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    Wyświetlanie 1-8 z 8
    Tytuł:
    Non-Coding Variants in BRCA1 and BRCA2 Genes: Potential Impact on Breast and Ovarian Cancer Predisposition.
    Autorzy:
    Santana Dos Santos E; A.C.Camargo Cancer Center, São Paulo 01509-010, Brazil. .; Department of Oncology, Center for Translational Oncology, Cancer Institute of the State of São Paulo-ICESP, São Paulo 01246-000, Brazil. .; Department of Genetics, Institut Curie, 75005 Paris, France. .
    Lallemand F; Department of Genetics, Institut Curie, 75005 Paris, France. .; Institut Curie, Paris Sciences Lettres Research University, 75230 Paris, France. .
    Burke L; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia. .
    Stoppa-Lyonnet D; Department of Genetics, Institut Curie, 75005 Paris, France. .; Department of Genetics at Institut Curie, Université Paris Descartes, 75006 Paris, France. .; INSERM U830, Institut Curie, 75248 Paris, France. .
    Brown M; School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD 4072, Australia. .
    Caputo SM; Department of Genetics, Institut Curie, 75005 Paris, France. sandrine.caputo@curie.fr.; Institut Curie, Paris Sciences Lettres Research University, 75230 Paris, France. sandrine.caputo@curie.fr.
    Rouleau E; Institut Gustave Roussy, 94805 Villejuif, France. .
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    Źródło:
    Cancers [Cancers (Basel)] 2018 Nov 16; Vol. 10 (11). Date of Electronic Publication: 2018 Nov 16.
    Typ publikacji:
    Journal Article; Review
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    The high protein expression of FOXO3, but not that of FOXO1, is associated with markers of good prognosis.
    Autorzy:
    Lallemand F; Service de génétique, unité de pharmacogénomique, Institut Curie, 26 rue d'Ulm, Paris, France.; Paris Sciences Lettres Research University, Paris, France.
    Vacher S; Service de génétique, unité de pharmacogénomique, Institut Curie, 26 rue d'Ulm, Paris, France.; Paris Sciences Lettres Research University, Paris, France.
    de Koning L; Translational Research Department, Institut Curie, PSL Research University, 26 rue d'Ulm, Paris, France.
    Petitalot A; Service de génétique, unité de pharmacogénomique, Institut Curie, 26 rue d'Ulm, Paris, France.; Paris Sciences Lettres Research University, Paris, France.; Service de génétique, unité de génétique constitutionnelle, Institut Curie, 26 rue d'Ulm, Paris, France.
    Briaux A; Service de génétique, unité de pharmacogénomique, Institut Curie, 26 rue d'Ulm, Paris, France.; Paris Sciences Lettres Research University, Paris, France.
    Driouch K; Service de génétique, unité de pharmacogénomique, Institut Curie, 26 rue d'Ulm, Paris, France.; Paris Sciences Lettres Research University, Paris, France.
    Callens C; Service de génétique, unité de pharmacogénomique, Institut Curie, 26 rue d'Ulm, Paris, France.; Paris Sciences Lettres Research University, Paris, France.
    Schnitzler A; Service de génétique, unité de pharmacogénomique, Institut Curie, 26 rue d'Ulm, Paris, France.; Paris Sciences Lettres Research University, Paris, France.
    Lecerf C; Translational Research Department, Institut Curie, PSL Research University, 26 rue d'Ulm, Paris, France.
    Oulie-Bard F; Translational Research Department, Institut Curie, PSL Research University, 26 rue d'Ulm, Paris, France.
    Barbet A; Translational Research Department, Institut Curie, PSL Research University, 26 rue d'Ulm, Paris, France.
    Vincent A; Centre de Recherche en Cancérologie de Lyon (CRCL)/INSERM U1052-CNRS UMR5286 Centre Léon Bérard, 28 Rue Laënnec, 69373 Cedex 08, Lyon, France., Lyon, France.
    Zinn-Justin S; Laboratoire de Biologie Structurale et Radiobiologie, Institute for Integrative Biology of the Cell (CEA, CNRS, University Paris South), University Paris-Saclay, Gif-sur-Yvette, France.
    Lopez BS; CNRS UMR 8200, Gustave Roussy Cancer Institute, Université Paris-Saclay, équipe labélisée par la Ligue contre le cancer, Villejuif, France.; Institut Cochin, INSERM U1016, UMR 8104 CNRS, Université de Paris, 75014, Paris, France.
    Lidereau R; Service de génétique, unité de pharmacogénomique, Institut Curie, 26 rue d'Ulm, Paris, France.
