Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Wyszukujesz frazę ""Carbonic Anhydrase IX"" wg kryterium: Temat


Tytuł:
The prognostic impact of a combined carbonic anhydrase IX and Ki67 signature in oral squamous cell carcinoma.
Autorzy:
Klimowicz AC; 1] Department of Oncology, University of Calgary, 1331 - 29 Street NW, Calgary, Alberta, Canada T2N 4N2 [2] Functional Tissue Imaging Unit, Translational Laboratories, Tom Baker Cancer Centre, 1331 - 29 Street NW, Calgary, Alberta, Canada T2N 4N2.
Bose P
Petrillo SK
Magliocco AM
Dort JC
Brockton NT
Pokaż więcej
Źródło:
British journal of cancer [Br J Cancer] 2013 Oct 01; Vol. 109 (7), pp. 1859-66. Date of Electronic Publication: 2013 Sep 05.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antigens, Neoplasm/*metabolism
Carbonic Anhydrases/*metabolism
Carcinoma, Squamous Cell/*metabolism
Ki-67 Antigen/*metabolism
Mouth Neoplasms/*metabolism
bcl-2-Associated X Protein/*metabolism
Apoptosis ; Biomarkers, Tumor/metabolism ; Carbonic Anhydrase IX ; Carcinoma, Squamous Cell/mortality ; Cell Hypoxia ; Drug Resistance, Neoplasm ; Female ; Humans ; Male ; Middle Aged ; Mouth Neoplasms/mortality ; Prognosis ; Survival ; Treatment Outcome
Czasopismo naukowe
Tytuł:
Endocervical glandular neoplasia associated with lobular endocervical glandular hyperplasia is HPV-independent and correlates with carbonic anhydrase-IX expression: a Gynaecological Oncology Group Study.
Autorzy:
Liao SY; Department of Epidemiology, University of California, Irvine, School of Medicine, Irvine, CA, USA.
Rodgers WH
Kauderer J
Darcy KM
Carter R
Susumu N
Nagao S
Walker JL
Hatae M
Stanbridge EJ
Pokaż więcej
Źródło:
British journal of cancer [Br J Cancer] 2013 Feb 19; Vol. 108 (3), pp. 613-20. Date of Electronic Publication: 2013 Jan 08.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Antigens, Neoplasm/*metabolism
Biomarkers, Tumor/*metabolism
Carbonic Anhydrases/*metabolism
Hyperplasia/*pathology
Neoplasms, Glandular and Epithelial/*pathology
Papillomavirus Infections/*pathology
Uterine Cervical Neoplasms/*pathology
Adenocarcinoma, Mucinous/enzymology ; Adenocarcinoma, Mucinous/pathology ; Adenocarcinoma, Mucinous/virology ; Adult ; Aged ; Aged, 80 and over ; Carbonic Anhydrase IX ; Carcinoma, Lobular/enzymology ; Carcinoma, Lobular/pathology ; Carcinoma, Lobular/virology ; DNA, Viral/genetics ; Female ; Humans ; Hyperplasia/enzymology ; Hyperplasia/virology ; Immunoenzyme Techniques ; Male ; Middle Aged ; Neoplasms, Glandular and Epithelial/enzymology ; Neoplasms, Glandular and Epithelial/virology ; Papillomaviridae/genetics ; Papillomavirus Infections/enzymology ; Papillomavirus Infections/virology ; Polymerase Chain Reaction ; Prognosis ; Stomach Neoplasms/enzymology ; Stomach Neoplasms/pathology ; Stomach Neoplasms/virology ; Uterine Cervical Neoplasms/enzymology ; Uterine Cervical Neoplasms/virology
Czasopismo naukowe
Tytuł:
Immunohistochemical markers of the hypoxic response can identify malignancy in phaeochromocytomas and paragangliomas and optimize the detection of tumours with VHL germline mutations.
Autorzy:
Pinato DJ; Department of Investigative Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.
Ramachandran R
Toussi ST
Vergine M
Ngo N
Sharma R
Lloyd T
Meeran K
Palazzo F
Martin N
Khoo B
Dina R
Tan TM
Pokaż więcej
Źródło:
British journal of cancer [Br J Cancer] 2013 Feb 05; Vol. 108 (2), pp. 429-37. Date of Electronic Publication: 2012 Dec 20.
