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Tytuł:
Beta-Caryophyllene, a Cannabinoid Receptor Type 2 Selective Agonist, in Emotional and Cognitive Disorders.
Autorzy:
Ricardi C; Department of Pathology, University of Pisa, 56126 Pisa, Italy.
Barachini S; Hematology Division, Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
Consoli G; Department of Psychiatry, University of Pisa, 56126 Pisa, Italy.
Marazziti D; Department of Psychiatry, University of Pisa, 56126 Pisa, Italy.; UniCamillus, Saint Camillus International University of Health and Medical Sciences, 00151 Rome, Italy.
Polini B; Department of Pathology, University of Pisa, 56126 Pisa, Italy.
Chiellini G; Department of Pathology, University of Pisa, 56126 Pisa, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 Mar 11; Vol. 25 (6). Date of Electronic Publication: 2024 Mar 11.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Cannabinoid Receptor Agonists*/pharmacology
Cannabinoid Receptor Agonists*/therapeutic use
Cognitive Dysfunction*
Polycyclic Sesquiterpenes*
Humans ; Adolescent ; Pandemics ; Post-Acute COVID-19 Syndrome ; Receptors, Cannabinoid ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/therapeutic use ; Receptor, Cannabinoid, CB2
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Evaluating signaling bias for synthetic cannabinoid receptor agonists at the cannabinoid CB 2 receptor.
Autorzy:
Patel M; Department of Pharmacology and Toxicology, University of Otago, Dunedin, New Zealand.
Grimsey NL; Department of Pharmacology and Clinical Pharmacology, School of Medical Sciences, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
Banister SD; Lambert Initiative for Cannabinoid Therapeutics, Brain and Mind Centre, University of Sydney, New South Wales, Australia.; School of Chemistry, Faculty of Science, University of Sydney, New South Wales, Australia.
Finlay DB; Department of Pharmacology and Toxicology, University of Otago, Dunedin, New Zealand.
Glass M; Department of Pharmacology and Toxicology, University of Otago, Dunedin, New Zealand.
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Źródło:
Pharmacology research & perspectives [Pharmacol Res Perspect] 2023 Dec; Vol. 11 (6), pp. e01157.
Typ publikacji:
Journal Article
MeSH Terms:
Cannabinoid Receptor Agonists*/pharmacology
Cannabinoid Receptor Agonists*/chemistry
Cannabinoids*/pharmacology
Humans ; Receptors, Cannabinoid ; Ligands ; HEK293 Cells
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cannabinoid receptor type 1 antagonists alter aspects of risk/reward decision making independent of toluene-mediated effects.
Autorzy:
Braunscheidel KM; Department of Neuroscience, Medical University of South Carolina, MSC 861, 30 Courtenay Drive, Charleston, SC, 29425-5712, USA.
Okas MP; Department of Neuroscience, Medical University of South Carolina, MSC 861, 30 Courtenay Drive, Charleston, SC, 29425-5712, USA.
Floresco SB; Department of Psychology and Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Colombia, V6T 1Z4, Canada.
Woodward JJ; Department of Neuroscience, Medical University of South Carolina, MSC 861, 30 Courtenay Drive, Charleston, SC, 29425-5712, USA. .
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Źródło:
Psychopharmacology [Psychopharmacology (Berl)] 2022 May; Vol. 239 (5), pp. 1337-1347. Date of Electronic Publication: 2021 Jul 22.
Typ publikacji:
Journal Article
MeSH Terms:
Cannabinoid Receptor Antagonists*
Toluene*
Cannabinoid Receptor Agonists/pharmacology ; Decision Making ; Endocannabinoids ; Receptor, Cannabinoid, CB1 ; Receptors, Cannabinoid ; Reward
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Interaction of Synthetic Cannabinoid Receptor Agonists with Cannabinoid Receptor I: Insights into Activation Molecular Mechanism.
Autorzy:
Gavryushov S; Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilova Str. 32, Moscow 119991, Russia.; Institute for Translational Medicine and Biotechnology, Sechenov First Moscow State Medical University, 2-4 Bolshaya Pirogovskaya Str., Moscow 119991, Russia.
