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Wyszukujesz frazę ""Cannabinoid receptor"" wg kryterium: Temat


Tytuł :
Effects of combined 5-HT 2A and cannabinoid receptor modulation on a schizophrenia-related prepulse inhibition deficit in mice.
Autorzy :
Marques AM; Laboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Av. Carlos Chagas Filho, 373, bloco J, sala J1-029, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, CEP 21941-902, Brazil.; Graduate Program in Pharmacology and Medicinal Chemistry, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Macena MV; Laboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Av. Carlos Chagas Filho, 373, bloco J, sala J1-029, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, CEP 21941-902, Brazil.
Cardoso AR; Laboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Av. Carlos Chagas Filho, 373, bloco J, sala J1-029, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, CEP 21941-902, Brazil.
Hammes CSO; Laboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Av. Carlos Chagas Filho, 373, bloco J, sala J1-029, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, CEP 21941-902, Brazil.
Pinheiro FML; Laboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Av. Carlos Chagas Filho, 373, bloco J, sala J1-029, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, CEP 21941-902, Brazil.
Castro NG; Laboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Av. Carlos Chagas Filho, 373, bloco J, sala J1-029, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, CEP 21941-902, Brazil.; Graduate Program in Pharmacology and Medicinal Chemistry, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Neves GA; Laboratory of Molecular Pharmacology, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Av. Carlos Chagas Filho, 373, bloco J, sala J1-029, Cidade Universitária, Ilha do Fundão, Rio de Janeiro, RJ, CEP 21941-902, Brazil. .; Graduate Program in Pharmacology and Medicinal Chemistry, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil. .
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Źródło :
Psychopharmacology [Psychopharmacology (Berl)] 2020 Jun; Vol. 237 (6), pp. 1643-1655. Date of Electronic Publication: 2020 Feb 24.
Typ publikacji :
Journal Article
MeSH Terms :
Cannabinoid Receptor Antagonists/*administration & dosage
Prepulse Inhibition/*physiology
Receptor, Serotonin, 5-HT2A/*physiology
Receptors, Cannabinoid/*physiology
Schizophrenia/*drug therapy
Serotonin 5-HT2 Receptor Antagonists/*administration & dosage
8-Hydroxy-2-(di-n-propylamino)tetralin/administration & dosage ; Animals ; Benzoxazines/administration & dosage ; Cannabinoid Receptor Modulators/administration & dosage ; Cannabinoids/administration & dosage ; Dose-Response Relationship, Drug ; Drug Therapy, Combination ; Fluorobenzenes/administration & dosage ; Male ; Mice ; Morpholines/administration & dosage ; Naphthalenes/administration & dosage ; Piperidines/administration & dosage ; Prepulse Inhibition/drug effects ; Reflex, Startle/drug effects ; Reflex, Startle/physiology ; Serotonin 5-HT2 Receptor Agonists/administration & dosage ; Treatment Outcome
Czasopismo naukowe
Tytuł :
Mechanisms for the Risk of Acute Coronary Syndrome and Arrhythmia Associated With Phytogenic and Synthetic Cannabinoid Use.
Autorzy :
Richards JR; Department of Emergency Medicine, 70083University of California Davis Medical Center, Sacramento, California, CA, USA.
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Źródło :
Journal of cardiovascular pharmacology and therapeutics [J Cardiovasc Pharmacol Ther] 2020 Nov; Vol. 25 (6), pp. 508-522. Date of Electronic Publication: 2020 Jun 26.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Acute Coronary Syndrome/*chemically induced
Arrhythmias, Cardiac/*chemically induced
Cannabinoid Receptor Agonists/*adverse effects
Cannabinoids/*adverse effects
Cannabis/*adverse effects
Heart/*drug effects
Marijuana Abuse/*complications
Marijuana Smoking/*adverse effects
Acute Coronary Syndrome/physiopathology ; Animals ; Arrhythmias, Cardiac/physiopathology ; Cannabinoid Receptor Agonists/chemical synthesis ; Cannabinoid Receptor Agonists/isolation & purification ; Cannabinoids/chemical synthesis ; Cannabinoids/isolation & purification ; Cannabis/chemistry ; Cardiotoxicity ; Heart/physiopathology ; Heart Rate/drug effects ; Humans ; Receptors, Cannabinoid/drug effects ; Risk Assessment ; Risk Factors ; Signal Transduction
Czasopismo naukowe
Tytuł :
The therapeutic role of cannabinoid receptors and its agonists or antagonists in Parkinson's disease.
Autorzy :
Han QW; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica& Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Yuan YH; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica& Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. Electronic address: .
Chen NH; State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica& Neuroscience Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. Electronic address: .