    Bieche I; Service de génétique, unité de pharmacogénomique, Institut Curie, 26 rue d'Ulm, Paris, France.; INSERM U1016, Université Paris Descartes, 4 avenue de l'observatoire, Paris, France.
    Caputo SM; Paris Sciences Lettres Research University, Paris, France. sandrine.caputo@curie.fr.; Service de génétique, unité de génétique constitutionnelle, Institut Curie, 26 rue d'Ulm, Paris, France. sandrine.caputo@curie.fr.
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    Źródło:
    Scientific reports [Sci Rep] 2020 Apr 24; Vol. 10 (1), pp. 6920. Date of Electronic Publication: 2020 Apr 24.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Biomarkers, Tumor/*metabolism
    Breast Neoplasms/*diagnosis
    Forkhead Box Protein O1/*metabolism
    Forkhead Box Protein O3/*metabolism
    Adult ; Aged ; Aged, 80 and over ; Apoptosis/genetics ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Cell Cycle/genetics ; Cell Proliferation/genetics ; DNA Damage/genetics ; DNA Repair/genetics ; Female ; Forkhead Box Protein O1/genetics ; Forkhead Box Protein O3/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Kaplan-Meier Estimate ; Middle Aged ; Phosphatidylinositol 3-Kinases/metabolism ; Prognosis ; Proto-Oncogene Proteins c-akt/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    HRness in Breast and Ovarian Cancers.
    Autorzy:
    Santana Dos Santos E; Department of Medical Biology and Pathology, Gustave Roussy, Cancer Genetics Laboratory, Gustave Roussy, 94800 Villejuif, France.; Department of Clinical Oncology, A.C. Camargo Cancer Center, São Paulo 01509-010, Brazil.
    Lallemand F; Department of Genetics, Institut Curie, 75005 Paris, France.; PSL Research University, 75005 Paris, France.
    Petitalot A; Department of Genetics, Institut Curie, 75005 Paris, France.; PSL Research University, 75005 Paris, France.
    Caputo SM; Department of Genetics, Institut Curie, 75005 Paris, France.; PSL Research University, 75005 Paris, France.
    Rouleau E; Department of Medical Biology and Pathology, Gustave Roussy, Cancer Genetics Laboratory, Gustave Roussy, 94800 Villejuif, France.
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    Źródło:
    International journal of molecular sciences [Int J Mol Sci] 2020 May 28; Vol. 21 (11). Date of Electronic Publication: 2020 May 28.
    Typ publikacji:
    Journal Article; Review
    MeSH Terms:
    Carcinogenesis*
    DNA Damage*
    DNA Repair*
    Homologous Recombination*
    Breast Neoplasms/*genetics
    Ovarian Neoplasms/*genetics
    Antineoplastic Agents/pharmacology ; Apoptosis ; Biomarkers, Tumor/genetics ; Cell Cycle ; Female ; Genes, BRCA1 ; Genes, BRCA2 ; Genetic Predisposition to Disease ; Germ-Line Mutation ; Humans ; Mutation
    SCR Disease Name:
    Breast Cancer, Familial
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    5' Region Large Genomic Rearrangements in the BRCA1 Gene in French Families: Identification of a Tandem Triplication and Nine Distinct Deletions with Five Recurrent Breakpoints.
    Autorzy:
    Caputo SM; Department of Genetics, Institut Curie, F-75248 Paris, France.; Institut Curie, PSL Research University, F-75005 Paris, France.
    Telly D; Laboratoire d'Oncogénétique, Institut Claudius Regaud, IUCT-O, F-31059 Toulouse, France.
    Briaux A; Department of Genetics, Institut Curie, F-75248 Paris, France.; Institut Curie, PSL Research University, F-75005 Paris, France.
    Sesen J; Department of Neurosurgery, Boston Children's Hospital, Boston, MA 02115, USA.
    Ceppi M; Roche Innovation Center Basel (RICB), Roche Pharma Research and Early Development, CH-4052 Basel, Switzerland.
    Bonnet F; Laboratoire de Génétique Constitutionnelle et INSERM U916 VINCO, Institut Bergonié, CEDEX, F-33076 Bordeaux, France.
    Bourdon V; Laboratoire d'Oncogénétique Moléculaire, Département de Biologie du Cancer, Institut Paoli-Calmettes, F-13273 Marseille, France.
    Coulet F; Department of Genetics, Pitié-Salpêtriere Hospital, Assistance Publique-Hopitaux de Paris, Sorbonne University, F-75013 Paris, France.
