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Tytuł :
Pyridoxine induces monocyte-macrophages death as specific treatment of acute myeloid leukemia.
Autorzy :
Yang W; The Second Affiliated Hospital, The State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology, Guangzhou Medical University, Guangzhou, 510260, PR China.
Liu S; The Second Affiliated Hospital, The State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology, Guangzhou Medical University, Guangzhou, 510260, PR China.
Li Y; The Second Affiliated Hospital, The State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology, Guangzhou Medical University, Guangzhou, 510260, PR China.
Wang Y; School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, 510260, PR China.
Deng Y; The Second Affiliated Hospital, The State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology, Guangzhou Medical University, Guangzhou, 510260, PR China.
Sun W; The Second Affiliated Hospital, The State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology, Guangzhou Medical University, Guangzhou, 510260, PR China.
Huang H; The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510260, PR China.
Xie J; The Second Affiliated Hospital, The State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology, Guangzhou Medical University, Guangzhou, 510260, PR China.
He A; The Second Affiliated Hospital, The State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology, Guangzhou Medical University, Guangzhou, 510260, PR China.
Chen H; The Second Affiliated Hospital, The State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology, Guangzhou Medical University, Guangzhou, 510260, PR China.
Tao A; The Second Affiliated Hospital, The State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology, Guangzhou Medical University, Guangzhou, 510260, PR China. Electronic address: .
Yan J; The Second Affiliated Hospital, The State Key Laboratory of Respiratory Disease, Guangdong Provincial Key Laboratory of Allergy & Clinical Immunology, Guangzhou Medical University, Guangzhou, 510260, PR China. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2020 Nov 01; Vol. 492, pp. 96-105. Date of Electronic Publication: 2020 Aug 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*drug effects
Leukemia, Myeloid, Acute/*drug therapy
Macrophages/*drug effects
Monocytes/*drug effects
Pyridoxine/*pharmacology
Animals ; Cells, Cultured ; Humans ; Leukemia, Myeloid, Acute/pathology ; Macrophages/pathology ; Mice ; Mice, Inbred C57BL ; Monocytes/pathology ; Oligopeptides/pharmacology ; Pyridoxine/therapeutic use ; Pyroptosis/drug effects
Czasopismo naukowe
Tytuł :
The novel dual BET/HDAC inhibitor TW09 mediates cell death by mitochondrial apoptosis in rhabdomyosarcoma cells.
Autorzy :
Laszig S; Institute for Experimental Cancer Research in Pediatrics, Goethe-University Frankfurt, Komturstrasse 3a, 60528, Frankfurt, Germany.
Boedicker C; Institute for Experimental Cancer Research in Pediatrics, Goethe-University Frankfurt, Komturstrasse 3a, 60528, Frankfurt, Germany.
Weiser T; Institute for Pharmaceutical Chemistry, Goethe-University and Buchmann Institute for Molecular Life Sciences (BMLS), Frankfurt, Germany.
Knapp S; German Cancer Consortium (DKTK), Partner Site Frankfurt, Germany; Institute for Pharmaceutical Chemistry, Goethe-University and Buchmann Institute for Molecular Life Sciences (BMLS), Frankfurt, Germany.
Fulda S; Institute for Experimental Cancer Research in Pediatrics, Goethe-University Frankfurt, Komturstrasse 3a, 60528, Frankfurt, Germany; German Cancer Consortium (DKTK), Partner Site Frankfurt, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2020 Aug 28; Vol. 486, pp. 46-57. Date of Electronic Publication: 2020 May 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Histone Deacetylase Inhibitors/*pharmacology
Mitochondria/*drug effects
Proteins/*antagonists & inhibitors
Rhabdomyosarcoma/*drug therapy
Caspases/physiology ; Cell Line, Tumor ; Humans ; Membrane Potential, Mitochondrial/drug effects ; Proto-Oncogene Proteins c-bcl-2/physiology ; Rhabdomyosarcoma/pathology ; bcl-2-Associated X Protein/physiology
Czasopismo naukowe
Tytuł :
The p14ARF tumor suppressor restrains androgen receptor activity and prevents apoptosis in prostate cancer cells.
Autorzy :
Siddiqui S; Veterans Affairs-Northern California Health Care System, Mather, CA, USA.
Libertini SJ; Veterans Affairs-Northern California Health Care System, Mather, CA, USA; Department of Medical Microbiology and Immunology, USA.
Lucas CA; Veterans Affairs-Northern California Health Care System, Mather, CA, USA; Department of Medical Microbiology and Immunology, USA.
Lombard AP; Veterans Affairs-Northern California Health Care System, Mather, CA, USA; Department of Medical Microbiology and Immunology, USA.
Baek HB; Veterans Affairs-Northern California Health Care System, Mather, CA, USA; Department of Medical Microbiology and Immunology, USA.
Nakagawa RM; Department of Medical Microbiology and Immunology, USA.
Nishida KS; Department of Medical Microbiology and Immunology, USA.
Steele TM; Veterans Affairs-Northern California Health Care System, Mather, CA, USA; Department of Urologic Surgery, USA.
Melgoza FU; Veterans Affairs-Northern California Health Care System, Mather, CA, USA.
Borowsky AD; Department of Pathology and Laboratory Medicine, USA.
Durbin-Johnson BP; Bioinformatics Core, USA.
Qi L; Department of Public Health Sciences, University of California Davis, California, USA.
