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Tytuł :
Extremely potent human monoclonal antibodies from COVID-19 convalescent patients.
Autorzy :
Andreano E; Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences, Siena, Italy.
Nicastri E; National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Rome, Italy.
Paciello I; Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences, Siena, Italy.
Pileri P; Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences, Siena, Italy.
Manganaro N; Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences, Siena, Italy.
Piccini G; VisMederi S.r.l, Siena, Italy.
Manenti A; VisMederi S.r.l, Siena, Italy; VisMederi Research S.r.l., Siena, Italy.
Pantano E; Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences, Siena, Italy.
Kabanova A; Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences, Siena, Italy; Tumour Immunology Unit, Fondazione Toscana Life Sciences, Siena, Italy.
Troisi M; Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences, Siena, Italy; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy.
Vacca F; Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences, Siena, Italy; Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy.
Cardamone D; Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences, Siena, Italy; University of Turin, Turin, Italy.
De Santi C; Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences, Siena, Italy.
Torres JL; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Ozorowski G; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Benincasa L; VisMederi Research S.r.l., Siena, Italy.
Jang H; Center for Vaccines and Immunology, University of Georgia, Athens, GA 30602, USA.
Di Genova C; Viral Pseudotype Unit, Medway School of Pharmacy, University of Kent, Chatham, UK.
Depau L; MedBiotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Brunetti J; MedBiotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Agrati C; National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Rome, Italy.
Capobianchi MR; National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Rome, Italy.
Castilletti C; National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Rome, Italy.
Emiliozzi A; Department of Medical Biotechnologies, University of Siena, Siena, Italy; Department of Medical Sciences, Infectious and Tropical Diseases Unit, University Hospital of Siena, Siena, Italy.
Fabbiani M; Department of Medical Sciences, Infectious and Tropical Diseases Unit, University Hospital of Siena, Siena, Italy.
Montagnani F; Department of Medical Biotechnologies, University of Siena, Siena, Italy; Department of Medical Sciences, Infectious and Tropical Diseases Unit, University Hospital of Siena, Siena, Italy.
Bracci L; MedBiotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena, Siena, Italy.
Sautto G; Center for Vaccines and Immunology, University of Georgia, Athens, GA 30602, USA.
Ross TM; Center for Vaccines and Immunology, University of Georgia, Athens, GA 30602, USA; Department of Infectious Diseases, University of Georgia, Athens, GA 30602, USA.
Montomoli E; VisMederi S.r.l, Siena, Italy; VisMederi Research S.r.l., Siena, Italy; Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy.
Temperton N; Viral Pseudotype Unit, Medway School of Pharmacy, University of Kent, Chatham, UK.
Ward AB; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Sala C; Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences, Siena, Italy.
Ippolito G; National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Rome, Italy.
Rappuoli R; Monoclonal Antibody Discovery (MAD) Lab, Fondazione Toscana Life Sciences, Siena, Italy; Faculty of Medicine, Imperial College, London, UK. Electronic address: .
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Źródło :
Cell [Cell] 2021 Apr 01; Vol. 184 (7), pp. 1821-1835.e16. Date of Electronic Publication: 2021 Feb 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
COVID-19*/immunology
COVID-19*/prevention & control
COVID-19*/therapy
Convalescence*
Antibodies, Monoclonal/*administration & dosage
Antibodies, Neutralizing/*administration & dosage
Antibodies, Viral/*administration & dosage
B-Lymphocytes/*immunology
3T3 Cells ; Animals ; Antibodies, Monoclonal/isolation & purification ; Antibodies, Neutralizing/isolation & purification ; Antibodies, Viral/isolation & purification ; B-Lymphocytes/cytology ; Chlorocebus aethiops ; Disease Models, Animal ; Female ; HEK293 Cells ; Humans ; Immunoglobulin Fc Fragments/immunology ; Male ; Mice ; Spike Glycoprotein, Coronavirus/immunology ; Vero Cells
Czasopismo naukowe

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