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Wyszukujesz frazę ""Calcium Channels, N-Type"" wg kryterium: Temat


Tytuł :
All Talk, No Assembly: Voltage-Gated Calcium Channels Do Not Mediate Active Zone Formation.
Autorzy :
Frankel EB; Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Kurshan PT; Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: .
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Źródło :
Neuron [Neuron] 2020 Aug 19; Vol. 107 (4), pp. 593-594.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Calcium*/metabolism
Calcium Channels, N-Type*/genetics
Neurons/metabolism ; Synapses/metabolism
Czasopismo naukowe
Tytuł :
Environmental Enrichment Enhances Ca v 2.1 Channel-Mediated Presynaptic Plasticity in Hypoxic-Ischemic Encephalopathy.
Autorzy :
Song SY; Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul 03722, Korea.; Graduate Program of NanoScience and Technology, Yonsei University, Seoul 03722, Korea.
Pyo S; Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul 03722, Korea.; Brain Korea 21 Plus Project for Medical Sciences, Yonsei University College of Medicine, Seoul 03722, Korea.
Choi S; Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul 03722, Korea.; Department of Medicine, Yonsei University College of Medicine, Seoul 03722, Korea.
Oh HS; Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul 03722, Korea.; Department of Medicine, Yonsei University College of Medicine, Seoul 03722, Korea.
Seo JH; Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul 03722, Korea.
Yu JH; Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul 03722, Korea.
Baek A; Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul 03722, Korea.; Department of Rehabilitation Medicine, Yonsei University Wonju College of Medicine, Wonju 26493, Korea.
Shin YK; Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul 03722, Korea.
Lee HY; Department of Medicine, the Graduate School of Yonsei University, Seoul 03722, Korea.; TBI Rehabilitation Center, National Traffic Injury Rehabilitation Hospital, Gyeonggi-do, Yangpyeong 12564, Korea.; Department of Rehabilitation Medicine, Seoul National University Hospital, Seoul University College of Medicine, Seoul 03080, Korea.; National Traffic Injury Rehabilitation Research Institute, National Traffic Injury Rehabilitation Hospital, Yangpyeong 12564, Korea.
Choi JY; Department of Rehabilitation Medicine, Chungnam National University Hospital, Chungnam National University College of Medicine, Daejeon 35015, Korea.
Cho SR; Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul 03722, Korea.; Graduate Program of NanoScience and Technology, Yonsei University, Seoul 03722, Korea.; Brain Korea 21 Plus Project for Medical Sciences, Yonsei University College of Medicine, Seoul 03722, Korea.; Rehabilitation Institute of Neuromuscular Disease, Yonsei University College of Medicine, Seoul 03722, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 26; Vol. 22 (7). Date of Electronic Publication: 2021 Mar 26.
Typ publikacji :
Journal Article
MeSH Terms :
Environment*
Neuronal Plasticity*
Perception*
Calcium Channels, N-Type/*metabolism
Hypoxia-Ischemia, Brain/*metabolism
Animals ; Cerebral Cortex/metabolism ; Cognition ; Hippocampus/metabolism ; Hypoxia-Ischemia, Brain/physiopathology ; Hypoxia-Ischemia, Brain/therapy ; Locomotion ; Male ; Mice ; Mice, Inbred ICR ; Spatial Learning
Czasopismo naukowe
Tytuł :
Cell-specific exon methylation and CTCF binding in neurons regulate calcium ion channel splicing and function.
Autorzy :
López Soto EJ; The Robert J and Nancy D Carney Institute for Brain Science & Department of Neuroscience, Brown University, Providence, United States.
Lipscombe D; The Robert J and Nancy D Carney Institute for Brain Science & Department of Neuroscience, Brown University, Providence, United States.
