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Wyszukujesz frazę ""Carcinogenesis"" wg kryterium: Temat


Tytuł:
Valproic acid counteracts polycyclic aromatic hydrocarbons (PAHs)-induced tumorigenic effects by regulating the polarization of macrophages.
Autorzy:
Zhang Y; Department of Occupational Health and Occupational Medicine, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China.
Lim D; Translational Health Research Institute, School of Health Sciences, Western Sydney University, Campbelltown, New South Wales, Australia; College of Medicine and Public Health, Flinders University, Bedford Park, South Australia, Australia.
Cai Z; Department of Occupational Health and Occupational Medicine, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China.
Peng J; Department of Occupational Health and Occupational Medicine, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China.
Jia B; Department of Occupational Health and Occupational Medicine, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China.
Chu G; Department of Occupational Health and Occupational Medicine, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China.
Zhang F; Department of Occupational Health and Occupational Medicine, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China.
Dong C; Department of Occupational Health and Occupational Medicine, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China. Electronic address: .
Feng Z; Department of Occupational Health and Occupational Medicine, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, Shandong, China. Electronic address: .
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Źródło:
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2022 Aug; Vol. 241, pp. 113779. Date of Electronic Publication: 2022 Jun 22.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinogenesis*/drug effects
Carcinogenesis*/metabolism
Macrophages*/cytology
Macrophages*/pathology
Polycyclic Aromatic Hydrocarbons*/metabolism
Polycyclic Aromatic Hydrocarbons*/toxicity
Valproic Acid*/metabolism
Valproic Acid*/pharmacology
CD8-Positive T-Lymphocytes/metabolism ; Carcinogens/metabolism ; Cytokines/metabolism ; Endothelial Cells/metabolism ; Humans ; Neoplasms ; Tumor Microenvironment
Czasopismo naukowe
Tytuł:
Potential Mechanisms by which Glucocorticoids Induce Breast Carcinogenesis through Nrf2 Inhibition.
Autorzy:
Giudice A; Animal Facility, Istituto Nazionale Tumori - 'Fondazione G. Pascale' - IRCCS, 80131 Naples, Italy.
Aliberti SM; Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, 84081 Salerno, Italy.
Barbieri A; Animal Facility, Istituto Nazionale Tumori - 'Fondazione G. Pascale' - IRCCS, 80131 Naples, Italy.
Pentangelo P; Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, 84081 Salerno, Italy.
Bisogno I; Department of Radiological, Oncological and Anatomo-Pathological Science, University of Rome 'Sapienza', 00161 Rome, Italy.
D'Arena G; Hematology Service, San Luca Hospital, ASL Salerno, 84124 Salerno, Italy.
Cianciola E; Anesthesia and Intensive Care Unit, 'Immacolata di Sapri' Hospital- ASL Salerno, 84073 Salerno, Italy.
Caraglia M; Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', 80138 Naples, Italy.
Capunzo M; Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', University of Salerno, 84081 Salerno, Italy.
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Źródło:
Frontiers in bioscience (Landmark edition) [Front Biosci (Landmark Ed)] 2022 Jul 14; Vol. 27 (7), pp. 223.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Breast Neoplasms*/chemically induced
Carcinogenesis*/chemically induced
Glucocorticoids*/adverse effects
NF-E2-Related Factor 2*/antagonists & inhibitors
NF-E2-Related Factor 2*/genetics
Antioxidants/pharmacology ; Female ; Humans ; Hydrocortisone ; Oxidative Stress
Czasopismo naukowe
Tytuł:
PAX8 in the Junction between Development and Tumorigenesis.
Autorzy:
Kakun RR; Bruce and Ruth Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 3109601, Israel.; Clinical Research Institute at Rambam, Rambam Health Care Campus, Haifa 3109601, Israel.
Melamed Z; Division of Oncology, Rambam Health Care Campus, Haifa 3109601, Israel.
Perets R; Bruce and Ruth Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 3109601, Israel.; Clinical Research Institute at Rambam, Rambam Health Care Campus, Haifa 3109601, Israel.; Division of Oncology, Rambam Health Care Campus, Haifa 3109601, Israel.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2022 Jul 03; Vol. 23 (13). Date of Electronic Publication: 2022 Jul 03.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Carcinogenesis*/genetics
Carcinogenesis*/metabolism
Paired Box Transcription Factors*/metabolism
Female ; Humans ; Kidney ; Male ; PAX8 Transcription Factor/genetics ; PAX8 Transcription Factor/metabolism ; Thyroid Gland/metabolism
Czasopismo naukowe
Tytuł:
Alternative splicing of Apoptosis Stimulating Protein of TP53-2 (ASPP2) results in an oncogenic isoform promoting migration and therapy resistance in soft tissue sarcoma (STS).
Autorzy:
Tsintari V; Department of Hematology, Oncology, Clinical Immunology and Rheumatology, University Hospital Tübingen (UKT), Tübingen, Germany.
