Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""Camptothecin"" wg kryterium: Temat


Tytuł :
Exposure-Response Relationships in Patients With HER2-Positive Metastatic Breast Cancer and Other Solid Tumors Treated With Trastuzumab Deruxtecan.
Autorzy :
Yin O; Daiichi Sankyo, Inc., Basking Ridge, New Jersey, USA.
Iwata H; Aichi Cancer Center, Nagoya, Japan.
Lin CC; National Taiwan University Hospital, Taipei, Taiwan.
Tamura K; National Cancer Center Japan, Tokyo, Japan.
Watanabe J; Shizuoka Cancer Center, Shizuoka, Japan.
Wada R; Certara USA, Inc., Princeton, New Jersey, USA.
Kastrissios H; Certara USA, Inc., Princeton, New Jersey, USA.
AbuTarif M; Daiichi Sankyo, Inc., Basking Ridge, New Jersey, USA.
Garimella T; Daiichi Sankyo, Inc., Basking Ridge, New Jersey, USA.
Lee C; Daiichi Sankyo, Inc., Basking Ridge, New Jersey, USA.
Zhang L; Daiichi Sankyo, Inc., Basking Ridge, New Jersey, USA.
Shahidi J; Daiichi Sankyo, Inc., Basking Ridge, New Jersey, USA.
LaCreta F; Daiichi Sankyo, Inc., Basking Ridge, New Jersey, USA.
Pokaż więcej
Źródło :
Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2021 Oct; Vol. 110 (4), pp. 986-996. Date of Electronic Publication: 2021 Jun 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adenocarcinoma/*drug therapy
Antineoplastic Agents/*administration & dosage
Breast Neoplasms/*drug therapy
Camptothecin/*analogs & derivatives
Immunoconjugates/*administration & dosage
Stomach Neoplasms/*drug therapy
Trastuzumab/*administration & dosage
Adenocarcinoma/metabolism ; Adenocarcinoma/secondary ; Antineoplastic Agents/pharmacokinetics ; Antineoplastic Agents/therapeutic use ; Area Under Curve ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Camptothecin/administration & dosage ; Camptothecin/pharmacokinetics ; Camptothecin/therapeutic use ; Clinical Trials as Topic ; Humans ; Immunoconjugates/pharmacokinetics ; Immunoconjugates/therapeutic use ; Kaplan-Meier Estimate ; Logistic Models ; Multivariate Analysis ; Proportional Hazards Models ; Receptor, ErbB-2/metabolism ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/pathology ; Trastuzumab/pharmacokinetics ; Trastuzumab/therapeutic use
Czasopismo naukowe
Tytuł :
Plant-microbe interactions implicated in the production of camptothecin - An anticancer biometabolite from Phyllosticta elongata MH458897 a novel endophytic strain isolated from medicinal plant of Western Ghats of India.
Autorzy :
Dhakshinamoorthy M; Endophytic Fungal Metabolite Research Laboratory, Bannari Amman Institute of Technology, Sathyamangalam, Erode District, Tamil Nadu, India. Electronic address: .
Ponnusamy SK; Department of Chemical Engineering, Sri Sivasubramaniya Nadar College of Engineering, Kalavakkam, Chennai, 603 110, India. Electronic address: .
Nyayiru Kannaian UP; Department of Biotechnology, School of Life Sciences, Vels University, Pallavaram, Chennai, TamilNadu, India. Electronic address: .
Srinivasan B; Department of Botany, Bharathi Women's College, Chennai, TamilNadu, India. Electronic address: .
Shankar SN; Marina Labs Research and Development, NT Patel Road, Nerkundram, Chennai, TamilNadu, India. Electronic address: .
Kilavan Packiam K; Endophytic Fungal Metabolite Research Laboratory, Bannari Amman Institute of Technology, Sathyamangalam, Erode District, Tamil Nadu, India. Electronic address: .
