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Wyszukujesz frazę ""Carnitine"" wg kryterium: Temat


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Tytuł :
Effects of in vivo phlorizin treatment and in vitro addition of carnitine, propionate, acetate, and 5-tetradecyloxy-2-furoic acid on palmitate metabolism in ovine hepatocytes.
Autorzy :
Ottemann Abbamonte CJ; Department of Animal Sciences, University of Illinois, Urbana 61801.
Overton TR; Department of Animal Sciences, University of Illinois, Urbana 61801.
Beaulieu AD; Department of Animal Sciences, University of Illinois, Urbana 61801.
Drackley JK; Department of Animal Sciences, University of Illinois, Urbana 61801. Electronic address: .
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Źródło :
Journal of dairy science [J Dairy Sci] 2021 Jul; Vol. 104 (7), pp. 7749-7760. Date of Electronic Publication: 2021 Apr 08.
Typ publikacji :
Journal Article
MeSH Terms :
Carnitine*/metabolism
Propionates*/metabolism
Acetates/metabolism ; Animals ; Carnitine O-Palmitoyltransferase/metabolism ; Fatty Acids/metabolism ; Furans ; Hepatocytes ; Liver/metabolism ; Male ; Oxidation-Reduction ; Palmitates/metabolism ; Phlorhizin/metabolism ; Phlorhizin/pharmacology ; Sheep
Czasopismo naukowe
Tytuł :
Cardiolipin Stabilizes and Increases Catalytic Efficiency of Carnitine Palmitoyltransferase II and Its Variants S113L, P50H, and Y479F.
Autorzy :
Meinhardt B; Department of Neurology, Martin-Luther-University Halle-Wittenberg, Ernst-Grube-Str. 40, 06120 Halle (Saale), Germany.
Motlagh Scholle L; Department of Neurology, Martin-Luther-University Halle-Wittenberg, Ernst-Grube-Str. 40, 06120 Halle (Saale), Germany.
Seifert F; Department of Pharmaceutical Technology and Biopharmacy, Institute of Pharmacy, Martin-Luther-University Halle-Wittenberg, Weinbergweg 22, 06120 Halle (Saale), Germany.
Anwand M; Department of Pharmaceutical Technology and Biopharmacy, Institute of Pharmacy, Martin-Luther-University Halle-Wittenberg, Weinbergweg 22, 06120 Halle (Saale), Germany.
Pietzsch M; Department of Pharmaceutical Technology and Biopharmacy, Institute of Pharmacy, Martin-Luther-University Halle-Wittenberg, Weinbergweg 22, 06120 Halle (Saale), Germany.
Zierz S; Department of Neurology, Martin-Luther-University Halle-Wittenberg, Ernst-Grube-Str. 40, 06120 Halle (Saale), Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 02; Vol. 22 (9). Date of Electronic Publication: 2021 May 02.
Typ publikacji :
Journal Article
MeSH Terms :
Cardiolipins/*metabolism
Carnitine O-Palmitoyltransferase/*genetics
Carnitine O-Palmitoyltransferase/*metabolism
Muscles/*metabolism
Carnitine ; Carnitine O-Palmitoyltransferase/deficiency ; Humans ; Kinetics ; Lipid Metabolism, Inborn Errors ; Metabolism, Inborn Errors ; Mutation
SCR Disease Name :
Carnitine palmitoyl transferase 2 deficiency
Czasopismo naukowe
Tytuł :
High L-Carnitine Levels Impede Viral Control in Chronic Hepatitis B Virus Infection.
Autorzy :
Gu S; State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Fu X; State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Ye G; State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Chen C; State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Li X; State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Zhong S; State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Tang L; State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Chen H; State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Jiang D; State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Hou J; State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Li Y; State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.
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Źródło :
Frontiers in immunology [Front Immunol] 2021 Jun 21; Vol. 12, pp. 649197. Date of Electronic Publication: 2021 Jun 21 (Print Publication: 2021).
Typ publikacji :
Journal Article; Observational Study; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*therapeutic use
Carcinoma, Hepatocellular/*immunology
Carnitine/*blood
Hepatitis B, Chronic/*immunology
Liver Neoplasms/*immunology
Adult ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; CD8-Positive T-Lymphocytes/immunology ; CD8-Positive T-Lymphocytes/metabolism ; Carcinoma, Hepatocellular/blood ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/virology ; Carnitine/metabolism ; Carnitine O-Palmitoyltransferase/genetics ; Carnitine O-Palmitoyltransferase/metabolism ; Cell Proliferation ; Cross-Sectional Studies ; Female ; Hepatitis B e Antigens/blood ; Hepatitis B e Antigens/immunology ; Hepatitis B virus/immunology ; Hepatitis B, Chronic/blood ; Hepatitis B, Chronic/drug therapy ; Hepatitis B, Chronic/virology ; Humans ; Liver Neoplasms/blood ; Liver Neoplasms/drug therapy ; Liver Neoplasms/virology ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Young Adult
Czasopismo naukowe
Tytuł :
[Analysis of a child with carnitine palmitoyl transferase 1A deficiency due to variant of CPT1A gene].
