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Tytuł:
Beta-Caryophyllene, a Cannabinoid Receptor Type 2 Selective Agonist, in Emotional and Cognitive Disorders.
Autorzy:
Ricardi C; Department of Pathology, University of Pisa, 56126 Pisa, Italy.
Barachini S; Hematology Division, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
Consoli G; Department of Psychiatry, University of Pisa, 56126 Pisa, Italy.
Marazziti D; Department of Psychiatry, University of Pisa, 56126 Pisa, Italy.; UniCamillus, Saint Camillus International University of Health and Medical Sciences, 00151 Rome, Italy.
Polini B; Department of Pathology, University of Pisa, 56126 Pisa, Italy.
Chiellini G; Department of Pathology, University of Pisa, 56126 Pisa, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Mar 11; Vol. 25 (6). Date of Electronic Publication: 2024 Mar 11.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Cannabinoid Receptor Agonists*/pharmacology
Cannabinoid Receptor Agonists*/therapeutic use
Cognitive Dysfunction*
Polycyclic Sesquiterpenes*
Humans ; Adolescent ; Pandemics ; Post-Acute COVID-19 Syndrome ; Receptors, Cannabinoid ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Receptor, Cannabinoid, CB2
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
CB2 Cannabinoid Receptor as a Potential Target in Myocardial Infarction: Exploration of Molecular Pathogenesis and Therapeutic Strategies.
Autorzy:
More SA; Department of Pharmacology, Shri Vile Parle Kelavani Mandal's Institute of Pharmacy, Dhule 424001, Maharashtra, India.
Deore RS; Department of Pharmacology, Shri Vile Parle Kelavani Mandal's Institute of Pharmacy, Dhule 424001, Maharashtra, India.
Pawar HD; Department of Pharmacology, Shri Vile Parle Kelavani Mandal's Institute of Pharmacy, Dhule 424001, Maharashtra, India.
Sharma C; Department of Internal Medicine, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates.
Nakhate KT; Department of Pharmacology, Shri Vile Parle Kelavani Mandal's Institute of Pharmacy, Dhule 424001, Maharashtra, India.
Rathod SS; Department of Pharmacology, Shri Vile Parle Kelavani Mandal's Institute of Pharmacy, Dhule 424001, Maharashtra, India.
Ojha S; Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates.
Goyal SN; Department of Pharmacology, Shri Vile Parle Kelavani Mandal's Institute of Pharmacy, Dhule 424001, Maharashtra, India.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Jan 30; Vol. 25 (3). Date of Electronic Publication: 2024 Jan 30.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Cannabinoids*/pharmacology
Cannabinoids*/therapeutic use
Cannabinoids*/metabolism
Myocardial Infarction*/drug therapy
Myocardial Infarction*/genetics
Myocardial Infarction*/metabolism
Receptor, Cannabinoid, CB1*/genetics
Receptor, Cannabinoid, CB1*/metabolism
Humans ; Endocannabinoids/metabolism ; Myocardium/metabolism ; Receptor, Cannabinoid, CB2/genetics ; Receptor, Cannabinoid, CB2/metabolism ; Receptors, Cannabinoid/metabolism ; Dronabinol/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Evaluating signaling bias for synthetic cannabinoid receptor agonists at the cannabinoid CB 2 receptor.
Autorzy:
Patel M; Department of Pharmacology and Toxicology, University of Otago, Dunedin, New Zealand.
Grimsey NL; Department of Pharmacology and Clinical Pharmacology, School of Medical Sciences, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Banister SD; Lambert Initiative for Cannabinoid Therapeutics, Brain and Mind Centre, University of Sydney, New South Wales, Australia.; School of Chemistry, Faculty of Science, University of Sydney, New South Wales, Australia.
Finlay DB; Department of Pharmacology and Toxicology, University of Otago, Dunedin, New Zealand.
Glass M; Department of Pharmacology and Toxicology, University of Otago, Dunedin, New Zealand.
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Źródło:
Pharmacology research & perspectives [Pharmacol Res Perspect] 2023 Dec; Vol. 11 (6), pp. e01157.
