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Tytuł :
Corema album spp: Edible wild crowberries with a high content in minerals and organic acids.
Autorzy :
Brito C; GeoBioTec, GeoBioSciences, GeoTechnologies and GeoEngineering, Earth Sciences Department, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal. Electronic address: .
Bertotti T; MARE-IPLeiria, Marine and Environmental Sciences Centre, School of Tourism and Marine Technology, Polytechnic of Leiria, 2520-630 Peniche, Portugal.
Primitivo MJ; GeoBioTec, GeoBioSciences, GeoTechnologies and GeoEngineering, Earth Sciences Department, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal. Electronic address: .
Neves M; MARE-IPLeiria, Marine and Environmental Sciences Centre, School of Tourism and Marine Technology, Polytechnic of Leiria, 2520-630 Peniche, Portugal. Electronic address: .
Pires CL; University of Coimbra, Coimbra Chemistry Centre (CQC), Chemistry Department, 3004-535 Coimbra, Portugal.
Cruz PF; University of Coimbra, Coimbra Chemistry Centre (CQC), Chemistry Department, 3004-535 Coimbra, Portugal. Electronic address: .
Martins PAT; University of Coimbra, Coimbra Chemistry Centre (CQC), Chemistry Department, 3004-535 Coimbra, Portugal.
Rodrigues AC; CiTechCare, Centre for Innovative Care and Health Technology, School of Health Sciences, Polytechnic of Leiria, 2411-901 Leiria, Portugal. Electronic address: .
Moreno MJ; University of Coimbra, Coimbra Chemistry Centre (CQC), Chemistry Department, 3004-535 Coimbra, Portugal. Electronic address: .
Brito RMM; University of Coimbra, Coimbra Chemistry Centre (CQC), Chemistry Department, 3004-535 Coimbra, Portugal. Electronic address: .
Campos MJ; MARE-IPLeiria, Marine and Environmental Sciences Centre, School of Tourism and Marine Technology, Polytechnic of Leiria, 2520-630 Peniche, Portugal. Electronic address: .
Vaz DC; University of Coimbra, Coimbra Chemistry Centre (CQC), Chemistry Department, 3004-535 Coimbra, Portugal; CiTechCare, Centre for Innovative Care and Health Technology, School of Health Sciences, Polytechnic of Leiria, 2411-901 Leiria, Portugal. Electronic address: .
Pessoa MF; GeoBioTec, GeoBioSciences, GeoTechnologies and GeoEngineering, Earth Sciences Department, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal. Electronic address: .
Lidon F; GeoBioTec, GeoBioSciences, GeoTechnologies and GeoEngineering, Earth Sciences Department, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal. Electronic address: .
Reboredo F; GeoBioTec, GeoBioSciences, GeoTechnologies and GeoEngineering, Earth Sciences Department, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal. Electronic address: .
Ribeiro VS; GeoBioTec, GeoBioSciences, GeoTechnologies and GeoEngineering, Earth Sciences Department, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal; CiTechCare, Centre for Innovative Care and Health Technology, School of Health Sciences, Polytechnic of Leiria, 2411-901 Leiria, Portugal. Electronic address: .
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Źródło :
Food chemistry [Food Chem] 2021 May 30; Vol. 345, pp. 128732. Date of Electronic Publication: 2020 Dec 08.
Typ publikacji :
Journal Article
MeSH Terms :
Ericaceae/*chemistry
Hydroxybenzoates/*analysis
Minerals/*analysis
Plants, Edible/*chemistry
Antioxidants/analysis ; Caco-2 Cells ; Fruit/chemistry ; Humans ; Plant Extracts/toxicity ; Plant Leaves/chemistry
Czasopismo naukowe
Tytuł :
Pharmacokinetic Characterization of LW6, a Novel Hypoxia-Inducible Factor-1α (HIF-1α) Inhibitor in Mice.
Autorzy :
Lee JY; Convergence Medical Research Center, Asan Institute for Life Science, Asan Medical Center, Seoul 05505, Korea.
Lee K; Department of Pharmacy, College of Pharmacy, Korea University, Sejong 30019, Korea.
Lee K; BK21 FOUR Team and Integrated Research Institute for Drug Development, College of Pharmacy, Dongguk University-Seoul, Goyang 10326, Korea.
Kang JS; Laboratory Animal Resource Center, KRIBB, Chungbuk 28116, Korea.
Kim MJ; Laboratory Animal Resource Center, KRIBB, Chungbuk 28116, Korea.
Yoo DG; Department of Medical Science, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
Kim JA; Department of Medical Science, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
Shin EJ; Department of Medical Science, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
Oh SJ; Convergence Medical Research Center, Asan Institute for Life Science, Asan Medical Center, Seoul 05505, Korea.; Department of Medical Science, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Apr 12; Vol. 26 (8). Date of Electronic Publication: 2021 Apr 12.
