Temat: "Cannabinoid" - OpacWWW

Skocz do pozycji: 1 1.

Tytuł :: Mechanisms for the Risk of Acute Coronary Syndrome and Arrhythmia Associated With Phytogenic and Synthetic Cannabinoid Use.
Autorzy :: Richards JR; Department of Emergency Medicine, 70083University of California Davis Medical Center, Sacramento, California, CA, USA.; Pokaż więcej
Źródło :: Journal of cardiovascular pharmacology and therapeutics [J Cardiovasc Pharmacol Ther] 2020 Nov; Vol. 25 (6), pp. 508-522. Date of Electronic Publication: 2020 Jun 26.
Typ publikacji :: Journal Article; Review
MeSH Terms :: Acute Coronary Syndrome/*chemically induced
Arrhythmias, Cardiac/*chemically induced
Cannabinoid Receptor Agonists/*adverse effects
Cannabinoids/*adverse effects
Cannabis/*adverse effects
Heart/*drug effects
Marijuana Abuse/*complications
Marijuana Smoking/*adverse effects
Acute Coronary Syndrome/physiopathology ; Animals ; Arrhythmias, Cardiac/physiopathology ; Cannabinoid Receptor Agonists/chemical synthesis ; Cannabinoid Receptor Agonists/isolation & purification ; Cannabinoids/chemical synthesis ; Cannabinoids/isolation & purification ; Cannabis/chemistry ; Cardiotoxicity ; Heart/physiopathology ; Heart Rate/drug effects ; Humans ; Receptors, Cannabinoid/drug effects ; Risk Assessment ; Risk Factors ; Signal Transduction
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 2 2.

Tytuł :: Dipyrone is locally hydrolyzed to 4-methylaminoantipyrine and its antihyperalgesic effect depends on CB 2 and kappa-opioid receptors activation.
Autorzy :: Gonçalves Dos Santos G; Department of Structural and Functional Biology, Institute of Biology, University of Campinas (UNICAMP), 13083-864, Campinas, Sao Paulo, Brazil. Electronic address: .
Vieira WF; Department of Structural and Functional Biology, Institute of Biology, University of Campinas (UNICAMP), 13083-864, Campinas, Sao Paulo, Brazil. Electronic address: .
Vendramini PH; Thomson Mass Spectrometry Laboratory, Institute of Chemistry, University of Campinas (UNICAMP), 13083-970, Campinas, Sao Paulo, Brazil. Electronic address: .
Bassani da Silva B; Department of Structural and Functional Biology, Institute of Biology, University of Campinas (UNICAMP), 13083-864, Campinas, Sao Paulo, Brazil. Electronic address: .
Fernandes Magalhães S; Department of Structural and Functional Biology, Institute of Biology, University of Campinas (UNICAMP), 13083-864, Campinas, Sao Paulo, Brazil. Electronic address: .
Tambeli CH; Department of Structural and Functional Biology, Institute of Biology, University of Campinas (UNICAMP), 13083-864, Campinas, Sao Paulo, Brazil. Electronic address: .
Parada CA; Department of Structural and Functional Biology, Institute of Biology, University of Campinas (UNICAMP), 13083-864, Campinas, Sao Paulo, Brazil. Electronic address: .; Pokaż więcej
Źródło :: European journal of pharmacology [Eur J Pharmacol] 2020 May 05; Vol. 874, pp. 173005. Date of Electronic Publication: 2020 Feb 11.
Typ publikacji :: Journal Article
MeSH Terms :: Receptor, Cannabinoid, CB2*/antagonists & inhibitors
Receptors, Opioid, kappa*/antagonists & inhibitors
Analgesics/*pharmacology
Analgesics/*therapeutic use
Dipyrone/*pharmacology
Dipyrone/*therapeutic use
Hyperalgesia/*drug therapy
Animals ; Cannabinoid Receptor Antagonists/pharmacology ; Carrageenan ; Dipyrone/analogs & derivatives ; Hydrolysis ; Hyperalgesia/metabolism ; Indoles/pharmacology ; Male ; Naloxone/pharmacology ; Naltrexone/analogs & derivatives ; Naltrexone/pharmacology ; Narcotic Antagonists/pharmacology ; Rats, Wistar ; Somatostatin/analogs & derivatives ; Somatostatin/pharmacology
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 3 3.

Tytuł :: Developmentally Transient CB1Rs on Cerebellar Afferents Suppress Afferent Input, Downstream Synaptic Excitation, and Signaling to Migrating Neurons.
Autorzy :: Barnes JL; Washington State University, Integrative Physiology and Neuroscience, Pullman, Washington 99164.
Mohr C; Washington State University, Integrative Physiology and Neuroscience, Pullman, Washington 99164.
Ritchey CR; Washington State University, Integrative Physiology and Neuroscience, Pullman, Washington 99164.
Erikson CM; Washington State University, Integrative Physiology and Neuroscience, Pullman, Washington 99164.
Shiina H; Washington State University, Integrative Physiology and Neuroscience, Pullman, Washington 99164.
Rossi DJ; Washington State University, Integrative Physiology and Neuroscience, Pullman, Washington 99164 .; Pokaż więcej
Źródło :: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2020 Aug 05; Vol. 40 (32), pp. 6133-6145. Date of Electronic Publication: 2020 Jul 06.
Typ publikacji :: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :: Excitatory Postsynaptic Potentials*
Neurogenesis*
Neurons, Afferent/*metabolism
Purkinje Cells/*metabolism
Receptor, Cannabinoid, CB1/*metabolism
Action Potentials ; Animals ; Cannabinoid Receptor Antagonists/pharmacology ; Cell Movement ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Neurons, Afferent/drug effects ; Neurons, Afferent/physiology ; Purkinje Cells/drug effects ; Purkinje Cells/physiology ; Receptor, Cannabinoid, CB1/antagonists & inhibitors ; Receptor, Cannabinoid, CB1/genetics ; Synapses/metabolism ; Synapses/physiology
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 4 4.

