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Wyszukujesz frazę ""Carbon Tetrachloride Poisoning"" wg kryterium: Temat


Tytuł :
Schisandrin B suppresses liver fibrosis in rats by targeting miR-101-5p through the TGF-β signaling pathway.
Autorzy :
Cuiqiong W; Key Laboratory Breeding Base of Hunan Oriented Fundamental and Applied Research of Innovative Pharmaceutics, Department of Basic Medical Science, Changsha Medical University, Changsha, China.
Chao X; Key Laboratory Breeding Base of Hunan Oriented Fundamental and Applied Research of Innovative Pharmaceutics, Department of Basic Medical Science, Changsha Medical University, Changsha, China.
Xinling F; Key Laboratory Breeding Base of Hunan Oriented Fundamental and Applied Research of Innovative Pharmaceutics, Department of Basic Medical Science, Changsha Medical University, Changsha, China.
Yinyan J; Key Laboratory Breeding Base of Hunan Oriented Fundamental and Applied Research of Innovative Pharmaceutics, Department of Basic Medical Science, Changsha Medical University, Changsha, China.
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Źródło :
Artificial cells, nanomedicine, and biotechnology [Artif Cells Nanomed Biotechnol] 2020 Dec; Vol. 48 (1), pp. 473-478.
Typ publikacji :
Journal Article; Video-Audio Media
MeSH Terms :
Carbon Tetrachloride Poisoning*/drug therapy
Carbon Tetrachloride Poisoning*/metabolism
Carbon Tetrachloride Poisoning*/pathology
Liver Cirrhosis*/chemically induced
Liver Cirrhosis*/drug therapy
Liver Cirrhosis*/metabolism
Liver Cirrhosis*/pathology
Lignans/*pharmacology
MicroRNAs/*metabolism
Polycyclic Compounds/*pharmacology
Signal Transduction/*drug effects
Transforming Growth Factor beta/*metabolism
Animals ; Cyclooctanes/pharmacology ; Humans ; Male ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Structural characterization of phosphorylated Pleurotus ostreatus polysaccharide and its hepatoprotective effect on carbon tetrachloride-induced liver injury in mice.
Autorzy :
Duan Z; College of Food Engineering and Nutrition Science, Shaanxi Normal University, Xi'an 710119, China.
Zhang Y; College of Food Engineering and Nutrition Science, Shaanxi Normal University, Xi'an 710119, China.
Zhu C; College of Food Engineering and Nutrition Science, Shaanxi Normal University, Xi'an 710119, China; International Joint Research Center of Shaanxi Province for Food and Health Sciences, Xi'an 710119, China. Electronic address: .
Wu Y; College of Food Engineering and Nutrition Science, Shaanxi Normal University, Xi'an 710119, China.
Du B; College of Food Engineering and Nutrition Science, Shaanxi Normal University, Xi'an 710119, China.
Ji H; College of Food Engineering and Nutrition Science, Shaanxi Normal University, Xi'an 710119, China.
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2020 Nov 01; Vol. 162, pp. 533-547. Date of Electronic Publication: 2020 Jun 18.
Typ publikacji :
Journal Article
MeSH Terms :
Fungal Polysaccharides*/chemistry
Fungal Polysaccharides*/isolation & purification
Fungal Polysaccharides*/pharmacology
Carbon Tetrachloride Poisoning/*drug therapy
Chemical and Drug Induced Liver Injury/*drug therapy
Pleurotus/*chemistry
Animals ; Carbon Tetrachloride Poisoning/metabolism ; Carbon Tetrachloride Poisoning/pathology ; Chemical and Drug Induced Liver Injury/metabolism ; Chemical and Drug Induced Liver Injury/pathology ; Male ; Mice ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Vildagliptin, a DPP-4 inhibitor, attenuates carbon tetrachloride-induced liver fibrosis by targeting ERK1/2, p38α, and NF-κB signaling.
Autorzy :
Khalil R; Department of Biochemistry, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, Egypt.
Shata A; Department of Clinical pharmacology, Faculty of Medicine, Mansoura University, Mansoura, Egypt; Department of Clinical Pharmacy, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, Egypt.
Abd El-Kader EM; Department of Pharmacology, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, Egypt.
Sharaf H; Department of Clinical Pharmacy, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, Egypt.
Abdo WS; Department of Pathology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt.
Amin NA; Department of Haematology, Theodor Bilharz Research Institute, Egypt.
Saber S; Department of Pharmacology, Faculty of Pharmacy, Delta University for Science and Technology, Gamasa, Egypt. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2020 Nov 15; Vol. 407, pp. 115246. Date of Electronic Publication: 2020 Sep 19.