Ghosh PM; Veterans Affairs-Northern California Health Care System, Mather, CA, USA; Department of Urologic Surgery, USA.
Mudryj M; Veterans Affairs-Northern California Health Care System, Mather, CA, USA; Department of Medical Microbiology and Immunology, USA. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2020 Jul 28; Vol. 483, pp. 12-21. Date of Electronic Publication: 2020 Apr 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Apoptosis*
Cyclin-Dependent Kinase Inhibitor p16/*metabolism
Prostatic Neoplasms/*metabolism
Receptors, Androgen/*metabolism
Tumor Suppressor Protein p14ARF/*metabolism
Adult ; Aged ; Animals ; Cell Line, Tumor ; Cyclin-Dependent Kinase Inhibitor p16/genetics ; E2F Transcription Factors/genetics ; E2F Transcription Factors/metabolism ; Gene Expression Regulation, Neoplastic ; Humans ; Kallikreins/genetics ; Kallikreins/metabolism ; Male ; Mice, Nude ; Middle Aged ; Prostate-Specific Antigen/genetics ; Prostate-Specific Antigen/metabolism ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/pathology ; Receptors, Androgen/genetics ; Serine Endopeptidases/genetics ; Serine Endopeptidases/metabolism ; Signal Transduction ; Tumor Suppressor Protein p14ARF/genetics
Czasopismo naukowe
Tytuł :
Overexpression of ubiquitin-conjugating enzyme E2 L3 in hepatocellular carcinoma potentiates apoptosis evasion by inhibiting the GSK3β/p65 pathway.
Autorzy :
Tao NN; Department of Infectious Disease, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders (Chongqing), China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China; Department of Clinical Laboratory, Chongqing Traditional Chinese Medicine Hospital, Chongqing, China.
Zhang ZZ; Department of Infectious Disease, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders (Chongqing), China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Ren JH; The Key Laboratory of Molecular Biology of Infectious Diseases Designated By the Chinese Ministry of Education, Chongqing Medical University, Chongqing, China.
Zhang J; Department of Clinical Laboratory, Chongqing Traditional Chinese Medicine Hospital, Chongqing, China.
Zhou YJ; The Key Laboratory of Molecular Biology of Infectious Diseases Designated By the Chinese Ministry of Education, Chongqing Medical University, Chongqing, China.
Wai Wong VK; State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China.
Kwan Law BY; State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China.
Cheng ST; The Key Laboratory of Molecular Biology of Infectious Diseases Designated By the Chinese Ministry of Education, Chongqing Medical University, Chongqing, China.
Zhou HZ; The Key Laboratory of Molecular Biology of Infectious Diseases Designated By the Chinese Ministry of Education, Chongqing Medical University, Chongqing, China.
Chen WX; Department of Clinical Laboratory, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Xu HM; Department of Infectious Disease, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders (Chongqing), China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China. Electronic address: .
Chen J; Department of Infectious Disease, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders (Chongqing), China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2020 Jul 01; Vol. 481, pp. 1-14. Date of Electronic Publication: 2020 Apr 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*genetics
Carcinoma, Hepatocellular/*genetics
Glycogen Synthase Kinase 3 beta/*genetics
Liver Neoplasms/*genetics
Signal Transduction/*genetics
Transcription Factor RelA/*genetics
Ubiquitin-Conjugating Enzymes/*genetics
Animals ; Carcinoma, Hepatocellular/pathology ; Cell Line, Tumor ; Cell Proliferation/genetics ; Humans ; Liver Neoplasms/pathology ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Phosphorylation/genetics ; Up-Regulation/genetics
Czasopismo naukowe
Tytuł :
SUV39H1 regulates human colon carcinoma apoptosis and cell cycle to promote tumor growth.
Autorzy :
Lu C; Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA, 30912, USA; Georgia Cancer Center, Medical College of Georgia, Augusta, GA, 30912, USA; Charlie Norwood VA Medical Center, Augusta, GA, 30904, USA. Electronic address: .
Klement JD; Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA, 30912, USA; Georgia Cancer Center, Medical College of Georgia, Augusta, GA, 30912, USA; Charlie Norwood VA Medical Center, Augusta, GA, 30904, USA.
Yang D; Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA, 30912, USA; Georgia Cancer Center, Medical College of Georgia, Augusta, GA, 30912, USA; Charlie Norwood VA Medical Center, Augusta, GA, 30904, USA.
Albers T; Georgia Cancer Center, Medical College of Georgia, Augusta, GA, 30912, USA.
Lebedyeva IO; Department of Chemistry and Physics, Augusta University, Augusta, GA, 30904, USA.
Waller JL; Department of Population Health Sciences, Augusta University, Augusta, GA, 30912, USA.
Liu K; Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA, 30912, USA; Georgia Cancer Center, Medical College of Georgia, Augusta, GA, 30912, USA; Charlie Norwood VA Medical Center, Augusta, GA, 30904, USA. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2020 Apr 28; Vol. 476, pp. 87-96. Date of Electronic Publication: 2020 Feb 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Apoptosis*
Cell Cycle Checkpoints*
Biomarkers, Tumor/*metabolism
Colonic Neoplasms/*pathology
Fas Ligand Protein/*metabolism
Methyltransferases/*metabolism
Repressor Proteins/*metabolism
Animals ; Antimetabolites, Antineoplastic/pharmacology ; Biomarkers, Tumor/genetics ; Cell Proliferation ; Colonic Neoplasms/drug therapy ; Colonic Neoplasms/genetics ; Colonic Neoplasms/metabolism ; Fas Ligand Protein/genetics ; Female ; Fluorouracil/pharmacology ; Gene Expression Regulation, Neoplastic ; Humans ; Methyltransferases/genetics ; Mice ; Mice, Nude ; Repressor Proteins/genetics ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Loss of hnRNPA2B1 inhibits malignant capability and promotes apoptosis via down-regulating Lin28B expression in ovarian cancer.