Typ publikacji :
Journal Article
MeSH Terms :
Acetanilides/*pharmacokinetics
Acetanilides/*pharmacology
Adamantane/*analogs & derivatives
Hypoxia-Inducible Factor 1, alpha Subunit/*antagonists & inhibitors
Acetanilides/blood ; Acetanilides/metabolism ; Adamantane/blood ; Adamantane/metabolism ; Adamantane/pharmacokinetics ; Adamantane/pharmacology ; Animals ; Caco-2 Cells ; Cell Membrane Permeability/drug effects ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Injections, Intravenous ; Male ; Metabolome ; Mice, Inbred ICR ; Microsomes, Liver/drug effects ; Microsomes, Liver/metabolism ; Time Factors
Czasopismo naukowe
Tytuł :
Exopolysaccharide from Lactobacillus plantarum HY7714 Protects against Skin Aging through Skin-Gut Axis Communication.
Autorzy :
Lee K; R&BD Center, Korea Yakult Co Ltd., 22, Giheungdanji-ro 24 beon-gil, Giheung-gu, Gyeonggi-do 17086, Korea.
Kim HJ; R&BD Center, Korea Yakult Co Ltd., 22, Giheungdanji-ro 24 beon-gil, Giheung-gu, Gyeonggi-do 17086, Korea.
Kim SA; R&BD Center, Korea Yakult Co Ltd., 22, Giheungdanji-ro 24 beon-gil, Giheung-gu, Gyeonggi-do 17086, Korea.
Park SD; R&BD Center, Korea Yakult Co Ltd., 22, Giheungdanji-ro 24 beon-gil, Giheung-gu, Gyeonggi-do 17086, Korea.
Shim JJ; R&BD Center, Korea Yakult Co Ltd., 22, Giheungdanji-ro 24 beon-gil, Giheung-gu, Gyeonggi-do 17086, Korea.
Lee JL; R&BD Center, Korea Yakult Co Ltd., 22, Giheungdanji-ro 24 beon-gil, Giheung-gu, Gyeonggi-do 17086, Korea.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Mar 16; Vol. 26 (6). Date of Electronic Publication: 2021 Mar 16.
Typ publikacji :
Journal Article
MeSH Terms :
Gastrointestinal Tract/*drug effects
Lactobacillus plantarum/*metabolism
Polysaccharides/*pharmacology
Protective Agents/*pharmacology
Skin/*drug effects
Skin Aging/*drug effects
Caco-2 Cells ; Cell Line, Tumor ; Cells, Cultured ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Gastrointestinal Microbiome ; Gastrointestinal Tract/microbiology ; Humans ; Occludin/metabolism ; Probiotics/metabolism ; Skin/metabolism ; Tight Junctions/drug effects ; Tight Junctions/metabolism
Czasopismo naukowe
Tytuł :
Particulate Matter Decreases Intestinal Barrier-Associated Proteins Levels in 3D Human Intestinal Model.
Autorzy :
Woodby B; Plants for Human Health Institute, Animal Sciences Dept., NC Research Campus Kannapolis, State University, Kannapolis, NC 28081 USA.
Schiavone ML; Plants for Human Health Institute, Animal Sciences Dept., NC Research Campus Kannapolis, State University, Kannapolis, NC 28081 USA.
Pambianchi E; Plants for Human Health Institute, Animal Sciences Dept., NC Research Campus Kannapolis, State University, Kannapolis, NC 28081 USA.
Mastaloudis A; Pharmanex Research, NSE Products, Inc., Provo, UT 84601, USA.
N Hester S; Pharmanex Research, NSE Products, Inc., Provo, UT 84601, USA.
M Wood S; Pharmanex Research, NSE Products, Inc., Provo, UT 84601, USA.
Pecorelli A; Plants for Human Health Institute, Animal Sciences Dept., NC Research Campus Kannapolis, State University, Kannapolis, NC 28081 USA.
Valacchi G; Plants for Human Health Institute, Animal Sciences Dept., NC Research Campus Kannapolis, State University, Kannapolis, NC 28081 USA.; Department of Biomedical and Specialist Surgical Sciences, University of Ferrara, 44121 Ferrara, Italy.
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Źródło :
International journal of environmental research and public health [Int J Environ Res Public Health] 2020 May 06; Vol. 17 (9). Date of Electronic Publication: 2020 May 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Caco-2 Cells*/drug effects
Caco-2 Cells*/physiology
Gastrointestinal Tract/*drug effects
Gastrointestinal Tract/*metabolism
Intestinal Mucosa/*metabolism
Particulate Matter/*pharmacology
Tight Junctions/*metabolism
Animals ; Humans ; Intestines/physiopathology ; Membrane Proteins/metabolism ; Mice ; Oxidation-Reduction ; Particulate Matter/administration & dosage ; Tight Junction Proteins
Czasopismo naukowe
Tytuł :
Chicken foot broth byproduct: A new source for highly effective peptide-calcium chelate.
Autorzy :
Malison A; Technopreneurship and Innovation Management Program, Graduate School Chulalongkorn University, Chamchuri 10 Building M1 Floor, Soi Chula 12, Phayathai Road, Pathumwan, Bangkok 10330, Thailand.
Arpanutud P; School of Liberal Arts, King Mongkut's University of Technology Thonburi, 126 Pracha-Uthit Road, Bangmod Thungkru, Bangkok 10140, Thailand.
