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Wyszukujesz frazę ""Calcium Channels"" wg kryterium: Temat


Tytuł :
Interaction of MDIMP with the Voltage-Gated Calcium Channels.
Autorzy :
De La Rosa JAM; Departamento de Bioquímica (J.A.M.D.L.R., M.G.-C., G.Á.) and Departamento de Química (T.M.-P.), Cinvestav-IPN, Mexico City, Mexico and Instituto de Biotecnología (T.N.) and Instituto de Fisiología Celular (J.C.G.), Universidad Nacional Autónoma de México, Cuernavaca, Mexico.
García-Castañeda M; Departamento de Bioquímica (J.A.M.D.L.R., M.G.-C., G.Á.) and Departamento de Química (T.M.-P.), Cinvestav-IPN, Mexico City, Mexico and Instituto de Biotecnología (T.N.) and Instituto de Fisiología Celular (J.C.G.), Universidad Nacional Autónoma de México, Cuernavaca, Mexico.
Nishigaki T; Departamento de Bioquímica (J.A.M.D.L.R., M.G.-C., G.Á.) and Departamento de Química (T.M.-P.), Cinvestav-IPN, Mexico City, Mexico and Instituto de Biotecnología (T.N.) and Instituto de Fisiología Celular (J.C.G.), Universidad Nacional Autónoma de México, Cuernavaca, Mexico.
Gómora JC; Departamento de Bioquímica (J.A.M.D.L.R., M.G.-C., G.Á.) and Departamento de Química (T.M.-P.), Cinvestav-IPN, Mexico City, Mexico and Instituto de Biotecnología (T.N.) and Instituto de Fisiología Celular (J.C.G.), Universidad Nacional Autónoma de México, Cuernavaca, Mexico.
Mancilla-Percino T; Departamento de Bioquímica (J.A.M.D.L.R., M.G.-C., G.Á.) and Departamento de Química (T.M.-P.), Cinvestav-IPN, Mexico City, Mexico and Instituto de Biotecnología (T.N.) and Instituto de Fisiología Celular (J.C.G.), Universidad Nacional Autónoma de México, Cuernavaca, Mexico.
Ávila G; Departamento de Bioquímica (J.A.M.D.L.R., M.G.-C., G.Á.) and Departamento de Química (T.M.-P.), Cinvestav-IPN, Mexico City, Mexico and Instituto de Biotecnología (T.N.) and Instituto de Fisiología Celular (J.C.G.), Universidad Nacional Autónoma de México, Cuernavaca, Mexico .
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Źródło :
Molecular pharmacology [Mol Pharmacol] 2020 Sep; Vol. 98 (3), pp. 211-221. Date of Electronic Publication: 2020 Jun 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium Channels, L-Type/*chemistry
Calcium Channels, L-Type/*metabolism
Isoindoles/*chemical synthesis
Isoindoles/*pharmacology
Calcium Channels, R-Type/metabolism ; Calcium Channels, T-Type/metabolism ; Cation Transport Proteins/metabolism ; HEK293 Cells ; Humans ; Isoindoles/chemistry
Czasopismo naukowe
Tytuł :
Long-chain fatty dihydropyridines: Docking calcium channel studies and antihypertensive activity.
Autorzy :
Santa-Helena E; Postgraduate Program in Physiological Sciences, Institute of Biological Sciences, Federal University of Rio Grande - FURG, Rio Grande, RS, Brazil; Institute of Biological Sciences, Federal University of Rio Grande - FURG, Rio Grande, RS, Brazil.
Cabrera DDC; Kolbe Organic Synthesis Laboratory, School of Chemistry and Food, FURG, Rio Grande, RS.
D'Oca MGM; Kolbe Organic Synthesis Laboratory, School of Chemistry and Food, FURG, Rio Grande, RS.
Scaini JLR; Computational Biology Laboratory, Computational Sciences Center, FURG, Rio Grande, RS.
de Oliveira MWB; Computational Biology Laboratory, Computational Sciences Center, FURG, Rio Grande, RS.
Werhli AV; Computational Biology Laboratory, Computational Sciences Center, FURG, Rio Grande, RS.