Typ publikacji:
Journal Article
MeSH Terms:
Cannabinoid Receptor Agonists*/pharmacology
Cannabinoid Receptor Agonists*/chemistry
Cannabinoids*/pharmacology
Humans ; Receptors, Cannabinoid ; Ligands ; HEK293 Cells
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Role of the CB2 Cannabinoid Receptor in the Regulation of Food Intake: A Systematic Review.
Autorzy:
Rodríguez-Serrano LM; Facultad de Psicología, Universidad Anáhuac México, Universidad Anáhuac Avenue #46, Lomas Anáhuac, Huixquilucan 52786, Mexico.
Chávez-Hernández ME; Facultad de Psicología, Universidad Anáhuac México, Universidad Anáhuac Avenue #46, Lomas Anáhuac, Huixquilucan 52786, Mexico.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Dec 15; Vol. 24 (24). Date of Electronic Publication: 2023 Dec 15.
Typ publikacji:
Systematic Review; Journal Article; Review
MeSH Terms:
Cannabinoids*/metabolism
Cannabinoids*/pharmacology
Receptor, Cannabinoid, CB2*/drug effects
Receptor, Cannabinoid, CB2*/metabolism
Animals ; Mice ; Brain ; Diet ; Eating ; Receptor, Cannabinoid, CB1
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Interaction of Synthetic Cannabinoid Receptor Agonists with Cannabinoid Receptor I: Insights into Activation Molecular Mechanism.
Autorzy:
Gavryushov S; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilova Str. 32, Moscow 119991, Russia.; Institute for Translational Medicine and Biotechnology, Sechenov First Moscow State Medical University, 2-4 Bolshaya Pirogovskaya Str., Moscow 119991, Russia.
Bashilov A; Institute for Translational Medicine and Biotechnology, Sechenov First Moscow State Medical University, 2-4 Bolshaya Pirogovskaya Str., Moscow 119991, Russia.; Skolkovo Institute of Science and Technology, Bolshoy Boulevard 30, Bld. 1, Moscow 121205, Russia.
Cherashev-Tumanov KV; Institute for Translational Medicine and Biotechnology, Sechenov First Moscow State Medical University, 2-4 Bolshaya Pirogovskaya Str., Moscow 119991, Russia.
Kuzmich NN; The Maurice and Vivienne Wohl Institute for Drug Discovery, Weizmann Institute of Science, Rehovot 7610001, Israel.
Burykina TI; Institute for Translational Medicine and Biotechnology, Sechenov First Moscow State Medical University, 2-4 Bolshaya Pirogovskaya Str., Moscow 119991, Russia.
Izotov BN; Institute for Translational Medicine and Biotechnology, Sechenov First Moscow State Medical University, 2-4 Bolshaya Pirogovskaya Str., Moscow 119991, Russia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Oct 03; Vol. 24 (19). Date of Electronic Publication: 2023 Oct 03.
Typ publikacji:
Journal Article
MeSH Terms:
Cannabinoid Receptor Agonists*/pharmacology
Cannabinoid Receptor Agonists*/chemistry
Molecular Dynamics Simulation*
Ligands ; Receptors, Cannabinoid ; Receptor, Cannabinoid, CB1
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Systematic Modification of the Substitution Pattern of the 7-Hydroxy-5-oxopyrazolo[4,3- b ]pyridine-6-carboxamide Scaffold Enabled the Discovery of New Ligands with High Affinity and Selectivity for the Cannabinoid Type 2 Receptor.
Autorzy:
Mugnaini C; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy.
Kostrzewa M; National Research Council of Italy, Institute of Biomolecular Chemistry, 80078 Pozzuoli, Italy.
Casini M; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy.
Kumar P; National Research Council of Italy, Institute of Biomolecular Chemistry, 80078 Pozzuoli, Italy.
Catallo V; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy.
Allarà M; National Research Council of Italy, Institute of Biomolecular Chemistry, 80078 Pozzuoli, Italy.
Guastaferro L; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy.
Brizzi A; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy.