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Źródło :
ELife [Elife] 2020 Mar 26; Vol. 9. Date of Electronic Publication: 2020 Mar 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Alternative Splicing*
DNA Methylation*
Exons*
CCCTC-Binding Factor/*metabolism
Calcium Channels, N-Type/*genetics
Neurons/*metabolism
Animals ; Calcium Channels, N-Type/physiology ; Cell Lineage ; Cells, Cultured ; DNA (Cytosine-5-)-Methyltransferases/physiology ; Ganglia, Spinal/metabolism ; Mice ; Peripheral Nerve Injuries/metabolism ; TRPV Cation Channels/physiology
Czasopismo naukowe
Tytuł :
Conserved biophysical features of the Ca V 2 presynaptic Ca channel homologue from the early-diverging animal Trichoplax adhaerens .
Autorzy :
Gauberg J; Department of Biology, University of Toronto Mississauga, Mississauga, Ontario, Canada.
Abdallah S; Department of Biology, University of Toronto Mississauga, Mississauga, Ontario, Canada.
Elkhatib W; Department of Biology, University of Toronto Mississauga, Mississauga, Ontario, Canada.
Harracksingh AN; Department of Biology, University of Toronto Mississauga, Mississauga, Ontario, Canada.
Piekut T; Department of Biology, University of Toronto Mississauga, Mississauga, Ontario, Canada.
Stanley EF; Laboratory of Synaptic Transmission, Krembil Research Institute, Toronto, Ontario, Canada.
Senatore A; Department of Biology, University of Toronto Mississauga, Mississauga, Ontario, Canada. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2020 Dec 25; Vol. 295 (52), pp. 18553-18578. Date of Electronic Publication: 2020 Oct 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium Signaling*
Ion Channel Gating*
Synaptic Transmission*
Calcium/*metabolism
Calcium Channel Blockers/*pharmacology
Calcium Channels, N-Type/*chemistry
Calcium Channels, N-Type/*metabolism
Amino Acid Sequence ; Animals ; Cadmium/pharmacology ; Nickel/pharmacology ; Phylogeny ; Placozoa ; Sequence Homology, Amino Acid
Czasopismo naukowe
Tytuł :
An N-/L-type calcium channel blocker, cilnidipine, suppresses autonomic, electrical, and structural remodelling associated with atrial fibrillation.
Autorzy :
Tajiri K; Department of Medicine and Research Center, Montreal Heart Institute and Université de Montréal, Belanger St E, Montreal, Quebec, Canada.; Department of Cardiology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, Japan.
Guichard JB; Department of Medicine and Research Center, Montreal Heart Institute and Université de Montréal, Belanger St E, Montreal, Quebec, Canada.; Department of Cardiology, University Hospital of Saint-Étienne, University Jean Monnet, Saint-Étienne, France.
Qi X; Department of Medicine and Research Center, Montreal Heart Institute and Université de Montréal, Belanger St E, Montreal, Quebec, Canada.
Xiong F; Department of Medicine and Research Center, Montreal Heart Institute and Université de Montréal, Belanger St E, Montreal, Quebec, Canada.
Naud P; Department of Medicine and Research Center, Montreal Heart Institute and Université de Montréal, Belanger St E, Montreal, Quebec, Canada.
Tardif JC; Department of Medicine and Research Center, Montreal Heart Institute and Université de Montréal, Belanger St E, Montreal, Quebec, Canada.
Costa AD; Department of Cardiology, University Hospital of Saint-Étienne, University Jean Monnet, Saint-Étienne, France.
Aonuma K; Department of Cardiology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, Japan.
Nattel S; Department of Medicine and Research Center, Montreal Heart Institute and Université de Montréal, Belanger St E, Montreal, Quebec, Canada.; Department of Pharmacology and Therapeutics, McGill University, Promenade Sir-William-Osler, Montreal, Quebec, Canada.; Institute of Pharmacology, West German Heart and Vascular Center, Faculty of Medicine, University Duisburg-Essen, Hufelandstr. 55, Essen, Germany.; IHU LIRYC and Fondation Bordeaux Université, Avenue du Haut Lévêque, Pessac, Bordeaux, France.