Walter B; Department of Hematology, Oncology, Clinical Immunology and Rheumatology, University Hospital Tübingen (UKT), Tübingen, Germany.
Fend F; Institute of Pathology, University Hospital Tübingen, Tübingen, Germany.
Overkamp M; Institute of Pathology, University Hospital Tübingen, Tübingen, Germany.
Rothermundt C; Department of Medical Oncology and Hematology, Cantonal Hospital St. Gallen (KSSG), St. Gallen, Switzerland.
Lopez CD; Department of Hematology and Medical Oncology, Oregon Health and Science University (OHSU), Portland, OR, USA.
Schittenhelm MM; Department of Medical Oncology and Hematology, Cantonal Hospital St. Gallen (KSSG), St. Gallen, Switzerland.
Kampa-Schittenhelm KM; Department of Hematology, Oncology, Clinical Immunology and Rheumatology, University Hospital Tübingen (UKT), Tübingen, Germany. .; Laboratory of Translational Experimental Hematology and Oncology, Medical Research Center and Department of Medical Oncology and Hematology, Cantonal Hospital, Rorschacherstr. 95, St. Gallen, 9007, Switzerland, St.Gallen. .; St. Gallen, Switzerland. .
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Źródło:
BMC cancer [BMC Cancer] 2022 Jul 02; Vol. 22 (1), pp. 725. Date of Electronic Publication: 2022 Jul 02.
Typ publikacji:
Journal Article
MeSH Terms:
Apoptosis Regulatory Proteins*/genetics
Apoptosis Regulatory Proteins*/metabolism
Carcinogenesis*/genetics
Carcinogenesis*/metabolism
Rhabdomyosarcoma*/genetics
Rhabdomyosarcoma*/metabolism
Sarcoma*/genetics
Sarcoma*/metabolism
Soft Tissue Neoplasms*/genetics
Soft Tissue Neoplasms*/metabolism
Alternative Splicing ; Apoptosis/genetics ; Drug Resistance, Neoplasm/genetics ; Drug Resistance, Neoplasm/physiology ; Humans ; Protein Isoforms/metabolism ; RNA, Messenger/metabolism ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism
Czasopismo naukowe
Tytuł:
Fundamental immune-oncogenicity trade-offs define driver mutation fitness.
Autorzy:
Hoyos D; Computational Oncology, Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Zappasodi R; Swim Across America Laboratory and Ludwig Collaborative, Immunology Program, Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY, USA. .; Department of Medicine, Weill Cornell Medical College, New York, NY, USA. .; Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY, USA. .; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY, USA. .
Schulze I; Swim Across America Laboratory and Ludwig Collaborative, Immunology Program, Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Sethna Z; Computational Oncology, Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
de Andrade KC; Division of Cancer Epidemiology and Genetics, Clinical Genetics Branch, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Bajorin DF; Department of Medicine, Weill Cornell Medical College, New York, NY, USA.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Bandlamudi C; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Callahan MK; Department of Medicine, Weill Cornell Medical College, New York, NY, USA.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Funt SA; Department of Medicine, Weill Cornell Medical College, New York, NY, USA.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Hadrup SR; Experimental and Translational Immunology, Health Technology, Technical University of Denmark, Lyngby, Denmark.
Holm JS; Experimental and Translational Immunology, Health Technology, Technical University of Denmark, Lyngby, Denmark.
Rosenberg JE; Department of Medicine, Weill Cornell Medical College, New York, NY, USA.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Shah SP; Computational Oncology, Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Physiology, Biophysics & Systems Biology, Weill Cornell Medicine, Weill Cornell Medical College, New York, NY, USA.
Vázquez-García I; Computational Oncology, Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Weigelt B; Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Wu M; Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Zamarin D; Swim Across America Laboratory and Ludwig Collaborative, Immunology Program, Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY, USA.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Campitelli LF; Adaptive Biotechnologies, Seattle, WA, USA.
Osborne EJ; Adaptive Biotechnologies, Seattle, WA, USA.
Klinger M; Adaptive Biotechnologies, Seattle, WA, USA.
Robins HS; Adaptive Biotechnologies, Seattle, WA, USA.
Khincha PP; Division of Cancer Epidemiology and Genetics, Clinical Genetics Branch, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Savage SA; Division of Cancer Epidemiology and Genetics, Clinical Genetics Branch, National Cancer Institute, National Institutes of Health, Rockville, MD, USA.
Balachandran VP; Department of Medicine, Weill Cornell Medical College, New York, NY, USA.; Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; David M. Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Wolchok JD; Swim Across America Laboratory and Ludwig Collaborative, Immunology Program, Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY, USA.; Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Hellmann MD; Department of Medicine, Weill Cornell Medical College, New York, NY, USA.; Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Thoracic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Merghoub T; Swim Across America Laboratory and Ludwig Collaborative, Immunology Program, Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY, USA. .; Department of Medicine, Weill Cornell Medical College, New York, NY, USA. .; Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY, USA. .; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. .