Keeratipibul S; Faculty of Science, Chulalongkorn University, 254 Phayathai Road, Pathumwan, Bangkok 10330, Thailand. Electronic address: .
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Źródło :
Food chemistry [Food Chem] 2021 May 30; Vol. 345, pp. 128713. Date of Electronic Publication: 2020 Dec 02.
Typ publikacji :
Journal Article
MeSH Terms :
Chickens*
Calcium/*chemistry
Meat/*analysis
Peptides/*chemistry
Animals ; Caco-2 Cells ; Chromatography, Liquid ; Humans ; Hydrolysis
Czasopismo naukowe
Tytuł :
Comparative sensitivity of proliferative and differentiated intestinal epithelial cells to the food contaminant, deoxynivalenol.
Autorzy :
Luo S; Toxalim (Research Center in Food Toxicology), Université de Toulouse, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France.
Terciolo C; Toxalim (Research Center in Food Toxicology), Université de Toulouse, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France.
Neves M; Toxalim (Research Center in Food Toxicology), Université de Toulouse, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France.
Puel S; Toxalim (Research Center in Food Toxicology), Université de Toulouse, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France.
Naylies C; Toxalim (Research Center in Food Toxicology), Université de Toulouse, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France.
Lippi Y; Toxalim (Research Center in Food Toxicology), Université de Toulouse, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France.
Pinton P; Toxalim (Research Center in Food Toxicology), Université de Toulouse, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France.
Oswald IP; Toxalim (Research Center in Food Toxicology), Université de Toulouse, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France. Electronic address: .
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Źródło :
Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2021 May 15; Vol. 277, pp. 116818. Date of Electronic Publication: 2021 Feb 25.
Typ publikacji :
Journal Article
MeSH Terms :
Trichothecenes*/toxicity
Caco-2 Cells ; Cell Differentiation ; Epithelial Cells ; Humans
Czasopismo naukowe
Tytuł :
Synthesis, characterization, and evaluation of BDDE crosslinked chitosan-TGA hydrogel encapsulated with genistein for vaginal atrophy.
Autorzy :
Yang IH; Department of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, No. 49, Fanglan Rd, Taipei, 10672, Taiwan.
Lin IE; Department of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, No. 49, Fanglan Rd, Taipei, 10672, Taiwan.
Chen TC; Department of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, No. 49, Fanglan Rd, Taipei, 10672, Taiwan.
Chen ZY; Department of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, No. 49, Fanglan Rd, Taipei, 10672, Taiwan.
Kuan CY; Department of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, No. 49, Fanglan Rd, Taipei, 10672, Taiwan; Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, No. 35, Keyan Road, Zhunan, Miaoli County, 35053, Taiwan.
Lin JN; Department of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, No. 49, Fanglan Rd, Taipei, 10672, Taiwan.
Chou YC; Department of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, No. 49, Fanglan Rd, Taipei, 10672, Taiwan.
Lin FH; Department of Biomedical Engineering, College of Medicine and College of Engineering, National Taiwan University, No. 49, Fanglan Rd, Taipei, 10672, Taiwan; Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, No. 35, Keyan Road, Zhunan, Miaoli County, 35053, Taiwan. Electronic address: .
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Źródło :
Carbohydrate polymers [Carbohydr Polym] 2021 May 15; Vol. 260, pp. 117832. Date of Electronic Publication: 2021 Feb 20.
Typ publikacji :
Journal Article
MeSH Terms :
Atrophic Vaginitis/*drug therapy
Chitosan/*chemistry
Genistein/*therapeutic use
Hydrogels/*chemistry
Thioglycolates/*chemistry
Animals ; Atrophic Vaginitis/pathology ; Caco-2 Cells ; Cell Adhesion/drug effects ; Cell Survival/drug effects ; Drug Carriers/chemistry ; Female ; Genistein/chemistry ; Genistein/metabolism ; Genistein/pharmacology ; Humans ; Hydrogels/chemical synthesis ; Hydrogels/pharmacology ; Mice ; Rats ; Rats, Sprague-Dawley ; Vagina/pathology
Czasopismo naukowe
Tytuł :
Mapping and IgE-binding capacity analysis of heat/digested stable epitopes of mud crab allergens.
Autorzy :
Liu M; College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Jimei University, Xiamen, Fujian 361021, China.
Huan F; College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Jimei University, Xiamen, Fujian 361021, China.
Li M; College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Jimei University, Xiamen, Fujian 361021, China.
Han T; College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Jimei University, Xiamen, Fujian 361021, China.
Xia F; College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Jimei University, Xiamen, Fujian 361021, China.
Yang Y; College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Jimei University, Xiamen, Fujian 361021, China.
Liu Q; College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Jimei University, Xiamen, Fujian 361021, China.
Chen G; Women and Children's Hospital Affiliated to Xiamen University, Xiamen, Fujian 361003, China.
Cao M; College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Jimei University, Xiamen, Fujian 361021, China.
Liu G; College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Jimei University, Xiamen, Fujian 361021, China. Electronic address: .
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Źródło :
Food chemistry [Food Chem] 2021 May 15; Vol. 344, pp. 128735. Date of Electronic Publication: 2020 Nov 28.