Machado KDS; Computational Biology Laboratory, Computational Sciences Center, FURG, Rio Grande, RS.
Gonçalves CAN; Postgraduate Program in Physiological Sciences, Institute of Biological Sciences, Federal University of Rio Grande - FURG, Rio Grande, RS, Brazil; Institute of Biological Sciences, Federal University of Rio Grande - FURG, Rio Grande, RS, Brazil.
Nery LEM; Postgraduate Program in Physiological Sciences, Institute of Biological Sciences, Federal University of Rio Grande - FURG, Rio Grande, RS, Brazil; Institute of Biological Sciences, Federal University of Rio Grande - FURG, Rio Grande, RS, Brazil. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Oct 15; Vol. 259, pp. 118210. Date of Electronic Publication: 2020 Aug 05.
Typ publikacji :
Journal Article
MeSH Terms :
Calcium Channels, L-Type/*metabolism
Calcium Channels, L-Type/*ultrastructure
Dihydropyridines/*pharmacology
Animals ; Antihypertensive Agents/pharmacology ; Antioxidants/pharmacology ; Blood Pressure/drug effects ; Calcium/pharmacology ; Calcium Channel Blockers/pharmacology ; Calcium Channels ; Dihydropyridines/metabolism ; Heart Rate/drug effects ; Hypertension/physiopathology ; Male ; Nifedipine/pharmacology ; Pyridines/pharmacology ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
The native ORAI channel trio underlies the diversity of Ca signaling events.
Autorzy :
Yoast RE; Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA, 17033, USA.
Emrich SM; Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA, 17033, USA.
Zhang X; Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA, 17033, USA.
Xin P; Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA, 17033, USA.
Johnson MT; Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA, 17033, USA.
Fike AJ; Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA, 17033, USA.
Walter V; Department of Public Health Sciences, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA, 17033, USA.; Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA, 17033, USA.; Penn State Cancer Institute and The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA, 17033, USA.
Hempel N; Penn State Cancer Institute and The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA, 17033, USA.; Department of Pharmacology, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA, 17033, USA.
Yule DI; Department of Pharmacology and Physiology, University of Rochester Medical Center School of Medicine and Dentistry, 601 Elmwood Avenue, Box 711, Rochester, NY, 14642, USA.
Sneyd J; Department of Mathematics, The University of Auckland, 38 Princes Street, Auckland, 1010, New Zealand.
Gill DL; Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA, 17033, USA.
Trebak M; Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA, 17033, USA. .; Penn State Cancer Institute and The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA, 17033, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 May 15; Vol. 11 (1), pp. 2444. Date of Electronic Publication: 2020 May 15.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Calcium Signaling*/drug effects
Calcium Release Activated Calcium Channels/*metabolism
Calcium/metabolism ; Calcium Channels/metabolism ; Carbachol/pharmacology ; Endoplasmic Reticulum/drug effects ; Endoplasmic Reticulum/metabolism ; HEK293 Cells ; Humans ; Models, Biological ; NFATC Transcription Factors/metabolism ; ORAI1 Protein/metabolism ; Protein Binding/drug effects ; Protein Isoforms/metabolism ; Protein Multimerization/drug effects ; Stromal Interaction Molecule 1/metabolism ; Time-Lapse Imaging
Czasopismo naukowe
Tytuł :
α2δ-2 Protein Controls Structure and Function at the Cerebellar Climbing Fiber Synapse.
Autorzy :
Beeson KA; Neuroscience Graduate Program.; Department of Anesthesiology and Perioperative Medicine.
Beeson R; Department of Aerospace Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, and.
Westbrook GL; The Vollum Institute, Oregon Health & Science University, Portland, Oregon 97239.
Schnell E; Department of Anesthesiology and Perioperative Medicine, .; Operative Care Division, Portland VA Health Care System, Portland, Oregon 97239.