Tytuł :: Antiemetic Effects of Cannabinoid Agonists in Nonhuman Primates.
Autorzy :: Wooldridge LM; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts (J.B., B.D.K.); Behavioral Biology Program, McLean Hospital, Belmont, Massachusetts (L.M.W., J.B., B.D.K.); and Center for Drug Discovery, Northeastern University, Boston, Massachusetts (L.J., Y.L., S.P.N., A.M.).
Ji L; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts (J.B., B.D.K.); Behavioral Biology Program, McLean Hospital, Belmont, Massachusetts (L.M.W., J.B., B.D.K.); and Center for Drug Discovery, Northeastern University, Boston, Massachusetts (L.J., Y.L., S.P.N., A.M.).
Liu Y; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts (J.B., B.D.K.); Behavioral Biology Program, McLean Hospital, Belmont, Massachusetts (L.M.W., J.B., B.D.K.); and Center for Drug Discovery, Northeastern University, Boston, Massachusetts (L.J., Y.L., S.P.N., A.M.).
Nikas SP; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts (J.B., B.D.K.); Behavioral Biology Program, McLean Hospital, Belmont, Massachusetts (L.M.W., J.B., B.D.K.); and Center for Drug Discovery, Northeastern University, Boston, Massachusetts (L.J., Y.L., S.P.N., A.M.).
Makriyannis A; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts (J.B., B.D.K.); Behavioral Biology Program, McLean Hospital, Belmont, Massachusetts (L.M.W., J.B., B.D.K.); and Center for Drug Discovery, Northeastern University, Boston, Massachusetts (L.J., Y.L., S.P.N., A.M.).
Bergman J; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts (J.B., B.D.K.); Behavioral Biology Program, McLean Hospital, Belmont, Massachusetts (L.M.W., J.B., B.D.K.); and Center for Drug Discovery, Northeastern University, Boston, Massachusetts (L.J., Y.L., S.P.N., A.M.).
Kangas BD; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts (J.B., B.D.K.); Behavioral Biology Program, McLean Hospital, Belmont, Massachusetts (L.M.W., J.B., B.D.K.); and Center for Drug Discovery, Northeastern University, Boston, Massachusetts (L.J., Y.L., S.P.N., A.M.) .; Pokaż więcej
Źródło :: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2020 Sep; Vol. 374 (3), pp. 462-468. Date of Electronic Publication: 2020 Jun 19.
Typ publikacji :: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :: Antiemetics/*pharmacology
Cannabinoid Receptor Agonists/*pharmacology
Animals ; Antiemetics/therapeutic use ; Arachidonic Acids/pharmacology ; Arachidonic Acids/therapeutic use ; Cannabinoid Receptor Agonists/therapeutic use ; Dronabinol/pharmacology ; Dronabinol/therapeutic use ; Drug Interactions ; Male ; Receptor, Cannabinoid, CB1/agonists ; Saimiri ; Salivation/drug effects ; Vomiting/drug therapy
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 5 5.

Tytuł :: Allosteric Modulation of Cannabinoid Receptor 1-Current Challenges and Future Opportunities.
Autorzy :: Hryhorowicz S; Institute of Human Genetics, Polish Academy of Sciences, Strzeszyńska 32, 60-479 Poznań, Poland.
Kaczmarek-Ryś M; Institute of Human Genetics, Polish Academy of Sciences, Strzeszyńska 32, 60-479 Poznań, Poland.
Andrzejewska A; Department of Structure and Function of Retrotransposons, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704 Poznań, Poland.
Staszak K; Department of Integrative Genomics, Institute of Anthropology, Adam Mickiewicz University, Uniwersytetu Poznańskiego 6, 61-614 Poznań, Poland.
Hryhorowicz M; Department of Biochemistry and Biotechnology, University of Life Sciences, Dojazd 11, 60-632 Poznań, Poland.
Korcz A; Institute of Human Genetics, Polish Academy of Sciences, Strzeszyńska 32, 60-479 Poznań, Poland.
Słomski R; Institute of Human Genetics, Polish Academy of Sciences, Strzeszyńska 32, 60-479 Poznań, Poland.; Department of Biochemistry and Biotechnology, University of Life Sciences, Dojazd 11, 60-632 Poznań, Poland.; Pokaż więcej
Źródło :: International journal of molecular sciences [Int J Mol Sci] 2019 Nov 22; Vol. 20 (23). Date of Electronic Publication: 2019 Nov 22.
Typ publikacji :: Journal Article; Review
MeSH Terms :: Receptor, Cannabinoid, CB1*/chemistry
Receptor, Cannabinoid, CB1*/genetics
Receptor, Cannabinoid, CB1*/metabolism
Cannabinoid Receptor Agonists/*chemistry
Allosteric Regulation ; Animals ; Cannabinoid Receptor Agonists/therapeutic use ; Crystallography, X-Ray ; Humans ; Mutagenesis, Site-Directed ; Neurodegenerative Diseases/drug therapy ; Neurodegenerative Diseases/genetics ; Neurodegenerative Diseases/metabolism ; Pain/drug therapy ; Pain/genetics ; Pain/metabolism ; Structure-Activity Relationship ; Substance-Related Disorders/drug therapy ; Substance-Related Disorders/genetics ; Substance-Related Disorders/metabolism
: Czasopismo naukowe

Szczegóły Pełny tekst Pełny tekst

Skocz do pozycji: 6 6.