    Castera L; Laboratoire de Biologie et de Génétique du Cancer, CLCC François Baclesse, INSERM 1079 Centre Normand de Génomique et de Médecine Personnalisée, F-14076 Caen, France.
    Delnatte C; Service de Génétique Médicale, Unité de Génétique Moléculaire, CHU Nantes, F-44093 Nantes, France.
    Hardouin A; Laboratoire de Biologie et de Génétique du Cancer, CLCC François Baclesse, INSERM 1079 Centre Normand de Génomique et de Médecine Personnalisée, F-14076 Caen, France.
    Mazoyer S; Centre de Recherche en Neurosciences de Lyon, INSERM, U1028, CNRS, UMR5292, Université de Lyon, F-69008 Lyon, France.
    Schultz I; Centre Paul Strauss, Laboratoire de Biologie Tumorale-Oncogénétique, F-67000 Strasbourg, France.
    Sevenet N; Laboratoire de Génétique Constitutionnelle et INSERM U916 VINCO, Institut Bergonié, CEDEX, F-33076 Bordeaux, France.
    Uhrhammer N; Biologie Clinique et Oncologique, Biologie Moléculaire-Centre Jean Perrin, F-63000 Clermont-Ferrand, France.
    Bonnet C; Institut de Cancérologie, 6 Avenue de Bourgogne, F-54519 Vandœuvre-lès-Nancy, France.
    Tilkin-Mariamé AF; Cancer Research Center of Toulouse (CRCT), Institut National de la Santé et de la Recherche Médicale (INSERM) UMR 1037, F-31000 Toulouse, France.
    Houdayer C; Inserm U1245, UNIROUEN, Normandie University, Normandy Centre for Genomic and Personalized Medicine, F-76183 Rouen, France.; Normandy Centre for Genomic and 41 Personalized Medicine, Department of Genetics, University Hospital, F-76183 Rouen, France.
    Moncoutier V; Department of Genetics, Institut Curie, F-75248 Paris, France.; Institut Curie, PSL Research University, F-75005 Paris, France.
    Andrieu C; Department of Genetics, Institut Curie, F-75248 Paris, France.; Institut Curie, PSL Research University, F-75005 Paris, France.
    French Covar Group Collaborators
    Bièche I; Department of Genetics, Institut Curie, F-75248 Paris, France.; Faculty of Pharmaceutical and Biological Sciences, University of Paris, F-75006 Paris, France.
    Stern MH; Department of Genetics, Institut Curie, F-75248 Paris, France.; Institut Curie, INSERM U830, DNA Repair and Uveal Melanoma (D.R.U.M.), PSL Research University, F-75005 Paris, France.
    Stoppa-Lyonnet D; Department of Genetics, Institut Curie, F-75248 Paris, France.; Institut Curie, INSERM U830, DNA Repair and Uveal Melanoma (D.R.U.M.), PSL Research University, F-75005 Paris, France.; Faculty of Medicine, University of Paris, F-75005 Paris, France.
    Lidereau R; Department of Genetics, Institut Curie, F-75248 Paris, France.; Institut Curie, PSL Research University, F-75005 Paris, France.
    Toulas C; Laboratoire d'Oncogénétique, Institut Claudius Regaud, IUCT-O, F-31059 Toulouse, France.
    Rouleau E; Department of Biology, Gustave Roussy, Université Paris-Saclay, F-94805 Villejuif, France.
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    Źródło:
    Cancers [Cancers (Basel)] 2021 Jun 25; Vol. 13 (13). Date of Electronic Publication: 2021 Jun 25.
    Typ publikacji:
    Journal Article
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Genetic Landscape of Male Breast Cancer.
    Autorzy:
    Campos FAB; Deparment of Medical Oncology, A.C.Camargo Cancer Center, Sao Paulo 01509-010, Brazil.
    Rouleau E; Department of Medical Biology and Pathology, Gustave Roussy, Cancer Genetics Laboratory, Gustave Roussy, 94805 Villejuif, France.
    Torrezan GT; Genomics and Molecular Biology Group, International Center of Research CIPE, A.C.Camargo Cancer Center, Sao Paulo 01509-010, Brazil.; National Institute of Science and Technology in Oncogenomics (INCITO), Sao Paulo 01508-010, Brazil.
    Carraro DM; Genomics and Molecular Biology Group, International Center of Research CIPE, A.C.Camargo Cancer Center, Sao Paulo 01509-010, Brazil.; National Institute of Science and Technology in Oncogenomics (INCITO), Sao Paulo 01508-010, Brazil.