Bashilov A; Institute for Translational Medicine and Biotechnology, Sechenov First Moscow State Medical University, 2-4 Bolshaya Pirogovskaya Str., Moscow 119991, Russia.; Skolkovo Institute of Science and Technology, Bolshoy Boulevard 30, Bld. 1, Moscow 121205, Russia.
Cherashev-Tumanov KV; Institute for Translational Medicine and Biotechnology, Sechenov First Moscow State Medical University, 2-4 Bolshaya Pirogovskaya Str., Moscow 119991, Russia.
Kuzmich NN; The Maurice and Vivienne Wohl Institute for Drug Discovery, Weizmann Institute of Science, Rehovot 7610001, Israel.
Burykina TI; Institute for Translational Medicine and Biotechnology, Sechenov First Moscow State Medical University, 2-4 Bolshaya Pirogovskaya Str., Moscow 119991, Russia.
Izotov BN; Institute for Translational Medicine and Biotechnology, Sechenov First Moscow State Medical University, 2-4 Bolshaya Pirogovskaya Str., Moscow 119991, Russia.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Oct 03; Vol. 24 (19). Date of Electronic Publication: 2023 Oct 03.
Typ publikacji:
Journal Article
MeSH Terms:
Cannabinoid Receptor Agonists*/pharmacology
Cannabinoid Receptor Agonists*/chemistry
Molecular Dynamics Simulation*
Ligands ; Receptors, Cannabinoid ; Receptor, Cannabinoid, CB1
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Identification of Novel Cannabinoid CB2 Receptor Agonists from Botanical Compounds and Preliminary Evaluation of Their Anti-Osteoporotic Effects.
Autorzy:
Hu SJ; Department of Pharmacogonosy, School of Pharmaceutical Sciences, Zhejiang University of Traditional Chinese Medicine, Hangzhou 310053, China.
Cheng G; Department of Pharmacogonosy, School of Pharmaceutical Sciences, Zhejiang University of Traditional Chinese Medicine, Hangzhou 310053, China.
Zhou H; Department of Pharmacogonosy, School of Pharmaceutical Sciences, Zhejiang University of Traditional Chinese Medicine, Hangzhou 310053, China.
Zhang Q; Department of Pharmacogonosy, School of Pharmaceutical Sciences, Zhejiang University of Traditional Chinese Medicine, Hangzhou 310053, China.
Zhang QL; Department of Pharmacogonosy, School of Pharmaceutical Sciences, Zhejiang University of Traditional Chinese Medicine, Hangzhou 310053, China.
Wang Y; Zhejiang Traditional Chinese Medicine and Health Industry Group Co., Ltd., Hangzhou 310016, China.
Shen Y; Department of Pharmacogonosy, School of Pharmaceutical Sciences, Zhejiang University of Traditional Chinese Medicine, Hangzhou 310053, China.
Lian CX; Department of Pharmacogonosy, School of Pharmaceutical Sciences, Zhejiang University of Traditional Chinese Medicine, Hangzhou 310053, China.
Ma XQ; Department of Pharmaceutical Analysis, School of Pharmacy Key Laboratory of Hui Ethnic Medicine Modernization, Ministry of Education, Ningxia Medical University, Yinchuan 750004, China.
Zhang QY; Department of Pharmacogonosy, School of Pharmaceutical Sciences, Zhejiang University of Traditional Chinese Medicine, Hangzhou 310053, China.; Department of Pharmacogonosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
Qin LP; Department of Pharmacogonosy, School of Pharmaceutical Sciences, Zhejiang University of Traditional Chinese Medicine, Hangzhou 310053, China.; Department of Pharmacogonosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Jan 21; Vol. 27 (3). Date of Electronic Publication: 2022 Jan 21.