Tytuł :: Design, Synthesis, and Physicochemical and Pharmacological Profiling of 7-Hydroxy-5-oxopyrazolo[4,3- b ]pyridine-6-carboxamide Derivatives with Antiosteoarthritic Activity In Vivo.
Autorzy :: Mugnaini C; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.
Kostrzewa M; Endocannabinoid Research Group, Institute of Biomolecular Chemistry, National Research Council of Italy, Via Campi Flegrei 34, 80078 Pozzuoli, Napoli, Italy.; Institute of Genetics and Biophysics, National Research Council of Italy, Via Pietro Castellino 111, 80131 Napoli, Italy.
Bryk M; Institute of Genetics and Biophysics, National Research Council of Italy, Via Pietro Castellino 111, 80131 Napoli, Italy.
Mahmoud AM; Endocannabinoid Research Group, Institute of Biomolecular Chemistry, National Research Council of Italy, Via Campi Flegrei 34, 80078 Pozzuoli, Napoli, Italy.
Brizzi A; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.
Lamponi S; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.
Giorgi G; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.
Ferlenghi F; Department of Food and Drug, University of Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy.
Vacondio F; Department of Food and Drug, University of Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy.
Maccioni P; Institute of Neuroscience, National Research Council of Italy, S.S. 554, km 4,500, 09042 Monserrato, Cagliari, Italy.
Colombo G; Institute of Neuroscience, National Research Council of Italy, S.S. 554, km 4,500, 09042 Monserrato, Cagliari, Italy.
Mor M; Department of Food and Drug, University of Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy.
Starowicz K; Department of Neurochemistry, Institute of Pharmacology, Polish Academy of Sciences, ul. Smetna 12, 31-343 Cracow, Poland.
Di Marzo V; Endocannabinoid Research Group, Institute of Biomolecular Chemistry, National Research Council of Italy, Via Campi Flegrei 34, 80078 Pozzuoli, Napoli, Italy.
Ligresti A; Endocannabinoid Research Group, Institute of Biomolecular Chemistry, National Research Council of Italy, Via Campi Flegrei 34, 80078 Pozzuoli, Napoli, Italy.
Corelli F; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.; Pokaż więcej
Źródło :: Journal of medicinal chemistry [J Med Chem] 2020 Jul 09; Vol. 63 (13), pp. 7369-7391. Date of Electronic Publication: 2020 Jun 22.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Anti-Asthmatic Agents/*pharmacology
Chondrocytes/*drug effects
Osteoarthritis/*drug therapy
Receptor, Cannabinoid, CB2/*metabolism
4-Quinolones/chemistry ; Animals ; Anti-Asthmatic Agents/chemistry ; CHO Cells ; Cannabinoid Receptor Agonists/chemical synthesis ; Cannabinoid Receptor Agonists/pharmacology ; Chondrocytes/metabolism ; Chondrocytes/pathology ; Colforsin/pharmacology ; Cricetulus ; Disease Models, Animal ; Drug Design ; Drug Evaluation, Preclinical/methods ; Humans ; Iodoacetic Acid/toxicity ; Ligands ; Male ; Mice ; NIH 3T3 Cells ; Osteoarthritis/chemically induced ; Rats, Wistar ; Receptor, Cannabinoid, CB1/genetics ; Receptor, Cannabinoid, CB1/metabolism ; Receptor, Cannabinoid, CB2/agonists ; Receptor, Cannabinoid, CB2/antagonists & inhibitors ; Receptor, Cannabinoid, CB2/genetics ; Structure-Activity Relationship ; Walking
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 7 7.

Tytuł :: Effects of combined 5-HT 2A and cannabinoid receptor modulation on a schizophrenia-related prepulse inhibition deficit in mice.
Autorzy :: Marques AM; Laboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Av. Carlos Chagas Filho, 373, bloco J, sala J1-029, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, CEP 21941-902, Brazil.; Graduate Program in Pharmacology and Medicinal Chemistry, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Macena MV; Laboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Av. Carlos Chagas Filho, 373, bloco J, sala J1-029, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, CEP 21941-902, Brazil.
Cardoso AR; Laboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Av. Carlos Chagas Filho, 373, bloco J, sala J1-029, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, CEP 21941-902, Brazil.
Hammes CSO; Laboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Av. Carlos Chagas Filho, 373, bloco J, sala J1-029, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, CEP 21941-902, Brazil.
Pinheiro FML; Laboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Av. Carlos Chagas Filho, 373, bloco J, sala J1-029, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, CEP 21941-902, Brazil.
Castro NG; Laboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Av. Carlos Chagas Filho, 373, bloco J, sala J1-029, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, CEP 21941-902, Brazil.; Graduate Program in Pharmacology and Medicinal Chemistry, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Neves GA; Laboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Av. Carlos Chagas Filho, 373, bloco J, sala J1-029, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, CEP 21941-902, Brazil. .; Graduate Program in Pharmacology and Medicinal Chemistry, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil. .; Pokaż więcej
Źródło :: Psychopharmacology [Psychopharmacology (Berl)] 2020 Jun; Vol. 237 (6), pp. 1643-1655. Date of Electronic Publication: 2020 Feb 24.
Typ publikacji :: Journal Article
MeSH Terms :: Cannabinoid Receptor Antagonists/*administration & dosage
Prepulse Inhibition/*physiology
Receptor, Serotonin, 5-HT2A/*physiology
Receptors, Cannabinoid/*physiology
Schizophrenia/*drug therapy
Serotonin 5-HT2 Receptor Antagonists/*administration & dosage
8-Hydroxy-2-(di-n-propylamino)tetralin/administration & dosage ; Animals ; Benzoxazines/administration & dosage ; Cannabinoid Receptor Modulators/administration & dosage ; Cannabinoids/administration & dosage ; Dose-Response Relationship, Drug ; Drug Therapy, Combination ; Fluorobenzenes/administration & dosage ; Male ; Mice ; Morpholines/administration & dosage ; Naphthalenes/administration & dosage ; Piperidines/administration & dosage ; Prepulse Inhibition/drug effects ; Reflex, Startle/drug effects ; Reflex, Startle/physiology ; Serotonin 5-HT2 Receptor Agonists/administration & dosage ; Treatment Outcome
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 8 8.

Tytuł :: Innovative Therapeutic Potential of Cannabinoid Receptors as Targets in Alzheimer's Disease and Less Well-Known Diseases.
Autorzy :: Páez JA; Instituto de Quimica Medica (IQM-CSIC). C/ Juan de la Cierva, 3, 28006, Madrid, Spain.
Campillo NE; Centro de Investigaciones Biologicas (CIB-CSIC). C/ Ramiro de Maeztu, 9, 28040, Madrid, Spain.; Pokaż więcej
Źródło :: Current medicinal chemistry [Curr Med Chem] 2019; Vol. 26 (18), pp. 3300-3340.
Typ publikacji :: Journal Article; Review
MeSH Terms :: Cannabinoid Receptor Agonists*/chemistry
Cannabinoid Receptor Agonists*/pharmacology
Cannabinoid Receptor Agonists*/therapeutic use
Alzheimer Disease/*drug therapy
Receptors, Cannabinoid/*metabolism
Alzheimer Disease/metabolism ; Animals ; Arachidonic Acids/chemistry ; Arachidonic Acids/pharmacology ; Arachidonic Acids/therapeutic use ; Autism Spectrum Disorder/drug therapy ; Bone Diseases/drug therapy ; Cardiovascular Diseases/drug therapy ; Drug Discovery ; Endocannabinoids/chemistry ; Endocannabinoids/pharmacology ; Endocannabinoids/therapeutic use ; Fragile X Syndrome/drug therapy ; Humans ; Molecular Targeted Therapy ; Multiple Sclerosis/drug therapy ; Polyunsaturated Alkamides/chemistry ; Polyunsaturated Alkamides/pharmacology ; Polyunsaturated Alkamides/therapeutic use ; Receptor, Cannabinoid, CB2/metabolism
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 9 9.

