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Wyszukujesz frazę ""Carbonic Anhydrase IX"" wg kryterium: Temat


Tytuł :
PET imaging and pharmacological therapy targeting carbonic anhydrase-IX high-expressing tumors using US2 platform based on bivalent ureidosulfonamide.
Autorzy :
Iikuni S; Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
Watanabe H; Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
Shimizu Y; Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.; Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Nakamoto Y; Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Ono M; Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
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Źródło :
PloS one [PLoS One] 2020 Dec 09; Vol. 15 (12), pp. e0243327. Date of Electronic Publication: 2020 Dec 09 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antigens, Neoplasm*/metabolism
Carbonic Anhydrase IX*/antagonists & inhibitors
Carbonic Anhydrase IX*/metabolism
Carbonic Anhydrase Inhibitors*/chemistry
Carbonic Anhydrase Inhibitors*/pharmacokinetics
Carbonic Anhydrase Inhibitors*/pharmacology
Neoplasm Proteins*/antagonists & inhibitors
Neoplasm Proteins*/metabolism
Neoplasms, Experimental*/diagnostic imaging
Neoplasms, Experimental*/drug therapy
Neoplasms, Experimental*/enzymology
Positron-Emission Tomography*
Yttrium Radioisotopes*/chemistry
Yttrium Radioisotopes*/pharmacokinetics
Yttrium Radioisotopes*/pharmacology
Animals ; HT29 Cells ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
A potentiated cooperation of carbonic anhydrase IX and histone deacetylase inhibitors against cancer.
Autorzy :
Ruzzolini J; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Florence, Italy.
Laurenzana A; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Florence, Italy.
Andreucci E; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Florence, Italy.
Peppicelli S; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Florence, Italy.
Bianchini F; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Florence, Italy.
Carta F; Department of NEUROFARBA, University of Florence, Florence, Italy.
Supuran CT; Department of NEUROFARBA, University of Florence, Florence, Italy.
Romanelli MN; Department of NEUROFARBA, University of Florence, Florence, Italy.
Nediani C; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Florence, Italy.
Calorini L; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Florence, Italy.; Center of Excellence for Research, Transfer and High Education, DenoTHE University of Florence, Florence, Italy.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 391-397.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Carbonic Anhydrase IX/*antagonists & inhibitors
Carbonic Anhydrase Inhibitors/*pharmacology
Histone Deacetylase Inhibitors/*pharmacology
Histone Deacetylases/*metabolism
Phenylurea Compounds/*pharmacology
Sulfonamides/*pharmacology
Antigens, Neoplasm/metabolism ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Carbonic Anhydrase IX/metabolism ; Carbonic Anhydrase Inhibitors/chemical synthesis ; Carbonic Anhydrase Inhibitors/chemistry ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Histone Deacetylase Inhibitors/chemical synthesis ; Histone Deacetylase Inhibitors/chemistry ; Humans ; Molecular Structure ; Phenylurea Compounds/chemical synthesis ; Phenylurea Compounds/chemistry ; Structure-Activity Relationship ; Sulfonamides/chemical synthesis ; Sulfonamides/chemistry ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Carbonic anhydrase IX as a novel candidate in liquid biopsy.
Autorzy :
Ozensoy Guler O; Department of Medical Biology, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey.
Supuran CT; Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Polo Scientifico, Firenze, Italy.
Capasso C; Department of Biology, Agriculture and Food Sciences, Institute of Biosciences and Bioresources, CNR, Napoli, Italy.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 255-260.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Biomarkers, Tumor/*antagonists & inhibitors
Carbonic Anhydrase IX/*antagonists & inhibitors
Carbonic Anhydrase Inhibitors/*pharmacology
Neoplasms/*diagnosis
Animals ; Biomarkers, Tumor/metabolism ; Carbonic Anhydrase IX/metabolism ; Carbonic Anhydrase Inhibitors/chemistry ; Humans ; Liquid Biopsy ; Neoplasms/enzymology
Czasopismo naukowe
Tytuł :
Plasmatic exosomes from prostate cancer patients show increased carbonic anhydrase IX expression and activity and low pH.
Autorzy :
Logozzi M; Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.
Mizzoni D; Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.
Capasso C; National Research Council, Institute of Biosciences and BioResources, Naples, Italy.
