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Wyświetlanie 1-15 z 15
Tytuł:
Modeling and optimization of parallelized immunomagnetic nanopore sorting for surface marker specific isolation of extracellular vesicles from complex media.
Autorzy:
Lin AA; Department of Bioengineering, University of Pennsylvania, 210 S. 33rd St., Philadelphia, PA, 19104, USA.; Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd., Philadelphia, PA, 19104, USA.
Shen H; Department of Bioengineering, University of Pennsylvania, 210 S. 33rd St., Philadelphia, PA, 19104, USA.
Spychalski G; Department of Bioengineering, University of Pennsylvania, 210 S. 33rd St., Philadelphia, PA, 19104, USA.; Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd., Philadelphia, PA, 19104, USA.
Carpenter EL; Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd., Philadelphia, PA, 19104, USA.
Issadore D; Department of Bioengineering, University of Pennsylvania, 210 S. 33rd St., Philadelphia, PA, 19104, USA. .
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Źródło:
Scientific reports [Sci Rep] 2023 Aug 16; Vol. 13 (1), pp. 13292. Date of Electronic Publication: 2023 Aug 16.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Nanopores*
Extracellular Vesicles*
Liver Neoplasms*
Humans ; Cell Movement ; Computer Simulation
Czasopismo naukowe
Tytuł:
Transcriptional profiling of single tumour cells from pleural effusions reveals heterogeneity of epithelial to mesenchymal transition and extra-cellular matrix marker expression.
Autorzy:
Sen M; Department of Medicine, Division of Hematology and Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Hausler RM; Department of Medicine, Division of Hematology and Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Dulmage K; Life Science Innovation, BD Technologies and Innovations, Durham, North Carolina, USA.
Black TA; Department of Medicine, Division of Hematology and Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Murphy W; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Pletcher CH Jr; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Wang L; Life Science Innovation, BD Technologies and Innovations, Durham, North Carolina, USA.
Chen C; Life Science Innovation, BD Technologies and Innovations, Durham, North Carolina, USA.
Yee SS; Department of Medicine, Division of Hematology and Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Bornheimer SJ; BD Biosciences, San Jose, California, USA.
Maxwell KN; Department of Medicine, Division of Hematology and Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Stanger BZ; Department of Medicine, Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Moore JS; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Thompson JC; Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Thoracic Oncology Group, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Carpenter EL; Department of Medicine, Division of Hematology and Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
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Źródło:
Clinical and translational medicine [Clin Transl Med] 2022 Jul; Vol. 12 (7), pp. e888.
Typ publikacji:
Letter; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Pleural Effusion*
Pleural Effusion, Malignant*/genetics
Pleural Effusion, Malignant*/metabolism
Pleural Effusion, Malignant*/pathology
Epithelial-Mesenchymal Transition/genetics ; Humans
Raport
Tytuł:
Development of a robust radiomic biomarker of progression-free survival in advanced non-small cell lung cancer patients treated with first-line immunotherapy.
Autorzy:
Singh A; Department of Radiology, Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Rm D702 Richards Bldg., 3700 Hamilton Walk, Philadelphia, PA, 19104, USA.; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Horng H; Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Roshkovan L; Department of Radiology, Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Rm D702 Richards Bldg., 3700 Hamilton Walk, Philadelphia, PA, 19104, USA.
Weeks JK; Department of Radiology, Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Rm D702 Richards Bldg., 3700 Hamilton Walk, Philadelphia, PA, 19104, USA.
Hershman M; Department of Radiology, Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Rm D702 Richards Bldg., 3700 Hamilton Walk, Philadelphia, PA, 19104, USA.
Noël P; Department of Radiology, Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Rm D702 Richards Bldg., 3700 Hamilton Walk, Philadelphia, PA, 19104, USA.
Luna JM; Department of Radiology, Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Rm D702 Richards Bldg., 3700 Hamilton Walk, Philadelphia, PA, 19104, USA.
Cohen EA; Department of Radiology, Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Rm D702 Richards Bldg., 3700 Hamilton Walk, Philadelphia, PA, 19104, USA.