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Źródło :
Cardiovascular research [Cardiovasc Res] 2019 Dec 01; Vol. 115 (14), pp. 1975-1985.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Arrhythmia Agents/*pharmacology
Atrial Fibrillation/*drug therapy
Atrial Function, Left/*drug effects
Atrial Remodeling/*drug effects
Calcium Channel Blockers/*pharmacology
Calcium Channels, N-Type/*drug effects
Dihydropyridines/*pharmacology
Heart Atria/*innervation
Presynaptic Terminals/*drug effects
Sympathetic Nervous System/*drug effects
Action Potentials/drug effects ; Animals ; Atrial Fibrillation/metabolism ; Atrial Fibrillation/physiopathology ; Calcium Channels, N-Type/metabolism ; Calcium Signaling/drug effects ; Connexin 43/metabolism ; Disease Models, Animal ; Dogs ; Fibrosis ; Heart Rate/drug effects ; Presynaptic Terminals/metabolism ; Sodium Channels/drug effects ; Sodium Channels/metabolism ; Sympathetic Nervous System/metabolism ; Sympathetic Nervous System/physiopathology
Czasopismo naukowe
Tytuł :
Differential regulation of Cav2.2 channel exon 37 variants by alternatively spliced μ-opioid receptors.
Autorzy :
Gandini MA; Department of Physiology and Pharmacology, Alberta Children's Hospital Research Institute, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Souza IA; Department of Physiology and Pharmacology, Alberta Children's Hospital Research Institute, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Raval D; Department of Physiology and Pharmacology, Alberta Children's Hospital Research Institute, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Xu J; Department of Neurology and the Molecular Pharmacology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Pan YX; Department of Neurology and the Molecular Pharmacology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
Zamponi GW; Department of Physiology and Pharmacology, Alberta Children's Hospital Research Institute, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. .
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Źródło :
Molecular brain [Mol Brain] 2019 Nov 27; Vol. 12 (1), pp. 98. Date of Electronic Publication: 2019 Nov 27.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Alternative Splicing/*genetics
Calcium Channels, N-Type/*genetics
Exons/*genetics
Receptors, Opioid, mu/*genetics
Animals ; Calcium Channels, N-Type/metabolism ; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-/pharmacology ; GTP-Binding Proteins/metabolism ; Ion Channel Gating/genetics ; Mice ; Protein-Tyrosine Kinases/metabolism ; Rats ; Receptors, Opioid, mu/metabolism
Czasopismo naukowe
Tytuł :
Probing Synaptic Signaling with Optogenetic Stimulation and Genetically Encoded Calcium Reporters.
Autorzy :
Borja GB; Q-State Biosciences Inc., Cambridge, MA, USA.
Shroff H; Q-State Biosciences Inc., Cambridge, MA, USA.
Upadhyay H; Q-State Biosciences Inc., Cambridge, MA, USA.
Liu PW; Q-State Biosciences Inc., Cambridge, MA, USA.
Baru V; Q-State Biosciences Inc., Cambridge, MA, USA.
Cheng YC; Q-State Biosciences Inc., Cambridge, MA, USA.
McManus OB; Q-State Biosciences Inc., Cambridge, MA, USA.
Williams LA; Q-State Biosciences Inc., Cambridge, MA, USA.
Dempsey GT; Q-State Biosciences Inc., Cambridge, MA, USA.
Werley CA; Q-State Biosciences Inc., Cambridge, MA, USA. .
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Źródło :
Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2191, pp. 109-134.