Autorzy :
Zhou Z; Department of Neurology, Hunan Children's Hospital, Changsha, Hunan 410007, China. .
Yang L
Liao H
Ning Z
Chen B
Jiang Z
Yang S
Wang M
Xiao Z
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Źródło :
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics [Zhonghua Yi Xue Yi Chuan Xue Za Zhi] 2021 Feb 10; Vol. 38 (2), pp. 184-187.
Typ publikacji :
Journal Article
MeSH Terms :
Carnitine O-Palmitoyltransferase/*deficiency
Hypoglycemia/*genetics
Lipid Metabolism, Inborn Errors/*genetics
Carnitine/blood ; Carnitine O-Palmitoyltransferase/genetics ; Child ; DNA Mutational Analysis ; Female ; Humans
SCR Disease Name :
Carnitine palmitoyl transferase 1A deficiency
Czasopismo naukowe
Tytuł :
Protective effects of L-carnitine on behavioral alterations and neuroinflammation in striatum of glutaryl-COA dehydrogenase deficient mice.
Autorzy :
Guerreiro G; Faculdade de Farmácia, UFRGS, Av. Ipiranga 2752, 90610-000, Porto Alegre, RS, Brazil; Serviço de Genética Médica, HCPA, UFRGS, Rua Ramiro Barcelos, 2350, 90035- 903, Porto Alegre, RS, Brazil. Electronic address: .
Faverzani J; Faculdade de Farmácia, UFRGS, Av. Ipiranga 2752, 90610-000, Porto Alegre, RS, Brazil; Programa de Pós-Graduação Em Ciências Farmacêuticas, UFRGS, Av. Ipiranga, 2752, 90610-000, Porto Alegre, RS, Brazil.
Moura AP; Serviço de Genética Médica, HCPA, UFRGS, Rua Ramiro Barcelos, 2350, 90035- 903, Porto Alegre, RS, Brazil.
Volfart V; Faculdade de Farmácia, UFRGS, Av. Ipiranga 2752, 90610-000, Porto Alegre, RS, Brazil.
Gome Dos Reis B; Faculdade de Farmácia, UFRGS, Av. Ipiranga 2752, 90610-000, Porto Alegre, RS, Brazil.
Sitta A; Serviço de Genética Médica, HCPA, UFRGS, Rua Ramiro Barcelos, 2350, 90035- 903, Porto Alegre, RS, Brazil.
Gonzalez EA; Programa de Pós-Graduação Em Fisiologia, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, RS, Brazil; Departamento de Microbiologia, Imunologia e Parasitologia, Instituto de Ciências Básicas da Saúde, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, RS, Brazil.
de Lima Rosa G; Programa de Pós-Graduação Em Fisiologia, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, RS, Brazil; Departamento de Microbiologia, Imunologia e Parasitologia, Instituto de Ciências Básicas da Saúde, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, RS, Brazil.
Coitinho AS; Programa de Pós-Graduação Em Fisiologia, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, RS, Brazil; Departamento de Microbiologia, Imunologia e Parasitologia, Instituto de Ciências Básicas da Saúde, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, RS, Brazil.
Baldo G; Programa de Pós-Graduação Em Fisiologia, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, RS, Brazil; Departamento de Microbiologia, Imunologia e Parasitologia, Instituto de Ciências Básicas da Saúde, Universidade Federal Do Rio Grande Do Sul, Porto Alegre, RS, Brazil.
Wajner M; Serviço de Genética Médica, HCPA, UFRGS, Rua Ramiro Barcelos, 2350, 90035- 903, Porto Alegre, RS, Brazil; Programa de Pós-Graduação Em Ciências Biológicas: Bioquímica, UFRGS, Rua Ramiro Barcelos, 2600, 90035 000, Porto Alegre, RS, Brazil.
Vargas CR; Faculdade de Farmácia, UFRGS, Av. Ipiranga 2752, 90610-000, Porto Alegre, RS, Brazil; Serviço de Genética Médica, HCPA, UFRGS, Rua Ramiro Barcelos, 2350, 90035- 903, Porto Alegre, RS, Brazil; Programa de Pós-Graduação Em Ciências Biológicas: Bioquímica, UFRGS, Rua Ramiro Barcelos, 2600, 90035 000, Porto Alegre, RS, Brazil; Programa de Pós-Graduação Em Ciências Farmacêuticas, UFRGS, Av. Ipiranga, 2752, 90610-000, Porto Alegre, RS, Brazil. Electronic address: .