Pantalone L; Department of Radiology, Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Rm D702 Richards Bldg., 3700 Hamilton Walk, Philadelphia, PA, 19104, USA.
Shinohara RT; Department of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Bauml JM; Department of Medicine, Division of Hematology-Oncology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Thompson JC; Department of Medicine, Division of Hematology-Oncology, University of Pennsylvania, Philadelphia, PA, 19104, USA.; Department of Medicine, Pulmonary, Allergy and Critical Care Medicine, Thoracic Oncology Group, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Aggarwal C; Department of Medicine, Division of Hematology-Oncology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Carpenter EL; Department of Medicine, Division of Hematology-Oncology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Katz SI; Department of Radiology, Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Rm D702 Richards Bldg., 3700 Hamilton Walk, Philadelphia, PA, 19104, USA.
Kontos D; Department of Radiology, Center for Biomedical Image Computing and Analytics (CBICA), University of Pennsylvania, Rm D702 Richards Bldg., 3700 Hamilton Walk, Philadelphia, PA, 19104, USA. .
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Źródło:
Scientific reports [Sci Rep] 2022 Jun 15; Vol. 12 (1), pp. 9993. Date of Electronic Publication: 2022 Jun 15.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Carcinoma, Non-Small-Cell Lung*/diagnostic imaging
Carcinoma, Non-Small-Cell Lung*/drug therapy
Lung Neoplasms*/diagnostic imaging
Lung Neoplasms*/drug therapy
Biomarkers ; Humans ; Immunotherapy/methods ; Progression-Free Survival
Czasopismo naukowe
Tytuł:
NRF2 and Key Transcriptional Targets in Melanoma Redox Manipulation.
Autorzy:
Carpenter EL; Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR 97331, USA.
Becker AL; Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR 97331, USA.; John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA.
Indra AK; Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR 97331, USA.; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.; Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR 97331, USA.; Linus Pauling Science Center, Oregon State University, Corvallis, OR 97331, USA.; Department of Dermatology, Oregon Health & Science University, Portland, OR 97239, USA.
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Źródło:
Cancers [Cancers (Basel)] 2022 Mar 16; Vol. 14 (6). Date of Electronic Publication: 2022 Mar 16.
Typ publikacji:
Journal Article; Review
Czasopismo naukowe
Tytuł:
Impact of Interobserver Variability in Manual Segmentation of Non-Small Cell Lung Cancer (NSCLC) Applying Low-Rank Radiomic Representation on Computed Tomography.
Autorzy:
Hershman M; Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Yousefi B; Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.; Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Serletti L; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Galperin-Aizenberg M; Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Roshkovan L; Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Luna JM; Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.; Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Thompson JC; Section of Interventional Pulmonology, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Aggarwal C; Division of Hematology and Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Carpenter EL; Division of Hematology and Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Kontos D; Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.; Center for Biomedical Image Computing and Analytics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Katz SI; Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA.
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Źródło:
Cancers [Cancers (Basel)] 2021 Nov 28; Vol. 13 (23). Date of Electronic Publication: 2021 Nov 28.
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Combining radiomic phenotypes of non-small cell lung cancer with liquid biopsy data may improve prediction of response to EGFR inhibitors.
Autorzy:
Yousefi B; Department of Radiology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
LaRiviere MJ; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Cohen EA; Department of Radiology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Buckingham TH; Division of Hematology and Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Yee SS; Division of Hematology and Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Black TA; Division of Hematology and Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Chien AL; Division of Hematology and Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Noël P; Department of Radiology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Hwang WT; Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Katz SI; Department of Radiology, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Aggarwal C; Division of Hematology and Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Thompson JC; Section of Interventional Pulmonology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Carpenter EL; Division of Hematology and Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Kontos D; Department of Radiology, University of Pennsylvania, Philadelphia, PA, 19104, USA. .; Computational Biomarker Imaging Group (CBIG), Department of Radiology, University of Pennsylvania, Rm D702 Richards Bldg., 3700 Hamilton Walk, Philadelphia, PA, 19104, USA. .
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Źródło:
Scientific reports [Sci Rep] 2021 May 11; Vol. 11 (1), pp. 9984. Date of Electronic Publication: 2021 May 11.