Pokaż więcej
Źródło :
Environmental research [Environ Res] 2021 Oct; Vol. 201, pp. 111564. Date of Electronic Publication: 2021 Jul 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Camptothecin*
Plants, Medicinal*
Ascomycota ; Ecosystem ; Humans ; India
SCR Organism :
Phyllosticta elongata
Czasopismo naukowe
Tytuł :
Antitumor Mechanism of Hydroxycamptothecin via the Metabolic Perturbation of Ribonucleotide and Deoxyribonucleotide in Human Colorectal Carcinoma Cells.
Autorzy :
Li Y; State Key Laboratory of Quality Research in Chinese Medicines, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau 999078, China.
Luo W; State Key Laboratory of Quality Research in Chinese Medicines, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau 999078, China.
Zhang H; State Key Laboratory of Quality Research in Chinese Medicines, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau 999078, China.
Wang C; State Key Laboratory of Quality Research in Chinese Medicines, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau 999078, China.
Yu C; Faculty of Agroforestry and Medicine, The Open University of China, Beijing 100039, China.
Jiang Z; State Key Laboratory of Quality Research in Chinese Medicines, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau 999078, China.
Zhang W; State Key Laboratory of Quality Research in Chinese Medicines, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Taipa, Macau 999078, China.
Pokaż więcej
Źródło :
Molecules (Basel, Switzerland) [Molecules] 2021 Aug 13; Vol. 26 (16). Date of Electronic Publication: 2021 Aug 13.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents, Phytogenic/*pharmacology
Camptothecin/*analogs & derivatives
Colorectal Neoplasms/*metabolism
DNA/*metabolism
Ribonucleotides/*metabolism
Camptothecin/pharmacology ; Cell Cycle Checkpoints/drug effects ; Cell Cycle Proteins/metabolism ; Cell Survival/drug effects ; DNA Damage ; HCT116 Cells ; Humans ; Irinotecan/pharmacology ; Ribonucleoside Diphosphate Reductase/metabolism ; Ribonucleotide Reductases/metabolism
Czasopismo naukowe
Tytuł :
A Randomized Phase II Trial of Adjuvant Hepatic Arterial Infusion and Systemic Therapy With or Without Panitumumab After Hepatic Resection of KRAS Wild-type Colorectal Cancer.
Autorzy :
Kemeny NE; Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
Chou JF; Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY.
Capanu M; Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY.
Chatila WK; Human Oncology & Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY.
Shi H; Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY.
Sanchez-Vega F; Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.; Computational Oncology Service, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY.
Kingham TP; Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
Connell LC; Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
Jarnagin WR; Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
D'Angelica MI; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY.
Pokaż więcej
Źródło :
Annals of surgery [Ann Surg] 2021 Aug 01; Vol. 274 (2), pp. 248-254.
Typ publikacji :
Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
Camptothecin/*analogs & derivatives
Colorectal Neoplasms/*drug therapy
Colorectal Neoplasms/*surgery
Panitumumab/*administration & dosage
Adult ; Aged ; Camptothecin/therapeutic use ; Chemotherapy, Adjuvant ; Female ; Floxuridine/administration & dosage ; Fluorouracil/therapeutic use ; Humans ; Infusions, Intra-Arterial ; Leucovorin/therapeutic use ; Male ; Middle Aged ; Proto-Oncogene Proteins p21(ras)
SCR Protocol :
IFL protocol
Czasopismo naukowe
Tytuł :
Berberine-10-hydroxy camptothecine-loaded lipid microsphere for the synergistic treatment of liver cancer by inhibiting topoisomerase and HIF-1α.
Autorzy :
Qi Y; Department of Pharmacy, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, P. R. China.
Liu G; Department of Pharmacy, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, P. R. China.
Pokaż więcej
Źródło :
Drug delivery [Drug Deliv] 2021 Dec; Vol. 28 (1), pp. 171-182.
