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Tytuł:
Upregulated expression of miR-4443 and miR-4488 in drug resistant melanomas promotes migratory and invasive phenotypes through downregulation of intermediate filament nestin.
Autorzy:
Castaldo V; Department of Anatomy, Histology, Forensic- Medicine and Orthopedics, Sapienza University of Rome, 00161, Rome, Italy.
Minopoli M; Preclinical Models of Tumor Progression Unit, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', 80131, Naples, Italy.
Di Modugno F; Tumor Immunology and Immunotherapy Unit, IRCCS Regina Elena National Cancer Institute, 00144, Rome, Italy.
Sacconi A; Clinical Trial Center, Biostatistics and Bioinformatics Unit, IRCCS Regina Elena National Cancer Institute, 00144, Rome, Italy.
Liguoro D; Department of Clinical and Molecular Medicine, Sapienza University of Rome, 00161, Rome, Italy.
Frigerio R; SAFU Laboratory, Department of Research, Advanced Diagnostics and Technological Innovation, Translational Research Area, IRCCS Regina Elena National Cancer Institute, 00144, Rome, Italy.
Ortolano A; SAFU Laboratory, Department of Research, Advanced Diagnostics and Technological Innovation, Translational Research Area, IRCCS Regina Elena National Cancer Institute, 00144, Rome, Italy.
Di Martile M; Preclinical Models and New Therapeutic Agents Unit, IRCCS Regina Elena National Cancer Institute, 00144, Rome, Italy.
Gesualdi L; Department of Anatomy, Histology, Forensic- Medicine and Orthopedics, Sapienza University of Rome, 00161, Rome, Italy.
Madonna G; Unit of Melanoma, Cancer Immunotherapy and Development Therapeutics, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', 80131, Naples, Italy.
Capone M; Unit of Melanoma, Cancer Immunotherapy and Development Therapeutics, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', 80131, Naples, Italy.
Cirombella R; Faculty of Medicine and Psychology, Department Clinical and Molecular Medicine, Sant'Andrea Hospital, Sapienza University of Rome, 00118, Rome, Italy.
Catizone A; Department of Anatomy, Histology, Forensic- Medicine and Orthopedics, Sapienza University of Rome, 00161, Rome, Italy.
Del Bufalo D; Preclinical Models and New Therapeutic Agents Unit, IRCCS Regina Elena National Cancer Institute, 00144, Rome, Italy.
Vecchione A; Faculty of Medicine and Psychology, Department Clinical and Molecular Medicine, Sant'Andrea Hospital, Sapienza University of Rome, 00118, Rome, Italy.
Carriero MV; Preclinical Models of Tumor Progression Unit, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', 80131, Naples, Italy.
Ascierto PA; Unit of Melanoma, Cancer Immunotherapy and Development Therapeutics, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', 80131, Naples, Italy.
Mancini R; Department of Clinical and Molecular Medicine, Sapienza University of Rome, 00161, Rome, Italy.; Faculty of Medicine and Psychology, Department Clinical and Molecular Medicine, Sant'Andrea Hospital, Sapienza University of Rome, 00118, Rome, Italy.
Fattore L; SAFU Laboratory, Department of Research, Advanced Diagnostics and Technological Innovation, Translational Research Area, IRCCS Regina Elena National Cancer Institute, 00144, Rome, Italy. .
Ciliberto G; Scientific Directorate, IRCSS Regina Elena National Cancer Institute, 00144, Rome, Italy.
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Źródło:
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2023 Nov 27; Vol. 42 (1), pp. 317. Date of Electronic Publication: 2023 Nov 27.