Tytuł :: Glucose metabolism links astroglial mitochondria to cannabinoid effects.
Autorzy :: Jimenez-Blasco D; Institute of Functional Biology and Genomics, University of Salamanca, CSIC, Salamanca, Spain.; Centro de Investigación Biomédica en Red sobre Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain.; Institute of Biomedical Research of Salamanca, University Hospital of Salamanca, University of Salamanca, CSIC, Salamanca, Spain.
Busquets-Garcia A; INSERM, U1215 NeuroCentre Magendie, Bordeaux, France.; University of Bordeaux, Bordeaux, France.; Integrative Pharmacology and Systems Neuroscience, IMIM Hospital del Mar Medical Research Institute, Barcelona, Spain.
Hebert-Chatelain E; Canada Research Chair in Mitochondrial Signaling and Physiopathology, Université de Moncton, Moncton, New Brunswick, Canada.; Department of Biology, Université de Moncton, Moncton, New Brunswick, Canada.
Serrat R; INSERM, U1215 NeuroCentre Magendie, Bordeaux, France.; University of Bordeaux, Bordeaux, France.
Vicente-Gutierrez C; Institute of Functional Biology and Genomics, University of Salamanca, CSIC, Salamanca, Spain.; Centro de Investigación Biomédica en Red sobre Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain.; Institute of Biomedical Research of Salamanca, University Hospital of Salamanca, University of Salamanca, CSIC, Salamanca, Spain.
Ioannidou C; INSERM, U1215 NeuroCentre Magendie, Bordeaux, France.; University of Bordeaux, Bordeaux, France.
Gómez-Sotres P; INSERM, U1215 NeuroCentre Magendie, Bordeaux, France.; University of Bordeaux, Bordeaux, France.
Lopez-Fabuel I; Institute of Functional Biology and Genomics, University of Salamanca, CSIC, Salamanca, Spain.; Centro de Investigación Biomédica en Red sobre Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain.; Institute of Biomedical Research of Salamanca, University Hospital of Salamanca, University of Salamanca, CSIC, Salamanca, Spain.
Resch-Beusher M; Institute of Functional Biology and Genomics, University of Salamanca, CSIC, Salamanca, Spain.; Centro de Investigación Biomédica en Red sobre Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain.; Institute of Biomedical Research of Salamanca, University Hospital of Salamanca, University of Salamanca, CSIC, Salamanca, Spain.
Resel E; Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Instituto Universitario de Investigación Neuroquímica (IUIN) and Department of Biochemistry and Molecular Biology, Complutense University, Madrid, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
Arnouil D; INSERM, U1215 NeuroCentre Magendie, Bordeaux, France.; University of Bordeaux, Bordeaux, France.
Saraswat D; INSERM, U1215 NeuroCentre Magendie, Bordeaux, France.; University of Bordeaux, Bordeaux, France.
Varilh M; INSERM, U1215 NeuroCentre Magendie, Bordeaux, France.; University of Bordeaux, Bordeaux, France.
Cannich A; INSERM, U1215 NeuroCentre Magendie, Bordeaux, France.; University of Bordeaux, Bordeaux, France.
Julio-Kalajzic F; INSERM, U1215 NeuroCentre Magendie, Bordeaux, France.; University of Bordeaux, Bordeaux, France.
Bonilla-Del Río I; Department of Neurosciences, University of the Basque Country (UPV/EHU), Leioa, Spain.; Achucarro Basque Center for Neuroscience, Science Park of the UPV/EHU, Leioa, Spain.
Almeida A; Institute of Functional Biology and Genomics, University of Salamanca, CSIC, Salamanca, Spain.; Institute of Biomedical Research of Salamanca, University Hospital of Salamanca, University of Salamanca, CSIC, Salamanca, Spain.
Puente N; Department of Neurosciences, University of the Basque Country (UPV/EHU), Leioa, Spain.; Achucarro Basque Center for Neuroscience, Science Park of the UPV/EHU, Leioa, Spain.
Achicallende S; Department of Neurosciences, University of the Basque Country (UPV/EHU), Leioa, Spain.; Achucarro Basque Center for Neuroscience, Science Park of the UPV/EHU, Leioa, Spain.
Lopez-Rodriguez ML; Department of Organic Chemistry, Complutense University, Madrid, Spain.
Jollé C; Department of Physiology, University of Lausanne, Lausanne, Switzerland.
Déglon N; Department of Clinical Neurosciences, Laboratory of Cellular and Molecular Neurotherapies (LCMN), University of Lausanne, Lausanne, Switzerland.
Pellerin L; Department of Physiology, University of Lausanne, Lausanne, Switzerland.; Centre de Résonance Magnétique des Systèmes Biologiques UMR 5536, CNRS-University of Bordeaux, Bordeaux, France.; INSERM U1082, University of Poitiers, Poitiers, France.
Josephine C; Université Paris-Saclay, CEA, CNRS, MIRCen, Laboratoire des Maladies Neurodégénératives, Fontenay-aux-Roses, France.
Bonvento G; Université Paris-Saclay, CEA, CNRS, MIRCen, Laboratoire des Maladies Neurodégénératives, Fontenay-aux-Roses, France.
Panatier A; INSERM, U1215 NeuroCentre Magendie, Bordeaux, France.; University of Bordeaux, Bordeaux, France.
Lutz B; Institute of Physiological Chemistry, University Medical Center, Mainz, Germany.; Leibniz Institute for Resilience Research (LIR), Mainz, Germany.
Piazza PV; INSERM, U1215 NeuroCentre Magendie, Bordeaux, France.; University of Bordeaux, Bordeaux, France.; Aelis Farma, Bordeaux, France.
Guzmán M; Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Instituto Universitario de Investigación Neuroquímica (IUIN) and Department of Biochemistry and Molecular Biology, Complutense University, Madrid, Spain.; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
Bellocchio L; INSERM, U1215 NeuroCentre Magendie, Bordeaux, France.; University of Bordeaux, Bordeaux, France.
Bouzier-Sore AK; Centre de Résonance Magnétique des Systèmes Biologiques UMR 5536, CNRS-University of Bordeaux, Bordeaux, France.
Grandes P; Department of Neurosciences, University of the Basque Country (UPV/EHU), Leioa, Spain.; Achucarro Basque Center for Neuroscience, Science Park of the UPV/EHU, Leioa, Spain.; Division of Medical Sciences, University of Victoria, Victoria, British Columbia, Canada.
Bolaños JP; Institute of Functional Biology and Genomics, University of Salamanca, CSIC, Salamanca, Spain. .; Centro de Investigación Biomédica en Red sobre Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain. .; Institute of Biomedical Research of Salamanca, University Hospital of Salamanca, University of Salamanca, CSIC, Salamanca, Spain. .
Marsicano G; INSERM, U1215 NeuroCentre Magendie, Bordeaux, France. .; University of Bordeaux, Bordeaux, France. .; Pokaż więcej
Źródło :: Nature [Nature] 2020 Jul; Vol. 583 (7817), pp. 603-608. Date of Electronic Publication: 2020 Jul 08.
Typ publikacji :: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :: Energy Metabolism*/drug effects
Astrocytes/*metabolism
Glucose/*metabolism
Mitochondria/*metabolism
Receptor, Cannabinoid, CB1/*metabolism
Animals ; Astrocytes/cytology ; Astrocytes/drug effects ; Cannabinoid Receptor Agonists/pharmacology ; Cells, Cultured ; Dronabinol/pharmacology ; Electron Transport Complex I/chemistry ; Electron Transport Complex I/metabolism ; Glycolysis/drug effects ; Humans ; Hypoxia-Inducible Factor 1/metabolism ; Lactic Acid/metabolism ; Male ; Mice ; Mitochondria/drug effects ; Mitochondrial Membranes/metabolism ; Oxidation-Reduction ; Phosphorylation ; Reactive Oxygen Species/metabolism ; Receptor, Cannabinoid, CB1/agonists ; Social Behavior
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 10 10.