Paolino M; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy.
Tafi A; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy.
Kapatais C; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy.
Giorgi G; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy.
Vacondio F; Department of Food and Drug, University of Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy.
Mor M; Department of Food and Drug, University of Parma, Parco Area delle Scienze 27/A, 43124 Parma, Italy.
Corelli F; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena, Italy.
Ligresti A; National Research Council of Italy, Institute of Biomolecular Chemistry, 80078 Pozzuoli, Italy.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Jun 24; Vol. 28 (13). Date of Electronic Publication: 2023 Jun 24.
Typ publikacji:
Journal Article
MeSH Terms:
Receptor, Cannabinoid, CB2*
Cannabinoids*
Ligands ; Drug Inverse Agonism ; Structure-Activity Relationship ; Pyridines ; Receptor, Cannabinoid, CB1
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Structure-Based Virtual Screening and Molecular Dynamics Simulation Assessments of Depsidones as Possible Selective Cannabinoid Receptor Type 2 Agonists.
Autorzy:
Mohamed GA; Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Omar AM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.; Center for Artificial Intelligence in Precision Medicines, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
AlKharboush DF; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Fallatah MA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.; King Abdulaziz Medical City, Jeddah 21423, Saudi Arabia.
Sindi IA; Department of Biology, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
El-Agamy DS; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
Ibrahim SRM; Department of Chemistry, Preparatory Year Program, Batterjee Medical College, Jeddah 21442, Saudi Arabia.; Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Feb 13; Vol. 28 (4). Date of Electronic Publication: 2023 Feb 13.
Typ publikacji:
Journal Article
MeSH Terms:
Cannabinoid Receptor Agonists*/chemistry
Molecular Dynamics Simulation*
Receptor, Cannabinoid, CB2 ; Acetylcholinesterase ; Ligands ; Receptor, Cannabinoid, CB1 ; Molecular Docking Simulation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Mechanisms of GPR55 Receptor Functional Selectivity during Apoptosis and Proliferation Regulation in Cancer Cells.
Autorzy:
Akimov MG; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, 117997 Moscow, Russia.
Gretskaya NM; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, 117997 Moscow, Russia.
Dudina PV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, 117997 Moscow, Russia.
Sherstyanykh GD; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, 117997 Moscow, Russia.
Zinchenko GN; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, 117997 Moscow, Russia.
Serova OV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, 117997 Moscow, Russia.
Degtyaryova KO; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, 117997 Moscow, Russia.
Deyev IE; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, 117997 Moscow, Russia.
Bezuglov VV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Miklukho-Maklaya 16/10, 117997 Moscow, Russia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Mar 14; Vol. 24 (6). Date of Electronic Publication: 2023 Mar 14.
Typ publikacji:
Journal Article
MeSH Terms:
Receptor, Cannabinoid, CB2*/genetics
Neoplasms*/genetics
Ligands ; Receptors, Cannabinoid/metabolism ; Signal Transduction ; Cell Proliferation ; Apoptosis ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism ; Receptor, Cannabinoid, CB1
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cannabinoid Receptor 1 Agonist ACEA and Cannabinoid Receptor 2 Agonist GW833972A Attenuates Cell-Mediated Immunity by Different Biological Mechanisms.
Autorzy:
Takheaw N; Division of Clinical Immunology, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.; Biomedical Technology Research Center, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
Jindaphun K; Division of Clinical Immunology, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.; Biomedical Technology Research Center, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
Pata S; Division of Clinical Immunology, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.; Biomedical Technology Research Center, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
Laopajon W; Division of Clinical Immunology, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.; Biomedical Technology Research Center, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
Kasinrerk W; Division of Clinical Immunology, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.; Biomedical Technology Research Center, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
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Źródło:
Cells [Cells] 2023 Mar 09; Vol. 12 (6). Date of Electronic Publication: 2023 Mar 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cannabinoid Receptor Agonists*/pharmacology
CD8-Positive T-Lymphocytes*
Immunity, Cellular ; Receptors, Cannabinoid
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Lysophosphatidylinositol Promotes Chemotaxis and Cytokine Synthesis in Mast Cells with Differential Participation of GPR55 and CB2 Receptors.