Levine AJ; Simons Center for Systems Biology, Institute for Advanced Study, Princeton, NJ, USA.
Łuksza M; Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Greenbaum BD; Computational Oncology, Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA. .; Physiology, Biophysics & Systems Biology, Weill Cornell Medicine, Weill Cornell Medical College, New York, NY, USA. .
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Źródło:
Nature [Nature] 2022 Jun; Vol. 606 (7912), pp. 172-179. Date of Electronic Publication: 2022 May 11.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinogenesis*/genetics
Carcinogenesis*/immunology
Evolution, Molecular*
Lung Neoplasms*/genetics
Lung Neoplasms*/therapy
Mutation*/genetics
Datasets as Topic ; Genes, p53 ; Genetic Fitness ; Genomics ; Healthy Volunteers ; Humans ; Immunotherapy ; Mutation, Missense ; Reproducibility of Results
Czasopismo naukowe
Tytuł:
Pan-Cancer Analysis of B4GALNT1 as a Potential Prognostic and Immunological Biomarker.
Autorzy:
Yi H; Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Lin Y; Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Li Y; Peking University Health Science Center, Peking University, Beijing 100191, China.
Guo Y; Peking University Health Science Center, Peking University, Beijing 100191, China.
Yuan L; Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Mao Y; Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
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Źródło:
Journal of immunology research [J Immunol Res] 2022 Jul 28; Vol. 2022, pp. 4355890. Date of Electronic Publication: 2022 Jul 28 (Print Publication: 2022).
Typ publikacji:
Journal Article
MeSH Terms:
Carcinogenesis*
Gangliosides*/metabolism
Biomarkers ; Cell Line, Tumor ; Cell Transformation, Neoplastic ; Humans ; Prognosis
Czasopismo naukowe
Tytuł:
The Role of DACT Family Members in Tumorigenesis and Tumor Progression.
Autorzy:
Zeng Y; Department of Neurosurgery, Guizhou Provincial People's Hospital, Guiyang, China.
Zhang J; Department of Anesthesiology, Guizhou Provincial People's Hospital, Guiyang, China.
Yue J; Department of Neurosurgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Han G; Department of Neurosurgery, Guizhou Provincial People's Hospital, Guiyang, China.
Liu W; Department of Respiratory and Critical Care Medicine, Guizhou Provincial People's Hospital, Guiyang, China.
Liu L; Department of Respiratory and Critical Care Medicine, Guizhou Provincial People's Hospital, Guiyang, China.
Lin X; Department of Nephrology, Guizhou Provincial People's Hospital, Guiyang, China.
Zha Y; Department of Nephrology, Guizhou Provincial People's Hospital, Guiyang, China.
Liu J; Department of Neurosurgery, Guizhou Provincial People's Hospital, Guiyang, China.
Tan Y; Department of Neurosurgery, Guizhou Provincial People's Hospital, Guiyang, China.
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Źródło:
International journal of biological sciences [Int J Biol Sci] 2022 Jul 11; Vol. 18 (11), pp. 4532-4544. Date of Electronic Publication: 2022 Jul 11 (Print Publication: 2022).
Typ publikacji:
Journal Article; Review
MeSH Terms:
Biomarkers, Tumor*
Carcinogenesis*/genetics
Cell Differentiation ; Cell Proliferation/genetics ; Humans
Czasopismo naukowe
Tytuł:
Oncogenic chimeric transcription factors drive tumor-specific transcription, processing, and translation of silent genomic regions.
Autorzy:
Vibert J; INSERM U830, Équipe Labellisée LNCC, Diversity and Plasticity of Childhood Tumors Lab, PSL Research University, SIREDO Oncology Center, Institut Curie Research Center, Paris, France; INSERM U830, Integrative Functional Genomics of Cancer Lab, PSL Research University, Institut Curie Research Center, Paris, France; Department of Translational Research, PSL Research University, Institut Curie Research Center, Paris, France.
Saulnier O; INSERM U830, Équipe Labellisée LNCC, Diversity and Plasticity of Childhood Tumors Lab, PSL Research University, SIREDO Oncology Center, Institut Curie Research Center, Paris, France.
Collin C; INSERM U830, Équipe Labellisée LNCC, Diversity and Plasticity of Childhood Tumors Lab, PSL Research University, SIREDO Oncology Center, Institut Curie Research Center, Paris, France.
Petit F; INSERM U830, Équipe Labellisée LNCC, Diversity and Plasticity of Childhood Tumors Lab, PSL Research University, SIREDO Oncology Center, Institut Curie Research Center, Paris, France.
Borgman KJE; Institut Curie, PSL Research University, Sorbonne Université, CNRS UMR 3664, Laboratoire Dynamique du Noyau, 75005 Paris, France; Institut Curie, PSL Research University, Sorbonne Université, CNRS UMR168, Laboratoire Physico Chimie Curie, 75005 Paris, France.
