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Tytuł :
FAM20C Overview: Classic and Novel Targets, Pathogenic Variants and Raine Syndrome Phenotypes.
Autorzy :
Palma-Lara I; Laboratorio de Morfología Celular y Molecular, Sección de Estudios de Posgrado e Investigación, Instituto Politécnico Nacional, Escuela Superior de Medicina, Ciudad de México 11340, Mexico.
Pérez-Ramírez M; Laboratorio de Morfología Celular y Molecular, Sección de Estudios de Posgrado e Investigación, Instituto Politécnico Nacional, Escuela Superior de Medicina, Ciudad de México 11340, Mexico.
García Alonso-Themann P; Instituto Nacional de Perinatología, Seguimiento Pediátrico, Ciudad de México 11000, Mexico.
Espinosa-García AM; Laboratorio de Farmacología Clínica, Hospital General de México, Ciudad de México 06720, Mexico.
Godinez-Aguilar R; División de Investigación, Hospital Juárez de México, Ciudad de México 07760, Mexico.
Bonilla-Delgado J; División de Investigación, Hospital Juárez de México, Ciudad de México 07760, Mexico.
López-Ornelas A; División de Investigación, Hospital Juárez de México, Ciudad de México 07760, Mexico.
Victoria-Acosta G; División de Investigación, Hospital Juárez de México, Ciudad de México 07760, Mexico.
Olguín-García MG; Centro Dermatológico 'Dr. Ladislao de la Pascua' SSPCDMX, Departamento de Educación e Investigación, Ciudad de México 06780, Mexico.
Moreno J; División de Investigación, Hospital Juárez de México, Ciudad de México 07760, Mexico.
Palacios-Reyes C; División de Investigación, Hospital Juárez de México, Ciudad de México 07760, Mexico.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 27; Vol. 22 (15). Date of Electronic Publication: 2021 Jul 27.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Abnormalities, Multiple*/genetics
Abnormalities, Multiple*/metabolism
Abnormalities, Multiple*/mortality
Abnormalities, Multiple*/pathology
Casein Kinase I*/genetics
Casein Kinase I*/metabolism
Cleft Palate*/genetics
Cleft Palate*/metabolism
Cleft Palate*/mortality
Cleft Palate*/pathology
Exophthalmos*/genetics
Exophthalmos*/metabolism
Exophthalmos*/mortality
Exophthalmos*/pathology
Extracellular Matrix Proteins*/genetics
Extracellular Matrix Proteins*/metabolism
Genetic Variation*
Microcephaly*/genetics
Microcephaly*/metabolism
Microcephaly*/mortality
Microcephaly*/pathology
Osteosclerosis*/genetics
Osteosclerosis*/metabolism
Osteosclerosis*/mortality
Osteosclerosis*/pathology
Phenotype*
Humans
SCR Disease Name :
Raine syndrome
Czasopismo naukowe
Tytuł :
Protein Kinase CK2 Regulates B Cell Development and Differentiation.
Autorzy :
Wei H; Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294; and.
Yang W; Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294; and.
Hong H; Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294; and.
Yan Z; Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294; and.; Gladstone Institute of Neurological Disease, San Francisco, CA 94158.
Qin H; Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294; and .
Benveniste EN; Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294; and.
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Źródło :
Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2021 Aug 01; Vol. 207 (3), pp. 799-808. Date of Electronic Publication: 2021 Jul 23.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
B-Lymphocytes/*immunology
Casein Kinase II/*metabolism
Precursor Cells, B-Lymphoid/*immunology
Animals ; Antigens, CD19/metabolism ; Casein Kinase II/genetics ; Cell Differentiation ; Cells, Cultured ; Integrases/metabolism ; Lymphocyte Activation ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; NF-kappa B/metabolism ; Receptors, Antigen, B-Cell/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Reversible modulation of circadian time with chronophotopharmacology.
Autorzy :
Kolarski D; Centre for Systems Chemistry, Stratingh Institute for Chemistry, University of Groningen, Groningen, The Netherlands.
Miró-Vinyals C; Centre for Systems Chemistry, Stratingh Institute for Chemistry, University of Groningen, Groningen, The Netherlands.
Sugiyama A; Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Chikusa, Nagoya, Japan.
Srivastava A; Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Chikusa, Nagoya, Japan.
Ono D; Department of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University, Chikusa, Nagoya, Japan.
Nagai Y; Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Chikusa, Nagoya, Japan.
Iida M; Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Chikusa, Nagoya, Japan.; Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa, Nagoya, Japan.
Itami K; Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Chikusa, Nagoya, Japan.; Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa, Nagoya, Japan.
Tama F; Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Chikusa, Nagoya, Japan.; Department of Physics, Graduate School of Science, Nagoya University, Chikusa, Nagoya, Japan.; Computational Structural Biology Unit, RIKEN-Center for Computational Science, Kobe, Hyogo, Japan.
Szymanski W; Centre for Systems Chemistry, Stratingh Institute for Chemistry, University of Groningen, Groningen, The Netherlands. .; Department of Radiology, Medical Imaging Center, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. .