Del Prete S; National Research Council, Institute of Biosciences and BioResources, Naples, Italy.
Di Raimo R; Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.
Falchi M; National AIDS Center, Istituto Superiore di Sanità, Rome, Italy.
Angelini DF; Neuroimmunology Unit, IRCCS Santa Lucia Foundation, Rome, Italy.
Sciarra A; Department of Urology, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
Maggi M; Department of Urology, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
Supuran CT; NEUROFARBA Department, University of Florence, Section of Pharmaceutical Chemistry, Florence, Italy.
Fais S; Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 280-288.
Typ publikacji :
Journal Article
MeSH Terms :
Antigens, Neoplasm/*biosynthesis
Carbonic Anhydrase IX/*biosynthesis
Exosomes/*metabolism
Prostatic Neoplasms/*blood
Aged ; Antigens, Neoplasm/blood ; Carbonic Anhydrase IX/blood ; Cell Line ; Humans ; Hydrogen-Ion Concentration ; Male ; Microscopy, Confocal ; Middle Aged
Czasopismo naukowe
Tytuł :
Structural Basis of Nanomolar Inhibition of Tumor-Associated Carbonic Anhydrase IX: X-Ray Crystallographic and Inhibition Study of Lipophilic Inhibitors with Acetazolamide Backbone.
Autorzy :
Andring JT; Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, Florida 32610, United States.
Fouch M; Department of Pharmaceutical Sciences and Moulder Center for Drug Discovery Research, Temple University School of Pharmacy, 3307 N Broad Street, Philadelphia, Pennsylvania 19140, United States.
Akocak S; Department of Pharmaceutical Sciences and Moulder Center for Drug Discovery Research, Temple University School of Pharmacy, 3307 N Broad Street, Philadelphia, Pennsylvania 19140, United States.
Angeli A; NEUROFARBA Department, Pharmaceutical Sciences Section, Universita degli Studi di Firenze, Polo Scientifico, Via Ugo Schiff no. 6, 50019 Sesto Fiorentino, Florence, Italy.
Supuran CT; NEUROFARBA Department, Pharmaceutical Sciences Section, Universita degli Studi di Firenze, Polo Scientifico, Via Ugo Schiff no. 6, 50019 Sesto Fiorentino, Florence, Italy.
Ilies MA; Department of Pharmaceutical Sciences and Moulder Center for Drug Discovery Research, Temple University School of Pharmacy, 3307 N Broad Street, Philadelphia, Pennsylvania 19140, United States.
McKenna R; Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, Florida 32610, United States.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Nov 12; Vol. 63 (21), pp. 13064-13075. Date of Electronic Publication: 2020 Oct 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Acetazolamide/*chemistry
Carbonic Anhydrase IX/*metabolism
Carbonic Anhydrase Inhibitors/*chemistry
Acetazolamide/metabolism ; Binding Sites ; Carbonic Anhydrase IX/antagonists & inhibitors ; Carbonic Anhydrase IX/genetics ; Carbonic Anhydrase Inhibitors/metabolism ; Catalytic Domain ; Crystallography, X-Ray ; Humans ; Hydrophobic and Hydrophilic Interactions ; Isoenzymes/antagonists & inhibitors ; Isoenzymes/genetics ; Isoenzymes/metabolism ; Molecular Dynamics Simulation ; Neoplasms/enzymology ; Neoplasms/pathology ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/chemistry ; Recombinant Proteins/isolation & purification ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Sulfocoumarins as dual inhibitors of human carbonic anhydrase isoforms IX/XII and of human thioredoxin reductase.
Autorzy :
Krasavin M; Department of Chemistry, Saint Petersburg State University, Saint Petersburg, Russian Federation.
Žalubovskis R; Latvian Institute of Organic Synthesis, Riga, Latvia.; Faculty of Materials Science and Applied Chemistry, Institute of Technology of Organic Chemistry, Riga Technical University, Riga, Latvia.
Grandāne A; Latvian Institute of Organic Synthesis, Riga, Latvia.
Domračeva I; Latvian Institute of Organic Synthesis, Riga, Latvia.
Zhmurov P; Department of Chemistry, Saint Petersburg State University, Saint Petersburg, Russian Federation.