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Źródło :
Archives of biochemistry and biophysics [Arch Biochem Biophys] 2021 Sep 30; Vol. 709, pp. 108970. Date of Electronic Publication: 2021 Jun 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Amino Acid Metabolism, Inborn Errors/*drug therapy
Brain Diseases, Metabolic/*drug therapy
Carnitine/*therapeutic use
Glutaryl-CoA Dehydrogenase/*deficiency
Inflammation/*drug therapy
Neuroprotective Agents/*therapeutic use
Amino Acid Metabolism, Inborn Errors/genetics ; Animals ; Brain Diseases, Metabolic/genetics ; Carnitine/analogs & derivatives ; Carnitine/metabolism ; Cathepsin D/metabolism ; Corpus Striatum/drug effects ; Corpus Striatum/metabolism ; Glutaryl-CoA Dehydrogenase/genetics ; Grooming/drug effects ; Inflammation/genetics ; Interleukin-1beta/metabolism ; Locomotion/drug effects ; Lysine/pharmacology ; Mice, Knockout ; Open Field Test/drug effects ; Transforming Growth Factor beta/metabolism
SCR Disease Name :
Glutaric Acidemia I
Czasopismo naukowe
Tytuł :
L-carnitine exerts a nutrigenomic effect via direct modulation of nuclear receptor signaling in adipocytes, hepatocytes and SKMC, demonstrating its nutritional impact.
Autorzy :
Förster L; Center for Medical Biochemistry, Division of Molecular Genetics, Max Perutz Labs, Medical University of Vienna, Vienna, Austria.
Indra D; Center for Medical Biochemistry, Division of Molecular Genetics, Max Perutz Labs, Medical University of Vienna, Vienna, Austria.
Rosenberger K; Center for Medical Biochemistry, Division of Molecular Genetics, Max Perutz Labs, Medical University of Vienna, Vienna, Austria.
Zver L; Center for Medical Biochemistry, Division of Molecular Genetics, Max Perutz Labs, Medical University of Vienna, Vienna, Austria.
Hofbauer R; Center for Medical Biochemistry, Division of Molecular Genetics, Max Perutz Labs, Medical University of Vienna, Vienna, Austria; Center for Molecular Biology, Department of Biochemistry and Cell Biology, Max Perutz Labs, University of Vienna, Vienna, Austria. Electronic address: .
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Źródło :
Nutrition research (New York, N.Y.) [Nutr Res] 2021 Jan; Vol. 85, pp. 84-98. Date of Electronic Publication: 2020 Nov 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adipocytes/*metabolism
Carnitine/*metabolism
Carnitine/*pharmacology
Cell Nucleus/*metabolism
Hepatocytes/*metabolism
Muscle Fibers, Skeletal/*metabolism
Receptors, Cytoplasmic and Nuclear/*metabolism
3T3-L1 Cells ; Animals ; Binding Sites ; Carnitine O-Acetyltransferase/genetics ; Carnitine O-Acetyltransferase/metabolism ; Cells, Cultured ; Culture Media ; Humans ; Liver X Receptors/genetics ; Mice ; Nutrigenomics ; PPAR alpha/genetics ; PPAR alpha/metabolism ; Promoter Regions, Genetic ; Receptors, Retinoic Acid/genetics ; Receptors, Retinoic Acid/metabolism ; Retinoid X Receptor alpha/genetics ; Retinoid X Receptor alpha/metabolism ; Signal Transduction ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Absolute Quantification of Acylcarnitines Using Integrated Tmt-PP Derivatization-Based LC-MS/MS and Quantitative Analysis of Multi-Components by a Single Marker Strategy.
Autorzy :
Tang T; Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing 210009, P. R. China.
Zhang P; Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing 210009, P. R. China.
Li S; Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing 210009, P. R. China.
Xu D; Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing 210009, P. R. China.
Li W; Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing 210009, P. R. China.
Tian Y; Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing 210009, P. R. China.
Jiao Y; Department of Organic Chemistry, China Pharmaceutical University, Nanjing 210009, P. R. China.
Zhang Z; Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing 210009, P. R. China.
Xu F; Key Laboratory of Drug Quality Control and Pharmacovigilance (Ministry of Education), State Key Laboratory of Natural Medicine, China Pharmaceutical University, Nanjing 210009, P. R. China.