Typ publikacji:
Journal Article
MeSH Terms:
Cannabinoid Receptor Agonists/*pharmacology
Drug Evaluation, Preclinical/*methods
Receptor, Cannabinoid, CB2/*agonists
Animals ; Anti-Inflammatory Agents/pharmacology ; Cannabinoid Receptor Agonists/chemistry ; Cannabinoid Receptor Modulators/pharmacology ; Cannabinoids/pharmacology ; China ; HEK293 Cells ; Humans ; Ligands ; Mice ; Models, Molecular ; Molecular Docking Simulation ; RAW 264.7 Cells ; Receptor, Cannabinoid, CB2/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cannabinoid Receptor 1 Agonist ACEA and Cannabinoid Receptor 2 Agonist GW833972A Attenuates Cell-Mediated Immunity by Different Biological Mechanisms.
Autorzy:
Takheaw N; Division of Clinical Immunology, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.; Biomedical Technology Research Center, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
Jindaphun K; Division of Clinical Immunology, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.; Biomedical Technology Research Center, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
Pata S; Division of Clinical Immunology, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.; Biomedical Technology Research Center, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
Laopajon W; Division of Clinical Immunology, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.; Biomedical Technology Research Center, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
Kasinrerk W; Division of Clinical Immunology, Department of Medical Technology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.; Biomedical Technology Research Center, National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
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Źródło:
Cells [Cells] 2023 Mar 09; Vol. 12 (6). Date of Electronic Publication: 2023 Mar 09.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cannabinoid Receptor Agonists*/pharmacology
CD8-Positive T-Lymphocytes*
Immunity, Cellular ; Receptors, Cannabinoid
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Cannabinoid Ligand Arachidonyl-2'-Chloroethylamide (ACEA) Ameliorates Depressive and Overactive Bladder Symptoms in a Corticosterone-Induced Female Wistar Rat Model.
Autorzy:
Zapała Ł; Clinic of General, Oncological and Functional Urology, Medical University of Warsaw, Lindleya 4, 02-005 Warsaw, Poland.
Niemczyk G; Clinic of General, Oncological and Functional Urology, Medical University of Warsaw, Lindleya 4, 02-005 Warsaw, Poland.
Zapała P; Clinic of General, Oncological and Functional Urology, Medical University of Warsaw, Lindleya 4, 02-005 Warsaw, Poland.
Wdowiak A; Chair of Obstetrics and Gynecology, Faculty of Health Sciences, Medical University of Lublin, 4-6 Staszica St., 20-081 Lublin, Poland.
Bojar I; Department of Women's Health, Institute of Rural Health in Lublin, Ul. Jaczewskiego 2, 20-090 Lublin, Poland.
Kluz T; Department of Gynecology, Gynecology Oncology and Obstetrics, Institute of Medical Sciences, Medical College of Rzeszow University, 16c Rejtana Street, 35-959 Rzeszow, Poland.
Szopa A; Department of Clinical Pharmacy and Pharmaceutical Care, Faculty of Pharmacy, Medical University of Lublin, 1 Chodźki Street, 20-093 Lublin, Poland.
Serefko A; Department of Clinical Pharmacy and Pharmaceutical Care, Faculty of Pharmacy, Medical University of Lublin, 1 Chodźki Street, 20-093 Lublin, Poland.
Radziszewski P; Clinic of General, Oncological and Functional Urology, Medical University of Warsaw, Lindleya 4, 02-005 Warsaw, Poland.
Wróbel A; Second Department of Gynecology, Medical University of Lublin, Jaczewskiego 8, 20-090 Lublin, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Feb 14; Vol. 24 (4). Date of Electronic Publication: 2023 Feb 14.
Typ publikacji:
Journal Article
MeSH Terms:
Cannabinoid Receptor Agonists*/pharmacology
Cannabinoid Receptor Agonists*/therapeutic use
Cannabinoids*/therapeutic use
Receptor, Cannabinoid, CB1*/agonists
Urinary Bladder, Overactive*/drug therapy
Arachidonic Acids*/pharmacology
Arachidonic Acids*/therapeutic use
Animals ; Female ; Rats ; Brain-Derived Neurotrophic Factor/therapeutic use ; Corticosterone ; Ligands ; Rats, Wistar
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Chemistry and Pharmacology of Delta-8-Tetrahydrocannabinol.
Autorzy:
Abdel-Kader MS; Department of Pharmacognosy, College of Pharmacy, Prince Sattam bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.; Pharmacognosy Department, Faculty of Pharmacy, Alexandria University, Alexandria 21215, Egypt.