Typ publikacji :
Journal Article
MeSH Terms :
Carbon Tetrachloride Poisoning/*drug therapy
Dipeptidyl-Peptidase IV Inhibitors/*pharmacology
Liver Cirrhosis/*drug therapy
Signal Transduction/*drug effects
Vildagliptin/*pharmacology
Animals ; Carbon Tetrachloride Poisoning/pathology ; Cell Survival/drug effects ; Dipeptidyl-Peptidase IV Inhibitors/administration & dosage ; Dipeptidyl-Peptidase IV Inhibitors/therapeutic use ; Dose-Response Relationship, Drug ; Inflammation Mediators/metabolism ; Liver Cirrhosis/chemically induced ; Liver Cirrhosis/pathology ; Liver Function Tests ; MAP Kinase Signaling System/drug effects ; Male ; Mice ; NF-kappa B/drug effects ; Phosphorylation ; Primary Cell Culture ; Rats ; Survival ; Vildagliptin/administration & dosage ; Vildagliptin/therapeutic use ; p38 Mitogen-Activated Protein Kinases/drug effects
Czasopismo naukowe
Tytuł :
Carbon tetrachloride poisoning from an antique fire extinguisher.
Autorzy :
Meaden CW; Rutgers New Jersey Medical School, Newark, NJ, United States of America; New Jersey Poison Information and Education System, Newark, NJ, United States of America. Electronic address: .
Procopio G; Hackensack University Medical Center, Hackensack, NJ, United States of America.
Calello DP; Rutgers New Jersey Medical School, Newark, NJ, United States of America; New Jersey Poison Information and Education System, Newark, NJ, United States of America.
Nelson LS; Rutgers New Jersey Medical School, Newark, NJ, United States of America; New Jersey Poison Information and Education System, Newark, NJ, United States of America.
Ruck B; Rutgers New Jersey Medical School, Newark, NJ, United States of America; New Jersey Poison Information and Education System, Newark, NJ, United States of America.
Gupta A; Hackensack University Medical Center, Hackensack, NJ, United States of America.
Jacob JE; Rutgers New Jersey Medical School, Newark, NJ, United States of America; New Jersey Poison Information and Education System, Newark, NJ, United States of America.
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Źródło :
The American journal of emergency medicine [Am J Emerg Med] 2020 Oct; Vol. 38 (10), pp. 2139-2141. Date of Electronic Publication: 2020 Jul 24.
Typ publikacji :
Case Reports; Historical Article; Journal Article
MeSH Terms :
Carbon Tetrachloride/*toxicity
Carbon Tetrachloride Poisoning/*complications
Adult ; Carbon Tetrachloride/adverse effects ; Carbon Tetrachloride/history ; Carbon Tetrachloride Poisoning/etiology ; Emergency Service, Hospital/organization & administration ; Fire Extinguishing Systems/history ; Hematemesis/etiology ; History, 20th Century ; Humans ; Liver/abnormalities ; Liver/drug effects ; Liver/physiopathology ; Male ; Vomiting/drug therapy ; Vomiting/etiology
Czasopismo naukowe
Tytuł :
Chronic Carbon Tetrachloride Applications Induced Hepatocyte Apoptosis in Lipocalin 2 Null Mice Through Endoplasmic Reticulum Stress and Unfolded Protein Response.
Autorzy :
Borkham-Kamphorst E; Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH Aachen University Hospital, D-52074 Aachen, Germany.
Haas U; Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH Aachen University Hospital, D-52074 Aachen, Germany.
Van de Leur E; Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH Aachen University Hospital, D-52074 Aachen, Germany.
Trevanich A; Department of Statistics, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
Weiskirchen R; Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, RWTH Aachen University Hospital, D-52074 Aachen, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Jul 23; Vol. 21 (15). Date of Electronic Publication: 2020 Jul 23.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*/drug effects
Apoptosis*/genetics
Endoplasmic Reticulum Stress*/drug effects
Endoplasmic Reticulum Stress*/genetics
Unfolded Protein Response*/drug effects
Unfolded Protein Response*/genetics
Carbon Tetrachloride/*toxicity
Carbon Tetrachloride Poisoning/*metabolism
Hepatocytes/*metabolism
Lipocalin-2/*deficiency
Animals ; Carbon Tetrachloride Poisoning/genetics ; Carbon Tetrachloride Poisoning/pathology ; Hepatocytes/pathology ; Lipocalin-2/metabolism ; Lipogenesis/drug effects ; Lipogenesis/genetics ; Mice ; Mice, Knockout ; Signal Transduction/drug effects ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
Hepatic stellate cell hypertrophy is associated with metabolic liver fibrosis.
