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Tytuł :
Neonatal-onset multisystem inflammatory disease responsive to interleukin-1beta inhibition.
Autorzy :
Goldbach-Mansky R ()
Dailey NJ ()
Canna SW ()
Gelabert A ()
Jones J ()
Rubin BI ()
Kim HJ ()
Brewer C ()
Zalewski C ()
Wiggs E ()
Hill S ()
Turner ML ()
Karp BI ()
Askentijevich I ()
Pucino F ()
Penzak SR ()
Haverkamp MH ()
Stein L ()
Adams BS ()
Moore TL ()
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Źródło :
New England Journal of Medicine. 8/10/2006, Vol. 355 Issue 6, p581-592. 12p.
Czasopismo naukowe
Tytuł :
Genetic and commensal induction of IL-18 drive intestinal epithelial MHCII via IFNγ.
Autorzy :
Van Der Kraak LA; R.K. Mellon Institute for Pediatric Research, Pediatric Rheumatology, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA. .
Schneider C; R.K. Mellon Institute for Pediatric Research, Pediatric Rheumatology, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.
Dang V; R.K. Mellon Institute for Pediatric Research, Pediatric Rheumatology, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.; The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Burr AHP; R.K. Mellon Institute for Pediatric Research, Pediatric Infectious Disease, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.; Program in Microbiology and Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
Weiss ES; R.K. Mellon Institute for Pediatric Research, Pediatric Rheumatology, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.
Varghese JA; R.K. Mellon Institute for Pediatric Research, Pediatric Rheumatology, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.
Yang L; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; Molecular Genetics and Microbiology, Duke University, Durham, NC, USA.
Hand TW; R.K. Mellon Institute for Pediatric Research, Pediatric Infectious Disease, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.
Canna SW; R.K. Mellon Institute for Pediatric Research, Pediatric Rheumatology, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA. .; The Children's Hospital of Philadelphia, Philadelphia, PA, USA. .
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Źródło :
Mucosal immunology [Mucosal Immunol] 2021 Jun 08. Date of Electronic Publication: 2021 Jun 08.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Immunodeficiency and bone marrow failure with mosaic and germline TLR8 gain of function.
Autorzy :
Aluri J; Division of Rheumatology/Immunology and.
Bach A; Division of Hematology/Oncology, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO.
Kaviany S; Pediatric Hematology Oncology, Vanderbilt University Medical Center, Nashville, TN.
Chiquetto Paracatu L; Division of Hematology/Oncology, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO.
Kitcharoensakkul M; Division of Rheumatology/Immunology and.; Division of Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO.
Walkiewicz MA; Centralized Sequencing Initiative, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.
Putnam CD; Department of Medicine, University of California School of Medicine, San Diego, La Jolla, CA.; San Diego Branch, Ludwig Institute for Cancer Research, La Jolla, CA.
Shinawi M; Division of Genetics and Genomic Medicine, Department of Pediatrics and.
Saucier N; Division of Rheumatology/Immunology and.
Rizzi EM; Division of Allergy and Immunology, Department of Medicine, Washington University School of Medicine, St. Louis, MO.
Harmon MT; Division of Rheumatology/Immunology and.
Keppel MP; Division of Rheumatology/Immunology and.
Ritter M; Division of Rheumatology/Immunology and.
Similuk M; Centralized Sequencing Initiative, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.
Kulm E; Clinical Research Directorate, Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute, Frederick, MD.
Joyce M; Nemours Children's Specialty Care, Jacksonville, FL.
de Jesus AA; Translational Autoinflammatory Diseases Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.
Goldbach-Mansky R; Translational Autoinflammatory Diseases Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.
Lee YS; Division of Anatomic and Molecular Pathology and.
Cella M; Division of Immunology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO.
Kendall PL; Division of Allergy and Immunology, Department of Medicine, Washington University School of Medicine, St. Louis, MO.; Division of Immunology, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO.
Dinauer MC; Division of Hematology/Oncology, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO.
Bednarski JJ; Division of Hematology/Oncology, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO.
Bemrich-Stolz C; Division of Hematology and Oncology, Department of Pediatrics, University of Alabama School of Medicine, Birmingham, AL.
Canna SW; Division of Pediatric Rheumatology and RK Mellon Institute, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh and University of Pittsburgh, Pittsburgh, PA.
Abraham SM; Division of Hematology and Oncology, Department of Pediatrics, University of New Mexico, Albuquerque, NM.
Demczko MM; Division of Diagnostic Referral and.
Powell J; Division of Pediatric Hematology/Oncology, Department of Pediatrics, Nemours Alfred I. DuPont Hospital for Children, Wilmington, DE.
Jones SM; Division of Allergy and Immunology, Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock, AR.
Scurlock AM; Division of Allergy and Immunology, Department of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock, AR.
De Ravin SS; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD; and.
Bleesing JJ; Division of Bone Marrow Transplantation and Immunodeficiency, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Connelly JA; Pediatric Hematology Oncology, Vanderbilt University Medical Center, Nashville, TN.
Rao VK; Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD; and.
Schuettpelz LG; Division of Hematology/Oncology, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO.
Cooper MA; Division of Rheumatology/Immunology and.
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Źródło :
Blood [Blood] 2021 May 06; Vol. 137 (18), pp. 2450-2462.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Proteomic Profiling of MIS-C Patients Reveals Heterogeneity Relating to Interferon Gamma Dysregulation and Vascular Endothelial Dysfunction.
