Temat: "Carcinogenicity Tests" - OpacWWW

Skocz do pozycji: 61.

Tytuł:: Thoughts on carcinogenesis testing: the FDA today.
Autorzy:: Schwetz BA; U.S. Food and Drug Administration, Rockville, Maryland 20857.; Pokaż więcej
Źródło:: Drug metabolism reviews [Drug Metab Rev] 2000 May; Vol. 32 (2), pp. 211-4.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Carcinogenicity Tests*/methods
Carcinogenicity Tests*/trends
Neoplasms*/epidemiology
Neoplasms*/prevention & control
United States Food and Drug Administration*
Animals ; Humans ; Risk Management ; United States

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Skocz do pozycji: 62.

Tytuł:: Chemically induced renal tubule tumors in the laboratory rat and mouse: review of the NCI/NTP database and categorization of renal carcinogens based on mechanistic information.
Autorzy:: Lock EA; Syngenta Central Toxicology Laboratory, Macclesfield, Cheshire, United Kingdom. />Hard GC; Pokaż więcej
Źródło:: Critical reviews in toxicology [Crit Rev Toxicol] 2004 May-Jun; Vol. 34 (3), pp. 211-99.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:: Carcinogenicity Tests*
Adenoma/*chemically induced
Carcinogens/*toxicity
Kidney Neoplasms/*chemically induced
Kidney Tubules/*drug effects
Adenoma/pathology ; Animals ; Carcinogens/classification ; Carcinogens/metabolism ; Databases, Factual ; Female ; Kidney Neoplasms/pathology ; Kidney Tubules/pathology ; Male ; Mice ; Mice, Inbred Strains ; National Health Programs ; National Institutes of Health (U.S.) ; Rats ; Rats, Inbred F344 ; United States

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Skocz do pozycji: 63.

Tytuł:: Assessing assays.
Autorzy:: Schmidt CW; Pokaż więcej
Źródło:: Environmental health perspectives [Environ Health Perspect] 2002 May; Vol. 110 (5), pp. A248-51.
Typ publikacji:: Journal Article
MeSH Terms:: Disease Models, Animal*
Carcinogenicity Tests/*standards
Neoplasms/*etiology
Animals ; Animals, Genetically Modified ; Carcinogenicity Tests/statistics & numerical data ; Environmental Health ; Humans ; Reproducibility of Results ; Risk Assessment/methods

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Szczegóły

Skocz do pozycji: 64.

Tytuł:: Data quality in predictive toxicology: reproducibility of rodent carcinogenicity experiments.
Autorzy:: Gottmann E; Institute for Cancer Research, Institute for Environmental Hygiene, University Vienna, Vienna, Austria. />Kramer S
Pfahringer B
Helma C; Pokaż więcej
Źródło:: Environmental health perspectives [Environ Health Perspect] 2001 May; Vol. 109 (5), pp. 509-14.
Typ publikacji:: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Carcinogenicity Tests/*statistics & numerical data
Carcinogens/*toxicity
Neoplasms/*chemically induced
Animals ; Carcinogenicity Tests/standards ; Carcinogens/chemistry ; Databases, Factual ; Female ; Male ; Mice ; Predictive Value of Tests ; Rats ; Reproducibility of Results ; Risk Assessment ; Species Specificity ; Structure-Activity Relationship

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Skocz do pozycji: 65.

Tytuł:: Dose-response analyses of experimental cancer data.
Autorzy:: Melnick RL; Laboratory of Computational Biology and Risk Analysis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA. />Kohn MC; Pokaż więcej
Źródło:: Drug metabolism reviews [Drug Metab Rev] 2000 May; Vol. 32 (2), pp. 193-209.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Carcinogenicity Tests*
Dose-Response Relationship, Drug*
Animals ; Carcinogens/pharmacokinetics ; Carcinogens/toxicity ; Data Interpretation, Statistical ; Humans ; Mice ; Neoplasms, Experimental/chemically induced ; Neoplasms, Experimental/metabolism ; Rats ; Risk Assessment/methods ; Risk Factors

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Skocz do pozycji: 66.

