Temat: "Carbonic Anhydrase IX" - OpacWWW

Skocz do pozycji: 1.

Tytuł:: Discovery of 2,4-thiazolidinedione-tethered coumarins as novel selective inhibitors for carbonic anhydrase IX and XII isoforms.
Autorzy:: Eldehna WM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt.
Taghour MS; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.
Al-Warhi T; Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
Nocentini A; Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Firenze, Italy.
Elbadawi MM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt.
Mahdy HA; Pharmaceutical Medicinal Chemistry & Drug Design Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.
Abdelrahman MA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Egyptian Russian University, Cairo, Egypt.
Alotaibi OJ; Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
Aljaeed N; Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
Elimam DM; Department of Pharmacognosy, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt.; School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom.
Afarinkia K; Institute of Cancer Therapeutics, University of Bradford, Bradford, United Kingdom.
Abdel-Aziz HA; Department of Applied Organic Chemistry, National Research Center, Giza, Egypt.
Supuran CT; Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Firenze, Italy.; Pokaż więcej
Źródło:: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 531-541.
Typ publikacji:: Journal Article
MeSH Terms:: Drug Discovery*
Carbonic Anhydrase IX/*antagonists & inhibitors
Carbonic Anhydrase Inhibitors/*pharmacology
Carbonic Anhydrases/*metabolism
Coumarins/*pharmacology
Thiazolidinediones/*pharmacology
Antigens, Neoplasm/metabolism ; Apoptosis/drug effects ; Carbonic Anhydrase IX/metabolism ; Carbonic Anhydrase Inhibitors/chemical synthesis ; Carbonic Anhydrase Inhibitors/chemistry ; Cell Cycle/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Coumarins/chemical synthesis ; Coumarins/chemistry ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; MCF-7 Cells ; Molecular Structure ; Structure-Activity Relationship ; Thiazolidinediones/chemical synthesis ; Thiazolidinediones/chemistry

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Skocz do pozycji: 2.

Tytuł:: Isocoumarins: a new class of selective carbonic anhydrase IX and XII inhibitors.
Autorzy:: Onyılmaz M; Faculty of Science and Arts, Department of Chemistry, Harran University, Şanlıurfa, Turkey.
Koca M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Adıyaman University, Adıyaman, Turkey.
Bonardi A; Department of Neurofarba, Sezione di Scienze Farmaceutiche, Università degli Studi di Firenze, Sesto Fiorentino, Italy.
Degirmenci M; Faculty of Science and Arts, Department of Chemistry, Harran University, Şanlıurfa, Turkey.
Supuran CT; Department of Neurofarba, Sezione di Scienze Farmaceutiche, Università degli Studi di Firenze, Sesto Fiorentino, Italy.; Pokaż więcej
Źródło:: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 743-748.
Typ publikacji:: Journal Article
MeSH Terms:: Carbonic Anhydrase IX/*antagonists & inhibitors
Carbonic Anhydrase Inhibitors/*pharmacology
Carbonic Anhydrases/*metabolism
Isocoumarins/*pharmacology
Antigens, Neoplasm/metabolism ; Carbonic Anhydrase IX/metabolism ; Carbonic Anhydrase Inhibitors/chemical synthesis ; Carbonic Anhydrase Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Isocoumarins/chemical synthesis ; Isocoumarins/chemistry ; Molecular Structure ; Structure-Activity Relationship

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Skocz do pozycji: 3.

Tytuł:: The three-tails approach as a new strategy to improve selectivity of action of sulphonamide inhibitors against tumour-associated carbonic anhydrase IX and XII.
Autorzy:: Bonardi A; Department NEUROFARBA - Pharmaceutical and Nutraceutical Section, University of Firenze, Florence, Italy.; Department NEUROFARBA - Pharmaceutical and Nutraceutical Section, Laboratory of Molecular Modeling Cheminformatics & QSAR, University of Firenze, Florence, Italy.
Bua S; Department NEUROFARBA - Pharmaceutical and Nutraceutical Section, University of Firenze, Florence, Italy.
Combs J; Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, FL, USA.
Lomelino C; Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, FL, USA.
Andring J; Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, FL, USA.
Osman SM; Chemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia.
Toti A; Department NEUROFARBA - Pharmaceutical and Nutraceutical Section, University of Firenze, Florence, Italy.
Di Cesare Mannelli L; Department NEUROFARBA - Pharmaceutical and Nutraceutical Section, University of Firenze, Florence, Italy.
Gratteri P; Department NEUROFARBA - Pharmaceutical and Nutraceutical Section, Laboratory of Molecular Modeling Cheminformatics & QSAR, University of Firenze, Florence, Italy.
Ghelardini C; Department NEUROFARBA - Pharmaceutical and Nutraceutical Section, University of Firenze, Florence, Italy.
McKenna R; Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, FL, USA.
Nocentini A; Department NEUROFARBA - Pharmaceutical and Nutraceutical Section, University of Firenze, Florence, Italy.
Supuran CT; Department NEUROFARBA - Pharmaceutical and Nutraceutical Section, University of Firenze, Florence, Italy.; Pokaż więcej
Źródło:: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2022 Dec; Vol. 37 (1), pp. 930-939.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents/*pharmacology
Carbonic Anhydrase IX/*antagonists & inhibitors
Carbonic Anhydrase Inhibitors/*pharmacology
Carbonic Anhydrases/*metabolism
Sulfonamides/*pharmacology
Antigens, Neoplasm/metabolism ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Carbonic Anhydrase IX/metabolism ; Carbonic Anhydrase Inhibitors/chemical synthesis ; Carbonic Anhydrase Inhibitors/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Molecular Structure ; Structure-Activity Relationship ; Sulfonamides/chemical synthesis ; Sulfonamides/chemistry

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Skocz do pozycji: 4.