Supuran CT; Neurofarba Department, Universita degli Studi di Firenze, Florence, Italy.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 506-510.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Carbonic Anhydrase IX/*antagonists & inhibitors
Carbonic Anhydrases/*metabolism
Coumarins/*pharmacology
Enzyme Inhibitors/*pharmacology
Thioredoxin-Disulfide Reductase/*antagonists & inhibitors
Antigens, Neoplasm/metabolism ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Carbonic Anhydrase IX/metabolism ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Coumarins/chemical synthesis ; Coumarins/chemistry ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Humans ; Isoenzymes/antagonists & inhibitors ; Isoenzymes/metabolism ; MCF-7 Cells ; Molecular Structure ; Structure-Activity Relationship ; Thioredoxin-Disulfide Reductase/metabolism ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
7-Acylamino-3H-1,2-benzoxathiepine 2,2-dioxides as new isoform-selective carbonic anhydrase IX and XII inhibitors.
Autorzy :
Pustenko A; Latvian Institute of Organic Synthesis, Riga, Latvia.; Institute of Technology of Organic Chemistry, Faculty of Materials Science and Applied Chemistry, Riga Technical University, Riga, Latvia.
Nocentini A; Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Florence, Italy.
Balašova A; Latvian Institute of Organic Synthesis, Riga, Latvia.
Krasavin M; Department of Chemistry, Saint Petersburg State University, Saint Petersburg, Russian Federation.
Žalubovskis R; Latvian Institute of Organic Synthesis, Riga, Latvia.; Institute of Technology of Organic Chemistry, Faculty of Materials Science and Applied Chemistry, Riga Technical University, Riga, Latvia.
Supuran CT; Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Florence, Italy.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 650-656.
Typ publikacji :
Journal Article
MeSH Terms :
Carbonic Anhydrase IX/*antagonists & inhibitors
Carbonic Anhydrase Inhibitors/*pharmacology
Carbonic Anhydrases/*metabolism
Thiepins/*pharmacology
Antigens, Neoplasm/metabolism ; Carbonic Anhydrase IX/metabolism ; Carbonic Anhydrase Inhibitors/chemical synthesis ; Carbonic Anhydrase Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Humans ; Isoenzymes/antagonists & inhibitors ; Isoenzymes/metabolism ; Molecular Structure ; Structure-Activity Relationship ; Thiepins/chemical synthesis ; Thiepins/chemistry
Czasopismo naukowe
Tytuł :
Screening of benzenesulfonamide in combination with chemically diverse fragments against carbonic anhydrase by differential scanning fluorimetry.
Autorzy :
Krasavin M; Institute of Chemistry, Saint Petersburg State University, Saint Petersburg, Russian Federation.
Kalinin S; Institute of Chemistry, Saint Petersburg State University, Saint Petersburg, Russian Federation.
Zozulya S; Enamine Ltd, Kyiv, Ukraine.; Taras Shevchenko National University, Kyiv, Ukraine.
Gryniukova A; Enamine Ltd, Kyiv, Ukraine.
Borysko P; Enamine Ltd, Kyiv, Ukraine.
Angeli A; Neurofarba Department, Universita degli Studi di Firenze, Florence, Italy.
Supuran CT; Neurofarba Department, Universita degli Studi di Firenze, Florence, Italy.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 306-310.
Typ publikacji :
Journal Article
MeSH Terms :
Fluorometry*
Carbonic Anhydrase II/*antagonists & inhibitors
Carbonic Anhydrase IX/*antagonists & inhibitors
Carbonic Anhydrase Inhibitors/*pharmacology
Carbonic Anhydrases/*metabolism
Sulfonamides/*pharmacology
Carbonic Anhydrase II/metabolism ; Carbonic Anhydrase IX/metabolism ; Carbonic Anhydrase Inhibitors/chemical synthesis ; Carbonic Anhydrase Inhibitors/chemistry ; Drug Evaluation, Preclinical ; Humans ; Molecular Structure ; Sulfonamides/chemical synthesis ; Sulfonamides/chemistry
Czasopismo naukowe
Tytuł :
Novel benzofuran-based sulphonamides as selective carbonic anhydrases IX and XII inhibitors: synthesis and in vitro biological evaluation.
Autorzy :
Abdelrahman MA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Egyptian Russian University, Badr City, Egypt.
Eldehna WM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt.
Nocentini A; Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Firenze, Italy.
