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Wyszukujesz frazę ""Calmodulin"" wg kryterium: Temat


Tytuł :
Calmodulin Binding Proteins and Alzheimer's Disease: Biomarkers, Regulatory Enzymes and Receptors That Are Regulated by Calmodulin.
Autorzy :
O'Day DH; Cell and Systems Biology, University of Toronto, Toronto, ON M5S 3G5, Canada.; Department of Biology, University of Toronto Mississauga, Mississauga, ON L5L 1C6, Canada.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Oct 05; Vol. 21 (19). Date of Electronic Publication: 2020 Oct 05.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Alzheimer Disease/*genetics
Calmodulin/*genetics
Receptor, Adenosine A2A/*genetics
Stromal Interaction Molecule 2/*genetics
Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Calcium/metabolism ; Calcium Signaling/genetics ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/genetics ; Calmodulin/metabolism ; Calmodulin-Binding Proteins/classification ; Calmodulin-Binding Proteins/genetics ; Humans ; Neurogranin/genetics ; Neurons/metabolism ; Neurons/pathology ; Receptors, Glutamate/genetics
Czasopismo naukowe
Tytuł :
Calmodulin Binding to Connexin 35: Specializations to Function as an Electrical Synapse.
Autorzy :
Aseervatham J; Ruiz Department of Ophthalmology & Visual Science, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Li X; Ruiz Department of Ophthalmology & Visual Science, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Mitchell CK; Ruiz Department of Ophthalmology & Visual Science, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Lin YP; Ruiz Department of Ophthalmology & Visual Science, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Heidelberger R; Department of Neurobiology & Anatomy, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.; The MD Anderson Cancer Center/UTHealth Graduate School of Biomedical Sciences, Houston, TX 77030, USA.
O'Brien J; Ruiz Department of Ophthalmology & Visual Science, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.; The MD Anderson Cancer Center/UTHealth Graduate School of Biomedical Sciences, Houston, TX 77030, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Sep 01; Vol. 21 (17). Date of Electronic Publication: 2020 Sep 01.
Typ publikacji :
Journal Article
MeSH Terms :
Calmodulin/*metabolism
Connexins/*metabolism
Electrical Synapses/*physiology
Gap Junctions/*physiology
Calcium Signaling ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Calmodulin/genetics ; Connexins/genetics ; HeLa Cells ; Humans ; Mutation ; Phosphorylation ; Protein Binding ; Protein Transport
Czasopismo naukowe
Tytuł :
The Roles of Superoxide on At-Level Spinal Cord Injury Pain in Rats.
Autorzy :
Lee BH; Department of Acupuncture, Moxibustion and Acupoint, College of Korean Medicine, Daegu Haany University, Daegu 42158, Korea.; Research Center for Herbal Convergence on Liver Disease, Daegu Haany University, Daegu 42158, Korea.
Kang J; Department of Biology, Valdosta State University, Valdosta, GA 31698, USA.
Kim HY; Research Center for Herbal Convergence on Liver Disease, Daegu Haany University, Daegu 42158, Korea.; Department of Physiology, College of Korean Medicine, Daegu Haany University, Daegu 42158, Korea.
Gwak YS; Department of Physiology, College of Korean Medicine, Daegu Haany University, Daegu 42158, Korea.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 06; Vol. 22 (5). Date of Electronic Publication: 2021 Mar 06.
Typ publikacji :
Journal Article
MeSH Terms :
Calcium-Calmodulin-Dependent Protein Kinase Type 2/*physiology
Hyperalgesia/*drug therapy
Nerve Tissue Proteins/*physiology
Neuralgia/*drug therapy
Nociception/*drug effects
Spinal Cord Injuries/*drug therapy
Superoxides/*metabolism
Animals ; Benzylamines/pharmacology ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/biosynthesis ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/genetics ; Contusions/physiopathology ; Cyclic N-Oxides/pharmacology ; Free Radical Scavengers/therapeutic use ; Hyperalgesia/etiology ; Male ; Models, Animal ; Nerve Tissue Proteins/biosynthesis ; Nerve Tissue Proteins/genetics ; Neuralgia/etiology ; Pain Threshold/drug effects ; Rats ; Rats, Sprague-Dawley ; Reactive Oxygen Species/metabolism ; Receptors, Ionotropic Glutamate/drug effects ; Spin Labels ; Spinal Cord Dorsal Horn/drug effects ; Spinal Cord Injuries/physiopathology ; Sulfonamides/pharmacology ; Synaptic Transmission
Czasopismo naukowe
Tytuł :
CaMK II/Ca2+ dependent endoplasmic reticulum stress mediates apoptosis of hepatic stellate cells stimulated by transforming growth factor beta 1.
