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Wyszukujesz frazę ""Carcinoma, Non-Small-Cell Lung genetics"" wg kryterium: Temat


Tytuł :
A KRAS-responsive long non-coding RNA controls microRNA processing
Autorzy :
Lei Shi
Peter Magee
Matteo Fassan
Sudhakar Sahoo
Hui Sun Leong
Dave Lee
Robert Sellers
Laura Brullé-Soumaré
Stefano Cairo
Tiziana Monteverde
Stefano Volinia
Duncan D. Smith
Gianpiero Di Leva
Francesca Galuppini
Athanasios R. Paliouras
Kang Zeng
Raymond O’Keefe
Michela Garofalo
Pokaż więcej
Temat :
Article
Long non-coding RNAs
Non-small-cell lung cancer
General Physics and Astronomy
General Biochemistry, Genetics and Molecular Biology
General Chemistry
R735
lcsh:Science
lcsh:Q
A549 Cells
Animals
Carcinoma, Non-Small-Cell Lung/genetics
Cell Line, Tumor
Female
Gene Expression Profiling/methods
Gene Expression Regulation, Neoplastic
Gene Ontology
Humans
Kaplan-Meier Estimate
Lung Neoplasms/genetics
Mice, Inbred NOD
Mice, Knockout
Mice, SCID
MicroRNAs/genetics
Proto-Oncogene Proteins p21(ras)/genetics
RNA, Long Noncoding/genetics
Xenograft Model Antitumor Assays/methods
respiratory tract diseases
digestive system diseases
neoplasms
Źródło :
Nature Communications
Crossref
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Shi, L, Magee, P, Fassan, M, Sahoo, S, Leong, H S, Lee, D, Sellers, R, Brullé-Soumaré, L, Cairo, S, Monteverde, T, Volinia, S, Smith, D D, Di Leva, G, Galuppini, F, Paliouras, A R, Zeng, K, O'Keefe, R & Garofalo, M 2021, ' A KRAS-responsive long non-coding RNA controls microRNA processing ', Nature Communications, vol. 12, no. 1, 2038 . https://doi.org/10.1038/s41467-021-22337-3
Opis pliku :
application/pdf
Dostępność :
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d51af05ca11b5e8f61a88aae8dfc0a6
http://europepmc.org/articles/PMC8016872
Tytuł :
NF-κB-Induced Upregulation of miR-548as-3p Increases Invasion of NSCLC by Targeting PTEN
Autorzy :
Arsenal Sezgin Alikanoglu
Sakir Akgun
Mustafa Yildiz
Osman N. Ozes
Ozge Can
Hakan Akca
Hakan Kucuksayan
Pokaż więcej
Temat :
Cancer Research
Pharmacology
Molecular Medicine
Cancer research
Oncogene
Transcriptional regulation
NFKB1
Metastasis
medicine.disease
medicine
Transcription factor
PI3K/AKT/mTOR pathway
microRNA
PTEN
biology.protein
biology
Carcinoma
Invasion
miR-548as-3p
Neoplasm metastasis
NF-kappa B
Non-small-cell lung
gelatinase B
immunoglobulin enhancer binding protein
microRNA 548as 3p
phosphatidylinositol 3 kinase
phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase
protein kinase B
transcription factor Slug
transcription factor ZEB1
tumor necrosis factor
unclassified drug
messenger RNA
MIRN548 microRNA, human
PTEN protein, human
Article
binding site
bioinformatics
cancer tissue
cell invasion
chromatin immunoprecipitation
controlled study
DNA binding
gel mobility shift assay
gene expression
human
human cell
human tissue
MTT assay
NCI-H1299 cell line
non small cell lung cancer
promoter region
protein targeting
real time polymerase chain reaction
signal transduction
transcription initiation site
transcription regulation
upregulation
Western blotting
biosynthesis
cell survival
chemical structure
dose response
genetics
HEK293 cell line
lung tumor
metabolism
pathology
structure activity relation
Carcinoma, Non-Small-Cell Lung
Dose-Response Relationship, Drug
HEK293 Cells
Humans
Lung Neoplasms
MicroRNAs
Molecular Structure
PTEN Phosphohydrolase
RNA, Messenger
Structure-Activity Relationship
Up-Regulation
Carcinoma, Non-Small-Cell Lung/*genetics/metabolism/*pathology
Cell Survival
Lung Neoplasms/*genetics/metabolism/*pathology
MicroRNAs/biosynthesis/*genetics
NF-kappa B/*metabolism
PTEN Phosphohydrolase/*genetics/metabolism
RNA, Messenger/genetics/metabolism
Źródło :
Crossref
Dostępność :
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ee1f8d04a6a79a5db3136a8e80be8d8
http://eurekaselect.com/article/download/169698
Tytuł :
miRNA-mediated TUSC3 deficiency enhances UPR and ERAD to promote metastatic potential of NSCLC
Autorzy :
Jeon, Young-Jun
Kim, Taewan
Park, Dongju
Nuovo, Gerard J.
Rhee, Siyeon
Joshi, Pooja
Lee, Bum-Kyu
Jeong, Johan
Suh, Sung-suk
Grotzke, Jeff E.
Kim, Sung-Hak
Song, Jieun
Sim, Hosung
Kim, Yonghwan
Peng, Yong
Jeong, Youngtae
Garofalo, Michela
Zanesi, Nicola
Kim, Jonghwan
Liang, Guang
Nakano, Ichiro
Cresswell, Peter
Nana-Sinkam, Patrick
Cui, Ri
Croce, Carlo M.