Autorzy:
Martínez-Aguilar LM; Departamento de Farmacobiología Centro de Investigación y de Estudios Avanzados (Cinvestav), Unidad Sede Sur. Calzada de los Tenorios No. 235, Col. Granjas Coapa, Tlalpan, Mexico City 14330, Mexico.
Ibarra-Sánchez A; Departamento de Farmacobiología Centro de Investigación y de Estudios Avanzados (Cinvestav), Unidad Sede Sur. Calzada de los Tenorios No. 235, Col. Granjas Coapa, Tlalpan, Mexico City 14330, Mexico.
Guerrero-Morán DJ; Departamento de Farmacobiología Centro de Investigación y de Estudios Avanzados (Cinvestav), Unidad Sede Sur. Calzada de los Tenorios No. 235, Col. Granjas Coapa, Tlalpan, Mexico City 14330, Mexico.
Macías-Silva M; Departamento de Biología Celular y Desarrollo, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Circuito Exterior S/N, Ciudad Universitaria, Mexico City 04510, Mexico.
Muñoz-Bello JO; Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología, Av. San Fernando No 22, Col. Sección XVI, Tlalpan, Mexico City 14080, Mexico.
Padilla A; Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Circuito Exterior S/N, Ciudad Universtiaria, Mexico City 04510, Mexico.
Lizano M; Unidad de Investigación Biomédica en Cáncer, Instituto Nacional de Cancerología, Av. San Fernando No 22, Col. Sección XVI, Tlalpan, Mexico City 14080, Mexico.; Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Circuito Exterior S/N, Ciudad Universitaria, Mexico City 04510, Mexico.
González-Espinosa C; Departamento de Farmacobiología Centro de Investigación y de Estudios Avanzados (Cinvestav), Unidad Sede Sur. Calzada de los Tenorios No. 235, Col. Granjas Coapa, Tlalpan, Mexico City 14330, Mexico.; Centro de Investigación sobre Envejecimiento (CIE), Cinvestav, Unidad Sede Sur. Calzada de los Tenorios No. 235 Col. Granjas Coapa, Tlalpan, Mexico City 14400, Mexico.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Mar 28; Vol. 24 (7). Date of Electronic Publication: 2023 Mar 28.
Typ publikacji:
Journal Article
MeSH Terms:
Receptors, G-Protein-Coupled*/genetics
Receptor, Cannabinoid, CB2*/genetics
Mice ; Humans ; Animals ; Chemotaxis ; Mast Cells ; Cytokines ; Actins ; Receptors, Cannabinoid/genetics ; Lysophospholipids/pharmacology ; Lysophospholipids/physiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
N -[1,3-Dialkyl(aryl)-2-oxoimidazolidin-4-ylidene]-aryl(alkyl)sulphonamides as Novel Selective Human Cannabinoid Type 2 Receptor (hCB2R) Ligands; Insights into the Mechanism of Receptor Activation/Deactivation.
Autorzy:
Gianquinto E; Department of Drug Science and Technology, University of Torino, 10125 Torino, Italy.
Sodano F; Department of Drug Science and Technology, University of Torino, 10125 Torino, Italy.; Department of Pharmacy, 'Federico II' University of Naples, 80131 Naples, Italy.
Rolando B; Department of Drug Science and Technology, University of Torino, 10125 Torino, Italy.
Kostrzewa M; National Research Council of Italy, Institute of Biomolecular Chemistry, 80078 Pozzuoli, Italy.
Allarà M; National Research Council of Italy, Institute of Biomolecular Chemistry, 80078 Pozzuoli, Italy.
Mahmoud AM; National Research Council of Italy, Institute of Biomolecular Chemistry, 80078 Pozzuoli, Italy.
Kumar P; National Research Council of Italy, Institute of Biomolecular Chemistry, 80078 Pozzuoli, Italy.
Spyrakis F; Department of Drug Science and Technology, University of Torino, 10125 Torino, Italy.