Autorzy :
Liu H; Department of Epidemiology and Health Statistics, School of Public Health, North China University of Science and Technology, Hebei, China.
Wang L; Department of Epidemiology and Health Statistics, School of Public Health, North China University of Science and Technology, Hebei, China.
Dai L; Department of Epidemiology and Health Statistics, School of Public Health, North China University of Science and Technology, Hebei, China.
Feng F; Department of Epidemiology and Health Statistics, School of Life Sciences, North China University of Science and Technology, Hebei, China.
Xiao Y; Department of Epidemiology and Health Statistics, School of Public Health, North China University of Science and Technology, Hebei, China. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Mar 01; Vol. 172, pp. 321-329. Date of Electronic Publication: 2021 Jan 15.
Typ publikacji :
Journal Article
MeSH Terms :
Calcium/*metabolism
Calcium-Calmodulin-Dependent Protein Kinase Type 2/*antagonists & inhibitors
Endoplasmic Reticulum Stress/*drug effects
Hepatic Stellate Cells/*drug effects
Transforming Growth Factor beta1/*pharmacology
Uridine Triphosphate/*pharmacology
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/analogs & derivatives ; 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/pharmacology ; Apoptosis/drug effects ; Apoptosis/genetics ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/genetics ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Caspase 12/genetics ; Caspase 12/metabolism ; Cations, Divalent ; Cell Line ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Endoplasmic Reticulum Stress/genetics ; Enzyme Inhibitors/pharmacology ; Gene Expression Regulation ; Heat-Shock Proteins/genetics ; Heat-Shock Proteins/metabolism ; Hepatic Stellate Cells/cytology ; Hepatic Stellate Cells/metabolism ; Humans ; Signal Transduction ; Uridine Triphosphate/metabolism ; bcl-2-Associated X Protein/genetics ; bcl-2-Associated X Protein/metabolism
Czasopismo naukowe
Tytuł :
Treadmill exercise enhances synaptic plasticity in the ischemic penumbra of MCAO mice by inducing the expression of Camk2a via CYFIP1 upregulation.
Autorzy :
Shen W; Physical Medicine and Rehabilitation Center, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, No. 109, Xueyuanxi Road, Wenzhou, Zhejiang, China.
Jin L; Physical Medicine and Rehabilitation Center, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, No. 109, Xueyuanxi Road, Wenzhou, Zhejiang, China.
Zhu A; Physical Medicine and Rehabilitation Center, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, No. 109, Xueyuanxi Road, Wenzhou, Zhejiang, China.
Lin Y; Physical Medicine and Rehabilitation Center, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, No. 109, Xueyuanxi Road, Wenzhou, Zhejiang, China.
Pan G; Physical Medicine and Rehabilitation Center, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, No. 109, Xueyuanxi Road, Wenzhou, Zhejiang, China.
Zhou S; Wenzhou Medical University, Wenzhou, Zhejiang, China.
Cheng J; The Second Hospital Affiliated to Anhui University of Chinese Medicine, No.300, Shouchun Road, Hefei, Anhui, China.
Zhang J; Physical Medicine and Rehabilitation Center, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, No. 109, Xueyuanxi Road, Wenzhou, Zhejiang, China.
Tu F; Physical Medicine and Rehabilitation Center, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, No. 109, Xueyuanxi Road, Wenzhou, Zhejiang, China.
Liu C; Physical Medicine and Rehabilitation Center, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, No. 109, Xueyuanxi Road, Wenzhou, Zhejiang, China.
Xie Q; Physical Medicine and Rehabilitation Center, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, No. 109, Xueyuanxi Road, Wenzhou, Zhejiang, China. Electronic address: .
Chen X; Physical Medicine and Rehabilitation Center, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, No. 109, Xueyuanxi Road, Wenzhou, Zhejiang, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2021 Apr 01; Vol. 270, pp. 119033. Date of Electronic Publication: 2021 Jan 23.
