygenase 2 Inhibitors/chemical synthesis ; Cyclooxygenase 2 Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Humans ; Lipoxygenase Inhibitors/chemical synthesis ; Lipoxygenase Inhibitors/chemistry ; Molecular Structure ; Pyrazoles/chemical synthesis ; Pyrazoles/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Symmetrical and un-symmetrical curcumin analogues as selective COX-1 and COX-2 inhibitor.
Autorzy :
Mohan M; Department of Biotechnology, Indian Institute of Technology Hyderabad, Kandi, Sangareddy 502285, India.
Hussain MA; Department of Chemistry, Indian Institute of Technology Hyderabad, Kandi, Sangareddy 502285, India.
Khan FA; Department of Chemistry, Indian Institute of Technology Hyderabad, Kandi, Sangareddy 502285, India. Electronic address: .
Anindya R; Department of Biotechnology, Indian Institute of Technology Hyderabad, Kandi, Sangareddy 502285, India. Electronic address: .
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Źródło :
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2021 May 01; Vol. 160, pp. 105743. Date of Electronic Publication: 2021 Feb 01.
Typ publikacji :
Journal Article
MeSH Terms :
Curcumin*/pharmacology
Cyclooxygenase 2 Inhibitors*/pharmacology
Cyclooxygenase 1 ; Cyclooxygenase 2 ; Molecular Docking Simulation
Czasopismo naukowe
Tytuł :
Targeting of the COX-2/PGE2 axis enhances the antitumor activity of T7 peptide in vitro and in vivo .
Autorzy :
Yang J; Department of Hepatobiliary, Pancreas and Spleen Surgery, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
Zhong J; Department of Hepatobiliary Surgery, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.
Zhou M; Department of Vascular Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
Zhou Y; School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan, China.
Xiu P; Department of General Surgery, Shandong Provincial Qianfoshan Hospital, The First Affiliated Hospital of Shandong First Medical University, Jinan, China.
Liu F; Department of General Surgery, Shandong Provincial Qianfoshan Hospital, The First Affiliated Hospital of Shandong First Medical University, Jinan, China.
Wang F; Department of General Surgery, Shandong Provincial Qianfoshan Hospital, The First Affiliated Hospital of Shandong First Medical University, Jinan, China.
Li Z; Department of Hepatobiliary, Pancreas and Spleen Surgery, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
Tang Y; Department of Hepatobiliary, Pancreas and Spleen Surgery, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
Chen Y; Department of Hepatobiliary, Pancreas and Spleen Surgery, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
Yao S; Department of Hepatobiliary, Pancreas and Spleen Surgery, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
Huang T; Department of Hepatobiliary, Pancreas and Spleen Surgery, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
Liu T; Department of Hepatobiliary, Pancreas and Spleen Surgery, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
Dong X; Department of Hepatobiliary, Pancreas and Spleen Surgery, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
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Źródło :
Drug delivery [Drug Deliv] 2021 Dec; Vol. 28 (1), pp. 844-855.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Hepatocellular/*drug therapy
Collagen Type IV/*pharmacology
Cyclooxygenase 2 Inhibitors/*pharmacology
Dinoprostone/*antagonists & inhibitors
Liver Neoplasms/*drug therapy
Meloxicam/*pharmacology
Peptide Fragments/*pharmacology
Animals ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Proliferation ; Cyclooxygenase 2/metabolism ; Drug Combinations ; Endothelial Cells/drug effects ; Humans ; Hypoxia/pathology ; Integrins/drug effects ; Mice ; Neovascularization, Pathologic/drug therapy ; RNA, Small Interfering/metabolism ; Random Allocation ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
A Phase I/II randomized trial of H56:IC31 vaccination and adjunctive cyclooxygenase-2-inhibitor treatment in tuberculosis patients.
Autorzy :
Jenum S; Department of Infectious diseases, Oslo University Hospital, P.O box 4952, Nydalen, N-0424, Oslo, Norway.