Typ publikacji:
Journal Article
MeSH Terms:
Melanoma*/drug therapy
Melanoma*/genetics
Melanoma*/pathology
MicroRNAs*/metabolism
Humans ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Down-Regulation ; Gene Expression Regulation, Neoplastic ; Intermediate Filaments/metabolism ; Intermediate Filaments/pathology ; Nestin/genetics ; Nestin/metabolism ; Phenotype ; Proto-Oncogene Proteins B-raf/genetics ; Proto-Oncogene Proteins B-raf/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Emerging Targeted Therapeutic Strategies to Overcome Imatinib Resistance of Gastrointestinal Stromal Tumors.
Autorzy:
Masucci MT; Preclinical Models of Tumor Progression Unit, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', 80131 Naples, Italy.
Motti ML; Preclinical Models of Tumor Progression Unit, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', 80131 Naples, Italy.; Department of Movement Sciences and Wellbeing, University 'Parthenope', 80133 Naples, Italy.
Minopoli M; Preclinical Models of Tumor Progression Unit, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', 80131 Naples, Italy.
Di Carluccio G; Preclinical Models of Tumor Progression Unit, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', 80131 Naples, Italy.
Carriero MV; Preclinical Models of Tumor Progression Unit, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', 80131 Naples, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 Mar 23; Vol. 24 (7). Date of Electronic Publication: 2023 Mar 23.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Gastrointestinal Stromal Tumors*/drug therapy
Gastrointestinal Stromal Tumors*/genetics
Gastrointestinal Stromal Tumors*/pathology
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Gastrointestinal Neoplasms*/drug therapy
Gastrointestinal Neoplasms*/genetics
Gastrointestinal Neoplasms*/pathology
Humans ; Imatinib Mesylate/pharmacology ; Imatinib Mesylate/therapeutic use ; Proto-Oncogene Proteins c-kit/genetics ; Receptor, Platelet-Derived Growth Factor alpha/genetics ; Mutation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Crosstalk between Macrophages and Myxoid Liposarcoma Cells Increases Spreading and Invasiveness of Tumor Cells.
Autorzy:
Minopoli M; Neoplastic Progression Unit, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', 80131 Naples, Italy.
Sarno S; Neoplastic Progression Unit, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', 80131 Naples, Italy.
Cannella L; Medical Oncology Unit, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', 80131 Naples, Italy.
Tafuto S; Medical Oncology Unit, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', 80131 Naples, Italy.
Scognamiglio G; Pathology Unit, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', 80131 Naples, Italy.
Gallo M; Musculoskeletal Surgery Unit, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', 80131 Naples, Italy.
Fazioli F; Musculoskeletal Surgery Unit, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', 80131 Naples, Italy.
Azzaro R; Transfusion Medicine Unit, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', 80131 Naples, Italy.
Apice G; Medical Oncology Unit, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', 80131 Naples, Italy.
De Angelis B; Department of Onco-Haematology and Cell and Gene Therapy Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
Tamborini E; Department of Pathology, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.
Garofalo C; Advanced Translational Research Laboratory, Veneto Institute of Oncology IOV-IRCCS, 35128 Padua, Italy.
Pignochino Y; Department of Clinical and Biological Sciences, University of Turin, 10124 Torino, Italy.; Division of Medical Oncology, Candiolo Cancer Institute, FPO-IRCCS, 10060 Candiolo, Italy.
Mercatali L; Osteoncology and Rare Tumors Center, Istituto Romagnolo per lo Studio dei Tumori 'Dino Amadori' (IRST) IRCCS, 47010 Meldola, Italy.
Ibrahim T; Osteoncology and Rare Tumors Center, Istituto Romagnolo per lo Studio dei Tumori 'Dino Amadori' (IRST) IRCCS, 47010 Meldola, Italy.
Falcioni R; Department of Research, Diagnosis and Innovative Technology, IRCCS Regina Elena National Cancer Institute, 00128 Rome, Italy.
Valenti B; Oncogenetics and Functional Oncogenomics, Centro di Riferimento Oncologico di Aviano (CRO Aviano) IRCCS, National Cancer Institute, 33081 Aviano, Italy.