Pokaż więcej
Temat :
Science
Activating Transcription Factor 6/genetics
Animals
Carcinoma, Non-Small-Cell Lung/genetics
Cell Line, Tumor
Cell Proliferation/genetics
Endoplasmic Reticulum-Associated Degradation/genetics
Endoribonucleases/genetics
Gene Expression Regulation, Neoplastic/genetics
Humans
In Situ Hybridization
Lung Neoplasms/genetics
Membrane Proteins/genetics
Mice
MicroRNAs/metabolism
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction/genetics
Tumor Suppressor Protein p53/genetics
Tumor Suppressor Proteins/genetics
Ubiquitin-Protein Ligases/genetics
Unfolded Protein Response/genetics
Xenograft Model Antitumor Assays
Article
General Physics and Astronomy
General Biochemistry, Genetics and Molecular Biology
General Chemistry
Cancer
medicine.disease
medicine
Suppressor
law.invention
law
Carcinoma
Unfolded protein response
Cancer research
microRNA
Cell
medicine.anatomical_structure
business.industry
business
Regulation of gene expression
Lung cancer
lcsh:Science
lcsh:Q
Źródło :
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Jeon, Y-J, Kim, T, Park, D, Nuovo, G J, Rhee, S, Joshi, P, Lee, B-K, Jeong, J, Suh, S-S, Grotzke, J E, Kim, S-H, Song, J, Sim, H, Kim, Y, Peng, Y, Jeong, Y, Garofalo, M, Zanesi, N, Kim, J, Liang, G, Nakano, I, Cresswell, P, Nana-Sinkam, P, Cui, R & Croce, C M 2018, ' miRNA-mediated TUSC3 deficiency enhances UPR and ERAD to promote metastatic potential of NSCLC ', Nature Communications, vol. 9, no. 1, pp. 5110 . https://doi.org/10.1038/s41467-018-07561-8
Nature Communications
Crossref
Dostępność :
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7959fee39af8d539bda5cccc973fa4c5
https://doaj.org/article/20aea16a00a84e518d6ba422033dbee0
Tytuł :
Circulating cell free DNA during definitive chemo-radiotherapy in non-small cell lung cancer patients – initial observations
Autorzy :
Seppo W. Langer
Jonathan W Langer
Florent Mouliere
Ivan R. Vogelius
Andreas Kjaer
Nitzan Rosenfeld
Dineika Chandrananda
Lise Barlebo Ahlborn
Lotte Nygård
Gitte F. Persson
Søren M. Bentzen
Barbara M. Fischer
Olga Østrup
Miglė Gabrielaite
Pokaż więcej
Temat :
Research Article
Medicine and health sciences
Biology and life sciences
Biochemistry
Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)
General
Medicine and Health Sciences
Oncology
Cancer Treatment
Radiation Therapy
Clinical Medicine
Clinical Oncology
Cancers and Neoplasms
Carcinomas
Squamous Cell Carcinomas
Cancer Chemotherapy
Pharmaceutics
Drug Therapy
Chemotherapy
Lung and Intrathoracic Tumors
Non-Small Cell Lung Cancer
Biology and Life Sciences
Anatomy
Body Fluids
Blood
Blood Plasma
Physiology
Adenocarcinomas
Medicine
Science
Adenocarcinoma/drug therapy
Aged
Aged, 80 and over
Antineoplastic Agents/therapeutic use
Carcinoma, Non-Small-Cell Lung/genetics
Carcinoma, Squamous Cell/drug therapy
Cell-Free Nucleic Acids/blood
Chemoradiotherapy
Female
Humans
Lung Neoplasms/genetics
Male
Middle Aged
Pilot Projects
Radiation, Ionizing
Tomography, X-Ray Computed
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Adenocarcinoma
Carcinoma, Non-Small-Cell Lung
Carcinoma, Squamous Cell
Lung Neoplasms
Antineoplastic Agents
Cell-Free Nucleic Acids
Multidisciplinary
Lung cancer
medicine.disease
medicine
Radiation therapy
medicine.medical_treatment
business.industry
business
Urology
medicine.medical_specialty
Carcinoma
Ionizing radiation
Circulating Cell-Free DNA
Blood plasma
Biochemistry, Genetics and Molecular Biology(all)
Źródło :
PLoS ONE
PLoS ONE, Vol 15, Iss 4, p e0231884 (2020)
Nygård, L, Ahlborn, L B, Persson, G F, Chandrananda, D, Langer, J W, Fischer, B M, Langer, S W, Gabrielaite, M, Kjær, A, Rosenfeld, N, Mouliere, F, Østrup, O, Vogelius, I R & Bentzen, S M 2020, ' Circulating cell free DNA during definitive chemo-radiotherapy in non-small cell lung cancer patients-initial observations ', PLoS ONE, vol. 15, no. 4, e0231884 . https://doi.org/10.1371/journal.pone.0231884
Crossref
PLoS ONE, 15(4):e0231884. Public Library of Science
Opis pliku :
application/pdf; Electronic-eCollection
Dostępność :
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf9d7c03d47711ee165c20e518db09e3
https://www.repository.cam.ac.uk/handle/1810/304848
Tytuł :
Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer
Autorzy :
Joshi, Kroopa
Robert de Massy, Marc
Ismail, Mazlina
Reading, James L.
Uddin, Imran
Woolston, Annemarie
Hatipoglu, Emine
Oakes, Theres
Rosenthal, Rachel
Peacock, Thomas
Ronel, Tahel
Noursadeghi, Mahdad
Turati, Virginia
Furness, Andrew J. S.