Tonby K; Department of Infectious diseases, Oslo University Hospital, P.O box 4952, Nydalen, N-0424, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, P.O box 1171, Blindern, N-0318, Oslo, Norway.
Rueegg CS; Oslo Centre for Biostatistics and Epidemiology, Oslo University Hospital, P.O box 4950, Nydalen, N-0424, Oslo, Norway.
Rühwald M; Center for Vaccine Research, Department of Infectious Disease Immunology, Statens Serum Institut Artillerivej 5, 2300, Copenhagen, Denmark.; Foundation of Innovative New Diagnostics (FIND), the global alliance for diagnostics, Chemin des Mines 9, 1201, Geneva, Switzerland.
Kristiansen MP; Center for Vaccine Research, Vaccine Development, Statens Serum Institut, Artillerivej 5, 2300, Copenhagen, Denmark.
Bang P; Center for Vaccine Research, Vaccine Development, Statens Serum Institut, Artillerivej 5, 2300, Copenhagen, Denmark.
Olsen IC; Department of Research Support for Clinical Trials,, Oslo University Hospital, P.O box 4950, Nydalen, N-0424, Oslo, Norway.
Sellæg K; Department of Infectious diseases, Oslo University Hospital, P.O box 4952, Nydalen, N-0424, Oslo, Norway.
Røstad K; Department of Infectious diseases, Oslo University Hospital, P.O box 4952, Nydalen, N-0424, Oslo, Norway.
Mustafa T; Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, P.O box 7804, N-5020, Bergen, Norway.; Department of Thoracic Medicine, Haukeland University Hospital, P.O box 1400, N-5021, Bergen, Norway.
Taskén K; Institute of Clinical Medicine, University of Oslo, P.O box 1171, Blindern, N-0318, Oslo, Norway.; Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital, Montebello, 0310, Oslo, Norway.
Kvale D; Department of Infectious diseases, Oslo University Hospital, P.O box 4952, Nydalen, N-0424, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, P.O box 1171, Blindern, N-0318, Oslo, Norway.
Mortensen R; Center for Vaccine Research, Department of Infectious Disease Immunology, Statens Serum Institut Artillerivej 5, 2300, Copenhagen, Denmark.
Dyrhol-Riise AM; Department of Infectious diseases, Oslo University Hospital, P.O box 4952, Nydalen, N-0424, Oslo, Norway. .; Institute of Clinical Medicine, University of Oslo, P.O box 1171, Blindern, N-0318, Oslo, Norway. .
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Źródło :
Nature communications [Nat Commun] 2021 Nov 22; Vol. 12 (1), pp. 6774. Date of Electronic Publication: 2021 Nov 22.
Typ publikacji :
Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Vaccination*
Cyclooxygenase 2 Inhibitors/*pharmacology
Tuberculosis/*drug therapy
Tuberculosis/*immunology
Tuberculosis Vaccines/*immunology
Adolescent ; Adult ; Cyclooxygenase 2 ; Etoricoxib ; Female ; Humans ; Male ; Middle Aged ; Tuberculosis/prevention & control ; Young Adult
Czasopismo naukowe
Tytuł :
Enhancing the tumor cell selectivity of a rhodamine-decorated iridium(III) complex by conjugating with indomethacin for COX-2 targeted photodynamic therapy.
Autorzy :
Liu C; College of Chemistry and Pharmaceutical Engineering, Huanghuai University, Zhumadian 463000, China; Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China. Electronic address: .
