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    Wyświetlanie 1-19 z 19
    Tytuł:
    Renal Transcriptome and Metabolome in Mice with Principal Cell-Specific Ablation of the Tsc1 Gene: Derangements in Pathways Associated with Cell Metabolism, Growth and Acid Secretion.
    Autorzy:
    Zahedi K; Department of Internal Medicine, Division of Nephrology, School of Medicine, University of New Mexico, Albuquerque, NM 87131, USA.; Research Services, New Mexico Veterans Health Care Center, Albuquerque, NM 87108, USA.
    Barone S; Department of Internal Medicine, Division of Nephrology, School of Medicine, University of New Mexico, Albuquerque, NM 87131, USA.; Research Services, New Mexico Veterans Health Care Center, Albuquerque, NM 87108, USA.
    Brooks M; Department of Internal Medicine, Division of Nephrology, School of Medicine, University of New Mexico, Albuquerque, NM 87131, USA.; Research Services, New Mexico Veterans Health Care Center, Albuquerque, NM 87108, USA.
    Murray Stewart T; The Sidney Kimmel Comprehensive Cancer Center, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.
    Casero RA Jr; The Sidney Kimmel Comprehensive Cancer Center, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.
    Soleimani M; Department of Internal Medicine, Division of Nephrology, School of Medicine, University of New Mexico, Albuquerque, NM 87131, USA.; Research Services, New Mexico Veterans Health Care Center, Albuquerque, NM 87108, USA.
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    Źródło:
    International journal of molecular sciences [Int J Mol Sci] 2022 Sep 13; Vol. 23 (18). Date of Electronic Publication: 2022 Sep 13.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Tuberous Sclerosis*/metabolism
    Tumor Suppressor Proteins*/genetics
    Humans ; Creatine/metabolism ; Galactose/metabolism ; GTP Phosphohydrolases/genetics ; Guanosine Triphosphate/metabolism ; Inosine/metabolism ; Inositol/metabolism ; Kidney/metabolism ; Metabolome ; NAD/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Transcriptome ; Tuberous Sclerosis Complex 1 Protein/genetics ; Tuberous Sclerosis Complex 1 Protein/metabolism ; Tuberous Sclerosis Complex 2 Protein/genetics ; Tuberous Sclerosis Complex 2 Protein/metabolism ; Uridine Diphosphate/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Expanded Potential of the Polyamine Analogue SBP-101 (Diethyl Dihydroxyhomospermine) as a Modulator of Polyamine Metabolism and Cancer Therapeutic.
    Autorzy:
    Holbert CE; Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21231, USA.
    Foley JR; Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21231, USA.
    Murray Stewart T; Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21231, USA.
    Casero RA Jr; Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21231, USA.
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    Źródło:
    International journal of molecular sciences [Int J Mol Sci] 2022 Jun 18; Vol. 23 (12). Date of Electronic Publication: 2022 Jun 18.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Antineoplastic Agents*/pharmacology
    Antineoplastic Agents*/therapeutic use
    Neoplasms*/drug therapy
    Animals ; Mice ; Ornithine Decarboxylase/metabolism ; Polyamines/metabolism ; Spermine/metabolism
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Self-Assembled Alkylated Polyamine Analogs as Supramolecular Anticancer Agents.
    Autorzy:
    Sil D; Department of Pharmaceutical Sciences, Center for Drug Delivery and Nanomedicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.
    Panja S; Department of Pharmaceutical Sciences, Center for Drug Delivery and Nanomedicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.
    Jogdeo CM; Department of Pharmaceutical Sciences, Center for Drug Delivery and Nanomedicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.
    Kumar R; Department of Pharmaceutical Sciences, Center for Drug Delivery and Nanomedicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.
    Yu A; Department of Pharmaceutical Sciences, Center for Drug Delivery and Nanomedicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.
    Holbert CE; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA.
    Ding L; Department of Pharmaceutical Sciences, Center for Drug Delivery and Nanomedicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.
    Foley JR; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA.
    Stewart TM; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA.
    Casero RA Jr; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA.
    Oupický D; Department of Pharmaceutical Sciences, Center for Drug Delivery and Nanomedicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.
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    Źródło:
    Molecules (Basel, Switzerland) [Molecules] 2022 Apr 10; Vol. 27 (8). Date of Electronic Publication: 2022 Apr 10.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Antineoplastic Agents*/pharmacology
    Lung Neoplasms*
    Nanoparticles*
    Cell Line, Tumor ; Humans ; Polyamines/chemistry ; Spermine/pharmacology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Spermidine is not an independent factor regulating limb muscle mass in mice following androgen deprivation.
    Autorzy:
    Gordon BS; Department of Nutrition, Food and Exercise Science, Florida State University, Tallahassee, FL 32306, USA.; Institute of Sports Sciences and Medicine, Florida State University, Tallahassee, FL 32306, USA.
    Rossetti ML; Department of Nutrition, Food and Exercise Science, Florida State University, Tallahassee, FL 32306, USA.
    Casero RA Jr; Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
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    Źródło:
    Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme [Appl Physiol Nutr Metab] 2021 May; Vol. 46 (5), pp. 452-460. Date of Electronic Publication: 2020 Oct 30.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Androgens/*physiology
    Muscle, Skeletal/*metabolism
    Spermidine/*metabolism
    Animals ; Male ; Mice, Inbred C57BL ; Microarray Analysis ; Muscle Strength ; Muscle, Skeletal/anatomy & histology ; Orchiectomy ; Polyamines/blood ; Polyamines/metabolism ; Signal Transduction ; Spermidine/administration & dosage ; Spermidine/blood ; Mice
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Emerging Role for Linear and Circular Spermine Oxidase RNAs in Skeletal Muscle Physiopathology.
    Autorzy:
    Reinoso-Sánchez JF; Department of Science, 'Department of Excellence 2018-2022', University of Rome 'Roma Tre', 00146 Rome, Italy.
    Baroli G; Department of Science, 'Department of Excellence 2018-2022', University of Rome 'Roma Tre', 00146 Rome, Italy.
    Duranti G; Laboratory of Biochemistry and Molecular Biology-Department of Movement, Human and Health Sciences, University of Rome 'Foro Italico', 00135 Rome, Italy.
    Scaricamazza S; Department of Biology, University of Rome 'Tor Vergata', 00133 Rome, Italy.
    Sabatini S; Laboratory of Biochemistry and Molecular Biology-Department of Movement, Human and Health Sciences, University of Rome 'Foro Italico', 00135 Rome, Italy.
    Valle C; IRCCS Fondazione Santa Lucia, 00179 Rome, Italy.; National Research Council, Institute of Translational Pharmacology (IFT), 00133 Rome, Italy.
    Morlando M; Department of Pharmaceutical Sciences, 'Department of Excellence 2018-2022', University of Perugia, 06123 Perugia, Italy.
    Casero RA Jr; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21287, USA.
    Bozzoni I; Department of Biology and Biotechnology 'Charles Dar win', University of Rome 'La Sapienza', 00185 Rome, Italy.; Center for Life Nano , Istituto Italiano di Tecnologia, 00161 Rome, Italy.
    Mariottini P; Department of Science, 'Department of Excellence 2018-2022', University of Rome 'Roma Tre', 00146 Rome, Italy.
    Ceci R; Laboratory of Biochemistry and Molecular Biology-Department of Movement, Human and Health Sciences, University of Rome 'Foro Italico', 00135 Rome, Italy.
    Cervelli M; Department of Science, 'Department of Excellence 2018-2022', University of Rome 'Roma Tre', 00146 Rome, Italy.; IRCCS Fondazione Santa Lucia, 00179 Rome, Italy.
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    Źródło:
    International journal of molecular sciences [Int J Mol Sci] 2020 Nov 03; Vol. 21 (21). Date of Electronic Publication: 2020 Nov 03.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Muscle, Skeletal/*metabolism
    Muscular Atrophy/*genetics
    Oxidoreductases Acting on CH-NH Group Donors/*genetics
    RNA, Circular/*physiology
    RNA, Messenger/*physiology
    Amyotrophic Lateral Sclerosis/genetics ; Amyotrophic Lateral Sclerosis/metabolism ; Amyotrophic Lateral Sclerosis/pathology ; Animals ; Cell Differentiation/genetics ; Cells, Cultured ; Disease Models, Animal ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Muscle Fibers, Skeletal/pathology ; Muscle Fibers, Skeletal/physiology ; Muscle, Skeletal/pathology ; Muscular Atrophy/metabolism ; Muscular Atrophy/pathology ; Oxidoreductases Acting on CH-NH Group Donors/physiology ; RNA, Untranslated/physiology ; RNA-Binding Protein FUS/genetics ; Superoxide Dismutase-1/genetics ; Polyamine Oxidase
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Ablation of polyamine catabolic enzymes provokes Purkinje cell damage, neuroinflammation, and severe ataxia.
    Autorzy:
    Zahedi K; Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA. .; Research Services, Veterans Affairs Medical Center, Cincinnati, OH, 45220, USA. .; Department of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, 87131, USA. .; Research Services, Veterans Affairs Medical Center, Albuquerque, NM, 87108, USA. .; Department of Internal Medicine, Division of Nephrology, University of New Mexico College of Medicine, 915 Camino de Salud, Bldg. 289, IDTC 3315, Albuquerque, NM, 87113, USA. .; Present Address: Department of Internal Medicine, Division of Nephrology, University of New Mexico College of Medicine, Albuquerque, NM, 87131, USA. .
    Brooks M; Research Services, Veterans Affairs Medical Center, Cincinnati, OH, 45220, USA.; Department of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, 87131, USA.; Present Address: Department of Internal Medicine, Division of Nephrology, University of New Mexico College of Medicine, Albuquerque, NM, 87131, USA.
    Barone S; Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA.; Research Services, Veterans Affairs Medical Center, Cincinnati, OH, 45220, USA.; Department of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, 87131, USA.; Research Services, Veterans Affairs Medical Center, Albuquerque, NM, 87108, USA.; Present Address: Department of Internal Medicine, Division of Nephrology, University of New Mexico College of Medicine, Albuquerque, NM, 87131, USA.
    Rahmati N; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02129, USA.
    Murray Stewart T; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
    Dunworth M; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
    Destefano-Shields C; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
    Dasgupta N; The Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.
    Davidson S; Department of Anesthesiology and Pain Research Center, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA.
    Lindquist DM; Department of Radiology, University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.
    Fuller CE; Upstate Medical University Department of Pathology, Syracuse, NY, 13219, USA.
    Smith RD; Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA.
    Cleveland JL; Department of Tumor Biology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA.; Department of Cancer Biology, The Scripps Research Institute, Jupiter, FL, USA.
    Casero RA Jr; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
    Soleimani M; Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA. .; Research Services, Veterans Affairs Medical Center, Cincinnati, OH, 45220, USA. .; Department of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, 87131, USA. .; Research Services, Veterans Affairs Medical Center, Albuquerque, NM, 87108, USA. .; Department of Internal Medicine, Division of Nephrology, University of New Mexico College of Medicine, 915 Camino de Salud, Bldg. 289, IDTC 3315, Albuquerque, NM, 87113, USA. .; Present Address: Department of Internal Medicine, Division of Nephrology, University of New Mexico College of Medicine, Albuquerque, NM, 87131, USA. .
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    Źródło:
    Journal of neuroinflammation [J Neuroinflammation] 2020 Oct 14; Vol. 17 (1), pp. 301. Date of Electronic Publication: 2020 Oct 14.
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Acetyltransferases/*deficiency
    Ataxia/*enzymology
    Oxidoreductases Acting on CH-NH Group Donors/*deficiency
    Purkinje Cells/*enzymology
    Acetyltransferases/genetics ; Animals ; Apoptosis/physiology ; Ataxia/genetics ; Ataxia/pathology ; Cerebellum/enzymology ; Cerebellum/pathology ; Inflammation/enzymology ; Inflammation/genetics ; Inflammation/pathology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Oxidoreductases Acting on CH-NH Group Donors/genetics ; Purkinje Cells/pathology ; Polyamine Oxidase
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Curcumin mediates polyamine metabolism and sensitizes gastrointestinal cancer cells to antitumor polyamine-targeted therapies.
    Autorzy:
    Murray-Stewart T; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.
    Dunworth M; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.
    Lui Y; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.
    Giardiello FM; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.; Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.
    Woster PM; Department of Drug Discovery and Biomedical Sciences, College of Pharmacy, Medical University of South Carolina, Charleston, SC, United States of America.
    Casero RA Jr; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.
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    Źródło:
    PloS one [PLoS One] 2018 Aug 23; Vol. 13 (8), pp. e0202677. Date of Electronic Publication: 2018 Aug 23 (Print Publication: 2018).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Antineoplastic Agents/*pharmacology
    Biosynthetic Pathways/*drug effects
    Curcumin/*pharmacology
    Gastrointestinal Neoplasms/*metabolism
    Polyamines/*metabolism
    Spermine/*analogs & derivatives
    Acetyltransferases/metabolism ; Adenosylmethionine Decarboxylase/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Drug Synergism ; Eflornithine/pharmacology ; Gastrointestinal Neoplasms/drug therapy ; Gastrointestinal Neoplasms/genetics ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Ornithine Decarboxylase/metabolism ; Oxidoreductases Acting on CH-NH Group Donors/genetics ; Spermine/pharmacology ; Polyamine Oxidase
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
    Tytuł:
    Activation of endoplasmic reticulum stress response by enhanced polyamine catabolism is important in the mediation of cisplatin-induced acute kidney injury.
    Autorzy:
    Zahedi K; Departments of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, United States of America.; Center on Genetics of Transport, University of Cincinnati College of Medicine, Cincinnati, OH, United States of America.; Research Services, Veterans Affairs Medical Center, Cincinnati, OH, United States of America.
    Barone S; Departments of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, United States of America.; Center on Genetics of Transport, University of Cincinnati College of Medicine, Cincinnati, OH, United States of America.; Research Services, Veterans Affairs Medical Center, Cincinnati, OH, United States of America.
    Destefano-Shields C; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
    Brooks M; Center on Genetics of Transport, University of Cincinnati College of Medicine, Cincinnati, OH, United States of America.
    Murray-Stewart T; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
    Dunworth M; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
    Li W; Department of Tumor Biology, Moffitt Cancer Center and Research Institute, Tampa, FL, United States of America.; Department of Cancer Biology, The Scripps Research Institute, Jupiter, FL, United States of America.
    Doherty JR; Department of Cancer Biology, The Scripps Research Institute, Jupiter, FL, United States of America.
    Hall MA; Department of Cancer Biology, The Scripps Research Institute, Jupiter, FL, United States of America.
    Smith RD; Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, United States of America.
    Cleveland JL; Department of Cancer Biology, The Scripps Research Institute, Jupiter, FL, United States of America.; Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, United States of America.
    Casero RA Jr; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
    Soleimani M; Departments of Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, United States of America.; Center on Genetics of Transport, University of Cincinnati College of Medicine, Cincinnati, OH, United States of America.; Research Services, Veterans Affairs Medical Center, Cincinnati, OH, United States of America.
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    Źródło:
    PloS one [PLoS One] 2017 Sep 08; Vol. 12 (9), pp. e0184570. Date of Electronic Publication: 2017 Sep 08 (Print Publication: 2017).
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Endoplasmic Reticulum Stress*
    Acute Kidney Injury/*chemically induced
    Acute Kidney Injury/*metabolism
    Antineoplastic Agents/*adverse effects
    Cisplatin/*adverse effects
    Polyamines/*metabolism
    Acetyltransferases/metabolism ; Acute Kidney Injury/pathology ; Animals ; Apoptosis/drug effects ; Disease Models, Animal ; Endoplasmic Reticulum Chaperone BiP ; Kidney Function Tests ; Metabolic Networks and Pathways ; Mice ; Oxidoreductases Acting on CH-NH Group Donors/metabolism ; Severity of Illness Index ; Polyamine Oxidase
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Biochemical evaluation of the anticancer potential of the polyamine-based nanocarrier Nano11047.
    Autorzy:
    Murray-Stewart T; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, Maryland, United States of America.
    Ferrari E; Center for Drug Delivery and Nanomedicine, Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.
    Xie Y; Center for Drug Delivery and Nanomedicine, Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.
    Yu F; Center for Drug Delivery and Nanomedicine, Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.
    Marton LJ; Department of Laboratory Medicine, University of California, San Francisco, California, United States of America.
    Oupicky D; Center for Drug Delivery and Nanomedicine, Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska, United States of America.
    Casero RA Jr; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, Maryland, United States of America.
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    Źródło:
    PloS one [PLoS One] 2017 Apr 19; Vol. 12 (4), pp. e0175917. Date of Electronic Publication: 2017 Apr 19 (Print Publication: 2017).
    Typ publikacji:
    Journal Article
    MeSH Terms:
    Drug Carriers*
    Gene Expression Regulation, Neoplastic*
    Antineoplastic Agents/*pharmacology
    Ornithine Decarboxylase/*genetics
    Prodrugs/*pharmacology
    Spermine/*analogs & derivatives
    Acetyltransferases/genetics ; Acetyltransferases/metabolism ; Antineoplastic Agents/chemical synthesis ; Biotransformation ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Humans ; Hydrogen Peroxide/metabolism ; Nanostructures/chemistry ; Ornithine Decarboxylase/metabolism ; Oxidoreductases Acting on CH-NH Group Donors/genetics ; Oxidoreductases Acting on CH-NH Group Donors/metabolism ; Polyamines/antagonists & inhibitors ; Polyamines/metabolism ; Prodrugs/chemical synthesis ; Prodrugs/metabolism ; Respiratory Mucosa/drug effects ; Respiratory Mucosa/metabolism ; Respiratory Mucosa/pathology ; Spermine/chemical synthesis ; Spermine/metabolism ; Spermine/pharmacology ; Tumor Burden/drug effects ; Polyamine Oxidase
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Increased Helicobacter pylori-associated gastric cancer risk in the Andean region of Colombia is mediated by spermine oxidase.
    Autorzy:
    Chaturvedi R; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
    de Sablet T; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
    Asim M; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
    Piazuelo MB; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
    Barry DP; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
    Verriere TG; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
    Sierra JC; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
    Hardbower DM; 1] Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA [2] Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
    Delgado AG; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
    Schneider BG; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
    Israel DA; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
    Romero-Gallo J; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
    Nagy TA; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
    Morgan DR; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
    Murray-Stewart T; Sidney Kimmel Comprehensive Cancer Center, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Bravo LE; Department of Pathology, Universidad del Valle School of Medicine, Cali, Colombia.
    Peek RM Jr; 1] Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA [2] Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
    Fox JG; Division of Comparative Medicine, Massachusetts lnstitute of Technology, Cambridge, MA, USA.
    Woster PM; Department of Drug Discovery and Biomedical Sciences, Medical University of South Carolina, Charleston, SC, USA.
    Casero RA Jr; Sidney Kimmel Comprehensive Cancer Center, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
    Correa P; Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
    Wilson KT; 1] Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA [2] Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA [3] Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN, USA [4] Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN, USA.
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    Źródło:
    Oncogene [Oncogene] 2015 Jun; Vol. 34 (26), pp. 3429-40. Date of Electronic Publication: 2014 Sep 01.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Adenocarcinoma*/epidemiology
    Adenocarcinoma*/genetics
    Adenocarcinoma*/microbiology
    Stomach Neoplasms*/epidemiology
    Stomach Neoplasms*/genetics
    Stomach Neoplasms*/microbiology
    Helicobacter Infections/*complications
    Helicobacter pylori/*physiology
    Oxidoreductases Acting on CH-NH Group Donors/*physiology
    Adult ; Animals ; Cells, Cultured ; Colombia/epidemiology ; DNA Damage/genetics ; Enzyme Induction ; Gerbillinae ; Helicobacter Infections/genetics ; Humans ; Hydrogen Peroxide/metabolism ; Male ; Middle Aged ; Oxidative Stress/genetics ; Risk Factors ; Polyamine Oxidase
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Proximal tubule epithelial cell specific ablation of the spermidine/spermine N1-acetyltransferase gene reduces the severity of renal ischemia/reperfusion injury.
    Autorzy:
    Zahedi K; Division of Nephrology and Hypertension, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America; Veterans Affair Medical Center, Cincinnati, Ohio, United States of America.
    Barone S; Division of Nephrology and Hypertension, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America; Veterans Affair Medical Center, Cincinnati, Ohio, United States of America.
    Wang Y; Division of Nephrology and Hypertension, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.
    Murray-Stewart T; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
    Roy-Chaudhury P; Division of Nephrology and Hypertension, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.
    Smith RD; Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America.
    Casero RA Jr; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America.
    Soleimani M; Division of Nephrology and Hypertension, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America; Veterans Affair Medical Center, Cincinnati, Ohio, United States of America.
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    Źródło:
    PloS one [PLoS One] 2014 Nov 12; Vol. 9 (11), pp. e110161. Date of Electronic Publication: 2014 Nov 12 (Print Publication: 2014).
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Acetyltransferases/*genetics
    Epithelial Cells/*metabolism
    Kidney/*pathology
    Kidney Tubules, Proximal/*cytology
    Reperfusion Injury/*pathology
    Animals ; Cytokines/biosynthesis ; Genotype ; HEK293 Cells ; Humans ; Immunity, Innate ; Inflammation ; Male ; Mice ; Mice, Knockout ; Neutrophils/metabolism ; Oxidoreductases Acting on CH-NH Group Donors/chemistry ; Polyamines/chemistry ; Polyamine Oxidase
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia.
    Autorzy:
    Schenk T; Division of Molecular Pathology, Institute of Cancer Research, Sutton, UK.
    Chen WC
    Göllner S
    Howell L
    Jin L
    Hebestreit K
    Klein HU
    Popescu AC
    Burnett A
    Mills K
    Casero RA Jr
    Marton L
    Woster P
    Minden MD
    Dugas M
    Wang JC
    Dick JE
    Müller-Tidow C
    Petrie K
    Zelent A
    Pokaż więcej
    Źródło:
    Nature medicine [Nat Med] 2012 Mar 11; Vol. 18 (4), pp. 605-11. Date of Electronic Publication: 2012 Mar 11.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Cell Differentiation/*drug effects
    Leukemia, Myeloid, Acute/*drug therapy
    Leukemia, Myeloid, Acute/*pathology
    Tretinoin/*therapeutic use
    Animals ; Antigens, CD34/metabolism ; Apoptosis/drug effects ; Apoptosis/physiology ; CD11b Antigen/metabolism ; Cells, Cultured ; Cytokines/metabolism ; Disease Models, Animal ; Drug Interactions ; Enzyme Inhibitors/therapeutic use ; Female ; Flow Cytometry ; Gene Expression Regulation/drug effects ; Histone Demethylases/metabolism ; Humans ; Lysine/metabolism ; Mice ; Mice, Inbred NOD ; Mice, SCID ; RNA, Small Interfering/metabolism ; Stem Cell Factor/metabolism ; Time Factors ; Transplants ; Tranylcypromine/therapeutic use ; Tretinoin/pharmacology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    L-arginine supplementation improves responses to injury and inflammation in dextran sulfate sodium colitis.
    Autorzy:
    Coburn LA; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.
    Gong X
    Singh K
    Asim M
    Scull BP
    Allaman MM
    Williams CS
    Rosen MJ
    Washington MK
    Barry DP
    Piazuelo MB
    Casero RA Jr
    Chaturvedi R
    Zhao Z
    Wilson KT
    Pokaż więcej
    Źródło:
    PloS one [PLoS One] 2012; Vol. 7 (3), pp. e33546. Date of Electronic Publication: 2012 Mar 12.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Arginine/*pharmacokinetics
    Arginine/*pharmacology
    Colitis, Ulcerative/*chemically induced
    Colitis, Ulcerative/*drug therapy
    Dextran Sulfate/*toxicity
    Gene Expression Regulation/*drug effects
    Amino Acids/blood ; Amino Acids/metabolism ; Animals ; Arginine/therapeutic use ; Blotting, Western ; Cationic Amino Acid Transporter 2/metabolism ; Cell Movement/drug effects ; Chemokines/metabolism ; Colitis, Ulcerative/pathology ; Cytokines/metabolism ; DNA Primers/genetics ; Dietary Supplements ; Epithelial Cells/drug effects ; Gene Expression Regulation/physiology ; Immunohistochemistry ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Microarray Analysis ; Neutrophils/drug effects ; Nitric Oxide Synthase Type II/genetics ; Organ Size/drug effects ; Permeability/drug effects ; Weight Loss/drug effects
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Difluoromethylornithine is a novel inhibitor of Helicobacter pylori growth, CagA translocation, and interleukin-8 induction.
    Autorzy:
    Barry DP; Division of Gastroenterology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America.
    Asim M
    Leiman DA
    de Sablet T
    Singh K
    Casero RA Jr
    Chaturvedi R
    Wilson KT
    Pokaż więcej
    Źródło:
    PloS one [PLoS One] 2011 Feb 28; Vol. 6 (2), pp. e17510. Date of Electronic Publication: 2011 Feb 28.
    Typ publikacji:
    Evaluation Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
    MeSH Terms:
    Antigens, Bacterial/*metabolism
    Bacterial Proteins/*metabolism
    Eflornithine/*pharmacology
    Helicobacter Infections/*microbiology
    Helicobacter pylori/*drug effects
    Helicobacter pylori/*growth & development
    Interleukin-8/*genetics
    Animals ; Bacterial Proteins/antagonists & inhibitors ; Cells, Cultured ; Eflornithine/therapeutic use ; Enzyme Inhibitors/pharmacology ; Enzyme Inhibitors/therapeutic use ; Gastric Mucosa/metabolism ; Gastric Mucosa/microbiology ; Gastric Mucosa/pathology ; Gastritis/microbiology ; Gastritis/prevention & control ; Helicobacter Infections/genetics ; Helicobacter Infections/metabolism ; Helicobacter Infections/prevention & control ; Helicobacter pylori/physiology ; Humans ; Interleukin-8/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Protein Transport/drug effects ; Transcriptional Activation/drug effects
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Spermine oxidase (SMO) activity in breast tumor tissues and biochemical analysis of the anticancer spermine analogues BENSpm and CPENSpm.