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2020 Mar 18; Vol. 40 (12), pp. 2403-2415. Date of Electronic Publication: 2020 Feb 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Calcium Channels/*physiology
Cerebellum/*physiology
Nerve Fibers/*physiology
Purkinje Cells/*physiology
Synapses/*physiology
Animals ; Calcium Channels, L-Type ; Cerebellum/cytology ; Computer Simulation ; Excitatory Postsynaptic Potentials/physiology ; Glutamic Acid/metabolism ; Mice, Inbred C57BL ; Mice, Knockout ; Models, Neurological ; Patch-Clamp Techniques ; Presynaptic Terminals/physiology ; Presynaptic Terminals/ultrastructure
Czasopismo naukowe
Tytuł :
A homozygous missense variant in CACNB4 encoding the auxiliary calcium channel beta4 subunit causes a severe neurodevelopmental disorder and impairs channel and non-channel functions.
Autorzy :
Coste de Bagneaux P; Department of Physiology and Medical Physics, Medical University Innsbruck, Innsbruck, Austria.
von Elsner L; Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Bierhals T; Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Campiglio M; Department of Physiology and Medical Physics, Medical University Innsbruck, Innsbruck, Austria.
Johannsen J; Childrens Hospital, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Obermair GJ; Department of Physiology and Medical Physics, Medical University Innsbruck, Innsbruck, Austria.; Division Physiology, Karl Landsteiner University of Health Sciences, Krems, Austria.
Hempel M; Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Flucher BE; Department of Physiology and Medical Physics, Medical University Innsbruck, Innsbruck, Austria.
Kutsche K; Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
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Źródło :
PLoS genetics [PLoS Genet] 2020 Mar 16; Vol. 16 (3), pp. e1008625. Date of Electronic Publication: 2020 Mar 16 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium Channels/*genetics
Mutation, Missense/*genetics
Neurodevelopmental Disorders/*genetics
Protein Subunits/*genetics
Animals ; Calcium/metabolism ; Calcium Channels, N-Type/genetics ; Cells, Cultured ; Female ; Gene Expression Regulation/genetics ; HEK293 Cells ; Hippocampus/physiology ; Homozygote ; Humans ; Male ; Mice, Inbred BALB C ; Neurons/metabolism ; Presynaptic Terminals/physiology ; Protein Isoforms/genetics ; Rats ; Synaptic Transmission/genetics
Czasopismo naukowe
Tytuł :
Plant Sense: The Rise of Calcium Channels.
Autorzy :
Kong X; The Key Laboratory of Plant Development and Environmental Adaptation Biology, Ministry of Education, College of Life Sciences, Shandong University, Qingdao, 266237, Shandong, China; Department of Biochemistry and Biophysics, and Institute for Plant Genomics and Biotechnology, Texas A&M University, College Station, TX 77843, USA. Electronic address: .
Xu L; Department of Biochemistry and Biophysics, and Institute for Plant Genomics and Biotechnology, Texas A&M University, College Station, TX 77843, USA.
Jamieson P; Department of Plant Pathology and Microbiology, and Institute for Plant Genomics and Biotechnology, Texas A&M University, College Station, TX 77843, USA.
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Źródło :
Trends in plant science [Trends Plant Sci] 2020 Sep; Vol. 25 (9), pp. 838-841. Date of Electronic Publication: 2020 Jun 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium*/metabolism
Calcium Channels*/genetics
Calcium Channels*/metabolism
Calcium Signaling ; Plants/metabolism ; Sodium Chloride
Czasopismo naukowe
Tytuł :
Ca Channels Mediate Bidirectional Signaling between Sarcolemma and Sarcoplasmic Reticulum in Muscle Cells.
Autorzy :
Avila G; Department of Biochemistry, Cinvestav-IPN. AP 14-740, México City, DF 07000, Mexico.
de la Rosa JA; Department of Biochemistry, Cinvestav-IPN. AP 14-740, México City, DF 07000, Mexico.
Monsalvo-Villegas A; Department of Biochemistry, Cinvestav-IPN. AP 14-740, México City, DF 07000, Mexico.
Montiel-Jaen MG; Department of Biochemistry, Cinvestav-IPN. AP 14-740, México City, DF 07000, Mexico.