Typ publikacji:
Journal Article; Observational Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Genes, erbB-1*
Image Processing, Computer-Assisted*
Tomography, X-Ray Computed*
Carcinoma, Non-Small-Cell Lung/*diagnostic imaging
Lung Neoplasms/*diagnostic imaging
Aged ; Aged, 80 and over ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; Circulating Tumor DNA/analysis ; ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/genetics ; Feasibility Studies ; Female ; Humans ; Liquid Biopsy ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Male ; Middle Aged ; Pharmacogenomic Variants ; Phenotype ; Retrospective Studies
Czasopismo naukowe
Tytuł:
Using an interprofessional team to provide refugee healthcare in an academic medical centre.
Autorzy:
Elmore CE; Department of Family Medicine, University of Virginia Health System, Charlottesville, Virginia, USA.
Tingen JM; Department of Family Medicine, University of Virginia Health System, Charlottesville, Virginia, USA.; Department of Pharmacy Services, University of Virginia Health System, Charlottesville, Virginia, USA.
Fredgren K; Department of Social Work, University of Virginia Health System, Charlottesville, Virginia, USA.
Dalrymple SN; Department of Family Medicine, University of Virginia Health System, Charlottesville, Virginia, USA.
Compton RM; Department of Family Medicine, University of Virginia Health System, Charlottesville, Virginia, USA.
Carpenter EL; Department of Family Medicine, University of Virginia Health System, Charlottesville, Virginia, USA.
Allen CW; Department of Family Medicine, University of Virginia Health System, Charlottesville, Virginia, USA.
Hauck FR; Department of Family Medicine, University of Virginia Health System, Charlottesville, Virginia, USA.; Department of Public Health Sciences, University of Virginia Health System, Charlottesville, Virginia, USA.
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Źródło:
Family medicine and community health [Fam Med Community Health] 2019 Jul 11; Vol. 7 (3), pp. e000091. Date of Electronic Publication: 2019 Jul 11 (Print Publication: 2019).
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
An integrated flow cytometry-based platform for isolation and molecular characterization of circulating tumor single cells and clusters.
Autorzy:
Bhagwat N; Division of Gastroenterology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Dulmage K; BD Technologies and Innovation, Research Triangle Park, NC, USA.
Pletcher CH Jr; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Wang L; BD Technologies and Innovation, Research Triangle Park, NC, USA.
DeMuth W; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Sen M; Division of Hematology and Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Balli D; Division of Gastroenterology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Yee SS; Division of Hematology and Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Sa S; BD Biosciences, San Jose, CA, USA.
Tong F; BD Technologies and Innovation, Research Triangle Park, NC, USA.
Yu L; BD Biosciences, San Jose, CA, USA.
Moore JS; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Stanger BZ; Division of Gastroenterology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Dixon EP; BD Technologies and Innovation, Research Triangle Park, NC, USA.
Carpenter EL; Division of Hematology and Oncology, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. .
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Źródło:
Scientific reports [Sci Rep] 2018 Mar 22; Vol. 8 (1), pp. 5035. Date of Electronic Publication: 2018 Mar 22.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Validation Study
MeSH Terms:
Neoplastic Cells, Circulating/*metabolism
Pancreatic Neoplasms/*pathology
Single-Cell Analysis/*methods
Animals ; Cell Line, Tumor/transplantation ; Cell Separation/methods ; Disease Models, Animal ; Flow Cytometry/methods ; Gene Expression Profiling/methods ; Humans ; Leukocyte Reduction Procedures/instrumentation ; Leukocyte Reduction Procedures/methods ; Liquid Biopsy/methods ; Magnets ; Mice ; Pancreatic Neoplasms/blood ; Pancreatic Neoplasms/genetics
Czasopismo naukowe
Tytuł:
Feasibility of monitoring advanced melanoma patients using cell-free DNA from plasma.
Autorzy:
Gangadhar TC; Division of Hematology/Oncology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Savitch SL; Division of Hematology/Oncology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Yee SS; Division of Hematology/Oncology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Xu W; Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Huang AC; Division of Hematology/Oncology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Institue for Immunology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Parker Institute of Immunotherapy, University of Pennsylvania, Philadelphia, PA, USA.