Georgiou, Andrew
Wong, Yien Ning Sophia
Ben Aissa, Assma
Werner Sunderland, Mariana
Jamal-Hanjani, Mariam
Veeriah, Selvaraju
Birkbak, Nicolai J.
Wilson, Gareth A.
Hiley, Crispin T.
Ghorani, Ehsan
Guerra-Assunção, José Afonso
Herrero, Javier
Enver, Tariq
Hadrup, Sine R.
Hackshaw, Allan
Peggs, Karl S.
McGranahan, Nicholas
Swanton, Charles
Quezada, Sergio A.
Chain, Benny
TRACERx Consortium
Pokaż więcej
Temat :
SDG 3 - Good Health and Well-being
General Biochemistry, Genetics and Molecular Biology
General Medicine
Cancer research
Mutation
medicine.disease_cause
medicine
CD8
Somatic cell
Nonsynonymous substitution
Phenotype
T-cell receptor
Genetic heterogeneity
Biology
Immunoediting
Article
Aged
CD8-Positive T-Lymphocytes/immunology
Carcinoma, Non-Small-Cell Lung/genetics
Female
Genetic Heterogeneity
Humans
Immunotherapy, Adoptive
Lymphocytes, Tumor-Infiltrating/immunology
Male
Middle Aged
Receptors, Antigen, T-Cell/genetics
chemical and pharmacologic phenomena
hemic and immune systems
biological factors
Źródło :
Joshi, K, Robert de Massy, M, Ismail, M, Reading, J L, Uddin, I, Woolston, A, Hatipoglu, E, Oakes, T, Rosenthal, R, Peacock, T, Ronel, T, Noursadeghi, M, Turati, V, Georgiou, A, Furness, A J S, Wong, Y N S, Ben Aissa, A, Werner Sunderland, M, Jamal-Hanjani, M, Veeriah, S, Birkbak, N J, Wilson, G A, Hiley, C T, Ghorani, E, Guerra-Assunção, J A, Herrero, J, Enver, T, Hadrup, S R, Hackshaw, A, Peggs, K S, McGranahan, N, Swanton, C, TRACERx Consortium, Quezada, S A & Chain, B 2019, ' Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer ', Nature Medicine, vol. 25, no. 10, pp. 1549-1559 . https://doi.org/10.1038/s41591-019-0592-2
Crossref
TRACERx Consortium 2019, ' Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer ', Nature Medicine, vol. 25, no. 10, pp. 1549-1559 . https://doi.org/10.1038/s41591-019-0592-2
Opis pliku :
application/pdf
Dostępność :
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56464adcefab41dfce49e7b6f0b6c6b3
https://orbit.dtu.dk/en/publications/890b91a6-cd68-47c4-914a-03044b7dbba6
Tytuł :
Absence of PD-L1 expression on tumor cells in the context of an activated immune infiltrate may indicate impaired IFNγ signaling in non-small cell lung cancer
Autorzy :
Theelen, Willemijn S. M. E.
Kuilman, Thomas
Schulze, Katja
Zou, Wei
Krijgsman, Oscar
Peters, Dennis D. G. C.
Cornelissen, Sten
Monkhorst, Kim
Sarma, Pranamee
Sumiyoshi, Teiko
Amler, Lukas C.
Willems, Stefan M.
Blaauwgeers, Johannes L. G.
van Noesel, Carel J. M.
Peeper, Daniel S.
van den Heuvel, Michel M.
Kowanetz, Marcin
Pokaż więcej
Temat :
Medicine
Science
Agricultural and Biological Sciences(all)
Biochemistry
Genetics and Molecular Biology(all)
Journal Article
Research Article
Biology and Life Sciences
Genetics
Gene Expression
Medicine and Health Sciences
Oncology
Cancers and Neoplasms
Lung and Intrathoracic Tumors
Non-Small Cell Lung Cancer
Molecular Biology
Molecular Biology Techniques
Molecular Biology Assays and Analysis Techniques
Gene Expression and Vector Techniques
Protein Expression
Research and Analysis Methods
Histochemistry and Cytochemistry Techniques
Immunohistochemistry Techniques
Immunologic Techniques
Cell biology
Cellular types
Animal cells
Blood cells
White blood cells
T cells
Cytotoxic T cells
Immune cells
Immunology
Immune Response
Mutation
Insertion Mutation
Biomarkers
Biochemistry, Genetics and Molecular Biology(all)
Adult
Aged
Aged, 80 and over
B7-H1 Antigen/genetics
CD8-Positive T-Lymphocytes/immunology
Carcinoma, Non-Small-Cell Lung/genetics
Female
Gene Expression Regulation, Neoplastic/immunology
Humans
Immunity, Cellular
Interferon-gamma/genetics
Lung Neoplasms/genetics
Male
Middle Aged
Neoplasm Proteins/genetics
Neoplasm Staging
Programmed Cell Death 1 Receptor/genetics
Signal Transduction/genetics
Multidisciplinary
Lung cancer
medicine.disease
medicine
Biology
Cancer research
Immunohistochemistry
Cytotoxic T cell
Regulation of gene expression
Cancer immunotherapy
medicine.medical_treatment
Immune system
Gene expression
CD8
80 and over
Carcinoma
Non-Small-Cell Lung/genetics
Gene Expression Regulation
Neoplastic/immunology
Immunity
Cellular
Źródło :
PLoS ONE, Vol 14, Iss 5, p e0216864 (2019)
PLoS ONE
PLoS ONE, 14(5). Public Library of Science
PLoS ONE, 14(5). PUBLIC LIBRARY SCIENCE
Crossref
PLoS ONE, 14(5):e0216864. Public Library of Science
PLoS One, 14