Typ publikacji :
Journal Article
MeSH Terms :
Calcium/*metabolism
Channelrhodopsins/*genetics
Neurons/*metabolism
Optogenetics/*methods
Animals ; Calcium Channels, N-Type/genetics ; Humans ; Rats ; Signal Transduction/genetics ; Synapses/genetics ; Synapsins/chemistry ; Synaptic Transmission/genetics
Czasopismo naukowe
Tytuł :
Phα1β, a dual blocker of TRPA1 and Cav2.2, as an adjuvant drug in opioid therapy for postoperative pain.
Autorzy :
Tonello R; Programa de Pós-graduação Em Ciências Biológicas: Bioquímica Toxicológica, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil; Programa de Pós-graduação Em Farmacologia, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.
Trevisan G; Programa de Pós-graduação Em Farmacologia, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
Luckemeyer D; Programa de Pós-graduação Em Farmacologia, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.
Castro-Junior CJ; Núcleo de Pós-graduação, Instituto de Ensino e Pesquisa da Santa Casa de Belo Horizonte, Belo Horizonte, MG, Brazil.
Gomez MV; Núcleo de Pós-graduação, Instituto de Ensino e Pesquisa da Santa Casa de Belo Horizonte, Belo Horizonte, MG, Brazil.
Ferreira J; Programa de Pós-graduação Em Ciências Biológicas: Bioquímica Toxicológica, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil; Programa de Pós-graduação Em Farmacologia, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil. Electronic address: .
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Źródło :
Toxicon : official journal of the International Society on Toxinology [Toxicon] 2020 Dec; Vol. 188, pp. 80-88. Date of Electronic Publication: 2020 Oct 07.
Typ publikacji :
Journal Article
MeSH Terms :
Analgesics, Opioid/*therapeutic use
Chemotherapy, Adjuvant/*methods
Pain, Postoperative/*drug therapy
Spider Venoms/*therapeutic use
Analgesics ; Animals ; Calcium Channels, N-Type/metabolism ; Hyperalgesia/chemically induced ; Mice ; Morphine ; Spider Venoms/pharmacology ; TRPA1 Cation Channel/metabolism
Czasopismo naukowe
Tytuł :
Cacna1b alternative splicing impacts excitatory neurotransmission and is linked to behavioral responses to aversive stimuli.
Autorzy :
Bunda A; Department of Biological Sciences, College of Life Sciences and Agriculture, University of New Hampshire, 46 College Road, Durham, NH, 03824, USA.
LaCarubba B; Department of Biological Sciences, College of Life Sciences and Agriculture, University of New Hampshire, 46 College Road, Durham, NH, 03824, USA.
Bertolino M; Department of Biological Sciences, College of Life Sciences and Agriculture, University of New Hampshire, 46 College Road, Durham, NH, 03824, USA.
Akiki M; Department of Biological Sciences, College of Life Sciences and Agriculture, University of New Hampshire, 46 College Road, Durham, NH, 03824, USA.
Bath K; Department of Cognitive, Linguistic and Psychological Sciences, Brown University, 190 Thayer Street, Providence, RI, 02912, USA.
Lopez-Soto J; Robert J and Nancy D Carney Institute for Brain Science & Department of Neuroscience, Brown University, 185 Meeting Street, Providence, RI, 02912, USA.
Lipscombe D; Robert J and Nancy D Carney Institute for Brain Science & Department of Neuroscience, Brown University, 185 Meeting Street, Providence, RI, 02912, USA.
Andrade A; Department of Biological Sciences, College of Life Sciences and Agriculture, University of New Hampshire, 46 College Road, Durham, NH, 03824, USA. .
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Źródło :
Molecular brain [Mol Brain] 2019 Oct 21; Vol. 12 (1), pp. 81. Date of Electronic Publication: 2019 Oct 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Behavior, Animal*
Alternative Splicing/*genetics
Calcium Channels, N-Type/*genetics
Synaptic Transmission/*genetics
Animals ; Brain/metabolism ; Calcium Channels, N-Type/metabolism ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/genetics ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Female ; Gene Expression Regulation ; Male ; Mice, Inbred C57BL ; Mice, Transgenic ; Neurons/metabolism ; Physical Stimulation ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Synapses/metabolism
Czasopismo naukowe
Tytuł :
Attenuation of renal fibrosis after unilateral ureteral obstruction in mice lacking the N-type calcium channel.