Autorzy :
Hoffmann C; Université Paris Descartes, UTCBS, CNRS, INSERM, F-75006, Paris, France. .
Djerir NEH; Université Paris Descartes, UTCBS, CNRS, INSERM, F-75006, Paris, France.
Danckaert A; Institut Pasteur, C2RT, UTechS Photonic BioImaging, Paris, France.
Fernandes J; Institut Pasteur, C2RT, UTechS Photonic BioImaging, Paris, France.
Roux P; Institut Pasteur, C2RT, UTechS Photonic BioImaging, Paris, France.
Charrueau C; Université Paris Descartes, UTCBS, CNRS, INSERM, F-75006, Paris, France.
Lachagès AM; Université Paris Descartes, UTCBS, CNRS, INSERM, F-75006, Paris, France.
Charlotte F; Service d'Anatomie et Cytologie Pathologiques, Hôpitaux universitaires Pitié-Salpêtrière-Charles Foix (AP-HP), F-75013, Paris, France.
Brocheriou I; Service d'Anatomie et Cytologie Pathologiques, Hôpitaux universitaires Pitié-Salpêtrière-Charles Foix (AP-HP), F-75013, Paris, France.
Clément K; Sorbonne Université, Inserm, UMRS NutriOmique, Service de Nutrition, Hôpitaux universitaires Pitié-Salpêtrière-Charles Foix, F-75013, Paris, France.
Aron-Wisnewsky J; Sorbonne Université, Inserm, UMRS NutriOmique, Service de Nutrition, Hôpitaux universitaires Pitié-Salpêtrière-Charles Foix, F-75013, Paris, France.
Foufelle F; INSERM, Sorbonne Université, Université de Paris; Centre de Recherche des Cordeliers, F-75006, Paris, France.
Ratziu V; INSERM, Sorbonne Université, Université de Paris; Centre de Recherche des Cordeliers, F-75006, Paris, France.; Sorbonne Université, Institute for Cardiometabolism and Nutrition, Hôpital Pitié Salpêtrière, Assistance Publique Hôpitaux de Paris, Paris, France.
Hainque B; Université Paris Descartes, UTCBS, CNRS, INSERM, F-75006, Paris, France.; Service de Biochimie métabolique, Hôpitaux universitaires Pitié-Salpêtrière-Charles Foix (AP-HP), F-75013, Paris, France.
Bonnefont-Rousselot D; Université Paris Descartes, UTCBS, CNRS, INSERM, F-75006, Paris, France.; Service de Biochimie métabolique, Hôpitaux universitaires Pitié-Salpêtrière-Charles Foix (AP-HP), F-75013, Paris, France.
Bigey P; Université Paris Descartes, UTCBS, CNRS, INSERM, F-75006, Paris, France.; Chimie ParisTech, PSL Research University, UTCBS, F-75005, Paris, France.
Escriou V; Université Paris Descartes, UTCBS, CNRS, INSERM, F-75006, Paris, France.
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Źródło :
Scientific reports [Sci Rep] 2020 Mar 02; Vol. 10 (1), pp. 3850. Date of Electronic Publication: 2020 Mar 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carbon Tetrachloride Poisoning*/metabolism
Carbon Tetrachloride Poisoning*/pathology
Hepatic Stellate Cells*/metabolism
Hepatic Stellate Cells*/pathology
Liver Cirrhosis*/chemically induced
Liver Cirrhosis*/metabolism
Liver Cirrhosis*/pathology
Dietary Fats/*adverse effects
Animals ; Dietary Fats/pharmacology ; Humans ; Male ; Mice
Czasopismo naukowe
Tytuł :
Hepatoprotective effect of linagliptin against liver fibrosis induced by carbon tetrachloride in mice.
Autorzy :
Abd Elmaaboud M; Department of Pharmacology, Faculty of Medicine, Tanta University, Tanta, Egypt.
Khattab H; Department of Physiology, Faculty of Medicine, Tanta University, Tanta, Egypt.
Shalaby S; Department of Pharmacology, Faculty of Medicine, Tanta University, Tanta, Egypt.
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Źródło :
Canadian journal of physiology and pharmacology [Can J Physiol Pharmacol] 2021 Mar; Vol. 99 (3), pp. 294-302. Date of Electronic Publication: 2020 Jul 29.