Opis pliku :
image/pdf; application/pdf
Dostępność :
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56c9e935a597303c8ca691ca860f905c
https://doaj.org/article/71ec07804c5045b0afac420650e42855
Tytuł :
Activity of Afatinib in Heavily Pretreated Patients With ERBB2 Mutation-Positive Advanced NSCLC: Findings From a Global Named Patient Use Program
Autorzy :
Robert M. Lorence
P. Carriere
Oliver Gautschi
Wei-Yu Liao
Jin-Yuan Shih
Vito Spataro
Hovav Nechushtan
Alessandra Curioni-Fontecedro
Gee-Chen Chang
James Chih-Hsin Yang
Solange Peters
Agnieszka Cseh
Mojca Unk
Pokaż więcej
Temat :
Adult
Afatinib/therapeutic use
Aged
Aged, 80 and over
Antineoplastic Agents/therapeutic use
Carcinoma, Non-Small-Cell Lung/drug therapy
Carcinoma, Non-Small-Cell Lung/genetics
Carcinoma, Non-Small-Cell Lung/pathology
Female
Follow-Up Studies
Humans
Lung Neoplasms/drug therapy
Lung Neoplasms/genetics
Lung Neoplasms/pathology
Male
Middle Aged
Mutation
Prognosis
Receptor, ErbB-2/genetics
Retrospective Studies
Salvage Therapy
Afatinib
ERBB2 mutation
NSCLC
Clinic for Oncology and Hematology
610 Medicine & health
Pulmonary and Respiratory Medicine
Oncology
medicine.drug
medicine
business.industry
business
Discontinuation
Erlotinib
medicine.medical_specialty
Gefitinib
Exon
Internal medicine
medicine.disease_cause
Receptor tyrosine kinase
biology.protein
biology
Disease control
neoplasms
Źródło :
Journal of thoracic oncology, vol. 13, no. 12, pp. 1897-1905
Peters, Solange; Curioni-Fontecedro, Alessandra; Nechushtan, Hovav; Shih, Jin-Yuan; Liao, Wei-Yu; Gautschi, Oliver; Spataro, Vito; Unk, Mojca; Chih-Hsin Yang, James; Lorence, Robert M; Carrière, Philippe; Cseh, Agnieszka; Chang, Gee-Chen (2018). Activity of Afatinib in Heavily Pretreated Patients With ERBB2 Mutation-Positive Advanced NSCLC: Findings From a Global Named Patient Use Program. Journal of Thoracic Oncology, 13(12):1897-1905.
Crossref
Opis pliku :
application/pdf
Dostępność :
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3a46737805b345849c87401cd2e9620
https://serval.unil.ch/notice/serval:BIB_29FF3A29D783
Tytuł :
OTX015 (MK-8628), a novel BET inhibitor, exhibits antitumor activity in non-small cell and small cell lung cancer models harboring different oncogenic mutations
Autorzy :
Maria E. Riveiro
Francesco Bertoni
Kay Noel
Ivo Kwee
Eric Raymond
Keyvan Rezai
Elodie Odore
Maurizio D'Incalci
Ramiro Vázquez
Andrea Rinaldi
Esteban Cvitkovic
Roberta Frapolli
Giorgio Inghirami
Lucile Astorgues-Xerri
Mohamed Bekradda
Pokaż więcej
Temat :
Research Paper
OTX015 (MK-8628)
bromodomain
NSCLC
SCLC
KRAS
Acetanilides/pharmacology
Animals
Antineoplastic Agents/pharmacology
Carcinoma, Non-Small-Cell Lung/drug therapy
Carcinoma, Non-Small-Cell Lung/genetics
Cell Cycle Checkpoints
Cell Line, Tumor
Cell Proliferation
Female
Gene Expression Regulation
Heterocyclic Compounds, 3-Ring/pharmacology
Humans
Lung Neoplasms/drug therapy
Lung Neoplasms/genetics
Mice
Mice, Nude
Mutation/genetics
Protein-Serine-Threonine Kinases/antagonists & inhibitors
Receptor Protein-Tyrosine Kinases/genetics
Small Cell Lung Carcinoma/drug therapy
Small Cell Lung Carcinoma/genetics
Xenograft Model Antitumor Assays
Oncology
Lymphoma
medicine.disease
medicine
Cancer research
BET inhibitor
Cancer
business.industry
business
Stem cell marker
medicine.disease_cause
Cell growth
Immunology
Anaplastic lymphoma kinase
Tumor progression
Źródło :
Oncotarget
Oncotarget, vol. 7, no. 51, pp. 84675-84687
Crossref
Opis pliku :
application/pdf
Dostępność :
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3baf689a029b4ea760bd7e7c1a28109c
http://europepmc.org/articles/PMC5354535
Tytuł :
Downregulation of SATB2 is critical for induction of epithelial-to-mesenchymal transition and invasion of NSCLC cells
Autorzy :
Hakan Kucuksayan
Osman N. Ozes
Hakan Akca
Pokaż więcej
Temat :
Cancer Research
Pulmonary and Respiratory Medicine
Oncology
CD44
biology.protein
biology
Cancer cell
Transforming growth factor beta
Immunology
Gentamicin protection assay
Homeobox protein NANOG
Cell culture
A549 cell
Epithelial–mesenchymal transition
Cancer research
Biomarkers
Carcinoma, Non-Small-Cell Lung/*genetics/*pathology
Cell Adhesion Molecules, Neuronal/*genetics
Cell Line, Tumor
Cell Transformation, Neoplastic/genetics
Epithelial-Mesenchymal Transition/*genetics
Gene Expression Regulation, Neoplastic