Radwan MM; Pharmacognosy Department, Faculty of Pharmacy, Alexandria University, Alexandria 21215, Egypt.; National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA.
Metwaly AM; Pharmacognosy and Medicinal Plants Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt.
Eissa IH; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo 11884, Egypt.
Hazekamp A; Hazekamp Herbal Consulting, 6420 Leiden, The Netherlands.
ElSohly MA; National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA.; Department of Pharmaceutics and Drug Delivery, School of Pharmacy, University of Mississippi, University, MS 38677, USA.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2024 Mar 11; Vol. 29 (6). Date of Electronic Publication: 2024 Mar 11.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Cannabinoids*/pharmacology
Cannabis*
Hallucinogens*/pharmacology
Dronabinol/*analogs & derivatives
Humans ; Dronabinol/pharmacology ; Cannabinoid Receptor Agonists/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Activation of Cannabinoid Type 2 Receptor in Microglia Reduces Neuroinflammation through Inhibiting Aerobic Glycolysis to Relieve Hypertension.
Autorzy:
Shan R; Department of Physiology, Hebei Medical University, Shijiazhuang 050017, China.
Zhang Y; Department of Physiology, Hebei Medical University, Shijiazhuang 050017, China.
Shi Y; Department of Physiology, Hebei Medical University, Shijiazhuang 050017, China.
Wang X; Department of Physiology, Hebei Medical University, Shijiazhuang 050017, China.
Wang X; Department of Physiology, Hebei Medical University, Shijiazhuang 050017, China.
Ma G; Department of Physiology, Hebei Medical University, Shijiazhuang 050017, China.
Li Q; Department of Physiology, Hebei Medical University, Shijiazhuang 050017, China.; Cardiovascular Research Platform, Institute of Medicine and Health, Hebei Medical University, Shijiazhuang 050017, China.
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Źródło:
Biomolecules [Biomolecules] 2024 Mar 11; Vol. 14 (3). Date of Electronic Publication: 2024 Mar 11.
Typ publikacji:
Journal Article
MeSH Terms:
Cannabinoids*/pharmacology
Hypertension*/drug therapy
Hypertension*/metabolism
Rats ; Mice ; Animals ; Neuroinflammatory Diseases ; Tumor Necrosis Factor-alpha/metabolism ; Microglia/metabolism ; Interleukin-6/metabolism ; Receptor, Cannabinoid, CB2/genetics ; Receptor, Cannabinoid, CB2/metabolism ; Cannabinoid Receptor Agonists/pharmacology ; Rats, Inbred SHR ; Glycolysis ; Lactic Acid/metabolism ; Norepinephrine/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Classical cannabinoid receptors as target in cancer-induced bone pain: a systematic review, meta-analysis and bioinformatics validation.
Autorzy:
Zeng F; Department of Oncology and Metabolism, University of Sheffield, Medical School, Beech Hill Road, Sheffield, S10 2RX, UK.
Wade A; Department of Oncology and Metabolism, University of Sheffield, Medical School, Beech Hill Road, Sheffield, S10 2RX, UK.
Harbert K; Department of Oncology and Metabolism, University of Sheffield, Medical School, Beech Hill Road, Sheffield, S10 2RX, UK.
Patel S; Department of Oncology and Metabolism, University of Sheffield, Medical School, Beech Hill Road, Sheffield, S10 2RX, UK.
Holley JS; Department of Oncology and Metabolism, University of Sheffield, Medical School, Beech Hill Road, Sheffield, S10 2RX, UK.
Dehghanpuor CK; Department of Oncology and Metabolism, University of Sheffield, Medical School, Beech Hill Road, Sheffield, S10 2RX, UK.
Hopwood T; Department of Oncology and Metabolism, University of Sheffield, Medical School, Beech Hill Road, Sheffield, S10 2RX, UK.
Marino S; Department of Physiology and Cell Biology, University of Arkansas for Medical Sciences (UAMS), BioMed II, 238-2, Little Rock, AR, USA.
Sophocleous A; Department of Life Sciences, School of Sciences, European University Cyprus, 6 Diogenes Street, 1516, Nicosia, Cyprus. .