Autorzy :
Yang Y; Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120, China.
Wei Q; Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120, China.
Tang Y; Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120, China.
Yuanyuan Wang; Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China.
Luo Q; Department of Obstetrics and Gynecology, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, 401120, China.
Zhao H; Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120, China.
He M; Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120, China.
Wang H; Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120, China.
Zeng Q; Department of Obstetrics and Gynecology, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, 401120, China.
Lu W; Department of Obstetrics and Gynecology, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, 401120, China.
Xu J; Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120, China. Electronic address: .
Liu T; Department of Obstetrics and Gynecology, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, 401120, China. Electronic address: .
Yi P; Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120, China. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2020 Apr 10; Vol. 475, pp. 43-52. Date of Electronic Publication: 2020 Jan 29.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Gene Expression Regulation, Neoplastic*
Biomarkers, Tumor/*metabolism
Heterogeneous-Nuclear Ribonucleoprotein Group A-B/*metabolism
Ovarian Neoplasms/*pathology
RNA-Binding Proteins/*metabolism
Animals ; Biomarkers, Tumor/genetics ; Cell Movement ; Cell Proliferation ; Female ; Heterogeneous-Nuclear Ribonucleoprotein Group A-B/genetics ; Humans ; Mice ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/metabolism ; Prognosis ; RNA-Binding Proteins/genetics ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
The CCR5 antagonist maraviroc causes remission of pancreatic cancer liver metastasis in nude rats based on cell cycle inhibition and apoptosis induction.
Autorzy :
Huang H; Toxicology and Chemotherapy Unit (G401), German Cancer Research Center, 69120, Heidelberg, Germany.
Zepp M; Toxicology and Chemotherapy Unit (G401), German Cancer Research Center, 69120, Heidelberg, Germany.
Georges RB; Toxicology and Chemotherapy Unit (G401), German Cancer Research Center, 69120, Heidelberg, Germany.
Jarahian M; Toxicology and Chemotherapy Unit (G401), German Cancer Research Center, 69120, Heidelberg, Germany.
Kazemi M; Toxicology and Chemotherapy Unit (G401), German Cancer Research Center, 69120, Heidelberg, Germany.
Eyol E; Toxicology and Chemotherapy Unit (G401), German Cancer Research Center, 69120, Heidelberg, Germany.
Berger MR; Toxicology and Chemotherapy Unit (G401), German Cancer Research Center, 69120, Heidelberg, Germany. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2020 Apr 01; Vol. 474, pp. 82-93. Date of Electronic Publication: 2020 Jan 16.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*
Cell Cycle*
Carcinoma, Pancreatic Ductal/*drug therapy
Liver Neoplasms/*drug therapy
Maraviroc/*pharmacology
Pancreatic Neoplasms/*drug therapy
Receptors, CCR5/*chemistry
Animals ; CCR5 Receptor Antagonists/pharmacology ; Carcinoma, Pancreatic Ductal/metabolism ; Carcinoma, Pancreatic Ductal/pathology ; Cell Movement ; Cell Proliferation ; Humans ; Liver Neoplasms/metabolism ; Liver Neoplasms/secondary ; Male ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/pathology ; Rats ; Rats, Nude ; Receptors, CCR5/metabolism ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Cisplatin unleashes Toll-like receptor 3-mediated apoptosis through the downregulation of c-FLIP in malignant mesothelioma.
Autorzy :
Vanbervliet-Defrance B; Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Cancer Research Center of Lyon, Lyon, France.
Delaunay T; CRCINA, INSERM, Université D'Angers, Université de Nantes, Nantes, France; Labex IGO, Immunology Graft Oncology, Nantes, France.
Daunizeau T; Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Cancer Research Center of Lyon, Lyon, France.
Kepenekian V; Service de Chirurgie Viscérale et Oncologique, Hospices Civils de Lyon, Hôpital Lyon Sud, Lyon, France; Université de Lyon, Université Claude Bernard Lyon 1, EMR 3738, Oullins, France.
Glehen O; Service de Chirurgie Viscérale et Oncologique, Hospices Civils de Lyon, Hôpital Lyon Sud, Lyon, France; Université de Lyon, Université Claude Bernard Lyon 1, EMR 3738, Oullins, France.
Weber K; Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Cancer Research Center of Lyon, Lyon, France.
Estornes Y; Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Cancer Research Center of Lyon, Lyon, France.
Ziverec A; Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Cancer Research Center of Lyon, Lyon, France.
Djemal L; Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Cancer Research Center of Lyon, Lyon, France.
Delphin M; Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Cancer Research Center of Lyon, Lyon, France.
Lantuéjoul S; Department of Biopathology and Translation Research and Innovation, Centre Léon Bérard and Synergie Lyon Cancer, Lyrican, Lyon, and Grenoble Alpes University, France.
Passot G; Service de Chirurgie Viscérale et Oncologique, Hospices Civils de Lyon, Hôpital Lyon Sud, Lyon, France; Université de Lyon, Université Claude Bernard Lyon 1, EMR 3738, Oullins, France.