Harmon S; Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Lieberman DB; Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Soucier D; Division of Hematology/Oncology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Fan R; Division of Hematology/Oncology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Black TA; Division of Hematology/Oncology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Morrissette JJD; Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Salathia N; Illumina Inc., San Diego, CA, USA.
Waters J; Illumina Inc., San Diego, CA, USA.
Zhang S; Illumina Inc., San Diego, CA, USA.
Toung J; Grail Bio, Redwood City, CA, USA.
van Hummelen P; Illumina Inc., San Diego, CA, USA.
Fan JB; Illumina Inc., San Diego, CA, USA.
Xu X; Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Amaravadi RK; Division of Hematology/Oncology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Schuchter LM; Division of Hematology/Oncology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Karakousis GC; Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Hwang WT; Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Department of Biostatistics & Epidemiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Carpenter EL; Division of Hematology/Oncology, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
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Źródło:
Pigment cell & melanoma research [Pigment Cell Melanoma Res] 2018 Jan; Vol. 31 (1), pp. 73-81. Date of Electronic Publication: 2017 Oct 23.
Typ publikacji:
Clinical Trial; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Mutation*
Biomarkers, Tumor/*genetics
Cell-Free Nucleic Acids/*genetics
Melanoma/*diagnosis
Skin Neoplasms/*diagnosis
Biomarkers, Tumor/blood ; Cell-Free Nucleic Acids/blood ; Feasibility Studies ; Female ; High-Throughput Nucleotide Sequencing ; Humans ; Male ; Melanoma/blood ; Melanoma/genetics ; Middle Aged ; Pilot Projects ; Skin Neoplasms/blood ; Skin Neoplasms/genetics
Czasopismo naukowe
Tytuł:
Ablation of epidermal RXRα in cooperation with activated CDK4 and oncogenic NRAS generates spontaneous and acute neonatal UVB induced malignant metastatic melanomas.
Autorzy:
Chagani S; Molecular and Cellular Biology Program, OSU, Corvallis, 97331, OR, USA.; Department of Pharmaceutical Sciences, College of Pharmacy, OSU, Corvallis, 97331, OR, USA.
Wang R; Department of Pharmaceutical Sciences, College of Pharmacy, OSU, Corvallis, 97331, OR, USA.; Linus Pauling Institute, OSU, Corvallis, OR, USA.
Carpenter EL; Department of Pharmaceutical Sciences, College of Pharmacy, OSU, Corvallis, 97331, OR, USA.
Löhr CV; College of Veterinary Medicine, Oregon State University, Corvallis, Oregon, 97331, USA.
Ganguli-Indra G; Molecular and Cellular Biology Program, OSU, Corvallis, 97331, OR, USA.; Department of Pharmaceutical Sciences, College of Pharmacy, OSU, Corvallis, 97331, OR, USA.; Knight Cancer Institute, Oregon Health & Science University (OHSU), Portland, 97239, OR, USA.
Indra AK; Molecular and Cellular Biology Program, OSU, Corvallis, 97331, OR, USA. .; Department of Pharmaceutical Sciences, College of Pharmacy, OSU, Corvallis, 97331, OR, USA. .; Linus Pauling Institute, OSU, Corvallis, OR, USA. .; Knight Cancer Institute, Oregon Health & Science University (OHSU), Portland, 97239, OR, USA. .; Department of Dermatology, OHSU, Portland, 97239, OR, USA. .
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Źródło:
BMC cancer [BMC Cancer] 2017 Nov 09; Vol. 17 (1), pp. 736. Date of Electronic Publication: 2017 Nov 09.