Tytuł:: Immune Checkpoint Blockade via PD-L1 Potentiates More CD28-Based than 4-1BB-Based Anti-Carbonic Anhydrase IX Chimeric Antigen Receptor T Cells.
Autorzy:: de Campos NSP; Center for Natural and Human Sciences, Federal University of ABC, Santo Andre 09210-580, SP, Brazil.
de Oliveira Beserra A; A.C. Camargo Cancer Center, Centro Internacional de Pesquisa, Sao Paulo 01508-010, SP, Brazil.
Pereira PHB; A.C. Camargo Cancer Center, Centro Internacional de Pesquisa, Sao Paulo 01508-010, SP, Brazil.
Chaves AS; A.C. Camargo Cancer Center, Centro Internacional de Pesquisa, Sao Paulo 01508-010, SP, Brazil.
Fonseca FLA; Laboratório de Análises Clínicas, Centro Universitário Faculdade de Medicina do ABC, Santo Andre 09060-870, SP, Brazil.; Departamento de Ciências Farmacêuticas, Universidade Federal de Aso Paulo, Diadema 09920-000, SP, Brazil.
da Silva Medina T; A.C. Camargo Cancer Center, Centro Internacional de Pesquisa, Sao Paulo 01508-010, SP, Brazil.
Dos Santos TG; A.C. Camargo Cancer Center, Centro Internacional de Pesquisa, Sao Paulo 01508-010, SP, Brazil.
Wang Y; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02215, USA.
Marasco WA; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02215, USA.
Suarez ER; Center for Natural and Human Sciences, Federal University of ABC, Santo Andre 09210-580, SP, Brazil.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 May 13; Vol. 23 (10). Date of Electronic Publication: 2022 May 13.
Typ publikacji:: Journal Article
MeSH Terms:: B7-H1 Antigen*/antagonists & inhibitors
B7-H1 Antigen*/immunology
Carbonic Anhydrase IX*/immunology
Carcinoma, Renal Cell*/immunology
Carcinoma, Renal Cell*/pathology
Carcinoma, Renal Cell*/therapy
Kidney Neoplasms*/immunology
Kidney Neoplasms*/pathology
Kidney Neoplasms*/therapy
Receptors, Chimeric Antigen*/immunology
Animals ; Antibodies/immunology ; CD28 Antigens ; Immune Checkpoint Inhibitors ; Leukocytes, Mononuclear/pathology ; Mice ; T-Lymphocytes/immunology

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Skocz do pozycji: 5.

Tytuł:: Carbonic anhydrase IX-targeted H-APBC nanosystem combined with phototherapy facilitates the efficacy of PI3K/mTOR inhibitor and resists HIF-1α-dependent tumor hypoxia adaptation.
Autorzy:: Liu J; Breast Cancer Center, Shanghai East Hospital, Shanghai Key Laboratory of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Tongji University, Shanghai, 200092, People's Republic of China.
Hu X; Breast Cancer Center, Shanghai East Hospital, Shanghai Key Laboratory of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Tongji University, Shanghai, 200092, People's Republic of China.
Feng L; Breast Cancer Center, Shanghai East Hospital, Shanghai Key Laboratory of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Tongji University, Shanghai, 200092, People's Republic of China.
Lin Y; Breast Cancer Center, Shanghai East Hospital, Shanghai Key Laboratory of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Tongji University, Shanghai, 200092, People's Republic of China.
Liang S; Breast Cancer Center, Shanghai East Hospital, Shanghai Key Laboratory of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Tongji University, Shanghai, 200092, People's Republic of China.
Zhu Z; Breast Cancer Center, Shanghai East Hospital, Shanghai Key Laboratory of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Tongji University, Shanghai, 200092, People's Republic of China.
Shi S; Breast Cancer Center, Shanghai East Hospital, Shanghai Key Laboratory of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Tongji University, Shanghai, 200092, People's Republic of China. .
Dong C; Breast Cancer Center, Shanghai East Hospital, Shanghai Key Laboratory of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Tongji University, Shanghai, 200092, People's Republic of China. cy_.; Pokaż więcej
Źródło:: Journal of nanobiotechnology [J Nanobiotechnology] 2022 Apr 12; Vol. 20 (1), pp. 187. Date of Electronic Publication: 2022 Apr 12.
Typ publikacji:: Journal Article
MeSH Terms:: Breast Neoplasms*/drug therapy
Breast Neoplasms*/metabolism
Breast Neoplasms*/pathology
Carbonic Anhydrase IX*/antagonists & inhibitors
Nanoparticles*/administration & dosage
Phototherapy*
Quinolines*/pharmacology
TOR Serine-Threonine Kinases*/antagonists & inhibitors
TOR Serine-Threonine Kinases*/metabolism
Acidosis ; Cell Hypoxia ; Cell Line, Tumor ; Cell Proliferation ; Drug Delivery Systems ; Humans ; Imidazoles ; Molecular Targeted Therapy ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphoinositide-3 Kinase Inhibitors ; Tumor Hypoxia

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Skocz do pozycji: 6.