Ibrahim HS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Egyptian Russian University, Badr City, Egypt.
Almahli H; Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.
Abdel-Aziz HA; Department of Applied Organic Chemistry, National Research Center, Dokki, Egypt.
Abou-Seri SM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Supuran CT; Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Firenze, Italy.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 298-305.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Benzofurans/*pharmacology
Carbonic Anhydrase IX/*antagonists & inhibitors
Carbonic Anhydrase Inhibitors/*pharmacology
Carbonic Anhydrases/*metabolism
Sulfonamides/*pharmacology
Antigens, Neoplasm/metabolism ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Benzofurans/chemistry ; Carbonic Anhydrase IX/metabolism ; Carbonic Anhydrase Inhibitors/chemical synthesis ; Carbonic Anhydrase Inhibitors/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Molecular Docking Simulation ; Molecular Structure ; Structure-Activity Relationship ; Sulfonamides/chemical synthesis ; Sulfonamides/chemistry
Czasopismo naukowe
Tytuł :
A class of carbonic anhydrase IX/XII - selective carboxylate inhibitors.
Autorzy :
Alhameed RA; Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.
Berrino E; Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Florence, Italy.
Almarhoon Z; Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.
El-Faham A; Department of Chemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.; Chemistry Department, Faculty of Science, Alexandria University, Alexandria, Egypt.
Supuran CT; Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Florence, Italy.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 549-554.
Typ publikacji :
Journal Article
MeSH Terms :
Acetates/*pharmacology
Carbonic Anhydrase IX/*antagonists & inhibitors
Carbonic Anhydrase Inhibitors/*classification
Carbonic Anhydrase Inhibitors/*pharmacology
Carbonic Anhydrases/*metabolism
Thiazoles/*pharmacology
Acetates/chemical synthesis ; Acetates/chemistry ; Antigens, Neoplasm/metabolism ; Carbonic Anhydrase IX/metabolism ; Carbonic Anhydrase Inhibitors/chemical synthesis ; Carbonic Anhydrase Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Humans ; Molecular Structure ; Structure-Activity Relationship ; Thiazoles/chemical synthesis ; Thiazoles/chemistry
Czasopismo naukowe
Tytuł :
Coumarins from Magydaris pastinacea as inhibitors of the tumour-associated carbonic anhydrases IX and XII: isolation, biological studies and in silico evaluation.
Autorzy :
Fois B; Department of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy.
Distinto S; Department of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy.
Meleddu R; Department of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy.
Deplano S; Department of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy.
Maccioni E; Department of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy.
Floris C; Department of Chemical and Geological Sciences, University of Cagliari, Cagliari, Italy.
Rosa A; Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, Cagliari, Italy.
Nieddu M; Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria di Monserrato, Cagliari, Italy.
Caboni P; Department of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy.
Sissi C; Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy.
Angeli A; NEUROFARBA Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Firenze, Italy.
Supuran CT; NEUROFARBA Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Firenze, Italy.
Cottiglia F; Department of Life and Environmental Sciences, University of Cagliari, Cagliari, Italy.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 539-548.
Typ publikacji :
Journal Article
MeSH Terms :
Computer Simulation*
Apiaceae/*chemistry
Carbonic Anhydrase IX/*antagonists & inhibitors
Carbonic Anhydrase Inhibitors/*isolation & purification
Carbonic Anhydrase Inhibitors/*pharmacology
Carbonic Anhydrases/*metabolism
Coumarins/*isolation & purification
Coumarins/*pharmacology
Antigens, Neoplasm/metabolism ; Carbonic Anhydrase IX/metabolism ; Carbonic Anhydrase Inhibitors/chemistry ; Coumarins/chemistry ; Dose-Response Relationship, Drug ; Humans ; Molecular Structure ; Seeds/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
S-substituted 2-mercaptoquinazolin-4(3H)-one and 4-ethylbenzensulfonamides act as potent and selective human carbonic anhydrase IX and XII inhibitors.
Autorzy :
El-Azab AS; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Abdel-Aziz AA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Bua S; Department of Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Florence, Italy.
Nocentini A; Department of Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Florence, Italy.
AlSaif NA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Alanazi MM; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
El-Gendy MA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Ahmed HEA; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.; Pharmacognosy and Pharmaceutical Chemistry Department, College of Pharmacy, Taibah University, Al-Madinah Al-Munawarah, Saudi Arabia.