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Źródło :
Progress in neuro-psychopharmacology & biological psychiatry [Prog Neuropsychopharmacol Biol Psychiatry] 2020 Jan 10; Vol. 96, pp. 109745. Date of Electronic Publication: 2019 Aug 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Cannabinoid Receptor Agonists/*metabolism
Cannabinoid Receptor Antagonists/*metabolism
Parkinson Disease/*drug therapy
Parkinson Disease/*metabolism
Receptor, Cannabinoid, CB1/*metabolism
Receptor, Cannabinoid, CB2/*metabolism
Animals ; Arachidonic Acids/metabolism ; Arachidonic Acids/therapeutic use ; Cannabinoid Receptor Agonists/therapeutic use ; Cannabinoid Receptor Antagonists/therapeutic use ; Cannabinoid Receptor Modulators/metabolism ; Cannabinoid Receptor Modulators/therapeutic use ; Cannabinoids/metabolism ; Cannabinoids/therapeutic use ; Capsaicin/analogs & derivatives ; Capsaicin/metabolism ; Capsaicin/therapeutic use ; Endocannabinoids/metabolism ; Endocannabinoids/therapeutic use ; Humans ; Receptor, Cannabinoid, CB1/agonists ; Receptor, Cannabinoid, CB1/antagonists & inhibitors ; Receptor, Cannabinoid, CB2/agonists ; Receptor, Cannabinoid, CB2/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
Cannabinoid Antagonist Drug Discrimination in Nonhuman Primates.
Autorzy :
Kangas BD; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts (B.D.K., J.B.); Behavioral Biology Program, McLean Hospital, Belmont, Massachusetts (B.D.K., A.S.Z., J.B.); and Center for Drug Discovery, Northeastern University, Boston, Massachusetts (K.V., S.O.A., S.J., S.P.N., A.M.) .
Zakarian AS; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts (B.D.K., J.B.); Behavioral Biology Program, McLean Hospital, Belmont, Massachusetts (B.D.K., A.S.Z., J.B.); and Center for Drug Discovery, Northeastern University, Boston, Massachusetts (K.V., S.O.A., S.J., S.P.N., A.M.).
Vemuri K; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts (B.D.K., J.B.); Behavioral Biology Program, McLean Hospital, Belmont, Massachusetts (B.D.K., A.S.Z., J.B.); and Center for Drug Discovery, Northeastern University, Boston, Massachusetts (K.V., S.O.A., S.J., S.P.N., A.M.).
Alapafuja SO; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts (B.D.K., J.B.); Behavioral Biology Program, McLean Hospital, Belmont, Massachusetts (B.D.K., A.S.Z., J.B.); and Center for Drug Discovery, Northeastern University, Boston, Massachusetts (K.V., S.O.A., S.J., S.P.N., A.M.).
Jiang S; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts (B.D.K., J.B.); Behavioral Biology Program, McLean Hospital, Belmont, Massachusetts (B.D.K., A.S.Z., J.B.); and Center for Drug Discovery, Northeastern University, Boston, Massachusetts (K.V., S.O.A., S.J., S.P.N., A.M.).
Nikas SP; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts (B.D.K., J.B.); Behavioral Biology Program, McLean Hospital, Belmont, Massachusetts (B.D.K., A.S.Z., J.B.); and Center for Drug Discovery, Northeastern University, Boston, Massachusetts (K.V., S.O.A., S.J., S.P.N., A.M.).
Makriyannis A; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts (B.D.K., J.B.); Behavioral Biology Program, McLean Hospital, Belmont, Massachusetts (B.D.K., A.S.Z., J.B.); and Center for Drug Discovery, Northeastern University, Boston, Massachusetts (K.V., S.O.A., S.J., S.P.N., A.M.).
Bergman J; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts (B.D.K., J.B.); Behavioral Biology Program, McLean Hospital, Belmont, Massachusetts (B.D.K., A.S.Z., J.B.); and Center for Drug Discovery, Northeastern University, Boston, Massachusetts (K.V., S.O.A., S.J., S.P.N., A.M.).
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Źródło :
The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2020 Jan; Vol. 372 (1), pp. 119-127. Date of Electronic Publication: 2019 Oct 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Discrimination, Psychological*
Disease Models, Animal*
Cannabinoid Receptor Antagonists/*therapeutic use
Substance Withdrawal Syndrome/*drug therapy
Animals ; Benzopyrans/administration & dosage ; Benzopyrans/adverse effects ; Benzopyrans/therapeutic use ; Cannabinoid Receptor Agonists/administration & dosage ; Cannabinoid Receptor Agonists/adverse effects ; Cannabinoid Receptor Agonists/therapeutic use ; Cannabinoid Receptor Antagonists/administration & dosage ; Cannabinoid Receptor Antagonists/adverse effects ; Drug Evaluation, Preclinical/methods ; Drug Substitution/methods ; Male ; Rimonabant/administration & dosage ; Rimonabant/adverse effects ; Rimonabant/therapeutic use ; Saimiri ; Substance Withdrawal Syndrome/psychology
Czasopismo naukowe
Tytuł :
Antiemetic Effects of Cannabinoid Agonists in Nonhuman Primates.
Autorzy :
Wooldridge LM; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts (J.B., B.D.K.); Behavioral Biology Program, McLean Hospital, Belmont, Massachusetts (L.M.W., J.B., B.D.K.); and Center for Drug Discovery, Northeastern University, Boston, Massachusetts (L.J., Y.L., S.P.N., A.M.).
Ji L; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts (J.B., B.D.K.); Behavioral Biology Program, McLean Hospital, Belmont, Massachusetts (L.M.W., J.B., B.D.K.); and Center for Drug Discovery, Northeastern University, Boston, Massachusetts (L.J., Y.L., S.P.N., A.M.).