Maestro R; Oncogenetics and Functional Oncogenomics, Centro di Riferimento Oncologico di Aviano (CRO Aviano) IRCCS, National Cancer Institute, 33081 Aviano, Italy.
Scotlandi K; Laboratory of Experimental Oncology, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.
De Chiara A; Pathology Unit, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', 80131 Naples, Italy.
Carriero MV; Neoplastic Progression Unit, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', 80131 Naples, Italy.
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Źródło:
Cancers [Cancers (Basel)] 2021 Jun 30; Vol. 13 (13). Date of Electronic Publication: 2021 Jun 30.
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
MicroRNAs as Key Players in Melanoma Cell Resistance to MAPK and Immune Checkpoint Inhibitors.
Autorzy:
Motti ML; Department of Motor and Wellness Sciences, University 'Parthenope', 80133 Naples, Italy.
Minopoli M; Neoplastic Progression Unit, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', 80131 Naples, Italy.
Di Carluccio G; Neoplastic Progression Unit, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', 80131 Naples, Italy.
Ascierto PA; Melanoma, Cancer Immunotherapy and Development Therapeutics Unit, Istituto Nazionale Tumori-IRCCS Fondazione 'G. Pascale', 80131 Naples, Italy.
Carriero MV; Neoplastic Progression Unit, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', 80131 Naples, Italy.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Jun 26; Vol. 21 (12). Date of Electronic Publication: 2020 Jun 26.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Drug Resistance, Neoplasm*
Immune Checkpoint Inhibitors/*therapeutic use
Melanoma/*genetics
MicroRNAs/*genetics
Mitogen-Activated Protein Kinases/*chemistry
Protein Kinase Inhibitors/*therapeutic use
Animals ; Humans ; Melanoma/drug therapy ; Melanoma/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Inhibiting Monocyte Recruitment to Prevent the Pro-Tumoral Activity of Tumor-Associated Macrophages in Chondrosarcoma.
Autorzy:
Minopoli M; Neoplastic Progression Unit, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', Naples 80131, Italy.
Sarno S; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli', 80138 Naples, Italy.
Di Carluccio G; Neoplastic Progression Unit, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', Naples 80131, Italy.
Azzaro R; Transfusion Medicine Unit, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', 80131 Naples, Italy.
Costantini S; Experimental Pharmacology Unit, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', 80131 Naples, Italy.
Fazioli F; Division of Musculoskeletal Surgery, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', 80131 Naples, Italy.
Gallo M; Division of Musculoskeletal Surgery, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', 80131 Naples, Italy.
Apice G; Division of Medical Oncology, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', 80131 Naples, Italy.
Cannella L; Division of Medical Oncology, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', 80131 Naples, Italy.
Rea D; Animal Facility, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', 80131 Naples, Italy.
Stoppelli MP; Institute of Genetics and Biophysics, National Research Council, 80131 Naples, Italy.
Boraschi D; Institute of Biochemistry and Cell Biology, National Research Council, 80131 Naples, Italy.
Budillon A; Experimental Pharmacology Unit, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', 80131 Naples, Italy.
Scotlandi K; Laboratory of Experimental Oncology, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.
De Chiara A; Pathology Unit, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', 80131 Naples, Italy.
Carriero MV; Neoplastic Progression Unit, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', Naples 80131, Italy.
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Źródło:
Cells [Cells] 2020 Apr 24; Vol. 9 (4). Date of Electronic Publication: 2020 Apr 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Chondrosarcoma/*pathology
Monocytes/*pathology
Tumor-Associated Macrophages/*pathology
Adult ; Aged ; Animals ; Antigens, CD/metabolism ; Collagen/pharmacology ; Female ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; Immunophenotyping ; Male ; Mice, Nude ; Microvessels/pathology ; Middle Aged ; Monocytes/drug effects ; Phenotype ; Spheroids, Cellular/drug effects ; Spheroids, Cellular/pathology ; THP-1 Cells ; Time Factors ; Tumor-Associated Macrophages/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Targeting the Formyl Peptide Receptor type 1 to prevent the adhesion of ovarian cancer cells onto mesothelium and subsequent invasion.