Ligresti A; National Research Council of Italy, Institute of Biomolecular Chemistry, 80078 Pozzuoli, Italy.
Chegaev K; Department of Drug Science and Technology, University of Torino, 10125 Torino, Italy.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Nov 23; Vol. 27 (23). Date of Electronic Publication: 2022 Nov 23.
Typ publikacji:
Journal Article
MeSH Terms:
Cannabinoid Receptor Agonists*/chemistry
Cannabinoids*
Humans ; Protein Binding ; Ligands ; Structure-Activity Relationship ; Sulfonamides ; Receptor, Cannabinoid, CB2 ; Receptor, Cannabinoid, CB1
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cannabinoid effects in the microvasculature - CB, or not CB? That is the question! A mini-review.
Autorzy:
Lehmann C; Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, Halifax, NS, Canada.; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada.; Department of Pharmacology, Dalhousie University, Halifax, NS, Canada.; Department of Physiology and Biophysics, Dalhousie University, Halifax, NS, Canada.; Department of Computer Science, Dalhousie University, Halifax, NS, Canada.
Zhou J; Department of Anesthesia, Pain Management and Perioperative Medicine, Dalhousie University, Halifax, NS, Canada.
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Źródło:
Clinical hemorheology and microcirculation [Clin Hemorheol Microcirc] 2023; Vol. 83 (3), pp. 287-292.
Typ publikacji:
Review; Journal Article
MeSH Terms:
Cannabinoids*/pharmacology
Microvessels*/drug effects
Receptors, Cannabinoid*
Microcirculation*/drug effects
Humans ; Receptor, Cannabinoid, CB2
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Discovery of a pyrano[2,3-b]pyridine derivative YX-2102 as a cannabinoid receptor 2 agonist for alleviating lung fibrosis.
Autorzy:
Liu T; College of Pharmacy, Third Military Medical University, Chongqing, 400038, China.
Gu J; College of Pharmacy, Third Military Medical University, Chongqing, 400038, China.
Yuan Y; College of Pharmacy, Third Military Medical University, Chongqing, 400038, China.
Yang Q; College of Pharmacy, Third Military Medical University, Chongqing, 400038, China.
Zheng PF; College of Pharmacy, Third Military Medical University, Chongqing, 400038, China.
Shan C; College of Pharmacy, Third Military Medical University, Chongqing, 400038, China.
Wang F; College of Pharmacy, Third Military Medical University, Chongqing, 400038, China.
Li H; College of Pharmacy, Third Military Medical University, Chongqing, 400038, China.
Xie XQ; Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Chen XH; College of Pharmacy, Third Military Medical University, Chongqing, 400038, China. .
Ouyang Q; College of Pharmacy, Third Military Medical University, Chongqing, 400038, China. .
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Źródło:
Journal of translational medicine [J Transl Med] 2022 Dec 06; Vol. 20 (1), pp. 565. Date of Electronic Publication: 2022 Dec 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cannabinoid Receptor Agonists*
Pulmonary Fibrosis*/drug therapy
Animals ; Rats ; Receptors, Cannabinoid
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Activation of cannabinoid-2 receptor protects against Pseudomonas aeruginosa induced acute lung injury and inflammation.
Autorzy:
Nagre N; Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA, 23507, USA. .
Nicholson G; Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA, 23507, USA.
Cong X; Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA, 23507, USA.
Lockett J; Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA, 23507, USA.
Pearson AC; Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA, 23507, USA.
Chan V; Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA, 23507, USA.
Kim WK; Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA, 23507, USA.
Vinod KY; Emotional Brain Institute, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, 10962, USA.; Department of Child and Adolescent Psychiatry, New York University Langone Health, New York, NY, USA.
Catravas JD; Frank Reidy Research Center for Bioelectrics, Old Dominion University, Norfolk, VA, 23508, USA.; School of Medical Diagnostic and Translational Sciences, College of Health Sciences, Old Dominion University, Norfolk, VA, 23508, USA.
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Źródło:
Respiratory research [Respir Res] 2022 Dec 03; Vol. 23 (1), pp. 326. Date of Electronic Publication: 2022 Dec 03.