Autorzy :
Diorio C
Shraim R
Vella LA
Giles JR
Baxter AE
Oldridge DA
Canna SW
Henrickson SE
McNerney KO
Balamuth F
Burudpakdee C
Lee J
Leng T
Farrell A
Lambert MP
Sullivan KE
John Wherry E
Teachey DT
Bassiri H
Behrens EM
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Źródło :
MedRxiv : the preprint server for health sciences [medRxiv] 2021 Apr 20. Date of Electronic Publication: 2021 Apr 20.
Typ publikacji :
Preprint
Tytuł :
American College of Rheumatology Clinical Guidance for Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 and Hyperinflammation in Pediatric COVID-19: Version 2.
Autorzy :
Henderson LA; Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Canna SW; UPMC Children's Hospital of Pittsburgh and University of Pittsburgh, Pittsburgh, Pennsylvania.
Friedman KG; Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Gorelik M; Morgan Stanley Children's Hospital and Columbia University, New York, New York.
Lapidus SK; Joseph M. Sanzari Children's Hospital at Hackensack University Medical Center and Hackensack Meridian School of Medicine, Hackensack, New Jersey.
Bassiri H; Children's Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine.
Behrens EM; Children's Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine.
Ferris A; Columbia University Irving Medical Center, New York, New York.
Kernan KF; University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Schulert GS; Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio.
Seo P; Johns Hopkins University School of Medicine, Baltimore, Maryland.
Son MBF; Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Tremoulet AH; University of California San Diego and Rady Children's Hospital San Diego.
Yeung RSM; The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada.
Mudano AS; University of Alabama at Birmingham, Birmingham.
Turner AS; American College of Rheumatology, Atlanta, Georgia.
Karp DR; University of Texas Southwestern Medical Center, Dallas.
Mehta JJ; Children's Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine.
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Źródło :
Arthritis & rheumatology (Hoboken, N.J.) [Arthritis Rheumatol] 2021 Apr; Vol. 73 (4), pp. e13-e29. Date of Electronic Publication: 2021 Feb 15.
Typ publikacji :
Consensus Development Conference; Journal Article; Practice Guideline
MeSH Terms :
COVID-19/*diagnosis
COVID-19/*therapy
Systemic Inflammatory Response Syndrome/*diagnosis
Systemic Inflammatory Response Syndrome/*therapy
Adolescent ; Advisory Committees ; Anticoagulants/therapeutic use ; Antirheumatic Agents/therapeutic use ; Child ; Child, Preschool ; Delphi Technique ; Diagnosis, Differential ; Glucocorticoids/therapeutic use ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Immunologic Factors/therapeutic use ; Infant ; Infant, Newborn ; Inflammation ; Interleukin 1 Receptor Antagonist Protein/therapeutic use ; Mucocutaneous Lymph Node Syndrome/diagnosis ; Platelet Aggregation Inhibitors/therapeutic use ; Rheumatology ; SARS-CoV-2 ; Young Adult
SCR Disease Name :
pediatric multisystem inflammatory disease, COVID-19 related
Czasopismo naukowe
Tytuł :
Reply to Prophylactic Anticoagulation: Comment on the ACR Guidance for Management of Multisystem Inflammatory Syndrome in Children.
Autorzy :
Henderson LA; Division of Immunology, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Friedman KG; Department of Pediatric Cardiology, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Kernan KF; Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Canna SW; Department of Immunology, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.
Gorelik M; Division of Allergy, Immunology and Rheumatology, Morgan Stanley Children's Hospital, Department of Pediatrics, Columbia University, New York, NY, USA.
Lapidus SK; Division of Pediatric Rheumatology, Joseph M. Sanzari Children's Hospital, Hackensack Meridian Health Hackensack, Hackensack, NJ, USA.
Bassiri H; Division of Infectious Diseases, Children's Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Pittsburgh, PA, USA.
Behrens EM; Division of Rheumatology, Children's Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Pittsburgh, PA, USA.
Ferris A; Division of Pediatric Cardiology, Columbia University Irving Medical Center, Irving, NY, USA.
Schulert GS; Division of Rheumatology, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Seo P; Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Son MBF; Division of Immunology, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
Tremoulet AH; Department of Pediatrics, University of California San Diego/Rady Children's Hospital San Diego, San Diego, CA, USA.
Yeung RSM; Department of Paediatrics, Immunology and Medical Sciences, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Karp DR; Rheumatic Diseases Division, UT Southwestern Medical Center, Dallas, TX, USA.
Mehta JJ; Division of Rheumatology, Children's Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Pittsburgh, PA, USA.
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Źródło :
Arthritis & rheumatology (Hoboken, N.J.) [Arthritis Rheumatol] 2021 Feb 14. Date of Electronic Publication: 2021 Feb 14.
Typ publikacji :
Letter
Opinia redakcyjna
Tytuł :
Systemic and Nodular Hyperinflammation in a Patient with Refractory Familial Hemophagocytic Lymphohistiocytosis 2.
Autorzy :
Segal JE; Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
Daley JD; Division of Hematology/Oncology, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
Barnum JL; Division of Blood and Marrow Transplantation and Cellular Therapies, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
Salgado CM; Department of Pathology, UPMC, Pittsburgh, PA, USA.
Reyes-Mugica M; Department of Pathology, UPMC, Pittsburgh, PA, USA.
Schneider C; Division of Rheumatology, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
Gumus S; Department of Radiology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
Thakrar D; Department of Radiology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
Allen SW; Division of Hematology/Oncology, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA.