Typ publikacji:
Journal Article
MeSH Terms:
Ablation Techniques/*methods
Cyclin-Dependent Kinase 4/*metabolism
GTP Phosphohydrolases/*metabolism
Melanoma/*metabolism
Membrane Proteins/*metabolism
Retinoid X Receptor alpha/*deficiency
Skin Neoplasms/*metabolism
Ultraviolet Rays/*adverse effects
Acute Disease ; Animals ; Animals, Newborn ; Carcinogenesis/pathology ; Carcinogenesis/radiation effects ; Male ; Melanoma/etiology ; Melanoma/pathology ; Mice ; Mice, Knockout ; Mice, Transgenic ; Skin Neoplasms/etiology ; Skin Neoplasms/pathology ; Melanoma, Cutaneous Malignant
Czasopismo naukowe
Tytuł:
A novel approach for next-generation sequencing of circulating tumor cells.
Autorzy:
Yee SS; Department of Medicine University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania.
Lieberman DB; Department of Pathology and Laboratory Medicine Hospital of the University of Pennsylvania Philadelphia Pennsylvania.
Blanchard T; Department of Cancer BiologyUniversity of Pennsylvania Perelman School of MedicinePhiladelphiaPennsylvania; Abramson Family Cancer Research InstituteUniversity of Pennsylvania Perelman School of MedicinePhiladelphiaPennsylvania.
Rader J; Division of Oncology Center for Childhood Cancer Research Children's Hospital of Philadelphia Philadelphia Pennsylvania.
Zhao J; Department of Pathology and Laboratory Medicine Hospital of the University of Pennsylvania Philadelphia Pennsylvania.
Troxel AB; Center for Clinical Epidemiology and BiostatisticsUniversity of PennsylvaniaPhiladelphiaPennsylvania; Abramson Cancer CenterUniversity of Pennsylvania Perelman School of MedicinePhiladelphiaPennsylvania.
DeSloover D; Department of Pathology and Laboratory Medicine Hospital of the University of Pennsylvania Philadelphia Pennsylvania.
Fox AJ; Department of Pathology and Laboratory Medicine Hospital of the University of Pennsylvania Philadelphia Pennsylvania.
Daber RD; Department of Pathology and Laboratory Medicine Hospital of the University of Pennsylvania Philadelphia Pennsylvania.
Kakrecha B; Department of Medicine University of Pennsylvania Perelman School of Medicine Philadelphia Pennsylvania.
Sukhadia S; Department of Pathology and Laboratory Medicine Hospital of the University of Pennsylvania Philadelphia Pennsylvania.
Belka GK; Department of Cancer BiologyUniversity of Pennsylvania Perelman School of MedicinePhiladelphiaPennsylvania; Abramson Family Cancer Research InstituteUniversity of Pennsylvania Perelman School of MedicinePhiladelphiaPennsylvania.
DeMichele AM; Department of MedicineUniversity of Pennsylvania Perelman School of MedicinePhiladelphiaPennsylvania; Abramson Cancer CenterUniversity of Pennsylvania Perelman School of MedicinePhiladelphiaPennsylvania.
Chodosh LA; Department of MedicineUniversity of Pennsylvania Perelman School of MedicinePhiladelphiaPennsylvania; Department of Cancer BiologyUniversity of Pennsylvania Perelman School of MedicinePhiladelphiaPennsylvania; Abramson Family Cancer Research InstituteUniversity of Pennsylvania Perelman School of MedicinePhiladelphiaPennsylvania.
Morrissette JJ; Department of Pathology and Laboratory Medicine Hospital of the University of Pennsylvania Philadelphia Pennsylvania.
Carpenter EL; Department of MedicineUniversity of Pennsylvania Perelman School of MedicinePhiladelphiaPennsylvania; Abramson Cancer CenterUniversity of Pennsylvania Perelman School of MedicinePhiladelphiaPennsylvania.
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Źródło:
Molecular genetics & genomic medicine [Mol Genet Genomic Med] 2016 Feb 28; Vol. 4 (4), pp. 395-406. Date of Electronic Publication: 2016 Feb 28 (Print Publication: 2016).
Typ publikacji:
Journal Article
Czasopismo naukowe
Tytuł:
Antibody targeting of anaplastic lymphoma kinase induces cytotoxicity of human neuroblastoma.