Typ publikacji :
Journal Article
MeSH Terms :
Digestion*
Epitope Mapping*
Hot Temperature*
Allergens/*immunology
Brachyura/*immunology
Epitopes/*immunology
Immunoglobulin E/*immunology
Animals ; Basophils/immunology ; Brachyura/metabolism ; Caco-2 Cells ; Humans ; Peptide Fragments/immunology ; Peptide Fragments/metabolism ; Seafood/analysis ; Tropomyosin/metabolism
Czasopismo naukowe
Tytuł :
Effects of intense pulsed light and gamma irradiation on Bacillus cereus spores in mesquite pod flour.
Autorzy :
Chen D; Center for Biorefining and Department of Bioproducts and Biosystems Engineering, University of Minnesota, St. Paul, MN, USA; Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN, USA.
Mosher W; Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN, USA.
Wiertzema J; Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN, USA.
Peng P; Center for Biorefining and Department of Bioproducts and Biosystems Engineering, University of Minnesota, St. Paul, MN, USA.
Min M; Center for Biorefining and Department of Bioproducts and Biosystems Engineering, University of Minnesota, St. Paul, MN, USA.
Cheng Y; Center for Biorefining and Department of Bioproducts and Biosystems Engineering, University of Minnesota, St. Paul, MN, USA.
An J; Center for Biorefining and Department of Bioproducts and Biosystems Engineering, University of Minnesota, St. Paul, MN, USA.
Ma Y; Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN, USA.
Fan X; USDA ARS, Eastern Regional Research Center, Wyndmoor, PA, USA.
Niemira BA; USDA ARS, Eastern Regional Research Center, Wyndmoor, PA, USA.
Baumler DJ; Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN, USA.
Chen C; Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN, USA.
Chen P; Center for Biorefining and Department of Bioproducts and Biosystems Engineering, University of Minnesota, St. Paul, MN, USA.
Ruan Chen R; Center for Biorefining and Department of Bioproducts and Biosystems Engineering, University of Minnesota, St. Paul, MN, USA; Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN, USA. Electronic address: .
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Źródło :
Food chemistry [Food Chem] 2021 May 15; Vol. 344, pp. 128675. Date of Electronic Publication: 2020 Nov 19.
Typ publikacji :
Journal Article
MeSH Terms :
Gamma Rays*
Light*
Bacillus cereus/*physiology
Bacillus cereus/*radiation effects
Flour/*microbiology
Prosopis/*chemistry
Spores, Bacterial/*radiation effects
Caco-2 Cells ; Humans ; Spores, Bacterial/physiology
Czasopismo naukowe
Tytuł :
Circular RNA_0074027 participates in cell proliferation, apoptosis and metastasis of colorectal cancer cells through regulation of miR‑525‑3p.
Autorzy :
Xiong G; Department of General Surgery, Dazhou Central Hospital, Dazhou, Sichuan 635000, P.R. China.
Zhang J; Department of General Surgery, Dazhou Central Hospital, Dazhou, Sichuan 635000, P.R. China.
Zhang Y; Department of General Surgery, Dazhou Central Hospital, Dazhou, Sichuan 635000, P.R. China.
Pang X; Department of General Surgery, Dazhou Central Hospital, Dazhou, Sichuan 635000, P.R. China.
Wang B; Department of General Surgery, Dazhou Central Hospital, Dazhou, Sichuan 635000, P.R. China.
Zhang Y; Department of General Surgery, Dazhou Central Hospital, Dazhou, Sichuan 635000, P.R. China.
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Źródło :
Molecular medicine reports [Mol Med Rep] 2021 May; Vol. 23 (5). Date of Electronic Publication: 2021 Mar 24.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Proliferation/*genetics
Colorectal Neoplasms/*genetics
MicroRNAs/*genetics
RNA, Circular/*genetics
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Apoptosis/genetics ; Caco-2 Cells ; Cell Line, Tumor ; Cell Movement/genetics ; Colorectal Neoplasms/pathology ; Epithelial-Mesenchymal Transition/genetics ; Female ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Lymphatic Metastasis ; Male ; Middle Aged ; Wnt Signaling Pathway/genetics ; Young Adult
Czasopismo naukowe
Tytuł :
P-glycoprotein (ABCB1) is involved in vitamin K efflux.
Autorzy :
Margier M; INRAE, INSERM, Aix Marseille Univ, C2VN, Marseille, France. Electronic address: .
Le May C; Université de Nantes, CNRS, INSERM, l'institut du thorax, F-44000 Nantes, France. Electronic address: .
Antoine T; INRAE, INSERM, Aix Marseille Univ, C2VN, Marseille, France. Electronic address: .
Halimi C; INRAE, INSERM, Aix Marseille Univ, C2VN, Marseille, France. Electronic address: .
Nowicki M; INRAE, INSERM, Aix Marseille Univ, C2VN, Marseille, France. Electronic address: .
Lespine A; INTHERES, Université de Toulouse, INRAE, ENVT, Toulouse, France. Electronic address: .
Reboul E; INRAE, INSERM, Aix Marseille Univ, C2VN, Marseille, France. Electronic address: .