Tytuł:: Hypoxia Marker Carbonic Anhydrase IX Is Present in Abdominal Aortic Aneurysm Tissue and Plasma.
Autorzy:: Grossmannova K; Department of Cancer Biology, Institute of Virology, Biomedical Research Center, Slovak Academy of Sciences, Dúbravská Cesta 9, 84505 Bratislava, Slovakia.
Barathova M; Department of Cancer Biology, Institute of Virology, Biomedical Research Center, Slovak Academy of Sciences, Dúbravská Cesta 9, 84505 Bratislava, Slovakia.
Belvoncikova P; Department of Cancer Biology, Institute of Virology, Biomedical Research Center, Slovak Academy of Sciences, Dúbravská Cesta 9, 84505 Bratislava, Slovakia.
Lauko V; Department of Laboratory Medicine, National Institute of Cardiovascular Disease, Pod Krásnou Hôrkou 1, 83101 Bratislava, Slovakia.
Csaderova L; Department of Cancer Biology, Institute of Virology, Biomedical Research Center, Slovak Academy of Sciences, Dúbravská Cesta 9, 84505 Bratislava, Slovakia.
Tomka J; Department of Vascular Surgery, National Institute of Cardiovascular Disease, Pod Krásnou Hôrkou 1, 83101 Bratislava, Slovakia.
Dulka T; Department of Vascular Surgery, National Institute of Cardiovascular Disease, Pod Krásnou Hôrkou 1, 83101 Bratislava, Slovakia.
Pastorek J; MABPRO, a.s., Dúbravská Cesta 2, 84104 Bratislava, Slovakia.
Madaric J; Department of Angiology, National Institute of Cardiovascular Disease, Pod Krásnou Hôrkou 1, 83101 Bratislava, Slovakia.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2022 Jan 14; Vol. 23 (2). Date of Electronic Publication: 2022 Jan 14.
Typ publikacji:: Journal Article
MeSH Terms:: Biomarkers*
Aortic Aneurysm, Abdominal/*metabolism
Carbonic Anhydrase IX/*metabolism
Hypoxia/*metabolism
Aged ; Aged, 80 and over ; Aortic Aneurysm, Abdominal/diagnosis ; Aortic Aneurysm, Abdominal/etiology ; Aortic Aneurysm, Abdominal/therapy ; Carbonic Anhydrase IX/blood ; Carbonic Anhydrase IX/genetics ; Disease Susceptibility ; Female ; Gene Expression ; Gene Expression Profiling ; Humans ; Hypoxia/genetics ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Immunohistochemistry ; Male ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism

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Skocz do pozycji: 7.

Tytuł:: Anti-breast cancer action of carbonic anhydrase IX inhibitor 4-[4-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-benzylidene-hydrazinocarbonyl]-benzenesulfonamide (BSM-0004): in vitro and in vivo studies.
Autorzy:: Mishra CB; College of Pharmacy, Sookmyung Women's University, Seoul, Republic of Korea.
Mongre RK; Department of Biosystem, Molecular Cancer Biology Laboratory, Cellular Heterogeneity Research Center, Sookmyung Women's University, Seoul, Republic of Korea.
Prakash A; Amity Institute of Integrative Sciences and Health, Amity University, Gurgaon, India.
Jeon R; College of Pharmacy, Sookmyung Women's University, Seoul, Republic of Korea.
Supuran CT; Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche, Universitàdegli Studi di Firenze, Florence, Italy.
Lee MS; Department of Biosystem, Molecular Cancer Biology Laboratory, Cellular Heterogeneity Research Center, Sookmyung Women's University, Seoul, Republic of Korea.; Pokaż więcej
Źródło:: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 954-963.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents/*pharmacology
Breast Neoplasms/*drug therapy
Carbonic Anhydrase IX/*antagonists & inhibitors
Carbonic Anhydrase Inhibitors/*pharmacology
Animals ; Antigens, Neoplasm/metabolism ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Carbonic Anhydrase IX/metabolism ; Carbonic Anhydrase Inhibitors/chemical synthesis ; Carbonic Anhydrase Inhibitors/chemistry ; Cell Cycle Checkpoints/drug effects ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Female ; Humans ; Mammary Neoplasms, Experimental/drug therapy ; Mammary Neoplasms, Experimental/metabolism ; Mammary Neoplasms, Experimental/pathology ; Mice ; Mice, Nude ; Molecular Structure ; Structure-Activity Relationship ; Tumor Cells, Cultured

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Skocz do pozycji: 8.