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Źródło :
Analytical chemistry [Anal Chem] 2021 Sep 28; Vol. 93 (38), pp. 12973-12980. Date of Electronic Publication: 2021 Sep 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carnitine*/analogs & derivatives
Tandem Mass Spectrometry*
Animals ; Chromatography, Liquid ; Metabolomics ; Mice
Czasopismo naukowe
Tytuł :
Does carnitine supplementation truly increase whole-body fat oxidation in older male adults during moderate-intensity exercise?
Autorzy :
Constantin-Teodosiu D; School of Life Sciences, University of Nottingham Medical School, Nottingham, UK.
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Źródło :
Aging cell [Aging Cell] 2021 Sep; Vol. 20 (9), pp. e13449. Date of Electronic Publication: 2021 Aug 12.
Typ publikacji :
Letter; Comment
MeSH Terms :
Carnitine*
Exercise*
Adipose Tissue ; Aged ; Dietary Supplements ; Humans ; Male ; Oxidation-Reduction
Opinia redakcyjna
Tytuł :
Increased plasma and milk short-chain acylcarnitine concentrations reflect systemic LPS response in mid-lactation dairy cows.
Autorzy :
Xu W; Beijing Research Center of Intelligent Equipment for Agriculture, Beijing, People's Republic of China.
Grindler S; Faculty of Agricultural Sciences, Institute of Animal Science, University of Hohenheim, Stuttgart, Germany.
Dänicke S; Institute of Animal Nutrition, Federal Research Institute for Animal Health (Friedrich-Loeffler-Institute), Braunschweig, Germany.
Frahm J; Institute of Animal Nutrition, Federal Research Institute for Animal Health (Friedrich-Loeffler-Institute), Braunschweig, Germany.
Kenéz Á; Department of Infectious Diseases and Public Health, City University of Hong Kong, Hong Kong SAR, Hong Kong.
Huber K; Faculty of Agricultural Sciences, Institute of Animal Science, University of Hohenheim, Stuttgart, Germany.
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Źródło :
American journal of physiology. Regulatory, integrative and comparative physiology [Am J Physiol Regul Integr Comp Physiol] 2021 Sep 01; Vol. 321 (3), pp. R429-R440. Date of Electronic Publication: 2021 Jul 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carnitine/*analogs & derivatives
Lactation/*drug effects
Lipopolysaccharides/*pharmacology
Milk/*metabolism
Animals ; Carnitine/blood ; Cattle ; Diet/veterinary ; Dietary Supplements ; Energy Metabolism/drug effects ; Energy Metabolism/physiology ; Fatty Acids/metabolism ; Metabolomics/methods ; Milk/drug effects
Czasopismo naukowe
Tytuł :
Long-Chain Acyl-Carnitines Interfere with Mitochondrial ATP Production Leading to Cardiac Dysfunction in Zebrafish.
Autorzy :
Park DD; Molecular Cardiology, Department of Internal Medicine II, University of Ulm, 89081 Ulm, Germany.
Gahr BM; Molecular Cardiology, Department of Internal Medicine II, University of Ulm, 89081 Ulm, Germany.
Krause J; Clinic of Cardiology, Medical University Center Hamburg-Eppendorf, University Heart and Vascular Center Hamburg, 20251 Hamburg, Germany.
Rottbauer W; Molecular Cardiology, Department of Internal Medicine II, University of Ulm, 89081 Ulm, Germany.
Zeller T; Clinic of Cardiology, Medical University Center Hamburg-Eppendorf, University Heart and Vascular Center Hamburg, 20251 Hamburg, Germany.
Just S; Molecular Cardiology, Department of Internal Medicine II, University of Ulm, 89081 Ulm, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Aug 06; Vol. 22 (16). Date of Electronic Publication: 2021 Aug 06.
Typ publikacji :
Journal Article
MeSH Terms :
Zebrafish*/embryology
Zebrafish*/metabolism
Zebrafish*/physiology
Adenosine Triphosphate/*metabolism
Carnitine/*analogs & derivatives
Fatty Acids/*metabolism
Heart Diseases/*metabolism
Mitochondria, Heart/*metabolism
Animals ; Carnitine/metabolism ; Disease Models, Animal ; Heart/physiopathology ; Heart Diseases/pathology ; Humans ; Mitochondria, Heart/pathology ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Oxidation-Reduction
Czasopismo naukowe
Tytuł :
Metabolomics Profiling of Patients With A-β+ Ketosis-Prone Diabetes During Diabetic Ketoacidosis.
Autorzy :
Jahoor F; Children's Nutrition Research Center, Agricultural Research Service, U.S. Department of Agriculture, and Department of Pediatrics, Baylor College of Medicine, Houston, TX.