Typ publikacji :
Journal Article
MeSH Terms :
Carbon Tetrachloride Poisoning/*prevention & control
Chemical and Drug Induced Liver Injury/*prevention & control
Hypoglycemic Agents/*therapeutic use
Linagliptin/*therapeutic use
Liver Cirrhosis/*chemically induced
Liver Cirrhosis/*prevention & control
Alanine Transaminase/blood ; Animals ; Aspartate Aminotransferases/blood ; Liver Function Tests ; Male ; Mice ; Mice, Inbred BALB C ; Oxidative Stress/drug effects ; TOR Serine-Threonine Kinases/antagonists & inhibitors ; TOR Serine-Threonine Kinases/biosynthesis ; Transforming Growth Factor beta1/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
Connective tissue growth factor in hepatocytes is elevated by carbon tetrachloride via STAT3 activation.
Autorzy :
Chen W; Department of Internal Medicine, E‑Da Hospital, I‑Shou University, Kaohsiung 82401, Taiwan, R.O.C.
Li Y; Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890‑8520, Japan.
Hsu CT; Department of Pathology, E‑Da Hospital, I‑Shou University, Kaohsiung 82401, Taiwan, R.O.C.
Niu CS; Department of Nursing, Tzu Chi University of Science and Technology, Hualien 97005, Taiwan, R.O.C.
Pen WH; Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan, R.O.C.
Cheng KC; Pharmacological Department of Herbal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890‑8520, Japan.
Niu HS; Department of Nursing, Tzu Chi University of Science and Technology, Hualien 97005, Taiwan, R.O.C.
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Źródło :
Molecular medicine reports [Mol Med Rep] 2020 Mar; Vol. 21 (3), pp. 1390-1398. Date of Electronic Publication: 2020 Jan 08.
Typ publikacji :
Journal Article
MeSH Terms :
Carbon Tetrachloride/*toxicity
Carbon Tetrachloride Poisoning/*metabolism
Connective Tissue Growth Factor/*metabolism
Hepatocytes/*metabolism
Liver Cirrhosis/*metabolism
STAT3 Transcription Factor/*metabolism
Animals ; Carbon Tetrachloride Poisoning/pathology ; Cell Line ; Hepatocytes/pathology ; Liver Cirrhosis/chemically induced ; Liver Cirrhosis/pathology ; Male ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Assessment of the hepatoprotective effect of developed lipid-polymer hybrid nanoparticles (LPHNPs) encapsulating naturally extracted β-Sitosterol against CCl 4 induced hepatotoxicity in rats.
Autorzy :
Abdou EM; Department of Pharmaceutics, National organization of Drug control and Research (NODCAR), Giza, Egypt. .; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, MTI University, Cairo, Egypt. .
Fayed MAA; Department of Pharmacognosy, Faculty of Pharmacy, University of Sadat City, Sadat City, Egypt.
Helal D; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, El-Fayoum University, El-Fayoum, Egypt.
Ahmed KA; Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt.
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Źródło :
Scientific reports [Sci Rep] 2019 Dec 24; Vol. 9 (1), pp. 19779. Date of Electronic Publication: 2019 Dec 24.
Typ publikacji :
Journal Article
MeSH Terms :
Antioxidants*/chemistry
Antioxidants*/pharmacology
Carbon Tetrachloride Poisoning*/drug therapy
Carbon Tetrachloride Poisoning*/metabolism
Carbon Tetrachloride Poisoning*/pathology
Nanoparticles*/chemistry
Sitosterols*/chemistry
Sitosterols*/pharmacology
Liver/*metabolism
Animals ; Centaurea/chemistry ; Lipids/chemistry ; Lipids/pharmacology ; Liver/pathology ; Male ; Polyesters/chemistry ; Polyesters/pharmacology ; Polyethylene Glycols/chemistry ; Polyethylene Glycols/pharmacology ; Rats
Czasopismo naukowe
Tytuł :
Co-administration of resveratrol and beta-aminopropionitrile attenuates liver fibrosis development via targeting lysyl oxidase in CCl 4 -induced liver fibrosis in rats.
Autorzy :
Mohseni R; Department of Clinical Biochemistry, Hamadan University of Medical Sciences, Hamadan, Iran.
Arab Sadeghabadi Z; Department of Clinical Biochemistry, Hamadan University of Medical Sciences, Hamadan, Iran.
Goodarzi MT; Department of Biochemistry, Islamic Azad University, Shahrood Branch, Shahrood, Iran.