Autorzy :
Mishima K; Department of Nephrology and Rheumatology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Nakasatomi M; Department of Nephrology and Rheumatology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Takahashi S; Department of Nephrology and Rheumatology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Ikeuchi H; Department of Nephrology and Rheumatology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Sakairi T; Department of Nephrology and Rheumatology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Kaneko Y; Department of Nephrology and Rheumatology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Hiromura K; Department of Nephrology and Rheumatology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Nojima Y; Department of Nephrology and Rheumatology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Maeshima A; Department of Nephrology and Rheumatology, Gunma University Graduate School of Medicine, Maebashi, Japan.
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Źródło :
PloS one [PLoS One] 2019 Oct 09; Vol. 14 (10), pp. e0223496. Date of Electronic Publication: 2019 Oct 09 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium Channels, N-Type/*deficiency
Kidney Diseases/*metabolism
Actins/genetics ; Actins/metabolism ; Animals ; Calcium Channels, N-Type/genetics ; Cell Hypoxia ; Collagen Type I/genetics ; Collagen Type I/metabolism ; Fibrosis ; Kidney/metabolism ; Kidney/pathology ; Kidney Diseases/etiology ; Kidney Diseases/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Neurons/metabolism ; Tyrosine 3-Monooxygenase/genetics ; Tyrosine 3-Monooxygenase/metabolism ; Ureteral Obstruction/complications
Czasopismo naukowe
Tytuł :
Grina/TMBIM3 modulates voltage-gated Ca V 2.2 Ca channels in a G-protein-like manner.
Autorzy :
Mallmann RT; Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Fakultät für Medizin, Albert-Ludwigs-Universität Freiburg, Albertstr. 25, 79104 Freiburg, Germany.
Moravcikova L; Center of Bioscience - Institute for Molecular Physiology and Genetics, 84005 Bratislava, Slovakia.
Ondacova K; Center of Bioscience - Institute for Molecular Physiology and Genetics, 84005 Bratislava, Slovakia.
Lacinova L; Center of Bioscience - Institute for Molecular Physiology and Genetics, 84005 Bratislava, Slovakia.
Klugbauer N; Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Fakultät für Medizin, Albert-Ludwigs-Universität Freiburg, Albertstr. 25, 79104 Freiburg, Germany. Electronic address: n..
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Źródło :
Cell calcium [Cell Calcium] 2019 Jun; Vol. 80, pp. 71-78. Date of Electronic Publication: 2019 Apr 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium Channels, N-Type/*metabolism
Endoplasmic Reticulum/*metabolism
Fibroblasts/*metabolism
Membrane Proteins/*metabolism
Nerve Tissue Proteins/*metabolism
Receptors, N-Methyl-D-Aspartate/*metabolism
Action Potentials ; Animals ; Apoptosis/genetics ; Calcium Channels, N-Type/genetics ; Calcium Signaling ; Cells, Cultured ; GTP-Binding Protein beta Subunits/genetics ; GTP-Binding Protein beta Subunits/metabolism ; GTP-Binding Protein gamma Subunits/genetics ; GTP-Binding Protein gamma Subunits/metabolism ; Homeostasis ; Membrane Proteins/genetics ; Mice ; Nerve Tissue Proteins/genetics ; Patch-Clamp Techniques ; Protein Binding ; Receptors, N-Methyl-D-Aspartate/genetics
Czasopismo naukowe
Tytuł :
Presynaptic Calcium Channels.
Autorzy :
Mochida S; Department of Physiology, Tokyo Medical University, Tokyo 160-8402, Japan. .