Typ publikacji :
Journal Article
MeSH Terms :
Carcinoma, Hepatocellular*
Liver Neoplasms*
Microspheres*
Antineoplastic Agents, Phytogenic/*pharmacology
Berberine/*pharmacology
Camptothecin/*analogs & derivatives
Topoisomerase I Inhibitors/*pharmacology
Animals ; Antineoplastic Agents, Phytogenic/administration & dosage ; Antineoplastic Agents, Phytogenic/chemistry ; Berberine/administration & dosage ; Berberine/chemistry ; Camptothecin/administration & dosage ; Camptothecin/chemistry ; Camptothecin/pharmacology ; Cell Line, Tumor ; Drug Delivery Systems ; Drug Liberation ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/antagonists & inhibitors ; Mice ; Mice, Nude ; Rats ; Topoisomerase I Inhibitors/administration & dosage ; Topoisomerase I Inhibitors/chemistry ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
The biosynthesis of camptothecin derivatives by Camptotheca acuminata seedlings.
Autorzy :
Sun Y; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, Xi'an, China.
Zhang N; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, Xi'an, China.
Wang C; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, Xi'an, China.
Bai X; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, Xi'an, China.
Wei Y; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, Xi'an, China.
Liu J; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, Xi'an, China.
Pokaż więcej
Źródło :
Natural product research [Nat Prod Res] 2021 Jul; Vol. 35 (14), pp. 2403-2407. Date of Electronic Publication: 2019 Oct 21.
Typ publikacji :
Journal Article
MeSH Terms :
Camptotheca/*chemistry
Camptothecin/*analogs & derivatives
Camptothecin/*biosynthesis
Seedlings/*chemistry
Camptothecin/chemistry ; Hydrogen-Ion Concentration ; Plant Roots/chemistry
Czasopismo naukowe
Tytuł :
Current advances of endophytes as a platform for production of anti-cancer drug camptothecin.
Autorzy :
Ruan Q; Laboratory of Medicinal Plant Biotechnology, College of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, 310053, China. Electronic address: .
Patel G; Laboratory of Medicinal Plant Biotechnology, College of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, 310053, China. Electronic address: .
Wang J; Laboratory of Medicinal Plant Biotechnology, College of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, 310053, China. Electronic address: .
Luo E; Laboratory of Medicinal Plant Biotechnology, College of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, 310053, China. Electronic address: .
Zhou W; Laboratory of Medicinal Plant Biotechnology, College of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, 310053, China. Electronic address: .
Sieniawska E; Department of Pharmacognosy, Medical University of Lublin, Chodzki 1, 20-093, Lublin, Poland. Electronic address: .
Hao X; Laboratory of Medicinal Plant Biotechnology, College of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, 310053, China. Electronic address: .
Kai G; Laboratory of Medicinal Plant Biotechnology, College of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, 310053, China. Electronic address: .
Pokaż więcej
Źródło :
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2021 May; Vol. 151, pp. 112113. Date of Electronic Publication: 2021 Mar 16.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antineoplastic Agents, Phytogenic/*biosynthesis
Camptothecin/*biosynthesis
Endophytes/*metabolism
Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/pharmacology ; Bioreactors ; Camptothecin/chemistry ; Camptothecin/pharmacology ; Fermentation ; Gene Expression Regulation/drug effects ; Transcription, Genetic/drug effects
Czasopismo naukowe
Tytuł :
Distribution of camptothecin biosynthetic intermediates and identification the rate-limiting step of camptothecin biosynthesis.
Autorzy :
Sun Y; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, Xi'an, China.
Zhang N; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, Xi'an, China.
Wang C; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, Xi'an, China.
Wei Y; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, Xi'an, China.
Liu J; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Science, Northwest University, Xi'an, China.
Pokaż więcej
Źródło :
Natural product research [Nat Prod Res] 2021 Jul; Vol. 35 (13), pp. 2170-2177. Date of Electronic Publication: 2019 Sep 19.
Typ publikacji :
Journal Article
MeSH Terms :
Biosynthetic Pathways*
Camptothecin/*biosynthesis
Camptothecin/chemistry ; Chromatography, High Pressure Liquid ; Kinetics ; Reproducibility of Results
Czasopismo naukowe
Tytuł :
Risk-benefit Analysis of FOLFIRI Plus Ramucirumab/Aflibercept as a Third-line Treatment in Metastatic Colorectal Cancer.
Autorzy :
Kimura M; Department of Pharmacy, Ogaki Municipal Hospital, Gifu, Japan; .
Usami E; Department of Pharmacy, Ogaki Municipal Hospital, Gifu, Japan.