Liu Y; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts (J.B., B.D.K.); Behavioral Biology Program, McLean Hospital, Belmont, Massachusetts (L.M.W., J.B., B.D.K.); and Center for Drug Discovery, Northeastern University, Boston, Massachusetts (L.J., Y.L., S.P.N., A.M.).
Nikas SP; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts (J.B., B.D.K.); Behavioral Biology Program, McLean Hospital, Belmont, Massachusetts (L.M.W., J.B., B.D.K.); and Center for Drug Discovery, Northeastern University, Boston, Massachusetts (L.J., Y.L., S.P.N., A.M.).
Makriyannis A; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts (J.B., B.D.K.); Behavioral Biology Program, McLean Hospital, Belmont, Massachusetts (L.M.W., J.B., B.D.K.); and Center for Drug Discovery, Northeastern University, Boston, Massachusetts (L.J., Y.L., S.P.N., A.M.).
Bergman J; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts (J.B., B.D.K.); Behavioral Biology Program, McLean Hospital, Belmont, Massachusetts (L.M.W., J.B., B.D.K.); and Center for Drug Discovery, Northeastern University, Boston, Massachusetts (L.J., Y.L., S.P.N., A.M.).
Kangas BD; Department of Psychiatry, Harvard Medical School, Boston, Massachusetts (J.B., B.D.K.); Behavioral Biology Program, McLean Hospital, Belmont, Massachusetts (L.M.W., J.B., B.D.K.); and Center for Drug Discovery, Northeastern University, Boston, Massachusetts (L.J., Y.L., S.P.N., A.M.) .
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Źródło :
The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2020 Sep; Vol. 374 (3), pp. 462-468. Date of Electronic Publication: 2020 Jun 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Antiemetics/*pharmacology
Cannabinoid Receptor Agonists/*pharmacology
Animals ; Antiemetics/therapeutic use ; Arachidonic Acids/pharmacology ; Arachidonic Acids/therapeutic use ; Cannabinoid Receptor Agonists/therapeutic use ; Dronabinol/pharmacology ; Dronabinol/therapeutic use ; Drug Interactions ; Male ; Receptor, Cannabinoid, CB1/agonists ; Saimiri ; Salivation/drug effects ; Vomiting/drug therapy
Czasopismo naukowe
Tytuł :
Signalling profiles of a structurally diverse panel of synthetic cannabinoid receptor agonists.
Autorzy :
Patel M; Department of Pharmacology and Toxicology, University of Otago, Dunedin, New Zealand; Department of Pharmacology and Clinical Pharmacology, University of Auckland, Auckland, New Zealand.
Manning JJ; Department of Pharmacology and Toxicology, University of Otago, Dunedin, New Zealand.
Finlay DB; Department of Pharmacology and Toxicology, University of Otago, Dunedin, New Zealand.
Javitch JA; Department of Psychiatry and Pharmacology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, United States; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY, United States.
Banister SD; Lambert Initiative for Cannabinoid Therapeutics, Brain and Mind Centre, University of Sydney, NSW, Australia; School of Chemistry, Faculty of Science, University of Sydney, NSW, Australia.
Grimsey NL; Department of Pharmacology and Clinical Pharmacology, University of Auckland, Auckland, New Zealand.
Glass M; Department of Pharmacology and Toxicology, University of Otago, Dunedin, New Zealand. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2020 May; Vol. 175, pp. 113871. Date of Electronic Publication: 2020 Feb 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cannabinoid Receptor Agonists/*pharmacology
Cannabinoids/*pharmacology
Designer Drugs/*pharmacology
Indoles/*pharmacology
Receptor, Cannabinoid, CB1/*metabolism
Receptor, Cannabinoid, CB2/*metabolism
Cannabinoid Receptor Agonists/chemistry ; Cannabinoid Receptor Agonists/metabolism ; Cannabinoids/chemistry ; Cannabinoids/metabolism ; Cyclic AMP ; Designer Drugs/chemistry ; Designer Drugs/metabolism ; Dose-Response Relationship, Drug ; HEK293 Cells ; Humans ; Indoles/chemistry ; Indoles/metabolism ; Ligands ; Protein Transport ; Receptor, Cannabinoid, CB1/genetics ; Receptor, Cannabinoid, CB2/genetics ; Signal Transduction ; Transfection ; beta-Arrestins/metabolism
Czasopismo naukowe
Tytuł :
Role of the endocannabinoid and endovanilloid systems in an animal model of schizophrenia-related emotional processing/cognitive deficit.
Autorzy :
Almeida V; Department of Pharmacology, Federal University of São Paulo (Universidade Federal de São Paulo - UNIFESP/EPM), São Paulo, Brazil.
Levin R; Department of Pharmacology, Federal University of São Paulo (Universidade Federal de São Paulo - UNIFESP/EPM), São Paulo, Brazil.
Peres FF; Department of Pharmacology, Federal University of São Paulo (Universidade Federal de São Paulo - UNIFESP/EPM), São Paulo, Brazil; National Institute for Translational Medicine (INCT-TM, CNPq), Ribeirão Preto, Brazil.
Suiama MA; Department of Pharmacology, Federal University of São Paulo (Universidade Federal de São Paulo - UNIFESP/EPM), São Paulo, Brazil.
Vendramini AM; Department of Pharmacology, Federal University of São Paulo (Universidade Federal de São Paulo - UNIFESP/EPM), São Paulo, Brazil.