Tytuł :: In vivo evaluation of the CB 1 allosteric modulator LDK1258 reveals CB 1 -receptor independent behavioral effects.
Autorzy :: Mustafa M; Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA.
Donvito G; Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA.
Moncayo L; Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA.
Swafford A; Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA.
Poklis J; Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA.
Grauer R; Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA.
Olszewska T; Rangel College of Pharmacy, Health Science Center, Texas A&M University, Kingsville, TX, USA.
Ignatowska-Jankowska B; Rangel College of Pharmacy, Health Science Center, Texas A&M University, Kingsville, TX, USA.
Kendall DA; Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, USA.
Lu D; Rangel College of Pharmacy, Health Science Center, Texas A&M University, Kingsville, TX, USA.
Lichtman AH; Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA; Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA, USA. Electronic address: .; Pokaż więcej
Źródło :: Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 2020 Mar; Vol. 190, pp. 172840. Date of Electronic Publication: 2019 Dec 30.
Typ publikacji :: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :: Analgesics/*pharmacology
Appetite Depressants/*pharmacology
Behavior, Animal/*drug effects
Locomotion/*drug effects
Neuralgia/*drug therapy
Receptor, Cannabinoid, CB1/*metabolism
Allosteric Regulation ; Amidohydrolases/genetics ; Animals ; Arachidonic Acids/pharmacology ; Cannabinoid Receptor Agonists/pharmacology ; Cannabinoid Receptor Antagonists/pharmacology ; Chromatography, Liquid ; Cyclohexanols/pharmacology ; Disease Models, Animal ; Endocannabinoids/pharmacology ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Polyunsaturated Alkamides/pharmacology ; Receptor, Cannabinoid, CB1/genetics ; Rimonabant/pharmacology ; Tandem Mass Spectrometry
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 11 11.

Tytuł :: Cryo-EM Structure of the Human Cannabinoid Receptor CB2-G i Signaling Complex.
Autorzy :: Xing C; Department of Pharmaceutical Sciences, Computational Chemical Genomics Screen Center, School of Pharmacy, and NIDA National Center of Excellence for Computational Drug Abuse Research, University of Pittsburgh, Pittsburgh, PA 15261, USA; Drug Discovery Institute and Departments of Computational Biology and of Structural Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Zhuang Y; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of the Chinese Academy of Sciences, Beijing 100049, China; Center for Cancer and Cell Biology, Program for Structural Biology, Van Andel Institute, Grand Rapids, MI 49503, USA.
Xu TH; Center for Cancer and Cell Biology, Program for Structural Biology, Van Andel Institute, Grand Rapids, MI 49503, USA.
Feng Z; Department of Pharmaceutical Sciences, Computational Chemical Genomics Screen Center, School of Pharmacy, and NIDA National Center of Excellence for Computational Drug Abuse Research, University of Pittsburgh, Pittsburgh, PA 15261, USA; Drug Discovery Institute and Departments of Computational Biology and of Structural Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Zhou XE; Center for Cancer and Cell Biology, Program for Structural Biology, Van Andel Institute, Grand Rapids, MI 49503, USA.
Chen M; Department of Pharmaceutical Sciences, Computational Chemical Genomics Screen Center, School of Pharmacy, and NIDA National Center of Excellence for Computational Drug Abuse Research, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Wang L; Laboratory for GPCR Biology, Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Meng X; David Van Andel Advanced Cryo-Electron Microscopy Suite, Van Andel Research Institute, Grand Rapids, MI 49503, USA.
Xue Y; Department of Pharmaceutical Sciences, Computational Chemical Genomics Screen Center, School of Pharmacy, and NIDA National Center of Excellence for Computational Drug Abuse Research, University of Pittsburgh, Pittsburgh, PA 15261, USA; Department of Pharmacy and Therapeutics, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Wang J; Department of Pharmaceutical Sciences, Computational Chemical Genomics Screen Center, School of Pharmacy, and NIDA National Center of Excellence for Computational Drug Abuse Research, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Liu H; Laboratory for GPCR Biology, Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.
McGuire TF; Department of Pharmaceutical Sciences, Computational Chemical Genomics Screen Center, School of Pharmacy, and NIDA National Center of Excellence for Computational Drug Abuse Research, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Zhao G; David Van Andel Advanced Cryo-Electron Microscopy Suite, Van Andel Research Institute, Grand Rapids, MI 49503, USA.
Melcher K; Center for Cancer and Cell Biology, Program for Structural Biology, Van Andel Institute, Grand Rapids, MI 49503, USA.
Zhang C; Laboratory for GPCR Biology, Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA. Electronic address: .
Xu HE; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. Electronic address: .
Xie XQ; Department of Pharmaceutical Sciences, Computational Chemical Genomics Screen Center, School of Pharmacy, and NIDA National Center of Excellence for Computational Drug Abuse Research, University of Pittsburgh, Pittsburgh, PA 15261, USA; Drug Discovery Institute and Departments of Computational Biology and of Structural Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA. Electronic address: .; Pokaż więcej
Źródło :: Cell [Cell] 2020 Feb 20; Vol. 180 (4), pp. 645-654.e13. Date of Electronic Publication: 2020 Jan 30.
Typ publikacji :: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :: Signal Transduction*
GTP-Binding Protein alpha Subunits, Gi-Go/*chemistry
Receptor, Cannabinoid, CB2/*chemistry
Animals ; Binding Sites ; CHO Cells ; Cannabinoid Receptor Agonists/chemical synthesis ; Cannabinoid Receptor Agonists/pharmacology ; Cannabinoid Receptor Antagonists/chemical synthesis ; Cannabinoid Receptor Antagonists/pharmacology ; Cricetinae ; Cricetulus ; Cryoelectron Microscopy ; GTP-Binding Protein alpha Subunits, Gi-Go/metabolism ; Humans ; Molecular Docking Simulation ; Protein Binding ; Receptor, Cannabinoid, CB2/agonists ; Receptor, Cannabinoid, CB2/antagonists & inhibitors ; Receptor, Cannabinoid, CB2/metabolism ; Sf9 Cells ; Spodoptera
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 12 12.