Autorzy:
Minopoli M; Neoplastic Progression Unit, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', Via M.Semmola, 80131, Naples, Italy.
Botti G; University of Campania 'Luigi Vanvitelli', Naples, Italy.
Gigantino V; Pathology Unit, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', Naples, Italy.
Ragone C; Neoplastic Progression Unit, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', Via M.Semmola, 80131, Naples, Italy.
Sarno S; Neoplastic Progression Unit, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', Via M.Semmola, 80131, Naples, Italy.; Pathology Unit, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', Naples, Italy.
Motti ML; University 'Parthenope', Naples, Italy.
Scognamiglio G; Pathology Unit, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', Naples, Italy.
Greggi S; Gynecologic Oncology, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', Naples, Italy.
Scaffa C; Gynecologic Oncology, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', Naples, Italy.
Roca MS; Experimental Pharmacology Unit, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', Naples, Italy.
Stoppelli MP; Institute of Genetics and Biophysics, National Research Council, Naples, Italy.
Ciliberto G; Istituto Nazionale Tumori IRCCS 'Regina Elena', Rome, Italy.
Losito NS; Pathology Unit, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', Naples, Italy.
Carriero MV; Neoplastic Progression Unit, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', Via M.Semmola, 80131, Naples, Italy. m.carriero@istitutotumori.na.it.
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Źródło:
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2019 Nov 08; Vol. 38 (1), pp. 459. Date of Electronic Publication: 2019 Nov 08.
Typ publikacji:
Journal Article
MeSH Terms:
Cell Adhesion/*drug effects
Cell Movement/*drug effects
Ovarian Neoplasms/*metabolism
Receptors, Formyl Peptide/*antagonists & inhibitors
Receptors, Formyl Peptide/*metabolism
Adult ; Aged ; Antineoplastic Agents/pharmacology ; Biomarkers, Tumor ; Cell Line, Tumor ; Extracellular Matrix Proteins/metabolism ; Female ; Gene Expression ; Humans ; Middle Aged ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/pathology ; Receptors, Formyl Peptide/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Structure-function relationship of an Urokinase Receptor-derived peptide which inhibits the Formyl Peptide Receptor type 1 activity.
Autorzy:
Minopoli M; Neoplastic Progression Unit, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', Naples, Italy.
Polo A; Experimental Pharmacology Unit, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', Napoli, Italy.
Ragone C; Neoplastic Progression Unit, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', Naples, Italy.
Ingangi V; Immunologia e Diagnostica molecolare Istituto Oncologico Veneto, Padova, Italy.
Ciliberto G; Scientific Directorate, Istituto Nazionale Tumori 'Regina Elena', IRCCS, Roma, Italy.
Pessi A; Peptipharma, Roma, Italy.
Sarno S; Neoplastic Progression Unit, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', Naples, Italy.
Budillon A; Experimental Pharmacology Unit, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', Napoli, Italy.
Costantini S; Experimental Pharmacology Unit, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', Napoli, Italy. .
Carriero MV; Neoplastic Progression Unit, Istituto Nazionale Tumori IRCCS 'Fondazione G. Pascale', Naples, Italy. m.carriero@istitutotumori.na.it.
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Źródło:
Scientific reports [Sci Rep] 2019 Aug 21; Vol. 9 (1), pp. 12169. Date of Electronic Publication: 2019 Aug 21.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Peptides/*metabolism
Receptors, Formyl Peptide/*metabolism
Receptors, Urokinase Plasminogen Activator/*chemistry
Amino Acid Sequence ; Animals ; Binding Sites ; Cell Line, Tumor ; Cell Movement/drug effects ; HEK293 Cells ; Humans ; Molecular Dynamics Simulation ; Peptides/chemistry ; Peptides/pharmacology ; Protein Binding ; Protein Interaction Maps ; Protein Structure, Tertiary ; Rats ; Receptors, Formyl Peptide/chemistry ; Receptors, Formyl Peptide/genetics ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Large oncosomes overexpressing integrin alpha-V promote prostate cancer adhesion and invasion via AKT activation.