Hirota T; Institute of Transformative Bio-Molecules (WPI-ITbM), Nagoya University, Chikusa, Nagoya, Japan. .; Division of Biological Science, Graduate School of Science, Nagoya University, Chikusa, Nagoya, Japan. .
Feringa BL; Centre for Systems Chemistry, Stratingh Institute for Chemistry, University of Groningen, Groningen, The Netherlands. .
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Źródło :
Nature communications [Nat Commun] 2021 May 26; Vol. 12 (1), pp. 3164. Date of Electronic Publication: 2021 May 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Drug Chronotherapy*
Casein Kinase Ialpha/*antagonists & inhibitors
Casein Kinase Idelta/*antagonists & inhibitors
Circadian Rhythm/*drug effects
Protein Kinase Inhibitors/*pharmacology
Animals ; Casein Kinase Ialpha/metabolism ; Casein Kinase Ialpha/ultrastructure ; Casein Kinase Idelta/metabolism ; Cell Line, Tumor ; Chronobiology Disorders/drug therapy ; Circadian Clocks/radiation effects ; Drug Evaluation, Preclinical ; Enzyme Assays ; Humans ; Light ; Mice ; Mice, Transgenic ; Molecular Docking Simulation ; Photoperiod ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/radiation effects ; Suprachiasmatic Nucleus/drug effects ; Suprachiasmatic Nucleus/metabolism ; Tissue Culture Techniques
Czasopismo naukowe
Tytuł :
Targeting Protein Kinases in Blood Cancer: Focusing on CK1α and CK2.
Autorzy :
Spinello Z; Department of Medicine, Hematology Section, University of Padova, Via N. Giustiniani 2, 35128 Padova, Italy.; Veneto Institute of Molecular Medicine, Via G. Orus 2, 35129 Padova, Italy.
Fregnani A; Department of Medicine, Hematology Section, University of Padova, Via N. Giustiniani 2, 35128 Padova, Italy.; Veneto Institute of Molecular Medicine, Via G. Orus 2, 35129 Padova, Italy.
Quotti Tubi L; Department of Medicine, Hematology Section, University of Padova, Via N. Giustiniani 2, 35128 Padova, Italy.; Veneto Institute of Molecular Medicine, Via G. Orus 2, 35129 Padova, Italy.
Trentin L; Department of Medicine, Hematology Section, University of Padova, Via N. Giustiniani 2, 35128 Padova, Italy.; Veneto Institute of Molecular Medicine, Via G. Orus 2, 35129 Padova, Italy.
Piazza F; Department of Medicine, Hematology Section, University of Padova, Via N. Giustiniani 2, 35128 Padova, Italy.; Veneto Institute of Molecular Medicine, Via G. Orus 2, 35129 Padova, Italy.
Manni S; Department of Medicine, Hematology Section, University of Padova, Via N. Giustiniani 2, 35128 Padova, Italy.; Veneto Institute of Molecular Medicine, Via G. Orus 2, 35129 Padova, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 02; Vol. 22 (7). Date of Electronic Publication: 2021 Apr 02.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Casein Kinase II/*metabolism
Casein Kinase Ialpha/*metabolism
Hematologic Neoplasms/*metabolism
Animals ; Casein Kinase II/antagonists & inhibitors ; Casein Kinase Ialpha/antagonists & inhibitors ; Hematologic Neoplasms/drug therapy ; Humans ; Molecular Targeted Therapy ; Stress, Physiological
Czasopismo naukowe
Tytuł :
CK1δ-Derived Peptides as Novel Tools Inhibiting the Interactions between CK1δ and APP695 to Modulate the Pathogenic Metabolism of APP.
Autorzy :
Roth A; Surgery Centre, Department of General and Visceral Surgery, Ulm University Hospital, Albert-Einstein-Allee 23, 89081 Ulm, Germany.
Gärtner F; Surgery Centre, Department of General and Visceral Surgery, Ulm University Hospital, Albert-Einstein-Allee 23, 89081 Ulm, Germany.
Mayer K; Surgery Centre, Department of General and Visceral Surgery, Ulm University Hospital, Albert-Einstein-Allee 23, 89081 Ulm, Germany.
Beyrle J; Surgery Centre, Department of General and Visceral Surgery, Ulm University Hospital, Albert-Einstein-Allee 23, 89081 Ulm, Germany.
König I; Surgery Centre, Department of General and Visceral Surgery, Ulm University Hospital, Albert-Einstein-Allee 23, 89081 Ulm, Germany.
Knippschild U; Surgery Centre, Department of General and Visceral Surgery, Ulm University Hospital, Albert-Einstein-Allee 23, 89081 Ulm, Germany.
Bischof J; Surgery Centre, Department of General and Visceral Surgery, Ulm University Hospital, Albert-Einstein-Allee 23, 89081 Ulm, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jun 15; Vol. 22 (12). Date of Electronic Publication: 2021 Jun 15.