Hsu JW; Children's Nutrition Research Center, Agricultural Research Service, U.S. Department of Agriculture, and Department of Pediatrics, Baylor College of Medicine, Houston, TX.
Mehta PB; Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX.
Keene KR; Department of Emergency Medicine, Baylor College of Medicine, Houston, TX.; Ben Taub General Hospital, Harris Health System, Houston, TX.
Gaba R; Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX.; Ben Taub General Hospital, Harris Health System, Houston, TX.
Mulukutla SN; Diabetes and Endocrinology Institute, DHR Health, Edinburg, TX.
Caducoy E; Children's Nutrition Research Center, Agricultural Research Service, U.S. Department of Agriculture, and Department of Pediatrics, Baylor College of Medicine, Houston, TX.
Peacock WF; Department of Emergency Medicine, Baylor College of Medicine, Houston, TX.; Ben Taub General Hospital, Harris Health System, Houston, TX.
Patel SG; Division of Cardiothoracic Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Bennet R; Unit for Diabetes and Celiac Disease, Lund University, Malmo, Sweden.
Lernmark A; Unit for Diabetes and Celiac Disease, Lund University, Malmo, Sweden.
Balasubramanyam A; Division of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX .; Ben Taub General Hospital, Harris Health System, Houston, TX.
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Źródło :
Diabetes [Diabetes] 2021 Aug; Vol. 70 (8), pp. 1898-1909. Date of Electronic Publication: 2021 May 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Amino Acids, Branched-Chain/*blood
Carnitine/*blood
Diabetes Mellitus, Type 1/*blood
Diabetes Mellitus, Type 2/*blood
Diabetic Ketoacidosis/*blood
Adult ; Autoantibodies ; Carnitine/analogs & derivatives ; Female ; Humans ; Male ; Metabolome ; Metabolomics ; Middle Aged
Czasopismo naukowe
Tytuł :
Successful orthotopic heart transplantation in CPTII deficiency.
Autorzy :
Arnold GL; University of Pittsburgh Medical Center, USA. Electronic address: .
Yester J; University of Pittsburgh Medical Center, USA.
McCracken E; University of Pittsburgh Medical Center, USA.
Feingold BD; University of Pittsburgh Medical Center, USA.
Vockley J; University of Pittsburgh Medical Center, USA.
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Źródło :
Molecular genetics and metabolism [Mol Genet Metab] 2021 Jun; Vol. 133 (2), pp. 182-184. Date of Electronic Publication: 2021 Apr 28.
Typ publikacji :
Case Reports; Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Carnitine O-Palmitoyltransferase/*deficiency
Carnitine O-Palmitoyltransferase/*genetics
Heart/*physiopathology
Heart Transplantation/*methods
Metabolism, Inborn Errors/*therapy
Adolescent ; Adult ; Age of Onset ; Cardiomyopathies/genetics ; Cardiomyopathies/pathology ; Cardiomyopathies/therapy ; Carnitine O-Palmitoyltransferase/metabolism ; Fatty Acids/metabolism ; Humans ; Hyperammonemia/genetics ; Hyperammonemia/pathology ; Hyperammonemia/therapy ; Hypoglycemia/genetics ; Hypoglycemia/pathology ; Hypoglycemia/therapy ; Infant, Newborn ; Metabolism, Inborn Errors/genetics ; Metabolism, Inborn Errors/metabolism ; Metabolism, Inborn Errors/pathology ; Neonatal Screening ; Rhabdomyolysis/genetics ; Rhabdomyolysis/pathology ; Rhabdomyolysis/therapy ; Young Adult
SCR Disease Name :
Carnitine palmitoyl transferase 2 deficiency
Czasopismo naukowe
Tytuł :
Effects of Reducing L-Carnitine Supplementation on Carnitine Kinetics and Cardiac Function in Hemodialysis Patients: A Multicenter, Single-Blind, Placebo-Controlled, Randomized Clinical Trial.
Autorzy :
Sugiyama M; Division of Nephrology, Department of Medicine, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.; Sugi Hospital, Omuta, Fukuoka 837-0916, Japan.
Hazama T; Division of Nephrology, Department of Medicine, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
Nakano K; Division of Nephrology, Department of Medicine, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
Urae K; Division of Nephrology, Department of Medicine, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
Moriyama T; Division of Nephrology, Department of Medicine, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
Ariyoshi T; Division of Nephrology, Department of Medicine, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
Kurokawa Y; Division of Nephrology, Department of Medicine, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
Kodama G; Division of Nephrology, Department of Medicine, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
Wada Y; Wada Cardiovascular Clinic, Tosu, Saga 841-0071, Japan.