Tytuł:: Synthesis, Molecular Docking Analysis, and Biological Evaluations of Saccharide-Modified Sulfonamides as Carbonic Anhydrase IX Inhibitors.
Autorzy:: Zhang Z; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
Yang H; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
Zhong Y; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
Wang Y; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
Wang J; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
Cheng M; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.
Liu Y; Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Dec 19; Vol. 22 (24). Date of Electronic Publication: 2021 Dec 19.
Typ publikacji:: Journal Article
MeSH Terms:: Carbonic Anhydrase IX/*antagonists & inhibitors
Carbonic Anhydrase Inhibitors/*chemistry
Carbonic Anhydrase Inhibitors/*pharmacology
Sulfonamides/*chemistry
Sulfonamides/*pharmacology
Antigens, Neoplasm/metabolism ; Carbonic Anhydrase IX/metabolism ; Carbonic Anhydrase Inhibitors/chemical synthesis ; Cell Line, Tumor ; HT29 Cells ; Humans ; Molecular Docking Simulation ; Protein Isoforms/antagonists & inhibitors ; Protein Isoforms/metabolism ; Sulfonamides/chemical synthesis

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Skocz do pozycji: 9.

Tytuł:: Selective inhibition of carbonic anhydrase IX and XII by coumarin and psoralen derivatives.
Autorzy:: Meleddu R; Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Italy.
Deplano S; Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Italy.
Maccioni E; Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Italy.
Ortuso F; Dipartimento di Scienze della Salute, Università Magna Graecia di Catanzaro, Catanzaro, Italy.
Cottiglia F; Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Italy.
Secci D; Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Italy.
Onali A; Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Italy.
Sanna E; Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Italy.
Angeli A; Dipartimento NEUROFARBA, Sezione di Scienze Farmaceutiche, Università degli Studi di Firenze, Sesto Fiorentino, Italy.
Angius R; Laboratorio NMR e Tecnologie Bioanalitiche, Sardegna Ricerche, Pula, Italy.
Alcaro S; Dipartimento di Scienze della Salute, Università Magna Graecia di Catanzaro, Catanzaro, Italy.
Supuran CT; Dipartimento NEUROFARBA, Sezione di Scienze Farmaceutiche, Università degli Studi di Firenze, Sesto Fiorentino, Italy.
Distinto S; Department of Life and Environmental Sciences, University of Cagliari, Monserrato, Italy.; Pokaż więcej
Źródło:: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 685-692.
Typ publikacji:: Journal Article
MeSH Terms:: Carbonic Anhydrase IX/*antagonists & inhibitors
Carbonic Anhydrase Inhibitors/*pharmacology
Carbonic Anhydrases/*metabolism
Coumarins/*pharmacology
Ficusin/*pharmacology
Antigens, Neoplasm/metabolism ; Carbonic Anhydrase IX/metabolism ; Carbonic Anhydrase Inhibitors/chemical synthesis ; Carbonic Anhydrase Inhibitors/chemistry ; Coumarins/chemical synthesis ; Coumarins/chemistry ; Dose-Response Relationship, Drug ; Ficusin/chemical synthesis ; Ficusin/chemistry ; Humans ; Models, Molecular ; Molecular Structure ; Structure-Activity Relationship

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Skocz do pozycji: 10.

Tytuł:: Vanillin enones as selective inhibitors of the cancer associated carbonic anhydrase isoforms IX and XII. The out of the active site pocket for the design of selective inhibitors?
Autorzy:: Riafrecha LE; CEDECOR (UNLP-CICBA), CONICET, Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina.
Le Pors MS; CEDECOR (UNLP-CICBA), CONICET, Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina.
Lavecchia MJ; CEQUINOR (CONICET-UNLP) Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina.
Bua S; Laboratorio di Chimica Bioinorganica, Universitá degli Studi di Firenze, Florence, Italy.
Supuran CT; Laboratorio di Chimica Bioinorganica, Universitá degli Studi di Firenze, Florence, Italy.; NEUROFARBA Department, Section of Pharmaceutical Chemistry, Università degli Studi di Firenze, Florence, Italy.
Colinas PA; CEDECOR (UNLP-CICBA), CONICET, Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina.; Pokaż więcej
Źródło:: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2021 Dec; Vol. 36 (1), pp. 2118-2127.
Typ publikacji:: Journal Article
MeSH Terms:: Drug Design*
Benzaldehydes/*pharmacology
Carbonic Anhydrase IX/*antagonists & inhibitors
Carbonic Anhydrase Inhibitors/*pharmacology
Carbonic Anhydrases/*metabolism
Antigens, Neoplasm/metabolism ; Benzaldehydes/chemical synthesis ; Benzaldehydes/chemistry ; Binding Sites/drug effects ; Carbonic Anhydrase IX/metabolism ; Carbonic Anhydrase Inhibitors/chemical synthesis ; Carbonic Anhydrase Inhibitors/chemistry ; Crystallography, X-Ray ; Dose-Response Relationship, Drug ; Humans ; Molecular Docking Simulation ; Molecular Structure ; Structure-Activity Relationship

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Skocz do pozycji: 11.