Typ publikacji:
Journal Article
MeSH Terms:
Acute Lung Injury*/chemically induced
Acute Lung Injury*/genetics
Acute Lung Injury*/immunology
Acute Lung Injury*/prevention & control
Cannabinoids*/pharmacology
Cannabinoids*/therapeutic use
Inflammation*/genetics
Inflammation*/immunology
Inflammation*/prevention & control
Receptor, Cannabinoid, CB2*/genetics
Receptor, Cannabinoid, CB2*/immunology
Pseudomonas Infections*/genetics
Pseudomonas Infections*/immunology
Pseudomonas Infections*/microbiology
Pseudomonas Infections*/prevention & control
Animals ; Mice ; Cytokines ; Inflammasomes/genetics ; Inflammasomes/immunology ; Mice, Inbred C57BL ; NLR Family, Pyrin Domain-Containing 3 Protein ; Pseudomonas aeruginosa ; Receptors, Cannabinoid ; Respiratory Distress Syndrome ; Disease Models, Animal
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cannabinoid hyperemesis and pheochromocytoma hypertensive urgency: a case report.
Autorzy:
Arendash JM; Department of Anesthesiology, Stanford University, 300 Pasteur Dr., Stanford, CA, 94305, USA. .
Chiu C; Department of Anesthesiology, Stanford University, 300 Pasteur Dr., Stanford, CA, 94305, USA.
Wang J; Department of Anesthesiology, Stanford University, 300 Pasteur Dr., Stanford, CA, 94305, USA.
Mihm F; Department of Anesthesiology, Stanford University, 300 Pasteur Dr., Stanford, CA, 94305, USA.
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Źródło:
Journal of medical case reports [J Med Case Rep] 2024 Mar 19; Vol. 18 (1), pp. 161. Date of Electronic Publication: 2024 Mar 19.
Typ publikacji:
Case Reports; Journal Article
MeSH Terms:
Adrenal Gland Neoplasms*/complications
Adrenal Gland Neoplasms*/diagnostic imaging
Adrenal Gland Neoplasms*/surgery
Cannabinoid Hyperemesis Syndrome*
Cannabinoids*/adverse effects
Hypertensive Crisis*
Pheochromocytoma*/complications
Pheochromocytoma*/diagnostic imaging
Pheochromocytoma*/surgery
Aged ; Humans ; Male ; Catecholamines ; Vomiting/chemically induced
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Structure-Activity Relationship Development Efforts towards Peripherally Selective Analogs of the Cannabinoid Receptor Partial Agonist BAY 59-3074.
Autorzy:
Amato G; Center for Drug Discovery, RTI International, P.O. Box 12194, Research Triangle Park, NC 27709-2194, USA.
Vasukuttan V; Center for Drug Discovery, RTI International, P.O. Box 12194, Research Triangle Park, NC 27709-2194, USA.
Harris D; Center for Drug Discovery, RTI International, P.O. Box 12194, Research Triangle Park, NC 27709-2194, USA.
Laudermilk L; Center for Drug Discovery, RTI International, P.O. Box 12194, Research Triangle Park, NC 27709-2194, USA.
Lucitti J; Center for Drug Discovery, RTI International, P.O. Box 12194, Research Triangle Park, NC 27709-2194, USA.
Runyon S; Center for Drug Discovery, RTI International, P.O. Box 12194, Research Triangle Park, NC 27709-2194, USA.
Maitra R; Center for Drug Discovery, RTI International, P.O. Box 12194, Research Triangle Park, NC 27709-2194, USA.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Sep 02; Vol. 27 (17). Date of Electronic Publication: 2022 Sep 02.
Typ publikacji:
Journal Article
MeSH Terms:
Cannabinoid Receptor Agonists*/pharmacology
Pain*/drug therapy
Alkanesulfonates ; Animals ; Humans ; Nitriles ; Rats ; Receptor, Cannabinoid, CB1 ; Receptor, Cannabinoid, CB2 ; Receptors, Cannabinoid ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
GPR55 Inactivation Diminishes Splenic Responses and Improves Neurological Outcomes in the Mouse Ischemia/Reperfusion Stroke Model.