Gene Knockdown Techniques
Gene Silencing
Humans
Lung Neoplasms/*genetics/*pathology
Neoplasm Invasiveness
Neoplastic Stem Cells/metabolism
EMT
Invasion
NSCLC
SATB2
Stemness
TGF-β
Hermes antigen
octamer transcription factor 4
small interfering RNA
special at rich binding protein 2
transcription factor
transcription factor NANOG
transcription factor Slug
transcription factor Sox2
transcription factor Twist
transcription factor ZEB1
transforming growth factor beta
unclassified drug
biological marker
nerve cell adhesion molecule
STAB2 protein, human
A549 cell line
Article
cell culture
cell invasion
controlled study
down regulation
epithelial mesenchymal transition
fibroblast
gene silencing
human
human cell
morphology
non small cell lung cancer
priority journal
protein expression
upregulation
Western blotting
cancer stem cell
cell transformation
gene expression regulation
genetics
lung tumor
metabolism
pathology
tumor cell line
tumor invasion
Carcinoma, Non-Small-Cell Lung
Cell Adhesion Molecules, Neuronal
Cell Transformation, Neoplastic
Epithelial-Mesenchymal Transition
Lung Neoplasms
Neoplastic Stem Cells
embryonic structures
Źródło :
Crossref
Dostępność :
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10d6ee95e302bd153e61ced45b7ba3f8
https://api.elsevier.com/content/article/PII:S0169500216303580?httpAccept=text/xml
Tytuł :
Alectinib versus crizotinib in treatment-naive anaplastic lymphoma kinase-positive (ALK+) non-small-cell lung cancer: CNS efficacy results from the ALEX study
Autorzy :
Gadgeel, S
Peters, S
Mok, T
Shaw, A T
Kim, D W
Ou, S I
Pérol, M
Wrona, A
Novello, S
Rosell, R
Zeaiter, A
Liu, T
Nüesch, E
Balas, B
Camidge, D R
Pokaż więcej
Temat :
Oncology
Hematology
medicine.medical_specialty
medicine
Radiation therapy
medicine.medical_treatment
business.industry
business
Clinical endpoint
Hazard ratio
Carcinoma
medicine.disease
Internal medicine
Lung cancer
Anaplastic lymphoma kinase
Alectinib
Crizotinib
medicine.drug
Original articles
CNS tumors
alectinib
ALK-positive
CNS
NSCLC
Adult
Aged
Aged, 80 and over
Anaplastic Lymphoma Kinase/antagonists & inhibitors
Anaplastic Lymphoma Kinase/genetics
Brain/diagnostic imaging
Brain/drug effects
Brain/radiation effects
Brain Neoplasms/diagnostic imaging
Brain Neoplasms/genetics
Brain Neoplasms/secondary
Brain Neoplasms/therapy
Carbazoles/pharmacology
Carbazoles/therapeutic use
Carcinoma, Non-Small-Cell Lung/diagnostic imaging
Carcinoma, Non-Small-Cell Lung/genetics
Carcinoma, Non-Small-Cell Lung/secondary
Carcinoma, Non-Small-Cell Lung/therapy
Chemoradiotherapy/methods
Crizotinib/pharmacology
Crizotinib/therapeutic use
Disease Progression
Female
Humans
Lung/diagnostic imaging
Lung/drug effects
Lung/radiation effects
Lung Neoplasms/diagnostic imaging
Lung Neoplasms/genetics
Lung Neoplasms/pathology
Lung Neoplasms/therapy
Magnetic Resonance Imaging
Male
Middle Aged
Piperidines/pharmacology
Piperidines/therapeutic use
Treatment Outcome
Tumor Burden/drug effects
Tumor Burden/radiation effects
Young Adult
Źródło :
Crossref
Annals of Oncology
Annals of oncology, vol. 29, no. 11, pp. 2214-2222
Opis pliku :
application/pdf
Dostępność :
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::202d9467b40c9c8632a07affb6261137
Tytuł :
Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution
Autorzy :
McGranahan, Nicholas
Rosenthal, Rachel
Hiley, Crispin T.
Rowan, Andrew J.
Watkins, Thomas B.K.
Wilson, Gareth A.
Birkbak, Nicolai J.
Veeriah, Selvaraju
Van Loo, Peter
Herrero, Javier
Swanton, Charles
Jamal-Hanjani, Mariam
Shafi, Seema
Czyzewska-Khan, Justyna
Johnson, Diana
Laycock, Joanne
Bosshard-Carter, Leticia
Gorman, Pat
Hynds, Robert E.
Wilson, Gareth
Horswell, Stuart
Mitter, Richard
Escudero, Mickael
Stewart, Aengus
Rowan, Andrew
Xu, Hang
Turajlic, Samra
Hiley, Crispin
Abbosh, Christopher
Goldman, Jacki
Stone, Richard Kevin
Denner, Tamara
Matthews, Nik
Elgar, Greg
Ward, Sophia
Costa, Marta
Begum, Sharmin
Phillimore, Ben
Chambers, Tim
Nye, Emma
Graca, Sofia
Al Bakir, Maise
Joshi, Kroopa
Furness, Andrew
Ben Aissa, Assma
Wong, Yien Ning Sophia
Georgiou, Andy
Quezada, Sergio
Hartley, John A.
Lowe, Helen L.
Lawrence, David
Hayward, Martin
Panagiotopoulos, Nikolaos
Kolvekar, Shyam
Falzon, Mary
Borg, Elaine
Marafioti, Teresa
Simeon, Celia
Hector, Gemma
Smith, Amy
Aranda, Marie
Novelli, Marco
Oukrif, Dahmane
Janes, Sam M.