Supuran CT; Department of Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Florence, Italy.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 733-743.
Typ publikacji :
Journal Article
MeSH Terms :
Carbonic Anhydrase IX/*antagonists & inhibitors
Carbonic Anhydrase Inhibitors/*pharmacology
Carbonic Anhydrases/*metabolism
Quinazolinones/*pharmacology
Sulfonamides/*pharmacology
Antigens, Neoplasm/metabolism ; Carbonic Anhydrase IX/metabolism ; Carbonic Anhydrase Inhibitors/chemical synthesis ; Carbonic Anhydrase Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Humans ; Isoenzymes/antagonists & inhibitors ; Isoenzymes/metabolism ; Molecular Docking Simulation ; Molecular Structure ; Quinazolinones/chemistry ; Structure-Activity Relationship ; Sulfonamides/chemistry
Czasopismo naukowe
Tytuł :
Inclusion of a 5-fluorouracil moiety in nitrogenous bases derivatives as human carbonic anhydrase IX and XII inhibitors produced a targeted action against MDA-MB-231 and T47D breast cancer cells.
Autorzy :
Petreni A; University of Florence, Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, via Ugo Schiff 6, 50019, Sesto Fiorentino, Florence, Italy.
Bonardi A; University of Florence, Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, via Ugo Schiff 6, 50019, Sesto Fiorentino, Florence, Italy.
Lomelino C; University of Florida, Department of Biochemistry and Molecular Biology, 1200 Newell Dr, Gainesville, FL, 32610, USA.
Osman SM; Chemistry Department, College of Science, King Saud University, P. O. Box 2455, Riyadh, 11451, Saudi Arabia.
ALOthman ZA; Chemistry Department, College of Science, King Saud University, P. O. Box 2455, Riyadh, 11451, Saudi Arabia.
Eldehna WM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, 33516, Egypt.
El-Haggar R; Pharmaceutical Chemistry, Department, Faculty of Pharmacy, Helwan University, 11795, Cairo, Egypt.
McKenna R; University of Florida, Department of Biochemistry and Molecular Biology, 1200 Newell Dr, Gainesville, FL, 32610, USA.
Nocentini A; University of Florence, Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, via Ugo Schiff 6, 50019, Sesto Fiorentino, Florence, Italy. Electronic address: .
Supuran CT; University of Florence, Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, via Ugo Schiff 6, 50019, Sesto Fiorentino, Florence, Italy. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2020 Mar 15; Vol. 190, pp. 112112. Date of Electronic Publication: 2020 Feb 03.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Carbonic Anhydrase IX/*antagonists & inhibitors
Carbonic Anhydrase Inhibitors/*pharmacology
Fluorouracil/*analogs & derivatives
Fluorouracil/*pharmacology
Antigens, Neoplasm/chemistry ; Antigens, Neoplasm/metabolism ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/metabolism ; Apoptosis/drug effects ; Carbonic Anhydrase IX/chemistry ; Carbonic Anhydrase IX/metabolism ; Carbonic Anhydrase Inhibitors/chemical synthesis ; Carbonic Anhydrase Inhibitors/metabolism ; Carbonic Anhydrases/chemistry ; Carbonic Anhydrases/metabolism ; Catalytic Domain ; Cell Line, Tumor ; Coumarins/chemical synthesis ; Coumarins/metabolism ; Coumarins/pharmacology ; Crystallography, X-Ray ; Drug Design ; Drug Screening Assays, Antitumor ; Fluorouracil/metabolism ; G2 Phase Cell Cycle Checkpoints/drug effects ; Humans ; Molecular Structure ; Protein Binding ; Structure-Activity Relationship ; Sulfonamides/chemical synthesis ; Sulfonamides/metabolism ; Sulfonamides/pharmacology
Czasopismo naukowe
Tytuł :
Carbonic anhydrase 9 (CA9) expression in non-small-cell lung cancer: correlation with regulatory FOXP3+T-cell tumour stroma infiltration.
Autorzy :
Giatromanolaki A; Department of Pathology, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece.
Harris AL; Cancer Research UK, Molecular Oncology Laboratories, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Banham AH; Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, John Radcliffe Hospital, Oxford, OX3 9DU, UK.