Tytuł:: Laboratory animal tests and human cancer.
Autorzy:: Rall DP; Pokaż więcej
Źródło:: Drug metabolism reviews [Drug Metab Rev] 2000 May; Vol. 32 (2), pp. 119-28.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Carcinogenicity Tests*
Neoplasms, Experimental*
Carcinogens/*toxicity
Animals ; Animals, Laboratory ; Humans ; Rodentia

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Skocz do pozycji: 67.

Tytuł:: Metabolic activation capacity of neonatal mice in relation to the neonatal mouse tumorigenicity bioassay.
Autorzy:: Fu PP; National Center for Toxicological Research, Jefferson, Arkansas 72079, USA.
Von Tungeln LS
Hammons GJ
McMahon G
Wogan G
Flammang TJ
Kadlubar FF; Pokaż więcej
Źródło:: Drug metabolism reviews [Drug Metab Rev] 2000 May; Vol. 32 (2), pp. 241-66.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Biotransformation*
Carcinogenicity Tests*/methods
Carcinogens/*toxicity
Animals ; Animals, Newborn ; Carcinogens/metabolism ; Cytochrome P-450 Enzyme System/metabolism ; DNA Adducts ; Humans ; Mice ; Rats ; ras Proteins/biosynthesis

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Skocz do pozycji: 68.

Tytuł:: New issues in cancer risk assessment.
Autorzy:: Gaylor DW; National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079.; Pokaż więcej
Źródło:: Drug metabolism reviews [Drug Metab Rev] 2000 May; Vol. 32 (2), pp. 187-92.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Carcinogenicity Tests*
Neoplasms*/epidemiology
Risk Assessment/*methods
Animals ; Humans ; Mice ; Risk Assessment/trends ; Species Specificity

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Skocz do pozycji: 69.

Tytuł:: Can rodent cancer tests predict for human cancers? Proceedings of a toxicology symposium. Little Rock, Arkansas, USA. November 12-13, 1998.
Źródło:: Drug metabolism reviews [Drug Metab Rev] 2000 May; Vol. 32 (2), pp. 119-266.
Typ publikacji:: Congress; Overall; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
MeSH Terms:: Carcinogenicity Tests*
Neoplasms, Experimental*
Carcinogens/*toxicity
Animals ; Animals, Laboratory ; Humans ; Rodentia

Raport

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Skocz do pozycji: 70.

Tytuł:: Risk assessment for possible carcinogens: a critical look.
Autorzy:: Farber E; Department of Pathology and Cell Biology, University of South Carolina Medical School, Columbia 29209, USA.; Pokaż więcej
Źródło:: Drug metabolism reviews [Drug Metab Rev] 2000 May; Vol. 32 (2), pp. 143-51.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Carcinogenicity Tests*
Carcinogens/*toxicity
Neoplasms/*chemically induced
Cell Division/drug effects ; Cell Transformation, Neoplastic ; DNA/drug effects ; DNA/metabolism ; Humans ; Intercellular Junctions/drug effects ; Risk Assessment ; Risk Factors

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Skocz do pozycji: 71.

Tytuł:: Doses in rodent cancer studies: sorting fact from fiction.
Autorzy:: Bucher JR; National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA.; Pokaż więcej
Źródło:: Drug metabolism reviews [Drug Metab Rev] 2000 May; Vol. 32 (2), pp. 153-63.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Carcinogenicity Tests/*standards
Carcinogens/*toxicity
Neoplasms, Experimental/*chemically induced
Animals ; Carcinogenicity Tests/methods ; Carcinogens/pharmacokinetics ; Humans ; Neoplasms, Experimental/metabolism ; Rats ; Rodentia ; Species Specificity

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Skocz do pozycji: 72.