Typ publikacji :
Journal Article
MeSH Terms :
Amyloid beta-Protein Precursor/*metabolism
Casein Kinase Idelta/*metabolism
Peptides/*metabolism
Amyloid beta-Protein Precursor/chemistry ; Casein Kinase Idelta/chemistry ; Cell Death ; Cell Survival ; Humans ; Molecular Docking Simulation ; Neurons/metabolism ; Phosphorylation ; Plaque, Amyloid/metabolism ; Plaque, Amyloid/pathology ; Protein Binding
Czasopismo naukowe
Tytuł :
Genome-wide identification, evolutionary estimation and functional characterization of two cotton CKI gene types.
Autorzy :
Li Y; National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan , 430070, Hubei, China.
Li Y; National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan , 430070, Hubei, China.; College of Life Sciences, State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, South China Agricultural University, Guangzhou , 510642, Guangdong, China.
Chen Y; National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan , 430070, Hubei, China.
Wang M; National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan , 430070, Hubei, China.
Yang J; Institute of Economic Crops, Xinjiang Academy of Agricultural Sciences, Xinjiang, 830091, China.
Zhang X; National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan , 430070, Hubei, China.
Zhu L; National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan , 430070, Hubei, China.
Kong J; Institute of Economic Crops, Xinjiang Academy of Agricultural Sciences, Xinjiang, 830091, China. .
Min L; National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan , 430070, Hubei, China. .
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Źródło :
BMC plant biology [BMC Plant Biol] 2021 May 22; Vol. 21 (1), pp. 229. Date of Electronic Publication: 2021 May 22.
Typ publikacji :
Journal Article
MeSH Terms :
Evolution, Molecular*
Casein Kinase I/*genetics
Gossypium/*genetics
Plant Proteins/*genetics
Casein Kinase I/metabolism ; Genome, Plant ; Gossypium/growth & development ; Gossypium/metabolism ; Plant Proteins/metabolism
Czasopismo naukowe
Tytuł :
Protein kinase CK2: a potential therapeutic target for diverse human diseases.
Autorzy :
Borgo C; Department of Biomedical Sciences, University of Padua, Padua, Italy.
D'Amore C; Department of Biomedical Sciences, University of Padua, Padua, Italy.
Sarno S; Department of Biomedical Sciences, University of Padua, Padua, Italy.
Salvi M; Department of Biomedical Sciences, University of Padua, Padua, Italy.
Ruzzene M; Department of Biomedical Sciences, University of Padua, Padua, Italy. .; CNR Institute of Neuroscience, University of Padua, Padua, Italy. .
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Źródło :
Signal transduction and targeted therapy [Signal Transduct Target Ther] 2021 May 17; Vol. 6 (1), pp. 183. Date of Electronic Publication: 2021 May 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
COVID-19*/drug therapy
COVID-19*/enzymology
COVID-19*/genetics
Cardiovascular Diseases*/drug therapy
Cardiovascular Diseases*/enzymology
Cardiovascular Diseases*/genetics
Casein Kinase II*/antagonists & inhibitors
Casein Kinase II*/genetics
Casein Kinase II*/metabolism
Cystic Fibrosis*/drug therapy
Cystic Fibrosis*/enzymology
Cystic Fibrosis*/genetics
Eye Diseases*/drug therapy
Eye Diseases*/enzymology
Eye Diseases*/genetics
Mental Disorders*/drug therapy
Mental Disorders*/enzymology
Mental Disorders*/genetics
SARS-CoV-2*
Protein Kinase Inhibitors/*therapeutic use
Humans ; Mutation ; Phosphorylation ; Signal Transduction/drug effects ; Signal Transduction/genetics
Czasopismo naukowe
Tytuł :
The multifaceted role of protein kinase CK2 in high-risk acute lymphoblastic leukemia.
Autorzy :
Zhou Y; Department of Gynecology, Wuhan University Renmin Hospital, Wuhan, Hubei, P. R. China.
Lian H; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA.
Shen N; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA.
Korm S; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA.
Kwok Ping Lam A; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA.
Layton O; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA.
Huiting LN; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA.
Li D; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA.
Miao K; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA.
Zeng A; Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA.
Landesman-Bollag E; Department of Medicine, Section of Hematology and Medical Oncology, Boston University School of Medicine, Boston, MA, USA.
Seldin DC; Department of Medicine, Section of Hematology and Medical Oncology, Boston University School of Medicine, Boston, MA, USA.
Fu H; Department of Anatomy and Embryology, Wuhan University School of Basic Medical Sciences, Wuhan, Hubei, P. R. China.
Hong L; Department of Gynecology, Wuhan University Renmin Hospital, Wuhan, Hubei, P. R. China.
Feng H; Department of Pharmacology and Experimental Therapeutics, Department of Medicine, Section of Hematology and Medical Oncology, Boston University School of Medicine, Boston, MA, USA.
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Źródło :
Haematologica [Haematologica] 2021 May 01; Vol. 106 (5), pp. 1461-1465. Date of Electronic Publication: 2021 May 01.
Typ publikacji :
Letter; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Casein Kinase II*/genetics
Casein Kinase II*/metabolism
Precursor Cell Lymphoblastic Leukemia-Lymphoma*/genetics
Gene Expression Regulation, Leukemic ; Humans ; Ikaros Transcription Factor/genetics
Raport
Tytuł :
Development of a potent and selective chemical probe for the pleiotropic kinase CK2.