Santos CM; Department of Pharmacology, Federal University of São Paulo (Universidade Federal de São Paulo - UNIFESP/EPM), São Paulo, Brazil.
Silva ND; Department of Pharmacology, Federal University of São Paulo (Universidade Federal de São Paulo - UNIFESP/EPM), São Paulo, Brazil.
Zuardi AW; National Institute for Translational Medicine (INCT-TM, CNPq), Ribeirão Preto, Brazil; Department of Neuroscience and Behavior, University of São Paulo, USP, Ribeirão Preto, Brazil.
Hallak JEC; National Institute for Translational Medicine (INCT-TM, CNPq), Ribeirão Preto, Brazil; Department of Neuroscience and Behavior, University of São Paulo, USP, Ribeirão Preto, Brazil.
Crippa JA; National Institute for Translational Medicine (INCT-TM, CNPq), Ribeirão Preto, Brazil; Department of Neuroscience and Behavior, University of São Paulo, USP, Ribeirão Preto, Brazil.
Abílio VC; Department of Pharmacology, Federal University of São Paulo (Universidade Federal de São Paulo - UNIFESP/EPM), São Paulo, Brazil; National Institute for Translational Medicine (INCT-TM, CNPq), Ribeirão Preto, Brazil. Electronic address: .
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Źródło :
Neuropharmacology [Neuropharmacology] 2019 Sep 01; Vol. 155, pp. 44-53. Date of Electronic Publication: 2019 May 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Disease Models, Animal*
Affective Symptoms/*metabolism
Cannabinoid Receptor Modulators/*metabolism
Cognitive Dysfunction/*metabolism
Endocannabinoids/*metabolism
Schizophrenia/*metabolism
Affective Symptoms/chemically induced ; Animals ; Arachidonic Acids/agonists ; Arachidonic Acids/antagonists & inhibitors ; Arachidonic Acids/metabolism ; Arachidonic Acids/pharmacology ; Arachidonic Acids/therapeutic use ; Cannabinoid Receptor Agonists/pharmacology ; Cannabinoid Receptor Agonists/therapeutic use ; Cognitive Dysfunction/chemically induced ; Endocannabinoids/agonists ; Endocannabinoids/antagonists & inhibitors ; Male ; Polyunsaturated Alkamides/agonists ; Polyunsaturated Alkamides/antagonists & inhibitors ; Polyunsaturated Alkamides/metabolism ; Rats ; Rats, Inbred SHR ; Rats, Wistar ; Schizophrenia/chemically induced ; Schizophrenia/prevention & control
Czasopismo naukowe
Tytuł :
In vitro and in vivo pharmacological evaluation of the synthetic cannabinoid receptor agonist EG-018.
Autorzy :
Gamage TF; RTI International, 3040 Cornwallis Road, Research Triangle Park, NC 27709, USA.
Barrus DG; RTI International, 3040 Cornwallis Road, Research Triangle Park, NC 27709, USA.
Kevin RC; The Lambert Initiative for Cannabinoid Therapeutics, Brain and Mind Centre, The University of Sydney, Sydney, NSW 2050, Australia; Faculty of Science, School of Psychology, The University of Sydney, Sydney, NSW 2006, Australia.
Finlay DB; Department of Pharmacology and Toxicology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.
Lefever TW; RTI International, 3040 Cornwallis Road, Research Triangle Park, NC 27709, USA.
Patel PR; RTI International, 3040 Cornwallis Road, Research Triangle Park, NC 27709, USA.
Grabenauer MA; RTI International, 3040 Cornwallis Road, Research Triangle Park, NC 27709, USA.
Glass M; Department of Pharmacology and Toxicology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.
McGregor IS; The Lambert Initiative for Cannabinoid Therapeutics, Brain and Mind Centre, The University of Sydney, Sydney, NSW 2050, Australia; Faculty of Science, School of Psychology, The University of Sydney, Sydney, NSW 2006, Australia.
Wiley JL; RTI International, 3040 Cornwallis Road, Research Triangle Park, NC 27709, USA. Electronic address: .
Thomas BF; RTI International, 3040 Cornwallis Road, Research Triangle Park, NC 27709, USA.
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Źródło :
Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 2020 Jun; Vol. 193, pp. 172918. Date of Electronic Publication: 2020 Apr 02.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Behavior, Animal/*drug effects
Body Temperature/*drug effects
Cannabinoid Receptor Agonists/*pharmacokinetics
Locomotion/*drug effects
Microsomes/*drug effects
Receptor, Cannabinoid, CB1/*agonists
Receptor, Cannabinoid, CB2/*agonists
Signal Transduction/*drug effects
Synthetic Drugs/*pharmacokinetics
Animals ; Cannabinoid Receptor Agonists/metabolism ; Cyclic AMP/metabolism ; Dronabinol/pharmacology ; HEK293 Cells ; Humans ; Liver/cytology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Inbred ICR ; Rats ; Rats, Long-Evans ; Receptor, Cannabinoid, CB1/metabolism ; Receptor, Cannabinoid, CB2/metabolism ; Synthetic Drugs/metabolism
Czasopismo naukowe
Tytuł :
Cannabimimetic plants: are they new cannabinoidergic modulators?