Autorzy:
Carpenter EL; Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Haglund EA
Mace EM
Deng D
Martinez D
Wood AC
Chow AK
Weiser DA
Belcastro LT
Winter C
Bresler SC
Vigny M
Mazot P
Asgharzadeh S
Seeger RC
Zhao H
Guo R
Christensen JG
Orange JS
Pawel BR
Lemmon MA
Mossé YP
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Źródło:
Oncogene [Oncogene] 2012 Nov 15; Vol. 31 (46), pp. 4859-67. Date of Electronic Publication: 2012 Jan 23.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms:
Antibodies, Monoclonal/*immunology
Antibodies, Monoclonal/*pharmacology
Neuroblastoma/*immunology
Neuroblastoma/*therapy
Receptor Protein-Tyrosine Kinases/*antagonists & inhibitors
Receptor Protein-Tyrosine Kinases/*immunology
Anaplastic Lymphoma Kinase ; Antigens, Neoplasm/genetics ; Antigens, Neoplasm/immunology ; Antigens, Neoplasm/metabolism ; Cell Death/drug effects ; Cell Death/genetics ; Cell Death/immunology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Crizotinib ; Humans ; Mutation/immunology ; Neuroblastoma/genetics ; Neuroblastoma/metabolism ; Phosphorylation ; Protein Kinase Inhibitors/pharmacology ; Protein-Tyrosine Kinases/genetics ; Protein-Tyrosine Kinases/immunology ; Protein-Tyrosine Kinases/metabolism ; Proto-Oncogene Proteins c-met/antagonists & inhibitors ; Pyrazoles/pharmacology ; Pyridines/pharmacology ; Receptor Protein-Tyrosine Kinases/genetics ; Receptor Protein-Tyrosine Kinases/metabolism ; Signal Transduction/drug effects ; Signal Transduction/immunology
Czasopismo naukowe
Tytuł:
Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma.
Autorzy:
Diskin SJ; Division of Oncology, Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Capasso M
Schnepp RW
Cole KA
Attiyeh EF
Hou C
Diamond M
Carpenter EL
Winter C
Lee H
Jagannathan J
Latorre V
Iolascon A
Hakonarson H
Devoto M
Maris JM
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Źródło:
Nature genetics [Nat Genet] 2012 Oct; Vol. 44 (10), pp. 1126-30. Date of Electronic Publication: 2012 Sep 02.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Polymorphism, Single Nucleotide*
DNA-Binding Proteins/*genetics
Neuroblastoma/*genetics
Ubiquitin-Protein Ligases/*genetics
Case-Control Studies ; Cell Line, Tumor ; Cell Proliferation ; Chromosomes, Human, Pair 6 ; Cohort Studies ; DNA-Binding Proteins/metabolism ; Gene Expression ; Gene Frequency ; Gene Knockdown Techniques ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Infant ; Kaplan-Meier Estimate ; Linkage Disequilibrium ; Neuroblastoma/metabolism ; Neuroblastoma/mortality ; Oligonucleotide Array Sequence Analysis ; RNA Interference ; RNA-Binding Proteins ; Sequence Analysis, DNA ; Transcriptome ; Ubiquitin-Protein Ligases/metabolism
Czasopismo naukowe
Tytuł:
Activation of human B cells by the agonist CD40 antibody CP-870,893 and augmentation with simultaneous toll-like receptor 9 stimulation.
Autorzy:
Carpenter EL; Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. />Mick R
Rüter J
Vonderheide RH
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Źródło:
Journal of translational medicine [J Transl Med] 2009 Nov 11; Vol. 7, pp. 93. Date of Electronic Publication: 2009 Nov 11.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Antibodies, Monoclonal/*pharmacology
B-Lymphocytes/*drug effects
CD40 Antigens/*agonists
Toll-Like Receptor 9/*immunology
Animals ; Antibodies, Monoclonal/immunology ; Antibodies, Monoclonal, Humanized ; B-Lymphocytes/immunology ; CD40 Antigens/immunology ; Humans ; Immunologic Memory/drug effects ; Immunologic Memory/immunology ; Lymphocyte Activation/drug effects ; Lymphocyte Activation/immunology ; Mice ; Neoplasms/immunology ; T-Lymphocytes/drug effects ; T-Lymphocytes/immunology
Czasopismo naukowe
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