Tytuł:: Expression and in vitro assessment of tumorigenicity for NOD1 and NOD2 receptors in breast cancer cell lines.
Autorzy:: Velloso FJ; Cell and Molecular Therapy Center (NUCEL-NETCEM), Internal Medicine Department, School of Medicine, University of São Paulo (USP), São Paulo, SP, 05360-130, Brazil.
Sogayar MC; Cell and Molecular Therapy Center (NUCEL-NETCEM), Internal Medicine Department, School of Medicine, University of São Paulo (USP), São Paulo, SP, 05360-130, Brazil.
Correa RG; Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Rd., La Jolla, CA, 92037, USA. .; Pokaż więcej
Źródło:: BMC research notes [BMC Res Notes] 2018 Apr 03; Vol. 11 (1), pp. 222. Date of Electronic Publication: 2018 Apr 03.
Typ publikacji:: Journal Article
MeSH Terms:: Gene Expression Profiling*
Nod1 Signaling Adaptor Protein/*metabolism
Nod2 Signaling Adaptor Protein/*metabolism
Breast Neoplasms ; Carcinogenicity Tests ; Cell Line, Tumor ; Female ; Humans

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Skocz do pozycji: 73.

Tytuł:: Verification of a false positive in a two-year rat carcinogenicity study using dual control groups.
Autorzy:: Ogawa S; Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.
Kuroda H; R&D PLANNING, Zeria Pharmaceutical Co., Ltd.
Kinomoto T; Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.
Kawabata Y; Central Research Laboratories, Zeria Pharmaceutical Co., Ltd.
Kawabe M; DIMS Institute of Medical Science, Inc.
Suguro M; DIMS Institute of Medical Science, Inc.
Oishi Y; Department Molecular Pathology, Osaka City University.; Pokaż więcej
Źródło:: The Journal of toxicological sciences [J Toxicol Sci] 2018; Vol. 43 (9), pp. 557-563.
Typ publikacji:: Journal Article
MeSH Terms:: Control Groups*
Adenocarcinoma/*chemically induced
Benzamides/*toxicity
Carcinogenicity Tests/*methods
Endometrial Neoplasms/*chemically induced
Thiazoles/*toxicity
Administration, Oral ; Animals ; Benzamides/administration & dosage ; False Positive Reactions ; Female ; Rats, Inbred F344 ; Thiazoles/administration & dosage ; Time Factors

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Skocz do pozycji: 74.

Tytuł:: The use of transgenic animals in cancer testing.
Autorzy:: French JE; National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA.
Spalding JW
Dunnick JK
Tice RR
Furedi-Machacek M
Tennant RW; Pokaż więcej
Źródło:: Inhalation toxicology [Inhal Toxicol] 1999 Jun-Jul; Vol. 11 (6-7), pp. 541-4.
Typ publikacji:: Journal Article; Review
MeSH Terms:: Carcinogenicity Tests*
Animals, Genetically Modified/*physiology
Animals ; Genes, ras/genetics ; Mice ; Mice, Transgenic

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Skocz do pozycji: 75.

Tytuł:: Regulation of Chromatin Assembly and Cell Transformation by Formaldehyde Exposure in Human Cells.
Autorzy:: Chen D; Department of Environmental Medicine and Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, New York, USA.
Fang L; Department of Environmental Medicine and Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, New York, USA.
Mei S; Department of Bioinformatics, School of Life Sciences, Tongji University, Shanghai, China.
Li H; Department of Environmental Medicine and Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, New York, USA.
Xu X; Department of Environmental Medicine and Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, New York, USA.
Des Marais TL; Department of Environmental Medicine and Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, New York, USA.
Lu K; Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina, USA.
Liu XS; Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute and Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Jin C; Department of Environmental Medicine and Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, New York, USA.; Pokaż więcej
Źródło:: Environmental health perspectives [Environ Health Perspect] 2017 Sep 21; Vol. 125 (9), pp. 097019. Date of Electronic Publication: 2017 Sep 21.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
MeSH Terms:: Cell Transformation, Neoplastic/*chemically induced
Chromatin Assembly and Disassembly/*physiology
Formaldehyde/*toxicity
Hazardous Substances/*toxicity
Carcinogenicity Tests ; Cell Line, Tumor ; Humans

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Skocz do pozycji: 76.