Karimi J; Department of Clinical Biochemistry, Hamadan University of Medical Sciences, Hamadan, Iran.; Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
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Źródło :
Immunopharmacology and immunotoxicology [Immunopharmacol Immunotoxicol] 2019 Dec; Vol. 41 (6), pp. 644-651. Date of Electronic Publication: 2019 Nov 14.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Delivery Systems*
Aminopropionitrile/*pharmacology
Carbon Tetrachloride Poisoning/*drug therapy
Liver Cirrhosis/*drug therapy
Protein-Lysine 6-Oxidase/*immunology
Resveratrol/*pharmacology
Animals ; Carbon Tetrachloride Poisoning/immunology ; Carbon Tetrachloride Poisoning/pathology ; Liver Cirrhosis/chemically induced ; Liver Cirrhosis/immunology ; Liver Cirrhosis/pathology ; Male ; Rats ; Rats, Wistar
Czasopismo naukowe
Tytuł :
TIM-4 interference in Kupffer cells against CCL4-induced liver fibrosis by mediating Akt1/Mitophagy signalling pathway.
Autorzy :
Wu H; Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Chen G; Department of Hepatobiliary and pancreatic surgery, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, China.
Wang J; Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Deng M; Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yuan F; Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Gong J; Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
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Źródło :
Cell proliferation [Cell Prolif] 2020 Jan; Vol. 53 (1), pp. e12731. Date of Electronic Publication: 2019 Nov 22.
Typ publikacji :
Journal Article
MeSH Terms :
Carbon Tetrachloride Poisoning/*metabolism
Kupffer Cells/*metabolism
Liver Cirrhosis/*metabolism
Membrane Proteins/*metabolism
Mitophagy/*drug effects
Proto-Oncogene Proteins c-akt/*metabolism
Signal Transduction/*drug effects
Animals ; Carbon Tetrachloride/toxicity ; Carbon Tetrachloride Poisoning/pathology ; Disease Models, Animal ; Kupffer Cells/pathology ; Liver Cirrhosis/chemically induced ; Liver Cirrhosis/pathology ; Male ; Mice
Czasopismo naukowe
Tytuł :
THE EFFECTS OF L-ORNITINE AND L-ARGININE ON THE PROCESSES OF LIPID PEROXIDATION IN THE FUNCTIONAL LAYERS OF KIDNEYS ON THE BACKGROUND OF ACUTE TOXIC HEPATITIS.
Autorzy :
Krekhovska-Lepiavko OM; I. HORBACHEVSKY TERNOPIL NATIONAL MEDICAL UNIVERSITY OF THE MINISTRY OF HEALTH OF UKRAINE, TERNOPIL, UKRAINE.
Lokay BA; I. HORBACHEVSKY TERNOPIL NATIONAL MEDICAL UNIVERSITY OF THE MINISTRY OF HEALTH OF UKRAINE, TERNOPIL, UKRAINE.
Hudyma AA; I. HORBACHEVSKY TERNOPIL NATIONAL MEDICAL UNIVERSITY OF THE MINISTRY OF HEALTH OF UKRAINE, TERNOPIL, UKRAINE.
Yastremska SO; I. HORBACHEVSKY TERNOPIL NATIONAL MEDICAL UNIVERSITY OF THE MINISTRY OF HEALTH OF UKRAINE, TERNOPIL, UKRAINE.
Yurchyshyn OM; I. HORBACHEVSKY TERNOPIL NATIONAL MEDICAL UNIVERSITY OF THE MINISTRY OF HEALTH OF UKRAINE, TERNOPIL, UKRAINE.
Mazur LP; I. HORBACHEVSKY TERNOPIL NATIONAL MEDICAL UNIVERSITY OF THE MINISTRY OF HEALTH OF UKRAINE, TERNOPIL, UKRAINE.
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Źródło :
Wiadomosci lekarskie (Warsaw, Poland : 1960) [Wiad Lek] 2020; Vol. 73 (11), pp. 2498-2502.
Typ publikacji :
Journal Article
MeSH Terms :
Carbon Tetrachloride Poisoning*/metabolism
Chemical and Drug Induced Liver Injury*/drug therapy
Chemical and Drug Induced Liver Injury*/etiology
Chemical and Drug Induced Liver Injury*/metabolism
Animals ; Arginine/metabolism ; Kidney ; Lipid Peroxidation ; Liver/metabolism ; Male ; Rats
Czasopismo naukowe
Tytuł :
Saturated hydrogen alleviates CCl 4 -induced acute kidney injury via JAK2/STAT3/p65 signaling.
Autorzy :
Wu S; Emergency Department, The Third Affiliated Hospital of Soochow University, The First People's Hospital of Changzhou, Changzhou, Jiangsu, China.
Fang Z; Emergency Department, The Third Affiliated Hospital of Soochow University, The First People's Hospital of Changzhou, Changzhou, Jiangsu, China.
Zhou S; Department of Critical Care Medicine, The Third Affiliated Hospital of Soochow University, The First People's Hospital of Changzhou, Changzhou, Jiangsu, China.
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Źródło :
The Journal of international medical research [J Int Med Res] 2020 Jan; Vol. 48 (1), pp. 300060519895353.