Canna SW; Division of Rheumatology, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA. scott.canna@chp.edu.; RK Mellon Institute, UPMC Children's Hospital of Pittsburgh, 8124 Rangos Research Building, 4401 Penn Ave, Pittsburgh, PA, 15224, USA. scott.canna@chp.edu.
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Źródło :
Journal of clinical immunology [J Clin Immunol] 2021 Feb 11. Date of Electronic Publication: 2021 Feb 11.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
An immune-based biomarker signature is associated with mortality in COVID-19 patients.
Autorzy :
Abers MS; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Delmonte OM; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Ricotta EE; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Fintzi J; Biostatistics Research Branch, NIAID, NIH, Bethesda, Maryland, USA.
Fink DL; Neutrophil Monitoring Laboratory, Leidos Biomedical Research, Inc, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
de Jesus AAA; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Zarember KA; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Alehashemi S; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Oikonomou V; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Desai JV; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Canna SW; Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Shakoory B; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Dobbs K; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Imberti L; CREA Laboratory, Diagnostic Department, ASST Spedali Civili di Brescia, Brescia, Italy.
Sottini A; CREA Laboratory, Diagnostic Department, ASST Spedali Civili di Brescia, Brescia, Italy.
Quiros-Roldan E; Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali Civili di Brescia, Brescia, Italy.
Castelli F; Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali Civili di Brescia, Brescia, Italy.
Rossi C; Direzione Sanitaria, ASST Spedali Civili di Brescia, Italy.
Brugnoni D; Laboratorio Analisi Chimico-Cliniche, ASST Spedali Civili, Brescia, Italy.
Biondi A; Pediatric Department and Centro Tettamanti-European Reference Network on Paediatric Cancer, European Reference Network on Haematological Diseases, and European Reference Network on Hereditary Metabolic Disorders-University of Milano-Bicocca-Fondazione MBBM, Monza, Italy.
Bettini LR; Pediatric Department and Centro Tettamanti-European Reference Network on Paediatric Cancer, European Reference Network on Haematological Diseases, and European Reference Network on Hereditary Metabolic Disorders-University of Milano-Bicocca-Fondazione MBBM, Monza, Italy.
D'Angio' M; Pediatric Department and Centro Tettamanti-European Reference Network on Paediatric Cancer, European Reference Network on Haematological Diseases, and European Reference Network on Hereditary Metabolic Disorders-University of Milano-Bicocca-Fondazione MBBM, Monza, Italy.
Bonfanti P; Department of Infectious Diseases, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy.
Castagnoli R; Department of Pediatrics and.
Montagna D; Laboratory of Immunology and Transplantation, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.; Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy.
Licari A; Department of Pediatrics and.
Marseglia GL; Department of Pediatrics and.
Gliniewicz EF; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Shaw E; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Kahle DE; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Rastegar AT; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Stack M; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Myint-Hpu K; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Levinson SL; BioAegis Therapeutics, Inc, North Brunswick, New Jersey, USA.
DiNubile MJ; BioAegis Therapeutics, Inc, North Brunswick, New Jersey, USA.
Chertow DW; Critical Care Medicine Department, NIH Clinical Center, NIH, Bethesda, Maryland, USA.
Burbelo PD; National Institute of Dental and Craniofacial Research, NIH, Bethesda, Maryland, USA.
Cohen JI; Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, Maryland, USA.
Calvo KR; Hematology Section, Department of Laboratory Medicine, NIH Clinical Center, NIH, Bethesda, Maryland, USA.
Tsang JS; Laboratory of Immune System Biology and Clinical Genomics Program, NIAID, NIH, Bethesda, Maryland, USA.; Center for Human Immunology, Autoimmunity, and Inflammation, NIAID, NIH, Bethesda, Maryland, USA.
Su HC; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Gallin JI; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Kuhns DB; Neutrophil Monitoring Laboratory, Leidos Biomedical Research, Inc, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
Goldbach-Mansky R; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Lionakis MS; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Notarangelo LD; Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, USA.
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Corporate Authors :
NIAID COVID-19 Consortium
Źródło :
JCI insight [JCI Insight] 2021 Jan 11; Vol. 6 (1). Date of Electronic Publication: 2021 Jan 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms :
COVID-19/*immunology
COVID-19/*mortality
Adrenal Cortex Hormones/therapeutic use ; Adult ; Aged ; Anti-Bacterial Agents/therapeutic use ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antiviral Agents/therapeutic use ; Azithromycin/therapeutic use ; Biomarkers ; COVID-19/genetics ; COVID-19/therapy ; Calgranulin B/genetics ; Calgranulin B/immunology ; Case-Control Studies ; Chemokine CCL2/genetics ; Chemokine CCL2/immunology ; Chemokine CXCL9/genetics ; Chemokine CXCL9/immunology ; Enzyme Inhibitors/therapeutic use ; Female ; Ferritins/genetics ; Ferritins/immunology ; Gene Expression Profiling ; Humans ; Hydroxychloroquine/therapeutic use ; Immunologic Factors/therapeutic use ; Interferon Type I/genetics ; Interferon Type I/immunology ; Interferon-gamma/genetics ; Interferon-gamma/immunology ; Interleukin-1 Receptor-Like 1 Protein/genetics ; Interleukin-1 Receptor-Like 1 Protein/immunology ; Interleukin-10/genetics ; Interleukin-10/immunology ; Interleukin-15/genetics ; Interleukin-15/immunology ; Interleukin-2/genetics ; Interleukin-2/immunology ; Interleukin-6/genetics ; Interleukin-6/immunology ; Lactoferrin/genetics ; Lactoferrin/immunology ; Lipocalin-2/genetics ; Lipocalin-2/immunology ; Male ; Matrix Metalloproteinase 9/genetics ; Matrix Metalloproteinase 9/immunology ; Middle Aged ; Multivariate Analysis ; NF-kappa B/genetics ; NF-kappa B/immunology ; Prognosis ; Receptors, Tumor Necrosis Factor, Type I/genetics ; Receptors, Tumor Necrosis Factor, Type I/immunology ; SARS-CoV-2 ; Severity of Illness Index ; Vascular Endothelial Growth Factor Receptor-1/genetics ; Vascular Endothelial Growth Factor Receptor-1/immunology
Czasopismo naukowe
Tytuł :
Interleukin-18 and cytotoxic impairment are independent and synergistic causes of murine virus-induced hyperinflammation.