Thakrar, Ricky
Forster, Martin
Ahmad, Tanya
Lee, Siow Ming
Papadatos-Pastos, Dionysis
Carnell, Dawn
Mendes, Ruheena
George, Jeremy
Navani, Neal
Ahmed, Asia
Taylor, Magali
Choudhary, Junaid
Summers, Yvonne
Califano, Raffaele
Taylor, Paul
Shah, Rajesh
Krysiak, Piotr
Rammohan, Kendadai
Fontaine, Eustace
Booton, Richard
Evison, Matthew
Crosbie, Phil
Moss, Stuart
Idries, Faiza
Joseph, Leena
Bishop, Paul
Chaturved, Anshuman
Quinn, Anne Marie
Doran, Helen
Leek, Angela
Harrison, Phil
Moore, Katrina
Waddington, Rachael
Novasio, Juliette
Blackhall, Fiona
Rogan, Jane
Smith, Elaine
Dive, Caroline
Tugwood, Jonathan
Brady, Ged
Rothwell, Dominic G.
Chemi, Francesca
Pierce, Jackie
Gulati, Sakshi
Naidu, Babu
Langman, Gerald
Trotter, Simon
Bellamy, Mary
Bancroft, Hollie
Kerr, Amy
Kadiri, Salma
Webb, Joanne
Middleton, Gary
Djearaman, Madava
Fennell, Dean
Shaw, Jacqui A.
Le Quesne, John
Moore, David
Nakas, Apostolos
Rathinam, Sridhar
Monteiro, William
Marshall, Hilary
Nelson, Louise
Bennett, Jonathan
Riley, Joan
Primrose, Lindsay
Martinson, Luke
Anand, Girija
Khan, Sajid
Amadi, Anita
Nicolson, Marianne
Kerr, Keith
Palmer, Shirley
Remmen, Hardy
Miller, Joy
Buchan, Keith
Chetty, Mahendran
Gomersall, Lesley
Lester, Jason
Edwards, Alison
Morgan, Fiona
Adams, Haydn
Davies, Helen
Kornaszewska, Malgorzata
Attanoos, Richard
Lock, Sara
Verjee, Azmina
MacKenzie, Mairead
Wilcox, Maggie
Bell, Harriet
Hackshaw, Allan
Ngai, Yenting
Smith, Sean
Gower, Nicole
Ottensmeier, Christian
Chee, Serena
Johnson, Benjamin
Alzetani, Aiman
Shaw, Emily
Lim, Eric
De Sousa, Paulo
Barbosa, Monica Tavares
Bowman, Alex
Jordan, Simon
Rice, Alexandra
Raubenheimer, Hilgardt
Proli, Chiara
Cufari, Maria Elena
Ronquillo, John Carlo
Kwayie, Angela
Bhayani, Harshil
Hamilton, Morag
Bakar, Yusura
Mensah, Natalie
Ambrose, Lyn
Devaraj, Anand
Buderi, Silviu
Finch, Jonathan
Azcarate, Leire
Chavan, Hema
Green, Sophie
Mashinga, Hillaria
Nicholson, Andrew G.
Lau, Kelvin
Sheaff, Michael
Schmid, Peter
Conibear, John
Ezhil, Veni
Ismail, Babikir
Irvin-sellers, Melanie
Prakash, Vineet
Russell, Peter
Light, Teresa
Horey, Tracey
Danson, Sarah
Bury, Jonathan
Edwards, John
Hill, Jennifer
Matthews, Sue
Kitsanta, Yota
Suvarna, Kim
Fisher, Patricia
Keerio, Allah Dino
Shackcloth, Michael
Gosney, John
Postmus, Pieter
Feeney, Sarah
Asante-Siaw, Julius
Aerts, Hugo J.W.L.
Dentro, Stefan
Dessimoz, Christophe
Pokaż więcej
Temat :
General Biochemistry, Genetics and Molecular Biology
Human leukocyte antigen
Cancer
medicine.disease
medicine
Tumor Escape
Chromosome instability
Mutation
medicine.disease_cause
Biology
Immunology
Loss of heterozygosity
Immune system
Antigen presentation
Adult
Aged
Aged, 80 and over
Antigen Presentation
Carcinoma, Non-Small-Cell Lung/genetics
Carcinoma, Non-Small-Cell Lung/immunology
Carcinoma, Non-Small-Cell Lung/pathology
Carcinoma, Non-Small-Cell Lung/therapy
Cohort Studies
Female
HLA Antigens/genetics
HLA Antigens/immunology
Humans
Loss of Heterozygosity
Lung Neoplasms/genetics
Lung Neoplasms/immunology
Lung Neoplasms/pathology
Lung Neoplasms/therapy
Male
Middle Aged
Polymorphism, Single Nucleotide
bioinformatics
cancer evolution
chromosomal instability
copy number
heterogeneity
immune-editing
immune-escape
loss of heterozygosity
lung cancer
neoantigen
Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
Cell Biology
COPY NUMBER
PD-1 BLOCKADE
MUTATIONAL PROCESSES
CTLA-4 BLOCKADE
DOWN-REGULATION
CELLS
NEOANTIGENS
SENSITIVITY
RESISTANCE
DISCOVERY
Carcinoma, Non-Small-Cell Lung
HLA Antigens
Lung Neoplasms
TRACERx Consortium
06 Biological Sciences
11 Medical and Health Sciences
Developmental Biology
Article
Źródło :
Crossref
Cell, vol. 171, no. 6, pp. 1259-1271.e11
McGranahan, N, Rosenthal, R, Hiley, CT, Rowan, AJ, Watkins, TBK, Wilson, GA, Birkbak, NJ, Veeriah, S, Van Loo, P, Herrero, J, Swanton, C, Blackhall, F & Crosbie, P 2017, ' Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution ', Cell . https://doi.org/10.1016/j.cell.2017.10.001
Cell