Autorzy :
Kumar A; Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Karolinska Institutet, Blickagången 16, Huddinge, Sweden.
Premoli M; Division of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, Brescia, Italy.
Aria F; Division of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, Brescia, Italy.
Bonini SA; Division of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, Brescia, Italy.
Maccarinelli G; Division of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, Brescia, Italy.
Gianoncelli A; Division of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, Brescia, Italy.
Memo M; Division of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, Brescia, Italy.
Mastinu A; Division of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, Brescia, Italy. .
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Źródło :
Planta [Planta] 2019 Jun; Vol. 249 (6), pp. 1681-1694. Date of Electronic Publication: 2019 Mar 15.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Cannabinoid Receptor Modulators/*pharmacology
Endocannabinoids/*pharmacology
Phytochemicals/*pharmacology
Plants/*chemistry
Animals ; Arachidonic Acids/chemistry ; Arachidonic Acids/pharmacology ; Biological Evolution ; Cannabinoid Receptor Agonists/chemistry ; Cannabinoid Receptor Agonists/pharmacology ; Cannabinoid Receptor Modulators/chemistry ; Cannabinoids/chemistry ; Cannabinoids/pharmacology ; Cannabis/chemistry ; Cannabis/genetics ; Cannabis/metabolism ; Dronabinol/analogs & derivatives ; Dronabinol/chemistry ; Dronabinol/pharmacology ; Endocannabinoids/chemistry ; Fruit/chemistry ; Fruit/genetics ; Fruit/metabolism ; Humans ; Phytochemicals/chemistry ; Phytochemicals/therapeutic use ; Plants/genetics ; Plants/metabolism ; Polyunsaturated Alkamides/chemistry ; Polyunsaturated Alkamides/pharmacology ; Receptors, Cannabinoid/metabolism
Czasopismo naukowe
Tytuł :
Single and combined effects of plant-derived and synthetic cannabinoids on cognition and cannabinoid-associated withdrawal signs in mice.
Autorzy :
Myers AM; Center for Substance Abuse Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Siegele PB; Center for Substance Abuse Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Foss JD; Center for Substance Abuse Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Tuma RF; Center for Substance Abuse Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
Ward SJ; Center for Substance Abuse Research, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA.
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Źródło :
British journal of pharmacology [Br J Pharmacol] 2019 May; Vol. 176 (10), pp. 1552-1567. Date of Electronic Publication: 2018 Mar 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cannabidiol/*pharmacology
Cannabinoid Receptor Agonists/*adverse effects
Cannabis/*chemistry
Cognition/*drug effects
Dronabinol/*adverse effects
Substance Withdrawal Syndrome/*prevention & control
Animals ; Cannabidiol/administration & dosage ; Cannabidiol/isolation & purification ; Cannabinoid Receptor Agonists/administration & dosage ; Cannabinoid Receptor Agonists/chemical synthesis ; Cannabinoid Receptor Antagonists/pharmacology ; Dronabinol/administration & dosage ; Dronabinol/chemical synthesis ; Mice ; Mice, Inbred C57BL ; Receptor, Cannabinoid, CB1/agonists ; Receptor, Cannabinoid, CB1/antagonists & inhibitors ; Receptor, Cannabinoid, CB2/agonists ; Substance Withdrawal Syndrome/etiology ; Substance Withdrawal Syndrome/metabolism
Czasopismo naukowe
Tytuł :
Adding more "spice" to the pot: A review of the chemistry and pharmacology of newly emerging heterocyclic synthetic cannabinoid receptor agonists.
Autorzy :
Alam RM; Analytical & Biological Chemistry Research Facility (ABCRF), University College Cork, Cork, Ireland.; School of Chemistry, University College Cork, Cork, Ireland.
Keating JJ; Analytical & Biological Chemistry Research Facility (ABCRF), University College Cork, Cork, Ireland.; School of Chemistry, University College Cork, Cork, Ireland.; School of Pharmacy, University College Cork, Cork, Ireland.
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Źródło :
Drug testing and analysis [Drug Test Anal] 2020 Mar; Vol. 12 (3), pp. 297-315. Date of Electronic Publication: 2020 Jan 25.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Cannabinoid Receptor Agonists/*chemistry
Cannabinoid Receptor Agonists/*pharmacology
Heterocyclic Compounds/*chemistry
Heterocyclic Compounds/*pharmacology
Animals ; Cannabinoid Receptor Agonists/chemical synthesis ; Heterocyclic Compounds/chemical synthesis ; Humans ; Illicit Drugs/chemical synthesis ; Illicit Drugs/chemistry ; Illicit Drugs/pharmacology ; Molecular Structure
Czasopismo naukowe
Tytuł :
Synthetic cannabinoid receptor agonists: classification and nomenclature.
Autorzy :
Potts AJ; NIHR Health Protection Research Unit for Chemical Threats and Hazards, Medical Toxicology Centre, Newcastle University, Newcastle upon Tyne, UK.
Cano C; School of Chemistry, Newcastle University, Newcastle upon Tyne, UK.
Thomas SHL; NIHR Health Protection Research Unit for Chemical Threats and Hazards, Medical Toxicology Centre, Newcastle University, Newcastle upon Tyne, UK.
Hill SL; NIHR Health Protection Research Unit for Chemical Threats and Hazards, Medical Toxicology Centre, Newcastle University, Newcastle upon Tyne, UK.