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Źródło :
Food chemistry [Food Chem] 2021 May 01; Vol. 343, pp. 128510. Date of Electronic Publication: 2020 Nov 01.
Typ publikacji :
Journal Article
MeSH Terms :
ATP Binding Cassette Transporter, Subfamily B, Member 1/*metabolism
Vitamin K/*pharmacokinetics
ATP Binding Cassette Transporter, Subfamily B, Member 1/genetics ; Animals ; Caco-2 Cells ; Enterocytes/drug effects ; Enterocytes/metabolism ; Female ; Humans ; Male ; Mice, Mutant Strains ; Postprandial Period ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism
Czasopismo naukowe
Tytuł :
Cytotoxicity study of bakery product melanoidins on intestinal and endothelial cell lines.
Autorzy :
Diaz-Morales N; Department of Biotechnology and Food Science, Faculty of Sciences, University of Burgos, Plaza Misael Bañuelos, 09001 Burgos, Spain. Electronic address: .
Cavia-Saiz M; Department of Biotechnology and Food Science, Faculty of Sciences, University of Burgos, Plaza Misael Bañuelos, 09001 Burgos, Spain. Electronic address: .
Salazar G; Department of Biotechnology and Food Science, Faculty of Sciences, University of Burgos, Plaza Misael Bañuelos, 09001 Burgos, Spain. Electronic address: .
Rivero-Pérez MD; Department of Biotechnology and Food Science, Faculty of Sciences, University of Burgos, Plaza Misael Bañuelos, 09001 Burgos, Spain. Electronic address: .
Muñiz P; Department of Biotechnology and Food Science, Faculty of Sciences, University of Burgos, Plaza Misael Bañuelos, 09001 Burgos, Spain. Electronic address: .
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Źródło :
Food chemistry [Food Chem] 2021 May 01; Vol. 343, pp. 128405. Date of Electronic Publication: 2020 Oct 15.
Typ publikacji :
Journal Article
MeSH Terms :
Bread*
Antioxidants/*pharmacology
Polymers/*pharmacology
Antioxidants/chemistry ; Biological Availability ; Caco-2 Cells ; Cell Survival/drug effects ; Digestion ; Human Umbilical Vein Endothelial Cells ; Humans ; Polymers/isolation & purification ; Polymers/pharmacokinetics
Czasopismo naukowe
Tytuł :
High-throughput screening of the ReFRAME, Pandemic Box, and COVID Box drug repurposing libraries against SARS-CoV-2 nsp15 endoribonuclease to identify small-molecule inhibitors of viral activity.
Autorzy :
Choi R; Division of Allergy and Infectious Diseases, Department of Medicine, Center for Emerging and Reemerging Infectious Diseases (CERID), University of Washington School of Medicine, Seattle, WA, United States of America.
Zhou M; Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory (PNNL), Richland, WA, United States of America.
Shek R; Division of Allergy and Infectious Diseases, Department of Medicine, Center for Emerging and Reemerging Infectious Diseases (CERID), University of Washington School of Medicine, Seattle, WA, United States of America.; Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, WA, United States of America.
Wilson JW; Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory (PNNL), Richland, WA, United States of America.
Tillery L; Division of Allergy and Infectious Diseases, Department of Medicine, Center for Emerging and Reemerging Infectious Diseases (CERID), University of Washington School of Medicine, Seattle, WA, United States of America.; Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, WA, United States of America.
Craig JK; Division of Allergy and Infectious Diseases, Department of Medicine, Center for Emerging and Reemerging Infectious Diseases (CERID), University of Washington School of Medicine, Seattle, WA, United States of America.; Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, WA, United States of America.
Salukhe IA; Department of Microbiology, University of Washington School of Medicine, Seattle, WA, United States of America.
Hickson SE; Department of Microbiology, University of Washington School of Medicine, Seattle, WA, United States of America.
Kumar N; Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory (PNNL), Richland, WA, United States of America.
James RM; Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory (PNNL), Richland, WA, United States of America.
Buchko GW; Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory (PNNL), Richland, WA, United States of America.; Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, WA, United States of America.; School of Molecular Bioscience, Washington State University, Pullman, WA, United States of America.
Wu R; Bioenergy and Biome Sciences, Los Alamos National Laboratory (LANL), Los Alamos, NM, United States of America.
Huff S; Division of Allergy and Infectious Diseases, Department of Medicine, Center for Emerging and Reemerging Infectious Diseases (CERID), University of Washington School of Medicine, Seattle, WA, United States of America.
Nguyen TT; Calibr, a division of The Scripps Research Institute, La Jolla, CA, United States of America.
Hurst BL; Institute for Antiviral Research, Utah State University, Logan, UT, United States of America.
Cherry S; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, United States of America.
Barrett LK; Division of Allergy and Infectious Diseases, Department of Medicine, Center for Emerging and Reemerging Infectious Diseases (CERID), University of Washington School of Medicine, Seattle, WA, United States of America.; Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, WA, United States of America.
Hyde JL; Department of Microbiology, University of Washington School of Medicine, Seattle, WA, United States of America.