Typ publikacji :
Journal Article
MeSH Terms :
Signal Transduction*
Acute Kidney Injury/*chemically induced
Acute Kidney Injury/*therapy
Carbon Tetrachloride Poisoning/*metabolism
Janus Kinase 2/*metabolism
STAT3 Transcription Factor/*metabolism
Transcription Factor RelA/*metabolism
Acute Kidney Injury/enzymology ; Acute Kidney Injury/metabolism ; Animals ; Carbon Tetrachloride Poisoning/complications ; Disease Models, Animal ; Hydrogen/metabolism ; Inflammation Mediators/antagonists & inhibitors ; Inflammation Mediators/metabolism ; Male ; Malondialdehyde/metabolism ; Mice ; Oxidative Stress
Czasopismo naukowe
Tytuł :
Use of combined nanocarrier system based on chitosan nanoparticles and phospholipids complex for improved delivery of ferulic acid.
Autorzy :
Telange DR; Rajarshi Shahu College of Pharmacy, Malvihir, Botha Road, Buldhana 443301, M.S., India. Electronic address: .
Jain SP; Rajarshi Shahu College of Pharmacy, Malvihir, Botha Road, Buldhana 443301, M.S., India.
Pethe AM; School of Pharmacy and Technology Management, SVKM's NMIMS (Deemed to be University), Pollepally SEZ, Jadcherla, Mehbubnagar, Hyderabad 509301, India.
Kharkar PS; Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai 400019, M.S., India.
Rarokar NR; Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University, Nagpur, 440033, M.S., India.
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Feb 28; Vol. 171, pp. 288-307. Date of Electronic Publication: 2021 Jan 05.
Typ publikacji :
Journal Article
MeSH Terms :
Antioxidants/*chemistry
Chitosan/*chemistry
Coumaric Acids/*administration & dosage
Drug Carriers/*chemistry
Nanoparticles/*chemistry
Phospholipids/*chemistry
Administration, Oral ; Animals ; Antioxidants/administration & dosage ; Antioxidants/pharmacokinetics ; Biological Availability ; Carbon Tetrachloride Poisoning/drug therapy ; Chemistry Techniques, Analytical ; Chitosan/administration & dosage ; Chitosan/pharmacokinetics ; Coumaric Acids/pharmacokinetics ; Delayed-Action Preparations ; Drug Carriers/administration & dosage ; Drug Carriers/pharmacokinetics ; Female ; Intestinal Absorption ; Liver/drug effects ; Liver/enzymology ; Male ; Microscopy, Electron, Scanning ; Models, Chemical ; Nanoparticles/administration & dosage ; Particle Size ; Phospholipids/administration & dosage ; Phospholipids/pharmacokinetics ; Rats ; Rats, Wistar ; Solubility ; Static Electricity
Czasopismo naukowe
Tytuł :
Network Pharmacology Study of the Hepatoprotective Effects of Quercetin-Containing Traditional Chinese Medicine, Anoectochilus roxburghii, and Validation of Quercetin as an Anti-Liver Injury Agent in a Mouse Model of Liver Injury.
Autorzy :
Lin W; FAFU and UIUC-SIB Joint Center for Genomics and Biotechnology, Fujian Agriculture and Forestry University, Fuzhou, Fujian, China (mainland).; Key Laboratory of National Forestry and Grassland Administration for Orchid Conservation and Utilization, Fujian Agriculture and Forestry University, Fuzhou, Fujian, China (mainland).
Wu Y; College of Horticulture, Fujian Agriculture and Forestry University, Fuzhou, Fujian, China (mainland).
Wang J; College of Horticulture, Fujian Agriculture and Forestry University, Fuzhou, Fujian, China (mainland).
Lin H; Key Laboratory of National Forestry and Grassland Administration for Orchid Conservation and Utilization, Fujian Agriculture and Forestry University, Fuzhou, Fujian, China (mainland).
Xu X; FAFU and UIUC-SIB Joint Center for Genomics and Biotechnology, Fujian Agriculture and Forestry University, Fuzhou, Fujian, China (mainland).
He G; College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou, Fujian, China (mainland).
He B; Key Laboratory of National Forestry and Grassland Administration for Orchid Conservation and Utilization, Fujian Agriculture and Forestry University, Fuzhou, Fujian, China (mainland).; College of Horticulture, Fujian Agriculture and Forestry University, Fuzhou, Fujian, China (mainland).
Ma X; FAFU and UIUC-SIB Joint Center for Genomics and Biotechnology, Fujian Agriculture and Forestry University, Fuzhou, Fujian, China (mainland).; Key Laboratory of National Forestry and Grassland Administration for Orchid Conservation and Utilization, Fujian Agriculture and Forestry University, Fuzhou, Fujian, China (mainland).