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Źródło :
Clinical toxicology (Philadelphia, Pa.) [Clin Toxicol (Phila)] 2020 Feb; Vol. 58 (2), pp. 82-98. Date of Electronic Publication: 2019 Sep 16.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Cannabinoid Receptor Agonists/*chemistry
Cannabinoid Receptor Agonists/*classification
Designer Drugs/*chemistry
Designer Drugs/*classification
Receptor, Cannabinoid, CB1/*agonists
Receptor, Cannabinoid, CB2/*agonists
Animals ; Cannabinoid Receptor Agonists/chemical synthesis ; Databases, Pharmaceutical ; Designer Drugs/chemical synthesis ; Humans ; Molecular Structure ; Structure-Activity Relationship ; Terminology as Topic
Czasopismo naukowe
Tytuł :
The Cannabinoid Receptor Agonist WIN55,212-2 Ameliorates Hippocampal Neuronal Damage After Chronic Cerebral Hypoperfusion Possibly Through Inhibiting Oxidative Stress and ASK1-p38 Signaling.
Autorzy :
Wang DP; Department of Neurosurgery, Tong Ji Hospital, Tong Ji University School of Medicine, No. 389, Xincun Road, Putuo District, Shanghai, 200065, China. .
Lv QL; Department of Head and Neck Surgery, Jiangxi Key Laboratory of Translational Cancer Research, Jiangxi Cancer Hospital, Nanchang, 330029, Jiangxi, China.
Lin Q; Department of Pharmacy, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Kang K; Department of Research and Surveillance Evaluation, Shanghai Center for Health Promotion, Shanghai, 200040, China.
Jin KY; Department of Neurosurgery, Tong Ji Hospital, Tong Ji University School of Medicine, No. 389, Xincun Road, Putuo District, Shanghai, 200065, China.
Hai J; Department of Neurosurgery, Tong Ji Hospital, Tong Ji University School of Medicine, No. 389, Xincun Road, Putuo District, Shanghai, 200065, China. .
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Źródło :
Neurotoxicity research [Neurotox Res] 2020 Apr; Vol. 37 (4), pp. 847-856. Date of Electronic Publication: 2019 Dec 05.
Typ publikacji :
Journal Article
MeSH Terms :
Benzoxazines/*therapeutic use
Brain Ischemia/*metabolism
Cannabinoid Receptor Agonists/*therapeutic use
Hippocampus/*metabolism
MAP Kinase Kinase Kinase 5/*metabolism
Morpholines/*therapeutic use
Naphthalenes/*therapeutic use
Oxidative Stress/*physiology
Animals ; Benzoxazines/pharmacology ; Brain Ischemia/drug therapy ; Cannabinoid Receptor Agonists/pharmacology ; Hippocampus/drug effects ; MAP Kinase Kinase Kinase 5/antagonists & inhibitors ; MAP Kinase Signaling System/drug effects ; Male ; Morpholines/pharmacology ; Naphthalenes/pharmacology ; Neurons/drug effects ; Neurons/metabolism ; Oxidative Stress/drug effects ; Random Allocation ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Terpenoids, Cannabimimetic Ligands, beyond the Cannabis Plant.
Autorzy :
Gonçalves ECD; Laboratory of Autoimmunity and Immunopharmacology (LAIF), Department of Health Sciences, Campus Araranguá, Universidade Federal de Santa Catarina, Araranguá 88906-072, Brazil.; Graduate Program of Neuroscience, Center of Biological Sciences, Campus Florianópolis, Universidade Federal de Santa Catarina, Florianópolis 88040-900, Brazil.
Baldasso GM; Laboratory of Autoimmunity and Immunopharmacology (LAIF), Department of Health Sciences, Campus Araranguá, Universidade Federal de Santa Catarina, Araranguá 88906-072, Brazil.
Bicca MA; Neurosurgery Department, Neurosurgery Pain Research institute, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
Paes RS; Laboratory of Autoimmunity and Immunopharmacology (LAIF), Department of Health Sciences, Campus Araranguá, Universidade Federal de Santa Catarina, Araranguá 88906-072, Brazil.
Capasso R; Department of Agricultural Sciences, University of Naples Federico II, 80,055 Portici, Italy.