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Źródło :
Cells [Cells] 2019 Dec 24; Vol. 9 (1). Date of Electronic Publication: 2019 Dec 24.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Calcium Channels/*metabolism
Calcium Channels/*physiology
Sarcolemma/*metabolism
Sarcoplasmic Reticulum/*metabolism
Calcium/metabolism ; Calcium Channels, L-Type/metabolism ; Calcium Channels, L-Type/physiology ; Cytosol/metabolism ; Excitation Contraction Coupling/physiology ; Humans ; Muscle, Skeletal/metabolism ; Myocytes, Cardiac/metabolism ; Ryanodine Receptor Calcium Release Channel/metabolism ; Sarcolemma/physiology ; Sarcoplasmic Reticulum/physiology ; Signal Transduction
Czasopismo naukowe
Tytuł :
High-Voltage-Activated Calcium Channel in the Afferent Pain Pathway: An Important Target of Pain Therapies.
Autorzy :
Li Q; Department of Anesthesiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, China.
Lu J; Department of Anesthesiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, China.; Department of Anesthesiology, The Second Affiliated Hospital of Jiaxing University, Jiaxing, 314000, China.
Zhou X; Department of Anesthesiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, China.
Chen X; Department of Anesthesiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, China.
Su D; Department of Anesthesiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, China.
Gu X; Department of Anesthesiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, China. .
Yu W; Department of Anesthesiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, China. .
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Źródło :
Neuroscience bulletin [Neurosci Bull] 2019 Dec; Vol. 35 (6), pp. 1073-1084. Date of Electronic Publication: 2019 May 07.
Typ publikacji :
Journal Article
MeSH Terms :
Calcium Channel Blockers/*pharmacology
Calcium Channels/*physiology
Pain/*physiopathology
Afferent Pathways ; Animals ; Calcium ; Calcium Channels/classification ; Calcium Channels, L-Type ; Calcium Channels, N-Type ; Humans ; Pain Management
Czasopismo naukowe
Tytuł :
T-type calcium channel antagonist, TTA-A2 exhibits anti-cancer properties in 3D spheroids of A549, a lung adenocarcinoma cell line.
Autorzy :
Kumari N; Department of Biomedical Engineering, Indian Institute of Technology Hyderabad, Telangana, India; Department of Biotechnology, Indian Institute of Technology Hyderabad, Telangana, India.
Bhargava A; Department of Biotechnology, Indian Institute of Technology Hyderabad, Telangana, India.
Rath SN; Department of Biomedical Engineering, Indian Institute of Technology Hyderabad, Telangana, India. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Nov 01; Vol. 260, pp. 118291. Date of Electronic Publication: 2020 Aug 15.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents*
Adenocarcinoma of Lung/*pathology
Benzeneacetamides/*pharmacology
Calcium Channel Blockers/*pharmacology
Calcium Channels, T-Type/*drug effects
Lung Neoplasms/*pathology
Pyridines/*pharmacology
A549 Cells ; Adenocarcinoma of Lung/drug therapy ; Benzeneacetamides/therapeutic use ; Calcium Channels, T-Type/physiology ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; HEK293 Cells ; Humans ; Lung Neoplasms/drug therapy ; Neoplasm Invasiveness/prevention & control ; Pyridines/therapeutic use
Czasopismo naukowe
Tytuł :
Pharmacological hypothesis: TPC2 antagonist tetrandrine as a potential therapeutic agent for COVID-19.
Autorzy :
Heister PM; University of Cambridge, Cambridge, United Kingdom.
Poston RN; Queen Mary University of London, London, United Kingdom.
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Źródło :
Pharmacology research & perspectives [Pharmacol Res Perspect] 2020 Oct; Vol. 8 (5), pp. e00653.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antiviral Agents/*administration & dosage
Benzylisoquinolines/*administration & dosage
Betacoronavirus/*drug effects
Calcium Channel Blockers/*administration & dosage
Calcium Channels/*drug effects
Coronavirus Infections/*drug therapy
Pneumonia, Viral/*drug therapy
Animals ; Antiviral Agents/adverse effects ; Benzylisoquinolines/adverse effects ; Betacoronavirus/pathogenicity ; Calcium Channel Blockers/adverse effects ; Calcium Channels/metabolism ; Coronavirus Infections/diagnosis ; Coronavirus Infections/metabolism ; Coronavirus Infections/virology ; Drug Interactions ; Host-Pathogen Interactions ; Humans ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/metabolism ; Pneumonia, Viral/virology ; Signal Transduction
SCR Disease Name :
COVID-19
Czasopismo naukowe
Tytuł :
How the mitochondrial calcium uniporter complex (MCU cx ) works.