Teramachi H; Laboratory of Clinical Pharmacy, Gifu Pharmaceutical University, Gifu, Japan.
Yoshimura T; Department of Pharmacy, Ogaki Municipal Hospital, Gifu, Japan.
Pokaż więcej
Źródło :
Anticancer research [Anticancer Res] 2021 Jun; Vol. 41 (6), pp. 3091-3097.
Typ publikacji :
Journal Article
MeSH Terms :
Antibodies, Monoclonal, Humanized/*administration & dosage
Antineoplastic Combined Chemotherapy Protocols/*administration & dosage
Camptothecin/*analogs & derivatives
Colorectal Neoplasms/*drug therapy
Receptors, Vascular Endothelial Growth Factor/*administration & dosage
Recombinant Fusion Proteins/*administration & dosage
Adult ; Aged ; Antibodies, Monoclonal, Humanized/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Camptothecin/administration & dosage ; Camptothecin/adverse effects ; Colorectal Neoplasms/pathology ; Female ; Fluorouracil/administration & dosage ; Fluorouracil/adverse effects ; Humans ; Kaplan-Meier Estimate ; Leucovorin/administration & dosage ; Leucovorin/adverse effects ; Male ; Middle Aged ; Neoplasm Metastasis ; Recombinant Fusion Proteins/adverse effects
SCR Protocol :
IFL protocol
Czasopismo naukowe
Tytuł :
Trastuzumab deruxtecan (DS-8201) in patients with HER2-expressing metastatic colorectal cancer (DESTINY-CRC01): a multicentre, open-label, phase 2 trial.
Autorzy :
Siena S; Department of Oncology and Hemato-Oncology, Università degli Studi di Milano and Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Di Bartolomeo M; Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
Raghav K; The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Masuishi T; Aichi Cancer Center Hospital, Aichi, Japan.
Loupakis F; Oncology Institute Veneto IOV-IRCCS, Padua, Italy.
Kawakami H; Kindai University Hospital, Osaka, Japan.
Yamaguchi K; The Cancer Institute Hospital of JFCR, Tokyo, Japan.
Nishina T; National Hospital Organization Shikoku Cancer Center, Matsuyama, Japan.
Fakih M; City of Hope Medical Center, Philadelphia, PA, USA.
Elez E; Hospital Universitari Vall d'Hebron, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.
Rodriguez J; Department of Medical Oncology, Gastrointestinal Oncology Unit, Clínica Universidad de Navarra, University of Navarra, Navarra, Spain.
Ciardiello F; Università degli Studi della Campania Luigi Vanvitelli, Caserta, Italy.
Komatsu Y; Hokkaido University Hospital, Hokkaido, Japan.
Esaki T; National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan.
Chung K; Prisma Health Cancer Institute, Greenville, SC, USA.
Wainberg Z; UCLA Medical Center, Los Angeles, CA, USA.
Sartore-Bianchi A; Department of Oncology and Hemato-Oncology, Università degli Studi di Milano and Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy.
Saxena K; Daiichi Sankyo, Basking Ridge, NJ, USA.
Yamamoto E; Daiichi Sankyo Co, Ltd, Tokyo, Japan.
Bako E; Daiichi Sankyo, Basking Ridge, NJ, USA.
Okuda Y; Daiichi Sankyo Co, Ltd, Tokyo, Japan.
Shahidi J; Daiichi Sankyo, Basking Ridge, NJ, USA.
Grothey A; West Cancer Center, Germantown, TN, USA.
Yoshino T; National Cancer Center Hospital East, Kashiwa, Japan. Electronic address: .
Pokaż więcej
Corporate Authors :
DESTINY-CRC01 investigators
Źródło :
The Lancet. Oncology [Lancet Oncol] 2021 Jun; Vol. 22 (6), pp. 779-789. Date of Electronic Publication: 2021 May 04.