Typ publikacji:
Journal Article
MeSH Terms:
Antigens, Neoplasm/*analysis
Carbonic Anhydrases/*analysis
Hypoxia-Inducible Factor 1, alpha Subunit/*analysis
Paraganglioma/*chemistry
Paraganglioma/*genetics
Pheochromocytoma/*chemistry
Pheochromocytoma/*genetics
Von Hippel-Lindau Tumor Suppressor Protein/*genetics
Adrenal Gland Neoplasms/diagnosis ; Adrenal Gland Neoplasms/genetics ; Adrenal Gland Neoplasms/immunology ; Adult ; Antigens, Neoplasm/immunology ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/immunology ; Carbonic Anhydrase IX ; Carbonic Anhydrases/immunology ; Cell Hypoxia ; Female ; Germ-Line Mutation ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/immunology ; Immunohistochemistry ; Male ; Neoplasm Metastasis ; Paraganglioma/diagnosis ; Pheochromocytoma/diagnosis ; Proto-Oncogene Proteins c-akt/analysis ; Proto-Oncogene Proteins c-akt/immunology ; TOR Serine-Threonine Kinases/analysis ; TOR Serine-Threonine Kinases/immunology ; Tissue Array Analysis ; Vascular Endothelial Growth Factor A/analysis ; Vascular Endothelial Growth Factor A/immunology ; von Hippel-Lindau Disease/diagnosis ; von Hippel-Lindau Disease/genetics
Czasopismo naukowe
Tytuł:
Lacking hypoxia-mediated downregulation of E-cadherin in cancers of the uterine cervix.
Autorzy:
Mayer A; Department of Radiooncology and Radiotherapy, University Medical Center, Mainz, Germany. />Höckel M
Schlischewsky N
Schmidberger H
Horn LC
Vaupel P
Pokaż więcej
Źródło:
British journal of cancer [Br J Cancer] 2013 Feb 05; Vol. 108 (2), pp. 402-8. Date of Electronic Publication: 2013 Jan 15.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cell Hypoxia*
Epithelial-Mesenchymal Transition*
Cadherins/*metabolism
Uterine Cervical Neoplasms/*metabolism
Antigens, Neoplasm/metabolism ; Biomarkers, Tumor/metabolism ; Carbonic Anhydrase IX ; Carbonic Anhydrases/metabolism ; Carcinoma, Squamous Cell/metabolism ; Cervix Uteri/metabolism ; Cervix Uteri/pathology ; Down-Regulation ; Female ; Glucose Transporter Type 1/metabolism ; Humans ; Ki-67 Antigen/metabolism ; Middle Aged
Czasopismo naukowe
Tytuł:
Carbonic anhydrase IX is a predictive marker of doxorubicin resistance in early-stage breast cancer independent of HER2 and TOP2A amplification.
Autorzy:
Betof AS; Department of Pathology, Duke University Medical Center, Research Drive, Box 3455 DUMC, Durham, NC, USA.
Rabbani ZN
Hardee ME
Kim SJ
Broadwater G
Bentley RC
Snyder SA
Vujaskovic Z
Oosterwijk E
Harris LN
Horton JK
Dewhirst MW
Blackwell KL
Pokaż więcej
Źródło:
British journal of cancer [Br J Cancer] 2012 Feb 28; Vol. 106 (5), pp. 916-22. Date of Electronic Publication: 2012 Feb 14.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Drug Resistance, Neoplasm*
Antibiotics, Antineoplastic/*therapeutic use
Antigens, Neoplasm/*metabolism
Breast Neoplasms/*drug therapy
Carbonic Anhydrases/*metabolism
Doxorubicin/*therapeutic use
Adult ; Aged ; Antigens, Neoplasm/genetics ; Biomarkers, Tumor ; Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Carbonic Anhydrase IX ; Cell Hypoxia ; Chemotherapy, Adjuvant ; DNA Topoisomerases, Type II/genetics ; DNA-Binding Proteins/genetics ; Disease-Free Survival ; Female ; Gene Amplification ; Genes, erbB-2 ; Humans ; Middle Aged ; Poly-ADP-Ribose Binding Proteins
Czasopismo naukowe
Tytuł:
Vascular phenotypes in primary non-small cell lung carcinomas and matched brain metastases.
Autorzy:
Jubb AM; Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Level 4-Academic Block, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9DU, UK. />Cesario A
Ferguson M
Congedo MT
Gatter KC
Lococo F
Mulè A
Pezzella F
Pokaż więcej
Źródło:
British journal of cancer [Br J Cancer] 2011 Jun 07; Vol. 104 (12), pp. 1877-81. Date of Electronic Publication: 2011 May 03.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Brain Neoplasms/*secondary
Carcinoma, Non-Small-Cell Lung/*blood supply
Lung Neoplasms/*blood supply
Angiogenesis Inhibitors/therapeutic use ; Antigens, Neoplasm/analysis ; Carbonic Anhydrase IX ; Carbonic Anhydrases/analysis ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/pathology ; Cell Hypoxia ; Cell Proliferation ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/pathology ; Phenotype ; Vascular Endothelial Growth Factor A/analysis
Czasopismo naukowe
Tytuł:
Tumour necrosis is a postoperative prognostic marker for pancreatic cancer patients with a high interobserver reproducibility in histological evaluation.