Vigneau J; INSERM U830, Équipe Labellisée LNCC, Diversity and Plasticity of Childhood Tumors Lab, PSL Research University, SIREDO Oncology Center, Institut Curie Research Center, Paris, France.
Gautier M; INSERM U830, Équipe Labellisée LNCC, Diversity and Plasticity of Childhood Tumors Lab, PSL Research University, SIREDO Oncology Center, Institut Curie Research Center, Paris, France.
Zaidi S; INSERM U830, Équipe Labellisée LNCC, Diversity and Plasticity of Childhood Tumors Lab, PSL Research University, SIREDO Oncology Center, Institut Curie Research Center, Paris, France.
Pierron G; Unité de Génétique Somatique, Service d'oncogénétique, Institut Curie, Centre Hospitalier, Paris, France.
Watson S; INSERM U830, Équipe Labellisée LNCC, Diversity and Plasticity of Childhood Tumors Lab, PSL Research University, SIREDO Oncology Center, Institut Curie Research Center, Paris, France; Medical Oncology Department, PSL Research University, Institut Curie Hospital, Paris, France.
Gruel N; INSERM U830, Équipe Labellisée LNCC, Diversity and Plasticity of Childhood Tumors Lab, PSL Research University, SIREDO Oncology Center, Institut Curie Research Center, Paris, France; Department of Translational Research, PSL Research University, Institut Curie Research Center, Paris, France.
Hénon C; ATIP-Avenir group, Inserm Unit U981, Gustave Roussy, Villejuif, France.
Postel-Vinay S; ATIP-Avenir group, Inserm Unit U981, Gustave Roussy, Villejuif, France; Drug Development Department, DITEP, Gustave Roussy, Villejuif, France.
Deloger M; Bioinformatics and Computational Systems Biology of Cancer, PSL Research University, Mines Paris Tech, INSERM U900, Paris, France.
Raynal V; Institut Curie Genomics of Excellence (ICGex) Platform, PSL Research University, Institut Curie Research Center, Paris, France.
Baulande S; Institut Curie Genomics of Excellence (ICGex) Platform, PSL Research University, Institut Curie Research Center, Paris, France.
Laud-Duval K; INSERM U830, Équipe Labellisée LNCC, Diversity and Plasticity of Childhood Tumors Lab, PSL Research University, SIREDO Oncology Center, Institut Curie Research Center, Paris, France.
Hill V; INSERM U830, Équipe Labellisée LNCC, Diversity and Plasticity of Childhood Tumors Lab, PSL Research University, SIREDO Oncology Center, Institut Curie Research Center, Paris, France.
Grossetête S; INSERM U830, Équipe Labellisée LNCC, Diversity and Plasticity of Childhood Tumors Lab, PSL Research University, SIREDO Oncology Center, Institut Curie Research Center, Paris, France.
Dingli F; Laboratoire de Spectrométrie de Masse Protéomique, PSL Research University, Institut Curie Research Center, Paris, France.
Loew D; Laboratoire de Spectrométrie de Masse Protéomique, PSL Research University, Institut Curie Research Center, Paris, France.
Torrejon J; Institut Curie, CNRS UMR3347, INSERM, PSL Research University, Orsay, France; CNRS UMR 3347, INSERM U1021, Université Paris Sud, Université Paris-Saclay, Orsay, France.
Ayrault O; Institut Curie, CNRS UMR3347, INSERM, PSL Research University, Orsay, France; CNRS UMR 3347, INSERM U1021, Université Paris Sud, Université Paris-Saclay, Orsay, France.
Orth MF; Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
Grünewald TGP; Division of Translational Pediatric Sarcoma Research, German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany; Hopp-Children's Cancer Center (KiTZ), Heidelberg, Germany; Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.
Surdez D; INSERM U830, Équipe Labellisée LNCC, Diversity and Plasticity of Childhood Tumors Lab, PSL Research University, SIREDO Oncology Center, Institut Curie Research Center, Paris, France.
Coulon A; Institut Curie, PSL Research University, Sorbonne Université, CNRS UMR 3664, Laboratoire Dynamique du Noyau, 75005 Paris, France; Institut Curie, PSL Research University, Sorbonne Université, CNRS UMR168, Laboratoire Physico Chimie Curie, 75005 Paris, France.
Waterfall JJ; INSERM U830, Integrative Functional Genomics of Cancer Lab, PSL Research University, Institut Curie Research Center, Paris, France; Department of Translational Research, PSL Research University, Institut Curie Research Center, Paris, France. Electronic address: .
Delattre O; INSERM U830, Équipe Labellisée LNCC, Diversity and Plasticity of Childhood Tumors Lab, PSL Research University, SIREDO Oncology Center, Institut Curie Research Center, Paris, France; Institut Curie, PSL Research University, Sorbonne Université, CNRS UMR 3664, Laboratoire Dynamique du Noyau, 75005 Paris, France. Electronic address: .