Typ publikacji :
Journal Article
MeSH Terms :
Adaptor Proteins, Signal Transducing/*metabolism
Brain Ischemia/*metabolism
Calcium-Calmodulin-Dependent Protein Kinase Type 2/*biosynthesis
Neuronal Plasticity/*physiology
Physical Exertion/*physiology
Animals ; Brain/metabolism ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Dendrites/metabolism ; Exercise Test ; Infarction, Middle Cerebral Artery/metabolism ; Ischemia/metabolism ; Ischemia/therapy ; Male ; Mice ; Mice, Inbred C57BL ; Physical Conditioning, Animal/physiology ; Signal Transduction ; Stroke/metabolism ; Stroke/therapy
Czasopismo naukowe
Tytuł :
Antagonistic control of myofiber size and muscle protein quality control by the ubiquitin ligase UBR4 during aging.
Autorzy :
Hunt LC; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Schadeberg B; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Stover J; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Haugen B; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Pagala V; Department of Structural Biology, Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Wang YD; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Puglise J; College of Health & Human Performance Applied Physiology & Kinesiology, University of Florida, Gainesville, FL, USA.
Barton ER; College of Health & Human Performance Applied Physiology & Kinesiology, University of Florida, Gainesville, FL, USA.
Peng J; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA.; Department of Structural Biology, Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN, USA.
Demontis F; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA. .
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Źródło :
Nature communications [Nat Commun] 2021 Mar 03; Vol. 12 (1), pp. 1418. Date of Electronic Publication: 2021 Mar 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Aging/*physiology
Calmodulin-Binding Proteins/*metabolism
Drosophila Proteins/*metabolism
Muscle Fibers, Skeletal/*physiology
Muscle Proteins/*metabolism
Ubiquitin-Protein Ligases/*metabolism
Animals ; Animals, Genetically Modified ; Autophagy/physiology ; Calmodulin-Binding Proteins/genetics ; Drosophila Proteins/genetics ; Female ; Lysosomes/metabolism ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Muscle Fibers, Skeletal/metabolism ; Muscle, Skeletal/pathology ; Muscle, Skeletal/physiology ; Proteolysis ; Ubiquitin/metabolism ; Ubiquitin-Protein Ligases/genetics
Czasopismo naukowe
Tytuł :
Targeting CALM2 Inhibits Hepatocellular Carcinoma Growth and Metastasis by Suppressing E2F5-mediated Cell Cycle Progression.
Autorzy :
Park SY; Department of Molecular Medicine, Keimyung University School of Medicine, Daegu, Republic of Korea.
Seo YR; Department of Molecular Medicine, Keimyung University School of Medicine, Daegu, Republic of Korea.
Ko MJ; Department of Molecular Medicine, Keimyung University School of Medicine, Daegu, Republic of Korea.
Lee JH; Department of Anatomy, Keimyung University School of Medicine, Daegu, Republic of Korea.
Chun KS; College of Pharmacy, Keimyung University, Daegu, Republic of Korea.
Kim MJ; Department of Molecular Medicine, Keimyung University School of Medicine, Daegu, Republic of Korea.
Choo YK; Department of Biological Science, College of Natural Sciences and Institute for Glycoscience, Wonkwang University, Iksan, Republic of Korea.
Lee TJ; Department of Anatomy, College of Medicine, Yeungnam University, Daegu, Republic of Korea.
Lee YH; Department of Molecular Medicine, Keimyung University School of Medicine, Daegu, Republic of Korea; .
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Źródło :
Anticancer research [Anticancer Res] 2021 Mar; Vol. 41 (3), pp. 1315-1325.
Typ publikacji :
Journal Article
MeSH Terms :
Calmodulin/*physiology
Carcinoma, Hepatocellular/*pathology
E2F5 Transcription Factor/*physiology
Liver Neoplasms/*pathology
Apoptosis/drug effects ; Calmodulin/antagonists & inhibitors ; Cell Cycle ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Humans ; Neoplasm Metastasis ; Neoplastic Stem Cells/physiology
Czasopismo naukowe
Tytuł :
Control of Allosteric Protein Electrochemical Switches with Biomolecular and Electronic Signals.
Autorzy :
Bollella P; Department of Chemistry and Biomolecular Science, Clarkson University, 8 Clarkson Avenue, Potsdam, New York 13699, United States.
Edwardraja S; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia.
Guo Z; CSIRO-QUT Synthetic Biology Alliance, ARC Centre of Excellence in Synthetic Biology, Centre for Agriculture and the Bioeconomy, Institute of Health and Biomedical Innovation, School of Biology and Environmental Science, Queensland University of Technology, Brisbane, QLD 4001, Australia.
Kirill Alexandrov; CSIRO-QUT Synthetic Biology Alliance, Centre for Tropical Crops and Biocommodities, Queensland University of Technology, Brisbane, QLD 4001, Australia.