McGranahan, N, Rosenthal, R, Hiley, C T, Rowan, A J, Watkins, T B K, Wilson, G A, Birkbak, N J, Veeriah, S, Van Loo, P, Herrero, J, Swanton, C, Jamal-Hanjani, M, Shafi, S, Czyzewska-Khan, J, Johnson, D, Laycock, J, Bosshard-Carter, L, Gorman, P, Hynds, R E, Wilson, G, Horswell, S, Mitter, R, Escudero, M, Stewart, A, Rowan, A, Xu, H, Turajlic, S, Abbosh, C, Goldman, J, Stone, R K, Denner, T, Matthews, N, Elgar, G, Ward, S, Costa, M, Begum, S, Phillimore, B, Chambers, T, Nye, E, Graca, S, Al Bakir, M, Joshi, K, Furness, A, Ben Aissa, A, Wong, Y N S, Georgiou, A, Quezada, S, Hartley, J A, Lowe, H L, Lawrence, D, Hayward, M, Panagiotopoulos, N, Kolvekar, S, Falzon, M, Borg, E, Marafioti, T, Simeon, C, Hector, G, Smith, A, Aranda, M, Novelli, M, Oukrif, D, Janes, S M, Thakrar, R, Forster, M, Ahmad, T, Lee, S M, Papadatos-Pastos, D, Carnell, D, Mendes, R, George, J, Navani, N, Ahmed, A, Taylor, M, Choudhary, J, Summers, Y, Califano, R, Taylor, P, Shah, R, Krysiak, P, Rammohan, K, Fontaine, E, Booton, R, Evison, M, Crosbie, P, Moss, S, Idries, F, Joseph, L, Bishop, P, Chaturved, A, Quinn, A M, Doran, H, Leek, A, Harrison, P, Moore, K, Waddington, R, Novasio, J, Blackhall, F, Rogan, J, Smith, E, Dive, C, Tugwood, J, Brady, G, Rothwell, D G, Chemi, F, Pierce, J, Gulati, S, Naidu, B, Langman, G, Trotter, S, Bellamy, M, Bancroft, H, Kerr, A, Kadiri, S, Webb, J, Middleton, G, Djearaman, M, Fennell, D, Shaw, J A, Le Quesne, J, Moore, D, Nakas, A, Rathinam, S, Monteiro, W, Marshall, H, Nelson, L, Bennett, J, Riley, J, Primrose, L, Martinson, L, Anand, G, Khan, S, Amadi, A, Nicolson, M, Kerr, K, Palmer, S, Remmen, H, Miller, J, Buchan, K, Chetty, M, Gomersall, L, Lester, J, Edwards, A, Morgan, F, Adams, H, Davies, H, Kornaszewska, M, Attanoos, R, Lock, S, Verjee, A, MacKenzie, M, Wilcox, M, Bell, H, Hackshaw, A, Ngai, Y, Smith, S, Gower, N, Ottensmeier, C, Chee, S, Johnson, B, Alzetani, A, Shaw, E, Lim, E, De Sousa, P, Barbosa, M T, Bowman, A, Jordan, S, Rice, A, Raubenheimer, H, Proli, C, Cufari, M E, Ronquillo, J C, Kwayie, A, Bhayani, H, Hamilton, M, Bakar, Y, Mensah, N, Ambrose, L, Devaraj, A, Buderi, S, Finch, J, Azcarate, L, Chavan, H, Green, S, Mashinga, H, Nicholson, A G, Lau, K, Sheaff, M, Schmid, P, Conibear, J, Ezhil, V, Ismail, B, Irvin-sellers, M, Prakash, V, Russell, P, Light, T, Horey, T, Danson, S, Bury, J, Edwards, J, Hill, J, Matthews, S, Kitsanta, Y, Suvarna, K, Fisher, P, Keerio, A D, Shackcloth, M, Gosney, J, Postmus, P, Feeney, S, Asante-Siaw, J, Aerts, H J W L, Dentro, S & Dessimoz, C 2017, ' Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution ', Cell, vol. 171, no. 6, pp. 1259-1271.e11 . https://doi.org/10.1016/j.cell.2017.10.001
Opis pliku :
application/pdf
Dostępność :
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a275b5e6604203ea0560773e9e9dacd
Tytuł :
Identification of recurrent FGFR3 fusion genes in lung cancer through kinome-centred RNA sequencing
Autorzy :
Wim Brugman
Jacek Niklinski
Ingrid Hofland
Ian J. Majewski
Petra M. Nederlof
Hugo M. Horlings
Lorenza Mittempergher
Dennis Peters
Astrid Bosma
Alicia Oshlack
Gerrit K J Hooijer
Ron M. Kerkhoven
Jelle Wesseling
Liliana Greger
Nico van Zandwijk
Frank Nieboer
Paul Roepman
N. Davidson
Jeroen de Jong
Alvis Brazma
Stefan M. Willems
Michel M. van den Heuvel
Iris de Rink
Jacek Jassem
Annegien Broeks
René Bernards
Roelof J C Kluin
Thomas Muley
Pokaż więcej
Temat :
Adenocarcinoma/genetics
Adenocarcinoma of Lung
Anaplastic Lymphoma Kinase
Base Sequence
Calmodulin-Binding Proteins/genetics
Carcinoma, Non-Small-Cell Lung/genetics
Carcinoma, Squamous Cell/genetics
Cohort Studies
Exons
Gene Library
High-Throughput Nucleotide Sequencing
Humans
In Situ Hybridization, Fluorescence
Lung Neoplasms/genetics
Membrane Proteins/genetics
Microtubule-Associated Proteins/genetics
Mutation
Nerve Tissue Proteins/genetics
Oncogene Proteins, Fusion/genetics
Receptor Protein-Tyrosine Kinases/genetics
Receptor, Fibroblast Growth Factor, Type 3/genetics
Sequence Analysis, RNA
Pathology and Forensic Medicine
Adenocarcinoma
medicine.disease
medicine
Lung cancer
Anaplastic lymphoma kinase