Autorzy:
Ciardiello C; Experimental Pharmacology Unit, Istituto Nazionale Tumori - IRCCS- Fondazione G. Pascale, Via M. Semmola, 80131, Naples, Italy. .
Leone A; Experimental Pharmacology Unit, Istituto Nazionale Tumori - IRCCS- Fondazione G. Pascale, Via M. Semmola, 80131, Naples, Italy.
Lanuti P; Centre on Aging Sciences and Translational Medicine (Ce.S.I.-Me.T.), University 'G.d'Annunzio', Chieti-Pescara, Italy.; Department of Medicine and Aging Sciences, University 'G. d'Annunzio', Chieti-Pescara, Italy.
Roca MS; Experimental Pharmacology Unit, Istituto Nazionale Tumori - IRCCS- Fondazione G. Pascale, Via M. Semmola, 80131, Naples, Italy.
Moccia T; Experimental Pharmacology Unit, Istituto Nazionale Tumori - IRCCS- Fondazione G. Pascale, Via M. Semmola, 80131, Naples, Italy.
Minciacchi VR; Georg-Speyer-Haus Institute for Tumor biology and Experimental Therapy, Frankfurt, Germany.
Minopoli M; Neoplastic Progression Unit, Istituto Nazionale Tumori - IRCCS- Fondazione G. Pascale, Naples, Italy.
Gigantino V; Pathology Unit, Istituto Nazionale Tumori - IRCCS- Fondazione G. Pascale, Naples, Italy.
De Cecio R; Pathology Unit, Istituto Nazionale Tumori - IRCCS- Fondazione G. Pascale, Naples, Italy.
Rippa M; Institute of Applied Sciences and Intelligent Systems 'E. Caianiello' of CNR, Pozzuoli, Italy.
Petti L; Institute of Applied Sciences and Intelligent Systems 'E. Caianiello' of CNR, Pozzuoli, Italy.
Capone F; Experimental Pharmacology Unit, Istituto Nazionale Tumori - IRCCS- Fondazione G. Pascale, Via M. Semmola, 80131, Naples, Italy.
Vitagliano C; Experimental Pharmacology Unit, Istituto Nazionale Tumori - IRCCS- Fondazione G. Pascale, Via M. Semmola, 80131, Naples, Italy.
Milone MR; Experimental Pharmacology Unit, Istituto Nazionale Tumori - IRCCS- Fondazione G. Pascale, Via M. Semmola, 80131, Naples, Italy.
Pucci B; Experimental Pharmacology Unit, Istituto Nazionale Tumori - IRCCS- Fondazione G. Pascale, Via M. Semmola, 80131, Naples, Italy.
Lombardi R; Experimental Pharmacology Unit, Istituto Nazionale Tumori - IRCCS- Fondazione G. Pascale, Via M. Semmola, 80131, Naples, Italy.
Iannelli F; Experimental Pharmacology Unit, Istituto Nazionale Tumori - IRCCS- Fondazione G. Pascale, Via M. Semmola, 80131, Naples, Italy.
Di Gennaro E; Experimental Pharmacology Unit, Istituto Nazionale Tumori - IRCCS- Fondazione G. Pascale, Via M. Semmola, 80131, Naples, Italy.
Bruzzese F; Experimental Pharmacology Unit, Istituto Nazionale Tumori - IRCCS- Fondazione G. Pascale, Via M. Semmola, 80131, Naples, Italy.