Tytuł :: Organized cannabinoid receptor distribution in neurons revealed by super-resolution fluorescence imaging.
Autorzy :: Li H; iHuman Institute, ShanghaiTech University, 201210, Shanghai, China.
Yang J; iHuman Institute, ShanghaiTech University, 201210, Shanghai, China.; University of the Chinese Academy of Sciences, 100049, Beijing, China.; School of Life Science and Technology, ShanghaiTech University, 201210, Shanghai, China.
Tian C; iHuman Institute, ShanghaiTech University, 201210, Shanghai, China.
Diao M; iHuman Institute, ShanghaiTech University, 201210, Shanghai, China.
Wang Q; iHuman Institute, ShanghaiTech University, 201210, Shanghai, China.; University of the Chinese Academy of Sciences, 100049, Beijing, China.; School of Life Science and Technology, ShanghaiTech University, 201210, Shanghai, China.
Zhao S; iHuman Institute, ShanghaiTech University, 201210, Shanghai, China.
Li S; iHuman Institute, ShanghaiTech University, 201210, Shanghai, China.
Tan F; iHuman Institute, ShanghaiTech University, 201210, Shanghai, China.
Hua T; iHuman Institute, ShanghaiTech University, 201210, Shanghai, China.
Qin Y; School of Life Science and Technology, ShanghaiTech University, 201210, Shanghai, China.
Lin CP; School of Life Science and Technology, ShanghaiTech University, 201210, Shanghai, China.
Deska-Gauthier D; Department of Medical Neuroscience, Dalhousie University, Halifax, NS, B3H 4R2, Canada.
Thompson GJ; iHuman Institute, ShanghaiTech University, 201210, Shanghai, China.
Zhang Y; Department of Medical Neuroscience, Dalhousie University, Halifax, NS, B3H 4R2, Canada.
Shui W; iHuman Institute, ShanghaiTech University, 201210, Shanghai, China.; School of Life Science and Technology, ShanghaiTech University, 201210, Shanghai, China.
Liu ZJ; iHuman Institute, ShanghaiTech University, 201210, Shanghai, China.; School of Life Science and Technology, ShanghaiTech University, 201210, Shanghai, China.
Wang T; School of Life Science and Technology, ShanghaiTech University, 201210, Shanghai, China.
Zhong G; iHuman Institute, ShanghaiTech University, 201210, Shanghai, China. .; School of Life Science and Technology, ShanghaiTech University, 201210, Shanghai, China. .; Pokaż więcej
Źródło :: Nature communications [Nat Commun] 2020 Nov 11; Vol. 11 (1), pp. 5699. Date of Electronic Publication: 2020 Nov 11.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Brain/*cytology
Molecular Imaging/*methods
Neurons/*metabolism
Receptor, Cannabinoid, CB1/*metabolism
Animals ; Axons/metabolism ; Brain/metabolism ; Cells, Cultured ; Cytoskeleton/metabolism ; Female ; Fluorescence Recovery After Photobleaching ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Microscopy, Fluorescence/methods ; Rats, Sprague-Dawley ; Receptor, Cannabinoid, CB1/analysis ; Receptor, Cannabinoid, CB1/genetics
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 13 13.

Tytuł :: A Novel Alternative in the Treatment of Detrusor Overactivity? In Vivo Activity of O-1602, the Newly Synthesized Agonist of GPR55 and GPR18 Cannabinoid Receptors.
Autorzy :: Wróbel A; Second Department of Gynecology, Medical University of Lublin, 8 Jaczewskiego St., PL-20954 Lublin, Poland.
Szopa A; Chair and Department of Applied and Social Pharmacy, Laboratory of Preclinical Testing, Medical University of Lublin, 1 Chodźki St., PL-20093 Lublin, Poland.
Serefko A; Chair and Department of Applied and Social Pharmacy, Laboratory of Preclinical Testing, Medical University of Lublin, 1 Chodźki St., PL-20093 Lublin, Poland.
Poleszak E; Chair and Department of Applied and Social Pharmacy, Laboratory of Preclinical Testing, Medical University of Lublin, 1 Chodźki St., PL-20093 Lublin, Poland.; Pokaż więcej
Źródło :: Molecules (Basel, Switzerland) [Molecules] 2020 Mar 18; Vol. 25 (6). Date of Electronic Publication: 2020 Mar 18.
Typ publikacji :: Journal Article
MeSH Terms :: Cannabinoid Receptor Agonists*/chemical synthesis
Cannabinoid Receptor Agonists*/chemistry
Cannabinoid Receptor Agonists*/pharmacology
Receptors, G-Protein-Coupled*/agonists
Receptors, G-Protein-Coupled*/metabolism
Cannabidiol/*analogs & derivatives
Receptors, Cannabinoid/*metabolism
Urinary Bladder, Overactive/*drug therapy
Animals ; Cannabidiol/chemical synthesis ; Cannabidiol/chemistry ; Cannabidiol/pharmacology ; Female ; Rats ; Rats, Wistar ; Urinary Bladder, Overactive/metabolism ; Urinary Bladder, Overactive/physiopathology
: Czasopismo naukowe

Szczegóły Pełny tekst

Skocz do pozycji: 14 14.