Typ publikacji :
Clinical Trial, Phase II; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies, Monoclonal, Humanized/*administration & dosage
Camptothecin/*analogs & derivatives
Colorectal Neoplasms/*drug therapy
Immunoconjugates/*administration & dosage
Receptor, ErbB-2/*genetics
Trastuzumab/*administration & dosage
Adult ; Aged ; Antibodies, Monoclonal, Humanized/adverse effects ; Camptothecin/administration & dosage ; Camptothecin/adverse effects ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Female ; Humans ; Immunoconjugates/adverse effects ; Italy/epidemiology ; Japan/epidemiology ; Male ; Maximum Tolerated Dose ; Middle Aged ; Neoplasm Metastasis ; Spain/epidemiology ; Trastuzumab/adverse effects
Czasopismo naukowe
Tytuł :
Endophytic fungus Diaporthe caatingaensis MT192326 from Buchanania axillaris: An indicator to produce biocontrol agents in plant protection.
Autorzy :
Dhakshinamoorthy M; Endophytic Fungal Metabolite Research Laboratory, Department of Biotechnology, Bannari Amman Institute of Technology, Sathyamangalam, Erode District, Tamil Nadu, India.
Kilavan Packiam K; Endophytic Fungal Metabolite Research Laboratory, Department of Biotechnology, Bannari Amman Institute of Technology, Sathyamangalam, Erode District, Tamil Nadu, India. Electronic address: .
Kumar PS; Department of Chemical Engineering, Sri Sivasubramaniya Nadar College of Engineering, Kalavakkam, Chennai, 603 110, India.
Saravanakumar T; Department of Biotechnology, Bannari Amman Institute of Technology, Sathyamangalam, Erode District, Tamil Nadu, India.
Pokaż więcej
Źródło :
Environmental research [Environ Res] 2021 Jun; Vol. 197, pp. 111147. Date of Electronic Publication: 2021 Apr 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Camptothecin*
Endophytes*
Ascomycota ; Fungi ; India
SCR Organism :
Diaporthe caatingaensis
Czasopismo naukowe
Tytuł :
Growth inhibition of Spodoptera frugiperda larvae by camptothecin correlates with alteration of the structures and gene expression profiles of the midgut.
Autorzy :
Shu B; Guangzhou City Key Laboratory of Subtropical Fruit Trees Outbreak Control, Institute for Management of Invasive Alien Species, Zhongkai University of Agriculture and Engineering, 313 Yingdong teaching building, 510225, Guangzhou, PR China.
Zou Y; Guangzhou City Key Laboratory of Subtropical Fruit Trees Outbreak Control, Institute for Management of Invasive Alien Species, Zhongkai University of Agriculture and Engineering, 313 Yingdong teaching building, 510225, Guangzhou, PR China.
Yu H; Guangzhou City Key Laboratory of Subtropical Fruit Trees Outbreak Control, Institute for Management of Invasive Alien Species, Zhongkai University of Agriculture and Engineering, 313 Yingdong teaching building, 510225, Guangzhou, PR China.
Zhang W; Guangzhou City Key Laboratory of Subtropical Fruit Trees Outbreak Control, Institute for Management of Invasive Alien Species, Zhongkai University of Agriculture and Engineering, 313 Yingdong teaching building, 510225, Guangzhou, PR China.
Li X; Guangzhou City Key Laboratory of Subtropical Fruit Trees Outbreak Control, Institute for Management of Invasive Alien Species, Zhongkai University of Agriculture and Engineering, 313 Yingdong teaching building, 510225, Guangzhou, PR China.
Cao L; Guangzhou City Key Laboratory of Subtropical Fruit Trees Outbreak Control, Institute for Management of Invasive Alien Species, Zhongkai University of Agriculture and Engineering, 313 Yingdong teaching building, 510225, Guangzhou, PR China.
Lin J; Guangzhou City Key Laboratory of Subtropical Fruit Trees Outbreak Control, Institute for Management of Invasive Alien Species, Zhongkai University of Agriculture and Engineering, 313 Yingdong teaching building, 510225, Guangzhou, PR China. .
Pokaż więcej
Źródło :
BMC genomics [BMC Genomics] 2021 May 26; Vol. 22 (1), pp. 391. Date of Electronic Publication: 2021 May 26.