Marchisio M; Centre on Aging Sciences and Translational Medicine (Ce.S.I.-Me.T.), University 'G.d'Annunzio', Chieti-Pescara, Italy.; Department of Medicine and Aging Sciences, University 'G. d'Annunzio', Chieti-Pescara, Italy.
Carriero MV; Neoplastic Progression Unit, Istituto Nazionale Tumori - IRCCS- Fondazione G. Pascale, Naples, Italy.
Di Vizio D; Departments of Surgery, Pathology & Lab Medicine, and Biochemical Science, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Budillon A; Experimental Pharmacology Unit, Istituto Nazionale Tumori - IRCCS- Fondazione G. Pascale, Via M. Semmola, 80131, Naples, Italy. .
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Źródło:
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2019 Jul 18; Vol. 38 (1), pp. 317. Date of Electronic Publication: 2019 Jul 18.
Typ publikacji:
Journal Article
MeSH Terms:
Extracellular Vesicles/*pathology
Integrin alphaV/*metabolism
Prostatic Neoplasms/*pathology
Proto-Oncogene Proteins c-akt/*metabolism
Animals ; Cell Adhesion ; Cell Line, Tumor ; Epithelial-Mesenchymal Transition ; Extracellular Vesicles/metabolism ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Mice ; Mice, Nude ; Neoplasm Grading ; Neoplasm Invasiveness ; Neoplasm Transplantation ; Prostatic Neoplasms/metabolism ; Proteomics/methods ; Up-Regulation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Neutrophil Extracellular Traps as an Adhesion Substrate for Different Tumor Cells Expressing RGD-Binding Integrins.
Autorzy:
Monti M; Dipartimento di Medicina Clinica e Chirurgia, Università degli Studi di Napoli 'Federico II', Via S. Pansini 5, 80131 Naples, Italy. .
De Rosa V; Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche, 80145 Naples, Italy. .
Iommelli F; Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche, 80145 Naples, Italy. .
Carriero MV; Dipartimento di Oncologia Sperimentale, IRCCS Istituto Nazionale Tumori 'Fondazione G. Pascale', 80145 Naples, Italy. m.carriero@istitutotumori.na.it.
Terlizzi C; Dipartimento di Scienze Biomediche Avanzate, Università degli Studi di Napoli 'Federico II', Via S. Pansini 5, 80145 Naples, Italy. .
Camerlingo R; Dipartimento di Oncologia Sperimentale, IRCCS Istituto Nazionale Tumori 'Fondazione G. Pascale', 80145 Naples, Italy. .
Belli S; Istituto di Genetica e Biofisica, Consiglio Nazionale delle Ricerche, 80131 Naples, Italy. .
Fonti R; Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche, 80145 Naples, Italy. .
Di Minno G; Dipartimento di Medicina Clinica e Chirurgia, Università degli Studi di Napoli 'Federico II', Via S. Pansini 5, 80131 Naples, Italy. .
Del Vecchio S; Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche, 80145 Naples, Italy. .; Dipartimento di Scienze Biomediche Avanzate, Università degli Studi di Napoli 'Federico II', Via S. Pansini 5, 80145 Naples, Italy. .
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2018 Aug 09; Vol. 19 (8). Date of Electronic Publication: 2018 Aug 09.
Typ publikacji:
Journal Article
MeSH Terms:
Cell Adhesion/*genetics
Integrin alpha Chains/*genetics
Integrin beta Chains/*genetics
Protein Transport/*genetics
Cell Membrane ; Extracellular Traps ; Fibronectins/genetics ; Flow Cytometry ; Humans ; Neutrophils/cytology ; Neutrophils/metabolism ; PC-3 Cells ; Peptides/genetics ; Protein Binding
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Targeting the cross-talk between Urokinase receptor and Formyl peptide receptor type 1 to prevent invasion and trans-endothelial migration of melanoma cells.
Autorzy:
Ragone C; IRCCS Istituto Nazionale Tumori 'Fondazione G. Pascale', Naples, Italy.; University of Campania 'Luigi Vanvitelli', Naples, Italy.