Van Voorhis WC; Division of Allergy and Infectious Diseases, Department of Medicine, Center for Emerging and Reemerging Infectious Diseases (CERID), University of Washington School of Medicine, Seattle, WA, United States of America.; Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, WA, United States of America.; Department of Microbiology, University of Washington School of Medicine, Seattle, WA, United States of America.; Department of Global Health, University of Washington, Seattle, WA, United States of America.
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Źródło :
PloS one [PLoS One] 2021 Apr 22; Vol. 16 (4), pp. e0250019. Date of Electronic Publication: 2021 Apr 22 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Drug Repositioning*/methods
Antiviral Agents/*pharmacology
COVID-19/*drug therapy
Endoribonucleases/*antagonists & inhibitors
SARS-CoV-2/*drug effects
Small Molecule Libraries/*pharmacology
Viral Nonstructural Proteins/*antagonists & inhibitors
Animals ; Antiviral Agents/chemistry ; COVID-19/virology ; Caco-2 Cells ; Chlorocebus aethiops ; Endoribonucleases/metabolism ; High-Throughput Screening Assays/methods ; Humans ; Molecular Docking Simulation ; SARS-CoV-2/metabolism ; Small Molecule Libraries/chemistry ; Vero Cells ; Viral Nonstructural Proteins/metabolism
Czasopismo naukowe
Tytuł :
Prodrugs of a 1'-CN-4-Aza-7,9-dideazaadenosine C -Nucleoside Leading to the Discovery of Remdesivir (GS-5734) as a Potent Inhibitor of Respiratory Syncytial Virus with Efficacy in the African Green Monkey Model of RSV.
Autorzy :
Mackman RL; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Hui HC; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Perron M; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Murakami E; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Palmiotti C; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Lee G; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Stray K; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Zhang L; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Goyal B; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Chun K; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Byun D; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Siegel D; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Simonovich S; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Du Pont V; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Pitts J; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Babusis D; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Vijjapurapu A; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Lu X; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Kim C; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Zhao X; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Chan J; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Ma B; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Lye D; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Vandersteen A; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Wortman S; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Barrett KT; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Toteva M; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Jordan R; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Subramanian R; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Bilello JP; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
Cihlar T; Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Apr 22; Vol. 64 (8), pp. 5001-5017. Date of Electronic Publication: 2021 Apr 09.
Typ publikacji :
Journal Article
MeSH Terms :
Adenosine Monophosphate/*analogs & derivatives
Alanine/*analogs & derivatives
Antiviral Agents/*pharmacology
Prodrugs/*pharmacology
Respiratory Syncytial Virus Infections/*drug therapy
Respiratory Syncytial Virus, Human/*drug effects
Adenosine Monophosphate/pharmacology ; Alanine/pharmacology ; Animals ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacokinetics ; Caco-2 Cells ; Cells, Cultured ; Chlorocebus aethiops ; Disease Models, Animal ; Dogs ; Drug Evaluation, Preclinical/methods ; Epithelial Cells/virology ; Humans ; Macaca fascicularis ; Male ; Prodrugs/chemistry ; Prodrugs/pharmacokinetics ; Rats, Sprague-Dawley ; Respiratory Syncytial Virus Infections/virology ; Structure-Activity Relationship ; Tissue Distribution ; Tubercidin/analogs & derivatives ; Tubercidin/chemistry ; Viral Load
Czasopismo naukowe
Tytuł :
Hypoxic and pharmacological activation of HIF inhibits SARS-CoV-2 infection of lung epithelial cells.
Autorzy :
Wing PAC; Nuffield Department of Medicine, University of Oxford, Oxford, UK; Chinese Academy of Medical Sciences (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.
Keeley TP; Nuffield Department of Medicine, University of Oxford, Oxford, UK; Ludwig Institute for Cancer Research, University of Oxford, Oxford, UK.
Zhuang X; Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Lee JY; Department of Biochemistry, University of Oxford, Oxford, UK.
Prange-Barczynska M; Nuffield Department of Medicine, University of Oxford, Oxford, UK; Ludwig Institute for Cancer Research, University of Oxford, Oxford, UK.
Tsukuda S; Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Morgan SB; Respiratory Medicine Unit and National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), Nuffield Department of Medicine, Experimental Medicine, University of Oxford, Oxford, UK.
Harding AC; Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.
Argles ILA; Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Kurlekar S; Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Noerenberg M; Department of Biochemistry, University of Oxford, Oxford, UK; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.
Thompson CP; Peter Medawar Building for Pathogen Research, Department of Zoology, University of Oxford, Oxford, UK.
Huang KA; Research Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Balfe P; Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Watashi K; Department of Virology II, National Institute of Infectious Diseases, Tokyo 162-8640, Japan; Department of Applied Biological Science, Tokyo University of Science, Noda 278-8510, Japan.
Castello A; Department of Biochemistry, University of Oxford, Oxford, UK; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.
Hinks TSC; Respiratory Medicine Unit and National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), Nuffield Department of Medicine, Experimental Medicine, University of Oxford, Oxford, UK.
James W; Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.
Ratcliffe PJ; Nuffield Department of Medicine, University of Oxford, Oxford, UK; Ludwig Institute for Cancer Research, University of Oxford, Oxford, UK; Francis Crick Institute, London, UK.