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Źródło:
Molecular cell [Mol Cell] 2022 Jul 07; Vol. 82 (13), pp. 2458-2471.e9. Date of Electronic Publication: 2022 May 11.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Carcinogenesis*/genetics
Gene Expression Regulation, Neoplastic*/genetics
Oncogene Proteins, Fusion*/genetics
Oncogene Proteins, Fusion*/metabolism
Proto-Oncogene Protein c-fli-1*/genetics
Proto-Oncogene Protein c-fli-1*/metabolism
Transcription Factors*/genetics
Cell Line, Tumor ; Gene Silencing ; Genome/genetics ; Genomics ; Humans ; Oncogenes/genetics ; Sarcoma, Ewing/genetics ; Sarcoma, Ewing/metabolism ; Sarcoma, Ewing/pathology ; Transcription, Genetic/genetics
Czasopismo naukowe
Tytuł:
A new role for ammonia in tumorigenesis?
Autorzy:
Lee HM; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Nayak A; Department of Biology, School of Arts and Science, Emory University, Atlanta, GA, USA.
Kim J; Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA. Electronic address: .
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Źródło:
Cell metabolism [Cell Metab] 2022 Jul 05; Vol. 34 (7), pp. 944-946.
Typ publikacji:
Journal Article
MeSH Terms:
Ammonia*/metabolism
Carcinogenesis*
Cell Transformation, Neoplastic ; Humans ; Lipogenesis ; Nitrogen/metabolism
Czasopismo naukowe
Tytuł:
Neural stemness unifies cell tumorigenicity and pluripotent differentiation potential.
Autorzy:
Zhang M; Shenzhen Research Institute of Nanjing University, Shenzhen, China; MOE Key Laboratory of Model Animals for Disease Study and State Key Laboratory of Pharmaceutical Biotechnology, Model Animal Research Center of Medical School, Nanjing University, Nanjing, China.
Liu Y; Shenzhen Research Institute of Nanjing University, Shenzhen, China; MOE Key Laboratory of Model Animals for Disease Study and State Key Laboratory of Pharmaceutical Biotechnology, Model Animal Research Center of Medical School, Nanjing University, Nanjing, China.
Shi L; MOE Key Laboratory of Model Animals for Disease Study and State Key Laboratory of Pharmaceutical Biotechnology, Model Animal Research Center of Medical School, Nanjing University, Nanjing, China.
Fang L; Jiangsu Key Laboratory of Molecular Medicine of Medical School, Nanjing University, Nanjing, China.
Xu L; MOE Key Laboratory of Model Animals for Disease Study and State Key Laboratory of Pharmaceutical Biotechnology, Model Animal Research Center of Medical School, Nanjing University, Nanjing, China.
Cao Y; Shenzhen Research Institute of Nanjing University, Shenzhen, China; MOE Key Laboratory of Model Animals for Disease Study and State Key Laboratory of Pharmaceutical Biotechnology, Model Animal Research Center of Medical School, Nanjing University, Nanjing, China. Electronic address: .
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Źródło:
The Journal of biological chemistry [J Biol Chem] 2022 Jul; Vol. 298 (7), pp. 102106. Date of Electronic Publication: 2022 Jun 04.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinogenesis*
Cell Differentiation*
Histone-Lysine N-Methyltransferase*/genetics
Histone-Lysine N-Methyltransferase*/metabolism
Neural Stem Cells*/cytology
Pluripotent Stem Cells*/cytology
Cell Cycle ; Embryonic Development ; Flavonoids
Czasopismo naukowe
Tytuł:
Improved Binding Affinity and Pharmacokinetics Enable Sustained Degradation of BCL6 In Vivo .
Autorzy:
Huckvale R; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, U.K.
Harnden AC; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, U.K.
Cheung KJ; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, U.K.
Pierrat OA; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, U.K.
Talbot R; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, U.K.
Box GM; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, U.K.
Henley AT; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, U.K.
de Haven Brandon AK; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, U.K.
Hallsworth AE; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, U.K.
Bright MD; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, U.K.
Akpinar HA; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, U.K.
Miller DSJ; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, U.K.
Tarantino D; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, U.K.
Gowan S; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, U.K.
Hayes A; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, U.K.
Gunnell EA; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, U.K.; Division of Structural Biology, The Institute of Cancer Research, London SM2 5NG, U.K.
Brennan A; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, U.K.
Davis OA; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, U.K.
Johnson LD; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, U.K.
de Klerk S; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, U.K.
McAndrew C; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, U.K.
Le Bihan YV; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, U.K.; Division of Structural Biology, The Institute of Cancer Research, London SM2 5NG, U.K.
Meniconi M; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, U.K.
Burke R; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, U.K.