Tytuł :: Cannabinoid receptor expression in non-small cell lung cancer. Effectiveness of tetrahydrocannabinol and cannabidiol inhibiting cell proliferation and epithelial-mesenchymal transition in vitro.
Autorzy :: Milian L; Department of Pathology, Faculty of Medicine and Odontology, University of Valencia, Valencia, Spain.; Research Institute of the University Clinical Hospital of Valencia (INCLIVA), Valencia, Spain.
Mata M; Department of Pathology, Faculty of Medicine and Odontology, University of Valencia, Valencia, Spain.; Research Institute of the University Clinical Hospital of Valencia (INCLIVA), Valencia, Spain.; Networking Research Center on Respiratory Diseases (CIBERER), ISCIII, Carretera Soller Bunyola, Mallorca, Illes Balears, Spain.
Alcacer J; Patologika S.L. Legión Española Square, Valencia, Spain.
Oliver M; Department of Pathology, Faculty of Medicine and Odontology, University of Valencia, Valencia, Spain.
Sancho-Tello M; Department of Pathology, Faculty of Medicine and Odontology, University of Valencia, Valencia, Spain.; Research Institute of the University Clinical Hospital of Valencia (INCLIVA), Valencia, Spain.
Martín de Llano JJ; Department of Pathology, Faculty of Medicine and Odontology, University of Valencia, Valencia, Spain.; Research Institute of the University Clinical Hospital of Valencia (INCLIVA), Valencia, Spain.
Camps C; University General Hospital of Valencia, Valencia, Spain.
Galbis J; Alzira Hospital, Carretera de Corbera, Alzira, Valencia, Spain.
Carretero J; Department of Physiology, Faculty of Medicine and Odontology, University of Valencia, Valencia, Spain.
Carda C; Department of Pathology, Faculty of Medicine and Odontology, University of Valencia, Valencia, Spain.; Research Institute of the University Clinical Hospital of Valencia (INCLIVA), Valencia, Spain.; Pokaż więcej
Źródło :: PloS one [PLoS One] 2020 Feb 12; Vol. 15 (2), pp. e0228909. Date of Electronic Publication: 2020 Feb 12 (Print Publication: 2020).
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Cannabidiol/*metabolism
Carcinoma, Non-Small-Cell Lung/*metabolism
Cell Proliferation/*physiology
Dronabinol/*metabolism
Epithelial-Mesenchymal Transition/*physiology
Lung Neoplasms/*metabolism
Receptor, Cannabinoid, CB1/*metabolism
Receptor, Cannabinoid, CB2/*metabolism
A549 Cells ; Adult ; Aged ; Aged, 80 and over ; Cannabinoid Receptor Agonists/pharmacology ; Cannabinoids/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Epithelial-Mesenchymal Transition/drug effects ; Female ; Gene Expression/drug effects ; Humans ; Male ; Middle Aged ; Psychotropic Drugs/pharmacology
: Czasopismo naukowe

Szczegóły Pełny tekst Pełny tekst

Skocz do pozycji: 15 15.

Tytuł :: The role of cannabinoid 1 receptor in the nucleus accumbens on tramadol induced conditioning and reinstatement.
Autorzy :: Sadeghi-Adl M; Pharmaceutical Sciences Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Sadat-Shirazi MS; Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran.
Shahini F; Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran.
Akbarabadi A; Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran.
Khalifeh S; Cognitive and Neuroscience Research Center (CNRC), Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Borzabadi S; Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Nasehi M; Cognitive and Neuroscience Research Center (CNRC), Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
Zarrindast MR; Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran; Cognitive and Neuroscience Research Center (CNRC), Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Endocrinology and Metabolism Research Institute, Tehran University of Medical Science, Tehran, Iran.. Electronic address: .; Pokaż więcej
Źródło :: Life sciences [Life Sci] 2020 Nov 01; Vol. 260, pp. 118430. Date of Electronic Publication: 2020 Sep 13.
Typ publikacji :: Journal Article
MeSH Terms :: Analgesics, Opioid/*adverse effects
Conditioning, Psychological/*drug effects
Nucleus Accumbens/*drug effects
Receptor, Cannabinoid, CB1/*physiology
Tramadol/*adverse effects
Analgesics, Opioid/administration & dosage ; Animals ; Conditioning, Classical ; Dose-Response Relationship, Drug ; Extinction, Psychological/drug effects ; Male ; Nucleus Accumbens/metabolism ; Piperidines/administration & dosage ; Piperidines/pharmacology ; Pyrazoles/administration & dosage ; Pyrazoles/pharmacology ; Rats, Wistar ; Receptor, Cannabinoid, CB1/agonists ; Tramadol/administration & dosage
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 16 16.

Tytuł :: Histone methyltransferase G9a diminishes expression of cannabinoid CB 1 receptors in primary sensory neurons in neuropathic pain.
Autorzy :: Luo Y; Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas 77030.; Department of Laboratory Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China.
Zhang J; Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas 77030.
Chen L; Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas 77030.; School of Physical Education, Jianghan University, Wuhan, Hubei 430056, China.
Chen SR; Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas 77030.
Chen H; Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas 77030.
Zhang G; Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas 77030.
Pan HL; Center for Neuroscience and Pain Research, Department of Anesthesiology and Perioperative Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas 77030 .; Pokaż więcej
Źródło :: The Journal of biological chemistry [J Biol Chem] 2020 Mar 13; Vol. 295 (11), pp. 3553-3562. Date of Electronic Publication: 2020 Feb 04.
Typ publikacji :: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :: Histone-Lysine N-Methyltransferase/*metabolism
Neuralgia/*metabolism
Receptor, Cannabinoid, CB1/*metabolism
Sensory Receptor Cells/*metabolism
Analgesics/pharmacology ; Analgesics/therapeutic use ; Animals ; Cells, Cultured ; Ganglia, Spinal/drug effects ; Ganglia, Spinal/metabolism ; Gene Deletion ; Gene Silencing ; Glutamates/metabolism ; Histone-Lysine N-Methyltransferase/antagonists & inhibitors ; Histones/metabolism ; Lysine/metabolism ; Male ; Methylation ; Mice, Inbred C57BL ; Nerve Tissue/injuries ; Nerve Tissue/pathology ; Neuralgia/drug therapy ; Neuralgia/pathology ; Promoter Regions, Genetic/genetics ; Rats, Sprague-Dawley ; Receptor, Cannabinoid, CB1/agonists ; Receptor, Cannabinoid, CB1/genetics ; Receptor, Cannabinoid, CB2/metabolism ; Spinal Cord/pathology
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 17 17.