Autorzy:
Gajghate S; Department of Pathology and Laboratory Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Li H; Center for Substance Abuse Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
Rom S; Department of Pathology and Laboratory Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.; Center for Substance Abuse Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA 19140, USA.
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Źródło:
Cells [Cells] 2024 Feb 03; Vol. 13 (3). Date of Electronic Publication: 2024 Feb 03.
Typ publikacji:
Journal Article
MeSH Terms:
Ischemic Stroke*/complications
Receptors, Cannabinoid*
Animals ; Humans ; Mice ; Brain ; Disease Models, Animal ; Infarction, Middle Cerebral Artery/complications ; Plasminogen Activators ; Reperfusion ; Spleen
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Adolescent self-administration of the synthetic cannabinoid receptor agonist JWH-018 induces neurobiological and behavioral alterations in adult male mice.
Autorzy:
Margiani G; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Castelli MP; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Pintori N; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Frau R; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.; 'Guy Everett' Laboratory, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Ennas MG; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Pagano Zottola AC; INSERM, U1215 NeuroCentre Magendie, Bordeaux, France.; University of Bordeaux, Bordeaux, France.; Institut de Biochimie et Génétique Cellulaires, UMR 5095, Bordeaux, France.
Orrù V; Institute for Genetic and Biomedical Research, National Research Council (CNR), Lanusei, Italy.
Serra V; Institute for Genetic and Biomedical Research, National Research Council (CNR), Lanusei, Italy.
Fiorillo E; Institute for Genetic and Biomedical Research, National Research Council (CNR), Lanusei, Italy.
Fadda P; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.; Institute of Neuroscience-Cagliari, National Research Council (CNR), Cagliari, Italy.
Marsicano G; INSERM, U1215 NeuroCentre Magendie, Bordeaux, France.; University of Bordeaux, Bordeaux, France.
De Luca MA; Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy. .
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Źródło:
Psychopharmacology [Psychopharmacology (Berl)] 2022 Oct; Vol. 239 (10), pp. 3083-3102. Date of Electronic Publication: 2022 Aug 09.
Typ publikacji:
Journal Article
MeSH Terms:
Cannabinoid Receptor Agonists*/pharmacology
Chemokine CCL5*
Animals ; Calcium ; Calcium Carbonate ; Glial Fibrillary Acidic Protein ; Indoles ; Interleukin-13 ; Interleukin-2 ; Male ; Mice ; Naphthalenes ; Receptor, Cannabinoid, CB1
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Molecular basis for ligand modulation of the cannabinoid CB 1 receptor.
Autorzy:
Ramesh K; Department of Biophysics, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Rosenbaum DM; Department of Biophysics, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
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Źródło:
British journal of pharmacology [Br J Pharmacol] 2022 Jul; Vol. 179 (14), pp. 3487-3495. Date of Electronic Publication: 2021 Aug 12.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Cannabinoid Receptor Agonists*
Cannabinoids*
Endocannabinoids/metabolism ; Ligands ; Receptor, Cannabinoid, CB1 ; Receptor, Cannabinoid, CB2 ; Receptors, Cannabinoid/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Impact of the mouse estrus cycle on cannabinoid receptor agonist-induced molecular and behavioral outcomes.
Autorzy:
Kim HJJ; College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Zagzoog A; College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Black T; College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Baccetto SL; College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Ezeaka UC; College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Laprairie RB; College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.; Department of Pharmacology, College of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
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Źródło:
Pharmacology research & perspectives [Pharmacol Res Perspect] 2022 Jun; Vol. 10 (3), pp. e00950.
Typ publikacji:
Journal Article; Review; Research Support, Non-U.S. Gov't
MeSH Terms:
Cannabinoid Receptor Agonists*/pharmacology
Cannabinoids*/pharmacology
Animals ; Catalepsy/chemically induced ; Catalepsy/drug therapy ; Estrus ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Receptors, Cannabinoid
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 2850

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