Author: "Carew RM" - OpacWWW

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Title:: Insulin receptor substrate-2 is expressed in kidney epithelium and up-regulated in diabetic nephropathy.
Authors:: Hookham MB; Centre for Vision and Vascular Science, Queen's University Belfast, UK.
O'Donovan HC
Church RH
Mercier-Zuber A
Luzi L
Curran SP
Carew RM
Droguett A
Mezzano S
Schubert M
White MF
Crean JK
Brazil DP; Show more
Source:: The FEBS journal [FEBS J] 2013 Jul; Vol. 280 (14), pp. 3232-43. Date of Electronic Publication: 2013 May 29.
Publication Type:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Gene Expression*
Diabetic Nephropathies/*metabolism
Insulin Receptor Substrate Proteins/*metabolism
Kidney Tubules/*metabolism
Adolescent ; Adult ; Animals ; Base Sequence ; Binding Sites ; Bone Morphogenetic Protein 7/physiology ; Case-Control Studies ; Cell Line ; Child ; Epithelium/metabolism ; Female ; Humans ; Insulin Receptor Substrate Proteins/genetics ; Kidney Tubules/pathology ; Male ; Mice ; Middle Aged ; Phosphorylation ; Protein Processing, Post-Translational ; Signal Transduction ; Smad4 Protein/genetics ; Transcriptional Activation ; Young Adult

Academic Journal

Go to position: 2.

Title:: Insulin receptor substrate 2 and FoxO3a signalling are involved in E-cadherin expression and transforming growth factor-β1-induced repression in kidney epithelial cells.
Authors:: Carew RM; UCD Conway Institute, University College Dublin, Belfield, Ireland.
Browne MB
Hickey FB
Brazil DP; Show more
Source:: The FEBS journal [FEBS J] 2011 Sep; Vol. 278 (18), pp. 3370-80. Date of Electronic Publication: 2011 Aug 16.
Publication Type:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Signal Transduction*
Cadherins/*metabolism
Forkhead Transcription Factors/*metabolism
Insulin Receptor Substrate Proteins/*metabolism
Kidney Tubules, Proximal/*metabolism
Transforming Growth Factor beta1/*metabolism
Antigens, CD ; Apoptosis Regulatory Proteins/metabolism ; Bcl-2-Like Protein 11 ; Cell Line, Transformed ; Cells, Cultured ; Epithelial-Mesenchymal Transition ; Forkhead Box Protein O3 ; Forkhead Transcription Factors/genetics ; Gene Expression Regulation ; Gene Silencing ; HEK293 Cells ; Humans ; Insulin Receptor Substrate Proteins/antagonists & inhibitors ; Insulin Receptor Substrate Proteins/genetics ; Kidney Glomerulus/cytology ; Kidney Glomerulus/metabolism ; Membrane Proteins/metabolism ; Mutant Proteins/genetics ; Mutant Proteins/metabolism ; Phosphorylation ; Protein Processing, Post-Translational ; Proto-Oncogene Proteins/metabolism ; RNA, Messenger/metabolism ; RNA, Small Interfering ; Superoxide Dismutase/metabolism

Academic Journal

Go to position: 3.

Title:: Deletion of Irs2 causes reduced kidney size in mice: role for inhibition of GSK3beta?
Authors:: Carew RM; UCD Diabetes Research Centre, UCD Conway Institute, School of Medicine and Medical Science, University College Dublin, Belfield Dublin 4, Ireland.
Sadagurski M
Goldschmeding R
Martin F
White MF
Brazil DP; Show more
Source:: BMC developmental biology [BMC Dev Biol] 2010 Jul 06; Vol. 10, pp. 73. Date of Electronic Publication: 2010 Jul 06.
Publication Type:: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:: Glycogen Synthase Kinase 3/*metabolism
Insulin Receptor Substrate Proteins/*metabolism
Kidney/*growth & development
Adaptor Proteins, Signal Transducing/genetics ; Animals ; Cell Cycle Proteins ; Female ; Glycogen Synthase Kinase 3 beta ; Insulin/metabolism ; Insulin Receptor Substrate Proteins/genetics ; Male ; Mice ; Organ Size ; Phosphoproteins/genetics ; Phosphorylation ; Signal Transduction ; YAP-Signaling Proteins

Academic Journal

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