Contrafouris CA; 1st Cardiac Surgery Department, Onassis Cardiac Surgery Center, 17674, Athens, Greece.
Koukourakis MI; Department of Radiotherapy/Oncology, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece. .
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Źródło :
British journal of cancer [Br J Cancer] 2020 Apr; Vol. 122 (8), pp. 1205-1210. Date of Electronic Publication: 2020 Feb 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antigens, Neoplasm/*physiology
Carbonic Anhydrase IX/*physiology
Carcinoma, Non-Small-Cell Lung/*enzymology
Forkhead Transcription Factors/*analysis
Lung Neoplasms/*enzymology
Lymphocytes, Tumor-Infiltrating/*immunology
T-Lymphocytes, Regulatory/*immunology
Adult ; Aged ; Aged, 80 and over ; Antigens, Neoplasm/analysis ; Carbonic Anhydrase IX/analysis ; Carcinoma, Non-Small-Cell Lung/immunology ; Carcinoma, Non-Small-Cell Lung/mortality ; Carcinoma, Non-Small-Cell Lung/pathology ; Female ; Humans ; Lung Neoplasms/immunology ; Lung Neoplasms/mortality ; Lung Neoplasms/pathology ; Male ; Middle Aged
Czasopismo naukowe
Tytuł :
1,3-Dipolar Cycloaddition, HPLC Enantioseparation, and Docking Studies of Saccharin/Isoxazole and Saccharin/Isoxazoline Derivatives as Selective Carbonic Anhydrase IX and XII Inhibitors.
Autorzy :
D'Ascenzio M; Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy.
Secci D; Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy.
Carradori S; Department of Pharmacy, 'G. d'Annunzio' University of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy.
Zara S; Department of Pharmacy, 'G. d'Annunzio' University of Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy.
Guglielmi P; Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy.
Cirilli R; Centro nazionale per il controllo e la valutazione dei farmaci, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.
Pierini M; Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy.
Poli G; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.
Tuccinardi T; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy.
Angeli A; Neurofarba Department, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Via U. Schiff 6, 50019 Sesto Fiorentino, Florence, Italy.; Centre of Advanced Research in Bionanoconjugates and Biopolymers Department, 'Petru Poni' Institute of Macromolecular Chemistry, 41A Grigore Ghica-Voda Alley, 700487 Iasi, Romania.
Supuran CT; Neurofarba Department, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Via U. Schiff 6, 50019 Sesto Fiorentino, Florence, Italy.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Mar 12; Vol. 63 (5), pp. 2470-2488. Date of Electronic Publication: 2020 Feb 04.
Typ publikacji :
Journal Article
MeSH Terms :
Antigens, Neoplasm/*metabolism
Carbonic Anhydrase IX/*metabolism
Carbonic Anhydrase Inhibitors/*chemistry
Carbonic Anhydrase Inhibitors/*pharmacology
Carbonic Anhydrases/*metabolism
Saccharin/*chemistry
Saccharin/*pharmacology
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Carbonic Anhydrase IX/antagonists & inhibitors ; Carbonic Anhydrase Inhibitors/chemical synthesis ; Cell Line ; Cycloaddition Reaction ; Humans ; Isoxazoles/chemical synthesis ; Isoxazoles/chemistry ; Isoxazoles/pharmacology ; MCF-7 Cells ; Molecular Docking Simulation ; Neoplasms/drug therapy ; Neoplasms/enzymology ; Neoplasms/metabolism ; Saccharin/chemical synthesis
Czasopismo naukowe
Tytuł :
TFAP2C regulates carbonic anhydrase XII in human breast cancer.
Autorzy :
Franke CM; Departments of Surgery, University of Iowa, Iowa City, IA, 52242, USA.
Gu VW; Departments of Surgery, University of Iowa, Iowa City, IA, 52242, USA.
Grimm BG; Departments of Surgery, University of Iowa, Iowa City, IA, 52242, USA.
Cassady VC; Departments of Surgery, University of Iowa, Iowa City, IA, 52242, USA.
White JR; Departments of Surgery, University of Iowa, Iowa City, IA, 52242, USA.
Weigel RJ; Departments of Surgery, University of Iowa, Iowa City, IA, 52242, USA.; Departments of Biochemistry, University of Iowa, Iowa City, IA, 52242, USA.