Minopoli M; IRCCS Istituto Nazionale Tumori 'Fondazione G. Pascale', Naples, Italy.; University of Campania 'Luigi Vanvitelli', Naples, Italy.
Ingangi V; IRCCS Istituto Nazionale Tumori 'Fondazione G. Pascale', Naples, Italy.; University of Campania 'Luigi Vanvitelli', Naples, Italy.
Botti G; IRCCS Istituto Nazionale Tumori 'Fondazione G. Pascale', Naples, Italy.; University of Campania 'Luigi Vanvitelli', Naples, Italy.
Fratangelo F; IRCCS Istituto Nazionale Tumori 'Fondazione G. Pascale', Naples, Italy.
Pessi A; Peptipharma, Viale Città D'Europa 679, 00144, Rome, Italy.
Stoppelli MP; Institute of Genetics and Biophysics, National Research Council, Naples, Italy.
Ascierto PA; IRCCS Istituto Nazionale Tumori 'Fondazione G. Pascale', Naples, Italy.
Ciliberto G; IRCCS Istituto Nazionale Tumori Regina Elena, Rome, Italy.
Motti ML; IRCCS Istituto Nazionale Tumori 'Fondazione G. Pascale', Naples, Italy. .; University 'Parthenope', Via Acton 38, 80133, Naples, Italy. .
Carriero MV; IRCCS Istituto Nazionale Tumori 'Fondazione G. Pascale', Naples, Italy.
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Źródło:
Journal of experimental & clinical cancer research : CR [J Exp Clin Cancer Res] 2017 Dec 08; Vol. 36 (1), pp. 180. Date of Electronic Publication: 2017 Dec 08.
Typ publikacji:
Journal Article
MeSH Terms:
Melanoma/*metabolism
Receptors, Formyl Peptide/*metabolism
Urokinase-Type Plasminogen Activator/*metabolism
Cell Line, Tumor ; Cell Movement/physiology ; Cell Proliferation/physiology ; Humans ; Melanoma/genetics ; Melanoma/pathology ; Receptors, Formyl Peptide/genetics ; Transfection ; Urokinase-Type Plasminogen Activator/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Integrin-dependent cell adhesion to neutrophil extracellular traps through engagement of fibronectin in neutrophil-like cells.
Autorzy:
Monti M; Dipartimento di Medicina Clinica e Chirurgia, Università degli Studi di Napoli 'Federico II', Naples, Italy.
Iommelli F; Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche, Naples, Italy.
De Rosa V; Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche, Naples, Italy.
Carriero MV; Dipartimento di Oncologia Sperimentale, IRCCS Istituto Nazionale Tumori 'Fondazione G. Pascale', Naples, Italy.
Miceli R; Dipartimento di Oncologia Sperimentale, IRCCS Istituto Nazionale Tumori 'Fondazione G. Pascale', Naples, Italy.
Camerlingo R; Dipartimento di Oncologia Sperimentale, IRCCS Istituto Nazionale Tumori 'Fondazione G. Pascale', Naples, Italy.
Di Minno G; Dipartimento di Medicina Clinica e Chirurgia, Università degli Studi di Napoli 'Federico II', Naples, Italy.
Del Vecchio S; Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche, Naples, Italy.; Dipartimento di Scienze Biomediche Avanzate, Università degli Studi di Napoli 'Federico II', Naples, Italy.
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Źródło:
PloS one [PLoS One] 2017 Feb 06; Vol. 12 (2), pp. e0171362. Date of Electronic Publication: 2017 Feb 06 (Print Publication: 2017).
Typ publikacji:
Journal Article
MeSH Terms:
Cell Adhesion*
Extracellular Traps/*metabolism
Integrins/*metabolism
Neutrophils/*physiology
Biomarkers ; Fibronectins/metabolism ; Histones/metabolism ; Humans ; Peroxidase/metabolism ; Protein Binding ; Protein Transport
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A Macroscopic Mathematical Model for Cell Migration Assays Using a Real-Time Cell Analysis.