Xiang J; Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Xiang C; Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Li H; Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2021 Sep; Vol. 114, pp. 105142. Date of Electronic Publication: 2021 Jul 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Photochemotherapy*
Antineoplastic Agents/*pharmacology
Coordination Complexes/*pharmacology
Cyclooxygenase 2 Inhibitors/*pharmacology
Photosensitizing Agents/*pharmacology
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Coordination Complexes/chemical synthesis ; Coordination Complexes/chemistry ; Cyclooxygenase 2/metabolism ; Cyclooxygenase 2 Inhibitors/chemical synthesis ; Cyclooxygenase 2 Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Female ; Humans ; Indomethacin/chemistry ; Indomethacin/pharmacology ; Iridium/chemistry ; Iridium/pharmacology ; MCF-7 Cells ; Mammary Neoplasms, Experimental/drug therapy ; Mammary Neoplasms, Experimental/metabolism ; Mammary Neoplasms, Experimental/pathology ; Mice ; Mice, Nude ; Molecular Structure ; Photosensitizing Agents/chemical synthesis ; Photosensitizing Agents/chemistry ; Rhodamines/chemistry ; Rhodamines/pharmacology ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Sonapatha (Oroxylum indicum) mediates cytotoxicity in cultured HeLa cells by inducing apoptosis and suppressing NF-κB, COX-2, RASSF7 and NRF2.
Autorzy :
Lalrinzuali K; Department of Zoology Mizoram UniversityTanhril, Aizawl 796 004, Mizoram, India. Electronic address: .
Vabeiryureilai M; Department of Zoology Mizoram UniversityTanhril, Aizawl 796 004, Mizoram, India. Electronic address: .
Jagetia GC; Department of Zoology Mizoram UniversityTanhril, Aizawl 796 004, Mizoram, India. Electronic address: .
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2021 Sep; Vol. 114, pp. 105126. Date of Electronic Publication: 2021 Jun 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents, Phytogenic/*pharmacology
Bignoniaceae/*chemistry
Cyclooxygenase 2 Inhibitors/*pharmacology
Plant Extracts/*pharmacology
Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/isolation & purification ; Cell Proliferation/drug effects ; Cyclooxygenase 2/metabolism ; Cyclooxygenase 2 Inhibitors/chemistry ; Cyclooxygenase 2 Inhibitors/isolation & purification ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; HeLa Cells ; Humans ; Molecular Structure ; NF-E2-Related Factor 2/antagonists & inhibitors ; NF-E2-Related Factor 2/metabolism ; NF-kappa B/antagonists & inhibitors ; NF-kappa B/metabolism ; Plant Extracts/chemistry ; Plant Extracts/isolation & purification ; Structure-Activity Relationship ; Transcription Factors/antagonists & inhibitors ; Transcription Factors/metabolism ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Optimization of pyrazole-based compounds with 1,2,4-triazole-3-thiol moiety as selective COX-2 inhibitors cardioprotective drug candidates: Design, synthesis, cyclooxygenase inhibition, anti-inflammatory, ulcerogenicity, cardiovascular evaluation, and molecular modeling studies.
Autorzy :
Abdellatif KRA; Department of Pharmaceutical Organic Chemistry, Beni-Suef University, Beni-Suef 62514, Egypt. Electronic address: .
Abdelall EKA; Department of Pharmaceutical Organic Chemistry, Beni-Suef University, Beni-Suef 62514, Egypt.
Elshemy HAH; Department of Pharmaceutical Organic Chemistry, Beni-Suef University, Beni-Suef 62514, Egypt.
Philoppes JN; Department of Pharmaceutical Organic Chemistry, Beni-Suef University, Beni-Suef 62514, Egypt.
Hassanein EHM; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 7152, Egypt.
Kahk NM; Department of Pharmaceutical Organic Chemistry, Beni-Suef University, Beni-Suef 62514, Egypt.