Autorzy:
Hiraoka N; Pathology Division, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. />Ino Y
Sekine S
Tsuda H
Shimada K
Kosuge T
Zavada J
Yoshida M
Yamada K
Koyama T
Kanai Y
Pokaż więcej
Źródło:
British journal of cancer [Br J Cancer] 2010 Sep 28; Vol. 103 (7), pp. 1057-65. Date of Electronic Publication: 2010 Aug 24.
Typ publikacji:
Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antigens, Neoplasm/*metabolism
Carbonic Anhydrases/*metabolism
Carcinoma, Pancreatic Ductal/*pathology
Pancreatic Neoplasms/*pathology
Carbonic Anhydrase IX ; Carcinoma, Pancreatic Ductal/mortality ; Cell Hypoxia ; Female ; Humans ; Male ; Middle Aged ; Pancreatic Neoplasms/mortality ; Pancreatic Neoplasms/surgery ; Postoperative Period ; Prognosis ; Reproducibility of Results
Czasopismo naukowe
Tytuł:
High levels of carbonic anhydrase IX in tumour tissue and plasma are biomarkers of poor prognostic in patients with non-small cell lung cancer.
Autorzy:
Ilie M; Laboratory of Clinical and Experimental Pathology, Louis Pasteur Hospital, Nice, France.
Mazure NM
Hofman V
Ammadi RE
Ortholan C
Bonnetaud C
Havet K
Venissac N
Mograbi B
Mouroux J
Pouysségur J
Hofman P
Pokaż więcej
Źródło:
British journal of cancer [Br J Cancer] 2010 May 25; Vol. 102 (11), pp. 1627-35. Date of Electronic Publication: 2010 May 11.
Typ publikacji:
Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antigens, Neoplasm/*blood
Antigens, Neoplasm/*metabolism
Carbonic Anhydrases/*blood
Carbonic Anhydrases/*metabolism
Carcinoma, Non-Small-Cell Lung/*diagnosis
Lung Neoplasms/*diagnosis
Adult ; Aged ; Biomarkers, Tumor/blood ; Biomarkers, Tumor/metabolism ; Carbonic Anhydrase IX ; Carcinoma, Non-Small-Cell Lung/blood ; Carcinoma, Non-Small-Cell Lung/metabolism ; Carcinoma, Non-Small-Cell Lung/mortality ; Cell Hypoxia/physiology ; Cell Proliferation ; Cells, Cultured ; Female ; Humans ; Immunohistochemistry ; Lung Neoplasms/blood ; Lung Neoplasms/metabolism ; Lung Neoplasms/mortality ; Male ; Middle Aged ; Prognosis ; Tissue Array Analysis ; Up-Regulation
Czasopismo naukowe
Tytuł:
Human monoclonal antibodies targeting carbonic anhydrase IX for the molecular imaging of hypoxic regions in solid tumours.
Autorzy:
Ahlskog JK; Department of Chemistry and Applied Biosciences, ETH Zürich, Wolfgang-Pauli-Strasse 10, Zurich CH-8093, Switzerland.
Schliemann C
Mårlind J
Qureshi U
Ammar A
Pedley RB
Neri D
Pokaż więcej
Źródło:
British journal of cancer [Br J Cancer] 2009 Aug 18; Vol. 101 (4), pp. 645-57. Date of Electronic Publication: 2009 Jul 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antibodies, Monoclonal*/immunology
Antibodies, Monoclonal*/pharmacokinetics
Antibody Specificity/*immunology
Antigens, Neoplasm/*immunology
Carbonic Anhydrases/*immunology
Diagnostic Imaging/*methods
Hypoxia/*pathology
Neoplasms/*enzymology
Animals ; Carbonic Anhydrase IX ; Flow Cytometry ; Fluorescent Antibody Technique ; Humans ; Mice ; Mice, Nude ; Microscopy, Fluorescence ; Neoplasms/immunology ; Neoplasms/pathology ; T-Phages ; Tissue Distribution
Czasopismo naukowe
Tytuł:
Expression of carbonic anhydrase IX suggests poor response to therapy in rectal cancer.
Autorzy:
Span PN
Nagtegaal ID
Bussink J
Pokaż więcej
Źródło:
British journal of cancer [Br J Cancer] 2009 Jul 21; Vol. 101 (2), pp. 372; author reply 373. Date of Electronic Publication: 2009 Jun 30.