Grégoire M; CRCINA, INSERM, Université D'Angers, Université de Nantes, Nantes, France; Labex IGO, Immunology Graft Oncology, Nantes, France.
Micheau O; Université Bourgogne Franche-Comté, INSERM, LNC UMR1231, F-21079, Dijon, France.
Blanquart C; CRCINA, INSERM, Université D'Angers, Université de Nantes, Nantes, France; Labex IGO, Immunology Graft Oncology, Nantes, France.
Renno T; Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Cancer Research Center of Lyon, Lyon, France.
Fonteneau JF; CRCINA, INSERM, Université D'Angers, Université de Nantes, Nantes, France; Labex IGO, Immunology Graft Oncology, Nantes, France.
Lebecque S; Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Cancer Research Center of Lyon, Lyon, France; Service D'Anatomie Pathologique, Hospices Civils de Lyon, Hôpital Lyon Sud, Pierre-Bénite, France.
Mahtouk K; Univ Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Cancer Research Center of Lyon, Lyon, France. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2020 Mar 01; Vol. 472, pp. 29-39. Date of Electronic Publication: 2019 Dec 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*drug effects
CASP8 and FADD-Like Apoptosis Regulating Protein/*genetics
Lung Neoplasms/*drug therapy
Mesothelioma/*drug therapy
Toll-Like Receptor 3/*genetics
Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Caspase 8/genetics ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cisplatin/pharmacology ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Lung Neoplasms/genetics ; Lung Neoplasms/physiopathology ; Mesothelioma/genetics ; Mesothelioma/physiopathology ; Mesothelioma, Malignant ; Poly I-C/pharmacology ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Synthetic lethality of combined AT-101 with idarubicin in acute myeloid leukemia via blockade of DNA repair and activation of intrinsic apoptotic pathway.
Autorzy :
Yang Q; Department of Hematology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, 361003, China; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China.
Chen K; The First People's Hospital of Foshan (The Affiliated Foshan Hospital of Sun Yat-sen University), Foshan, Guangdong, 528000, China; Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China.
Zhang L; Department of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215000, China.
Feng L; Department of Hematology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, 361003, China.
Fu G; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China.
Jiang S; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China.
Bi S; Department of Hematology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, 361003, China.
Lin C; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China.
Zhou Y; Department of Hematology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, 361003, China.
Zhao H; Department of Hematology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, 361003, China.
Chen XL; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China.
Fu G; State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China. Electronic address: .
Xu B; Department of Hematology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, 361003, China. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2019 Oct 01; Vol. 461, pp. 31-43. Date of Electronic Publication: 2019 Jul 10.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Apoptosis/*drug effects
DNA Repair/*drug effects
Gene Expression Regulation, Neoplastic/*drug effects
Leukemia, Myeloid, Acute/*drug therapy
Leukemia, Myeloid, Acute/*pathology
Synthetic Lethal Mutations/*drug effects
Adolescent ; Adult ; Aged ; Animals ; Biomarkers, Tumor/genetics ; Case-Control Studies ; Cell Proliferation/drug effects ; DNA Repair/genetics ; Drug Synergism ; Female ; Follow-Up Studies ; Gossypol/administration & dosage ; Gossypol/analogs & derivatives ; Humans ; Idarubicin/administration & dosage ; Leukemia, Myeloid, Acute/genetics ; Male ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Middle Aged ; Prognosis ; RUNX1 Translocation Partner 1 Protein/antagonists & inhibitors ; RUNX1 Translocation Partner 1 Protein/genetics ; Survival Rate ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays ; Young Adult ; fms-Like Tyrosine Kinase 3/antagonists & inhibitors ; fms-Like Tyrosine Kinase 3/genetics
Czasopismo naukowe
Tytuł :
A recombinant measles virus vaccine strain rMV-Hu191 has oncolytic effect against human gastric cancer by inducing apoptotic cell death requiring integrity of lipid raft microdomains.
Autorzy :
Lv Y; Zhejiang University School of Medicine, Hangzhou, 310000, Zhejiang, China. Electronic address: .
Zhou D; Zhejiang University School of Medicine, Hangzhou, 310000, Zhejiang, China. Electronic address: .
Hao XQ; Zhejiang University School of Medicine, Hangzhou, 310000, Zhejiang, China. Electronic address: .
Zhu MY; Zhejiang University School of Medicine, Hangzhou, 310000, Zhejiang, China. Electronic address: .
Zhang CD; Zhejiang University School of Medicine, Hangzhou, 310000, Zhejiang, China. Electronic address: .
Zhou DM; Children's Hospital, Zhejiang University School of Medicine, Hangzhou, 310052, Zhejiang, China. Electronic address: .
Wang JH; Children's Hospital, Zhejiang University School of Medicine, Hangzhou, 310052, Zhejiang, China. Electronic address: .
Liu RX; Zhejiang University School of Medicine, Hangzhou, 310000, Zhejiang, China. Electronic address: .
Wang YL; Children's Hospital, Zhejiang University School of Medicine, Hangzhou, 310052, Zhejiang, China. Electronic address: .
Gu WZ; Children's Hospital, Zhejiang University School of Medicine, Hangzhou, 310052, Zhejiang, China; Key Laboratory of Diagnosis and Treatment of Neonatal Diseases of Zhejiang Province, Hangzhou, 310052, Zhejiang, China. Electronic address: .