Dutra RC; Laboratory of Autoimmunity and Immunopharmacology (LAIF), Department of Health Sciences, Campus Araranguá, Universidade Federal de Santa Catarina, Araranguá 88906-072, Brazil.; Graduate Program of Neuroscience, Center of Biological Sciences, Campus Florianópolis, Universidade Federal de Santa Catarina, Florianópolis 88040-900, Brazil.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Mar 29; Vol. 25 (7). Date of Electronic Publication: 2020 Mar 29.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Alzheimer Disease/*drug therapy
Anxiety/*drug therapy
Cannabinoid Receptor Agonists/*chemistry
Cannabis/*chemistry
Cognitive Dysfunction/*drug therapy
Neuroprotective Agents/*chemistry
Schizophrenia/*drug therapy
Alzheimer Disease/physiopathology ; Anxiety/physiopathology ; Bicyclic Monoterpenes/chemistry ; Bicyclic Monoterpenes/isolation & purification ; Bicyclic Monoterpenes/pharmacology ; Cannabidiol/chemistry ; Cannabidiol/isolation & purification ; Cannabidiol/pharmacology ; Cannabinoid Receptor Agonists/classification ; Cannabinoid Receptor Agonists/isolation & purification ; Cannabinoid Receptor Agonists/pharmacology ; Cognitive Dysfunction/physiopathology ; Dronabinol/chemistry ; Dronabinol/isolation & purification ; Dronabinol/pharmacology ; Humans ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/physiopathology ; Neuralgia/drug therapy ; Neuralgia/physiopathology ; Neuroprotective Agents/classification ; Neuroprotective Agents/isolation & purification ; Neuroprotective Agents/pharmacology ; Nootropic Agents/chemistry ; Nootropic Agents/classification ; Nootropic Agents/isolation & purification ; Nootropic Agents/pharmacology ; Schizophrenia/physiopathology ; Sesquiterpenes/chemistry ; Sesquiterpenes/isolation & purification ; Sesquiterpenes/pharmacology ; Terpenes/chemistry ; Terpenes/isolation & purification ; Terpenes/pharmacology
Czasopismo naukowe
Tytuł :
A Novel Alternative in the Treatment of Detrusor Overactivity? In Vivo Activity of O-1602, the Newly Synthesized Agonist of GPR55 and GPR18 Cannabinoid Receptors.
Autorzy :
Wróbel A; Second Department of Gynecology, Medical University of Lublin, 8 Jaczewskiego St., PL-20954 Lublin, Poland.
Szopa A; Chair and Department of Applied and Social Pharmacy, Laboratory of Preclinical Testing, Medical University of Lublin, 1 Chodźki St., PL-20093 Lublin, Poland.
Serefko A; Chair and Department of Applied and Social Pharmacy, Laboratory of Preclinical Testing, Medical University of Lublin, 1 Chodźki St., PL-20093 Lublin, Poland.
Poleszak E; Chair and Department of Applied and Social Pharmacy, Laboratory of Preclinical Testing, Medical University of Lublin, 1 Chodźki St., PL-20093 Lublin, Poland.
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Mar 18; Vol. 25 (6). Date of Electronic Publication: 2020 Mar 18.
Typ publikacji :
Journal Article
MeSH Terms :
Cannabinoid Receptor Agonists*/chemical synthesis
Cannabinoid Receptor Agonists*/chemistry
Cannabinoid Receptor Agonists*/pharmacology
Receptors, G-Protein-Coupled*/agonists
Receptors, G-Protein-Coupled*/metabolism
Cannabidiol/*analogs & derivatives
Receptors, Cannabinoid/*metabolism
Urinary Bladder, Overactive/*drug therapy
Animals ; Cannabidiol/chemical synthesis ; Cannabidiol/chemistry ; Cannabidiol/pharmacology ; Female ; Rats ; Rats, Wistar ; Urinary Bladder, Overactive/metabolism ; Urinary Bladder, Overactive/physiopathology
Czasopismo naukowe
Tytuł :
Phase I metabolism of synthetic cannabinoid receptor agonist PX-1 (5F-APP-PICA) via incubation with human liver microsomes and UHPLC-HRMS.
Autorzy :
Presley BC; Department of Chemistry, Temple University, Philadelphia, PA, USA.
Logan BK; The Center for Forensic Science Research and Education at the Fredric Rieders Family Foundation, Willow Grove, PA, USA.
Jansen-Varnum SA; Department of Chemistry, Temple University, Philadelphia, PA, USA.
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Źródło :
Biomedical chromatography : BMC [Biomed Chromatogr] 2020 Mar; Vol. 34 (3), pp. e4786. Date of Electronic Publication: 2020 Jan 09.
Typ publikacji :
Journal Article
MeSH Terms :
Cannabinoid Receptor Agonists/*pharmacokinetics
Chromatography, High Pressure Liquid/*methods
Indoles/*pharmacokinetics
Mass Spectrometry/*methods
Microsomes, Liver/*metabolism
Cannabinoid Receptor Agonists/analysis ; Cannabinoid Receptor Agonists/chemistry ; Humans ; Indoles/analysis ; Indoles/chemistry ; Models, Molecular
Czasopismo naukowe
Tytuł :
Epilepsy and cannabidiol: a guide to treatment.