Yano J; Division of Nephrology, Department of Medicine, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.; Kurume Ekimae Clinic, Kurume, Fukuoka 830-0023, Japan.
Otsubo Y; Shin Koga Clinic, Kurume, Fukuoka 830-0033, Japan.
Iwatani R; Koga 21 Hospital, Kurume, Fukuoka 839-0801, Japan.
Kinoshita Y; Research Institute of Medical Mass Spectrometry, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
Kaida Y; Division of Nephrology, Department of Medicine, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
Nasu M; Division of Nephrology, Department of Medicine, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
Shibata R; Division of Nephrology, Department of Medicine, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
Tashiro K; Research Institute of Medical Mass Spectrometry, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
Fukami K; Division of Nephrology, Department of Medicine, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
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Źródło :
Nutrients [Nutrients] 2021 May 31; Vol. 13 (6). Date of Electronic Publication: 2021 May 31.
Typ publikacji :
Journal Article; Multicenter Study; Randomized Controlled Trial
MeSH Terms :
Dietary Supplements*
Carnitine/*blood
Carnitine/*pharmacokinetics
Heart/*drug effects
Heart Failure/*prevention & control
Kidney Failure, Chronic/*therapy
Renal Dialysis/*methods
Aged ; Carnitine/administration & dosage ; Dose-Response Relationship, Drug ; Female ; Follow-Up Studies ; Heart/physiopathology ; Heart Failure/complications ; Humans ; Kidney Failure, Chronic/blood ; Kidney Failure, Chronic/complications ; Male ; Middle Aged ; Prospective Studies ; Single-Blind Method
Czasopismo naukowe
Tytuł :
Quantitative efficacy of L-carnitine supplementation on glycemic control in type 2 diabetes mellitus patients.
Autorzy :
Wang DD; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, School of Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Mao YZ; Department of Endocrinology, Xuzhou Central Hospital, Xuzhou, Jiangsu, China.
He SM; Department of Pharmacy, The Affiliated Suzhou Science & Technology Town Hospital of Nanjing Medical University, Suzhou, Jiangsu, China.
Yang Y; Department of Pharmacy, The Affiliated Changzhou Children's Hospital of Nantong University, Changzhou, China.
Chen X; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, School of Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu, China.
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Źródło :
Expert review of clinical pharmacology [Expert Rev Clin Pharmacol] 2021 Jul; Vol. 14 (7), pp. 919-926. Date of Electronic Publication: 2021 Apr 29.
Typ publikacji :
Journal Article; Meta-Analysis; Review
MeSH Terms :
Blood Glucose/*drug effects
Carnitine/*pharmacology
Diabetes Mellitus, Type 2/*drug therapy
Carnitine/administration & dosage ; Diabetes Mellitus, Type 2/blood ; Dietary Supplements ; Glycated Hemoglobin A/metabolism ; Glycemic Control/methods ; Humans ; Time Factors
Czasopismo naukowe
Tytuł :
Surface adsorption and solution aggregation of a novel lauroyl-l-carnitine surfactant.
Autorzy :
Liu H; Biological Physics Laboratory, School of Physics and Astronomy, University of Manchester, Oxford Road, Manchester M13 9PL, UK.
Hu X; Biological Physics Laboratory, School of Physics and Astronomy, University of Manchester, Oxford Road, Manchester M13 9PL, UK.
Li Z; Biological Physics Laboratory, School of Physics and Astronomy, University of Manchester, Oxford Road, Manchester M13 9PL, UK.
Fa K; Biological Physics Laboratory, School of Physics and Astronomy, University of Manchester, Oxford Road, Manchester M13 9PL, UK.
Gong H; Biological Physics Laboratory, School of Physics and Astronomy, University of Manchester, Oxford Road, Manchester M13 9PL, UK.
Ma K; ISIS Neutron Facility, Rutherford Appleton Laboratory, STFC, Chilton, Didcot, Oxon OX11 0QX, UK.
Liao M; Biological Physics Laboratory, School of Physics and Astronomy, University of Manchester, Oxford Road, Manchester M13 9PL, UK.
Li P; ISIS Neutron Facility, Rutherford Appleton Laboratory, STFC, Chilton, Didcot, Oxon OX11 0QX, UK.
Webster JRP; ISIS Neutron Facility, Rutherford Appleton Laboratory, STFC, Chilton, Didcot, Oxon OX11 0QX, UK.
Petkov JT; Arch UK Biocides Ltd, Lonza, Hexagon Tower, Delaunays Road, Blackley, Manchester M9 8ZS, UK.