Typ publikacji :
Journal Article
MeSH Terms :
Camptothecin*/pharmacology
Transcriptome*
Animals ; Digestive System ; Larva/genetics ; Spodoptera/genetics
Czasopismo naukowe
Tytuł :
Population Pharmacokinetics of Trastuzumab Deruxtecan in Patients With HER2-Positive Breast Cancer and Other Solid Tumors.
Autorzy :
Yin O; Quantitative Clinical Pharmacology and Translational Sciences, Daiichi Sankyo, Inc, Basking Ridge, New Jersey, USA.
Xiong Y; Certara Strategic Consulting, Princeton, New Jersey, USA.
Endo S; Clinical Pharmacology Department, Daiichi Sankyo Co, Ltd, Tokyo, Japan.
Yoshihara K; Clinical Pharmacology Department, Daiichi Sankyo Co, Ltd, Tokyo, Japan.
Garimella T; Quantitative Clinical Pharmacology and Translational Sciences, Daiichi Sankyo, Inc, Basking Ridge, New Jersey, USA.
AbuTarif M; Quantitative Clinical Pharmacology and Translational Sciences, Daiichi Sankyo, Inc, Basking Ridge, New Jersey, USA.
Wada R; Certara Strategic Consulting, Princeton, New Jersey, USA.
LaCreta F; Quantitative Clinical Pharmacology and Translational Sciences, Daiichi Sankyo, Inc, Basking Ridge, New Jersey, USA.
Pokaż więcej
Źródło :
Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2021 May; Vol. 109 (5), pp. 1314-1325. Date of Electronic Publication: 2020 Dec 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Breast Neoplasms/*drug therapy
Camptothecin/*analogs & derivatives
Immunoconjugates/*pharmacokinetics
Trastuzumab/*pharmacokinetics
Age Factors ; Antineoplastic Agents, Immunological/pharmacokinetics ; Body Weight ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Camptothecin/blood ; Camptothecin/pharmacokinetics ; Drug Liberation ; Female ; Humans ; Immunoconjugates/blood ; Male ; Models, Biological ; Receptor, ErbB-2/metabolism ; Trastuzumab/blood
Czasopismo naukowe
Tytuł :
Improving stability and oral bioavailability of hydroxycamptothecin via nanocrystals in microparticles (NCs/MPs) technology.
Autorzy :
Wang Y; School of Pharmacy, Shanghai University of Medicine & Health Sciences, Shanghai 201318, China.
Xuan J; School of Pharmacy, Shanghai University of Medicine & Health Sciences, Shanghai 201318, China.
Zhao G; School of Pharmacy, Shanghai University of Medicine & Health Sciences, Shanghai 201318, China.
Wang D; School of Pharmacy, Shanghai University of Medicine & Health Sciences, Shanghai 201318, China.
Ying N; School of Pharmacy, Shanghai University of Medicine & Health Sciences, Shanghai 201318, China.
Zhuang J; School of Pharmacy, Shanghai University of Medicine & Health Sciences, Shanghai 201318, China. Electronic address: .
Pokaż więcej
Źródło :
International journal of pharmaceutics [Int J Pharm] 2021 Jul 15; Vol. 604, pp. 120729. Date of Electronic Publication: 2021 May 23.
Typ publikacji :
Journal Article
MeSH Terms :
Camptothecin*/analogs & derivatives
Nanoparticles*
Animals ; Biological Availability ; Particle Size ; Rats ; Technology
Czasopismo naukowe
Tytuł :
Supramolecular Antagonists Promote Mitochondrial Dysfunction.
Autorzy :
Li M; Key Laboratory of Functional Polymer Materials, Ministry of Education, State Key Laboratory of Medicinal Chemical Biology, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Weijin Road 94, Tianjin 300071, China.
Song Y; Key Laboratory of Functional Polymer Materials, Ministry of Education, State Key Laboratory of Medicinal Chemical Biology, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Weijin Road 94, Tianjin 300071, China.
Song N; Key Laboratory of Functional Polymer Materials, Ministry of Education, State Key Laboratory of Medicinal Chemical Biology, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Weijin Road 94, Tianjin 300071, China.
Wu G; Key Laboratory of Functional Polymer Materials, Ministry of Education, State Key Laboratory of Medicinal Chemical Biology, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Weijin Road 94, Tianjin 300071, China.