Idris AI; Department of Oncology and Metabolism, University of Sheffield, Medical School, Beech Hill Road, Sheffield, S10 2RX, UK. .
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Źródło:
Scientific reports [Sci Rep] 2024 Mar 09; Vol. 14 (1), pp. 5782. Date of Electronic Publication: 2024 Mar 09.
Typ publikacji:
Systematic Review; Meta-Analysis; Journal Article
MeSH Terms:
Osteolysis*/drug therapy
Cannabinoids*/pharmacology
Cannabinoids*/therapeutic use
Cancer Pain*/drug therapy
Cancer Pain*/etiology
Neoplasms*/drug therapy
Male ; Rats ; Humans ; Mice ; Animals ; Receptors, Cannabinoid ; Cannabinoid Receptor Agonists ; Receptor, Cannabinoid, CB2 ; Receptor, Cannabinoid, CB1
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Functional Selectivity of Cannabinoid Type 1 G Protein-Coupled Receptor Agonists in Transactivating Glycosylated Receptors on Cancer Cells to Induce Epithelial-Mesenchymal Transition Metastatic Phenotype.
Autorzy:
Bunsick DA; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 3N6, Canada.
Matsukubo J; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 3N6, Canada.; Faculty of Medicine, University of Ottawa, Roger Guindon Hall, 451 Smyth Rd #2044, Ottawa, ON K1H 8M5, Canada.
Aldbai R; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 3N6, Canada.
Baghaie L; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 3N6, Canada.
Szewczuk MR; Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON K7L 3N6, Canada.
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Źródło:
Cells [Cells] 2024 Mar 08; Vol. 13 (6). Date of Electronic Publication: 2024 Mar 08.
Typ publikacji:
Journal Article
MeSH Terms:
Cannabinoids*/pharmacology
Neoplasms*
Cannabinoid Receptor Agonists/pharmacology ; Matrix Metalloproteinase 9/metabolism ; Vimentin/metabolism ; Ligands ; Glycosylation ; Neuraminidase/metabolism ; Receptors, G-Protein-Coupled/metabolism ; Epithelial-Mesenchymal Transition ; Cadherins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Efficient Capture of Cannabis Terpenes in Olive Oil during Microwave-Assisted Cannabinoid Decarboxylation.
Autorzy:
Boffa L; Dipartimento di Scienza e Tecnologia del Farmaco, University of Turin, Via P. Giuria 9, 10125 Turin, Italy.
Binello A; Dipartimento di Scienza e Tecnologia del Farmaco, University of Turin, Via P. Giuria 9, 10125 Turin, Italy.
Cravotto G; Dipartimento di Scienza e Tecnologia del Farmaco, University of Turin, Via P. Giuria 9, 10125 Turin, Italy.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2024 Feb 18; Vol. 29 (4). Date of Electronic Publication: 2024 Feb 18.
Typ publikacji:
Journal Article
MeSH Terms:
Cannabinoids*/chemistry
Cannabis*/chemistry
Sesquiterpenes*/chemistry
Hallucinogens*
Polycyclic Sesquiterpenes*
Terpenes/chemistry ; Olive Oil ; Decarboxylation ; Microwaves ; Monoterpenes/chemistry ; Cannabinoid Receptor Agonists
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Differences in prescribed medicinal cannabis use by cannabinoid product composition: Findings from the cannabis as medicine survey 2020 (CAMS-20) Australia-wide study.
Autorzy:
Trevitt BT; Drug and Alcohol Services, South Eastern Sydney Local Health District, Sydney, NSW, Australia.; School of Public Health and Community Medicine, UNSW Sydney, Sydney, Australia.
Bailey S; Faculty of Medicine and Health, The Matilda Centre for Research in Mental Health and Substance Use, The University of Sydney, Camperdown, Australia.
Mills L; Drug and Alcohol Services, South Eastern Sydney Local Health District, Sydney, NSW, Australia.; Speciality Addiction Medicine, Faculty Medicine and Health, University of Sydney, Camperdown, NSW, Australia.; Drug and Alcohol Clinical Research and Improvement Network, St Leonards, NSW, Australia.