Katz E; Department of Chemistry and Biomolecular Science, Clarkson University, 8 Clarkson Avenue, Potsdam, New York 13699, United States.
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Źródło :
The journal of physical chemistry letters [J Phys Chem Lett] 2020 Jul 16; Vol. 11 (14), pp. 5549-5554. Date of Electronic Publication: 2020 Jun 30.
Typ publikacji :
Journal Article
MeSH Terms :
Calmodulin/*metabolism
Glucose Dehydrogenases/*metabolism
Recombinant Fusion Proteins/*metabolism
Allosteric Regulation ; Calcium/metabolism ; Calmodulin/chemistry ; Calmodulin/genetics ; Calmodulin-Binding Proteins/metabolism ; Electrochemical Techniques/instrumentation ; Electrodes ; Enzymes, Immobilized/chemistry ; Enzymes, Immobilized/metabolism ; Glucose/chemistry ; Glucose Dehydrogenases/chemistry ; Mutation ; Oxidation-Reduction ; Protein Binding ; Recombinant Fusion Proteins/chemistry
Czasopismo naukowe
Tytuł :
Functional analysis of an R311C variant of Ca -calmodulin-dependent protein kinase kinase-2 (CaMKK2) found as a de novo mutation in a patient with bipolar disorder.
Autorzy :
Xy Ling N; St Vincent's Institute and Department of Medicine, The University of Melbourne, Fitzroy, Australia.
Langendorf CG; St Vincent's Institute and Department of Medicine, The University of Melbourne, Fitzroy, Australia.
Hoque A; St Vincent's Institute and Department of Medicine, The University of Melbourne, Fitzroy, Australia.
Galic S; St Vincent's Institute and Department of Medicine, The University of Melbourne, Fitzroy, Australia.
Loh K; St Vincent's Institute and Department of Medicine, The University of Melbourne, Fitzroy, Australia.
Kemp BE; St Vincent's Institute and Department of Medicine, The University of Melbourne, Fitzroy, Australia.; Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia.
Gundlach AL; The Florey Institute of Neuroscience and Mental Health, Parkville, Australia.
Oakhill JS; St Vincent's Institute and Department of Medicine, The University of Melbourne, Fitzroy, Australia.; Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia.
Scott JW; St Vincent's Institute and Department of Medicine, The University of Melbourne, Fitzroy, Australia.; Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia.; The Florey Institute of Neuroscience and Mental Health, Parkville, Australia.
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Źródło :
Bipolar disorders [Bipolar Disord] 2020 Dec; Vol. 22 (8), pp. 841-848. Date of Electronic Publication: 2020 Apr 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bipolar Disorder/*genetics
Calcium/*metabolism
Calcium-Calmodulin-Dependent Protein Kinase Kinase/*genetics
Calmodulin/*metabolism
Bipolar Disorder/diagnosis ; Calcium-Calmodulin-Dependent Protein Kinase Kinase/metabolism ; Calmodulin/genetics ; Genetic Variation ; Humans ; Mutation ; Phosphorylation ; Signal Transduction/physiology
Czasopismo naukowe
Tytuł :
Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation.
Autorzy :
Bhattacharyya M; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, United States.; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, United States.
Lee YK; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, United States.; Department of Chemistry, University of California, Berkeley, Berkeley, United States.
Muratcioglu S; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, United States.; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, United States.
Qiu B; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, United States.; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, United States.
Nyayapati P; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, United States.; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, United States.
Schulman H; Panorama Institute of Molecular Medicine, Sunnyvale, United States.
Groves JT; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, United States.; Department of Chemistry, University of California, Berkeley, Berkeley, United States.; Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, Berkeley, United States.
Kuriyan J; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States.; California Institute for Quantitative Biosciences (QB3), University of California, Berkeley, Berkeley, United States.; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, United States.; Department of Chemistry, University of California, Berkeley, Berkeley, United States.; Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, Berkeley, United States.
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Źródło :
ELife [Elife] 2020 Mar 09; Vol. 9. Date of Electronic Publication: 2020 Mar 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium-Calmodulin-Dependent Protein Kinase Type 2/*chemistry
Calcium-Calmodulin-Dependent Protein Kinase Type 2/*metabolism
Calcium/metabolism ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/antagonists & inhibitors ; Calmodulin/metabolism ; Catalytic Domain ; Enzyme Activation ; Humans ; Phosphorylation ; Protein Isoforms ; Single Molecule Imaging
Czasopismo naukowe
Tytuł :
Structure of a GRK5-Calmodulin Complex Reveals Molecular Mechanism of GRK Activation and Substrate Targeting.