Shen HQ; Children's Hospital, Zhejiang University School of Medicine, Hangzhou, 310052, Zhejiang, China; Key Laboratory of Diagnosis and Treatment of Neonatal Diseases of Zhejiang Province, Hangzhou, 310052, Zhejiang, China. Electronic address: .
Chen X; Zhejiang University School of Medicine, Hangzhou, 310000, Zhejiang, China; Children's Hospital, Zhejiang University School of Medicine, Hangzhou, 310052, Zhejiang, China; Key Laboratory of Diagnosis and Treatment of Neonatal Diseases of Zhejiang Province, Hangzhou, 310052, Zhejiang, China. Electronic address: .
Zhao ZY; Zhejiang University School of Medicine, Hangzhou, 310000, Zhejiang, China; Children's Hospital, Zhejiang University School of Medicine, Hangzhou, 310052, Zhejiang, China; Key Laboratory of Diagnosis and Treatment of Neonatal Diseases of Zhejiang Province, Hangzhou, 310052, Zhejiang, China. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2019 Sep 28; Vol. 460, pp. 108-118. Date of Electronic Publication: 2019 Jun 19.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*
Oncolytic Virotherapy*
Measles virus/*pathogenicity
Membrane Microdomains/*virology
Oncolytic Viruses/*pathogenicity
Stomach Neoplasms/*therapy
Animals ; Cell Line, Tumor ; Cell Proliferation ; Chlorocebus aethiops ; Cytopathogenic Effect, Viral ; Humans ; Male ; Measles virus/genetics ; Membrane Cofactor Protein/metabolism ; Membrane Microdomains/metabolism ; Membrane Microdomains/pathology ; Mice, Nude ; Oncolytic Viruses/genetics ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/pathology ; Stomach Neoplasms/virology ; Tumor Burden ; Vero Cells ; Virus Internalization ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Small molecule inhibitor agerafenib effectively suppresses neuroblastoma tumor growth in mouse models via inhibiting ERK MAPK signaling.
Autorzy :
Li H; Texas Children's Cancer Center, Department of Pediatrics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, 77030, USA; Department of Cardiothoracic Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, PR China.
Yu Y; Texas Children's Cancer Center, Department of Pediatrics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, 77030, USA.
Zhao Y; Texas Children's Cancer Center, Department of Pediatrics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, 77030, USA.
Wu D; Texas Children's Cancer Center, Department of Pediatrics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, 77030, USA.
Yu X; Texas Children's Cancer Center, Department of Pediatrics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, 77030, USA.
Lu J; Texas Children's Cancer Center, Department of Pediatrics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, 77030, USA.
Chen Z; Division of Pediatric Surgery, Texas Children's Hospital Department of Surgery, Michael E. DeBakey Department of Surgery, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, 77030, USA.
Zhang H; Texas Children's Cancer Center, Department of Pediatrics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, 77030, USA.
Hu Y; Texas Children's Cancer Center, Department of Pediatrics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, 77030, USA.
Zhai Y; Texas Children's Cancer Center, Department of Pediatrics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, 77030, USA.
Su J; Texas Children's Cancer Center, Department of Pediatrics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, 77030, USA.
Aheman A; Division of Pediatric Surgery, Texas Children's Hospital Department of Surgery, Michael E. DeBakey Department of Surgery, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, 77030, USA.
De Las Casas A; Texas Children's Cancer Center, Department of Pediatrics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, 77030, USA.
Jin J; Texas Children's Cancer Center, Department of Pediatrics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, 77030, USA.
Xu X; Texas Children's Cancer Center, Department of Pediatrics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, 77030, USA.
Shi Z; Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, 77030, USA.
Woodfield SE; Division of Pediatric Surgery, Texas Children's Hospital Department of Surgery, Michael E. DeBakey Department of Surgery, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, 77030, USA.
Vasudevan SA; Division of Pediatric Surgery, Texas Children's Hospital Department of Surgery, Michael E. DeBakey Department of Surgery, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, 77030, USA.
Agarwal S; Texas Children's Cancer Center, Department of Pediatrics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, 77030, USA.
Yan Y; Department of Cardiothoracic Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, PR China.
Yang J; Texas Children's Cancer Center, Department of Pediatrics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, 77030, USA. Electronic address: .
Foster JH; Texas Children's Cancer Center, Department of Pediatrics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, 77030, USA. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2019 Aug 10; Vol. 457, pp. 129-141. Date of Electronic Publication: 2019 May 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Apoptosis/*drug effects
Cell Proliferation/*drug effects
Doxorubicin/*pharmacology
Extracellular Signal-Regulated MAP Kinases/*antagonists & inhibitors
Neuroblastoma/*drug therapy
Phenylurea Compounds/*pharmacology
Protein Kinase Inhibitors/*pharmacology
Quinazolines/*pharmacology
Animals ; Cell Line, Tumor ; Dose-Response Relationship, Drug ; Drug Synergism ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Female ; Humans ; Mice, Nude ; Mice, Transgenic ; N-Myc Proto-Oncogene Protein/genetics ; Neuroblastoma/enzymology ; Neuroblastoma/genetics ; Neuroblastoma/pathology ; Signal Transduction ; Tumor Burden/drug effects ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Combined Bcl-2/Src inhibition synergize to deplete stem-like breast cancer cells.
Autorzy :
Sun Q; Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA; Department of Pathology, University of California, San Diego, La Jolla, CA, 92093, USA.
Wang Y; Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA; Department of Pathology, University of California, San Diego, La Jolla, CA, 92093, USA.