Kirkin V; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, U.K.
van Montfort RLM; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, U.K.; Division of Structural Biology, The Institute of Cancer Research, London SM2 5NG, U.K.
Raynaud FI; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, U.K.
Rossanese OW; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, U.K.
Bellenie BR; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, U.K.
Hoelder S; Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London SM2 5NG, U.K.
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Źródło:
Journal of medicinal chemistry [J Med Chem] 2022 Jun 23; Vol. 65 (12), pp. 8191-8207. Date of Electronic Publication: 2022 Jun 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Carcinogenesis*
Gene Expression Regulation, Neoplastic*
Animals ; Humans ; Mice ; Proto-Oncogene Proteins c-bcl-6/metabolism
Czasopismo naukowe
Tytuł:
Deubiquitinating enzyme PSMD14 facilitates gastric carcinogenesis through stabilizing PTBP1.
Autorzy:
Li J; Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, PR China.
Li Y; Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, PR China.
Xu F; Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, PR China.
Sun B; Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, PR China.
Yang L; Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, PR China.
Wang H; Department of Gastroenterology Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, PR China. Electronic address: .
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Źródło:
Experimental cell research [Exp Cell Res] 2022 Jun 15; Vol. 415 (2), pp. 113148. Date of Electronic Publication: 2022 Apr 09.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinogenesis*/metabolism
Heterogeneous-Nuclear Ribonucleoproteins*/genetics
Heterogeneous-Nuclear Ribonucleoproteins*/metabolism
Polypyrimidine Tract-Binding Protein*/genetics
Polypyrimidine Tract-Binding Protein*/metabolism
Proteasome Endopeptidase Complex*/metabolism
Trans-Activators*/metabolism
Cell Line, Tumor ; Cell Proliferation ; Deubiquitinating Enzymes/genetics ; Deubiquitinating Enzymes/metabolism ; Gene Expression Regulation, Neoplastic/genetics ; Humans
Czasopismo naukowe
Tytuł:
Tumor-Associated Inflammation: The Tumor-Promoting Immunity in the Early Stages of Tumorigenesis.
Autorzy:
Bi Q; Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.; Institute of Urology, Capital Medical University, Beijing, China.
Wu JY; Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.; Institute of Urology, Capital Medical University, Beijing, China.
Qiu XM; Third Clinical Medical College, Capital Medical University, Beijing, China.
Zhang JD; Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.; Institute of Urology, Capital Medical University, Beijing, China.
Sun ZJ; Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.; Institute of Urology, Capital Medical University, Beijing, China.
Wang W; Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.; Institute of Urology, Capital Medical University, Beijing, China.
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Źródło:
Journal of immunology research [J Immunol Res] 2022 Jun 13; Vol. 2022, pp. 3128933. Date of Electronic Publication: 2022 Jun 13 (Print Publication: 2022).
Typ publikacji:
Journal Article; Review
MeSH Terms:
Carcinogenesis*/metabolism
Neoplasms*
Cell Transformation, Neoplastic ; Humans ; Inflammasomes ; Inflammation/pathology
Czasopismo naukowe
Tytuł:
A computational model of organism development and carcinogenesis resulting from cells' bioelectric properties and communication.
Autorzy:
Carvalho J; CFisUC, Department of Physics, University of Coimbra, Coimbra, Portugal. .
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Źródło:
Scientific reports [Sci Rep] 2022 Jun 02; Vol. 12 (1), pp. 9206. Date of Electronic Publication: 2022 Jun 02.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Carcinogenesis*
Cell Communication*
Electrophysiological Phenomena*
Carcinogens ; Cell Proliferation ; Computer Simulation ; Humans
Czasopismo naukowe
Tytuł:
Olfactory sensory experience regulates gliomagenesis via neuronal IGF1.
Autorzy:
Chen P; Department of Neurobiology and Department of Neurosurgery of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P.R. China.; Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, P.R. China.; NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Science and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, P.R. China.; Department of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou, P.R. China.
Wang W; Department of Neurobiology and Department of Neurosurgery of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P.R. China.; Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, P.R. China.; NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Science and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, P.R. China.
Liu R; Department of Neurobiology and Department of Neurosurgery of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P.R. China.; Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, P.R. China.; NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Science and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, P.R. China.
Lyu J; Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, P.R. China.
Zhang L; Department of Neurobiology and Department of Neurosurgery of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P.R. China.; Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, P.R. China.; NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Science and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, P.R. China.; Department of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou, P.R. China.
Li B; Department of Pathology of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P.R. China.
Qiu B; Department of Neurobiology and Department of Neurosurgery of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P.R. China.; Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, P.R. China.; NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Science and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, P.R. China.; Department of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou, P.R. China.
Tian A; Department of Neurobiology and Department of Neurosurgery of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P.R. China.; Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, P.R. China.; NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Science and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, P.R. China.