Autorzy :
Komolov KE; Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Sulon SM; Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Bhardwaj A; Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
van Keulen SC; Department of Computer Science, Department of Molecular and Cellular Physiology, Department of Structural Biology, and Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA 94305, USA.
Duc NM; School of Pharmacy, Sungkyunkwan University, Suwon 16419, South Korea; Division of Precision Medicine, Research Institute, National Cancer Center, Goyang, South Korea.
Laurinavichyute DK; Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
Lou HJ; Department of Pharmacology, Yale School of Medicine, New Haven, CT 06520, USA.
Turk BE; Department of Pharmacology, Yale School of Medicine, New Haven, CT 06520, USA.
Chung KY; School of Pharmacy, Sungkyunkwan University, Suwon 16419, South Korea.
Dror RO; Department of Computer Science, Department of Molecular and Cellular Physiology, Department of Structural Biology, and Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA 94305, USA; Biophysics Program, Stanford University, Stanford, CA 94305, USA.
Benovic JL; Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2021 Jan 21; Vol. 81 (2), pp. 323-339.e11. Date of Electronic Publication: 2020 Dec 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium/*metabolism
Calmodulin/*chemistry
G-Protein-Coupled Receptor Kinase 5/*chemistry
Amino Acid Sequence ; Animals ; Baculoviridae/genetics ; Baculoviridae/metabolism ; Binding Sites ; Calmodulin/genetics ; Calmodulin/metabolism ; Cloning, Molecular ; Crystallography, X-Ray ; G-Protein-Coupled Receptor Kinase 5/genetics ; G-Protein-Coupled Receptor Kinase 5/metabolism ; Gene Expression ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; HEK293 Cells ; Humans ; Kinetics ; Molecular Dynamics Simulation ; Phosphorylation ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Sequence Alignment ; Sequence Homology, Amino Acid ; Sf9 Cells ; Spodoptera ; Substrate Specificity ; Thermodynamics
Czasopismo naukowe
Tytuł :
Gene therapy to inhibit CaMKII in CPVT.
Autorzy :
Lim GB; Nature Reviews Cardiology, . .
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Źródło :
Nature reviews. Cardiology [Nat Rev Cardiol] 2019 Aug; Vol. 16 (8), pp. 456.
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Calcium-Calmodulin-Dependent Protein Kinase Type 2*
Tachycardia, Ventricular*
Calcium ; Calmodulin ; Genetic Therapy ; Humans
SCR Disease Name :
Polymorphic catecholergic ventricular tachycardia
Czasopismo naukowe
Tytuł :
CaMKIIα-Positive Interneurons Identified via a microRNA-Based Viral Gene Targeting Strategy.
Autorzy :
Keaveney MK; Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215.
Rahsepar B; Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215.
Tseng HA; Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215.
Fernandez FR; Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215.
Mount RA; Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215.
Ta T; Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215.
White JA; Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215.
Berg J; Allen Institute for Brain Science, Seattle, Washington 98109.
Han X; Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215 .
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2020 Dec 09; Vol. 40 (50), pp. 9576-9588. Date of Electronic Publication: 2020 Nov 06.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Gene Targeting*
Calcium-Calmodulin-Dependent Protein Kinase Type 2/*genetics
Interneurons/*metabolism
MicroRNAs/*genetics
Motor Cortex/*metabolism
Animals ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Female ; Genetic Vectors ; Male ; Mice ; MicroRNAs/metabolism
Czasopismo naukowe
Tytuł :
Glu of α-Calcium/calmodulin dependent protein kinase II mediates crosstalk between the regulatory T-site and protein substrate binding region of the active site.
Autorzy :
Madhavan M; Molecular Neurobiology Division, Rajiv Gandhi Centre For Biotechnology, Thycaud, P. O., Thiruvananthapuram, 695014, India; Research scholar, University of Kerala, India.
Mohanan AG; Molecular Neurobiology Division, Rajiv Gandhi Centre For Biotechnology, Thycaud, P. O., Thiruvananthapuram, 695014, India; Research scholar, University of Kerala, India.
Jacob RS; Molecular Neurobiology Division, Rajiv Gandhi Centre For Biotechnology, Thycaud, P. O., Thiruvananthapuram, 695014, India; Research scholar, Manipal Academy of Higher Education, Manipal, 576 104, India.