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Źródło :
Medical science monitor : international medical journal of experimental and clinical research [Med Sci Monit] 2020 Dec 16; Vol. 26, pp. e923533. Date of Electronic Publication: 2020 Dec 16.
Typ publikacji :
Journal Article
MeSH Terms :
Chemical and Drug Induced Liver Injury*/drug therapy
Chemical and Drug Induced Liver Injury*/prevention & control
Orchidaceae*
Quercetin/*pharmacology
Animals ; Antioxidants/pharmacology ; Carbon Tetrachloride Poisoning ; Disease Models, Animal ; Drug Evaluation ; Drugs, Chinese Herbal/pharmacology ; Medicine, Chinese Traditional ; Mice ; Protective Agents/pharmacology ; Protein Interaction Maps
Czasopismo naukowe
Tytuł :
Therapeutic effects of a small molecule agonist of the relaxin receptor ML290 in liver fibrosis.
Autorzy :
Kaftanovskaya EM; Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, USA.
Ng HH; Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, USA.
Soula M; Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, USA.
Rivas B; Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, USA.
Myhr C; Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, USA.
Ho BA; Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, USA.
Cervantes BA; Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, USA.
Shupe TD; Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Devarasetty M; Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Hu X; NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, USA.
Xu X; NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, USA.
Patnaik S; NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, USA.
Wilson KJ; NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, USA.
Barnaeva E; NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, USA.
Ferrer M; NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, USA.
Southall NT; NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, USA.
Marugan JJ; NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, USA.
Bishop CE; Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Agoulnik IU; Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, USA.
Agoulnik AI; Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, USA.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2019 Nov; Vol. 33 (11), pp. 12435-12446. Date of Electronic Publication: 2019 Aug 16.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Carbon Tetrachloride Poisoning/*drug therapy
Cell Proliferation/*drug effects
Liver Cirrhosis/*drug therapy
Receptors, G-Protein-Coupled/*antagonists & inhibitors
Receptors, Peptide/*antagonists & inhibitors
Signal Transduction/*drug effects
Animals ; Carbon Tetrachloride Poisoning/genetics ; Cell Line, Transformed ; Cell Proliferation/genetics ; Cytokines/genetics ; Cytokines/metabolism ; Humans ; Liver Cirrhosis/chemically induced ; Liver Cirrhosis/genetics ; Liver Cirrhosis/metabolism ; Mice ; Mice, Transgenic ; Organoids/metabolism ; Organoids/pathology ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism ; Receptors, Peptide/genetics ; Receptors, Peptide/metabolism ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
Attenuated fibrosis in specific pathogen-free microbiota in experimental cholestasis- and toxin-induced liver injury.
Autorzy :
Moghadamrad S; Department of Biomedical Research, Hepatology, University of Berne, Berne, Switzerland.; Clinic of Visceral Surgery and Medicine, Inselspital, Berne, Switzerland.
Hassan M; Department of Biomedical Research, Hepatology, University of Berne, Berne, Switzerland.
McCoy KD; Department of Biomedical Research, Gastroenterology, University of Berne, Berne, Switzerland.; Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Kirundi J; Department of Biomedical Research, Gastroenterology, University of Berne, Berne, Switzerland.
Kellmann P; Department of Biomedical Research, Hepatology, University of Berne, Berne, Switzerland.
De Gottardi A; Department of Biomedical Research, Hepatology, University of Berne, Berne, Switzerland.; Clinic of Visceral Surgery and Medicine, Inselspital, Berne, Switzerland.
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Źródło :
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2019 Nov; Vol. 33 (11), pp. 12464-12476. Date of Electronic Publication: 2019 Aug 20.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Microbiota*
Carbon Tetrachloride Poisoning/*microbiology
Chemical and Drug Induced Liver Injury/*microbiology
Cholestasis/*microbiology
Hypertension, Portal/*microbiology
Liver Cirrhosis/*microbiology
Animals ; Carbon Tetrachloride Poisoning/pathology ; Chemical and Drug Induced Liver Injury/pathology ; Cholestasis/chemically induced ; Cholestasis/pathology ; Hypertension, Portal/pathology ; Liver Cirrhosis/chemically induced ; Liver Cirrhosis/pathology ; Male ; Mice
Czasopismo naukowe
Tytuł :
Oct4 and Hnf4α-induced hepatic stem cells ameliorate chronic liver injury in liver fibrosis model.
Autorzy :
Park MR; Hans Schöler Stem Cell Research Center (HSSCRC), School of Life Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan, South Korea.