Autorzy :
Wells CI; Structural Genomics Consortium (SGC), UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC 27599, USA; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, UNC-CH, Chapel Hill, NC 27599, USA.
Drewry DH; Structural Genomics Consortium (SGC), UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC 27599, USA; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, UNC-CH, Chapel Hill, NC 27599, USA.
Pickett JE; Structural Genomics Consortium (SGC), UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC 27599, USA; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, UNC-CH, Chapel Hill, NC 27599, USA.
Tjaden A; Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe-University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany; Structural Genomics Consortium, Buchman Institute for Life Sciences, Johann Wolfgang Goethe-University, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany.
Krämer A; Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe-University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany; Structural Genomics Consortium, Buchman Institute for Life Sciences, Johann Wolfgang Goethe-University, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany.
Müller S; Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe-University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany; Structural Genomics Consortium, Buchman Institute for Life Sciences, Johann Wolfgang Goethe-University, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany.
Gyenis L; Department of Biochemistry, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario, N6A 5C1, Canada.
Menyhart D; Department of Biochemistry, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario, N6A 5C1, Canada.
Litchfield DW; Department of Biochemistry, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario, N6A 5C1, Canada; Department of Oncology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario, N6A 5C1, Canada.
Knapp S; Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe-University, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany; Structural Genomics Consortium, Buchman Institute for Life Sciences, Johann Wolfgang Goethe-University, Max-von-Laue-Str. 15, 60438 Frankfurt am Main, Germany.
Axtman AD; Structural Genomics Consortium (SGC), UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill (UNC-CH), Chapel Hill, NC 27599, USA; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, UNC-CH, Chapel Hill, NC 27599, USA. Electronic address: .
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Źródło :
Cell chemical biology [Cell Chem Biol] 2021 Apr 15; Vol. 28 (4), pp. 546-558.e10. Date of Electronic Publication: 2021 Jan 22.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Drug Development*
Casein Kinase II/*antagonists & inhibitors
Protein Kinase Inhibitors/*pharmacology
Pyrazoles/*pharmacology
Pyrimidines/*pharmacology
Casein Kinase II/metabolism ; Cell Line, Tumor ; Crystallography, X-Ray ; Dose-Response Relationship, Drug ; Humans ; Models, Molecular ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Pyrazoles/chemical synthesis ; Pyrazoles/chemistry ; Pyrimidines/chemical synthesis ; Pyrimidines/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Arabidopsis casein kinase 2 triggers stem cell exhaustion under Al toxicity and phosphate deficiency through activating the DNA damage response pathway.
Autorzy :
Wei P; Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent B-9052, Belgium.; VIB Center for Plant Systems Biology, Ghent B-9052, Belgium.
Demulder M; Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent B-9052, Belgium.; VIB Center for Plant Systems Biology, Ghent B-9052, Belgium.; Structural Biology Brussels, Vrije Universiteit Brussel, Brussel B-1050, Belgium.; VIB Center for Structural Biology, Brussel B-1050, Belgium.
David P; CEA, CNRS, BIAM, UMR7265, SAVE (Signalisation pour l'Adaptation des V�g�taux � leur Environnement), Aix Marseille Univ, F-13108, Saint-Paul lez Durance, France.
Eekhout T; Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent B-9052, Belgium.; VIB Center for Plant Systems Biology, Ghent B-9052, Belgium.
Yoshiyama KO; Graduate School of Life Sciences, Tohoku University, Sendai, Miyagi 980-8577, Japan.
Nguyen L; VIB Screening Core, VIB, Ghent B-9052, Belgium.; Expertise Centre for Bioassay Development and Screening (C-BIOS), Ghent University, Ghent 9000, Belgium.
Vercauteren I; Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent B-9052, Belgium.; VIB Center for Plant Systems Biology, Ghent B-9052, Belgium.
Eeckhout D; Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent B-9052, Belgium.; VIB Center for Plant Systems Biology, Ghent B-9052, Belgium.
Galle M; Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent B-9052, Belgium.; VIB Center for Plant Systems Biology, Ghent B-9052, Belgium.; Structural Biology Brussels, Vrije Universiteit Brussel, Brussel B-1050, Belgium.; VIB Center for Structural Biology, Brussel B-1050, Belgium.
De Jaeger G; Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent B-9052, Belgium.; VIB Center for Plant Systems Biology, Ghent B-9052, Belgium.
Larsen P; Department of Biochemistry, University of California, Riverside, CA 92521, USA.
Audenaert D; VIB Screening Core, VIB, Ghent B-9052, Belgium.; Expertise Centre for Bioassay Development and Screening (C-BIOS), Ghent University, Ghent 9000, Belgium.
Desnos T; CEA, CNRS, BIAM, UMR7265, SAVE (Signalisation pour l'Adaptation des V�g�taux � leur Environnement), Aix Marseille Univ, F-13108, Saint-Paul lez Durance, France.
Nussaume L; CEA, CNRS, BIAM, UMR7265, SAVE (Signalisation pour l'Adaptation des V�g�taux � leur Environnement), Aix Marseille Univ, F-13108, Saint-Paul lez Durance, France.