Desgrosellier JS; Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA; Department of Pathology, University of California, San Diego, La Jolla, CA, 92093, USA. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2019 Aug 10; Vol. 457, pp. 40-46. Date of Electronic Publication: 2019 May 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Apoptosis/*drug effects
Breast Neoplasms/*drug therapy
Bridged Bicyclo Compounds, Heterocyclic/*pharmacology
Dasatinib/*pharmacology
Neoplastic Stem Cells/*drug effects
Protein Kinase Inhibitors/*pharmacology
Proto-Oncogene Proteins c-bcl-2/*antagonists & inhibitors
Sulfonamides/*pharmacology
src-Family Kinases/*antagonists & inhibitors
Apoptosis Regulatory Proteins/genetics ; Apoptosis Regulatory Proteins/metabolism ; Breast Neoplasms/enzymology ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Female ; Humans ; MCF-7 Cells ; Neoplastic Stem Cells/enzymology ; Neoplastic Stem Cells/pathology ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/metabolism ; Proto-Oncogene Proteins c-bcl-2/metabolism ; Signal Transduction ; Spheroids, Cellular ; src-Family Kinases/metabolism
Czasopismo naukowe
Tytuł :
Hepatoma-derived growth factor supports the antiapoptosis and profibrosis of pancreatic stellate cells.
Autorzy :
Chen YT; Department of Biotechnology and Bioindustry Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, Taiwan; Medical Research Department, Chi Mei Medical Center, Tainan, Taiwan.
Chen FW; Institute of Basic Medical Science, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Chang TH; Institute of Basic Medical Science, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Wang TW; Department of Biotechnology and Bioindustry Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, Taiwan.
Hsu TP; Department of Life Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, Taiwan.
Chi JY; Department of Biotechnology and Bioindustry Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, Taiwan.
Hsiao YW; Department of Biotechnology and Bioindustry Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, Taiwan.
Li CF; Medical Research Department, Chi Mei Medical Center, Tainan, Taiwan; Department of Pathology, Chi Mei Medical Center, Tainan, Taiwan. Electronic address: .
Wang JM; Department of Biotechnology and Bioindustry Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, Taiwan; International Research Center for Wound Repair and Regeneration, National Cheng Kung University, Tainan, Taiwan; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2019 Aug 10; Vol. 457, pp. 180-190. Date of Electronic Publication: 2019 May 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Video-Audio Media
MeSH Terms :
Apoptosis*/drug effects
Intercellular Signaling Peptides and Proteins/*metabolism
Pancreatic Neoplasms/*metabolism
Pancreatic Stellate Cells/*metabolism
Animals ; CCAAT-Enhancer-Binding Protein-delta/metabolism ; Cell Line, Tumor ; Coculture Techniques ; Fibrosis ; Gene Expression Regulation, Neoplastic ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Intercellular Signaling Peptides and Proteins/pharmacology ; Mice, Inbred NOD ; Mice, SCID ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/pathology ; Pancreatic Stellate Cells/drug effects ; Pancreatic Stellate Cells/pathology ; Signal Transduction ; Transforming Growth Factor beta1/pharmacology ; Tumor Microenvironment
Czasopismo naukowe
Tytuł :
Targeting the deubiquitinase STAMBPL1 triggers apoptosis in prostate cancer cells by promoting XIAP degradation.
Autorzy :
Chen X; Department of Urology, National Cancer Center, National Clinical Research Center For Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Shi H; Department of Urology, National Cancer Center, National Clinical Research Center For Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Bi X; Department of Urology, National Cancer Center, National Clinical Research Center For Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Li Y; Department of Urology, National Cancer Center, National Clinical Research Center For Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Huang Z; Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2019 Aug 01; Vol. 456, pp. 49-58. Date of Electronic Publication: 2019 Apr 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Peptide Hydrolases/*metabolism
Prostatic Neoplasms/*enzymology
X-Linked Inhibitor of Apoptosis Protein/*metabolism
Caspase 3/metabolism ; Caspase 7/metabolism ; Gene Expression Regulation, Enzymologic ; Gene Expression Regulation, Neoplastic ; Humans ; Lysosomes/metabolism ; Male ; NF-kappa B/metabolism ; PC-3 Cells ; Peptide Hydrolases/genetics ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/pathology ; Proteolysis ; Reactive Oxygen Species/metabolism ; Signal Transduction ; Ubiquitination
Czasopismo naukowe
Tytuł :
Tumor targeting and microenvironment-responsive multifunctional fusion protein for pro-apoptotic peptide delivery.
Autorzy :
Yin J; Jiangsu Key Laboratory of Druggability of Biopharmaceuticals and State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, 210009, China.
Liu D; Jiangsu Key Laboratory of Druggability of Biopharmaceuticals and State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, 210009, China.
Bao L; Jiangsu Key Laboratory of Druggability of Biopharmaceuticals and State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, 210009, China.
Wang Q; Jiangsu Key Laboratory of Druggability of Biopharmaceuticals and State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, 210009, China.
Chen Y; Jiangsu Key Laboratory of Druggability of Biopharmaceuticals and State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, 210009, China.
Hou S; Jiangsu Key Laboratory of Druggability of Biopharmaceuticals and State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, 210009, China.
Yue Y; Jiangsu Key Laboratory of Druggability of Biopharmaceuticals and State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, 210009, China.
Yao W; Jiangsu Key Laboratory of Druggability of Biopharmaceuticals and State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, 210009, China. Electronic address: .