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2019 May 06; Vol. 20 (9). Date of Electronic Publication: 2019 May 06.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Calcium Channels, N-Type/*metabolism
Presynaptic Terminals/*metabolism
Animals ; Calcium Channels, N-Type/genetics ; Calcium-Binding Proteins/metabolism ; Humans ; Presynaptic Terminals/physiology ; Synaptic Potentials
Czasopismo naukowe
Tytuł :
Primary and secondary motoneurons use different calcium channel types to control escape and swimming behaviors in zebrafish.
Autorzy :
Wen H; Vollum Institute, Oregon Health and Science University, Portland, OR 97239.
Eckenstein K; Vollum Institute, Oregon Health and Science University, Portland, OR 97239.
Weihrauch V; Imaging Core Facility, Biocenter, University of Würzburg, 97074 Würzburg, Germany.
Stigloher C; Imaging Core Facility, Biocenter, University of Würzburg, 97074 Würzburg, Germany.
Brehm P; Vollum Institute, Oregon Health and Science University, Portland, OR 97239; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Oct 20; Vol. 117 (42), pp. 26429-26437. Date of Electronic Publication: 2020 Oct 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Calcium Channels/*metabolism
Calcium Channels/*physiology
Motor Neurons/*metabolism
Animals ; Calcium/metabolism ; Calcium Channels, N-Type/metabolism ; Calcium Channels, P-Type/metabolism ; Calcium Channels, Q-Type/metabolism ; Escape Reaction/physiology ; Motor Neurons/physiology ; Neuromuscular Junction/metabolism ; Presynaptic Terminals/physiology ; Swimming/physiology ; Synapses/metabolism ; Zebrafish/metabolism
Czasopismo naukowe
Tytuł :
Intracerebroventricular administration of N-type calcium channel blocker ziconotide displays anticonvulsant, anxiolytic, and sedative effects in rats: A preclinical and pilot study.
Autorzy :
Zamani M; Department of Pharmacology, School of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran.
Budde T; Institute of Physiology I, Westfälische Wilhelms-University, Münster, Germany.
Bozorgi H; Department of Pharmacology, Research Center of Physiology, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran. Electronic address: .
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Źródło :
Epilepsy & behavior : E&B [Epilepsy Behav] 2020 Oct; Vol. 111, pp. 107251. Date of Electronic Publication: 2020 Jun 25.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Anxiety Agents/*administration & dosage
Anticonvulsants/*administration & dosage
Calcium Channel Blockers/*administration & dosage
Hypnotics and Sedatives/*administration & dosage
Seizures/*drug therapy
omega-Conotoxins/*administration & dosage
Animals ; Calcium Channels, N-Type/physiology ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical ; Male ; Pentylenetetrazole/toxicity ; Pilot Projects ; Rats ; Rats, Wistar ; Seizures/chemically induced ; Seizures/physiopathology
Czasopismo naukowe
Tytuł :
Deep Learning-Assisted High-Throughput Analysis of Freeze-Fracture Replica Images Applied to Glutamate Receptors and Calcium Channels at Hippocampal Synapses.
Autorzy :
Kleindienst D; Institute of Science and Technology (IST )Austria, 3400 Klosterneuburg, Austria.
Montanaro J; Institute of Science and Technology (IST )Austria, 3400 Klosterneuburg, Austria.
Bhandari P; Institute of Science and Technology (IST )Austria, 3400 Klosterneuburg, Austria.
Case MJ; Institute of Science and Technology (IST )Austria, 3400 Klosterneuburg, Austria.
Fukazawa Y; Department of Histological and Physiological Sciences, Faculty of Medical Science, University of Fukui, Yoshida, Fukui 910-1193, Japan.
Shigemoto R; Institute of Science and Technology (IST )Austria, 3400 Klosterneuburg, Austria.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Sep 14; Vol. 21 (18). Date of Electronic Publication: 2020 Sep 14.