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Źródło :
Bioorganic chemistry [Bioorg Chem] 2021 Sep; Vol. 114, pp. 105122. Date of Electronic Publication: 2021 Jun 25.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Anti-Inflammatory Agents, Non-Steroidal/*pharmacology
Cardiotonic Agents/*pharmacology
Cyclooxygenase 2 Inhibitors/*pharmacology
Pyrazoles/*pharmacology
Triazoles/*pharmacology
Animals ; Anti-Inflammatory Agents, Non-Steroidal/chemical synthesis ; Anti-Inflammatory Agents, Non-Steroidal/chemistry ; Cardiotonic Agents/chemical synthesis ; Cardiotonic Agents/chemistry ; Carrageenan ; Cyclooxygenase 2/metabolism ; Cyclooxygenase 2 Inhibitors/chemical synthesis ; Cyclooxygenase 2 Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Edema/chemically induced ; Edema/drug therapy ; Inflammation/drug therapy ; Male ; Models, Molecular ; Molecular Structure ; Pyrazoles/chemistry ; Rats ; Rats, Wistar ; Stomach Ulcer/drug therapy ; Structure-Activity Relationship ; Triazoles/chemistry
Czasopismo naukowe
Tytuł :
Identification of novel COX-2 / CYP19A1 axis involved in the mesothelioma pathogenesis opens new therapeutic opportunities.
Autorzy :
Nuvoli B; Preclinical Models and New Therapeutic Agents Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
Antoniani B; Anatomy Pathology Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
Libener R; Department of Integrated Activities Research and Innovation, SS Antonio and Biagio General Hospital, Alessandria, Italy.
Maconi A; Department of Integrated Activities Research and Innovation, SS Antonio and Biagio General Hospital, Alessandria, Italy.
Sacconi A; Clinical Trial Center, Biostatistics and Bioinformatics Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
Carosi M; Anatomy Pathology Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
Galati R; Preclinical Models and New Therapeutic Agents Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy. .
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Źródło :
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2021 Aug 17; Vol. 40 (1), pp. 257. Date of Electronic Publication: 2021 Aug 17.
Typ publikacji :
Journal Article
MeSH Terms :
Biomarkers, Tumor*
Signal Transduction*/drug effects
Aromatase/*metabolism
Cyclooxygenase 2/*metabolism
Mesothelioma, Malignant/*etiology
Mesothelioma, Malignant/*metabolism
Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Aromatase/genetics ; Cell Line, Tumor ; Cells, Cultured ; Cyclooxygenase 2/genetics ; Cyclooxygenase 2 Inhibitors/pharmacology ; Cyclooxygenase 2 Inhibitors/therapeutic use ; Dinoprostone/metabolism ; Disease Management ; Disease Susceptibility ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Immunohistochemistry ; Mesothelioma, Malignant/drug therapy ; Mesothelioma, Malignant/pathology ; Molecular Targeted Therapy ; Proto-Oncogene Proteins c-akt/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
Potent Phenylpyridine and Oxodihydrofuran Inhibitors of Cyclooxygenase-2: Optimization toward a Long Residence Time with Balanced Internal Energetics.
Autorzy :
Tian G
Suarez J
Zhang Z
Connolly P
Ahn K
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Źródło :
Biochemistry [Biochemistry] 2021 Aug 10; Vol. 60 (31), pp. 2407-2418. Date of Electronic Publication: 2021 Jul 22.
Typ publikacji :
Journal Article
MeSH Terms :
Cyclooxygenase 2 Inhibitors/*chemistry
Drug Discovery/*methods
Enzyme Assays/*methods
Furans/*chemistry
Mass Spectrometry/*methods
Pyridines/*chemistry
Celecoxib/chemistry ; Celecoxib/pharmacology ; Cyclooxygenase 2/metabolism ; Cyclooxygenase 2 Inhibitors/pharmacology ; Etoricoxib/chemistry ; Etoricoxib/pharmacology ; Fluorescence ; Furans/pharmacology ; Humans ; Hydrogen/chemistry ; Kinetics ; Models, Theoretical ; Oxygen/chemistry ; Pyrazoles/chemistry ; Pyrazoles/pharmacology ; Pyridines/pharmacology ; Thermodynamics ; Time Factors
Czasopismo naukowe
Tytuł :
Inhibitory effects of curcumin on aldose reductase and cyclooxygenase-2 enzymes.