Tytuł:: Affinity Selections of DNA-Encoded Chemical Libraries on Carbonic Anhydrase IX-Expressing Tumor Cells Reveal a Dependence on Ligand Valence.
Autorzy:: Oehler S; Department of Chemistry and Applied Biosciences ETH Zürich, Vladimir-Prelog-Weg 3, 8093, Zürich, Switzerland.
Catalano M; Department of Chemistry and Applied Biosciences ETH Zürich, Vladimir-Prelog-Weg 3, 8093, Zürich, Switzerland.
Scapozza I; Department of Chemistry and Applied Biosciences ETH Zürich, Vladimir-Prelog-Weg 3, 8093, Zürich, Switzerland.
Bigatti M; Philochem AG, Libernstrasse 3, 8112, Otelfingen, Switzerland.
Bassi G; Department of Chemistry and Applied Biosciences ETH Zürich, Vladimir-Prelog-Weg 3, 8093, Zürich, Switzerland.
Favalli N; Department of Chemistry and Applied Biosciences ETH Zürich, Vladimir-Prelog-Weg 3, 8093, Zürich, Switzerland.
Mortensen MR; Department of Chemistry and Applied Biosciences ETH Zürich, Vladimir-Prelog-Weg 3, 8093, Zürich, Switzerland.
Samain F; Philochem AG, Libernstrasse 3, 8112, Otelfingen, Switzerland.
Scheuermann J; Department of Chemistry and Applied Biosciences ETH Zürich, Vladimir-Prelog-Weg 3, 8093, Zürich, Switzerland.
Neri D; Philochem AG, Libernstrasse 3, 8112, Otelfingen, Switzerland.; Pokaż więcej
Źródło:: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2021 Jun 21; Vol. 27 (35), pp. 8985-8993. Date of Electronic Publication: 2021 May 18.
Typ publikacji:: Journal Article
MeSH Terms:: Carbonic Anhydrase IX*/genetics
DNA*
Small Molecule Libraries*
Antigens, Neoplasm/genetics ; Cell Line, Tumor ; Gene Library ; Humans ; Ligands

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Skocz do pozycji: 12.

Tytuł:: Process validation, current good manufacturing practice production, dosimetry, and toxicity studies of the carbonic anhydrase IX imaging agent [ In]In-XYIMSR-01 for phase I regulatory approval.
Autorzy:: De Silva RA; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Gorin MA; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Mease RC; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Minn I; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Lisok A; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Plyku D; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Nimmagadda S; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Allaf ME; The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Yang X; Peking University First Hospital, Beijing, China.
Sgouros G; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Rowe SP; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Pomper MG; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.; Pokaż więcej
Źródło:: Journal of labelled compounds & radiopharmaceuticals [J Labelled Comp Radiopharm] 2021 May 30; Vol. 64 (6), pp. 243-250. Date of Electronic Publication: 2021 Mar 04.
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Antigens, Neoplasm*
Carbonic Anhydrase IX*

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Skocz do pozycji: 13.

Tytuł:: Factors, associated with elevated concentration of soluble carbonic anhydrase IX in plasma of women with cervical dysplasia.
Autorzy:: Grincevičienė Š; Department of Biothermodynamics and Drug Design, Institute of Biotechnology, Life Sciences Center, Vilnius University, Sauletekio sl. 7, 10257, Vilnius, Lithuania. .
Vaitkienė D; Department of Obstetrics and Gynecology, Medical Academy, Lithuanian University of Health Sciences, Eiveniu st. 2, 50161, Kaunas, Lithuania.
Kanopienė D; Consultative Polyclinic Department, National Cancer Institute, Santariskiu st. 1, 08406, Vilnius, Lithuania.
Vansevičiūtė R; Consultative Polyclinic Department, National Cancer Institute, Santariskiu st. 1, 08406, Vilnius, Lithuania.; Clinic of Obstetrics and Gynecology, Faculty of Medicine, Institute of Clinical Medicine, Vilnius University, M. K. Ciurlionio st. 21, 03101, Vilnius, Lithuania.
Tykvart J; Diana Biotechnologies, Nad Safinou II 366, 252 50, Vestec, Czech Republic.
Sukovas A; Department of Obstetrics and Gynecology, Medical Academy, Lithuanian University of Health Sciences, Eiveniu st. 2, 50161, Kaunas, Lithuania.
Celiešiūtė J; Department of Obstetrics and Gynecology, Medical Academy, Lithuanian University of Health Sciences, Eiveniu st. 2, 50161, Kaunas, Lithuania.
Ivanauskaitė Didžiokienė E; National Center of Pathology, Affiliate of Vilnius University Hospital Santaros Klinikos, P. Baublio st. 5, 08406, Vilnius, Lithuania.
Čižauskas A; Department of Pathological Anatomy, Medical Academy, Lithuanian University of Health Sciences, Eiveniu st. 2, 50161, Kaunas, Lithuania.
Laurinavičienė A; National Center of Pathology, Affiliate of Vilnius University Hospital Santaros Klinikos, P. Baublio st. 5, 08406, Vilnius, Lithuania.; Department of Pathology, Forensic Medicine and Pharmacology, Institute of Biomedical Science, Faculty of Medicine, Vilnius University, M. K. Ciurlionio st. 21, 03101, Vilnius, Lithuania.
Král V; Institute of Molecular Genetics of the Czech Academy of Sciences, Flemingovo n. 2, 166 37, Prague 6, Czech Republic.
Hlavačková A; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo náměstí 542/2, 160 00, Praha, Czech Republic.
Zemanová J; Diana Biotechnologies, Nad Safinou II 366, 252 50, Vestec, Czech Republic.
Stravinskienė D; Department of Immunology and Cell Biology, Institute of Biotechnology, Life Sciences Center, Vilnius University, Sauletekio sl. 7, 10257, Vilnius, Lithuania.
Sližienė A; Department of Immunology and Cell Biology, Institute of Biotechnology, Life Sciences Center, Vilnius University, Sauletekio sl. 7, 10257, Vilnius, Lithuania.
Petrošiūtė A; Department of Biothermodynamics and Drug Design, Institute of Biotechnology, Life Sciences Center, Vilnius University, Sauletekio sl. 7, 10257, Vilnius, Lithuania.
Petrauskas V; Department of Biothermodynamics and Drug Design, Institute of Biotechnology, Life Sciences Center, Vilnius University, Sauletekio sl. 7, 10257, Vilnius, Lithuania.
Balsytė R; Department of Biothermodynamics and Drug Design, Institute of Biotechnology, Life Sciences Center, Vilnius University, Sauletekio sl. 7, 10257, Vilnius, Lithuania.
Grincevičius J; Pharmacy Center, Institute of Biomedical Science, Faculty of Medicine, Vilnius University, M. K. Ciurlionio st. 21, 03101, Vilnius, Lithuania.
Navratil V; Diana Biotechnologies, Nad Safinou II 366, 252 50, Vestec, Czech Republic.
Jahn U; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo náměstí 542/2, 160 00, Praha, Czech Republic.
Konvalinka J; Diana Biotechnologies, Nad Safinou II 366, 252 50, Vestec, Czech Republic.; Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo náměstí 542/2, 160 00, Praha, Czech Republic.
Žvirblienė A; Department of Immunology and Cell Biology, Institute of Biotechnology, Life Sciences Center, Vilnius University, Sauletekio sl. 7, 10257, Vilnius, Lithuania.
Matulis D; Department of Biothermodynamics and Drug Design, Institute of Biotechnology, Life Sciences Center, Vilnius University, Sauletekio sl. 7, 10257, Vilnius, Lithuania.
Matulienė J; Department of Biothermodynamics and Drug Design, Institute of Biotechnology, Life Sciences Center, Vilnius University, Sauletekio sl. 7, 10257, Vilnius, Lithuania.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2022 Sep 13; Vol. 12 (1), pp. 15397. Date of Electronic Publication: 2022 Sep 13.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Carbonic Anhydrases*
Uterine Cervical Neoplasms*
Uterine Cervical Dysplasia*
Antigens, Neoplasm/*metabolism
Carbonic Anhydrase IX/*metabolism
Aged ; Female ; Humans