Jiang W; Department of Neurobiology and Department of Neurosurgery of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P.R. China.; Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, P.R. China.; NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Science and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, P.R. China.; Department of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou, P.R. China.
Ying H; Department of Neurobiology and Department of Neurosurgery of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P.R. China.; Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, P.R. China.; NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Science and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, P.R. China.
Jing R; Department of Neurobiology and Department of Neurosurgery of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P.R. China.; Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, P.R. China.; NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Science and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, P.R. China.; Department of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou, P.R. China.
Wang Q; Laboratory Animal Center of Zhejiang University, Hangzhou, P.R. China.
Zhu K; Department of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou, P.R. China.
Bai R; Department of Physical Medicine and Rehabilitation of The Affiliated Sir Run Shumen Shaw Hospital and Interdisciplinary Institute of Neuroscience and Technology, Zhejiang University School of Medicine, Hangzhou, P.R. China.
Zeng L; Department of Pharmacology, School of Medicine, Zhejiang University City College, Hangzhou, P.R. China.
Duan S; Department of Neurobiology and Department of Neurosurgery of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P.R. China.; Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, P.R. China.; NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Science and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, P.R. China.; Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, P.R. China.; The Institute of Brain and Cognitive Sciences, Zhejiang University City College, Hangzhou, P.R. China.; Chuanqi Research and Development Center of Zhejiang University, Hangzhou, P.R. China.
Liu C; Department of Neurobiology and Department of Neurosurgery of Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P.R. China. .; Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, P.R. China. .; NHC and CAMS Key Laboratory of Medical Neurobiology, MOE Frontier Science Center for Brain Science and Brain-Machine Integration, School of Brain Science and Brain Medicine, Zhejiang University, Hangzhou, P.R. China. .; The Institute of Brain and Cognitive Sciences, Zhejiang University City College, Hangzhou, P.R. China. .; Chuanqi Research and Development Center of Zhejiang University, Hangzhou, P.R. China. .
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Źródło:
Nature [Nature] 2022 Jun; Vol. 606 (7914), pp. 550-556. Date of Electronic Publication: 2022 May 11.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinogenesis*
Glioma*/metabolism
Glioma*/pathology
Insulin-Like Growth Factor I*
Olfactory Receptor Neurons*/physiology
Smell*/physiology
Animals ; Mice ; Neural Pathways ; Olfactory Bulb/pathology
Czasopismo naukowe
Tytuł:
The renal lineage factor PAX8 controls oncogenic signalling in kidney cancer.
Autorzy:
Patel SA; MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge Biomedical Campus, Cambridge, UK.; Wellcome Sanger Institute, Cambridge, UK.
Hirosue S; MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge Biomedical Campus, Cambridge, UK.
Rodrigues P; MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge Biomedical Campus, Cambridge, UK.
Vojtasova E; MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge Biomedical Campus, Cambridge, UK.
Richardson EK; MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge Biomedical Campus, Cambridge, UK.; Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore.
Ge J; MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge Biomedical Campus, Cambridge, UK.
Syafruddin SE; MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge Biomedical Campus, Cambridge, UK.; UKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia, Jalan Yaacob Latiff, Bandar Tun Razak, Malaysia.
Speed A; MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge Biomedical Campus, Cambridge, UK.
Papachristou EK; Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, UK.
Baker D; Quadram Institute Bioscience, Norwich Research Park, Norwich, UK.
Clarke D; Cambridge Genomics Laboratory, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Purvis S; Cambridge Genomics Laboratory, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Wesolowski L; MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge Biomedical Campus, Cambridge, UK.
Dyas A; MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge Biomedical Campus, Cambridge, UK.
Castillon L; MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge Biomedical Campus, Cambridge, UK.; Translational Cancer Medicine Program, Faculty of Medicine, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.
Caraffini V; MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge Biomedical Campus, Cambridge, UK.
Bihary D; MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge Biomedical Campus, Cambridge, UK.
Yong C; Department of Surgery, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Harrison DJ; School of Medicine, University of St Andrews, St Andrews, UK.
Stewart GD; Department of Surgery, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
Machiela MJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Purdue MP; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Chanock SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Warren AY; Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Samarajiwa SA; MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge Biomedical Campus, Cambridge, UK.
Carroll JS; Cancer Research UK Cambridge Institute, University of Cambridge, Robinson Way, Cambridge, UK.
Vanharanta S; MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge Biomedical Campus, Cambridge, UK. .; Translational Cancer Medicine Program, Faculty of Medicine, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland. .; Department of Physiology, Faculty of Medicine, University of Helsinki, Helsinki, Finland. .
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Źródło:
Nature [Nature] 2022 Jun; Vol. 606 (7916), pp. 999-1006. Date of Electronic Publication: 2022 Jun 08.