Zhou H; Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Science, College of Life Sciences, Nankai University, Weijin Road 94, Tianjin 300071, China.
Long J; Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Science, College of Life Sciences, Nankai University, Weijin Road 94, Tianjin 300071, China.
Zhang P; State Key Laboratory of Drug Research & Center for Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, China.
Shi L; Key Laboratory of Functional Polymer Materials, Ministry of Education, State Key Laboratory of Medicinal Chemical Biology, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Weijin Road 94, Tianjin 300071, China.
Yu Z; Key Laboratory of Functional Polymer Materials, Ministry of Education, State Key Laboratory of Medicinal Chemical Biology, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Weijin Road 94, Tianjin 300071, China.
Pokaż więcej
Źródło :
Nano letters [Nano Lett] 2021 Jul 14; Vol. 21 (13), pp. 5730-5737. Date of Electronic Publication: 2021 Jun 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Camptothecin*/pharmacology
Mitochondria
Czasopismo naukowe
Tytuł :
[Chinese expert consensus on the clinical application of the Chinese modified triplet combination with irinotecan, oxaliplatin and continuous infusional 5-fluorouracil/leucovorin for colorectal cancer].
Corporate Authors :
Committee of Colorectal Cancer, Chinese Southern Oncology Group
Źródło :
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery [Zhonghua Wei Chang Wai Ke Za Zhi] 2021 Jun 25; Vol. 24 (6), pp. 473-479.
Typ publikacji :
Journal Article
MeSH Terms :
Camptothecin*/therapeutic use
Colorectal Neoplasms*/drug therapy
Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; China ; Consensus ; Fluorouracil/therapeutic use ; Humans ; Irinotecan/therapeutic use ; Leucovorin/therapeutic use ; Organoplatinum Compounds/therapeutic use ; Oxaliplatin ; Treatment Outcome
Czasopismo naukowe
Tytuł :
A chromosome-level Camptotheca acuminata genome assembly provides insights into the evolutionary origin of camptothecin biosynthesis.
Autorzy :
Kang M; Key Laboratory of Bio-resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.
Fu R; Key Laboratory of Bio-resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.
Zhang P; Key Laboratory of Bio-resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.
Lou S; Key Laboratory of Bio-resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.
Yang X; Key Laboratory of Bio-resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.
Chen Y; Key Laboratory of Bio-resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.
Ma T; Key Laboratory of Bio-resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.
Zhang Y; Key Laboratory of Bio-resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.
Xi Z; Key Laboratory of Bio-resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China.
Liu J; Key Laboratory of Bio-resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu, China. .
Pokaż więcej
Źródło :
Nature communications [Nat Commun] 2021 Jun 10; Vol. 12 (1), pp. 3531. Date of Electronic Publication: 2021 Jun 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Genome, Plant*
Camptotheca/*metabolism
Camptothecin/*metabolism
Chromosomes/*metabolism
Secondary Metabolism/*genetics
Camptotheca/enzymology ; Camptotheca/genetics ; Camptothecin/biosynthesis ; Chromosomes/genetics ; Cytochrome P-450 Enzyme System ; Evolution, Molecular ; Gene Expression Regulation, Plant/genetics ; Genes, Duplicate ; Genomics ; Iridoids/metabolism ; Oxidoreductases Acting on CH-CH Group Donors ; Phylogeny ; Protein O-Methyltransferase/genetics ; Protein O-Methyltransferase/metabolism ; RNA-Seq ; Vinblastine/metabolism
Czasopismo naukowe
Tytuł :
[FOLFIRI plus Ramucirumab Treatment for Metastatic Colorectal Cancer-Narrative Review of Real-World Evidence in Japan].
Autorzy :
Jin L; Eli Lilly Japan K.K., Medical Development Unit and Medical Affairs.