Typ publikacji :
Journal Article
MeSH Terms :
Calcium Channels, N-Type/*metabolism
Hippocampus/*metabolism
Receptors, AMPA/*metabolism
Receptors, N-Methyl-D-Aspartate/*metabolism
Synapses/*metabolism
Animals ; Deep Learning ; Dendrites/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Microscopy, Electron/methods ; Neuronal Plasticity/physiology ; Signal Transduction/physiology ; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/metabolism
Czasopismo naukowe
Tytuł :
A Selectivity Filter Gate Controls Voltage-Gated Calcium Channel Calcium-Dependent Inactivation.
Autorzy :
Abderemane-Ali F; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 93858-2330, USA.
Findeisen F; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 93858-2330, USA.
Rossen ND; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 93858-2330, USA.
Minor DL Jr; Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 93858-2330, USA; Departments of Biochemistry and Biophysics, and Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 93858-2330, USA; California Institute for Quantitative Biomedical Research, University of California, San Francisco, San Francisco, CA 93858-2330, USA; Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA 93858-2330, USA; Molecular Biophysics and Integrated Bio-imaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. Electronic address: .
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Źródło :
Neuron [Neuron] 2019 Mar 20; Vol. 101 (6), pp. 1134-1149.e3. Date of Electronic Publication: 2019 Feb 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium/*metabolism
Calcium Channels, L-Type/*genetics
Calcium Channels, N-Type/*genetics
Ion Channel Gating/*genetics
Animals ; Aspartic Acid ; Calcium Channels, L-Type/metabolism ; Calcium Channels, N-Type/metabolism ; HEK293 Cells ; Humans ; Mutation ; Oocytes/metabolism ; Patch-Clamp Techniques ; Xenopus laevis
Czasopismo naukowe
Tytuł :
RIM and RIM-BP Form Presynaptic Active-Zone-like Condensates via Phase Separation.
Autorzy :
Wu X; Division of Life Science, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
Cai Q; Division of Life Science, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
Shen Z; Division of Life Science, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
Chen X; Division of Life Science, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
Zeng M; Division of Life Science, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
Du S; Department of Physics, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China; Department of Chemical and Biological Engineering, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China.
Zhang M; Division of Life Science, State Key Laboratory of Molecular Neuroscience, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China; Center of Systems Biology and Human Health, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2019 Mar 07; Vol. 73 (5), pp. 971-984.e5. Date of Electronic Publication: 2019 Jan 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media
MeSH Terms :
Adaptor Proteins, Signal Transducing/*metabolism
Calcium Channels, N-Type/*metabolism
GTP-Binding Proteins/*metabolism
Intracellular Signaling Peptides and Proteins/*metabolism
Presynaptic Terminals/*metabolism
Synaptic Membranes/*metabolism
Adaptor Proteins, Signal Transducing/genetics ; Animals ; Binding Sites ; Calcium Channels, N-Type/genetics ; GTP-Binding Proteins/genetics ; Intrinsically Disordered Proteins/genetics ; Intrinsically Disordered Proteins/metabolism ; Kinetics ; Membrane Microdomains/genetics ; Membrane Microdomains/metabolism ; Mice ; Protein Binding ; Protein Interaction Domains and Motifs ; Rats ; SNARE Proteins/genetics ; SNARE Proteins/metabolism ; Solubility ; Synaptic Membranes/genetics ; Synaptic Transmission
Czasopismo naukowe
Tytuł :
Structure, function and regulation of Ca V 2.2 N-type calcium channels.
Autorzy :
Jurkovicova-Tarabova B; Center of Biosciences, Institute of Molecular Physiology and Genetics, Academy of Sciences, Dubravska cesta 9, 840 05 Bratislava, Slovakia. .