Tytuł:: Is Nickel Chloride really a Non-Genotoxic Carcinogen?
Autorzy:: Stannard L; In Vitro Toxicology Group, Institute of Life Science, Swansea University Medical School, Swansea University, Swansea, Wales, UK.
Doak SH; In Vitro Toxicology Group, Institute of Life Science, Swansea University Medical School, Swansea University, Swansea, Wales, UK.
Doherty A; Genetic Toxicology, Drug Safety and Metabolism, AstraZeneca R&D, Cambridge, UK.
Jenkins GJ; In Vitro Toxicology Group, Institute of Life Science, Swansea University Medical School, Swansea University, Swansea, Wales, UK.; Pokaż więcej
Źródło:: Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2017 Sep; Vol. 121 Suppl 3, pp. 10-15. Date of Electronic Publication: 2016 Dec 22.
Typ publikacji:: Journal Article; Review
MeSH Terms:: DNA Damage*
Carcinogens, Environmental/*toxicity
Environmental Exposure/*adverse effects
Mutagens/*toxicity
Neoplasms/*etiology
Nickel/*toxicity
Animals ; Carcinogenicity Tests ; DNA/genetics ; Humans ; Reactive Oxygen Species/metabolism ; Time Factors

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Skocz do pozycji: 77.

Tytuł:: The role of Lutheran/basal cell adhesion molecule in human bladder carcinogenesis.
Autorzy:: Chang HY; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China.; Department of Urology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China.
Chang HM; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China.
Wu TJ; Department of Pathology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China.
Chaing CY; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China.
Tzai TS; Department of Urology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China.
Cheng HL; Department of Urology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China.
Raghavaraju G; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China.
Chow NH; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China. .; Department of Pathology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China. .
Liu HS; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China. .; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China. .; Center of Infectious Disease and Signaling Research, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China. .; Pokaż więcej
Źródło:: Journal of biomedical science [J Biomed Sci] 2017 Aug 26; Vol. 24 (1), pp. 61. Date of Electronic Publication: 2017 Aug 26.
Typ publikacji:: Journal Article
MeSH Terms:: Signal Transduction*
Carcinogenesis/*genetics
Cell Adhesion Molecules/*genetics
Lutheran Blood-Group System/*genetics
Urinary Bladder Neoplasms/*genetics
Animals ; Carcinogenicity Tests ; Cell Adhesion Molecules/metabolism ; Cell Line, Tumor ; Fibroblasts ; Humans ; Laminin/genetics ; Ligands ; Lutheran Blood-Group System/metabolism ; Mice ; NIH 3T3 Cells ; Transcriptome

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Skocz do pozycji: 78.

Tytuł:: Potential carcinogenicity predicted by computational toxicity evaluation of thiophosphate pesticides using QSTR/QSCarciAR model.
Autorzy:: Petrescu AM; a Department of Biology-Chemistry , Faculty of Chemistry, Biology, Geography, West University of Timisoara , Timisoara , Romania and.
Ilia G; a Department of Biology-Chemistry , Faculty of Chemistry, Biology, Geography, West University of Timisoara , Timisoara , Romania and.; b Institute of Chemistry Timisoara of Romanian Academy , Timisoara , Romania.; Pokaż więcej
Źródło:: Drug and chemical toxicology [Drug Chem Toxicol] 2017 Jul; Vol. 40 (3), pp. 263-272. Date of Electronic Publication: 2016 Jul 27.
Typ publikacji:: Journal Article
MeSH Terms:: Models, Biological*
Quantitative Structure-Activity Relationship*
Carcinogens/*toxicity
Computational Biology/*methods
Pesticides/*toxicity
Phosphates/*toxicity
Animals ; Carcinogenicity Tests ; Carcinogens/chemistry ; Lethal Dose 50 ; Mice ; Molecular Structure ; Molecular Weight ; Pesticides/chemistry ; Phosphates/chemistry ; Predictive Value of Tests ; Rats ; Regression Analysis ; Software

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Skocz do pozycji: 79.