Autorzy :
Boyman L; Center for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, MD 21201.; Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201.
Lederer WJ; Center for Biomedical Engineering and Technology, University of Maryland School of Medicine, Baltimore, MD 21201; .; Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Sep 15; Vol. 117 (37), pp. 22634-22636. Date of Electronic Publication: 2020 Sep 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Calcium*
Calcium Channels*
Mitochondria ; Mitochondrial Membranes
Czasopismo naukowe
Tytuł :
Coupled transmembrane mechanisms control MCU-mediated mitochondrial Ca uptake.
Autorzy :
Vais H; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Payne R; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Paudel U; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Li C; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Foskett JK; Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104; .; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Sep 01; Vol. 117 (35), pp. 21731-21739. Date of Electronic Publication: 2020 Aug 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Calcium/*metabolism
Calcium Channels/*metabolism
Mitochondria/*metabolism
Apoptosis ; Biological Transport ; Calcium/physiology ; Calcium Channels/physiology ; Calcium-Binding Proteins/metabolism ; Calcium-Binding Proteins/physiology ; Cation Transport Proteins/metabolism ; Cation Transport Proteins/physiology ; Cytoplasm/metabolism ; Cytosol/metabolism ; HEK293 Cells ; HeLa Cells ; Humans ; Membrane Potential, Mitochondrial/physiology ; Mitochondria/physiology ; Mitochondrial Membrane Transport Proteins/metabolism ; Mitochondrial Membrane Transport Proteins/physiology ; Mitochondrial Membranes/metabolism ; Mitochondrial Membranes/physiology ; Oxidation-Reduction ; Protein Multimerization ; Signal Transduction
Czasopismo naukowe
Tytuł :
T-type, but not L-type, voltage-gated calcium channels are dispensable for lymphatic pacemaking and spontaneous contractions.
Autorzy :
To KHT; Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, Missouri, 65212, USA.
Gui P; Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, Missouri, 65212, USA.
Li M; Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, Missouri, 65212, USA.
Zawieja SD; Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, Missouri, 65212, USA.
Castorena-Gonzalez JA; Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, Missouri, 65212, USA.
Davis MJ; Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, Missouri, 65212, USA. .
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Źródło :
Scientific reports [Sci Rep] 2020 Jan 09; Vol. 10 (1), pp. 70. Date of Electronic Publication: 2020 Jan 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Calcium Channels, T-Type/*genetics
Lymphatic Vessels/*physiology
Muscle Contraction/*physiology
Animals ; Calcium Channel Blockers/pharmacology ; Calcium Channels, L-Type/chemistry ; Calcium Channels, L-Type/genetics ; Calcium Channels, L-Type/metabolism ; Calcium Channels, T-Type/deficiency ; Calcium Channels, T-Type/metabolism ; Male ; Membrane Potentials/drug effects ; Mibefradil/pharmacology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Muscle Contraction/drug effects ; Myocytes, Smooth Muscle/cytology ; Myocytes, Smooth Muscle/metabolism ; Nickel/pharmacology ; Pacemaker, Artificial ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
Adult loss of Cacna1a in mice recapitulates childhood absence epilepsy by distinct thalamic bursting mechanisms.
Autorzy :
Miao QL; Developmental Neurogenetics Laboratory, Department of Neurology, Baylor College of Medicine, Houston TX, USA.
Herlitze S; Department of Zoology and Neurobiology, Ruhr University of Bochum, Bochum, Germany.
Mark MD; Department of Zoology and Neurobiology, Ruhr University of Bochum, Bochum, Germany.
Noebels JL; Developmental Neurogenetics Laboratory, Department of Neurology, Baylor College of Medicine, Houston TX, USA.; Department of Neuroscience, Baylor College of Medicine, Houston TX, USA.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston TX, USA.