Autorzy :
Tsoukas P; Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA.; Department of Rheumatology, Hospital for Sick Children, Toronto, ON, Canada.
Rapp E; Department of Immunology and.
Van Der Kraak L; Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA.
Weiss ES; Department of Immunology and.
Dang V; Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA.
Schneider C; Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA.
Klein E; Division of Laboratory Animal Resources, University of Pittsburgh, Pittsburgh, PA.
Picarsic J; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA.; Division of Pathology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; and.
Salcedo R; Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Stewart CA; Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Canna SW; Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA.; Department of Immunology and.
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Źródło :
Blood [Blood] 2020 Nov 05; Vol. 136 (19), pp. 2162-2174.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
CD8-Positive T-Lymphocytes/*immunology
Inflammation/*pathology
Intercellular Signaling Peptides and Proteins/*physiology
Interleukin-18/*metabolism
Lymphocytic Choriomeningitis/*complications
Lymphocytic choriomeningitis virus/*pathogenicity
Perforin/*physiology
Animals ; Female ; Inflammation/etiology ; Inflammation/metabolism ; Interferon-gamma/metabolism ; Interleukin-18/genetics ; Lymphocyte Activation ; Lymphocytic Choriomeningitis/virology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic
Czasopismo naukowe
Tytuł :
Highways to hell: Mechanism-based management of cytokine storm syndromes.
Autorzy :
Canna SW; University of Pittsburgh/UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pa. Electronic address: Scott.canna@chp.edu.
Cron RQ; University of Alabama, Birmingham/Children's of Alabama, Birmingham, Ala.
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Źródło :
The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2020 Nov; Vol. 146 (5), pp. 949-959. Date of Electronic Publication: 2020 Sep 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Cytokine Release Syndrome/*therapy
Immunotherapy, Adoptive/*adverse effects
Virus Diseases/*immunology
Animals ; Cytokine Release Syndrome/diagnosis ; Cytokine Release Syndrome/etiology ; Cytotoxicity, Immunologic ; Humans ; Inflammation ; Interleukin-18/metabolism ; Lymphohistiocytosis, Hemophagocytic ; Macrophage Activation Syndrome ; Virus Diseases/complications
Czasopismo naukowe
Tytuł :
American College of Rheumatology Clinical Guidance for Multisystem Inflammatory Syndrome in Children Associated With SARS-CoV-2 and Hyperinflammation in Pediatric COVID-19: Version 1.
Autorzy :
Henderson LA; Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Canna SW; UPMC Children's Hospital of Pittsburgh and University of Pittsburgh, Pittsburgh, Pennsylvania.
Friedman KG; Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Gorelik M; Morgan Stanley Children's Hospital and Columbia University, New York, New York.
Lapidus SK; Joseph M. Sanzari Children's Hospital at Hackensack University Medical Center and Hackensack Meridian School of Medicine, Hackensack, New Jersey.
Bassiri H; Children's Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine.
Behrens EM; Children's Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine.
Ferris A; Columbia University Irving Medical Center, New York, New York.
Kernan KF; University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Schulert GS; Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio.
Seo P; Johns Hopkins University School of Medicine, Baltimore, Maryland.
F Son MB; Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Tremoulet AH; University of California San Diego and Rady Children's Hospital San Diego.
Yeung RSM; Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada.
Mudano AS; University of Alabama at Birmingham.
Turner AS; American College of Rheumatology, Atlanta, Georgia.
Karp DR; University of Texas Southwestern Medical Center, Dallas.
Mehta JJ; Children's Hospital of Philadelphia and University of Pennsylvania Perelman School of Medicine.
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Źródło :
Arthritis & rheumatology (Hoboken, N.J.) [Arthritis Rheumatol] 2020 Nov; Vol. 72 (11), pp. 1791-1805. Date of Electronic Publication: 2020 Oct 03.
Typ publikacji :
Journal Article; Practice Guideline
MeSH Terms :
COVID-19/*complications
Systemic Inflammatory Response Syndrome/*therapy
COVID-19/etiology ; COVID-19/therapy ; Consensus ; Humans ; Systemic Inflammatory Response Syndrome/etiology
SCR Disease Name :
pediatric multisystem inflammatory disease, COVID-19 related
Czasopismo naukowe
Tytuł :
Proceedings from the 2 Next Gen Therapies for Systemic Juvenile Idiopathic Arthritis and Macrophage Activation Syndrome symposium held on October 3-4, 2019.
Autorzy :
Canna SW; University of Pittsburgh, Pittsburg, PA, USA.