Loris R; Structural Biology Brussels, Vrije Universiteit Brussel, Brussel B-1050, Belgium.; VIB Center for Structural Biology, Brussel B-1050, Belgium.
De Veylder L; Department of Plant Biotechnology and Bioinformatics, Ghent University, Ghent B-9052, Belgium.; VIB Center for Plant Systems Biology, Ghent B-9052, Belgium.
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Źródło :
The Plant cell [Plant Cell] 2021 May 31; Vol. 33 (4), pp. 1361-1380.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aluminum/*toxicity
Arabidopsis/*cytology
Arabidopsis/*drug effects
Casein Kinase II/*metabolism
Phosphates/*metabolism
Aluminum/pharmacokinetics ; Arabidopsis/physiology ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Ataxia Telangiectasia Mutated Proteins/metabolism ; Casein Kinase II/genetics ; Intercellular Signaling Peptides and Proteins ; Phosphates/pharmacology ; Phosphorylation ; Plant Cells/drug effects ; Plant Roots/growth & development ; Plant Roots/metabolism ; Plants, Genetically Modified ; Transcription Factors/genetics ; Transcription Factors/metabolism
Czasopismo naukowe
Tytuł :
A New Chemical Probe Challenges the Broad Cancer Essentiality of CK2.
Autorzy :
Licciardello MP; Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK.
Workman P; Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, The Institute of Cancer Research, London, UK. Electronic address: .
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Źródło :
Trends in pharmacological sciences [Trends Pharmacol Sci] 2021 May; Vol. 42 (5), pp. 313-315. Date of Electronic Publication: 2021 Mar 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Comment
MeSH Terms :
Casein Kinase II*
Neoplasms*/drug therapy
Humans ; Protein Kinase Inhibitors
Czasopismo naukowe
Tytuł :
Discovery of 5-(3-Chlorophenylamino)benzo[ c ][2,6]naphthyridine Derivatives as Highly Selective CK2 Inhibitors with Potent Cancer Cell Stemness Inhibition.
Autorzy :
Wang Y; Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, Southeast University, Nanjing 211189, PR China.; Pharmaceutical Research Center and School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, PR China.
Lv Z; Pharmaceutical Research Center and School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, PR China.
Chen F; Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, Southeast University, Nanjing 211189, PR China.; Pharmaceutical Research Center and School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, PR China.
Wang X; Pharmaceutical Research Center and School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, PR China.
Gou S; Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, Southeast University, Nanjing 211189, PR China.; Pharmaceutical Research Center and School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, PR China.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Apr 22; Vol. 64 (8), pp. 5082-5098. Date of Electronic Publication: 2021 Apr 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*chemistry
Casein Kinase II/*antagonists & inhibitors
Naphthyridines/*chemistry
Protein Kinase Inhibitors/*chemistry
Animals ; Antineoplastic Agents/metabolism ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Apoptosis/drug effects ; Binding Sites ; Casein Kinase II/metabolism ; Cell Cycle Checkpoints/drug effects ; Drug Screening Assays, Antitumor ; Humans ; Mice ; Mice, Nude ; Molecular Docking Simulation ; Naphthyridines/metabolism ; Naphthyridines/pharmacology ; Naphthyridines/therapeutic use ; Neoplasms/drug therapy ; Neoplasms/pathology ; Neoplastic Stem Cells/cytology ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/metabolism ; Protein Kinase Inhibitors/metabolism ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Protein Kinases/chemistry ; Protein Kinases/metabolism ; Rats ; Rats, Sprague-Dawley ; Structure-Activity Relationship ; Wnt Signaling Pathway/drug effects
Czasopismo naukowe
Tytuł :
Developing novel classes of protein kinase CK1δ inhibitors by fusing [1,2,4]triazole with different bicyclic heteroaromatic systems.
Autorzy :
Grieco I; Dipartimento di Scienze Chimiche e Farmaceutiche, Università degli Studi di Trieste, Via Licio Giorgieri 1, 34127, Trieste, Italy.
Bissaro M; Molecular Modeling Section (MMS), Dipartimento di Scienze del Farmaco, Università degli Studi di Padova, via Marzolo 5, 35131, Padova, Italy.
Tiz DB; Dipartimento di Scienze Chimiche e Farmaceutiche, Università degli Studi di Trieste, Via Licio Giorgieri 1, 34127, Trieste, Italy.
Perez DI; Centro de Investigaciones Biologicas, CSIC, Ramiro de Maetzu 9, 28040, Madrid, Spain.
Perez C; Instituto de Quimica Medica, CSIC, Juan de la Cierva 3, 28006, Madrid, Spain.
Martinez A; Centro de Investigaciones Biologicas, CSIC, Ramiro de Maetzu 9, 28040, Madrid, Spain; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Instituto Carlos III, 28031, Madrid, Spain.
Redenti S; Dipartimento di Scienze Chimiche e Farmaceutiche, Università degli Studi di Trieste, Via Licio Giorgieri 1, 34127, Trieste, Italy.