Thomas RK; Physical and Theoretical Chemistry, University of Oxford, South Parks, Oxford OX1 3QZ, UK.
Ren Lu J; Biological Physics Laboratory, School of Physics and Astronomy, University of Manchester, Oxford Road, Manchester M13 9PL, UK. Electronic address: .
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Źródło :
Journal of colloid and interface science [J Colloid Interface Sci] 2021 Jun; Vol. 591, pp. 106-114. Date of Electronic Publication: 2021 Feb 03.
Typ publikacji :
Journal Article
MeSH Terms :
Carnitine*/analogs & derivatives
Surface-Active Agents*
Adsorption ; Laurates ; Micelles ; Surface Tension
Czasopismo naukowe
Tytuł :
Evidence of a preferred kinetic pathway in the carnitine acetyltransferase reaction.
Autorzy :
Kratochvil MJ; Department of Chemistry, University of Nebraska at Kearney, Kearney, NE, 68849, USA.
Balerud NK; Department of Chemistry, University of Nebraska at Kearney, Kearney, NE, 68849, USA.
Schindler SJ; Department of Chemistry, University of Nebraska at Kearney, Kearney, NE, 68849, USA.
Moxley MA; Department of Chemistry, University of Nebraska at Kearney, Kearney, NE, 68849, USA. Electronic address: .
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Źródło :
Archives of biochemistry and biophysics [Arch Biochem Biophys] 2020 Sep 30; Vol. 691, pp. 108507. Date of Electronic Publication: 2020 Jul 22.
Typ publikacji :
Journal Article
MeSH Terms :
Carnitine O-Acetyltransferase/*chemistry
Acetyl Coenzyme A/chemistry ; Acetyl Coenzyme A/metabolism ; Animals ; Carnitine/chemistry ; Carnitine/metabolism ; Carnitine O-Acetyltransferase/metabolism ; Catalysis ; Catalytic Domain ; Coenzyme A/chemistry ; Coenzyme A/metabolism ; Columbidae ; Crystallography, X-Ray ; Kinetics ; Mice ; Protein Binding
Czasopismo naukowe
Tytuł :
The effects of exercise on skeletal and heart muscle citrate synthase and carnitine palmitoyltransferase mRNA expressions in high-calorie fed rats.
Autorzy :
Günaşti Ö; Faculty of Medicine, Department of Physiology, Division of Sports Physiology, Çukurova University, Adana, Turkey.
Özdemir Ç
Özgünen KT
Yilmaz MB
Öksüz H
Zorludemir S
Kurdak SS
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Źródło :
General physiology and biophysics [Gen Physiol Biophys] 2021 Jul; Vol. 40 (4), pp. 341-350.
Typ publikacji :
Journal Article
MeSH Terms :
Carnitine O-Palmitoyltransferase*/genetics
Muscle, Skeletal*
Animals ; Citrate (si)-Synthase ; Myocardium ; RNA, Messenger/genetics ; Rats
Czasopismo naukowe
Tytuł :
Long-Chain Acylcarnitines Decrease the Phosphorylation of the Insulin Receptor at Tyr1151 Through a PTP1B-Dependent Mechanism.
Autorzy :
Vilks K; Laboratory of Pharmaceutical Pharmacology, Latvian Institute of Organic Synthesis, Aizkraukles Str. 21, LV-1006 Riga, Latvia.; Faculty of Biology, University of Latvia, Jelgavas Str. 1, LV-1004 Riga, Latvia.
Videja M; Laboratory of Pharmaceutical Pharmacology, Latvian Institute of Organic Synthesis, Aizkraukles Str. 21, LV-1006 Riga, Latvia.; Faculty of Pharmacy, Riga Stradins University, Dzirciema Str. 16, LV-1007 Riga, Latvia.
Makrecka-Kuka M; Laboratory of Pharmaceutical Pharmacology, Latvian Institute of Organic Synthesis, Aizkraukles Str. 21, LV-1006 Riga, Latvia.
Katkevics M; Biologically Active Compound Synthesis Laboratory, Latvian Institute of Organic Synthesis, LV-1006 Riga, Latvia.
Sevostjanovs E; Laboratory of Physical Organic Chemistry, Latvian Institute of Organic Synthesis, LV-1006 Riga, Latvia.
Grandane A; Organic Synthesis Group, Latvian Institute of Organic Synthesis, LV-1006 Riga, Latvia.
Dambrova M; Laboratory of Pharmaceutical Pharmacology, Latvian Institute of Organic Synthesis, Aizkraukles Str. 21, LV-1006 Riga, Latvia.; Faculty of Pharmacy, Riga Stradins University, Dzirciema Str. 16, LV-1007 Riga, Latvia.