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Skocz do pozycji: 14.

Tytuł:: Inhibition of Carbonic Anhydrase IX Promotes Apoptosis through Intracellular pH Level Alterations in Cervical Cancer Cells.
Autorzy:: Temiz E; Program of Medical Promotion and Marketing, Health Services Vocational School, Harran University, Sanliurfa 63300, Turkey.
Koyuncu I; Department of Medical Biochemistry, Faculty of Medicine, Harran University, Sanliurfa 63290, Turkey.
Durgun M; Department of Chemistry, Faculty of Arts and Sciences, Harran University, Sanliurfa 63290, Turkey.
Caglayan M; Department of Medical Biochemistry, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara 06110, Turkey.
Gonel A; Department of Medical Biochemistry, Faculty of Medicine, Harran University, Sanliurfa 63290, Turkey.
Güler EM; Department of Medical Biochemistry, Faculty of Hamidiye Medicine, University of Health Sciences Turkey, Istanbul 34668, Turkey.
Kocyigit A; Department of Medical Biochemistry, Faculty of Medicine, Bezmialem Vakif University, Istanbul 34093, Turkey.
Supuran CT; NEUROFARBA Department, Section of Pharmaceutical and Nutriceutical Sciences, Università degli Studi di Firenze, Sesto Fiorentino, 50019 Florence, Italy.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2021 Jun 05; Vol. 22 (11). Date of Electronic Publication: 2021 Jun 05.
Typ publikacji:: Journal Article
MeSH Terms:: Carbonic Anhydrase IX/*genetics
Carbonic Anhydrase Inhibitors/*pharmacology
Cell Proliferation/*drug effects
Uterine Cervical Neoplasms/*drug therapy
Apoptosis/drug effects ; Carbonic Anhydrase IX/antagonists & inhibitors ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; HeLa Cells ; Humans ; Membrane Potential, Mitochondrial/drug effects ; Phenylurea Compounds/pharmacology ; Reactive Oxygen Species/metabolism ; Sulfonamides/pharmacology ; Uterine Cervical Neoplasms/genetics ; Uterine Cervical Neoplasms/pathology

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Skocz do pozycji: 15.