Arkell TR; Centre for Human Psychopharmacology, Swinburne University of Technology, Hawthorn, VIC, Australia.
Suraev A; The University of Sydney, Lambert Initiative for Cannabinoid Therapeutics, Sydney, NSW, Australia.; The University of Sydney, Faculty of Science, School of Psychology, Sydney, NSW, Australia.; The University of Sydney, Brain and Mind Centre, Sydney, NSW, Australia.
McGregor IS; The University of Sydney, Lambert Initiative for Cannabinoid Therapeutics, Sydney, NSW, Australia.; The University of Sydney, Faculty of Science, School of Psychology, Sydney, NSW, Australia.; The University of Sydney, Brain and Mind Centre, Sydney, NSW, Australia.
Lintzeris N; Drug and Alcohol Services, South Eastern Sydney Local Health District, Sydney, NSW, Australia.; Speciality Addiction Medicine, Faculty Medicine and Health, University of Sydney, Camperdown, NSW, Australia.; Drug and Alcohol Clinical Research and Improvement Network, St Leonards, NSW, Australia.
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Źródło:
PloS one [PLoS One] 2024 Feb 14; Vol. 19 (2), pp. e0297092. Date of Electronic Publication: 2024 Feb 14 (Print Publication: 2024).
Typ publikacji:
Journal Article
MeSH Terms:
Cannabinoids*/adverse effects
Cannabinoids*/analysis
Cannabis*
Medical Marijuana*/adverse effects
Hallucinogens*
Cannabidiol*
Humans ; Male ; Female ; Cross-Sectional Studies ; Australia ; Pain/chemically induced ; Cannabinoid Receptor Agonists ; Dronabinol/adverse effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Structure-Based Virtual Screening and Molecular Dynamics Simulation Assessments of Depsidones as Possible Selective Cannabinoid Receptor Type 2 Agonists.
Autorzy:
Mohamed GA; Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Omar AM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.; Center for Artificial Intelligence in Precision Medicines, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
AlKharboush DF; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Fallatah MA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.; King Abdulaziz Medical City, Jeddah 21423, Saudi Arabia.
Sindi IA; Department of Biology, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
El-Agamy DS; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
Ibrahim SRM; Department of Chemistry, Preparatory Year Program, Batterjee Medical College, Jeddah 21442, Saudi Arabia.; Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2023 Feb 13; Vol. 28 (4). Date of Electronic Publication: 2023 Feb 13.
Typ publikacji:
Journal Article
MeSH Terms:
Cannabinoid Receptor Agonists*/chemistry
Molecular Dynamics Simulation*
Receptor, Cannabinoid, CB2 ; Acetylcholinesterase ; Ligands ; Receptor, Cannabinoid, CB1 ; Molecular Docking Simulation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Docking and Molecular Dynamic Investigations of Phenylspirodrimanes as Cannabinoid Receptor-2 Agonists.
Autorzy:
Omar AM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo 11884, Egypt.; Center for Artificial Intelligence in Precision Medicines, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Aljahdali AS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Safo MK; Department of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth University, 800 East Leigh Street, Richmond, VA 23298, USA.; Institute for Structural Biology, Drug Discovery and Development, Virginia Commonwealth University, 800 East Leigh Street, Richmond, VA 23298, USA.
Mohamed GA; Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Ibrahim SRM; Department of Chemistry, Preparatory Year Program, Batterjee Medical College, Jeddah 21442, Saudi Arabia.; Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Dec 21; Vol. 28 (1). Date of Electronic Publication: 2022 Dec 21.
Typ publikacji:
Journal Article
MeSH Terms:
Cannabinoid Receptor Agonists*/pharmacology
Cannabinoid Receptor Agonists*/chemistry
Molecular Dynamics Simulation*
Receptor, Cannabinoid, CB2*/metabolism
Terpenes*/chemistry
Terpenes*/pharmacology
Binding Sites ; Ligands ; Molecular Docking Simulation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Trends in hospital presentations following analytically confirmed synthetic cannabinoid receptor agonist exposure before and after implementation of the 2016 UK Psychoactive Substances Act.