Wong MS; Hans Schöler Stem Cell Research Center (HSSCRC), School of Life Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan, South Korea.
Araúzo-Bravo MJ; Group of Computational Biology and Bioinformatics, Biodonostia Health Research Institute, San Sebastián, and IKERBASQUE, Basque Foundation for Science, Bilbao, Spain.
Lee H; Hans Schöler Stem Cell Research Center (HSSCRC), School of Life Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan, South Korea.
Nam D; Hans Schöler Stem Cell Research Center (HSSCRC), School of Life Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan, South Korea.
Park SY; Hans Schöler Stem Cell Research Center (HSSCRC), School of Life Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan, South Korea.
Seo HD; Hans Schöler Stem Cell Research Center (HSSCRC), School of Life Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan, South Korea.
Lee SM; Hans Schöler Stem Cell Research Center (HSSCRC), School of Life Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan, South Korea.
Zeilhofer HF; Department of Cranio-Maxillofacial Surgery, University Hospital Basel, Basel, Switzerland.
Zaehres H; Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Münster, Germany.
Schöler HR; Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Münster, Germany.
Kim JB; Hans Schöler Stem Cell Research Center (HSSCRC), School of Life Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan, South Korea.
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Źródło :
PloS one [PLoS One] 2019 Aug 12; Vol. 14 (8), pp. e0221085. Date of Electronic Publication: 2019 Aug 12 (Print Publication: 2019).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carbon Tetrachloride Poisoning*/genetics
Carbon Tetrachloride Poisoning*/metabolism
Carbon Tetrachloride Poisoning*/therapy
Hepatocyte Nuclear Factor 4*/genetics
Hepatocyte Nuclear Factor 4*/metabolism
Induced Pluripotent Stem Cells*/metabolism
Induced Pluripotent Stem Cells*/pathology
Induced Pluripotent Stem Cells*/transplantation
Liver*/metabolism
Liver*/pathology
Liver Cirrhosis*/chemically induced
Liver Cirrhosis*/genetics
Liver Cirrhosis*/metabolism
Liver Cirrhosis*/therapy
Lung Injury*/chemically induced
Lung Injury*/genetics
Lung Injury*/metabolism
Octamer Transcription Factor-3*/genetics
Octamer Transcription Factor-3*/metabolism
Stem Cell Transplantation*
Animals ; Male ; Mice
Czasopismo naukowe
Tytuł :
Diallyl sulfide ameliorates carbon tetrachloride-induced hepatotoxicity in rats via suppressing stress-activated MAPK signaling pathways.
Autorzy :
Elkhoely A; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Helwan University, Egypt.
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Źródło :
Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2019 Jun; Vol. 33 (6), pp. e22307. Date of Electronic Publication: 2019 Feb 27.
Typ publikacji :
Journal Article
MeSH Terms :
Carbon Tetrachloride Poisoning*/metabolism
Carbon Tetrachloride Poisoning*/pathology
Carbon Tetrachloride Poisoning*/prevention & control
Liver*/injuries
Liver*/metabolism
Liver*/pathology
Allyl Compounds/*pharmacology
Carbon Tetrachloride/*toxicity
MAP Kinase Signaling System/*drug effects
Sulfides/*pharmacology
Animals ; Cytokines/metabolism ; Heme Oxygenase (Decyclizing)/metabolism ; NF-E2-Related Factor 2/metabolism ; NF-kappa B/metabolism ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Inhibition of activated factor X; a new pathway in ameliorating carbon tetrachloride-induced liver fibrosis in rats.
Autorzy :
Mahmoud NI; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Nahda University, Beni-Suef, Egypt.
Messiha BAS; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.
Abo-Saif AA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Nahda University, Beni-Suef, Egypt.; Department of Pharmacology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Abdel-Bakky MS; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Nahda University, Beni-Suef, Egypt.; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.
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Źródło :
Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2019 May; Vol. 33 (5), pp. e22287. Date of Electronic Publication: 2019 Feb 04.
Typ publikacji :
Journal Article
MeSH Terms :
Carbon Tetrachloride Poisoning/*metabolism
Factor Xa/*metabolism
Factor Xa Inhibitors/*pharmacology
Liver Cirrhosis/*metabolism
Rivaroxaban/*pharmacology
Animals ; Carbon Tetrachloride/toxicity ; Carbon Tetrachloride Poisoning/pathology ; Carbon Tetrachloride Poisoning/prevention & control ; Factor Xa/pharmacology ; Liver Cirrhosis/chemically induced ; Liver Cirrhosis/pathology ; Liver Cirrhosis/prevention & control ; Male ; Rats ; Rats, Wistar
Czasopismo naukowe

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