Gunasekaran S; Molecular Neurobiology Division, Rajiv Gandhi Centre For Biotechnology, Thycaud, P. O., Thiruvananthapuram, 695014, India; Research scholar, Manipal Academy of Higher Education, Manipal, 576 104, India.
Nair RR; Molecular Neurobiology Division, Rajiv Gandhi Centre For Biotechnology, Thycaud, P. O., Thiruvananthapuram, 695014, India; Research scholar, University of Kerala, India.
Omkumar RV; Molecular Neurobiology Division, Rajiv Gandhi Centre For Biotechnology, Thycaud, P. O., Thiruvananthapuram, 695014, India. Electronic address: .
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Źródło :
Archives of biochemistry and biophysics [Arch Biochem Biophys] 2020 May 30; Vol. 685, pp. 108348. Date of Electronic Publication: 2020 Mar 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium-Calmodulin-Dependent Protein Kinase Type 2/*metabolism
Glutamic Acid/*chemistry
Receptors, N-Methyl-D-Aspartate/*metabolism
Calcium-Calmodulin-Dependent Protein Kinase Type 2/chemistry ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/genetics ; Calmodulin/metabolism ; Catalytic Domain ; HEK293 Cells ; Humans ; Kinetics ; Mutation ; Protein Binding
Czasopismo naukowe
Tytuł :
Comparison of Effects of Spatial and Non-Spatial Memory Acquisition on the CaMKII Pathway During Hypothyroidism and Nicotine Treatment.
Autorzy :
Alkadhi KA; Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, 77204-5515, USA. .
Alzoubi KH; Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan.
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Źródło :
Molecular neurobiology [Mol Neurobiol] 2020 Apr; Vol. 57 (4), pp. 1930-1937. Date of Electronic Publication: 2020 Jan 03.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Signal Transduction*/drug effects
Calcium-Calmodulin-Dependent Protein Kinase Type 2/*metabolism
Hypothyroidism/*metabolism
Hypothyroidism/*physiopathology
Nicotine/*pharmacology
Spatial Memory/*drug effects
Animals ; Calcineurin/metabolism ; Calmodulin/metabolism ; Hippocampus/drug effects ; Hippocampus/metabolism ; Hippocampus/pathology ; Hippocampus/physiopathology ; Male ; Morris Water Maze Test ; Protein Kinase C/metabolism ; Rats, Wistar ; Task Performance and Analysis
Czasopismo naukowe
Tytuł :
CaM Kinase II-δ Is Required for Diabetic Hyperglycemia and Retinopathy but Not Nephropathy.
Autorzy :
Chen J; Institute of Experimental Cardiology, Heidelberg University, Heidelberg, Germany.; German Center for Cardiovascular Research (partner site Heidelberg/Mannheim), Heidelberg, Germany.
Fleming T; Department of Internal Medicine I and Clinical Chemistry, University Hospital of Heidelberg, Heidelberg, Germany.
Katz S; Institute of Experimental Cardiology, Heidelberg University, Heidelberg, Germany.; German Center for Cardiovascular Research (partner site Heidelberg/Mannheim), Heidelberg, Germany.
Dewenter M; Institute of Experimental Cardiology, Heidelberg University, Heidelberg, Germany.; German Center for Cardiovascular Research (partner site Heidelberg/Mannheim), Heidelberg, Germany.
Hofmann K; Institute of Experimental Cardiology, Heidelberg University, Heidelberg, Germany.; German Center for Cardiovascular Research (partner site Heidelberg/Mannheim), Heidelberg, Germany.
Saadatmand A; Institute of Experimental Cardiology, Heidelberg University, Heidelberg, Germany.; German Center for Cardiovascular Research (partner site Heidelberg/Mannheim), Heidelberg, Germany.
Kronlage M; Institute of Experimental Cardiology, Heidelberg University, Heidelberg, Germany.; German Center for Cardiovascular Research (partner site Heidelberg/Mannheim), Heidelberg, Germany.; Department of Cardiology, University of Heidelberg, Heidelberg, Germany.
Werner MP; Institute of Experimental Cardiology, Heidelberg University, Heidelberg, Germany.; German Center for Cardiovascular Research (partner site Heidelberg/Mannheim), Heidelberg, Germany.
Pokrandt B; Heidelberg University Biochemistry Center, INF 328, Heidelberg, Germany.
Schreiter F; Institute of Experimental Cardiology, Heidelberg University, Heidelberg, Germany.; German Center for Cardiovascular Research (partner site Heidelberg/Mannheim), Heidelberg, Germany.