Tytuł :: The GPR55 antagonist CID16020046 protects against ox-LDL-induced inflammation in human aortic endothelial cells (HAECs).
Autorzy :: Wang Y; Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Cardiac Arrhythmias Therapeutic Service Center, Chongqing, 400010, China.
Pan W; Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Cardiac Arrhythmias Therapeutic Service Center, Chongqing, 400010, China; Department of Endocrinology, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China.
Wang Y; Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, 563006, China. Electronic address: .
Yin Y; Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing Cardiac Arrhythmias Therapeutic Service Center, Chongqing, 400010, China. Electronic address: .; Pokaż więcej
Źródło :: Archives of biochemistry and biophysics [Arch Biochem Biophys] 2020 Mar 15; Vol. 681, pp. 108254. Date of Electronic Publication: 2020 Jan 03.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Azabicyclo Compounds/*pharmacology
Benzoates/*pharmacology
Cannabinoid Receptor Antagonists/*pharmacology
Inflammation/*prevention & control
Lipoproteins, LDL/*metabolism
Oxidative Stress/*drug effects
Cell Line ; Humans ; Inflammation/metabolism ; Receptors, Cannabinoid/metabolism
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 18 18.

Tytuł :: The therapeutic role of cannabinoid receptors and its agonists or antagonists in Parkinson's disease.
Autorzy :: Han QW; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica& Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Yuan YH; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica& Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. Electronic address: .
Chen NH; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica& Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. Electronic address: .; Pokaż więcej
Źródło :: Progress in neuro-psychopharmacology & biological psychiatry [Prog Neuropsychopharmacol Biol Psychiatry] 2020 Jan 10; Vol. 96, pp. 109745. Date of Electronic Publication: 2019 Aug 20.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :: Cannabinoid Receptor Agonists/*metabolism
Cannabinoid Receptor Antagonists/*metabolism
Parkinson Disease/*drug therapy
Parkinson Disease/*metabolism
Receptor, Cannabinoid, CB1/*metabolism
Receptor, Cannabinoid, CB2/*metabolism
Animals ; Arachidonic Acids/metabolism ; Arachidonic Acids/therapeutic use ; Cannabinoid Receptor Agonists/therapeutic use ; Cannabinoid Receptor Antagonists/therapeutic use ; Cannabinoid Receptor Modulators/metabolism ; Cannabinoid Receptor Modulators/therapeutic use ; Cannabinoids/metabolism ; Cannabinoids/therapeutic use ; Capsaicin/analogs & derivatives ; Capsaicin/metabolism ; Capsaicin/therapeutic use ; Endocannabinoids/metabolism ; Endocannabinoids/therapeutic use ; Humans ; Receptor, Cannabinoid, CB1/agonists ; Receptor, Cannabinoid, CB1/antagonists & inhibitors ; Receptor, Cannabinoid, CB2/agonists ; Receptor, Cannabinoid, CB2/antagonists & inhibitors
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 19 19.

Tytuł :: Cannabinoid receptor 2 activation decreases severity of cyclophosphamide-induced cystitis via regulating autophagy.
Autorzy :: Liu Q; Department of Urology, Qilu Hospital of Shandong University, Jinan, China.
Wu Z; Department of Urology, Qilu Hospital of Shandong University, Jinan, China.
Liu Y; Department of Urology, Qilu Hospital of Shandong University, Jinan, China.
Chen L; Department of Urology, Qilu Hospital of Shandong University, Jinan, China.
Zhao H; Department of Urology, Qilu Hospital of Shandong University, Jinan, China.
Guo H; Department of Urology, Qilu Hospital of Shandong University, Jinan, China.
Zhu K; Department of Urology, Qilu Hospital of Shandong University, Jinan, China.
Wang W; Department of Urology, Qilu Hospital of Shandong University, Jinan, China.
Chen S; Department of Urology, Qilu Hospital of Shandong University, Jinan, China.
Zhou N; Department of Urology, Qilu Hospital of Shandong University, Jinan, China.
Li Y; Department of Urology, Qilu Hospital of Shandong University, Jinan, China.
Shi B; Department of Urology, Qilu Hospital of Shandong University, Jinan, China.; Pokaż więcej
Źródło :: Neurourology and urodynamics [Neurourol Urodyn] 2020 Jan; Vol. 39 (1), pp. 158-169. Date of Electronic Publication: 2019 Nov 14.
Typ publikacji :: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :: Autophagy/*drug effects
Cystitis/*metabolism
Receptor, Cannabinoid, CB2/*agonists
Animals ; Cannabinoid Receptor Agonists/pharmacology ; Cannabinoid Receptor Antagonists/pharmacology ; Cannabinoids/pharmacology ; Cyclophosphamide ; Cystitis/chemically induced ; Female ; Indoles/pharmacology ; Mice ; Mice, Inbred C57BL ; Oxidative Stress/drug effects ; Receptor, Cannabinoid, CB2/antagonists & inhibitors ; Urination/drug effects
: Czasopismo naukowe

Szczegóły

Skocz do pozycji: 20 20.

Tytuł :: Cannabinoid system involves in the analgesic effect of protocatechuic acid.
Autorzy :: Dikmen DY; Institute of Health Sciences, Department of Pharmacology, Anadolu University, 26470, Eskisehir, Turkey.
Okcay Y; Institute of Health Sciences, Department of Pharmacology, Anadolu University, 26470, Eskisehir, Turkey.
Arslan R; Faculty of Pharmacy, Department of Pharmacology, Anadolu University, 26470, Eskisehir, Turkey.
Bektas N; Faculty of Pharmacy, Department of Pharmacology, Anadolu University, 26470, Eskisehir, Turkey. .; Pokaż więcej
Źródło :: Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences [Daru] 2019 Dec; Vol. 27 (2), pp. 605-612. Date of Electronic Publication: 2019 Jul 19.
Typ publikacji :: Journal Article
MeSH Terms :: Acetic Acid/*adverse effects
Analgesics/*administration & dosage
Hydroxybenzoates/*administration & dosage
Pain/*drug therapy
Receptors, Cannabinoid/*metabolism
Analgesics/pharmacology ; Animals ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Hydroxybenzoates/pharmacology ; Indoles/administration & dosage ; Indoles/pharmacology ; Male ; Mice ; Pain/chemically induced ; Pain/metabolism ; Piperidines/administration & dosage ; Piperidines/pharmacology ; Pyrazoles/administration & dosage ; Pyrazoles/pharmacology ; Receptor, Cannabinoid, CB1/antagonists & inhibitors ; Receptor, Cannabinoid, CB1/metabolism ; Receptor, Cannabinoid, CB2/antagonists & inhibitors ; Receptor, Cannabinoid, CB2/metabolism
: Czasopismo naukowe

Szczegóły Pełny tekst

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