Autorzy:
Craft S; Addiction and Mental Health Group (AIM), Department of Psychology, University of Bath, Bath, UK.
Dunn M; Translational and Clinical Research Institute, Newcastle University, Newcastle, UK.
Vidler D; Translational and Clinical Research Institute, Newcastle University, Newcastle, UK.
Officer J; Scottish Police Authority Forensic Services, Edinburgh, UK.
Blagbrough IS; Department of Pharmacy and Pharmacology, University of Bath, Bath, UK.
Pudney CR; Department of Biology and Biochemistry, University of Bath, Bath, UK.
Henderson G; School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK.
Abouzeid A; Blackpool Teaching Hospitals NHS Foundation Trust, Blackpool, Blackpool, UK.
Dargan PI; Guy's and St Thomas' NHS Foundation Trust, London, UK.
Eddleston M; Royal Infirmary of Edinburgh, Edinburgh, UK.
Cooper J; Aberdeen Royal Infirmary, Aberdeen, UK.
Hill SL; Newcastle Hospitals NHS Foundation Trust, Royal Victoria Infirmary, Newcastle, UK.
Roper C; Translational and Clinical Research Institute, Newcastle University, Newcastle, UK.
Freeman TP; Addiction and Mental Health Group (AIM), Department of Psychology, University of Bath, Bath, UK.
Thomas SHL; Translational and Clinical Research Institute, Newcastle University, Newcastle, UK.
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Źródło:
Addiction (Abingdon, England) [Addiction] 2022 Nov; Vol. 117 (11), pp. 2899-2906. Date of Electronic Publication: 2022 Jun 19.
Typ publikacji:
Journal Article; Observational Study; Research Support, Non-U.S. Gov't
MeSH Terms:
Cannabinoid Receptor Agonists*/adverse effects
Personality*
Chromatography, Liquid ; Female ; Hospitals ; Humans ; Male ; United Kingdom/epidemiology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
UR-144, synthetic cannabinoid receptor agonist, induced cardiomyoblast toxicity mechanism comprises cytoplasmic Ca and DAPK1 related autophagy and necrosis.
Autorzy:
Akar M; Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Istanbul University, Istanbul, Turkey.
Ercin M; Department of Biology, Faculty of Science, Istanbul University, Istanbul, Turkey.
Boran T; Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Istanbul University, Istanbul, Turkey.
Gezginci-Oktayoglu S; Department of Biology, Faculty of Science, Istanbul University, Istanbul, Turkey.
Özhan G; Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Istanbul University, Istanbul, Turkey.
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Źródło:
Toxicology mechanisms and methods [Toxicol Mech Methods] 2023 Jan; Vol. 33 (1), pp. 56-64. Date of Electronic Publication: 2022 Jun 02.
Typ publikacji:
Journal Article
MeSH Terms:
Cannabinoid Receptor Agonists*/pharmacology
Troponin T*/pharmacology
Humans ; Reactive Oxygen Species ; Apoptosis ; Autophagy ; Necrosis/chemically induced ; Cardiotoxicity ; Death-Associated Protein Kinases/metabolism ; Death-Associated Protein Kinases/pharmacology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Discovery of a pyrano[2,3-b]pyridine derivative YX-2102 as a cannabinoid receptor 2 agonist for alleviating lung fibrosis.
Autorzy:
Liu T; College of Pharmacy, Third Military Medical University, Chongqing, 400038, China.
Gu J; College of Pharmacy, Third Military Medical University, Chongqing, 400038, China.
Yuan Y; College of Pharmacy, Third Military Medical University, Chongqing, 400038, China.
Yang Q; College of Pharmacy, Third Military Medical University, Chongqing, 400038, China.
Zheng PF; College of Pharmacy, Third Military Medical University, Chongqing, 400038, China.
Shan C; College of Pharmacy, Third Military Medical University, Chongqing, 400038, China.
Wang F; College of Pharmacy, Third Military Medical University, Chongqing, 400038, China.
Li H; College of Pharmacy, Third Military Medical University, Chongqing, 400038, China.