Mariotto E; Dipartimento di Salute della Donna e del Bambino, Laboratorio di Oncoematologia, Università di Padova, 35131, Padova, Italy.
Bortolozzi R; Istituto di Ricerca Pediatrica (IRP), Corso Stati Uniti 4, 35128, Padova, Italy.
Viola G; Dipartimento di Salute della Donna e del Bambino, Laboratorio di Oncoematologia, Università di Padova, 35131, Padova, Italy; Istituto di Ricerca Pediatrica (IRP), Corso Stati Uniti 4, 35128, Padova, Italy.
Cozza G; Dipartimento di Medicina Molecolare, Università degli Studi di Padova, Via U. Bassi 58/B, 35131, Padova, Italy.
Spalluto G; Dipartimento di Scienze Chimiche e Farmaceutiche, Università degli Studi di Trieste, Via Licio Giorgieri 1, 34127, Trieste, Italy.
Moro S; Molecular Modeling Section (MMS), Dipartimento di Scienze del Farmaco, Università degli Studi di Padova, via Marzolo 5, 35131, Padova, Italy.
Federico S; Dipartimento di Scienze Chimiche e Farmaceutiche, Università degli Studi di Trieste, Via Licio Giorgieri 1, 34127, Trieste, Italy. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Apr 15; Vol. 216, pp. 113331. Date of Electronic Publication: 2021 Mar 02.
Typ publikacji :
Journal Article
MeSH Terms :
Casein Kinase Idelta/*antagonists & inhibitors
Protein Kinase Inhibitors/*chemistry
Triazoles/*chemistry
Binding Sites ; Blood-Brain Barrier/drug effects ; Blood-Brain Barrier/metabolism ; Casein Kinase Idelta/metabolism ; Cell Line ; Cell Survival/drug effects ; Drug Design ; Humans ; Kinetics ; Molecular Docking Simulation ; Protein Kinase Inhibitors/metabolism ; Protein Kinase Inhibitors/pharmacology ; Pyrimidines/chemistry ; Static Electricity ; Structure-Activity Relationship ; Thermodynamics ; Triazines/chemistry ; Triazoles/metabolism ; Triazoles/pharmacology
Czasopismo naukowe
Tytuł :
Structural basis for the design of bisubstrate inhibitors of protein kinase CK2 provided by complex structures with the substrate-competitive inhibitor heparin.
Autorzy :
Schnitzler A; Universität zu Köln, Department für Chemie, Institut für Biochemie, Zülpicher Straße 47, D-50674 Köln, Germany.
Niefind K; Universität zu Köln, Department für Chemie, Institut für Biochemie, Zülpicher Straße 47, D-50674 Köln, Germany. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Mar 15; Vol. 214, pp. 113223. Date of Electronic Publication: 2021 Jan 26.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Casein Kinase II/*antagonists & inhibitors
Heparin/*pharmacology
Protein Kinase Inhibitors/*pharmacology
Casein Kinase II/isolation & purification ; Casein Kinase II/metabolism ; Crystallography, X-Ray ; Dose-Response Relationship, Drug ; Heparin/chemistry ; Humans ; Models, Molecular ; Molecular Structure ; Protein Kinase Inhibitors/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Protein kinase CK2 inhibition as a pharmacological strategy.
Autorzy :
Borgo C; Department of Biomedical Sciences, University of Padova, Padova, Italy.
Ruzzene M; Department of Biomedical Sciences, University of Padova, Padova, Italy; CNR Neuroscience Institute, Padova, Italy. Electronic address: .
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Źródło :
Advances in protein chemistry and structural biology [Adv Protein Chem Struct Biol] 2021; Vol. 124, pp. 23-46. Date of Electronic Publication: 2021 Jan 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Casein Kinase II*/antagonists & inhibitors
Casein Kinase II*/metabolism
Drug Delivery Systems*
Neoplasm Proteins*/antagonists & inhibitors
Neoplasm Proteins*/metabolism
Neoplasms*/drug therapy
Neoplasms*/enzymology
Protein Kinase Inhibitors/*therapeutic use
Humans
Czasopismo naukowe
Tytuł :
The catalytic subunit of Plasmodium falciparum casein kinase 2 is essential for gametocytogenesis.
Autorzy :
Hitz E; Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, 4051, Basel, Switzerland.; University of Basel, 4001, Basel, Switzerland.
Grüninger O; Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, 4051, Basel, Switzerland.; University of Basel, 4001, Basel, Switzerland.
Passecker A; Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, 4051, Basel, Switzerland.; University of Basel, 4001, Basel, Switzerland.
Wyss M; Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, 4051, Basel, Switzerland.; University of Basel, 4001, Basel, Switzerland.
Scheurer C; Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, 4051, Basel, Switzerland.; University of Basel, 4001, Basel, Switzerland.
Wittlin S; Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, 4051, Basel, Switzerland.; University of Basel, 4001, Basel, Switzerland.
Beck HP; Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, 4051, Basel, Switzerland.; University of Basel, 4001, Basel, Switzerland.
Brancucci NMB; Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, 4051, Basel, Switzerland.; University of Basel, 4001, Basel, Switzerland.