    Casali da Rocha JC; Department of Oncogenetics, A.C.Camargo Cancer Center, Sao Paulo 01509-010, Brazil.
    Mantovani HK; Department of Obstetrics and Gynecology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas 13083-881, Brazil.
    da Silva LR; Department of Obstetrics and Gynecology, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Campinas 13083-881, Brazil.
    Osório CABT; Department of Pathology, A.C.Camargo Cancer Center, Sao Paulo 01509-010, Brazil.
    Moraes Sanches S; Deparment of Medical Oncology, A.C.Camargo Cancer Center, Sao Paulo 01509-010, Brazil.
    Caputo SM; Department of Genetics, Institut Curie, 75248 Paris, France.; Institut Curie, PSL Research University, 75005 Paris, France.
    Santana Dos Santos E; Deparment of Medical Oncology, A.C.Camargo Cancer Center, Sao Paulo 01509-010, Brazil.; Centro de Oncologia, Hospital Sírio Libanês, Sao Paulo 01308-050, Brazil.
    Pokaż więcej
    Źródło:
    Cancers [Cancers (Basel)] 2021 Jul 15; Vol. 13 (14). Date of Electronic Publication: 2021 Jul 15.
    Typ publikacji:
    Journal Article; Review
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Intrinsic Disorder and Phosphorylation in BRCA2 Facilitate Tight Regulation of Multiple Conserved Binding Events.
    Autorzy:
    Julien M; Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Université Paris-Sud, 91190 Gif-sur-Yvette, France.; L'Institut de Biologie Intégrative de la Cellule (I2BC), UMR 9198, Paris-Saclay University, 91190 Gif-sur-Yvette, France.
    Ghouil R; Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Université Paris-Sud, 91190 Gif-sur-Yvette, France.; L'Institut de Biologie Intégrative de la Cellule (I2BC), UMR 9198, Paris-Saclay University, 91190 Gif-sur-Yvette, France.
    Petitalot A; Service de Génétique, Unité de Génétique Constitutionnelle, Institut Curie, 75005 Paris, France.; Institut Curie, Paris Sciences Lettres Research University, 75005 Paris, France.
    Caputo SM; Service de Génétique, Unité de Génétique Constitutionnelle, Institut Curie, 75005 Paris, France.; Institut Curie, Paris Sciences Lettres Research University, 75005 Paris, France.
    Carreira A; L'Institut de Biologie Intégrative de la Cellule (I2BC), UMR 9198, Paris-Saclay University, 91190 Gif-sur-Yvette, France.; Institut Curie, Paris Sciences Lettres Research University, 75005 Paris, France.; Unité Intégrité du Génome, ARN et Cancer, Institut Curie, CNRS UMR3348, 91405 Orsay, France.
    Zinn-Justin S; Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Université Paris-Sud, 91190 Gif-sur-Yvette, France.; L'Institut de Biologie Intégrative de la Cellule (I2BC), UMR 9198, Paris-Saclay University, 91190 Gif-sur-Yvette, France.
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    Źródło:
    Biomolecules [Biomolecules] 2021 Jul 20; Vol. 11 (7). Date of Electronic Publication: 2021 Jul 20.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't; Review
    MeSH Terms:
    BRCA2 Protein/*chemistry
    BRCA2 Protein/*metabolism
    DNA Repair/*physiology
    BRCA2 Protein/genetics ; Binding Sites ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Cell Cycle Proteins/metabolism ; DNA Breaks, Double-Stranded ; Female ; Humans ; Interphase/physiology ; Magnetic Resonance Spectroscopy ; Mitosis ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/metabolism ; Phosphorylation ; Protein Serine-Threonine Kinases/metabolism ; Proto-Oncogene Proteins/metabolism ; Polo-Like Kinase 1
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    A new hybrid record linkage process to make epidemiological databases interoperable: application to the GEMO and GENEPSO studies involving BRCA1 and BRCA2 mutation carriers.
    Autorzy:
    Jiao Y; Department of Genetics, Institut Curie, PSL Research University, Paris, France.; Inserm, U900, Paris, France.; Institut Curie, PSL Research University, Mines ParisTech, Paris, France.
    Lesueur F; Inserm, U900, Paris, France.; Institut Curie, PSL Research University, Mines ParisTech, Paris, France.
    Azencott CA; Inserm, U900, Paris, France.; Mines ParisTech, PSL Research University, CBIO-Centre for Computational Biology, Paris, France.
    Laurent M; Department of Genetics, Institut Curie, PSL Research University, Paris, France.
    Mebirouk N; Inserm, U900, Paris, France.; Institut Curie, PSL Research University, Mines ParisTech, Paris, France.