Schulert GS; Division of Rheumatology, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, USA. .
de Jesus A; Intramural Research Program, National Institute of Allergy and Infectious Diseases, NIH, North Bethesda, USA.
Pickering A; Harvard Medical School, Boston, MA, USA.
Brunner H; Division of Rheumatology, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, USA.
Gadina M; Intramural Research Program, National Institute of Allergy and Infectious Diseases, NIH, North Bethesda, USA.
Levine S; Intramural Research Program, National Institute of Allergy and Infectious Diseases, NIH, North Bethesda, USA.
Goldbach-Mansky R; Intramural Research Program, National Institute of Allergy and Infectious Diseases, NIH, North Bethesda, USA.
Boutelle J; SJIA Foundation, Cincinnati, USA.
Sinha R; SJIA Foundation, Cincinnati, USA.
DeBenedetti F; Ospedale Pediatrico Bambino Gesù, Rome, Italy.
Grom A; Division of Rheumatology, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, USA. .
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Corporate Authors :
NextGen 2019 Participants
Źródło :
Pediatric rheumatology online journal [Pediatr Rheumatol Online J] 2020 Jul 15; Vol. 18 (Suppl 1), pp. 53. Date of Electronic Publication: 2020 Jul 15.
Typ publikacji :
Congress
MeSH Terms :
Arthritis, Juvenile/*therapy
Macrophage Activation Syndrome/*therapy
Arthritis, Juvenile/diagnosis ; Arthritis, Juvenile/pathology ; Biomarkers ; Child ; Child, Preschool ; Disease Progression ; Humans ; Infant ; Macrophage Activation Syndrome/diagnosis ; Macrophage Activation Syndrome/pathology
Tytuł :
On the Alert for Cytokine Storm: Immunopathology in COVID-19.
Autorzy :
Henderson LA; Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Canna SW; UPMC Children's Hospital of Pittsburgh and University of Pittsburgh, Pittsburgh, Pennsylvania.
Schulert GS; Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio.
Volpi S; Center for Autoinflammatory Diseases and Immunodeficiency, IRCCS Istituto Giannina Gaslini, and Università degli Studi di Genova, Genoa, Italy.
Lee PY; Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Kernan KF; UPMC Children's Hospital of Pittsburgh and University of Pittsburgh, Pittsburgh, Pennsylvania.
Caricchio R; Temple University Hospital and Lewis Katz School of Medicine, Philadelphia, Pennsylvania.
Mahmud S; University of Minnesota Medical Center and University of Minnesota School of Medicine, Minneapolis.
Hazen MM; Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Halyabar O; Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Hoyt KJ; Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Han J; Icahn School of Medicine at Mount Sinai, New York, New York.
Grom AA; Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio.
Gattorno M; Center for Autoinflammatory Diseases and Immunodeficiency, IRCCS Istituto Giannina Gaslini, and Università degli Studi di Genova, Genoa, Italy.
Ravelli A; Clinica Pediatrica e Reumatologia, IRCCS Istituto Giannina Gaslini, and Università degli Studi di Genova, Genoa, Italy.
De Benedetti F; Ospedale Pediatrico Bambino Gesù, Rome, Italy.
Behrens EM; Children's Hospital of Philadelphia and the University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Cron RQ; Children's of Alabama, University of Alabama at Birmingham, Birmingham.
Nigrovic PA; Boston Children's Hospital, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts.
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Źródło :
Arthritis & rheumatology (Hoboken, N.J.) [Arthritis Rheumatol] 2020 Jul; Vol. 72 (7), pp. 1059-1063. Date of Electronic Publication: 2020 May 10.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-Inflammatory Agents/*therapeutic use
Coronavirus Infections/*immunology
Cytokine Release Syndrome/*drug therapy
Cytokine Release Syndrome/*virology
Pneumonia, Viral/*immunology
Betacoronavirus ; Biomarkers ; COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/therapy ; Cytokine Release Syndrome/diagnosis ; Early Medical Intervention ; Humans ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/therapy ; SARS-CoV-2
Czasopismo naukowe
Tytuł :
Should COVID-19 take advice from rheumatologists?
Autorzy :
Kernan KF; Department of Critical Care Medicine, UPMC, Pittsburgh, PA 15224, USA.
Canna SW; Division of Pediatric Rheumatology, UPMC, Pittsburgh, PA 15224, USA.; UPMC Children's Hospital of Pittsburgh, and Department of Immunology, UPMC, Pittsburgh, PA 15224, USA.
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Źródło :
The Lancet Rheumatology [Lancet Rheumatol] 2020 Jun; Vol. 2 (6), pp. e310-e311. Date of Electronic Publication: 2020 May 07.
Typ publikacji :
Journal Article
Czasopismo naukowe
Tytuł :
Pediatric hemophagocytic lymphohistiocytosis.
Autorzy :
Canna SW; Division of Rheumatology, University of Pittsburgh, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA; and.
Marsh RA; Division of Bone Marrow Transplantation and Immune Deficiency, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
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Źródło :
Blood [Blood] 2020 Apr 16; Vol. 135 (16), pp. 1332-1343.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Lymphohistiocytosis, Hemophagocytic/*diagnosis
Lymphohistiocytosis, Hemophagocytic/*therapy
Animals ; CARD Signaling Adaptor Proteins/genetics ; Calcium-Binding Proteins/genetics ; Child ; Disease Management ; Epstein-Barr Virus Infections/complications ; F-Box-WD Repeat-Containing Protein 7/genetics ; Genetic Predisposition to Disease ; Genetic Variation ; Humans ; Lymphohistiocytosis, Hemophagocytic/genetics ; Lymphohistiocytosis, Hemophagocytic/physiopathology ; Signaling Lymphocytic Activation Molecule Associated Protein/genetics ; X-Linked Inhibitor of Apoptosis Protein/genetics
Czasopismo naukowe
Tytuł :
Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases.