Davis I; Department of Biochemistry, University of Oxford, Oxford, UK.
Hodson EJ; Francis Crick Institute, London, UK; Department of Experimental Medicine and Immunotherapeutics, University of Cambridge, Cambridge, UK.
Bishop T; Nuffield Department of Medicine, University of Oxford, Oxford, UK; Ludwig Institute for Cancer Research, University of Oxford, Oxford, UK.
McKeating JA; Nuffield Department of Medicine, University of Oxford, Oxford, UK; Chinese Academy of Medical Sciences (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK. Electronic address: .
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Źródło :
Cell reports [Cell Rep] 2021 Apr 20; Vol. 35 (3), pp. 109020. Date of Electronic Publication: 2021 Apr 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
COVID-19/*metabolism
Epithelial Cells/*metabolism
Glycine/*analogs & derivatives
Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism
Isoquinolines/*pharmacology
Lung/*metabolism
SARS-CoV-2/*physiology
Virus Internalization/*drug effects
Virus Replication/*drug effects
A549 Cells ; Animals ; COVID-19/drug therapy ; COVID-19/pathology ; Caco-2 Cells ; Cell Hypoxia/drug effects ; Chlorocebus aethiops ; Epithelial Cells/virology ; Glycine/pharmacology ; Humans ; Lung/virology ; Mice ; Vero Cells
Czasopismo naukowe
Tytuł :
Valorisation of kitul, an overlooked food plant: Phenolic profiling of fruits and inflorescences and assessment of their effects on diabetes-related targets.
Autorzy :
Ferreres F; Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS (CSIC), P.O. Box 164, 30100 Campus University Espinardo, Murcia, Spain. Electronic address: .
Andrade C; REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, R. Jorge Viterbo Ferreira, n° 228, 4050-313 Porto, Portugal. Electronic address: .
Gomes NGM; REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, R. Jorge Viterbo Ferreira, n° 228, 4050-313 Porto, Portugal. Electronic address: .
Andrade PB; REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, R. Jorge Viterbo Ferreira, n° 228, 4050-313 Porto, Portugal. Electronic address: .
Gil-Izquierdo A; Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology, CEBAS (CSIC), P.O. Box 164, 30100 Campus University Espinardo, Murcia, Spain. Electronic address: .
Pereira DM; REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, R. Jorge Viterbo Ferreira, n° 228, 4050-313 Porto, Portugal. Electronic address: .
Suksungworn R; Department of Botany, Faculty of Science, Kasetsart University, Ngam Wong Wan Road, Chatuchak, Bangkok 10900, Thailand. Electronic address: .
Duangsrisai S; Department of Botany, Faculty of Science, Kasetsart University, Ngam Wong Wan Road, Chatuchak, Bangkok 10900, Thailand. Electronic address: .
Videira RA; REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, R. Jorge Viterbo Ferreira, n° 228, 4050-313 Porto, Portugal. Electronic address: .
Valentão P; REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, R. Jorge Viterbo Ferreira, n° 228, 4050-313 Porto, Portugal. Electronic address: .
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Źródło :
Food chemistry [Food Chem] 2021 Apr 16; Vol. 342, pp. 128323. Date of Electronic Publication: 2020 Oct 08.
Typ publikacji :
Journal Article
MeSH Terms :
Fruit/*metabolism
Inflorescence/*metabolism
Plants, Edible/*metabolism
Caco-2 Cells ; Caffeic Acids ; Glycoside Hydrolase Inhibitors/pharmacology ; Humans ; Hypoglycemic Agents/pharmacology ; Phenols/analysis ; Plant Extracts/pharmacology ; alpha-Amylases/antagonists & inhibitors ; alpha-Glucosidases/metabolism
Czasopismo naukowe
Tytuł :
Improving Oral Bioavailability of Luteolin Nanocrystals by Surface Modification of Sodium Dodecyl Sulfate.
Autorzy :
Liu J; National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330006, People's Republic of China.
Sun Y; National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330006, People's Republic of China.
Cheng M; National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330006, People's Republic of China.
Liu Q; National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330006, People's Republic of China.; School of Pharmacy, Guangxi University of Chinese Medicine, Nanning, 530200, People's Republic of China.
Liu W; National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330006, People's Republic of China.
Gao C; National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330006, People's Republic of China.
Feng J; National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330006, People's Republic of China. .; School of Pharmacy, Guangxi University of Chinese Medicine, Nanning, 530200, People's Republic of China. .
Jin Y; National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330006, People's Republic of China.
Tu L; National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330006, People's Republic of China. .
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Źródło :
AAPS PharmSciTech [AAPS PharmSciTech] 2021 Apr 14; Vol. 22 (3), pp. 133. Date of Electronic Publication: 2021 Apr 14.