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Źródło :
Brain : a journal of neurology [Brain] 2020 Jan 01; Vol. 143 (1), pp. 161-174.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Video-Audio Media
MeSH Terms :
Ataxia/*genetics
Calcium Channels, N-Type/*genetics
Cerebral Cortex/*metabolism
Epilepsy, Absence/*genetics
Neurons/*metabolism
Thalamus/*metabolism
Action Potentials ; Age Factors ; Animals ; Ataxia/metabolism ; Ataxia/physiopathology ; Calcium Channels, T-Type/genetics ; Calcium Channels, T-Type/metabolism ; Cerebral Cortex/physiopathology ; Disease Models, Animal ; Epilepsy, Absence/metabolism ; Epilepsy, Absence/physiopathology ; Excitatory Postsynaptic Potentials/genetics ; Inhibitory Postsynaptic Potentials/genetics ; Membrane Potentials/genetics ; Mice ; Mice, Knockout ; Patch-Clamp Techniques ; Thalamic Nuclei/cytology ; Thalamus/physiopathology
Czasopismo naukowe
Tytuł :
Mechanism of adrenergic Ca V 1.2 stimulation revealed by proximity proteomics.
Autorzy :
Liu G; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.
Papa A; Department of Physiology and Cellular Biophysics, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.
Katchman AN; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.
Zakharov SI; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.
Roybal D; Department of Pharmacology, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.
Hennessey JA; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.
Kushner J; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.
Yang L; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.
Chen BX; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.
Kushnir A; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.
Dangas K; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.
Gygi SP; Department of Cell Biology, Harvard Medical School, Boston, MA, USA.
Pitt GS; Cardiovascular Research Institute, Weill Cornell Medical College, New York, NY, USA.
Colecraft HM; Department of Physiology and Cellular Biophysics, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.; Department of Pharmacology, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.
Ben-Johny M; Department of Physiology and Cellular Biophysics, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA.
Kalocsay M; Department of Systems Biology, Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA. .
Marx SO; Division of Cardiology, Department of Medicine, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA. .; Department of Pharmacology, Columbia University, Vagelos College of Physicians and Surgeons, New York, NY, USA. .
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Źródło :
Nature [Nature] 2020 Jan; Vol. 577 (7792), pp. 695-700. Date of Electronic Publication: 2020 Jan 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Proteomics*
Calcium Channels, L-Type/*metabolism
Receptors, Adrenergic, beta/*metabolism
Animals ; Calcium Channels, L-Type/chemistry ; Calcium Channels, N-Type/metabolism ; Cellular Microenvironment ; Cyclic AMP/metabolism ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Female ; HEK293 Cells ; Heterotrimeric GTP-Binding Proteins/metabolism ; Humans ; Male ; Mice ; Monomeric GTP-Binding Proteins/metabolism ; Myocardium/metabolism ; Phosphorylation ; Protein Domains ; Protein Subunits/chemistry ; Protein Subunits/metabolism ; Signal Transduction ; ras Proteins/chemistry ; ras Proteins/metabolism
Czasopismo naukowe
Tytuł :
Aberrant calcium channel splicing drives defects in cortical differentiation in Timothy syndrome.
Autorzy :
Panagiotakos G; Department of Neurobiology, Stanford University School of Medicine, Stanford, United States.; Eli & Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, United States.; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, United States.
Haveles C; Eli & Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, United States.; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, United States.
Arjun A; Eli & Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, United States.; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, United States.; Graduate Program in Developmental and Stem Cell Biology, University of California, San Francisco, San Francisco, United States.
Petrova R; Eli & Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, United States.; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, United States.
Rana A; Graduate Program in Biochemistry, Stanford University School of Medicine, Stanford, United States.
Portmann T; Department of Neurobiology, Stanford University School of Medicine, Stanford, United States.
Paşca SP; Department of Neurobiology, Stanford University School of Medicine, Stanford, United States.; Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, United States.
Palmer TD; Department of Neurosurgery, Stanford University School of Medicine, Stanford, United States.
Dolmetsch RE; Department of Neurobiology, Stanford University School of Medicine, Stanford, United States.