Autorzy :
Mirzaei M; Biosensor Research Center, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Harismah K; Department of Chemical Engineering, Faculty of Engineering, Universitas Muhammadiyah Surakarta, Surakarta, Indonesia.
Soleimani M; Isfahan Pharmacy Students' Research Committee, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
Mousavi S; Department of Clinical Pharmacy and Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
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Źródło :
Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2021 Oct; Vol. 39 (17), pp. 6424-6430. Date of Electronic Publication: 2020 Jul 31.
Typ publikacji :
Journal Article
MeSH Terms :
Curcumin*/pharmacology
Enzyme Inhibitors*/pharmacology
Aldehyde Reductase/*antagonists & inhibitors
Cyclooxygenase 2 Inhibitors/*pharmacology
Cyclooxygenase 2 ; Diabetes Mellitus ; Humans ; Male ; Molecular Docking Simulation
Czasopismo naukowe
Tytuł :
Anti-inflammatory β-sitosterols from the Asiatic loop-root mangrove Rhizophora mucronata attenuate 5-lipoxygenase and cyclooxygenase-2 enzymes.
Autorzy :
Chakraborty K; Marine Biotechnology Division, Central Marine Fisheries Research Institute, Ernakulam North, P.B. No. 1603, Cochin, Kerala State, India. Electronic address: .
Joy M; Marine Biotechnology Division, Central Marine Fisheries Research Institute, Ernakulam North, P.B. No. 1603, Cochin, Kerala State, India.
Raola VK; Marine Biotechnology Division, Central Marine Fisheries Research Institute, Ernakulam North, P.B. No. 1603, Cochin, Kerala State, India.
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Źródło :
Steroids [Steroids] 2021 Aug; Vol. 172, pp. 108860. Date of Electronic Publication: 2021 May 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-Inflammatory Agents/*pharmacology
Antioxidants/*pharmacology
Cyclooxygenase 2 Inhibitors/*pharmacology
Lipoxygenase Inhibitors/*pharmacology
Plant Extracts/*pharmacology
Rhizophoraceae/*chemistry
Sitosterols/*pharmacology
Arachidonate 5-Lipoxygenase/chemistry ; Cyclooxygenase 2/chemistry ; Plant Roots/chemistry
Czasopismo naukowe
Tytuł :
Natural COX-2 Inhibitors as Promising Anti-inflammatory Agents: An Update.
Autorzy :
Cui J; School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.
Jia J; School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.
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Źródło :
Current medicinal chemistry [Curr Med Chem] 2021; Vol. 28 (18), pp. 3622-3646.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents, Non-Steroidal*/pharmacology
Anti-Inflammatory Agents, Non-Steroidal*/therapeutic use
Cyclooxygenase 2 Inhibitors*/pharmacology
Cyclooxygenase 2 Inhibitors*/therapeutic use
Cyclooxygenase 2 ; Humans ; Inflammation/drug therapy ; Prostaglandins
Czasopismo naukowe
Tytuł :
A hybrid platform featuring nanomagnetic ligand fishing for discovering COX-2 selective inhibitors from aerial part of Saussurea laniceps Hand.-Mazz.
Autorzy :
Chen Q; School of Chinese Medicine, Hong Kong Baptist University, Hong Kong Special Administrative Region, 999077, PR China.
Zhu L; School of Chinese Medicine, Hong Kong Baptist University, Hong Kong Special Administrative Region, 999077, PR China.
Yip KM; School of Chinese Medicine, Hong Kong Baptist University, Hong Kong Special Administrative Region, 999077, PR China.
Tang Y; School of Chinese Medicine, Hong Kong Baptist University, Hong Kong Special Administrative Region, 999077, PR China; HKBU Institute of Research and Continuing Education (IRACE), Shenzhen, 518000, PR China.
Liu Y; School of Chinese Medicine, Hong Kong Baptist University, Hong Kong Special Administrative Region, 999077, PR China; HKBU Institute of Research and Continuing Education (IRACE), Shenzhen, 518000, PR China.