Tytuł:: Cobalt Bis(dicarbollide) Alkylsulfonamides: Potent and Highly Selective Inhibitors of Tumor Specific Carbonic Anhydrase IX.
Autorzy:: Grüner B; Department of Synthesis, Institute of Inorganic Chemistry of the Czech Academy of Sciences, 250 68, Řež, Czech Republic.
Kugler M; Institute of Molecular Genetics of the Czech Academy of Sciences, Vídeňská 1083, 142 20, Prague 4, Czech Republic.; Institute of Organic Chemistry and, Biochemistry of the Czech Academy of Sciences, Flemingovo nám. 2, 166 10 Prague, Czech Republic.
El Anwar S; Department of Synthesis, Institute of Inorganic Chemistry of the Czech Academy of Sciences, 250 68, Řež, Czech Republic.
Holub J; Department of Synthesis, Institute of Inorganic Chemistry of the Czech Academy of Sciences, 250 68, Řež, Czech Republic.
Nekvinda J; Department of Synthesis, Institute of Inorganic Chemistry of the Czech Academy of Sciences, 250 68, Řež, Czech Republic.
Bavol D; Department of Synthesis, Institute of Inorganic Chemistry of the Czech Academy of Sciences, 250 68, Řež, Czech Republic.
Růžičková Z; Department of General and Inorganic Chemistry, Faculty of Chemical Technology, University of Pardubice, Studentská 573, 532 10, Pardubice, Czech Republic.
Pospíšilová K; Institute of Organic Chemistry and, Biochemistry of the Czech Academy of Sciences, Flemingovo nám. 2, 166 10 Prague, Czech Republic.
Fábry M; Institute of Molecular Genetics of the Czech Academy of Sciences, Vídeňská 1083, 142 20, Prague 4, Czech Republic.
Král V; Institute of Molecular Genetics of the Czech Academy of Sciences, Vídeňská 1083, 142 20, Prague 4, Czech Republic.
Brynda J; Institute of Molecular Genetics of the Czech Academy of Sciences, Vídeňská 1083, 142 20, Prague 4, Czech Republic.
Řezáčová P; Institute of Organic Chemistry and, Biochemistry of the Czech Academy of Sciences, Flemingovo nám. 2, 166 10 Prague, Czech Republic.; Pokaż więcej
Źródło:: ChemPlusChem [Chempluschem] 2021 Mar; Vol. 86 (3), pp. 352-363. Date of Electronic Publication: 2020 Sep 21.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Carbonic Anhydrase IX/*antagonists & inhibitors
Carbonic Anhydrase Inhibitors/*chemistry
Cobalt/*chemistry
Coordination Complexes/*chemistry
Sulfonamides/*chemistry
Binding Sites ; Carbonic Anhydrase IX/metabolism ; Carbonic Anhydrase Inhibitors/metabolism ; Carbonic Anhydrase Inhibitors/therapeutic use ; Catalytic Domain ; Coordination Complexes/metabolism ; Coordination Complexes/therapeutic use ; Crystallography, X-Ray ; Humans ; Molecular Conformation ; Molecular Docking Simulation ; Neoplasms/drug therapy ; Neoplasms/pathology

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Skocz do pozycji: 16.

Tytuł:: Development of a Ga-labelled PET tracer for carbonic anhydrase IX-overexpressed tumors using the artificial sweetener saccharin.
Autorzy:: Shin UC; School of Health and Environmental Science, College of Health Science, Korea University, Seoul, South Korea.
Choi JS; School of Health and Environmental Science, College of Health Science, Korea University, Seoul, South Korea.
Beak YJ; School of Health and Environmental Science, College of Health Science, Korea University, Seoul, South Korea.
Lee MW; School of Health and Environmental Science, College of Health Science, Korea University, Seoul, South Korea.
Kim HS; Health Science Research Center, Korea University, Seoul, South Korea.
Choi DW; School of Health and Environmental Science, College of Health Science, Korea University, Seoul, South Korea.
Kim DG; Kyung-In Synthetic Corporation, Seoul, South Korea.
Kim SW; School of Health and Environmental Science, College of Health Science, Korea University, Seoul, South Korea.; Transdisciplinary Major in Learning Health Systems, Graduate School, Korea University, Seoul, South Korea.; Pokaż więcej
Źródło:: Journal of labelled compounds & radiopharmaceuticals [J Labelled Comp Radiopharm] 2021 Mar; Vol. 64 (3), pp. 129-139. Date of Electronic Publication: 2020 Nov 09.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Antigens, Neoplasm*
Carbonic Anhydrase IX*

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Skocz do pozycji: 17.

Tytuł:: PET imaging and pharmacological therapy targeting carbonic anhydrase-IX high-expressing tumors using US2 platform based on bivalent ureidosulfonamide.
Autorzy:: Iikuni S; Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
Watanabe H; Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
Shimizu Y; Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.; Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Nakamoto Y; Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Ono M; Department of Patho-Functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2020 Dec 09; Vol. 15 (12), pp. e0243327. Date of Electronic Publication: 2020 Dec 09 (Print Publication: 2020).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Antigens, Neoplasm*/metabolism
Carbonic Anhydrase IX*/antagonists & inhibitors
Carbonic Anhydrase IX*/metabolism
Carbonic Anhydrase Inhibitors*/chemistry
Carbonic Anhydrase Inhibitors*/pharmacokinetics
Carbonic Anhydrase Inhibitors*/pharmacology
Neoplasm Proteins*/antagonists & inhibitors
Neoplasm Proteins*/metabolism
Neoplasms, Experimental*/diagnostic imaging
Neoplasms, Experimental*/drug therapy
Neoplasms, Experimental*/enzymology
Positron-Emission Tomography*
Yttrium Radioisotopes*/chemistry
Yttrium Radioisotopes*/pharmacokinetics
Yttrium Radioisotopes*/pharmacology
Animals ; HT29 Cells ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Xenograft Model Antitumor Assays

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Skocz do pozycji: 18.