Typ publikacji:
Letter; Comment
MeSH Terms:
Antigens, Neoplasm/*biosynthesis
Biomarkers, Tumor/*biosynthesis
Carbonic Anhydrases/*biosynthesis
Rectal Neoplasms/*enzymology
Rectal Neoplasms/*therapy
Carbonic Anhydrase IX ; Humans
Opinia redakcyjna
Tytuł:
Expression of carbonic anhydrase IX suggests poor outcome in rectal cancer.
Autorzy:
Korkeila E; Department of Oncology and Radiotherapy, Turku University Hospital, Savitehtaankatu 1, PB 52, Turku FIN-20521, Finland. />Talvinen K
Jaakkola PM
Minn H
Syrjänen K
Sundström J
Pyrhönen S
Pokaż więcej
Źródło:
British journal of cancer [Br J Cancer] 2009 Mar 24; Vol. 100 (6), pp. 874-80. Date of Electronic Publication: 2009 Feb 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Antigens, Neoplasm/*analysis
Carbonic Anhydrases/*analysis
Rectal Neoplasms/*enzymology
Rectal Neoplasms/*mortality
Aged ; Biopsy ; Carbonic Anhydrase IX ; Female ; Humans ; Immunohistochemistry ; Male ; Prognosis ; Proportional Hazards Models ; Rectal Neoplasms/therapy
Czasopismo naukowe
Tytuł:
Expression of carbonic anhydrase 9, a potential intrinsic marker of hypoxia, is associated with poor prognosis in oesophageal squamous cell carcinoma.
Autorzy:
Tanaka N; Department of General Surgical Science, Gunma University, Graduate School of Medicine, Maebashi, Japan. />Kato H
Inose T
Kimura H
Faried A
Sohda M
Nakajima M
Fukai Y
Miyazaki T
Masuda N
Fukuchi M
Kuwano H
Pokaż więcej
Źródło:
British journal of cancer [Br J Cancer] 2008 Nov 04; Vol. 99 (9), pp. 1468-75. Date of Electronic Publication: 2008 Oct 07.
Typ publikacji:
Journal Article
MeSH Terms:
Antigens, Neoplasm/*analysis
Carbonic Anhydrases/*analysis
Carcinoma, Squamous Cell/*enzymology
Esophageal Neoplasms/*enzymology
Adult ; Aged ; Antigens, Neoplasm/genetics ; Biomarkers ; Carbonic Anhydrase IX ; Carbonic Anhydrases/genetics ; Carcinoma, Squamous Cell/mortality ; Carcinoma, Squamous Cell/pathology ; Cell Hypoxia ; Cell Line, Tumor ; Cell Proliferation ; Esophageal Neoplasms/mortality ; Esophageal Neoplasms/pathology ; Female ; Humans ; Male ; Middle Aged ; Prognosis ; RNA, Messenger/analysis ; Reverse Transcriptase Polymerase Chain Reaction ; Survival Rate
Czasopismo naukowe
Tytuł:
Poorer outcome in stromal HIF-2 alpha- and CA9-positive colorectal adenocarcinomas is associated with wild-type TP53 but not with BNIP3 promoter hypermethylation or apoptosis.
Autorzy:
Cleven AH; Department of Pathology, GROW - School for Oncology and Developmental Biology, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands.
Wouters BG
Schutte B
Spiertz AJ
van Engeland M
de Bruïne AP
Pokaż więcej
Źródło:
British journal of cancer [Br J Cancer] 2008 Sep 02; Vol. 99 (5), pp. 727-33. Date of Electronic Publication: 2008 Aug 19.
Typ publikacji:
Journal Article; Multicenter Study
MeSH Terms:
Apoptosis*
DNA Methylation*
Genes, p53*
Promoter Regions, Genetic*
Adenocarcinoma/*pathology
Antigens, Neoplasm/*metabolism
Basic Helix-Loop-Helix Transcription Factors/*metabolism
Carbonic Anhydrases/*metabolism
Colorectal Neoplasms/*pathology
Membrane Proteins/*genetics
Proto-Oncogene Proteins/*genetics
Stromal Cells/*metabolism
Adenocarcinoma/genetics ; Adenocarcinoma/metabolism ; Carbonic Anhydrase IX ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Humans ; Immunohistochemistry ; Mutation ; Prospective Studies ; Survival Analysis ; Treatment Outcome
Czasopismo naukowe
Tytuł:
Alternative splicing variant of the hypoxia marker carbonic anhydrase IX expressed independently of hypoxia and tumour phenotype.