Kulak MV; Departments of Surgery, University of Iowa, Iowa City, IA, 52242, USA. .
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Źródło :
Oncogene [Oncogene] 2020 Feb; Vol. 39 (6), pp. 1290-1301. Date of Electronic Publication: 2019 Oct 21.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Neoplastic*
Antigens, Neoplasm/*metabolism
Biomarkers, Tumor/*metabolism
Breast Neoplasms/*pathology
Carbonic Anhydrase IX/*metabolism
Estrogen Receptor alpha/*metabolism
Transcription Factor AP-2/*metabolism
Antigens, Neoplasm/genetics ; Apoptosis ; Biomarkers, Tumor/genetics ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Carbonic Anhydrase IX/genetics ; Cell Proliferation ; DNA Methylation ; Estrogen Receptor alpha/genetics ; Female ; Humans ; Prognosis ; Transcription Factor AP-2/genetics ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Carbonic Anhydrase IX-Mouse versus Human.
Autorzy :
Takacova M; Biomedical Research Center, Institute of Virology, Department of Tumor Biology, Slovak Academy of Sciences, Dubravska cesta 9, 84505 Bratislava, Slovakia.
Barathova M; Biomedical Research Center, Institute of Virology, Department of Tumor Biology, Slovak Academy of Sciences, Dubravska cesta 9, 84505 Bratislava, Slovakia.
Zatovicova M; Biomedical Research Center, Institute of Virology, Department of Tumor Biology, Slovak Academy of Sciences, Dubravska cesta 9, 84505 Bratislava, Slovakia.
Golias T; Biomedical Research Center, Institute of Virology, Department of Tumor Biology, Slovak Academy of Sciences, Dubravska cesta 9, 84505 Bratislava, Slovakia.
Kajanova I; Biomedical Research Center, Institute of Virology, Department of Tumor Biology, Slovak Academy of Sciences, Dubravska cesta 9, 84505 Bratislava, Slovakia.
Jelenska L; Biomedical Research Center, Institute of Virology, Department of Tumor Biology, Slovak Academy of Sciences, Dubravska cesta 9, 84505 Bratislava, Slovakia.
Sedlakova O; Biomedical Research Center, Institute of Virology, Department of Tumor Biology, Slovak Academy of Sciences, Dubravska cesta 9, 84505 Bratislava, Slovakia.
Svastova E; Biomedical Research Center, Institute of Virology, Department of Tumor Biology, Slovak Academy of Sciences, Dubravska cesta 9, 84505 Bratislava, Slovakia.
Kopacek J; Biomedical Research Center, Institute of Virology, Department of Tumor Biology, Slovak Academy of Sciences, Dubravska cesta 9, 84505 Bratislava, Slovakia.
Pastorekova S; Biomedical Research Center, Institute of Virology, Department of Tumor Biology, Slovak Academy of Sciences, Dubravska cesta 9, 84505 Bratislava, Slovakia.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2019 Dec 30; Vol. 21 (1). Date of Electronic Publication: 2019 Dec 30.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation*
Antigens, Neoplasm/*genetics
Antigens, Neoplasm/*metabolism
Carbonic Anhydrase IX/*genetics
Carbonic Anhydrase IX/*metabolism
Animals ; Antigens, Neoplasm/chemistry ; Binding Sites ; Carbonic Anhydrase IX/chemistry ; Cell Adhesion ; Cell Movement ; Exosomes ; Humans ; Hydrogen-Ion Concentration ; Hypoxia ; Mice ; Promoter Regions, Genetic ; Protein Domains
Czasopismo naukowe
Tytuł :
Assessment of the antiproliferative and apoptotic roles of sulfonamide carbonic anhydrase IX inhibitors in HeLa cancer cell line.
Autorzy :
Koyuncu I; a Department of Biochemistry, Faculty of Medicine , Harran University , Sanliurfa , Turkey.
Gonel A; a Department of Biochemistry, Faculty of Medicine , Harran University , Sanliurfa , Turkey.
Durgun M; b Department of Chemistry, Faculty of Arts and Sciences , Harran University , Sanliurfa , Turkey.
Kocyigit A; c Department of Medical Biochemistry, Faculty of Medicine , Bezmialem Vakif University , Istanbul , Turkey.