Autorzy :
de Jesus AA; Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
Hou Y; Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China.
Brooks S; Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
Malle L; Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Biancotto A; Immunology & Inflammation Research Therapeutic Area, Sanofi, Boston, Massachusetts, USA.
Huang Y; Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
Calvo KR; Department of Laboratory Medicine (DLM), Clinical Center/NIH, Bethesda, Maryland, USA.
Marrero B; Computational Systems Biology Section.
Moir S; Laboratory of Immunoregulation, and.
Oler AJ; Bioinformatics and Computational Biosciences Branch (BCBB), Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID/NIH, Bethesda, Maryland, USA.
Deng Z; Biomining and Discovery Section, NIAMS/NIH, Bethesda, Maryland, USA.
Montealegre Sanchez GA; Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
Ahmed A; The Autoinflammatory Diseases Consortium.; Levine Children's Hospital, Charlotte, North Carolina, USA.
Allenspach E; The Autoinflammatory Diseases Consortium.; Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children's Hospital, Seattle, Washington, USA.
Arabshahi B; The Autoinflammatory Diseases Consortium.; Virginia Commonwealth University & Pediatric Specialists of Virginia, Fairfax, Virginia, USA.
Behrens E; The Autoinflammatory Diseases Consortium.; Division of Rheumatology, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Benseler S; The Autoinflammatory Diseases Consortium.; Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children's Hospital, University of Calgary, Calgary, Alberta, Canada.
Bezrodnik L; The Autoinflammatory Diseases Consortium.; Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
Bout-Tabaku S; The Autoinflammatory Diseases Consortium.; Department of Pediatric Medicine, Sidra Medicine, Qatar Foundation, Doha, Qatar.
Brescia AC; The Autoinflammatory Diseases Consortium.; Nemours/Alfred I. DuPont Hospital for Children, Wilmington, Delaware, USA.
Brown D; The Autoinflammatory Diseases Consortium.; Division of Rheumatology, Children's Hospital Los Angeles & USC, Los Angeles, California, USA.
Burnham JM; The Autoinflammatory Diseases Consortium.; Division of Rheumatology, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Caldirola MS; The Autoinflammatory Diseases Consortium.; Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
Carrasco R; The Autoinflammatory Diseases Consortium.; Pediatric Rheumatology, Dell Children's Medical Center of Central Texas, Austin, Texas, USA.
Chan AY; The Autoinflammatory Diseases Consortium.; Divisions of Pediatric AIBMT & Rheumatology, UCSF, San Francisco, California, USA.
Cimaz R; The Autoinflammatory Diseases Consortium.; Department of Clinical Sciences and Community Health, University of Milano, Milan, Italy.
Dancey P; The Autoinflammatory Diseases Consortium.; Division of Rheumatology, Janeway Children's Hospital & Rehabilitation Centre, Saint John's, Newfoundland and Labrador, Canada.
Dare J; The Autoinflammatory Diseases Consortium.; Division of Pediatric Rheumatology, University of Arkansas for Medical Sciences, Arkansas Children's Hospital, Little Rock, Arkansas, USA.
DeGuzman M; The Autoinflammatory Diseases Consortium.; Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, Texas, USA.
Dimitriades V; The Autoinflammatory Diseases Consortium.; Division of Pediatric Allergy, Immunology & Rheumatology, UC Davis Health, Sacramento, California, USA.
Ferguson I; The Autoinflammatory Diseases Consortium.; Department of Pediatrics/Pediatric Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA.
Ferguson P; The Autoinflammatory Diseases Consortium.; Pediatrics Department, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Finn L; The Autoinflammatory Diseases Consortium.; Pathology Department, University of Washington and Seattle Children's Hospital, Seattle, Washington, USA.
Gattorno M; The Autoinflammatory Diseases Consortium.; Center for Autoinflammatory Diseases and Immunedeficiencies, IRCCS Giannina Gaslini, Genoa, Italy.
Grom AA; The Autoinflammatory Diseases Consortium.; Division of Rheumatology, Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Hanson EP; The Autoinflammatory Diseases Consortium.; Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
Hashkes PJ; The Autoinflammatory Diseases Consortium.; Pediatric Rheumatology Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
Hedrich CM; The Autoinflammatory Diseases Consortium.; Department of Women's & Children's Health, Institute of Translational Medicine, University of Liverpool & Department of Paediatric Rheumatology, Alder Hey Children's NHS Foundation Trust Hospital, Liverpool, United Kingdom.
Herzog R; The Autoinflammatory Diseases Consortium.; Department of Otolaryngology, Division of Allergy and Immunology, New York University, New York, New York, USA.
Horneff G; The Autoinflammatory Diseases Consortium.; Asklepios Klinik Sankt, Augustin GmbH, St. Augustin, Germany and Department of Pediatric and Adolescents Medicine, University of Cologne, Cologne, Germany.
Jerath R; The Autoinflammatory Diseases Consortium.; Augusta University Medical Center, Augusta, Georgia, USA.