Tytuł:: Continuous long-term cytotoxicity monitoring in 3D spheroids of beetle luciferase-expressing hepatocytes by nondestructive bioluminescence measurement.
Autorzy:: Yasunaga M; Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Takamatsu, Kagawa, 761-0395, Japan.
Fujita Y; Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Takamatsu, Kagawa, 761-0395, Japan.
Saito R; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, 980-8573, Japan.
Oshimura M; Chromosome Engineering Research Center, Tottori University, Yonago, Tottori, 683-8503, Japan.
Nakajima Y; Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Takamatsu, Kagawa, 761-0395, Japan. .; Chromosome Engineering Research Center, Tottori University, Yonago, Tottori, 683-8503, Japan. .; Pokaż więcej
Źródło:: BMC biotechnology [BMC Biotechnol] 2017 Jun 20; Vol. 17 (1), pp. 54. Date of Electronic Publication: 2017 Jun 20.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Carcinogenicity Tests/*methods
Coleoptera/*enzymology
Hepatocytes/*drug effects
Luciferases/*metabolism
Luminescent Measurements/*methods
Spheroids, Cellular/*drug effects
Toxins, Biological/*toxicity
Animals ; Biological Assay/methods ; Cells, Cultured ; Genes, Reporter/genetics ; Hepatocytes/enzymology ; Hepatocytes/pathology ; Longitudinal Studies ; Luciferases/genetics ; Mice ; Spheroids, Cellular/enzymology ; Spheroids, Cellular/pathology

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Skocz do pozycji: 80.

Tytuł:: Stem cell proliferation patterns as an alternative for in vivo prediction and discrimination of carcinogenic compounds.
Autorzy:: Stevens AS; Zoology: Biodiversity and Toxicology, Centre for Environmental Sciences, Hasselt University, Agoralaan, building D, BE 3590, Diepenbeek, Belgium.
Willems M; Laboratory of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, BE 9000, Ghent, Belgium.; Laboratory of Environmental Toxicology and Aquatic Ecology, Ghent University, Jozef Plateaustraat 22, BE 9000 Ghent, Belgium.
Plusquin M; MRC/PHE Centre for Environment and Health, School of Public Health, Imperial College London, St Mary's Campus, Norfolk Place W2 1PG, London, United Kingdom.; Environmental biology, Centre for Environmental Sciences, Hasselt University, Agoralaan, building D, BE 3590, Diepenbeek, Belgium.
Ploem JP; Zoology: Biodiversity and Toxicology, Centre for Environmental Sciences, Hasselt University, Agoralaan, building D, BE 3590, Diepenbeek, Belgium.
Winckelmans E; Environmental biology, Centre for Environmental Sciences, Hasselt University, Agoralaan, building D, BE 3590, Diepenbeek, Belgium.
Artois T; Zoology: Biodiversity and Toxicology, Centre for Environmental Sciences, Hasselt University, Agoralaan, building D, BE 3590, Diepenbeek, Belgium.
Smeets K; Zoology: Biodiversity and Toxicology, Centre for Environmental Sciences, Hasselt University, Agoralaan, building D, BE 3590, Diepenbeek, Belgium.; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2017 May 03; Vol. 7, pp. 45616. Date of Electronic Publication: 2017 May 03.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Platyhelminths*
Carcinogenicity Tests/*methods
Carcinogens/*analysis
Cell Proliferation/*drug effects
Stem Cells/*drug effects
Stem Cells/*physiology
Animals ; Cells, Cultured ; Mutagens/analysis

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