Autorzy:
Di Costanzo E; Istituto per le Applicazioni del Calcolo 'M. Picone', Consiglio Nazionale delle Ricerche, Naples, Italy.
Ingangi V; Neoplastic Progression Unit, Department of Experimental Oncology, IRCCS Istituto Nazionale Tumori 'Fondazione G. Pascale', Naples, Italy.; SUN Second University of Naples, Naples, Italy.
Angelini C; Istituto per le Applicazioni del Calcolo 'M. Picone', Consiglio Nazionale delle Ricerche, Naples, Italy.
Carfora MF; Istituto per le Applicazioni del Calcolo 'M. Picone', Consiglio Nazionale delle Ricerche, Naples, Italy.
Carriero MV; Neoplastic Progression Unit, Department of Experimental Oncology, IRCCS Istituto Nazionale Tumori 'Fondazione G. Pascale', Naples, Italy.
Natalini R; Istituto per le Applicazioni del Calcolo 'M. Picone', Consiglio Nazionale delle Ricerche, Naples, Italy.
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Źródło:
PloS one [PLoS One] 2016 Sep 28; Vol. 11 (9), pp. e0162553. Date of Electronic Publication: 2016 Sep 28 (Print Publication: 2016).
Typ publikacji:
Journal Article
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Cyclization of the urokinase receptor-derived ser-arg-ser-arg-tyr Peptide generates a potent inhibitor of trans-endothelial migration of monocytes.
Autorzy:
Yousif AM; Department of Pharmacy, University Federico II, Naples, Italy.
Minopoli M; Neoplastic Progression Unit, Department of Experimental Oncology, IRCCS Istituto Nazionale Tumori 'Fondazione G. Pascale', Naples, Italy.
Bifulco K; Neoplastic Progression Unit, Department of Experimental Oncology, IRCCS Istituto Nazionale Tumori 'Fondazione G. Pascale', Naples, Italy.
Ingangi V; Neoplastic Progression Unit, Department of Experimental Oncology, IRCCS Istituto Nazionale Tumori 'Fondazione G. Pascale', Naples, Italy; SUN Second University of Naples, Italy.
Di Carluccio G; Neoplastic Progression Unit, Department of Experimental Oncology, IRCCS Istituto Nazionale Tumori 'Fondazione G. Pascale', Naples, Italy.
Merlino F; Department of Pharmacy, University Federico II, Naples, Italy.
Motti ML; University 'Parthenope', Naples, Italy.
Grieco P; Department of Pharmacy, University Federico II, Naples, Italy; CIRPEB: Centro Interuniversitario di Ricerca sui Peptidi Bioattivi University of Naples 'Federico II', DFM-Scarl, Institute of Biostructures and Bioimaging-CNR, 80134, Naples, Italy.
Carriero MV; Neoplastic Progression Unit, Department of Experimental Oncology, IRCCS Istituto Nazionale Tumori 'Fondazione G. Pascale', Naples, Italy.
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Źródło:
PloS one [PLoS One] 2015 May 04; Vol. 10 (5), pp. e0126172. Date of Electronic Publication: 2015 May 04 (Print Publication: 2015).
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Monocytes/*drug effects
Monocytes/*physiology
Peptides/*metabolism
Peptides/*pharmacology
Receptors, Urokinase Plasminogen Activator/*chemistry
Receptors, Urokinase Plasminogen Activator/*metabolism
Transendothelial and Transepithelial Migration/*drug effects
Amino Acid Sequence ; Animals ; Cell Line ; Cell Line, Tumor ; Chromatography, High Pressure Liquid ; Cyclization ; Macrophages/drug effects ; Macrophages/physiology ; Peptides/chemistry ; Protein Binding ; Rats
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
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