Xie XQ; Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
Chen XH; College of Pharmacy, Third Military Medical University, Chongqing, 400038, China. .
Ouyang Q; College of Pharmacy, Third Military Medical University, Chongqing, 400038, China. .
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Źródło:
Journal of translational medicine [J Transl Med] 2022 Dec 06; Vol. 20 (1), pp. 565. Date of Electronic Publication: 2022 Dec 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cannabinoid Receptor Agonists*
Pulmonary Fibrosis*/drug therapy
Animals ; Rats ; Receptors, Cannabinoid
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
N -[1,3-Dialkyl(aryl)-2-oxoimidazolidin-4-ylidene]-aryl(alkyl)sulphonamides as Novel Selective Human Cannabinoid Type 2 Receptor (hCB2R) Ligands; Insights into the Mechanism of Receptor Activation/Deactivation.
Autorzy:
Gianquinto E; Department of Drug Science and Technology, University of Torino, 10125 Torino, Italy.
Sodano F; Department of Drug Science and Technology, University of Torino, 10125 Torino, Italy.; Department of Pharmacy, 'Federico II' University of Naples, 80131 Naples, Italy.
Rolando B; Department of Drug Science and Technology, University of Torino, 10125 Torino, Italy.
Kostrzewa M; National Research Council of Italy, Institute of Biomolecular Chemistry, 80078 Pozzuoli, Italy.
Allarà M; National Research Council of Italy, Institute of Biomolecular Chemistry, 80078 Pozzuoli, Italy.
Mahmoud AM; National Research Council of Italy, Institute of Biomolecular Chemistry, 80078 Pozzuoli, Italy.
Kumar P; National Research Council of Italy, Institute of Biomolecular Chemistry, 80078 Pozzuoli, Italy.
Spyrakis F; Department of Drug Science and Technology, University of Torino, 10125 Torino, Italy.
Ligresti A; National Research Council of Italy, Institute of Biomolecular Chemistry, 80078 Pozzuoli, Italy.
Chegaev K; Department of Drug Science and Technology, University of Torino, 10125 Torino, Italy.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2022 Nov 23; Vol. 27 (23). Date of Electronic Publication: 2022 Nov 23.
Typ publikacji:
Journal Article
MeSH Terms:
Cannabinoid Receptor Agonists*/chemistry
Cannabinoids*
Humans ; Protein Binding ; Ligands ; Structure-Activity Relationship ; Sulfonamides ; Receptor, Cannabinoid, CB2 ; Receptor, Cannabinoid, CB1
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Clinical features associated with ADB-BUTINACA exposure in patients attending emergency departments in England.
Autorzy:
King A; Newcastle Hospitals NHS Foundation Trust, Newcastle, United Kingdom.
Hill SL; Newcastle Hospitals NHS Foundation Trust, Newcastle, United Kingdom.; Translational and Clinical Research Institute, Newcastle University, Newcastle, United Kingdom.
Pucci M; University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom.
Bailey G; Imperial College Healthcare NHS Trust, London, United Kingdom.
Keating L; Royal Berkshire NHS Foundation Trust, Reading, United Kingdom.
Macfarlane R; Epsom and St Helier NHS Trust, Epsom, United Kingdom.
Cantle F; King's College Hospital NHS Foundation Trust, London, United Kingdom.
Hudson S; Sport and Specialised Analytical Services, Fordham, United Kingdom.
Thomas SHL; Newcastle Hospitals NHS Foundation Trust, Newcastle, United Kingdom.; Translational and Clinical Research Institute, Newcastle University, Newcastle, United Kingdom.
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Źródło:
Clinical toxicology (Philadelphia, Pa.) [Clin Toxicol (Phila)] 2022 Oct; Vol. 60 (10), pp. 1094-1098. Date of Electronic Publication: 2022 Aug 09.
Typ publikacji:
Journal Article
MeSH Terms:
Cannabinoid Receptor Agonists*
Crack Cocaine*
Adult ; Male ; Humans ; Adolescent ; Young Adult ; Middle Aged ; Heroin ; Pregabalin ; Emergency Service, Hospital ; England/epidemiology ; Hallucinations ; Benzodiazepines ; Seizures
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
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