Kessler E; The Autoinflammatory Diseases Consortium.; Division of Rheumatology, Children's Mercy, Kansas City and University of Missouri, Kansas City, Missouri, USA.
Kim H; The Autoinflammatory Diseases Consortium.; Pediatric Translational Research Branch, NIAMS/NIH, Bethesda, Maryland, USA.
Kingsbury DJ; The Autoinflammatory Diseases Consortium.; Randall Children's Hospital at Legacy Emanuel, Portland, Oregon, USA.
Laxer RM; The Autoinflammatory Diseases Consortium.; Division of Pediatric Rheumatology, University of Toronto and The Hospital for Sick Children, Toronto, Ontario, Canada.
Lee PY; The Autoinflammatory Diseases Consortium.; Division of Allergy, Immunology and Rheumatology, Boston Children's Hospital, Boston, Massachusetts, USA.
Lee-Kirsch MA; The Autoinflammatory Diseases Consortium.; Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Lewandowski L; The Autoinflammatory Diseases Consortium.; Systemic Autoimmunity Branch, NIAMS/NIH, Bethesda, Maryland, USA.
Li S; The Autoinflammatory Diseases Consortium.; Hackensack University Medical Center, Hackensack Meridian School of Medicine at Seton Hall University, Hackensack, New Jersey, USA.
Lilleby V; The Autoinflammatory Diseases Consortium.; Department of Rheumatology, Pediatric Section, Oslo University Hospital, Oslo, Norway.
Mammadova V; The Autoinflammatory Diseases Consortium.; Azerbaijan Medical University, Baku, Azerbaijan.
Moorthy LN; The Autoinflammatory Diseases Consortium.; Rutgers - Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
Nasrullayeva G; The Autoinflammatory Diseases Consortium.; Azerbaijan Medical University, Baku, Azerbaijan.
O'Neil KM; The Autoinflammatory Diseases Consortium.; Department of Pediatrics Indiana University School of Medicine and Riley Hospital for Children, Indianapolis, Indiana, USA.
Onel K; The Autoinflammatory Diseases Consortium.; Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
Ozen S; The Autoinflammatory Diseases Consortium.; Hacettepe University, Department of Pediatrics, Ankara, Turkey.
Pan N; The Autoinflammatory Diseases Consortium.; Division of Pediatric Rheumatology, Weill Cornell Medicine & Hospital for Special Surgery, New York, New York, USA.
Pillet P; The Autoinflammatory Diseases Consortium.; Children Hospital Pellegrin-Enfants, Bordeaux, France.
Piotto DG; The Autoinflammatory Diseases Consortium.; Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
Punaro MG; The Autoinflammatory Diseases Consortium.; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Reiff A; The Autoinflammatory Diseases Consortium.; Division of Rheumatology, Children's Hospital Los Angeles, Keck School of Medicine, USC, Los Angeles, California, USA.
Reinhardt A; The Autoinflammatory Diseases Consortium.; University of Nebraska Medical Center/Children's Hospital and Medical Center, Omaha, Nebraska, USA.
Rider LG; The Autoinflammatory Diseases Consortium.; Environmental Autoimmunity Group, NIEHS/NIH, Bethesda, Maryland, USA.
Rivas-Chacon R; The Autoinflammatory Diseases Consortium.; Department of Pediatric Rheumatology, Nicklaus Children's Hospital, Miami, Florida, USA.
Ronis T; The Autoinflammatory Diseases Consortium.; Division of Pediatric Rheumatology, Children's National Health System, Washington, DC, USA.
Rösen-Wolff A; The Autoinflammatory Diseases Consortium.; Department of Pediatrics, Medizinische Fakultät Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Roth J; The Autoinflammatory Diseases Consortium.; Division of Pediatric Dermatology and Rheumatology, Children's Hospital of Eastern Ontario, Ottawa, Canada.
Ruth NM; The Autoinflammatory Diseases Consortium.; Medical University of South Carolina, Charleston, South Carolina, USA.
Rygg M; The Autoinflammatory Diseases Consortium.; Department of Clinical and Molecular Medicine, NTNU - Norwegian University of Science and Technology, and Department of Pediatrics, St. Olavs Hospital, Trondheim, Norway.
Schmeling H; The Autoinflammatory Diseases Consortium.; Department of Pediatrics, Pediatric Rheumatology Section, Alberta Children's Hospital, University of Calgary, Calgary, Alberta, Canada.
Schulert G; The Autoinflammatory Diseases Consortium.; Division of Rheumatology, Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Scott C; The Autoinflammatory Diseases Consortium.; University of Cape Town, Red Cross War Memorial Children's Hospital, Cape Town, South Africa.
Seminario G; The Autoinflammatory Diseases Consortium.; Immunology Unit, Pediatric Hospital R. Gutierrez, Buenos Aires, Argentina.
Shulman A; The Autoinflammatory Diseases Consortium.; Pediatric Rheumatology, Children's Hospital of Orange County, UC Irvine, Irvine, California, USA.
Sivaraman V; The Autoinflammatory Diseases Consortium.; Section of Rheumatology, Nationwide Children's Hospital, Columbus, Ohio, USA.
Son MB; The Autoinflammatory Diseases Consortium.; Division of Immunology, Boston Children's Hospital, Boston, Massachusetts, USA.
Stepanovskiy Y; The Autoinflammatory Diseases Consortium.; Department of Pediatric Infectious Diseases and Immunology, Shupyk National Medical Academy for Postgraduate Education, Kiev, Ukraine.