Typ publikacji:
Journal Article
MeSH Terms:
Carcinogenesis*/genetics
Kidney Neoplasms*/metabolism
Kidney Neoplasms*/pathology
PAX8 Transcription Factor*/genetics
PAX8 Transcription Factor*/metabolism
Signal Transduction*
Alleles ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Carcinoma, Renal Cell/metabolism ; Carcinoma, Renal Cell/pathology ; Cyclin D1/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Kidney/metabolism ; Kidney/pathology ; Mutation ; Proto-Oncogene Proteins c-myc/genetics ; Von Hippel-Lindau Tumor Suppressor Protein/genetics
Czasopismo naukowe
Tytuł:
Bile Acid-Microbiome Interaction Promotes Gastric Carcinogenesis.
Autorzy:
Wang S; Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
Kuang J; Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
Zhang H; Department of Metabolic and Bariatric Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
Chen W; Cancer Institute, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200233, China.
Zheng X; Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
Wang J; Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
Huang F; Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
Ge K; Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
Li M; Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
Zhao M; Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
Rajani C; Cancer Biology Program, University of Hawaii Cancer Center, Honolulu, HI, 96813, USA.
Zhu J; Department of Gastroenterology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
Zhao A; Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
Jia W; Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.; Cancer Biology Program, University of Hawaii Cancer Center, Honolulu, HI, 96813, USA.; School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, 999077, China.
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Źródło:
Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2022 May; Vol. 9 (16), pp. e2200263. Date of Electronic Publication: 2022 Mar 14.
Typ publikacji:
Journal Article
MeSH Terms:
Bile Reflux*/complications
Bile Reflux*/pathology
Carcinogenesis*/metabolism
Gastritis*/complications
Gastritis*/pathology
Gastrointestinal Microbiome*
Stomach Neoplasms*/etiology
Stomach Neoplasms*/metabolism
Taurodeoxycholic Acid*/metabolism
Animals ; Humans ; Interleukin-6/metabolism ; Lipopolysaccharides ; Mice
Czasopismo naukowe
Tytuł:
The transcriptional regulation of normal and malignant blood cell development.
Autorzy:
Edginton-White B; Institute of Cancer and Genomic Sciences, College of Medicine and Dentistry, University of Birmingham, UK.
Bonifer C; Institute of Cancer and Genomic Sciences, College of Medicine and Dentistry, University of Birmingham, UK.
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Źródło:
The FEBS journal [FEBS J] 2022 Mar; Vol. 289 (5), pp. 1240-1255. Date of Electronic Publication: 2021 Feb 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:
Transcription, Genetic*
Blood Cells/*metabolism
Carcinogenesis/*genetics
Hematologic Neoplasms/*genetics
Hematopoietic Stem Cells/*metabolism
Transcription Factors/*genetics
Blood Cells/classification ; Blood Cells/cytology ; Carcinogenesis/metabolism ; Carcinogenesis/pathology ; Cell Communication ; Cell Differentiation ; Cell Lineage/genetics ; Chromatin/chemistry ; Chromatin/metabolism ; Gene Expression Regulation, Neoplastic ; Gene Regulatory Networks ; Hematologic Neoplasms/metabolism ; Hematologic Neoplasms/pathology ; Hematopoiesis/genetics ; Hematopoietic Stem Cells/cytology ; Humans ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Signal Transduction ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł:
Impacts of Cancer-associated Mutations on the Structure-Activity Relationship of BAP1.
Autorzy:
Puri S; Institute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan. Electronic address: https://twitter.com/Saritapuri1504.
Chen SN; Institute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan. Electronic address: .
Chiu YH; Institute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan; Institute of Biochemical Sciences, National Taiwan University, Taipei 10617, Taiwan.
Draczkowski P; Institute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan.
Ko KT; Institute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan.
Yang TJ; Institute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan; Institute of Biochemical Sciences, National Taiwan University, Taipei 10617, Taiwan. Electronic address: https://twitter.com/TzuJingYang.
Wang YS; Institute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan; Institute of Biochemical Sciences, National Taiwan University, Taipei 10617, Taiwan.
Uchiyama S; Department of Biotechnology, Osaka University, Osaka 565-0871, Japan; U-Medico Inc. 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan; Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, Okazaki, Aichi 444-8787, Japan.
Hsu SD; Institute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan; Institute of Biochemical Sciences, National Taiwan University, Taipei 10617, Taiwan. Electronic address: .
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Źródło:
Journal of molecular biology [J Mol Biol] 2022 May 15; Vol. 434 (9), pp. 167553. Date of Electronic Publication: 2022 Mar 19.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Carcinogenesis*/genetics
Tumor Suppressor Proteins*/chemistry
Tumor Suppressor Proteins*/genetics
Tumor Suppressor Proteins*/metabolism
Ubiquitin Thiolesterase*/chemistry
Ubiquitin Thiolesterase*/genetics
Ubiquitin Thiolesterase*/metabolism
Humans ; Mutation ; Protein Domains ; Structure-Activity Relationship
Czasopismo naukowe

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