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Źródło :
ELife [Elife] 2019 Dec 23; Vol. 8. Date of Electronic Publication: 2019 Dec 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Alternative Splicing/*physiology
Autism Spectrum Disorder/*metabolism
Calcium Channels/*metabolism
Cell Differentiation/*physiology
Animals ; Autism Spectrum Disorder/genetics ; Autism Spectrum Disorder/pathology ; Autistic Disorder ; Brain/embryology ; Brain/growth & development ; Calcium ; Calcium Channels/genetics ; Calcium Channels, L-Type/genetics ; Calcium Channels, L-Type/metabolism ; Cerebral Cortex/embryology ; Cerebral Cortex/metabolism ; Exons ; Gene Expression Regulation, Developmental ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Long QT Syndrome ; Matrix Attachment Region Binding Proteins/metabolism ; Mice ; Models, Animal ; Mutation ; Neurogenesis ; Neurons/cytology ; Neurons/metabolism ; RNA Splicing ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Syndactyly ; Transcription Factors/metabolism ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism
SCR Disease Name :
Timothy syndrome
Czasopismo naukowe
Tytuł :
Synapse and Active Zone Assembly in the Absence of Presynaptic Ca Entry.
Autorzy :
Held RG; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Liu C; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Ma K; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA; State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, and University of the Chinese Academy of Sciences, Beijing 100101, China.
Ramsey AM; Department of Physiology and Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Tarr TB; Department of Physiology and Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
De Nola G; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Wang SSH; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Wang J; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
van den Maagdenberg AMJM; Departments of Human Genetics and Neurology, Leiden University Medical Center, 2333 ZA Leiden, the Netherlands.
Schneider T; Institute for Neurophysiology, University of Cologne, Köln 50931, Germany.
Sun J; State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, and University of the Chinese Academy of Sciences, Beijing 100101, China.
Blanpied TA; Department of Physiology and Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Kaeser PS; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: .
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Źródło :
Neuron [Neuron] 2020 Aug 19; Vol. 107 (4), pp. 667-683.e9. Date of Electronic Publication: 2020 Jun 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium Channels/*metabolism
Presynaptic Terminals/*metabolism
Synapses/*metabolism
Synaptic Transmission/*physiology
Animals ; Calcium/metabolism ; Calcium Channels/genetics ; Exocytosis/physiology ; Mice, Knockout ; Neurons/metabolism ; Synaptic Vesicles/metabolism
Czasopismo naukowe
Tytuł :
CACNA1S haploinsufficiency confers resistance to New World arenavirus infection.
Autorzy :
Sarute N; Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, IL 60612.
Ross SR; Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, IL 60612 .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Aug 11; Vol. 117 (32), pp. 19497-19506. Date of Electronic Publication: 2020 Jul 27.
Typ publikacji :
Journal Article
MeSH Terms :
Arenaviridae Infections/*genetics
Calcium Channels, L-Type/*genetics
Disease Resistance/*genetics
Animals ; Arenaviridae Infections/drug therapy ; Arenaviruses, New World/physiology ; Calcium Channel Agonists/pharmacology ; Calcium Channel Agonists/therapeutic use ; Calcium Channel Blockers/pharmacology ; Calcium Channel Blockers/therapeutic use ; Calcium Channels, L-Type/deficiency ; Calcium Channels, L-Type/metabolism ; Cells, Cultured ; Dose-Response Relationship, Drug ; Heterozygote ; Humans ; Mice ; Mice, Mutant Strains ; Mutation ; Virus Attachment/drug effects ; Virus Internalization/drug effects
Czasopismo naukowe
Tytuł :
Emerging roles for α2δ subunits in calcium channel function and synaptic connectivity.
Autorzy :
Risher WC; Department of Biomedical Sciences, Joan C. Edwards School of Medicine at Marshall University, Huntington, WV 25705, United States. Electronic address: .
Eroglu C; Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, United States; Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, United States; Duke Institute for Brain Sciences (DIBS), Durham, NC 27710, United States; Regeneration Next Initiative, Duke University, Durham, NC 27710, United States.
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Źródło :
Current opinion in neurobiology [Curr Opin Neurobiol] 2020 Aug; Vol. 63, pp. 162-169. Date of Electronic Publication: 2020 Jun 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Calcium*/metabolism
Calcium Channels*/genetics
Calcium Channels*/metabolism
Protein Subunits/genetics ; Protein Subunits/metabolism ; Protein Transport ; Synapses/metabolism
Czasopismo naukowe

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