Stringer E; The Autoinflammatory Diseases Consortium.; IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
Taber S; The Autoinflammatory Diseases Consortium.; Division of Pediatric Rheumatology, Department of Rheumatology, Hospital for Special Surgery, New York, New York, USA.
Terreri MT; The Autoinflammatory Diseases Consortium.; Department of Pediatric Rheumatology, Federal University of Sao Paulo, Sao Paulo, Brazil.
Tifft C; The Autoinflammatory Diseases Consortium.; Undiagnosed Diseases Program, NHGRI/NIH, Bethesda, Maryland, USA.
Torgerson T; The Autoinflammatory Diseases Consortium.; Divisions of Immunology & Rheumatology, Department of Pediatrics, University of Washington and Seattle Children's Hospital, Seattle, Washington, USA.
Tosi L; The Autoinflammatory Diseases Consortium.; Bone Health Program, Children's National Health System, Washington, DC, USA.
Van Royen-Kerkhof A; The Autoinflammatory Diseases Consortium.; Department of Pediatric Immunology and Rheumatology, Wilhelmina Children's Hospital Utrecht, Utrecht, Netherlands.
Wampler Muskardin T; The Autoinflammatory Diseases Consortium.; New York University School of Medicine, New York, New York, USA.
Canna SW; Children's Hospital Pittsburgh, Pittsburgh, Pennsylvania, USA.
Goldbach-Mansky R; Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, Maryland, USA.
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Źródło :
The Journal of clinical investigation [J Clin Invest] 2020 Apr 01; Vol. 130 (4), pp. 1669-1682.
Typ publikacji :
Clinical Trial; Journal Article; Multicenter Study; Research Support, N.I.H., Intramural
MeSH Terms :
Autoimmune Diseases*/genetics
Autoimmune Diseases*/immunology
Interferon Type I*/genetics
Interferon Type I*/immunology
Interleukin-18*/genetics
Interleukin-18*/immunology
Macrophage Activation Syndrome*/genetics
Macrophage Activation Syndrome*/immunology
Mutation*
Panniculitis*/genetics
Panniculitis*/immunology
Pulmonary Alveolar Proteinosis*/genetics
Pulmonary Alveolar Proteinosis*/immunology
Female ; Humans ; Male
SCR Disease Name :
Pulmonary Alveolar Proteinosis, Acquired
Czasopismo naukowe
Tytuł :
IL-18 as a biomarker linking systemic juvenile idiopathic arthritis and macrophage activation syndrome.
Autorzy :
Yasin S; Division of Rheumatology, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH.
Fall N; Division of Rheumatology, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH.
Brown RA; Division of Rheumatology, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH.
Henderlight M; Division of Rheumatology, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH.
Canna SW; Pediatric Rheumatology & Immunology, Children's Hospital of Pittsburgh/UPMC, Pittsburgh, PA, USA.
Girard-Guyonvarc'h C; Rheumatology, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.
Gabay C; Rheumatology, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.
Grom AA; Division of Rheumatology, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH.
Schulert GS; Division of Rheumatology, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH.
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Źródło :
Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2020 Feb 01; Vol. 59 (2), pp. 361-366.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Arthritis, Juvenile/*diagnosis
Interleukin-18/*blood
Macrophage Activation Syndrome/*diagnosis
Arthritis, Juvenile/blood ; Biomarkers/blood ; Chemokine CXCL9/blood ; Female ; Ferritins/blood ; Humans ; Macrophage Activation Syndrome/blood ; Male ; S100 Proteins/blood ; Severity of Illness Index
Czasopismo naukowe
Tytuł :
A novel de novo NLRC4 mutation reinforces the likely pathogenicity of specific LRR domain mutation.
Autorzy :
Chear CT; Primary Immunodeficiency Unit, Allergy and Immunology Research Centre, Institute for Medical Research, Ministry of Health, Malaysia; Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia.
Nallusamy R; Pediatric Department, Penang General Hospital, Ministry of Health, Malaysia.
Canna SW; Pediatrics and Immunology, University of Pittsburgh, Pittsburgh, PA, USA.
Chan KC; Pediatric Department, Penang General Hospital, Ministry of Health, Malaysia.
Baharin MF; Primary Immunodeficiency Unit, Allergy and Immunology Research Centre, Institute for Medical Research, Ministry of Health, Malaysia.
Hishamshah M; Primary Immunodeficiency Unit, Allergy and Immunology Research Centre, Institute for Medical Research, Ministry of Health, Malaysia.
Ghani H; Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia.
Ripen AM; Primary Immunodeficiency Unit, Allergy and Immunology Research Centre, Institute for Medical Research, Ministry of Health, Malaysia.
Mohamad SB; Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia; Centre of Research in Systems Biology, Structural Bioinformatics and Human Digital Imaging (CRYSTAL), University of Malaya, Kuala Lumpur, Malaysia. Electronic address: .
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Źródło :
Clinical immunology (Orlando, Fla.) [Clin Immunol] 2020 Feb; Vol. 211, pp. 108328. Date of Electronic Publication: 2019 Dec 20.
Typ publikacji :
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autoimmune Diseases/*genetics
CARD Signaling Adaptor Proteins/*genetics
Calcium-Binding Proteins/*genetics
Arthritis/genetics ; Chemokine CXCL9/blood ; Child ; Erythema/blood ; Female ; Fever/genetics ; Humans ; Interleukin-18/blood ; Mutation ; Protein Domains ; Syndrome
Czasopismo naukowe

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