Tanizawa Y
Shinozaki E
Pokaż więcej
Źródło :
Gan to kagaku ryoho. Cancer & chemotherapy [Gan To Kagaku Ryoho] 2021 Jun; Vol. 48 (6), pp. 797-803.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Camptothecin*/therapeutic use
Colorectal Neoplasms*/drug therapy
Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Humanized ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Fluorouracil/therapeutic use ; Humans ; Japan ; Leucovorin/therapeutic use ; Neoplasm Metastasis
Czasopismo naukowe
Tytuł :
A novel GSH-triggered polymeric nanomicelles for reversing MDR and enhancing antitumor efficiency of hydroxycamptothecin.
Autorzy :
Zong L; Institute of Pharmacy, School of Pharmacy, Henan University, N. Jinming Ave., Kaifeng, Henan 475004, China.
Wang H; Institute of Pharmacy, School of Pharmacy, Henan University, N. Jinming Ave., Kaifeng, Henan 475004, China.
Hou X; Institute of Pharmacy, School of Pharmacy, Henan University, N. Jinming Ave., Kaifeng, Henan 475004, China.
Fu L; Institute of Pharmacy, School of Pharmacy, Henan University, N. Jinming Ave., Kaifeng, Henan 475004, China.
Wang P; Institute of Pharmacy, School of Pharmacy, Henan University, N. Jinming Ave., Kaifeng, Henan 475004, China.
Xu H; Institute of Pharmacy, School of Pharmacy, Henan University, N. Jinming Ave., Kaifeng, Henan 475004, China.
Yu W; Institute of Pharmacy, School of Pharmacy, Henan University, N. Jinming Ave., Kaifeng, Henan 475004, China.
Dai Y; Institute of Pharmacy, School of Pharmacy, Henan University, N. Jinming Ave., Kaifeng, Henan 475004, China.
Qiao Y; Henan University of Chinese Medicine, Zhengzhou, Henan 450046, China.
Wang X; Department of Obstetrics and Gynecology, the Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510632, China.
Yuan Q; Institute of Pharmacy, School of Pharmacy, Henan University, N. Jinming Ave., Kaifeng, Henan 475004, China.
Pang X; Institute of Pharmacy, School of Pharmacy, Henan University, N. Jinming Ave., Kaifeng, Henan 475004, China. Electronic address: .
Han G; Institute of Pharmacy, School of Pharmacy, Henan University, N. Jinming Ave., Kaifeng, Henan 475004, China. Electronic address: .
Pu X; Institute of Pharmacy, School of Pharmacy, Henan University, N. Jinming Ave., Kaifeng, Henan 475004, China. Electronic address: .
Pokaż więcej
Źródło :
International journal of pharmaceutics [Int J Pharm] 2021 May 01; Vol. 600, pp. 120528. Date of Electronic Publication: 2021 Mar 26.
Typ publikacji :
Journal Article
MeSH Terms :
Camptothecin*/analogs & derivatives
Micelles*
Animals ; Cell Line, Tumor ; Drug Delivery Systems ; Drug Resistance, Multiple ; Drug Resistance, Neoplasm ; Mice ; Polymers
Czasopismo naukowe
Tytuł :
Trastuzumab Deruxtecan: Changing the Destiny of HER2 Expressing Solid Tumors.
Autorzy :
Indini A; Medical Oncology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
Rijavec E; Medical Oncology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
Grossi F; Medical Oncology Unit, Department of Medicine and Surgery, University of Insubria, ASST dei Sette Laghi, 21100 Varese, Italy.
Pokaż więcej
Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 30; Vol. 22 (9). Date of Electronic Publication: 2021 Apr 30.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Antineoplastic Agents, Immunological/*therapeutic use
Camptothecin/*analogs & derivatives
Immunoconjugates/*therapeutic use
Neoplasms/*drug therapy
Receptor, ErbB-2/*analysis
Trastuzumab/*therapeutic use
Animals ; Antineoplastic Agents, Immunological/adverse effects ; Antineoplastic Agents, Immunological/pharmacology ; Camptothecin/adverse effects ; Camptothecin/pharmacology ; Camptothecin/therapeutic use ; Clinical Trials as Topic ; Humans ; Immunoconjugates/adverse effects ; Immunoconjugates/pharmacology ; Neoplasms/pathology ; Trastuzumab/adverse effects ; Trastuzumab/pharmacology
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies