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Tytuł:
Casein Kinase 1 Phosphomimetic Mutations Negatively Impact Connexin-43 Gap Junctions in Human Pluripotent Stem Cell-Derived Cardiomyocytes.
Autorzy:
Al-Attar R; McEwen Stem Cell Institute, University Health Network, Toronto, ON M5G 1L7, Canada.
Jargstorf J; McEwen Stem Cell Institute, University Health Network, Toronto, ON M5G 1L7, Canada.
Romagnuolo R; McEwen Stem Cell Institute, University Health Network, Toronto, ON M5G 1L7, Canada.
Jouni M; McEwen Stem Cell Institute, University Health Network, Toronto, ON M5G 1L7, Canada.
Alibhai FJ; McEwen Stem Cell Institute, University Health Network, Toronto, ON M5G 1L7, Canada.
Lampe PD; Translational Research Program, Public Health Sciences and Human Biology Divisions, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Solan JL; Translational Research Program, Public Health Sciences and Human Biology Divisions, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Laflamme MA; McEwen Stem Cell Institute, University Health Network, Toronto, ON M5G 1L7, Canada.; Peter Munk Cardiac Centre, University Health Network, Toronto, ON M5G 1L7, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5G 1L7, Canada.
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Źródło:
Biomolecules [Biomolecules] 2024 Jan 02; Vol. 14 (1). Date of Electronic Publication: 2024 Jan 02.
Typ publikacji:
Journal Article
MeSH Terms:
Casein Kinase I*/genetics
Connexin 43*/genetics
Myocytes, Cardiac*
Adult ; Animals ; Humans ; Mice ; Connexins ; Gap Junctions ; Mice, Transgenic ; Mutation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The conserved C-terminal residues of FAM83H are required for the recruitment of casein kinase 1 to the keratin cytoskeleton.
Autorzy:
Kuga T; Laboratory of Analytics for Biomolecules, Faculty of Pharmaceutical Science, Setsunan University, 45-1 Nagaotoge-cho, Hirakata-shi, Osaka, 573-0101, Japan. .
Inoue N; Laboratory of Analytics for Biomolecules, Faculty of Pharmaceutical Science, Setsunan University, 45-1 Nagaotoge-cho, Hirakata-shi, Osaka, 573-0101, Japan.
Sometani K; Laboratory of Analytics for Biomolecules, Faculty of Pharmaceutical Science, Setsunan University, 45-1 Nagaotoge-cho, Hirakata-shi, Osaka, 573-0101, Japan.
Murataka S; Laboratory of Analytics for Biomolecules, Faculty of Pharmaceutical Science, Setsunan University, 45-1 Nagaotoge-cho, Hirakata-shi, Osaka, 573-0101, Japan.
Saraya M; Laboratory of Analytics for Biomolecules, Faculty of Pharmaceutical Science, Setsunan University, 45-1 Nagaotoge-cho, Hirakata-shi, Osaka, 573-0101, Japan.
Sugita R; Laboratory of Analytics for Biomolecules, Faculty of Pharmaceutical Science, Setsunan University, 45-1 Nagaotoge-cho, Hirakata-shi, Osaka, 573-0101, Japan.
Mikami T; Pax Creation Medical Lab., LLC, Iwate, 020-0805, Japan.
Takeda Y; Division of Clinical Pathology, Department of Reconstructive Oral and Maxillofacial Surgery, School of Dentistry, Iwate Medical University, Iwate, 028-3694, Japan.
Taniguchi M; Laboratory of Analytics for Biomolecules, Faculty of Pharmaceutical Science, Setsunan University, 45-1 Nagaotoge-cho, Hirakata-shi, Osaka, 573-0101, Japan.
Nishida K; Department of Integrative Pharmaceutical Sciences, Faculty of Pharmaceutical Science, Setsunan University, Osaka, 573-0101, Japan.
Yamagishi N; Laboratory of Analytics for Biomolecules, Faculty of Pharmaceutical Science, Setsunan University, 45-1 Nagaotoge-cho, Hirakata-shi, Osaka, 573-0101, Japan.
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Źródło:
Scientific reports [Sci Rep] 2022 Jul 12; Vol. 12 (1), pp. 11819. Date of Electronic Publication: 2022 Jul 12.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Casein Kinase I*/genetics
Casein Kinase I*/metabolism
Keratins*/genetics
Keratins*/metabolism
Amino Acids/metabolism ; Animals ; Casein Kinases/metabolism ; Cytoskeleton/metabolism ; Microtubules/metabolism ; Mutant Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Potential Role of Protein Kinase FAM20C on the Brain in Raine Syndrome, an In Silico Analysis.
Autorzy:
Palma-Lara I; Laboratorio de Morfología Celular y Molecular, Escuela Superior de Medicina, Instituto Politécnico Nacional, Ciudad de México 11340, Mexico.
García Alonso-Themann P; Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Ciudad de México 11000, Mexico.
Pérez-Durán J; Instituto Nacional de Perinatología Isidro Espinosa de los Reyes, Ciudad de México 11000, Mexico.
Godínez-Aguilar R; División de Investigación, Hospital Juárez de México, Ciudad de México 11340, Mexico.
Bonilla-Delgado J; Unidad de Investigación, Hospital Regional de Ixtapaluca, Ixtapaluca 56530, Mexico.; Departamento de Biotecnología, Escuela de Ingeniería y Ciencias, Instituto Tecnológico de Monterrey, Toluca de Lerdo 50110, Mexico.
Gómez-Archila D; Departamento de Oncología Quirúrgica, Hospital de Gineco-Obstetricia 3, Centro Médico Nacional 'La Raza', Ciudad de México 02990, Mexico.
Espinosa-García AM; Laboratorio de Farmacología Clínica, Hospital General de México, Ciudad de México 06720, Mexico.
Nolasco-Quiroga M; Coordinación de Enseñanza e Investigación, Clínica Hospital Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Huauchinango 73177, Mexico.
Victoria-Acosta G; División de Investigación, Hospital Juárez de México, Ciudad de México 11340, Mexico.
López-Ornelas A; División de Investigación, Hospital Juárez de México, Ciudad de México 11340, Mexico.
Serrano-Bello JC; Departamento de Patología Clínica y Experimental, Hospital Infantil de México Federico Gómez, Ciudad de México 06720, Mexico.
Olguín-García MG; Centro Dermatológico 'Dr. Ladislao de la Pascua', Ciudad de México 06780, Mexico.
Palacios-Reyes C; División de Investigación, Hospital Juárez de México, Ciudad de México 11340, Mexico.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2023 May 17; Vol. 24 (10). Date of Electronic Publication: 2023 May 17.
Typ publikacji:
Journal Article
MeSH Terms:
Protein Kinases*/metabolism
Microcephaly*/genetics
Humans ; Brain/metabolism ; Protein Serine-Threonine Kinases/metabolism ; Extracellular Matrix Proteins/genetics ; Extracellular Matrix Proteins/metabolism ; Casein Kinase I/genetics ; Casein Kinase I/metabolism
SCR Disease Name:
Raine syndrome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
FAM20C Overview: Classic and Novel Targets, Pathogenic Variants and Raine Syndrome Phenotypes.
Autorzy:
Palma-Lara I; Laboratorio de Morfología Celular y Molecular, Sección de Estudios de Posgrado e Investigación, Instituto Politécnico Nacional, Escuela Superior de Medicina, Ciudad de México 11340, Mexico.
Pérez-Ramírez M; Laboratorio de Morfología Celular y Molecular, Sección de Estudios de Posgrado e Investigación, Instituto Politécnico Nacional, Escuela Superior de Medicina, Ciudad de México 11340, Mexico.
García Alonso-Themann P; Instituto Nacional de Perinatología, Seguimiento Pediátrico, Ciudad de México 11000, Mexico.
Espinosa-García AM; Laboratorio de Farmacología Clínica, Hospital General de México, Ciudad de México 06720, Mexico.
Godinez-Aguilar R; División de Investigación, Hospital Juárez de México, Ciudad de México 07760, Mexico.
Bonilla-Delgado J; División de Investigación, Hospital Juárez de México, Ciudad de México 07760, Mexico.
López-Ornelas A; División de Investigación, Hospital Juárez de México, Ciudad de México 07760, Mexico.
Victoria-Acosta G; División de Investigación, Hospital Juárez de México, Ciudad de México 07760, Mexico.
Olguín-García MG; Centro Dermatológico 'Dr. Ladislao de la Pascua' SSPCDMX, Departamento de Educación e Investigación, Ciudad de México 06780, Mexico.
Moreno J; División de Investigación, Hospital Juárez de México, Ciudad de México 07760, Mexico.
Palacios-Reyes C; División de Investigación, Hospital Juárez de México, Ciudad de México 07760, Mexico.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2021 Jul 27; Vol. 22 (15). Date of Electronic Publication: 2021 Jul 27.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Abnormalities, Multiple*/genetics
Abnormalities, Multiple*/metabolism
Abnormalities, Multiple*/mortality
Abnormalities, Multiple*/pathology
Casein Kinase I*/genetics
Casein Kinase I*/metabolism
Cleft Palate*/genetics
Cleft Palate*/metabolism
Cleft Palate*/mortality
Cleft Palate*/pathology
Exophthalmos*/genetics
Exophthalmos*/metabolism
Exophthalmos*/mortality
Exophthalmos*/pathology
Extracellular Matrix Proteins*/genetics
Extracellular Matrix Proteins*/metabolism
Genetic Variation*
Microcephaly*/genetics
Microcephaly*/metabolism
Microcephaly*/mortality
Microcephaly*/pathology
Osteosclerosis*/genetics
Osteosclerosis*/metabolism
Osteosclerosis*/mortality
Osteosclerosis*/pathology
Phenotype*
Humans
SCR Disease Name:
Raine syndrome
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Genome-wide identification, evolutionary estimation and functional characterization of two cotton CKI gene types.
Autorzy:
Li Y; National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan , 430070, Hubei, China.
Li Y; National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan , 430070, Hubei, China.; College of Life Sciences, State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, South China Agricultural University, Guangzhou , 510642, Guangdong, China.
Chen Y; National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan , 430070, Hubei, China.
Wang M; National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan , 430070, Hubei, China.
Yang J; Institute of Economic Crops, Xinjiang Academy of Agricultural Sciences, Xinjiang, 830091, China.
Zhang X; National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan , 430070, Hubei, China.
Zhu L; National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan , 430070, Hubei, China.
Kong J; Institute of Economic Crops, Xinjiang Academy of Agricultural Sciences, Xinjiang, 830091, China. .
Min L; National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan , 430070, Hubei, China. .
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Źródło:
BMC plant biology [BMC Plant Biol] 2021 May 22; Vol. 21 (1), pp. 229. Date of Electronic Publication: 2021 May 22.
Typ publikacji:
Journal Article
MeSH Terms:
Evolution, Molecular*
Casein Kinase I/*genetics
Gossypium/*genetics
Plant Proteins/*genetics
Casein Kinase I/metabolism ; Genome, Plant ; Gossypium/growth & development ; Gossypium/metabolism ; Plant Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Casein kinase TbCK1.2 regulates division of kinetoplast DNA, and movement of basal bodies in the African trypanosome.
Autorzy:
Sullenberger C; Department of Cellular Biology, University of Georgia, Athens, GA, United States of America.
Hoffman B; Department of Cellular Biology, University of Georgia, Athens, GA, United States of America.
Wiedeman J; Department of Cellular Biology, University of Georgia, Athens, GA, United States of America.
Kumar G; Department of Cellular Biology, University of Georgia, Athens, GA, United States of America.
Mensa-Wilmot K; Department of Cellular Biology, University of Georgia, Athens, GA, United States of America.; Department of Molecular and Cellular Biology, Kennesaw State University, Kennesaw, GA, United States of America.; Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, GA, United States of America.
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Źródło:
PloS one [PLoS One] 2021 Apr 16; Vol. 16 (4), pp. e0249908. Date of Electronic Publication: 2021 Apr 16 (Print Publication: 2021).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Basal Bodies/*physiology
Casein Kinase I/*metabolism
DNA, Kinetoplast/*metabolism
Protozoan Proteins/*metabolism
Trypanosoma brucei brucei/*metabolism
Casein Kinase I/antagonists & inhibitors ; Casein Kinase I/genetics ; Cytokinesis/physiology ; Cytoplasm/metabolism ; DNA Cleavage ; DNA Replication ; Mitochondria/metabolism ; RNA Interference ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Signal Transduction
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Targeting Casein Kinase 1 (CK1) in Hematological Cancers.
Autorzy:
Janovská P; Department of Experimental Biology, Faculty of Science, Masaryk University, 62500 Brno, Czech Republic.
Normant E; TG Therapeutics, New York, NY 10014, USA.
Miskin H; TG Therapeutics, New York, NY 10014, USA.
Bryja V; Department of Experimental Biology, Faculty of Science, Masaryk University, 62500 Brno, Czech Republic.; Department of Cytokinetics, Institute of Biophysics, Academy of Sciences of the Czech Republic, 61265 Brno, Czech Republic.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Nov 27; Vol. 21 (23). Date of Electronic Publication: 2020 Nov 27.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Molecular Targeted Therapy*
Casein Kinase I/*metabolism
Hematologic Neoplasms/*drug therapy
Hematologic Neoplasms/*enzymology
Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Casein Kinase I/antagonists & inhibitors ; Casein Kinase I/chemistry ; Hematologic Neoplasms/pathology ; Humans ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Wnt Signaling Pathway
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Casein kinase 1 gamma regulates oxidative stress response via interacting with the NADPH dual oxidase complex.
Autorzy:
Hu Y; Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.
Xu Z; Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.
Pan Q; Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.
Ma L; Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.; Hunan Key Laboratory of Animal Models for Human Diseases, Central South University, Changsha, Hunan, China.; Hunan Key Laboratory of Medical Genetics, Central South University, Changsha, Hunan, China.; The Key Laboratory of Precision Molecular Medicine of Hunan Province, Central South University, Changsha, Hunan, China.
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Źródło:
PLoS genetics [PLoS Genet] 2023 Apr 26; Vol. 19 (4), pp. e1010740. Date of Electronic Publication: 2023 Apr 26 (Print Publication: 2023).
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Caenorhabditis elegans*/metabolism
Caenorhabditis elegans Proteins*/genetics
Caenorhabditis elegans Proteins*/metabolism
Animals ; Humans ; Dual Oxidases/pharmacology ; NADP ; Reactive Oxygen Species ; Casein Kinase I/genetics ; Oxidative Stress/genetics ; NADPH Oxidases ; Tetraspanins/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Astrocytes deliver CK1 to neurons via extracellular vesicles in response to inflammation promoting the translation and amyloidogenic processing of APP.
Autorzy:
Li Z; Department of Neurology, Richard T. Johnson Division of Neuroimmunology and Neurological Infections Johns Hopkins University School of Medicine Baltimore Maryland USA.
Moniruzzaman M; Department of Neurology, Richard T. Johnson Division of Neuroimmunology and Neurological Infections Johns Hopkins University School of Medicine Baltimore Maryland USA.
Dastgheyb RM; Department of Neurology, Richard T. Johnson Division of Neuroimmunology and Neurological Infections Johns Hopkins University School of Medicine Baltimore Maryland USA.
Yoo SW; Department of Neurology, Richard T. Johnson Division of Neuroimmunology and Neurological Infections Johns Hopkins University School of Medicine Baltimore Maryland USA.
Wang M; Department of Neurology, Richard T. Johnson Division of Neuroimmunology and Neurological Infections Johns Hopkins University School of Medicine Baltimore Maryland USA.
Hao H; Advanced Science Research Center at the Graduate Center, Neuroscience Initiative City University of New York New York New York USA.
Liu J; Advanced Science Research Center at the Graduate Center, Neuroscience Initiative City University of New York New York New York USA.
Casaccia P; Advanced Science Research Center at the Graduate Center, Neuroscience Initiative City University of New York New York New York USA.
Nogueras-Ortiz C; Laboratory of Clinical Investigation National Institute on Aging Baltimore Maryland USA.
Kapogiannis D; Laboratory of Clinical Investigation National Institute on Aging Baltimore Maryland USA.
Slusher BS; Department of Neurology, Richard T. Johnson Division of Neuroimmunology and Neurological Infections Johns Hopkins University School of Medicine Baltimore Maryland USA.; Johns Hopkins Drug Discovery Johns Hopkins University School of Medicine Baltimore Maryland USA.
Haughey NJ; Department of Neurology, Richard T. Johnson Division of Neuroimmunology and Neurological Infections Johns Hopkins University School of Medicine Baltimore Maryland USA.
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Źródło:
Journal of extracellular vesicles [J Extracell Vesicles] 2020 Dec; Vol. 10 (2), pp. e12035. Date of Electronic Publication: 2020 Dec 31.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural
MeSH Terms:
Alzheimer Disease/*pathology
Amyloid beta-Protein Precursor/*metabolism
Astrocytes/*metabolism
Casein Kinase I/*metabolism
Extracellular Vesicles/*metabolism
Inflammation/*pathology
Interleukin-1beta/*pharmacology
Neurons/*metabolism
Aged ; Aged, 80 and over ; Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Amyloid/chemistry ; Amyloid/drug effects ; Amyloid beta-Protein Precursor/genetics ; Animals ; Astrocytes/drug effects ; Astrocytes/immunology ; Case-Control Studies ; Casein Kinase I/genetics ; Extracellular Vesicles/drug effects ; Extracellular Vesicles/immunology ; Female ; Fragile X Mental Retardation Protein/genetics ; Fragile X Mental Retardation Protein/metabolism ; Glycogen Synthase Kinase 3/genetics ; Glycogen Synthase Kinase 3/metabolism ; Humans ; Inflammation/genetics ; Inflammation/immunology ; Inflammation/metabolism ; Male ; Middle Aged ; Neurons/drug effects ; Neurons/immunology ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Casein kinase 1.2 over expression restores stress resistance to Leishmania donovani HSP23 null mutants.
Autorzy:
Kröber-Boncardo C; Leishmania Group, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht St 74, 20359, Hamburg, Germany.
Lorenzen S; Department of Epidemiology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
Brinker C; Leishmania Group, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht St 74, 20359, Hamburg, Germany.
Clos J; Leishmania Group, Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht St 74, 20359, Hamburg, Germany. .
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Źródło:
Scientific reports [Sci Rep] 2020 Sep 29; Vol. 10 (1), pp. 15969. Date of Electronic Publication: 2020 Sep 29.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Mutation*
Up-Regulation*
Casein Kinase I/*genetics
Heat-Shock Proteins, Small/*genetics
Leishmania donovani/*growth & development
Casein Kinase I/metabolism ; Chromosome Mapping ; Heat-Shock Proteins, Small/metabolism ; Leishmania donovani/genetics ; Leishmania donovani/metabolism ; Multigene Family ; Phenotype ; Phosphorylation ; Protozoan Proteins/genetics ; Protozoan Proteins/metabolism ; Stress, Physiological ; Whole Genome Sequencing
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders.
Autorzy:
Benek O; a University of Hradec Kralove, Faculty of Science, Department of Chemistry , Hradec Kralove , Czech Republic.; b University Hospital in Hradec Kralove, Biomedical Research Center , Hradec Kralove , Czech Republic.; c National Institute of Mental Health , Klecany , Czech Republic.
Hroch L; b University Hospital in Hradec Kralove, Biomedical Research Center , Hradec Kralove , Czech Republic.
Aitken L; d University of St. Andrews, Medical and Biological Sciences Building, School of Biology , St. Andrews , UK.
Gunn-Moore F; d University of St. Andrews, Medical and Biological Sciences Building, School of Biology , St. Andrews , UK.
Vinklarova L; a University of Hradec Kralove, Faculty of Science, Department of Chemistry , Hradec Kralove , Czech Republic.; b University Hospital in Hradec Kralove, Biomedical Research Center , Hradec Kralove , Czech Republic.
Kuca K; a University of Hradec Kralove, Faculty of Science, Department of Chemistry , Hradec Kralove , Czech Republic.; b University Hospital in Hradec Kralove, Biomedical Research Center , Hradec Kralove , Czech Republic.
Perez DI; e Centro de Investigaciones Biologicas-CSIC , Madrid , Spain.
Perez C; f Instituto de Quimica Medica-CSIC , Madrid , Spain.
Martinez A; e Centro de Investigaciones Biologicas-CSIC , Madrid , Spain.
Fisar Z; g Charles University and General University Hospital in Prague, First Faculty of Medicine, Department of Psychiatry , Prague , Czech Republic.
Musilek K; a University of Hradec Kralove, Faculty of Science, Department of Chemistry , Hradec Kralove , Czech Republic.; b University Hospital in Hradec Kralove, Biomedical Research Center , Hradec Kralove , Czech Republic.
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Źródło:
Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2018 Dec; Vol. 33 (1), pp. 665-670.
Typ publikacji:
Journal Article
MeSH Terms:
3-Hydroxyacyl CoA Dehydrogenases/*metabolism
Casein Kinase I/*antagonists & inhibitors
Enzyme Inhibitors/*pharmacology
Neurodegenerative Diseases/*drug therapy
Phenylurea Compounds/*pharmacology
Casein Kinase I/metabolism ; Dose-Response Relationship, Drug ; Enzyme Inhibitors/chemistry ; Humans ; Molecular Structure ; Neurodegenerative Diseases/metabolism ; Phenylurea Compounds/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
The Doubletime Homolog KIN-20 Mainly Regulates let-7 Independently of Its Effects on the Period Homolog LIN-42 in Caenorhabditis elegans .
Autorzy:
Rhodehouse K; Department of Biology, Colgate University, Hamilton, NY 13346.
Cascino K; Department of Biology, Colgate University, Hamilton, NY 13346.
Aseltine L; Department of Biology, Colgate University, Hamilton, NY 13346.
Padula A; Department of Biology, Colgate University, Hamilton, NY 13346.
Weinstein R; Department of Biology, Colgate University, Hamilton, NY 13346.
Spina JS; Department of Biology, Colgate University, Hamilton, NY 13346.
Olivero CE; Department of Biology, Colgate University, Hamilton, NY 13346.
Van Wynsberghe PM; Department of Biology, Colgate University, Hamilton, NY 13346 .
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Źródło:
G3 (Bethesda, Md.) [G3 (Bethesda)] 2018 Jul 31; Vol. 8 (8), pp. 2617-2629. Date of Electronic Publication: 2018 Jul 31.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Caenorhabditis elegans/*metabolism
Caenorhabditis elegans Proteins/*metabolism
Casein Kinase I/*metabolism
Casein Kinase Idelta/*metabolism
MicroRNAs/*genetics
Transcription Factors/*metabolism
Animals ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans Proteins/genetics ; Casein Kinase I/genetics ; Casein Kinase Idelta/genetics ; MicroRNAs/metabolism ; Transcription Factors/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
FAM20C could be targeted by TET1 to promote odontoblastic differentiation potential of human dental pulp cells.
Autorzy:
Li Q; Hospital of Stomatology & Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, China.
Yi B; Hospital of Stomatology & Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, China.
Feng Z; Hospital of Stomatology & Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, China.
Meng R; Hospital of Stomatology & Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, China.
Tian C; Hospital of Stomatology & Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, China.
Xu Q; Hospital of Stomatology & Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, China.
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Źródło:
Cell proliferation [Cell Prolif] 2018 Apr; Vol. 51 (2), pp. e12426. Date of Electronic Publication: 2017 Dec 25.
Typ publikacji:
Journal Article
MeSH Terms:
Calcification, Physiologic*
Cell Differentiation*
Gene Expression Regulation, Enzymologic*
Casein Kinase I/*biosynthesis
Dental Pulp/*enzymology
Extracellular Matrix Proteins/*biosynthesis
Mixed Function Oxygenases/*biosynthesis
Odontoblasts/*enzymology
Proto-Oncogene Proteins/*biosynthesis
Adolescent ; Adult ; Casein Kinase I/genetics ; Dental Pulp/cytology ; Extracellular Matrix Proteins/genetics ; Female ; Gene Knockdown Techniques ; Humans ; Male ; Methylation ; Mixed Function Oxygenases/genetics ; Odontoblasts/cytology ; Promoter Regions, Genetic ; Proto-Oncogene Proteins/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Assessing the Inhibitory Potential of Kinase Inhibitors In Vitro: Major Pitfalls and Suggestions for Improving Comparability of Data Using CK1 Inhibitors as an Example.
Autorzy:
Roth A; Department of General and Visceral Surgery, Surgery Center, Ulm University Medical Center, Albert-Einstein-Allee 23, 89081 Ulm, Germany.
Gihring A; Department of General and Visceral Surgery, Surgery Center, Ulm University Medical Center, Albert-Einstein-Allee 23, 89081 Ulm, Germany.
Göser F; Department of General and Visceral Surgery, Surgery Center, Ulm University Medical Center, Albert-Einstein-Allee 23, 89081 Ulm, Germany.
Peifer C; Institute of Pharmacy, Christian-Albrechts-University of Kiel, Gutenbergstraße 76, 24118 Kiel, Germany.
Knippschild U; Department of General and Visceral Surgery, Surgery Center, Ulm University Medical Center, Albert-Einstein-Allee 23, 89081 Ulm, Germany.
Bischof J; Department of General and Visceral Surgery, Surgery Center, Ulm University Medical Center, Albert-Einstein-Allee 23, 89081 Ulm, Germany.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2021 Aug 12; Vol. 26 (16). Date of Electronic Publication: 2021 Aug 12.
Typ publikacji:
Journal Article
MeSH Terms:
Casein Kinase I/*antagonists & inhibitors
Enzyme Assays/*methods
Protein Kinase Inhibitors/*chemistry
In Vitro Techniques ; Inhibitory Concentration 50 ; Kinetics ; Phosphorylation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Lack of Casein Kinase 1 Delta Promotes Genomic Instability - The Accumulation of DNA Damage and Down-Regulation of Checkpoint Kinase 1.
Autorzy:
Greer YE; Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland, United States of America.; Women's Malignancies Branch, National Cancer Institute, Bethesda, Maryland, United States of America.
Gao B; Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland, United States of America.
Yang Y; Genetic Disease Research Branch, National Human Genome Research Institute, Bethesda, Maryland, United States of America.
Nussenzweig A; Laboratory of Genome Integrity, National Cancer Institute, Bethesda, Maryland, United States of America.
Rubin JS; Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, Maryland, United States of America.
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Źródło:
PloS one [PLoS One] 2017 Jan 26; Vol. 12 (1), pp. e0170903. Date of Electronic Publication: 2017 Jan 26 (Print Publication: 2017).
Typ publikacji:
Journal Article
MeSH Terms:
DNA Damage*
Down-Regulation*
Genomic Instability*
Casein Kinase I/*genetics
Checkpoint Kinase 1/*genetics
Animals ; Casein Kinase I/metabolism ; Cell Line, Tumor ; Checkpoint Kinase 1/metabolism ; Fibroblasts/metabolism ; Humans ; Mice ; Mice, Knockout ; Mitosis/genetics ; Phosphorylation
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Systems genetic and pharmacological analysis identifies candidate genes underlying mechanosensation in the von Frey test.
Autorzy:
Young EE; Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.; School of Nursing, University of Connecticut, Storrs, CT, USA.; Institute for Systems Genomics, University of Connecticut, Storrs, CT, USA.
Bryant CD; Department of Pharmacology and Experimental Therapeutics and Department of Psychiatry, Boston University School of Medicine, Boston, MA, USA.
Lee SE; Department of Neuroscience & Cell Biology, University of Texas Medical Branch, Galveston, TX, USA.
Peng X; Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Cook B; Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Nair HK; Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Dreher KJ; Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Zhang X; Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Palmer AA; Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA.; Department of Human Genetics, University of Chicago, Chicago, IL, USA.; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA.
Chung JM; Department of Neuroscience & Cell Biology, University of Texas Medical Branch, Galveston, TX, USA.
Mogil JS; Department of Psychology and Alan Edwards Centre for Research on Pain, McGill University, Montreal, Canada.
Chesler EJ; Mammalian Genetics & Genomics, Oak Ridge National Laboratory, Oak Ridge, TN, USA.; The Jackson Laboratory, Bar Harbor, ME, USA.
Lariviere WR; Department of Anesthesiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
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Źródło:
Genes, brain, and behavior [Genes Brain Behav] 2016 Jul; Vol. 15 (6), pp. 604-15.
Typ publikacji:
Journal Article
MeSH Terms:
Calcium Channels/*genetics
Casein Kinase I/*genetics
Mechanotransduction, Cellular/*genetics
rab GTP-Binding Proteins/*genetics
Amines/pharmacology ; Analgesics/pharmacology ; Animals ; Calcium Channels/metabolism ; Casein Kinase I/metabolism ; Cyclohexanecarboxylic Acids/pharmacology ; Gabapentin ; Ganglia, Spinal/drug effects ; Ganglia, Spinal/metabolism ; Ganglia, Spinal/physiology ; Male ; Mice ; Pyrimidines/pharmacology ; Quantitative Trait Loci ; Sensory Thresholds ; Touch/drug effects ; Touch/genetics ; gamma-Aminobutyric Acid/pharmacology ; rab GTP-Binding Proteins/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Regulation of Smoothened Phosphorylation and High-Level Hedgehog Signaling Activity by a Plasma Membrane Associated Kinase.
Autorzy:
Li S; Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America.; Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America.
Li S; Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America.; Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America.
Han Y; Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America.; Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America.
Tong C; Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America.
Wang B; Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America.; Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America.
Chen Y; Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America.; Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
Jiang J; Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America.; Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America.; Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America.
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Źródło:
PLoS biology [PLoS Biol] 2016 Jun 09; Vol. 14 (6), pp. e1002481. Date of Electronic Publication: 2016 Jun 09 (Print Publication: 2016).
Typ publikacji:
Journal Article
MeSH Terms:
Signal Transduction*
Casein Kinase I/*metabolism
Cell Membrane/*metabolism
Drosophila Proteins/*metabolism
Hedgehog Proteins/*metabolism
Smoothened Receptor/*metabolism
Animals ; Animals, Genetically Modified ; Binding Sites/genetics ; Blotting, Western ; Casein Kinase I/genetics ; Cell Line ; Cilia/genetics ; Cilia/metabolism ; Cyclic AMP-Dependent Protein Kinases/genetics ; Cyclic AMP-Dependent Protein Kinases/metabolism ; Drosophila Proteins/genetics ; Drosophila melanogaster/cytology ; Drosophila melanogaster/genetics ; Drosophila melanogaster/metabolism ; Fluorescence Resonance Energy Transfer ; Hedgehog Proteins/genetics ; Luminescent Proteins/genetics ; Luminescent Proteins/metabolism ; Microscopy, Confocal ; Mutation ; Phosphorylation ; RNA Interference ; Smoothened Receptor/genetics ; Wings, Animal/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
FAM83H and casein kinase I regulate the organization of the keratin cytoskeleton and formation of desmosomes.
Autorzy:
Kuga T; Department of Biochemistry &Molecular Biology, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8414, Japan.
Sasaki M; Laboratory of Animal Models for Human Diseases, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Osaka 567-0085, Japan.
Mikami T; Division of Anatomical and Cellular Pathology, Department of Pathology, Iwate Medical University, Shiwa-gun, Iwate 028-3694, Japan.
Miake Y; Department of Histology and Developmental Biology, Tokyo Dental College, Chiyoda-ku, Tokyo 101-0061, Japan.
Adachi J; Laboratory of Proteome Research, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Osaka 567-0085, Japan.
Shimizu M; Laboratory of Proteome Research, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Osaka 567-0085, Japan.
Saito Y; Department of Biochemistry &Molecular Biology, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8414, Japan.
Koura M; Laboratory of Animal Models for Human Diseases, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Osaka 567-0085, Japan.
Takeda Y; Division of Anatomical and Cellular Pathology, Department of Pathology, Iwate Medical University, Shiwa-gun, Iwate 028-3694, Japan.
Matsuda J; Laboratory of Animal Models for Human Diseases, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Osaka 567-0085, Japan.
Tomonaga T; Laboratory of Proteome Research, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Osaka 567-0085, Japan.
Nakayama Y; Department of Biochemistry &Molecular Biology, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8414, Japan.
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Źródło:
Scientific reports [Sci Rep] 2016 May 25; Vol. 6, pp. 26557. Date of Electronic Publication: 2016 May 25.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Ameloblasts/*metabolism
Amelogenesis Imperfecta/*metabolism
Casein Kinase I/*metabolism
Cytoskeleton/*metabolism
Desmosomes/*metabolism
Keratins/*metabolism
Proteins/*metabolism
Ameloblasts/pathology ; Amelogenesis Imperfecta/genetics ; Amelogenesis Imperfecta/pathology ; Casein Kinase I/genetics ; Cell Line, Tumor ; Cytoskeleton/genetics ; Desmosomes/genetics ; Humans ; Keratins/genetics ; Mutation ; Proteins/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Potential for Protein Kinase Pharmacological Regulation in Flaviviridae Infections.
Autorzy:
Blázquez AB; Department of Biotechnology, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), 28040 Madrid, Spain.
Saiz JC; Department of Biotechnology, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), 28040 Madrid, Spain.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2020 Dec 15; Vol. 21 (24). Date of Electronic Publication: 2020 Dec 15.
Typ publikacji:
Journal Article; Review
MeSH Terms:
Flaviviridae Infections/*drug therapy
Hepacivirus/*drug effects
Hepatitis C, Chronic/*drug therapy
Protein Kinase Inhibitors/*pharmacology
Protein Kinases/*metabolism
Antiviral Agents/pharmacology ; Calcium-Calmodulin-Dependent Protein Kinases/antagonists & inhibitors ; Calcium-Calmodulin-Dependent Protein Kinases/metabolism ; Casein Kinase I/antagonists & inhibitors ; Casein Kinase I/metabolism ; Cyclin-Dependent Kinases/antagonists & inhibitors ; Cyclin-Dependent Kinases/metabolism ; Flaviviridae/drug effects ; Flaviviridae/enzymology ; Flaviviridae Infections/enzymology ; Hepacivirus/enzymology ; Hepacivirus/metabolism ; Hepatitis C, Chronic/metabolism ; Humans ; Phosphorylation ; Protein Serine-Threonine Kinases/antagonists & inhibitors ; Protein Serine-Threonine Kinases/metabolism ; Protein-Tyrosine Kinases/antagonists & inhibitors ; Protein-Tyrosine Kinases/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A Rationale for Drug Design Provided by Co-Crystal Structure of IC261 in Complex with Tubulin.
Autorzy:
Xian J; Department of Clinical Research Management, Innovation Center of Nursing Research, Nursing Key Laboratory of Sichuan Province, West China Hospital, Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, China.
Bu F; Department of Clinical Research Management, Innovation Center of Nursing Research, Nursing Key Laboratory of Sichuan Province, West China Hospital, Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, China.; Precision Medicine Research Center, Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Wang Y; Precision Medicine Research Center, Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Long F; Department of Pharmacy, Sichuan Cancer Hospital & Institution, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, China.
Zhang Z; Precision Medicine Research Center, Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Wu C; Department of Clinical Research Management, Innovation Center of Nursing Research, Nursing Key Laboratory of Sichuan Province, West China Hospital, Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, China.; Precision Medicine Research Center, Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Tao Y; Precision Medicine Research Center, Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Wang T; Department of Pharmacy, Sichuan Cancer Hospital & Institution, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610041, China.
Wang G; Department of Clinical Research Management, Innovation Center of Nursing Research, Nursing Key Laboratory of Sichuan Province, West China Hospital, Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu 610041, China.; Precision Medicine Research Center, Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
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Źródło:
Molecules (Basel, Switzerland) [Molecules] 2021 Feb 10; Vol. 26 (4). Date of Electronic Publication: 2021 Feb 10.
Typ publikacji:
Journal Article
MeSH Terms:
Drug Design*
Casein Kinase I/*antagonists & inhibitors
Indoles/*chemistry
Microtubules/*drug effects
Phloroglucinol/*analogs & derivatives
Tubulin/*chemistry
Animals ; Binding Sites ; Colchicine/chemistry ; Colchicine/metabolism ; Crystallography, X-Ray ; Indoles/metabolism ; Molecular Docking Simulation ; Phloroglucinol/chemistry ; Phloroglucinol/metabolism ; Protein Conformation ; Structure-Activity Relationship ; Swine ; Tubulin/metabolism ; Tubulin Modulators/chemistry ; Tubulin Modulators/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Wyświetlanie 1-20 z 363

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