Jiang T; School of Chemistry, Resources and Environment, Leshan Normal University, Leshan, 614004, PR China.
Zhang J; Key Laboratory of Molecular Target & Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences & the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, PR China.
Zhao Z; School of Chinese Medicine, Hong Kong Baptist University, Hong Kong Special Administrative Region, 999077, PR China.
Yi T; School of Chinese Medicine, Hong Kong Baptist University, Hong Kong Special Administrative Region, 999077, PR China; HKBU Institute of Research and Continuing Education (IRACE), Shenzhen, 518000, PR China. Electronic address: .
Chen H; School of Chinese Medicine, Hong Kong Baptist University, Hong Kong Special Administrative Region, 999077, PR China. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2021 May 10; Vol. 271, pp. 113849. Date of Electronic Publication: 2021 Jan 21.
Typ publikacji :
Journal Article
MeSH Terms :
Cyclooxygenase 2 Inhibitors/*chemistry
Cyclooxygenase 2 Inhibitors/*isolation & purification
Drug Discovery/*methods
Drugs, Chinese Herbal/*pharmacology
Magnetic Iron Oxide Nanoparticles/*chemistry
Nanoconjugates/*chemistry
Saussurea/*chemistry
Animals ; Arthritis, Experimental/chemically induced ; Arthritis, Experimental/drug therapy ; Arthritis, Experimental/pathology ; Celecoxib/adverse effects ; Cell Line ; Cyclooxygenase 2/chemistry ; Cyclooxygenase 2/metabolism ; Cyclooxygenase 2 Inhibitors/adverse effects ; Cyclooxygenase 2 Inhibitors/pharmacology ; Drugs, Chinese Herbal/adverse effects ; Drugs, Chinese Herbal/chemistry ; Glucosides/adverse effects ; Glucosides/pharmacology ; Joints/diagnostic imaging ; Joints/pathology ; Ligands ; Molecular Docking Simulation ; Muscle Cells/drug effects ; Osteoarthritis/drug therapy ; Osteoarthritis/etiology ; Phenylpropionates/adverse effects ; Phenylpropionates/pharmacology ; Plant Components, Aerial/chemistry ; Rats, Sprague-Dawley ; Scopoletin/adverse effects ; Scopoletin/pharmacology ; Ventricular Remodeling/drug effects
Czasopismo naukowe
Tytuł :
Silencing COX-2 blocks PDK1/TRAF4-induced AKT activation to inhibit fibrogenesis during skeletal muscle atrophy.
Autorzy :
Chen H; Department of Orthopedics, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Qian Z; Department of Orthopedics, Zhongda Hospital of Southeast University, Nanjing, Jiangsu, China.
Zhang S; Department of Orthopedics, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Tang J; Department of Plastic and Burn Surgery, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Fang L; Department of Critical Care Medicine, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Jiang F; Department of Orthopedics, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Ge D; Department of Orthopedics, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Chang J; Department of Orthopedics, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Cao J; Department of Orthopedics, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Yang L; Department of Orthopedics, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China. Electronic address: .
Cao X; Department of Orthopedics, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. Electronic address: .
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Źródło :
Redox biology [Redox Biol] 2021 Jan; Vol. 38, pp. 101774. Date of Electronic Publication: 2020 Nov 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cyclooxygenase 2 Inhibitors*
Muscular Atrophy*/drug therapy
Proto-Oncogene Proteins c-akt*/metabolism
Pyruvate Dehydrogenase Acetyl-Transferring Kinase*
TNF Receptor-Associated Factor 4*
Muscle, Skeletal/*pathology
Animals ; Celecoxib ; Cyclooxygenase 2/genetics ; Gene Silencing ; Humans ; Mice ; Muscle, Skeletal/metabolism ; Quality of Life ; Signal Transduction ; Transforming Growth Factor beta1/genetics
Czasopismo naukowe

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