Liepinsh E; Laboratory of Pharmaceutical Pharmacology, Latvian Institute of Organic Synthesis, Aizkraukles Str. 21, LV-1006 Riga, Latvia.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 16; Vol. 22 (12). Date of Electronic Publication: 2021 Jun 16.
Typ publikacji :
Journal Article
MeSH Terms :
Carnitine/*analogs & derivatives
Phosphorylation/*drug effects
Protein Tyrosine Phosphatase, Non-Receptor Type 1/*metabolism
Receptor, Insulin/*metabolism
Tyrosine/*metabolism
Animals ; CHO Cells ; Carnitine/pharmacology ; Cricetulus ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Insulin/metabolism ; Insulin Resistance ; Models, Biological ; Protein Phosphatase 2/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Receptor, Insulin/chemistry
Czasopismo naukowe
Tytuł :
Exacerbation of cardiovascular ageing by diabetes mellitus and its associations with acyl-carnitines.
Autorzy :
Gao F; National Heart Centre Singapore, Singapore.; Duke-NUS Medical School, Singapore.
Kovalik JP; Duke-NUS Medical School, Singapore.; Singapore General Hospital, Singapore.
Zhao X; National Heart Centre Singapore, Singapore.
Chow VJ; National Heart Centre Singapore, Singapore.
Chew H; National Heart Centre Singapore, Singapore.
Teo LL; National Heart Centre Singapore, Singapore.; Duke-NUS Medical School, Singapore.
Tan RS; National Heart Centre Singapore, Singapore.; Duke-NUS Medical School, Singapore.
Leng S; National Heart Centre Singapore, Singapore.
Ewe SH; National Heart Centre Singapore, Singapore.; Duke-NUS Medical School, Singapore.
Tan HC; Duke-NUS Medical School, Singapore.; Singapore General Hospital, Singapore.
Tan TY; Duke-NUS Medical School, Singapore.
Lee LS; Duke-NUS Medical School, Singapore.
Ching J; Duke-NUS Medical School, Singapore.; KK Research Centre, KK Women's and Children's Hospital, Singapore.
Keng BM; National Heart Centre Singapore, Singapore.
Zhong L; National Heart Centre Singapore, Singapore.; Duke-NUS Medical School, Singapore.
Koh WP; Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Koh AS; National Heart Centre Singapore, Singapore.; Duke-NUS Medical School, Singapore.
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Źródło :
Aging [Aging (Albany NY)] 2021 Jun 04; Vol. 13 (11), pp. 14785-14805. Date of Electronic Publication: 2021 Jun 04.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Aging/*pathology
Cardiovascular System/*pathology
Carnitine/*analogs & derivatives
Diabetes Mellitus/*pathology
Aged ; Cardiovascular System/physiopathology ; Carnitine/metabolism ; Diabetes Mellitus/physiopathology ; Female ; Humans ; Male ; Middle Aged
Czasopismo naukowe
Tytuł :
L-carnitine suppresses transient receptor potential vanilloid type 1 activity and myofibroblast transdifferentiation in human corneal keratocytes.
Autorzy :
Turan E; Klinik für Augenheilkunde, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.
Valtink M; Institute of Anatomy, Faculty of Medicine Carl Gustav Carus of the TU Dresden, Dresden, Germany.
Reinach PS; School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, PR China.
Skupin A; Institute of Anatomy, Faculty of Medicine Carl Gustav Carus of the TU Dresden, Dresden, Germany.
Luo H; Klinik für Augenheilkunde, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.
Brockmann T; Klinik für Augenheilkunde, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.; Berlin Institute of Health (BIH), Kapelle-Ufer 2, 10117, Berlin, Germany.; Department of Ophthalmology, Universitätsmedizin Rostock, Rostock, Germany.
Ba Salem MHO; Klinik für Augenheilkunde, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.
Pleyer U; Klinik für Augenheilkunde, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.
Mergler S; Klinik für Augenheilkunde, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany. .
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Źródło :
Laboratory investigation; a journal of technical methods and pathology [Lab Invest] 2021 Jun; Vol. 101 (6), pp. 680-689. Date of Electronic Publication: 2021 Feb 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carnitine/*therapeutic use
Cell Transdifferentiation/*drug effects
Corneal Keratocytes/*drug effects
Corneal Stroma/*drug effects
TRPV Cation Channels/*metabolism
Carnitine/pharmacology ; Cells, Cultured ; Corneal Stroma/cytology ; Drug Evaluation, Preclinical ; Humans ; Myofibroblasts ; TRPV Cation Channels/drug effects
Czasopismo naukowe

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