Tytuł:: A potentiated cooperation of carbonic anhydrase IX and histone deacetylase inhibitors against cancer.
Autorzy:: Ruzzolini J; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Florence, Italy.
Laurenzana A; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Florence, Italy.
Andreucci E; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Florence, Italy.
Peppicelli S; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Florence, Italy.
Bianchini F; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Florence, Italy.
Carta F; Department of NEUROFARBA, University of Florence, Florence, Italy.
Supuran CT; Department of NEUROFARBA, University of Florence, Florence, Italy.
Romanelli MN; Department of NEUROFARBA, University of Florence, Florence, Italy.
Nediani C; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Florence, Italy.
Calorini L; Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', University of Florence, Florence, Italy.; Center of Excellence for Research, Transfer and High Education, DenoTHE University of Florence, Florence, Italy.; Pokaż więcej
Źródło:: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 391-397.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents/*pharmacology
Carbonic Anhydrase IX/*antagonists & inhibitors
Carbonic Anhydrase Inhibitors/*pharmacology
Histone Deacetylase Inhibitors/*pharmacology
Histone Deacetylases/*metabolism
Phenylurea Compounds/*pharmacology
Sulfonamides/*pharmacology
Antigens, Neoplasm/metabolism ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Carbonic Anhydrase IX/metabolism ; Carbonic Anhydrase Inhibitors/chemical synthesis ; Carbonic Anhydrase Inhibitors/chemistry ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Histone Deacetylase Inhibitors/chemical synthesis ; Histone Deacetylase Inhibitors/chemistry ; Humans ; Molecular Structure ; Phenylurea Compounds/chemical synthesis ; Phenylurea Compounds/chemistry ; Structure-Activity Relationship ; Sulfonamides/chemical synthesis ; Sulfonamides/chemistry ; Tumor Cells, Cultured

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Skocz do pozycji: 19.

Tytuł:: The structural basis for the selectivity of sulfonamido dicarbaboranes toward cancer-associated carbonic anhydrase IX.
Autorzy:: Kugler M; Deparment of Structural Biology, Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.; Deparment of Structural Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Holub J; Department of Syntheses, Institute of Inorganic Chemistry of the Czech Academy of Sciences, Řež, Czech Republic.
Brynda J; Deparment of Structural Biology, Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.; Deparment of Structural Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Pospíšilová K; Deparment of Structural Biology, Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.
Anwar SE; Department of Syntheses, Institute of Inorganic Chemistry of the Czech Academy of Sciences, Řež, Czech Republic.
Bavol D; Department of Syntheses, Institute of Inorganic Chemistry of the Czech Academy of Sciences, Řež, Czech Republic.
Havránek M; Chemistry Department, Apigenex, s.r.o., Prague, Czech Republic.
Král V; Deparment of Structural Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Fábry M; Deparment of Structural Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Grüner B; Department of Syntheses, Institute of Inorganic Chemistry of the Czech Academy of Sciences, Řež, Czech Republic.
Řezáčová P; Deparment of Structural Biology, Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.; Deparment of Structural Biology, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.; Pokaż więcej
Źródło:: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 1800-1810.
Typ publikacji:: Journal Article
MeSH Terms:: Antineoplastic Agents/*chemistry
Boron Compounds/*chemistry
Carbonic Anhydrase IX/*antagonists & inhibitors
Carbonic Anhydrase Inhibitors/*chemistry
Sulfonamides/*chemistry
Amino Acid Sequence ; Antigens, Neoplasm/genetics ; Antineoplastic Agents/pharmacology ; Carbonic Anhydrase IX/genetics ; Carbonic Anhydrase Inhibitors/pharmacology ; Catalytic Domain ; Crystallography, X-Ray ; Drug Screening Assays, Antitumor ; HEK293 Cells ; Humans ; Hydrophobic and Hydrophilic Interactions ; Protein Binding ; Structure-Activity Relationship ; Sulfonamides/pharmacology

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Skocz do pozycji: 20.

Tytuł:: Plasmatic exosomes from prostate cancer patients show increased carbonic anhydrase IX expression and activity and low pH.
Autorzy:: Logozzi M; Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.
Mizzoni D; Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.
Capasso C; National Research Council, Institute of Biosciences and BioResources, Naples, Italy.
Del Prete S; National Research Council, Institute of Biosciences and BioResources, Naples, Italy.
Di Raimo R; Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.
Falchi M; National AIDS Center, Istituto Superiore di Sanità, Rome, Italy.
Angelini DF; Neuroimmunology Unit, IRCCS Santa Lucia Foundation, Rome, Italy.
Sciarra A; Department of Urology, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
Maggi M; Department of Urology, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
Supuran CT; NEUROFARBA Department, University of Florence, Section of Pharmaceutical Chemistry, Florence, Italy.
Fais S; Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.; Pokaż więcej
Źródło:: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 280-288.
Typ publikacji:: Journal Article
MeSH Terms:: Antigens, Neoplasm/*biosynthesis
Carbonic Anhydrase IX/*biosynthesis
Exosomes/*metabolism
Prostatic Neoplasms/*blood
Aged ; Antigens, Neoplasm/blood ; Carbonic Anhydrase IX/blood ; Cell Line ; Humans ; Hydrogen-Ion Concentration ; Male ; Microscopy, Confocal ; Middle Aged

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