Autorzy :
Arzimanoglou A; Paediatric Epilepsy Dpt., University Hospitals of Lyon (HCL), Member of the ERN EpiCARE, and Inserm U1028/CNRS UMR5292, Lyon, France
Brandl U; Department of Neuropediatrics, University Hospital Jena, Jena, Germany
Cross JH; UCL NIHR BRC Great Ormond Street Institute of Child Health, Member of the ERN EpiCARE, London, UK
Gil-Nagel A; Hospital Ruber Internacional, Epilepsy program, Madrid, Spain
Lagae L; University Hospitals KULeuven, Department Development and Regeneration, Section Pediatric Neurology, Member of the ERN EpiCARE, Leuven Belgium
Landmark CJ; Program for Pharmacy, Oslo Metropolitan University and The National Center for Epilepsy and Dept of Pharmacology, Oslo University Hospital, Norway
Specchio N; Rare and Complex Epilepsy Unit, Department on Neuroscience, Bambino Gesu' Children's Hospital, IRCCS, Member of the ERN EpiCARE, Rome, Italy
Nabbout R; Pediatric neurology department, Reference centre for rare epilepsies, Member of the ERN EpiCARE, Necker Enfants Malades University Hospital, APHP, Inserm UMR1163, Institut Imagine, Paris Descartes University, Paris, France
Thiele EA; Department of Neurology, Massachusetts General Hospital, Boston, USA
Gubbay O; Paediatric Epilepsy Dpt., University Hospitals of Lyon (HCL), Member of the ERN EpiCARE, and Inserm U1028 / CNRS UMR5292, Lyon, France
The Cannabinoids International Experts Panel
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Corporate Authors :
Collaborators
Źródło :
Epileptic disorders : international epilepsy journal with videotape [Epileptic Disord] 2020 Feb 01; Vol. 22 (1), pp. 1-14.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Practice Guidelines as Topic*
Cannabidiol/*pharmacology
Cannabinoid Receptor Modulators/*pharmacology
Drug Resistant Epilepsy/*drug therapy
Epilepsies, Myoclonic/*drug therapy
Lennox Gastaut Syndrome/*drug therapy
Cannabidiol/administration & dosage ; Cannabidiol/standards ; Cannabinoid Receptor Modulators/administration & dosage ; Cannabinoid Receptor Modulators/standards ; Humans
Czasopismo naukowe
Tytuł :
Potential combinations of endocannabinoid/endocannabinoid-like compounds and antibiotics against methicillin-resistant Staphylococcus aureus.
Autorzy :
Feldman M; Biofilm Research Laboratory, Faculty of Dental Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Smoum R; The Institute for Drug Research, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, Israel.
Mechoulam R; The Institute for Drug Research, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, Israel.
Steinberg D; Biofilm Research Laboratory, Faculty of Dental Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
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Źródło :
PloS one [PLoS One] 2020 Apr 15; Vol. 15 (4), pp. e0231583. Date of Electronic Publication: 2020 Apr 15 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Anti-Bacterial Agents/*pharmacology
Arachidonic Acids/*pharmacology
Cannabinoid Receptor Agonists/*pharmacology
Endocannabinoids/*pharmacology
Methicillin-Resistant Staphylococcus aureus/*drug effects
Polyunsaturated Alkamides/*pharmacology
Staphylococcal Infections/*drug therapy
Ampicillin/pharmacology ; Ampicillin/therapeutic use ; Anti-Bacterial Agents/therapeutic use ; Arachidonic Acids/therapeutic use ; Biofilms/drug effects ; Cannabinoid Receptor Agonists/therapeutic use ; Drug Evaluation, Preclinical ; Drug Synergism ; Drug Therapy, Combination/methods ; Endocannabinoids/therapeutic use ; Gentamicins/pharmacology ; Gentamicins/therapeutic use ; Humans ; Methicillin Resistance/drug effects ; Microbial Sensitivity Tests ; Polyunsaturated Alkamides/therapeutic use ; Serine/analogs & derivatives ; Serine/pharmacology ; Serine/therapeutic use ; Staphylococcal Infections/microbiology
Czasopismo naukowe
Tytuł :
The use of medical grade cannabis in Italy for drug-resistant epilepsy: a case series.
Autorzy :
Pane C; Department of Neurosciences and Reproductive and Odontostomatological Sciences, University 'Federico II', Via Pansini, 5, 80131, Naples, NA, Italy.
Saccà F; Department of Neurosciences and Reproductive and Odontostomatological Sciences, University 'Federico II', Via Pansini, 5, 80131, Naples, NA, Italy. .
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Źródło :
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology [Neurol Sci] 2020 Mar; Vol. 41 (3), pp. 695-698. Date of Electronic Publication: 2019 Nov 27.
Typ publikacji :
Case Reports; Journal Article
MeSH Terms :
Cannabinoid Receptor Agonists/*pharmacology
Cannabinoids/*pharmacology
Drug Resistant Epilepsy/*drug therapy
Medical Marijuana/*pharmacology
Adolescent ; Adult ; Cannabinoid Receptor Agonists/administration & dosage ; Cannabinoids/administration & dosage ; Child, Preschool ; Female ; Humans ; Italy ; Medical Marijuana/administration & dosage ; Outcome Assessment, Health Care ; Retrospective Studies ; Young Adult
Czasopismo naukowe
Tytuł :
Cannabinoid Augmentation of Exposure-Based Psychotherapy for Obsessive-Compulsive Disorder.
Autorzy :
Kayser RR
Raskin M
Snorrason I
Hezel DM
Haney M
Simpson HB
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Źródło :
Journal of clinical psychopharmacology [J Clin Psychopharmacol] 2020 Mar/Apr; Vol. 40 (2), pp. 207-210.
Typ publikacji :
Letter; Randomized Controlled Trial
MeSH Terms :
Implosive Therapy*
Cannabinoid Receptor Agonists/*pharmacology
Dronabinol/*analogs & derivatives
Obsessive-Compulsive Disorder/*therapy
Adult ; Cannabinoid Receptor Agonists/administration & dosage ; Combined Modality Therapy ; Dronabinol/administration & dosage ; Dronabinol/pharmacology ; Female ; Humans ; Male ; Middle Aged ; Obsessive-Compulsive Disorder/drug therapy ; Outcome Assessment, Health Care ; Pilot Projects ; Young Adult
Raport

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