Gao X; Jiangsu Key Laboratory of Druggability of Biopharmaceuticals and State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, 210009, China. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2019 Jun 28; Vol. 452, pp. 38-50. Date of Electronic Publication: 2019 Mar 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Carriers*
Tumor Microenvironment*
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Cell-Penetrating Peptides/*pharmacology
Neoplasms/*drug therapy
Animals ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/pharmacokinetics ; Cell Proliferation/drug effects ; Cell-Penetrating Peptides/administration & dosage ; Cell-Penetrating Peptides/pharmacokinetics ; Female ; Hep G2 Cells ; Humans ; MCF-7 Cells ; Matrix Metalloproteinase 2/metabolism ; Membrane Potential, Mitochondrial/drug effects ; Mice, Inbred BALB C ; Mice, Nude ; Mitochondria/drug effects ; Mitochondria/metabolism ; Mitochondria/pathology ; Molecular Targeted Therapy ; Neoplasms/enzymology ; Neoplasms/pathology ; Peptide Fragments/metabolism ; Polyglutamic Acid/metabolism ; Protein Domains ; Recombinant Fusion Proteins/pharmacology ; Signal Transduction ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Forced expression of DYRK2 exerts anti-tumor effects via apoptotic induction in liver cancer.
Autorzy :
Yokoyama-Mashima S; Department of Biochemistry, The Jikei University School of Medicine, Tokyo, Japan; Department of Gastroenterology and Hepatology, The Jikei University School of Medicine, Tokyo, Japan.
Yogosawa S; Department of Biochemistry, The Jikei University School of Medicine, Tokyo, Japan.
Kanegae Y; Core Research Facilities for Basic Science (Division of Molecular Genetics), Research Center for Medical Science, The Jikei University School of Medicine, Tokyo, Japan.
Hirooka S; Department of Pathology, The Jikei University School of Medicine, Tokyo, Japan.
Yoshida S; Department of Biochemistry, The Jikei University School of Medicine, Tokyo, Japan.
Horiuchi T; Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.
Ohashi T; Division of Gene Therapy, Research Center for Medical Science, The Jikei University School of Medicine, Tokyo, Japan.
Yanaga K; Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.
Saruta M; Department of Gastroenterology and Hepatology, The Jikei University School of Medicine, Tokyo, Japan.
Oikawa T; Department of Gastroenterology and Hepatology, The Jikei University School of Medicine, Tokyo, Japan.
Yoshida K; Department of Biochemistry, The Jikei University School of Medicine, Tokyo, Japan. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2019 Jun 01; Vol. 451, pp. 100-109. Date of Electronic Publication: 2019 Mar 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Liver Neoplasms/*metabolism
Liver Neoplasms/*pathology
Protein-Serine-Threonine Kinases/*metabolism
Protein-Tyrosine Kinases/*metabolism
Adenoviridae/genetics ; Animals ; Cell Line, Tumor ; Cell Proliferation ; Down-Regulation ; Heterografts ; Humans ; Mice ; Protein-Serine-Threonine Kinases/genetics ; Protein-Tyrosine Kinases/genetics ; Survival Analysis
Czasopismo naukowe
Tytuł :
Combination of 5-aminosalicylic acid and hyperthermia synergistically enhances apoptotic cell death in HSC-3 cells due to intracellular nitric oxide/peroxynitrite generation.
Autorzy :
Moniruzzaman R; Department of Oral and Maxillofacial Surgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan; Department of Radiology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan.
Rehman MU; Department of Radiology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan. Electronic address: .
Zhao QL; Department of Radiology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan.
Jawaid P; Department of Radiology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan.
Mitsuhashi Y; Department of Radiology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan.
Sakurai K; Department of Oral and Maxillofacial Surgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan.
Heshiki W; Department of Oral and Maxillofacial Surgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan.
Ogawa R; Department of Radiology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan.
Tomihara K; Department of Oral and Maxillofacial Surgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan.
Saitoh JI; Department of Radiology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan.
Noguchi K; Department of Radiology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan.
Kondo T; Department of Radiology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan. Electronic address: .
Noguchi M; Department of Oral and Maxillofacial Surgery, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan.
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Źródło :
Cancer letters [Cancer Lett] 2019 Jun 01; Vol. 451, pp. 58-67. Date of Electronic Publication: 2019 Mar 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Fever/*pathology
Mesalamine/*pharmacology
Nitric Oxide/*metabolism
Peroxynitrous Acid/*metabolism
Carcinoma, Squamous Cell/pathology ; Cell Line, Tumor ; Combined Modality Therapy ; Humans ; Mouth Neoplasms/pathology
Czasopismo naukowe
Tytuł :
NAD(P)H: Quinone oxidoreductase 1 overexpression in hepatocellular carcinoma potentiates apoptosis evasion through regulating stabilization of X-linked inhibitor of apoptosis protein.
Autorzy :
Li WY; The Key Laboratory of Molecular Biology of Infectious Diseases Designated by the Chinese Ministry of Education, Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Zhou HZ; The Key Laboratory of Molecular Biology of Infectious Diseases Designated by the Chinese Ministry of Education, Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Chen Y; Medical Examination Center, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Cai XF; The Key Laboratory of Molecular Biology of Infectious Diseases Designated by the Chinese Ministry of Education, Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Tang H; The Key Laboratory of Molecular Biology of Infectious Diseases Designated by the Chinese Ministry of Education, Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Ren JH; The Key Laboratory of Molecular Biology of Infectious Diseases Designated by the Chinese Ministry of Education, Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Wai Wong VK; State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China.