Voss TS; Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, 4051, Basel, Switzerland. .; University of Basel, 4001, Basel, Switzerland. .
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Źródło :
Communications biology [Commun Biol] 2021 Mar 12; Vol. 4 (1), pp. 336. Date of Electronic Publication: 2021 Mar 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gametogenesis*
Casein Kinase II/*metabolism
Erythrocytes/*parasitology
Plasmodium falciparum/*metabolism
Protozoan Proteins/*metabolism
Antimalarials/pharmacology ; CRISPR-Cas Systems ; Casein Kinase II/antagonists & inhibitors ; Casein Kinase II/genetics ; Catalytic Domain ; Gene Editing ; Humans ; Life Cycle Stages ; Plasmodium falciparum/drug effects ; Plasmodium falciparum/genetics ; Plasmodium falciparum/growth & development ; Protein Kinase Inhibitors/pharmacology ; Protozoan Proteins/genetics ; Reproduction, Asexual
Czasopismo naukowe
Tytuł :
Achieving effective and selective CK1 inhibitors through structure modification.
Autorzy :
Du C; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, People's Republic of China.
Yang H; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, People's Republic of China.
Feng F; Jiangsu Food & Pharmaceutical Science College, No.4 Meicheng Road, Huai'an 223003, People's Republic of China.; Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, People's Republic of China.
Liu W; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, People's Republic of China.
Chen Y; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, People's Republic of China.
Sun H; Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 211198, People's Republic of China.; Jiangsu Food & Pharmaceutical Science College, No.4 Meicheng Road, Huai'an 223003, People's Republic of China.
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Źródło :
Future medicinal chemistry [Future Med Chem] 2021 Mar; Vol. 13 (5), pp. 505-528. Date of Electronic Publication: 2021 Jan 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Casein Kinase I/*antagonists & inhibitors
Protein Kinase Inhibitors/*chemistry
Binding Sites ; Casein Kinase I/metabolism ; Humans ; Imidazoles/chemistry ; Imidazoles/metabolism ; Imidazoles/therapeutic use ; Molecular Dynamics Simulation ; Neoplasms/drug therapy ; Neoplasms/pathology ; Neurodegenerative Diseases/drug therapy ; Neurodegenerative Diseases/pathology ; Oxindoles/chemistry ; Oxindoles/metabolism ; Oxindoles/therapeutic use ; Protein Isoforms/antagonists & inhibitors ; Protein Isoforms/metabolism ; Protein Kinase Inhibitors/metabolism ; Protein Kinase Inhibitors/therapeutic use
Czasopismo naukowe
Tytuł :
Contribution of the CK2 Catalytic Isoforms α and α' to the Glycolytic Phenotype of Tumor Cells.
Autorzy :
Zonta F; Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy.; CNR Neuroscience Institute, 35131 Padova, Italy.
Borgo C; Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy.
Quezada Meza CP; Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy.; CNR Neuroscience Institute, 35131 Padova, Italy.
Masgras I; CNR Neuroscience Institute, 35131 Padova, Italy.
Rasola A; Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy.
Salvi M; Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy.
Pinna LA; Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy.; CNR Neuroscience Institute, 35131 Padova, Italy.
Ruzzene M; Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy.; CNR Neuroscience Institute, 35131 Padova, Italy.
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Źródło :
Cells [Cells] 2021 Jan 18; Vol. 10 (1). Date of Electronic Publication: 2021 Jan 18.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Glycolysis*
Casein Kinase II/*metabolism
Neoplasm Proteins/*metabolism
Neoplasms/*enzymology
Casein Kinase II/genetics ; Cell Line, Tumor ; Humans ; Isoenzymes/genetics ; Isoenzymes/metabolism ; Neoplasm Proteins/genetics ; Neoplasms/genetics ; Neoplasms/pathology
Czasopismo naukowe
Tytuł :
In vitro identification of imidazo[1,2-a]pyrazine-based antileishmanial agents and evaluation of L. major casein kinase 1 inhibition.
Autorzy :
Bazin MA; Université de Nantes, Cibles et Médicaments des Infections et du Cancer, IICiMed, EA 1155, F-44000, Nantes, France.
Cojean S; BioCIS Biomolécules: Conception, Isolement, Synthèse, Chimiothérapie Antiparasitaire, UMR CNRS 8076, Univ. Paris-Sud, Université Paris-Saclay, Faculté de Pharmacie, F-92296, Châtenay-Malabry, France.
Pagniez F; Université de Nantes, Cibles et Médicaments des Infections et du Cancer, IICiMed, EA 1155, F-44000, Nantes, France.
Bernadat G; BioCIS Biomolécules: Conception, Isolement, Synthèse, Chimiothérapie Antiparasitaire, UMR CNRS 8076, Univ. Paris-Sud, Université Paris-Saclay, Faculté de Pharmacie, F-92296, Châtenay-Malabry, France.
Cavé C; BioCIS Biomolécules: Conception, Isolement, Synthèse, Chimiothérapie Antiparasitaire, UMR CNRS 8076, Univ. Paris-Sud, Université Paris-Saclay, Faculté de Pharmacie, F-92296, Châtenay-Malabry, France.