Fusion gene
Cancer
ROS1
Computational biology
Kinome
Bioinformatics
Biology
Fibroblast growth factor receptor 3
Carcinoma
Non-Small-Cell Lung/genetics
Squamous Cell/genetics
In Situ Hybridization
Fluorescence
Oncogene Proteins
Fusion/genetics
Receptor
Fibroblast Growth Factor
Type 3/genetics
Sequence Analysis
RNA
Źródło :
JOURNAL OF PATHOLOGY, 230(3), 270-6. Wiley
Crossref
Journal of pathology, 230(3), 270-276. John Wiley and Sons Ltd
Dostępność :
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::056335a634adf503bf88e4e5cba2b277
Tytuł :
Expression of ERCC1 and its clinicopathological correlations in non-small cell lung cancer
Autorzy :
Nur Büyükpınarbaşılı
Vildan Caner
Levent Elmas
G. Ozan Çetin
Gülseren Bağcı
Emre Tepeli
Füsun Düzcan
Pokaż więcej
Temat :
Genetics
Molecular Biology
General Medicine
Cisplatin
medicine.drug
medicine
Real-time polymerase chain reaction
Molecular biology
Cancer research
Nucleotide excision repair
DNA repair
Cancer
medicine.disease
ERCC1
Lung cancer
Biology
Biomarker (medicine)
Aged
Carcinoma, Non-Small-Cell Lung/*genetics/pathology
DNA, Complementary/genetics
DNA-Binding Proteins/*genetics/*metabolism
Endonucleases/*genetics/*metabolism
Female
Gene Expression Regulation, Neoplastic/*genetics
Genetic Markers/*genetics
Humans
Immunohistochemistry
Male
Middle Aged
Nucleic Acid Amplification Techniques
RNA, Messenger/*genetics
Real-Time Polymerase Chain Reaction
IHC
Non-small cell lung cancer
Real-time quantitative PCR
DNA
excision repair cross complementing protein 1
messenger RNA
aged
article
cancer staging
clinical feature
controlled study
down regulation
excision repair cross complementing group 1 gene
female
gene expression regulation
gene function
gene identification
genetic association
genetic marker
histopathology
human
human tissue
immunohistochemistry
lung non small cell cancer
major clinical study
male
molecular pathology
oncogene
protein expression
real time polymerase chain reaction
upregulation
validation process
Źródło :
Crossref
Dostępność :
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::639d35a6c14e981375eb7bff9e7cd057
http://link.springer.com/content/pdf/10.1007/s11033-011-0743-0.pdf
Tytuł :
Tumour Suppressor Pten Enhanced Enzyme Activity Of Gpx, Sod And Catalase By Suppression Of Pi3K/Akt Pathway In Non-Small Cell Lung Cancer Cell Lines
Autorzy :
Mutay Aslan
Ibrahim Acikbas
Hakan Akca
Aydın Demiray
Onur Tokgun
Pokaż więcej
Temat :
Carcinoma, Non-Small-Cell Lung/genetics/*metabolism/pathology
Catalase/metabolism
Cell Line, Tumor
Gene Expression Regulation, Neoplastic
Glutathione Peroxidase/metabolism
Humans
Lung Neoplasms/genetics/*metabolism/pathology
Oxidative Stress
PTEN Phosphohydrolase/*genetics/metabolism
Phosphatidylinositol 3-Kinases/*metabolism
Proto-Oncogene Proteins c-akt/*metabolism
Drug Discovery
Pharmacology
General Medicine
PI3K/AKT/mTOR pathway
Protein kinase B
Cancer research
Superoxide dismutase
biology.protein
biology
Glutathione peroxidase
chemistry.chemical_classification
chemistry
Cell culture
Transfection
PTEN
Tensin
Catalase
GPx
NSCLC
SOD
glutathione peroxidase
phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase
protein kinase B
superoxide dismutase
phosphatidate phosphatase
phosphatidylinositol 3 kinase
antibody labeling
article
enzyme activity
enzyme repression
gene deletion
genetic transfection
human
human cell
lung non small cell cancer
priority journal
protein expression
stable expression
transient expression
tumor suppressor gene
upregulation
Western blotting
cancer cell line
controlled study
enzyme inhibition
lung alveolus cell
non small cell lung cancer
oxidative stress
protein domain
signal transduction
Carcinoma, Non-Small-Cell Lung
Lung Neoplasms
Phosphatidylinositol 3-Kinases
Proto-Oncogene Proteins c-akt
PTEN Phosphohydrolase
Źródło :
Crossref
Opis pliku :
application/pdf
Dostępność :
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7458616b3c25156362efade2c0bf440b
https://aperta.ulakbim.gov.tr//record/16231

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