    Laborde L; Institut Paoli-Calmettes, Centre de Traitement des Données IPC-PACA, Département de la Recherche Clinique et de l'Innovation, Marseille, France.
    Beauvallet J; Inserm, U900, Paris, France.; Institut Curie, PSL Research University, Mines ParisTech, Paris, France.
    Dondon MG; Inserm, U900, Paris, France.; Institut Curie, PSL Research University, Mines ParisTech, Paris, France.
    Eon-Marchais S; Inserm, U900, Paris, France.; Institut Curie, PSL Research University, Mines ParisTech, Paris, France.
    Laugé A; Department of Genetics, Institut Curie, PSL Research University, Paris, France.
    Noguès C; Institut Paoli-Calmettes, Département d'Anticipation et de Suivi du Cancer, Oncogénétique clinique, Marseille France Inserm, U830, Université Paris Descartes, Paris, France.; Aix Marseille Univ, INSERM, IRD, SESSTIM, Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale, Marseille, France.
    Andrieu N; Inserm, U900, Paris, France.; Institut Curie, PSL Research University, Mines ParisTech, Paris, France.
    Stoppa-Lyonnet D; Department of Genetics, Institut Curie, PSL Research University, Paris, France.; Paris University, Paris, France.; Inserm, U830, Paris, France.
    Caputo SM; Department of Genetics, Institut Curie, PSL Research University, Paris, France. sandrine.caputo@curie.fr.
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    Corporate Authors:
    GEMO Study Collaborators
    GENEPSO Study Collaborators
    Źródło:
    BMC medical research methodology [BMC Med Res Methodol] 2021 Jul 29; Vol. 21 (1), pp. 155. Date of Electronic Publication: 2021 Jul 29.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Breast Neoplasms*
    BRCA1 Protein/genetics ; BRCA2 Protein/genetics ; Cohort Studies ; Databases, Factual ; Female ; Genetic Predisposition to Disease ; Humans ; Mutation ; Prospective Studies ; Risk
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Combined Tumor-Based BRCA1/2 and TP53 Mutation Testing in Ovarian Cancer.
    Autorzy:
    Borcoman E; Department of Medical Oncology, Institut Curie, 75005 Paris, France.; Department of Drug Development and Innovation (D3i), Institut Curie, 75005 Paris, France.
    Santana Dos Santos E; Department of Medical Oncology, A.C.Camargo Cancer Center, São Paulo 01509-010, Brazil.
    Genestie C; Department of Medical Biology and Pathology, Gustave Roussy, 94805 Villejuif, France.; INSERM U981, Translational Research Laboratory, University Paris-Saclay, 94805 Villejuif, France.
    Pautier P; Gynecology Unit, Gustave Roussy, 94805 Villejuif, France.; Groupe d'Investigateurs Nationaux pour l'Etude des Cancers Ovariens (GINECO), 94805 Villejuif, France.
    Lacroix L; Department of Medical Biology and Pathology, Gustave Roussy, 94805 Villejuif, France.
    Caputo SM; Department of Genetics, Institut Curie, PSL Research University, 75005 Paris, France.
    Cabaret O; Department of Medical Biology and Pathology, Gustave Roussy, 94805 Villejuif, France.
    Guillaud-Bataille M; Department of Medical Biology and Pathology, Gustave Roussy, 94805 Villejuif, France.
    Michels J; Gynecology Unit, Gustave Roussy, 94805 Villejuif, France.
    Auguste A; INSERM U981, Translational Research Laboratory, University Paris-Saclay, 94805 Villejuif, France.
    Leary A; INSERM U981, Translational Research Laboratory, University Paris-Saclay, 94805 Villejuif, France.; Gynecology Unit, Gustave Roussy, 94805 Villejuif, France.
    Rouleau E; Department of Medical Biology and Pathology, Gustave Roussy, 94805 Villejuif, France.; INSERM U981, Translational Research Laboratory, University Paris-Saclay, 94805 Villejuif, France.
    Pokaż więcej
    Źródło:
    International journal of molecular sciences [Int J Mol Sci] 2023 Jul 18; Vol. 24 (14). Date of Electronic Publication: 2023 Jul 18.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    BRCA1 Protein*/genetics
    Ovarian Neoplasms*/diagnosis
    Ovarian Neoplasms*/genetics
    Ovarian Neoplasms*/pathology
    Humans ; Female ; BRCA2 Protein/genetics ; Mutation ; Germ-Line Mutation ; Tumor Suppressor Protein p53/genetics
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
      Wyświetlanie 1-8 z 8

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