Kwan Law BY; State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China.
Chen Y; Department of Hepatobliliary Surgery, First Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Cheng ST; The Key Laboratory of Molecular Biology of Infectious Diseases Designated by the Chinese Ministry of Education, Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Yu HB; The Key Laboratory of Molecular Biology of Infectious Diseases Designated by the Chinese Ministry of Education, Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Cai HY; Center of Growth, Metabolism, and Aging, Key Laboratory of Bio-Resources and Eco-Environment, College of Life Sciences, Sichuan University, Chengdu, China.
Chen WX; Department of Clinical Laboratory, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Tang N; The Key Laboratory of Molecular Biology of Infectious Diseases Designated by the Chinese Ministry of Education, Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Zhang WL; The Key Laboratory of Molecular Biology of Infectious Diseases Designated by the Chinese Ministry of Education, Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Tao NN; The Key Laboratory of Molecular Biology of Infectious Diseases Designated by the Chinese Ministry of Education, Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Yang QX; The Key Laboratory of Molecular Biology of Infectious Diseases Designated by the Chinese Ministry of Education, Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Ren F; The Key Laboratory of Molecular Biology of Infectious Diseases Designated by the Chinese Ministry of Education, Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
He L; The Key Laboratory of Molecular Biology of Infectious Diseases Designated by the Chinese Ministry of Education, Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Jiang H; The Key Laboratory of Molecular Biology of Infectious Diseases Designated by the Chinese Ministry of Education, Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Huang AL; The Key Laboratory of Molecular Biology of Infectious Diseases Designated by the Chinese Ministry of Education, Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China. Electronic address: .
Chen J; The Key Laboratory of Molecular Biology of Infectious Diseases Designated by the Chinese Ministry of Education, Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2019 Jun 01; Vol. 451, pp. 156-167. Date of Electronic Publication: 2019 Mar 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Carcinoma, Hepatocellular/*enzymology
Liver Neoplasms/*enzymology
NAD(P)H Dehydrogenase (Quinone)/*metabolism
X-Linked Inhibitor of Apoptosis Protein/*metabolism
Animals ; Carcinoma, Hepatocellular/pathology ; Cell Line, Transformed ; Humans ; Liver Neoplasms/pathology ; Male ; Mice ; Mice, Inbred BALB C ; NAD(P)H Dehydrogenase (Quinone)/genetics ; Phosphorylation
Czasopismo naukowe
Tytuł :
Blocking autophagy flux promotes interferon-alpha-mediated apoptosis in head and neck squamous cell carcinoma.
Autorzy :
Yang W; Department of Oral Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China; Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai, 200011, China.
Jiang C; Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai, 200011, China; Department of Prosthodontics, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Xia W; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Ju H; Department of Oral Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China; Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai, 200011, China.
Jin S; Department of Oral Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China; Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai, 200011, China.
Liu S; Department of Oral Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China; Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai, 200011, China.
Zhang L; Department of Oral Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China; Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai, 200011, China.
Ren G; Department of Oral Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China; Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai, 200011, China.
Ma H; Department of Oral Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China; Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai, 200011, China. Electronic address: .
Ruan M; Department of Oral Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China; Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai, 200011, China. Electronic address: .
Hu J; Department of Oral Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China; Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai, 200011, China. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2019 Jun 01; Vol. 451, pp. 34-47. Date of Electronic Publication: 2019 Mar 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*drug effects
Autophagy/*drug effects
Head and Neck Neoplasms/*pathology
Interferon-alpha/*pharmacology
Squamous Cell Carcinoma of Head and Neck/*pathology
Animals ; Autophagy-Related Protein 5/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Heterografts ; Humans ; Mice ; Mice, Inbred BALB C ; STAT1 Transcription Factor/metabolism
Czasopismo naukowe
Tytuł :
MIR-1265 regulates cellular proliferation and apoptosis by targeting calcium binding protein 39 in gastric cancer and, thereby, impairing oncogenic autophagy.
Autorzy :
Xu Z; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu province, China.
Li Z; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu province, China.
Wang W; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu province, China.
Xia Y; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu province, China.
He Z; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu province, China.
Li B; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu province, China.
Wang S; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu province, China.
Huang X; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu province, China.
Sun G; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu province, China.
Xu J; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu province, China.
Wang L; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu province, China.
Zhang Q; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu province, China.
Li Q; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu province, China.
Lv J; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu province, China.
Wang L; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu province, China.
Zhang L; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu province, China.
Zhang D; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu province, China.
Xu H; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu province, China.
Xu Z; Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu province, China; Collaborative Innovation Center For Cancer Personalized Medicine, Nanjing Medical University, Nanjing, 210029, Jiangsu province, China. Electronic address: .
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Źródło :
Cancer letters [Cancer Lett] 2019 May 01; Vol. 449, pp. 226-236. Date of Electronic Publication: 2019 Feb 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Autophagy*
Cell Proliferation*
Calcium-Binding Proteins/*metabolism
MicroRNAs/*metabolism
Stomach Neoplasms/*metabolism
AMP-Activated Protein Kinases/metabolism ; Autophagy-Related Protein 12/genetics ; Autophagy-Related Protein 12/metabolism ; Calcium-Binding Proteins/genetics ; Cell Line, Tumor ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; MicroRNAs/genetics ; Middle Aged ; Signal Transduction ; Stomach Neoplasms/genetics ; Stomach Neoplasms/pathology ; TOR Serine-Threonine Kinases/metabolism
Czasopismo naukowe

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