Lin J; 5th Medical Department, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Katz D; Institute of Experimental Cardiology, Heidelberg University, Heidelberg, Germany.; German Center for Cardiovascular Research (partner site Heidelberg/Mannheim), Heidelberg, Germany.
Morgenstern J; Department of Internal Medicine I and Clinical Chemistry, University Hospital of Heidelberg, Heidelberg, Germany.
Elwakiel A; Institute of Laboratory Medicine, Clinical Chemistry, and Molecular Diagnostics (ILM), University of Leipzig, Leipzig, Germany.
Sinn P; Department of Pathology, Heidelberg University Hospital, Heidelberg, Germany.
Gröne HJ; Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany.; Institute of Pathology, University of Marburg, Marburg, Germany.
Hammes HP; 5th Medical Department, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
Nawroth PP; Department of Internal Medicine I and Clinical Chemistry, University Hospital of Heidelberg, Heidelberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute for Diabetes and Cancer (IDC) Helmholtz Center Munich, Neuherberg, Germany.; Joint Heidelberg-Institute for Diabetes and Cancer (IDC) Translational Diabetes Program, Neuherberg, Germany.
Isermann B; Institute of Laboratory Medicine, Clinical Chemistry, and Molecular Diagnostics (ILM), University of Leipzig, Leipzig, Germany.
Sticht C; Medical Research Center, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Brügger B; Heidelberg University Biochemistry Center, INF 328, Heidelberg, Germany.
Katus HA; German Center for Cardiovascular Research (partner site Heidelberg/Mannheim), Heidelberg, Germany.; Department of Cardiology, University of Heidelberg, Heidelberg, Germany.
Hagenmueller M; Institute of Experimental Cardiology, Heidelberg University, Heidelberg, Germany.; German Center for Cardiovascular Research (partner site Heidelberg/Mannheim), Heidelberg, Germany.
Backs J; Institute of Experimental Cardiology, Heidelberg University, Heidelberg, Germany .; German Center for Cardiovascular Research (partner site Heidelberg/Mannheim), Heidelberg, Germany.
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Źródło :
Diabetes [Diabetes] 2021 Feb; Vol. 70 (2), pp. 616-626. Date of Electronic Publication: 2020 Nov 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Calcium-Calmodulin-Dependent Protein Kinase Type 2/*metabolism
Diabetes Mellitus, Type 2/*metabolism
Diabetic Nephropathies/*metabolism
Diabetic Retinopathy/*metabolism
Hyperglycemia/*metabolism
Animals ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/genetics ; Diabetes Mellitus, Type 2/genetics ; Diabetic Nephropathies/genetics ; Diabetic Retinopathy/genetics ; Gene Expression ; Hyperglycemia/genetics ; Mice ; Mice, Knockout ; Receptors, Leptin/genetics ; Receptors, Leptin/metabolism
Czasopismo naukowe
Tytuł :
Role of γ-adducin in actin cytoskeleton rearrangements in podocyte pathophysiology.
Autorzy :
Gao W; Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China.; Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Liu Y; Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Fan L; Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Zheng B; Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Jefferson JR; Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Wang S; Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Zhang H; Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Fang X; Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Nguyen BV; Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Zhu T; Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China.
Roman RJ; Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
Fan F; Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi.
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Źródło :
American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2021 Jan 01; Vol. 320 (1), pp. F97-F113. Date of Electronic Publication: 2020 Dec 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Actin Cytoskeleton/*metabolism
Calmodulin-Binding Proteins/*metabolism
Hypertension/*metabolism
Podocytes/*metabolism
Proteinuria/*metabolism
Renal Insufficiency, Chronic/*metabolism
Actin Cytoskeleton/pathology ; Animals ; Arterial Pressure ; Calmodulin-Binding Proteins/genetics ; Cell Adhesion ; Cell Line ; Cell Movement ; Cytoskeletal Proteins/genetics ; Cytoskeletal Proteins/metabolism ; Disease Models, Animal ; Disease Progression ; Focal Adhesions/metabolism ; Focal Adhesions/pathology ; Hypertension/genetics ; Hypertension/pathology ; Hypertension/physiopathology ; Integrins/metabolism ; Male ; Mice ; Monomeric GTP-Binding Proteins/metabolism ; Podocytes/pathology ; Proteinuria/genetics ; Proteinuria/pathology ; Proteinuria/physiopathology ; Rats, Inbred Strains ; Rats, Transgenic ; Renal Insufficiency, Chronic/genetics ; Renal Insufficiency, Chronic/pathology ; Renal Insufficiency, Chronic/physiopathology ; Signal Transduction
Czasopismo naukowe
Tytuł :
Millisecond Time-Resolved Solid-State NMR Reveals a Two-Stage Molecular Mechanism for Formation of Complexes between Calmodulin and a Target Peptide from Myosin Light Chain Kinase.