Lacinova L
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Źródło :
General physiology and biophysics [Gen Physiol Biophys] 2019 Mar; Vol. 38 (2), pp. 101-110. Date of Electronic Publication: 2019 Mar 01.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Calcium Channel Blockers*
Calcium Channels, N-Type*
Animals ; Biophysical Phenomena ; Humans ; Mice ; Receptors, G-Protein-Coupled
Czasopismo naukowe
Tytuł :
The Role of Ca V 2.1 Channel Facilitation in Synaptic Facilitation.
Autorzy :
Weyrer C; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA; Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge CB2 3EG, UK.
Turecek J; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Niday Z; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Liu PW; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Nanou E; Department of Pharmacology, University of Washington, Seattle, WA 98195-7280, USA.
Catterall WA; Department of Pharmacology, University of Washington, Seattle, WA 98195-7280, USA.
Bean BP; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Regehr WG; Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: .
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Źródło :
Cell reports [Cell Rep] 2019 Feb 26; Vol. 26 (9), pp. 2289-2297.e3.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium Channels, N-Type/*physiology
Synapses/*physiology
Action Potentials ; Animals ; CA3 Region, Hippocampal/metabolism ; CA3 Region, Hippocampal/physiology ; Calcium/metabolism ; Calcium Channels, N-Type/genetics ; Excitatory Postsynaptic Potentials ; Gene Knock-In Techniques ; Mice ; Purkinje Cells/metabolism ; Purkinje Cells/physiology
Czasopismo naukowe
Tytuł :
Ca V 2.1 α 1 Subunit Expression Regulates Presynaptic Ca V 2.1 Abundance and Synaptic Strength at a Central Synapse.
Autorzy :
Lübbert M; Research Group Molecular Mechanisms of Synaptic Function, Max Planck Florida Institute for Neuroscience, Jupiter, FL 33458, USA.
Goral RO; Department of Anatomy and Cell Biology, Iowa Neuroscience Institute, University of Iowa, Iowa City, IA 52242, USA.
Keine C; Department of Anatomy and Cell Biology, Iowa Neuroscience Institute, University of Iowa, Iowa City, IA 52242, USA.
Thomas C; Max Planck Florida Electron Microscopy Core, Max Planck Florida Institute for Neuroscience, Jupiter, FL 33458, USA.
Guerrero-Given D; Max Planck Florida Electron Microscopy Core, Max Planck Florida Institute for Neuroscience, Jupiter, FL 33458, USA.
Putzke T; Research Group Molecular Mechanisms of Synaptic Function, Max Planck Florida Institute for Neuroscience, Jupiter, FL 33458, USA.
Satterfield R; Research Group Molecular Mechanisms of Synaptic Function, Max Planck Florida Institute for Neuroscience, Jupiter, FL 33458, USA.
Kamasawa N; Max Planck Florida Electron Microscopy Core, Max Planck Florida Institute for Neuroscience, Jupiter, FL 33458, USA.
Young SM Jr; Department of Anatomy and Cell Biology, Iowa Neuroscience Institute, University of Iowa, Iowa City, IA 52242, USA; Department of Otolaryngology, Iowa Neuroscience Institute, Aging Mind Brain Initiative, University of Iowa, Iowa City, IA 52242, USA. Electronic address: .
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Źródło :
Neuron [Neuron] 2019 Jan 16; Vol. 101 (2), pp. 260-273.e6. Date of Electronic Publication: 2018 Dec 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Brain Stem/*cytology
Calcium Channels, N-Type/*metabolism
Presynaptic Terminals/*physiology
Synapses/*physiology
Synaptic Transmission/*genetics
Animals ; Animals, Newborn ; Biophysics ; Cadmium Chloride/pharmacology ; Calcium/metabolism ; Calcium Channel Blockers/pharmacology ; Calcium Channels, N-Type/genetics ; Electric Stimulation ; Female ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Neurotransmitter Agents/metabolism ; Presynaptic Terminals/ultrastructure ; Synapses/ultrastructure
Czasopismo naukowe

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