Ourliac-Garnier I; Université de Nantes, Cibles et Médicaments des Infections et du Cancer, IICiMed, EA 1155, F-44000, Nantes, France.
Nourrisson MR; Université de Nantes, Cibles et Médicaments des Infections et du Cancer, IICiMed, EA 1155, F-44000, Nantes, France.
Morgado C; Université de Nantes, Cibles et Médicaments des Infections et du Cancer, IICiMed, EA 1155, F-44000, Nantes, France.
Picot C; Université de Nantes, Cibles et Médicaments des Infections et du Cancer, IICiMed, EA 1155, F-44000, Nantes, France.
Leclercq O; Institut Pasteur and Institut National de Santé et Recherche Médicale INSERM U1201, Unité de Parasitologie Moléculaire et Signalisation, F-75015, Paris, France.
Baratte B; Sorbonne Université, CNRS, UMR8227, Integrative Biology of Marine Models Laboratory (LBI2M), Station Biologique de Roscoff, F-29680, Roscoff, France; Sorbonne Université, CNRS, FR2424, Kinase Inhibitor Specialized Screening Facility - KISSf, Station Biologique, F-29680, Roscoff, France.
Robert T; Sorbonne Université, CNRS, UMR8227, Integrative Biology of Marine Models Laboratory (LBI2M), Station Biologique de Roscoff, F-29680, Roscoff, France; Sorbonne Université, CNRS, FR2424, Kinase Inhibitor Specialized Screening Facility - KISSf, Station Biologique, F-29680, Roscoff, France.
Späth GF; Institut Pasteur and Institut National de Santé et Recherche Médicale INSERM U1201, Unité de Parasitologie Moléculaire et Signalisation, F-75015, Paris, France.
Rachidi N; Institut Pasteur and Institut National de Santé et Recherche Médicale INSERM U1201, Unité de Parasitologie Moléculaire et Signalisation, F-75015, Paris, France.
Bach S; Sorbonne Université, CNRS, UMR8227, Integrative Biology of Marine Models Laboratory (LBI2M), Station Biologique de Roscoff, F-29680, Roscoff, France; Sorbonne Université, CNRS, FR2424, Kinase Inhibitor Specialized Screening Facility - KISSf, Station Biologique, F-29680, Roscoff, France.
Loiseau PM; BioCIS Biomolécules: Conception, Isolement, Synthèse, Chimiothérapie Antiparasitaire, UMR CNRS 8076, Univ. Paris-Sud, Université Paris-Saclay, Faculté de Pharmacie, F-92296, Châtenay-Malabry, France.
Le Pape P; Université de Nantes, Cibles et Médicaments des Infections et du Cancer, IICiMed, EA 1155, F-44000, Nantes, France.
Marchand P; Université de Nantes, Cibles et Médicaments des Infections et du Cancer, IICiMed, EA 1155, F-44000, Nantes, France. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Jan 15; Vol. 210, pp. 112956. Date of Electronic Publication: 2020 Oct 23.
Typ publikacji :
Journal Article
MeSH Terms :
Casein Kinase I/*antagonists & inhibitors
Imidazoles/*pharmacology
Leishmania major/*enzymology
Pyrazines/*pharmacology
Trypanocidal Agents/*pharmacology
Casein Kinase I/metabolism ; Humans ; Imidazoles/chemistry ; Leishmania major/drug effects ; Leishmania major/metabolism ; Leishmaniasis/drug therapy ; Leishmaniasis/parasitology ; Models, Molecular ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/pharmacology ; Pyrazines/chemistry ; Trypanocidal Agents/chemistry
Czasopismo naukowe
Tytuł :
Transcriptional Regulation of PIK3CD and PIKFYVE in T-Cell Acute Lymphoblastic Leukemia by IKAROS and Protein Kinase CK2.
Autorzy :
Dovat E; Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Song C; Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.; Ohio State University School of Medicine, Columbus, OH 43210, USA.
Hu T; Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Rahman MA; Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Dhanyamraju PK; Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Klink M; Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Bogush D; Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Soliman M; Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Kane S; Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
McGrath M; Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Ding Y; Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Desai D; Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Sharma A; Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Gowda C; Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Jan 15; Vol. 22 (2). Date of Electronic Publication: 2021 Jan 15.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation, Leukemic*
Casein Kinase II/*genetics
Class I Phosphatidylinositol 3-Kinases/*genetics
Ikaros Transcription Factor/*genetics
Phosphatidylinositol 3-Kinases/*genetics
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/*genetics
Casein Kinase II/antagonists & inhibitors ; Casein Kinase II/metabolism ; Cell Line, Tumor ; Chromatin Assembly and Disassembly/genetics ; Class I Phosphatidylinositol 3-Kinases/metabolism ; HEK293 Cells ; Humans ; Ikaros Transcription Factor/metabolism ; Naphthyridines/pharmacology ; Phenazines/pharmacology ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphorylation/drug effects ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/metabolism ; Promoter Regions, Genetic/genetics ; Protein Binding ; Signal Transduction/genetics
Czasopismo naukowe

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