    Autorzy:
    Cervelli M; Dipartimento di Biologia, Università Roma Tre, Rome, Italy.
    Bellavia G
    Fratini E
    Amendola R
    Polticelli F
    Barba M
    Federico R
    Signore F
    Gucciardo G
    Grillo R
    Woster PM
    Casero RA Jr
    Mariottini P
    Pokaż więcej
    Źródło:
    BMC cancer [BMC Cancer] 2010 Oct 14; Vol. 10, pp. 555. Date of Electronic Publication: 2010 Oct 14.
    Typ publikacji:
    Journal Article; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Gene Expression Regulation, Enzymologic*
    Gene Expression Regulation, Neoplastic*
    Antineoplastic Agents/*pharmacology
    Breast Neoplasms/*metabolism
    Oxidoreductases Acting on CH-NH Group Donors/*metabolism
    Polyamines/*pharmacology
    Spermine/*analogs & derivatives
    Aged ; Aged, 80 and over ; Animals ; Female ; Gene Expression Profiling ; Humans ; Mice ; Middle Aged ; Recombinant Proteins/chemistry ; Spermine/pharmacology ; Polyamine Oxidase
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Nuclear localization of human spermine oxidase isoforms - possible implications in drug response and disease etiology.
    Autorzy:
    Murray-Stewart T; Department of Oncology, Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA.
    Wang Y
    Goodwin A
    Hacker A
    Meeker A
    Casero RA Jr
    Pokaż więcej
    Źródło:
    The FEBS journal [FEBS J] 2008 Jun; Vol. 275 (11), pp. 2795-806. Date of Electronic Publication: 2008 Apr 17.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
    MeSH Terms:
    Cell Nucleus/*metabolism
    Oxidoreductases Acting on CH-NH Group Donors/*chemistry
    Alternative Splicing ; Cell Line, Tumor ; Chemistry, Pharmaceutical/methods ; DNA Damage ; Drug Design ; Humans ; Hydrogen Peroxide/chemistry ; Models, Chemical ; Models, Genetic ; Polyamines/chemistry ; Protein Isoforms ; Reactive Oxygen Species ; Substrate Specificity ; Polyamine Oxidase
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases.
    Autorzy:
    Casero RA Jr; The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, USA. />Marton LJ
    Pokaż więcej
    Źródło:
    Nature reviews. Drug discovery [Nat Rev Drug Discov] 2007 May; Vol. 6 (5), pp. 373-90.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
    MeSH Terms:
    Antineoplastic Agents/*pharmacology
    Biogenic Polyamines/*metabolism
    Neoplasms/*metabolism
    Animals ; Antineoplastic Agents/therapeutic use ; Biogenic Polyamines/antagonists & inhibitors ; Biogenic Polyamines/biosynthesis ; Enzyme Inhibitors/pharmacology ; Enzyme Inhibitors/therapeutic use ; Humans ; Neoplasms/drug therapy ; Neoplasms/enzymology
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
    Tytuł:
    Mammalian polyamine catabolism: a therapeutic target, a pathological problem, or both?
    Autorzy:
    Wang Y; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, Maryland, 21231, USA.
    Casero RA Jr
    Pokaż więcej
    Źródło:
    Journal of biochemistry [J Biochem] 2006 Jan; Vol. 139 (1), pp. 17-25.
    Typ publikacji:
    Journal Article; Research Support, N.I.H., Extramural; Review
    MeSH Terms:
    Biogenic Polyamines/*metabolism
    Acetyltransferases/genetics ; Acetyltransferases/metabolism ; Animals ; Cloning, Molecular ; Humans ; Mammals ; Mice ; Mice, Transgenic ; Reactive Oxygen Species/metabolism ; Substrate Specificity ; Transcription, Genetic
    Czasopismo naukowe
    Pełny tekst  Link otwiera się w nowym oknieSzczegóły
      Wyświetlanie 1-19 z 19

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