Yuksekdag O; a Department of Biochemistry, Faculty of Medicine , Harran University , Sanliurfa , Turkey.
Supuran CT; d Neurofarba Dept., Section of Pharmaceutical and Nutriceutical Sciences , Università degli Studi di Firenze , Sesto Fiorentino (Florence) , Italy.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2019 Dec; Vol. 34 (1), pp. 75-86.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Apoptosis/*drug effects
Carbonic Anhydrase IX/*antagonists & inhibitors
Carbonic Anhydrase Inhibitors/*pharmacology
Antigens, Neoplasm/genetics ; Antigens, Neoplasm/metabolism ; Antineoplastic Combined Chemotherapy Protocols/chemistry ; Carbonic Anhydrase IX/genetics ; Carbonic Anhydrase IX/metabolism ; Carbonic Anhydrase Inhibitors/chemistry ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; DNA Damage ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; HeLa Cells ; Humans ; Hydrogen-Ion Concentration ; Membrane Potential, Mitochondrial/drug effects ; Molecular Structure ; Reactive Oxygen Species/analysis ; Reactive Oxygen Species/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Targeting hypoxia downstream signaling protein, CAIX, for CAR T-cell therapy against glioblastoma.
Autorzy :
Cui J; Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Zhang Q; Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Song Q; Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Wang H; Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Dmitriev P; Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Sun MY; Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.
Cao X; Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Wang Y; Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Guo L; Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.
Indig IH; Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Rosenblum JS; Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Ji C; Immunology Laboratory, Neurosurgical Institute of Fudan University, Shanghai, China.
Cao D; Immunology Laboratory, Neurosurgical Institute of Fudan University, Shanghai, China.
Yang K; Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.; Oaiscell Biotechnologies Inc, Bethesda, Maryland, USA.
Gilbert MR; Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Yao Y; Immunology Laboratory, Neurosurgical Institute of Fudan University, Shanghai, China.; Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
Zhuang Z; Neuro-Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.; Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.
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Źródło :
Neuro-oncology [Neuro Oncol] 2019 Nov 04; Vol. 21 (11), pp. 1436-1446.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms :
Biomarkers, Tumor/*metabolism
Carbonic Anhydrase IX/*antagonists & inhibitors
Glioblastoma/*therapy
Immunotherapy, Adoptive/*methods
Lymphocytes, Tumor-Infiltrating/*immunology
Tumor Microenvironment/*immunology
Animals ; Antigens, Neoplasm/immunology ; Antigens, Neoplasm/metabolism ; Apoptosis ; Carbonic Anhydrase IX/immunology ; Carbonic Anhydrase IX/metabolism ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Glioblastoma/immunology ; Glioblastoma/metabolism ; Glioblastoma/pathology ; Humans ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Prognosis ; Signal Transduction ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Prostate cancer cells and exosomes in acidic condition show increased carbonic anhydrase IX expression and activity.
Autorzy :
Logozzi M; a Department of Oncology and Molecular Medicine , National Institute of Health , Rome , Italy.
Capasso C; b National Research Council , Institute of Biosciences and BioResources , Naples , Italy.
Di Raimo R; a Department of Oncology and Molecular Medicine , National Institute of Health , Rome , Italy.
Del Prete S; b National Research Council , Institute of Biosciences and BioResources , Naples , Italy.
Mizzoni D; a Department of Oncology and Molecular Medicine , National Institute of Health , Rome , Italy.
Falchi M; c National AIDS Center , National Institute of Health , Rome , Italy.
Supuran CT; d NEUROFARBA Department , University of Florence, Section of Pharmaceutical Chemistry , Florence , Italy.
Fais S; a Department of Oncology and Molecular Medicine , National Institute of Health , Rome , Italy.
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Źródło :
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2019 Dec; Vol. 34 (1), pp. 272-278.
Typ publikacji :
Journal Article
MeSH Terms :
Antigens, Neoplasm/*metabolism
Carbonic Anhydrase IX/*metabolism
Exosomes/*metabolism
Prostatic Neoplasms/*metabolism
Antigens, Neoplasm/biosynthesis ; Carbonic Anhydrase IX/biosynthesis ; Cell Line, Tumor ; Exosomes/pathology ; Humans ; Hydrogen-Ion Concentration ; Male ; Microscopy, Confocal ; Prostatic Neoplasms/pathology
Czasopismo naukowe

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