Typ publikacji :
Journal Article
MeSH Terms :
Luteolin/*chemical synthesis
Luteolin/*pharmacokinetics
Nanoparticles/*chemistry
Nanoparticles/*metabolism
Sodium Dodecyl Sulfate/*chemical synthesis
Sodium Dodecyl Sulfate/*pharmacokinetics
Administration, Oral ; Animals ; Biological Availability ; Caco-2 Cells ; Cell Survival/drug effects ; Cell Survival/physiology ; Humans ; Luteolin/administration & dosage ; Male ; Nanoparticles/administration & dosage ; Particle Size ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Sodium Dodecyl Sulfate/administration & dosage ; Solubility ; Surface Properties
Czasopismo naukowe
Tytuł :
EpCAM promotes endosomal modulation of the cortical RhoA zone for epithelial organization.
Autorzy :
Gaston C; Cell Adhesion and Mechanics, Institut Jacques Monod, CNRS UMR7592, Paris Diderot University, Paris, France.
De Beco S; Cell Adhesion and Mechanics, Institut Jacques Monod, CNRS UMR7592, Paris Diderot University, Paris, France.
Doss B; Mechanobiology Institute, T-lab, Singapore, Singapore.
Pan M; Mechanobiology Institute, T-lab, Singapore, Singapore.
Gauquelin E; Cell Adhesion and Mechanics, Institut Jacques Monod, CNRS UMR7592, Paris Diderot University, Paris, France.
D'Alessandro J; Cell Adhesion and Mechanics, Institut Jacques Monod, CNRS UMR7592, Paris Diderot University, Paris, France.
Lim CT; Mechanobiology Institute, T-lab, Singapore, Singapore.
Ladoux B; Cell Adhesion and Mechanics, Institut Jacques Monod, CNRS UMR7592, Paris Diderot University, Paris, France.
Delacour D; Cell Adhesion and Mechanics, Institut Jacques Monod, CNRS UMR7592, Paris Diderot University, Paris, France. .
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Źródło :
Nature communications [Nat Commun] 2021 Apr 13; Vol. 12 (1), pp. 2226. Date of Electronic Publication: 2021 Apr 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Endosomes/*metabolism
Epithelial Cell Adhesion Molecule/*metabolism
Epithelial Cells/*metabolism
rhoA GTP-Binding Protein/*metabolism
Actomyosin/metabolism ; Caco-2 Cells ; Cell Movement/physiology ; Cell Polarity ; Cell Shape ; HeLa Cells ; Humans ; Myosin Type II/metabolism ; Stress Fibers/metabolism
Czasopismo naukowe
Tytuł :
High-throughput fitness screening and transcriptomics identify a role for a type IV secretion system in the pathogenesis of Crohn's disease-associated Escherichia coli.
Autorzy :
Elhenawy W; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada.; Michael G. DeGroote Institute for Infectious Disease Research, Hamilton, ON, Canada.
Hordienko S; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada.
Gould S; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada.
Oberc AM; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada.
Tsai CN; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada.
Hubbard TP; Division of Infectious Diseases, Brigham & Women's Hospital, Boston, MA, USA.; Department of Microbiology, Harvard Medical School, Boston, MA, USA.
Waldor MK; Division of Infectious Diseases, Brigham & Women's Hospital, Boston, MA, USA.; Department of Microbiology, Harvard Medical School, Boston, MA, USA.; Howard Hughes Medical Institute, Boston, MA, USA.
Coombes BK; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada. .; Michael G. DeGroote Institute for Infectious Disease Research, Hamilton, ON, Canada. .; Farncombe Family Digestive Health Research Institute, Hamilton, ON, Canada. .
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Źródło :
Nature communications [Nat Commun] 2021 Apr 01; Vol. 12 (1), pp. 2032. Date of Electronic Publication: 2021 Apr 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Crohn Disease/*pathology
Escherichia coli/*genetics
Gene Expression Profiling/*methods
High-Throughput Screening Assays/*methods
Type IV Secretion Systems/*genetics
Animals ; Bacterial Adhesion/genetics ; Biofilms ; Caco-2 Cells ; Crohn Disease/microbiology ; Epithelial Cells/metabolism ; Epithelial Cells/microbiology ; Escherichia coli/classification ; Escherichia coli/physiology ; Escherichia coli Infections/microbiology ; Escherichia coli Infections/pathology ; Female ; Humans ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/microbiology ; Mice, Inbred C57BL ; Virulence Factors/genetics
Czasopismo naukowe
Tytuł :
Enhanced Oral Bioavailability and Improved Biological Activities of a Quercetin/Resveratrol Combination Using a Liquid Self-Microemulsifying Drug Delivery System.
Autorzy :
Jaisamut P; Faculty of Traditional Thai Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
Wanna S; Faculty of Traditional Thai Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
Limsuwan S; Faculty of Traditional Thai Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
Chusri S; Faculty of Traditional Thai Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
Wiwattanawongsa K; Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
Wiwattanapatapee R; Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
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Źródło :
Planta medica [Planta Med] 2021 Apr; Vol. 87 (4), pp. 336-346. Date of Electronic Publication: 2020 Nov 11.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Delivery Systems*
Quercetin*
Administration, Oral ; Animals ; Biological Availability ; Caco-2 Cells ; Emulsions ; Humans ; Particle Size ; Rats ; Resveratrol ; Solubility
Czasopismo naukowe

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