Autorzy :
Jeon J; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0520, United States.
Yau WM; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0520, United States.
Tycko R; Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892-0520, United States.
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Źródło :
Journal of the American Chemical Society [J Am Chem Soc] 2020 Dec 16; Vol. 142 (50), pp. 21220-21232. Date of Electronic Publication: 2020 Dec 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Nuclear Magnetic Resonance, Biomolecular*
Calmodulin/*metabolism
Myosin-Light-Chain Kinase/*chemistry
Peptide Fragments/*metabolism
Calmodulin/chemistry ; Kinetics ; Molecular Docking Simulation ; Peptide Fragments/chemistry ; Protein Domains
Czasopismo naukowe
Tytuł :
Arabidopsis calcium-dependent protein kinase 3 regulates actin cytoskeleton organization and immunity.
Autorzy :
Lu YJ; Department of Plant, Soil and Microbial Sciences, Michigan State University, East Lansing, MI, 48824, USA.
Li P; Department of Plant, Soil and Microbial Sciences, Michigan State University, East Lansing, MI, 48824, USA.; Department of Plant Biology, Michigan State University, East Lansing, MI, 48824, USA.
Shimono M; Department of Plant, Soil and Microbial Sciences, Michigan State University, East Lansing, MI, 48824, USA.
Corrion A; Department of Plant, Soil and Microbial Sciences, Michigan State University, East Lansing, MI, 48824, USA.
Higaki T; International Research Organization for Advanced Science and Technology (IROAST), Kumamoto University, Kumamoto, 860-8555, Japan.
He SY; Department of Plant, Soil and Microbial Sciences, Michigan State University, East Lansing, MI, 48824, USA.; Department of Plant Biology, Michigan State University, East Lansing, MI, 48824, USA.; Department of Energy Plant Research Laboratory, East Lansing, MI, 48824, USA.; Howard Hughes Medical Institute, Michigan State University, East Lansing, MI, 48824, USA.
Day B; Department of Plant, Soil and Microbial Sciences, Michigan State University, East Lansing, MI, 48824, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Dec 04; Vol. 11 (1), pp. 6234. Date of Electronic Publication: 2020 Dec 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Actin Cytoskeleton/*metabolism
Actin Depolymerizing Factors/*metabolism
Arabidopsis/*metabolism
Arabidopsis Proteins/*metabolism
Calcium-Calmodulin-Dependent Protein Kinases/*metabolism
Actin Depolymerizing Factors/genetics ; Amino Acid Sequence ; Arabidopsis/genetics ; Arabidopsis/microbiology ; Arabidopsis Proteins/genetics ; Calcium-Calmodulin-Dependent Protein Kinases/genetics ; Microscopy, Confocal ; Mutation ; Plant Diseases/microbiology ; Plant Immunity/genetics ; Plants, Genetically Modified ; Pseudomonas syringae/physiology ; Sequence Homology, Amino Acid
Czasopismo naukowe
Tytuł :
Calcium/Calmodulin-Dependent Kinase (CaMKII) Inhibition Protects Against Purkinje Cell Damage Following CA/CPR in Mice.
Autorzy :
Chalmers NE; Neuronal Injury Program, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.; Department of Anesthesiology, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Yonchek J; Neuronal Injury Program, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.; Department of Anesthesiology, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Steklac KE; Neuronal Injury Program, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Ramsey M; Neuronal Injury Program, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Bayer KU; Department of Pharmacology, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Herson PS; Neuronal Injury Program, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.; Department of Anesthesiology, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.; Department of Pharmacology, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Quillinan N; Neuronal Injury Program, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA. .; Department of Anesthesiology, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA. .
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Źródło :
Molecular neurobiology [Mol Neurobiol] 2020 Jan; Vol. 57 (1), pp. 150-158. Date of Electronic Publication: 2019 Sep 13.
Typ publikacji :
Journal Article
MeSH Terms :
Calcium/*metabolism
Calmodulin/*drug effects
Protective Agents/*pharmacology
Purkinje Cells/*drug effects
Animals ; Calcium Signaling/drug effects ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/drug effects ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Male ; Mice, Inbred C57BL ; Neurons/drug effects ; Neurons/metabolism ; Purkinje Cells/metabolism
Czasopismo naukowe

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