Autorzy:
Barathova M; Centre of Molecular Medicine, Institute of Virology, Slovak Academy of Sciences, Dubravska cesta 9, Bratislava 845 05, Slovak Republic.
Takacova M
Holotnakova T
Gibadulinova A
Ohradanova A
Zatovicova M
Hulikova A
Kopacek J
Parkkila S
Supuran CT
Pastorekova S
Pastorek J
Pokaż więcej
Źródło:
British journal of cancer [Br J Cancer] 2008 Jan 15; Vol. 98 (1), pp. 129-36. Date of Electronic Publication: 2007 Nov 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alternative Splicing*
Antigens, Neoplasm/*genetics
Biomarkers, Tumor/*genetics
Carbonic Anhydrases/*genetics
Hypoxia/*genetics
Neoplasms/*genetics
Antigens, Neoplasm/metabolism ; Biomarkers, Tumor/metabolism ; Carbonic Anhydrase IX ; Carbonic Anhydrase Inhibitors/pharmacology ; Carbonic Anhydrases/metabolism ; Cells, Cultured ; Humans ; Hypoxia/metabolism ; Immunoblotting ; Immunoprecipitation ; Neoplasms/enzymology ; Neoplasms/pathology ; Phenotype ; Polymerase Chain Reaction ; RNA, Messenger/metabolism ; Transfection ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł:
Carbonic anhydrase IX expression is more predictive than prognostic in breast cancer.
Autorzy:
Span PN
Bussink J
De Mulder PH
Sweep FC
Pokaż więcej
Źródło:
British journal of cancer [Br J Cancer] 2007 Apr 23; Vol. 96 (8), pp. 1309; author reply 1310. Date of Electronic Publication: 2007 Mar 27.
Typ publikacji:
Letter; Comment
MeSH Terms:
Antigens, Neoplasm/*biosynthesis
Biomarkers, Tumor/*biosynthesis
Breast Neoplasms/*enzymology
Carbonic Anhydrases/*biosynthesis
Breast Neoplasms/mortality ; Carbonic Anhydrase IX ; Female ; Humans ; Predictive Value of Tests ; Prognosis
Opinia redakcyjna
Tytuł:
Ectodomain shedding of the hypoxia-induced carbonic anhydrase IX is a metalloprotease-dependent process regulated by TACE/ADAM17.
Autorzy:
Zatovicova M; Center of Molecular Medicine, Institute of Virology, Slovak Academy of Sciences, Dubravska cesta 9, Bratislava 845 05, Slovak Republic.
Sedlakova O
Svastova E
Ohradanova A
Ciampor F
Arribas J
Pastorek J
Pastorekova S
Pokaż więcej
Źródło:
British journal of cancer [Br J Cancer] 2005 Nov 28; Vol. 93 (11), pp. 1267-76.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
ADAM Proteins/*physiology
Antigens, Neoplasm/*metabolism
Carbonic Anhydrases/*metabolism
Metalloproteases/*metabolism
ADAM17 Protein ; Carbonic Anhydrase IX ; Carcinoma/pathology ; Carcinoma, Renal Cell/pathology ; Cell Adhesion ; Cell Hypoxia ; Colonic Neoplasms/pathology ; Enzyme Induction ; HeLa Cells ; Humans ; Hydrogen-Ion Concentration ; Kidney Neoplasms/pathology ; Prognosis ; Signal Transduction
Czasopismo naukowe
Tytuł:
Coexpression of epidermal growth factor receptor with related factors is associated with a poor prognosis in non-small-cell lung cancer.
Autorzy:
Swinson DE; Cancer Centre, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK. />Cox G
O'Byrne KJ
Pokaż więcej
Źródło:
British journal of cancer [Br J Cancer] 2004 Oct 04; Vol. 91 (7), pp. 1301-7.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression Regulation, Neoplastic*
Models, Theoretical*
Antigens, Neoplasm/*biosynthesis
Biomarkers, Tumor/*biosynthesis
Carbonic Anhydrases/*biosynthesis
Carcinoma, Non-Small-Cell Lung/*genetics
Carcinoma, Non-Small-Cell Lung/*pathology
ErbB Receptors/*biosynthesis
Lung Neoplasms/*genetics
Lung Neoplasms/*pathology
Adult ; Aged ; Antigens, Neoplasm/analysis ; Carbonic Anhydrase IX ; Female ; Gene Expression Profiling ; Humans ; Immunohistochemistry ; Male ; Matrix Metalloproteinase 9/biosynthesis ; Middle Aged ; Prognosis ; Retrospective Studies
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies