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Wyszukujesz frazę ""Caspase 3"" wg kryterium: Temat


Tytuł :
Pregabalin induced reproductive toxicity and body weight changes by affecting caspase3 and leptin expression: Protective role of wheat germ oil.
Autorzy :
Shokry DA; Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Cairo University, Egypt.
El Nabrawy N; National Research Center, Faculty of Medicine, Cairo University, Egypt.
Yassa HD; Anatomy and Embryology Department, Faculty of Medicine, Beni-Suef University, Egypt.
Gaber SS; Biochemistry Department, Faculty of Medicine, Minia University, Egypt.
Batiha GE; Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Egypt.
Welson NN; Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Beni-Suef University, Egypt. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2020 Nov 01; Vol. 260, pp. 118344. Date of Electronic Publication: 2020 Aug 24.
Typ publikacji :
Journal Article
MeSH Terms :
Body Weight/*drug effects
Caspase 3/*metabolism
Leptin/*metabolism
Oxidative Stress/*drug effects
Plant Oils/*pharmacology
Pregabalin/*toxicity
Reproduction/*drug effects
Animals ; Caspase 3/genetics ; Female ; Leptin/genetics ; Plant Oils/administration & dosage ; Protective Agents/administration & dosage ; Protective Agents/pharmacology ; Rats
Czasopismo naukowe
Tytuł :
Deep profiling of protease substrate specificity enabled by dual random and scanned human proteome substrate phage libraries.
Autorzy :
Zhou J; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158.
Li S; Department of Biomedical Data Science, Stanford University, Stanford, CA 94305.
Leung KK; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158.
O'Donovan B; Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158.
Zou JY; Department of Biomedical Data Science, Stanford University, Stanford, CA 94305.; Chan Zuckerberg Biohub, San Francisco, CA 94158.
DeRisi JL; Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158.; Chan Zuckerberg Biohub, San Francisco, CA 94158.
Wells JA; Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158; .; Chan Zuckerberg Biohub, San Francisco, CA 94158.; Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158.
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Oct 13; Vol. 117 (41), pp. 25464-25475. Date of Electronic Publication: 2020 Sep 24.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Proteome*
Caspase 3/*metabolism
Caspase 3/genetics ; Gene Expression Regulation, Enzymologic ; Humans ; Peptide Library ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Effective inhibition of cancer cells by recombinant adenovirus expressing EGFR-targeting artificial microRNA and reversed-caspase-3.
Autorzy :
Yan M; Department of Otorhinolaryngology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People's Republic of China.
Chen J; Department of Otorhinolaryngology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People's Republic of China.
Jiang H; Department of Otorhinolaryngology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People's Republic of China.
Xie Y; Clinical Research Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People's Republic of China.
Li C; Clinical Research Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People's Republic of China.
Chen L; Clinical Research Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People's Republic of China.
Yang B; Department of Otorhinolaryngology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People's Republic of China.
Cao J; Clinical Research Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People's Republic of China.
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Źródło :
PloS one [PLoS One] 2020 Aug 03; Vol. 15 (8), pp. e0237098. Date of Electronic Publication: 2020 Aug 03 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Caspase 3/*metabolism
ErbB Receptors/*genetics
MicroRNAs/*genetics
Neoplasms, Experimental/*therapy
RNAi Therapeutics/*methods
Adenoviridae/genetics ; Animals ; Antineoplastic Combined Chemotherapy Protocols ; Apoptosis ; Caspase 3/genetics ; Cell Line, Tumor ; Cell Proliferation ; Cetuximab/administration & dosage ; Cetuximab/therapeutic use ; Cisplatin/administration & dosage ; Cisplatin/therapeutic use ; ErbB Receptors/metabolism ; HEK293 Cells ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; MicroRNAs/metabolism ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/metabolism ; Neoplasms, Experimental/drug therapy ; Proto-Oncogene Proteins c-akt/metabolism
Czasopismo naukowe
Tytuł :
Mechanistic perspective of protective effects of nilotinib against cisplatin-induced testicular injury in rats: Role of JNK/caspase-3 signaling inhibition.
Autorzy :
Saad KM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.
Abdelrahman RS; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Taibah University, Al Madinah Al-Munawwarah, Saudi Arabia.
Said E; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt. Electronic address: .
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Źródło :
Environmental toxicology and pharmacology [Environ Toxicol Pharmacol] 2020 May; Vol. 76, pp. 103334. Date of Electronic Publication: 2020 Feb 03.
Typ publikacji :
Journal Article
MeSH Terms :
Caspase 3/*metabolism
Cisplatin/*toxicity
MAP Kinase Kinase 4/*metabolism
Pyrimidines/*pharmacology
Signal Transduction/*drug effects
Testis/*drug effects
Animals ; Antineoplastic Agents/toxicity ; Antioxidants/metabolism ; Caspase 3/genetics ; Gene Expression Regulation/drug effects ; Ki-67 Antigen/genetics ; Ki-67 Antigen/metabolism ; MAP Kinase Kinase 4/genetics ; Male ; Oxidants/metabolism ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Immune-associated renal disease found in caspase 3-deficient mice.
Autorzy :
Suzuki T; Laboratory of Anatomy, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-ku, Sapporo, 060-0818, Japan.
Ichii O; Laboratory of Anatomy, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-ku, Sapporo, 060-0818, Japan. .
Nakamura T; Laboratory of Anatomy, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-ku, Sapporo, 060-0818, Japan.; Section of Biological Safety Research, Chitose Laboratory, Japan Food Research Laboratories, Chitose, Japan.
Horino T; Department of Endocrinology, Metabolism and Nephrology, Kochi Medical School, Kochi University, Nankoku, Japan.
Elewa YHA; Laboratory of Anatomy, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-ku, Sapporo, 060-0818, Japan.; Department of Histology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.
Kon Y; Laboratory of Anatomy, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-ku, Sapporo, 060-0818, Japan.
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Źródło :
Cell and tissue research [Cell Tissue Res] 2020 Feb; Vol. 379 (2), pp. 323-335. Date of Electronic Publication: 2019 Aug 22.
Typ publikacji :
Journal Article
MeSH Terms :
Caspase 3/*deficiency
Kidney Diseases/*enzymology
Kidney Diseases/*immunology
Animals ; Caspase 3/genetics ; Caspase 3/metabolism ; Female ; Gene Ontology ; Immunity ; Kidney Glomerulus/enzymology ; Kidney Glomerulus/pathology ; Kidney Glomerulus/ultrastructure ; Mice, Inbred C57BL ; Mice, Knockout ; Organ Specificity
Czasopismo naukowe
Tytuł :
Conserved function of Pacific cod Caspase-3 in apoptosis.
Autorzy :
Gu J; Key Laboratory of Mariculture & Stock Enhancement in North China's Sea, Ministry of Agriculture and Rural Affairs, Key Laboratory of Fish Applied Biology and Aquaculture in North China, Liaoning Province, College of Fisheries and Life Sciences, Dalian Ocean University, Dalian 116023, China.
Zhan AJ; Shenzhen Academy of Inspection and Quarantine, Shenzhen 518000, China.
Jiang JL; Key Laboratory of Mariculture & Stock Enhancement in North China's Sea, Ministry of Agriculture and Rural Affairs, Key Laboratory of Fish Applied Biology and Aquaculture in North China, Liaoning Province, College of Fisheries and Life Sciences, Dalian Ocean University, Dalian 116023, China.
Chen Y; Key Laboratory of Mariculture & Stock Enhancement in North China's Sea, Ministry of Agriculture and Rural Affairs, Key Laboratory of Fish Applied Biology and Aquaculture in North China, Liaoning Province, College of Fisheries and Life Sciences, Dalian Ocean University, Dalian 116023, China.
Xu J; Key Laboratory of Mariculture & Stock Enhancement in North China's Sea, Ministry of Agriculture and Rural Affairs, Key Laboratory of Fish Applied Biology and Aquaculture in North China, Liaoning Province, College of Fisheries and Life Sciences, Dalian Ocean University, Dalian 116023, China.
Ye L; Key Laboratory of Mariculture & Stock Enhancement in North China's Sea, Ministry of Agriculture and Rural Affairs, Key Laboratory of Fish Applied Biology and Aquaculture in North China, Liaoning Province, College of Fisheries and Life Sciences, Dalian Ocean University, Dalian 116023, China.
Mao MG; Key Laboratory of Mariculture & Stock Enhancement in North China's Sea, Ministry of Agriculture and Rural Affairs, Key Laboratory of Fish Applied Biology and Aquaculture in North China, Liaoning Province, College of Fisheries and Life Sciences, Dalian Ocean University, Dalian 116023, China. Electronic address: .
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Źródło :
Gene [Gene] 2020 Mar 30; Vol. 732, pp. 144370. Date of Electronic Publication: 2020 Jan 16.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*physiology
Caspase 3/*physiology
Fish Proteins/*physiology
Amino Acid Sequence ; Animals ; Caspase 3/chemistry ; Caspase 3/genetics ; Fish Proteins/chemistry ; Fish Proteins/genetics ; Gadiformes ; Phylogeny ; Sequence Alignment ; Subcellular Fractions/metabolism
Czasopismo naukowe
Tytuł :
Apoptotic and predictive factors by Bax, Caspases 3/9, Bcl-2, p53 and Ki-67 in prostate cancer after 12 Gy single-dose.
Autorzy :
Pisani C; Department of Translational Medicine, University of Piemonte Orientale (UPO), via Solaroli 17, 28100, Novara, Italy. .; Division of Radiation Oncology, University Hospital 'Maggiore della Carità', corso Mazzini 18, 28100, Novara, Italy. .
Ramella M; Department of Health Science, University of Piemonte Orientale (UPO), via Solaroli 17, 28100, Novara, Italy.
Boldorini R; Department of Health Science, University of Piemonte Orientale (UPO), via Solaroli 17, 28100, Novara, Italy.; Division of Pathology, University of Piemonte Orientale (UPO), via Solaroli 17, 28100, Novara, Italy.
Loi G; Medical Physics, University Hospital 'Maggiore della Carità', corso Mazzini 18, 28100, Novara, Italy.
Billia M; Division of Urology, University Hospital 'Maggiore della Carità', corso Mazzini 18, 28100, Novara, Italy.
Boccafoschi F; Department of Health Science, University of Piemonte Orientale (UPO), via Solaroli 17, 28100, Novara, Italy.
Volpe A; Department of Translational Medicine, University of Piemonte Orientale (UPO), via Solaroli 17, 28100, Novara, Italy.; Division of Urology, University Hospital 'Maggiore della Carità', corso Mazzini 18, 28100, Novara, Italy.
Krengli M; Department of Translational Medicine, University of Piemonte Orientale (UPO), via Solaroli 17, 28100, Novara, Italy. .; Division of Radiation Oncology, University Hospital 'Maggiore della Carità', corso Mazzini 18, 28100, Novara, Italy. .
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Źródło :
Scientific reports [Sci Rep] 2020 Apr 27; Vol. 10 (1), pp. 7050. Date of Electronic Publication: 2020 Apr 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*physiology
Caspase 3/*metabolism
Caspase 9/*metabolism
Ki-67 Antigen/*metabolism
Proto-Oncogene Proteins c-bcl-2/*metabolism
Tumor Suppressor Protein p53/*metabolism
bcl-2-Associated X Protein/*metabolism
Aged ; Apoptosis/genetics ; Caspase 3/genetics ; Caspase 9/genetics ; Humans ; Immunohistochemistry ; Ki-67 Antigen/genetics ; Male ; Middle Aged ; Proto-Oncogene Proteins c-bcl-2/genetics ; Tumor Suppressor Protein p53/genetics ; bcl-2-Associated X Protein/genetics
Czasopismo naukowe
Tytuł :
Cellular Caspase-3 Contributes to EV-A71 2A -Mediated Down-Regulation of IFNAR1 at the Translation Level.
Autorzy :
Chen B; Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100083, China.
Wang Y; Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100083, China.
Pei X; Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100083, China.
Wang S; Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100083, China.
Zhang H; Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100083, China.
Peng Y; Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, 100083, China. .
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Źródło :
Virologica Sinica [Virol Sin] 2020 Feb; Vol. 35 (1), pp. 64-72. Date of Electronic Publication: 2019 Sep 11.
Typ publikacji :
Journal Article
MeSH Terms :
Down-Regulation*
Host-Pathogen Interactions*/genetics
Host-Pathogen Interactions*/immunology
Protein Biosynthesis*
Caspase 3/*genetics
Enterovirus A, Human/*immunology
Receptor, Interferon alpha-beta/*genetics
Caspase 3/immunology ; Cell Line, Tumor ; Gene Expression Regulation/immunology ; Humans ; Receptor, Interferon alpha-beta/immunology ; Rhabdomyosarcoma ; Signal Transduction
Czasopismo naukowe
Tytuł :
Stem-like cells of various origins showed therapeutic effect to improve the recovery of spinal cord injury.
Autorzy :
Kang J; Department of Orthopedics, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, China.
Zhang C; Department of Orthopedics, School of Medicine, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, China.
Zhi Z; Department of Orthopedics, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, China.
Wang Y; Department of Orthopedics, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, China.
Liu J; Department of Orthopedics, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, China.
Wu F; Shanghai Clinical Research Center for Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
Xu G; Department of Orthopedics, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, China.
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Źródło :
Artificial cells, nanomedicine, and biotechnology [Artif Cells Nanomed Biotechnol] 2020 Dec; Vol. 48 (1), pp. 627-638.
Typ publikacji :
Journal Article
MeSH Terms :
Exosomes/*transplantation
MicroRNAs/*genetics
Spinal Cord Injuries/*therapy
Stem Cells/*metabolism
Animals ; Apoptosis/drug effects ; Apoptosis/genetics ; Caspase 3/genetics ; Caspase 3/metabolism ; Cells, Cultured ; Culture Media, Conditioned/metabolism ; Culture Media, Conditioned/pharmacology ; Exosomes/genetics ; Exosomes/metabolism ; Gene Expression Regulation ; Humans ; Locomotion/physiology ; Male ; Neuroepithelial Cells/cytology ; Neuroepithelial Cells/metabolism ; Neurons/metabolism ; Neurons/pathology ; PTEN Phosphohydrolase/genetics ; PTEN Phosphohydrolase/metabolism ; Rats ; Rats, Sprague-Dawley ; Signal Transduction ; Spinal Cord Injuries/pathology ; Spinal Cord Injuries/physiopathology ; Stem Cells/cytology
Czasopismo naukowe
Tytuł :
AMP-activated protein kinase contributes to cisplatin-induced renal epithelial cell apoptosis and acute kidney injury.
Autorzy :
Jin X; Section of Nephrology, Department of Medicine, Baylor College of Medicine, Houston, Texas.; Department of Anesthesiology, The Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, China.
An C; Section of Nephrology, Department of Medicine, Baylor College of Medicine, Houston, Texas.; Division of Nephrology, Department of Medicine, University of Connecticut School of Medicine, Farmington, Connecticut.
Jiao B; Division of Nephrology, Department of Medicine, University of Connecticut School of Medicine, Farmington, Connecticut.
Safirstein RL; Renal Section, Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut.
Wang Y; Section of Nephrology, Department of Medicine, Baylor College of Medicine, Houston, Texas.; Division of Nephrology, Department of Medicine, University of Connecticut School of Medicine, Farmington, Connecticut.; Renal Section, Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut.; Department of Cell Biology, University of Connecticut School of Medicine, Farmington, Connecticut.; Institute for Systems Genomics, University of Connecticut School of Medicine, Farmington, Connecticut.
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Źródło :
American journal of physiology. Renal physiology [Am J Physiol Renal Physiol] 2020 Dec 01; Vol. 319 (6), pp. F1073-F1080. Date of Electronic Publication: 2020 Oct 26.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
AMP-Activated Protein Kinases/*metabolism
Acute Kidney Injury/*chemically induced
Apoptosis/*drug effects
Cisplatin/*toxicity
Epithelial Cells/*drug effects
Kidney Tubules/*drug effects
AMP-Activated Protein Kinases/genetics ; Acute Kidney Injury/enzymology ; Acute Kidney Injury/pathology ; Animals ; Caspase 3/metabolism ; Cell Line ; Epithelial Cells/enzymology ; Epithelial Cells/pathology ; Kidney Tubules/enzymology ; Kidney Tubules/pathology ; Mice ; Phosphorylation ; Signal Transduction ; Tumor Suppressor Protein p53/metabolism ; bcl-2-Associated X Protein/metabolism
Czasopismo naukowe
Tytuł :
Role of Bm30kc6 gene in cell apoptosis and the silk gland degradation signaling pathway in Bombyx mori L.
Autorzy :
Xiao Y; College of Animal Sciences, Zhejiang University, Hangzhou, China.
Li LL; College of Animal Sciences, Zhejiang University, Hangzhou, China.
Bibi A; College of Animal Sciences, Zhejiang University, Hangzhou, China.
Zhang N; Zhejiang Agriculture & Forestry University, Hangzhou, China.
Chen T; College of Animal Sciences, Zhejiang University, Hangzhou, China.
Mo Y; College of Animal Sciences, Zhejiang University, Hangzhou, China.
Yue W; Zhejiang Agriculture & Forestry University, Hangzhou, China.
Miao Y; College of Animal Sciences, Zhejiang University, Hangzhou, China.
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Źródło :
Archives of insect biochemistry and physiology [Arch Insect Biochem Physiol] 2020 Nov; Vol. 105 (3), pp. e21741. Date of Electronic Publication: 2020 Oct 01.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*genetics
Bombyx/*genetics
Bombyx/*growth & development
Animals ; Bombyx/metabolism ; Caspase 3/genetics ; Caspase 3/metabolism ; Caspase Inhibitors/pharmacology ; Dactinomycin/pharmacology ; Ecdysone/pharmacology ; Gene Expression Regulation, Developmental ; Hemolymph/metabolism ; Insect Proteins/genetics ; Insect Proteins/metabolism ; RNA, Small Interfering ; Signal Transduction ; Ultraviolet Rays
Czasopismo naukowe
Tytuł :
Piperine sensitizes radiation-resistant cancer cells towards radiation and promotes intrinsic pathway of apoptosis.
Autorzy :
Shaheer K; Molecular Biology Division, Yenepoya Research Centre, Yenepoya (deemed to be University), Deralakatte, Mangalore, Karnataka, 575018, India.
Somashekarappa HM; Centre for Application of Radioisotopes and Radiation Technology (CARRT), USIC, Mangalore University, Mangalore, Karnataka, 575018, India.
Lakshmanan MD; Molecular Biology Division, Yenepoya Research Centre, Yenepoya (deemed to be University), Deralakatte, Mangalore, Karnataka, 575018, India.
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Źródło :
Journal of food science [J Food Sci] 2020 Nov; Vol. 85 (11), pp. 4070-4079. Date of Electronic Publication: 2020 Oct 21.
Typ publikacji :
Journal Article
MeSH Terms :
Alkaloids/*pharmacology
Apoptosis/*drug effects
Apoptosis/*radiation effects
Benzodioxoles/*pharmacology
Neoplasms/*physiopathology
Piperidines/*pharmacology
Polyunsaturated Alkamides/*pharmacology
Caspase 3/genetics ; Caspase 3/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/radiation effects ; HT29 Cells ; Humans ; Mitochondria/drug effects ; Mitochondria/metabolism ; Mitochondria/radiation effects ; Neoplasms/genetics ; Neoplasms/metabolism ; Poly (ADP-Ribose) Polymerase-1/genetics ; Poly (ADP-Ribose) Polymerase-1/metabolism ; Radiation ; Signal Transduction/drug effects ; Signal Transduction/radiation effects
Czasopismo naukowe
Tytuł :
One-Pot Radiosynthesis and Biological Evaluation of a Caspase-3 Selective 5-[ I]iodo-1,2,3-triazole derived Isatin SPECT Tracer.
Autorzy :
Glaser M; Centre for Radiopharmaceutical Chemistry, University College London, 5 Gower Place, London, WC1E 6BS, United Kingdom.; Department of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ, United Kingdom.
Rajkumar V; UCL, Cancer Institute, 72 Huntley Street, London, WC1E 6DD, UK.
Diocou S; UCL, Cancer Institute, 72 Huntley Street, London, WC1E 6DD, UK.
Gendron T; Centre for Radiopharmaceutical Chemistry, University College London, 5 Gower Place, London, WC1E 6BS, United Kingdom.; Department of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ, United Kingdom.
Yan R; King's College London, School of Biomedical Engineering and Imaging Sciences, St. Thomas' Hospital, SE1 7EH, London, United Kingdom.
Sin PKB; Centre for Radiopharmaceutical Chemistry, University College London, 5 Gower Place, London, WC1E 6BS, United Kingdom.
Sander K; Centre for Radiopharmaceutical Chemistry, University College London, 5 Gower Place, London, WC1E 6BS, United Kingdom.; Department of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ, United Kingdom.
Carroll L; Imperial College London, Science, Technology & Medicine, Department of Medicine, Hammersmith Hospital, DuCane Road, London, W12 0NN, United Kingdom.
Pedley RB; UCL, Cancer Institute, 72 Huntley Street, London, WC1E 6DD, UK.
Aboagye EO; Imperial College London, Science, Technology & Medicine, Department of Medicine, Hammersmith Hospital, DuCane Road, London, W12 0NN, United Kingdom.
Witney TH; King's College London, School of Biomedical Engineering and Imaging Sciences, St. Thomas' Hospital, SE1 7EH, London, United Kingdom.; Centre for Advanced Biomedical Imaging, Division of Medicine, University College London, London, United Kingdom.
Årstad E; Centre for Radiopharmaceutical Chemistry, University College London, 5 Gower Place, London, WC1E 6BS, United Kingdom. .; Department of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ, United Kingdom. .
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Źródło :
Scientific reports [Sci Rep] 2019 Dec 17; Vol. 9 (1), pp. 19299. Date of Electronic Publication: 2019 Dec 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis/*drug effects
Caspase 3/*isolation & purification
Iodine Radioisotopes/*pharmacology
Neoplasms/*diagnostic imaging
Animals ; Apoptosis/genetics ; Caspase 3/chemistry ; Caspase 3/genetics ; Cell Line, Tumor ; Copper/chemistry ; Fluorine Radioisotopes/chemistry ; Fluorine Radioisotopes/pharmacology ; Heterografts ; Humans ; Iodine Radioisotopes/chemistry ; Isatin/chemical synthesis ; Isatin/pharmacology ; Mice ; Neoplasms/pathology ; Neoplasms/therapy ; Radiopharmaceuticals/chemical synthesis ; Radiopharmaceuticals/pharmacology ; Tissue Distribution ; Tomography, Emission-Computed, Single-Photon/methods ; Triazoles/chemical synthesis ; Triazoles/pharmacology
Czasopismo naukowe
Tytuł :
Caspase-3C gene from red swamp crayfish, Procambarus clarki: Characterization and expression in response to pathogenic infection.
Autorzy :
Chen YL; College of Food and Biological Engineering, Jimei University, Xiamen, Fujian Province, 361021, China.
Han K; College of Marine Science and Engineering, Nanjing Normal University, Nanjing, China.
Huang X; College of Marine Science and Engineering, Nanjing Normal University, Nanjing, China.
Zhang Z; College of Marine Science and Engineering, Nanjing Normal University, Nanjing, China.
Wan X; Institute of Oceanology and Marine Fisheries, Jiangsu, PR China. Electronic address: .
Ren Q; Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, Jinan, 250014, PR China; Co-Innovation Center for Marine Bio-Industry Technology of Jiangsu Province, Lianyungang, Jiangsu Province, 222005, China; College of Marine Science and Engineering, Nanjing Normal University, Nanjing, China. Electronic address: .
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Źródło :
Fish & shellfish immunology [Fish Shellfish Immunol] 2019 Nov; Vol. 94, pp. 792-799. Date of Electronic Publication: 2019 Oct 01.
Typ publikacji :
Journal Article
MeSH Terms :
Astacoidea/*genetics
Astacoidea/*immunology
Caspase 3/*genetics
Caspase 3/*immunology
Gene Expression Regulation/*immunology
Immunity, Innate/*genetics
Amino Acid Sequence ; Animals ; Arthropod Proteins/chemistry ; Arthropod Proteins/genetics ; Arthropod Proteins/immunology ; Base Sequence ; Caspase 3/chemistry ; Gene Expression Profiling ; Phylogeny ; Sequence Alignment
Czasopismo naukowe
Tytuł :
Inflammation-induced Occludin Downregulation Limits Epithelial Apoptosis by Suppressing Caspase-3 Expression.
Autorzy :
Kuo WT; Laboratory of Mucosal Barrier Pathobiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Shen L; Department of Pathology, The University of Chicago, Chicago, Illinois.
Zuo L; Laboratory of Mucosal Barrier Pathobiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Anhui Medical University, Hefei, Anhui, China.
Shashikanth N; Laboratory of Mucosal Barrier Pathobiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Ong MLDM; Laboratory of Mucosal Barrier Pathobiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Wu L; Department of Pathology, The University of Chicago, Chicago, Illinois.
Zha J; Department of Pathology, The University of Chicago, Chicago, Illinois; Soochow University and Department of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Edelblum KL; Department of Pathology, The University of Chicago, Chicago, Illinois; Department of Pathology and Laboratory Medicine, Center for Inflammation and Immunity, Rutgers New Jersey Medical School, Newark, New Jersey.
Wang Y; Department of Pathology, The University of Chicago, Chicago, Illinois.
Wang Y; Department of Pathology, The University of Chicago, Chicago, Illinois.
Nilsen SP; Laboratory of Mucosal Barrier Pathobiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Turner JR; Laboratory of Mucosal Barrier Pathobiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Department of Pathology, The University of Chicago, Chicago, Illinois. Electronic address: .
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Źródło :
Gastroenterology [Gastroenterology] 2019 Nov; Vol. 157 (5), pp. 1323-1337. Date of Electronic Publication: 2019 Aug 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Apoptosis*
Caspase 3/*metabolism
Colitis/*enzymology
Colon/*enzymology
Epithelial Cells/*enzymology
Intestinal Mucosa/*enzymology
Occludin/*metabolism
Animals ; Caco-2 Cells ; Case-Control Studies ; Caspase 3/deficiency ; Caspase 3/genetics ; Colitis/chemically induced ; Colitis/genetics ; Colitis/pathology ; Colitis, Ulcerative/enzymology ; Colitis, Ulcerative/pathology ; Colon/pathology ; Crohn Disease/enzymology ; Crohn Disease/pathology ; Dextran Sulfate ; Disease Models, Animal ; Epithelial Cells/pathology ; Humans ; Intestinal Mucosa/pathology ; Mice, Inbred C57BL ; Mice, Knockout ; Occludin/deficiency ; Occludin/genetics ; Signal Transduction ; Trinitrobenzenesulfonic Acid ; Zonula Occludens-1 Protein/genetics ; Zonula Occludens-1 Protein/metabolism
Czasopismo naukowe
Tytuł :
Effects of environmental cocaine concentrations on COX and caspase-3 activity, GRP-78, ALT, CRP and blood glucose levels in the liver and kidney of the European eel (Anguilla anguilla).
Autorzy :
Capaldo A; Department of Biology, University of Naples Federico II, Via Cinthia, Edificio 7, 80126 Naples, Italy. Electronic address: .
Gay F; Department of Chemistry and Biology 'A. Zambelli', University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, Salerno, Italy.
Caputo I; Department of Chemistry and Biology 'A. Zambelli', University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, Salerno, Italy; ELFID (European Laboratory for Food-Induced Diseases), University of Naples Federico II, Via Pansini 5, 80131 Naples, Italy.
Lionetti L; Department of Chemistry and Biology 'A. Zambelli', University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, Salerno, Italy; ELFID (European Laboratory for Food-Induced Diseases), University of Naples Federico II, Via Pansini 5, 80131 Naples, Italy.
Paolella G; Department of Chemistry and Biology 'A. Zambelli', University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, Salerno, Italy.
Di Gregorio I; Department of Chemistry and Biology 'A. Zambelli', University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, Salerno, Italy.
Martucciello S; Department of Chemistry and Biology 'A. Zambelli', University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, Salerno, Italy.
Di Lorenzo M; Department of Biology, University of Naples Federico II, Via Cinthia, Edificio 7, 80126 Naples, Italy.
Rosati L; Department of Biology, University of Naples Federico II, Via Cinthia, Edificio 7, 80126 Naples, Italy.
Laforgia V; Department of Biology, University of Naples Federico II, Via Cinthia, Edificio 7, 80126 Naples, Italy.
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Źródło :
Ecotoxicology and environmental safety [Ecotoxicol Environ Saf] 2021 Jan 15; Vol. 208, pp. 111475. Date of Electronic Publication: 2020 Oct 15.
Typ publikacji :
Journal Article
MeSH Terms :
Anguilla/*physiology
Cocaine/*toxicity
Water Pollutants, Chemical/*toxicity
Alanine Transaminase/metabolism ; Anguilla/blood ; Animals ; Blood Glucose ; C-Reactive Protein/metabolism ; Caspase 3/metabolism ; Cocaine/analysis ; Electron Transport Complex IV/metabolism ; Illicit Drugs ; Kidney/metabolism ; Liver/metabolism
Czasopismo naukowe
Tytuł :
Chlorogenic acid abates male reproductive dysfunction in arsenic-exposed mice via attenuation of testicular oxido-inflammatory stress and apoptotic responses.
Autorzy :
El-Khadragy MF; Biology Department, Faculty of Science, Princess Nourah Bint Abdulrahman University, Riyadh, 11671, Saudi Arabia; Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, 11795, Egypt. Electronic address: .
Al-Megrin WA; Biology Department, Faculty of Science, Princess Nourah Bint Abdulrahman University, Riyadh, 11671, Saudi Arabia.
Alomar S; Doping Research Chair, Department of Zoology, College of Science, King Saud University, Riyadh, 11495, Saudi Arabia.
Alkhuriji AF; Department of Zoology, Faculty of Science, King Saud University, Riyadh, 11451, Saudi Arabia.
Metwally DM; Department of Zoology, Faculty of Science, King Saud University, Riyadh, 11451, Saudi Arabia; Department of Parasitology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44519, Egypt.
Mahgoub S; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Helwan University, Cairo, 11795, Egypt.
Amin HK; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Helwan University, Cairo, 11795, Egypt.
Habotta OA; Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516, Egypt.
Abdel Moneim AE; Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, 11795, Egypt.
Albeltagy RS; Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, 11795, Egypt.
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Źródło :
Chemico-biological interactions [Chem Biol Interact] 2021 Jan 05; Vol. 333, pp. 109333. Date of Electronic Publication: 2020 Nov 23.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis/*drug effects
Arsenic/*toxicity
Chlorogenic Acid/*pharmacology
Oxidative Stress/*drug effects
Reproduction/*drug effects
Testis/*drug effects
Testis/*physiopathology
Animals ; Antioxidants/metabolism ; Caspase 3/metabolism ; Cell Survival/drug effects ; Cytokines/metabolism ; Male ; Mice ; Organ Size/drug effects ; Sperm Count ; Spermatozoa/drug effects ; Spermatozoa/pathology ; Testis/metabolism ; Testis/pathology
Czasopismo naukowe
Tytuł :
Interferon regulatory factor 7 inhibits rat vascular smooth muscle cell proliferation and inflammation in monocrotaline-induced pulmonary hypertension.
Autorzy :
Deng Y; Department of Ultrasound, The First Affiliated Hospital of Guangxi Medical University, Nanning, China. Electronic address: .
Guo SL; Department of Ultrasound, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Li JQ; The Experimental Center of Guangxi Medical University, Nanning, China.
Xie SS; Department of Ultrasound, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Zhou YC; Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Wei B; Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Wang Q; Department of Ultrasound, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Wang F; Department of Ultrasound, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
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Źródło :
Life sciences [Life Sci] 2021 Jan 01; Vol. 264, pp. 118709. Date of Electronic Publication: 2020 Nov 02.
Typ publikacji :
Journal Article
MeSH Terms :
Hypertension, Pulmonary/*chemically induced
Hypertension, Pulmonary/*pathology
Inflammation/*pathology
Interferon Regulatory Factor-7/*metabolism
Muscle, Smooth, Vascular/*pathology
Myocytes, Smooth Muscle/*pathology
Activating Transcription Factor 3/metabolism ; Animals ; Apoptosis ; Caspase 3/metabolism ; Cell Proliferation ; Cells, Cultured ; Core Binding Factor Alpha 1 Subunit/metabolism ; Cyclin D1/metabolism ; Dependovirus/metabolism ; Heart Ventricles/pathology ; Heart Ventricles/physiopathology ; Hemodynamics ; Hypertension, Pulmonary/metabolism ; Hypertension, Pulmonary/physiopathology ; Inflammation/complications ; Lung/pathology ; Lung/physiopathology ; Male ; Monocrotaline ; Myocytes, Smooth Muscle/metabolism ; Proliferating Cell Nuclear Antigen/metabolism ; Rats, Sprague-Dawley ; Receptor for Advanced Glycation End Products/metabolism ; Signal Transduction ; Survivin/metabolism ; Up-Regulation ; Vascular Remodeling ; bcl-2-Associated X Protein/metabolism
Czasopismo naukowe
Tytuł :
Phosphorylation of levan by microwave-assisted synthesis enhanced anticancer ability.
Autorzy :
Huang TY; Department of Orthopedic Surgery, Mackay Memorial Hospital, Taipei 10449, Taiwan.
Huang MY; Fisheries Research Institute, Council of Agriculture, Keelung 20246, Taiwan.
Tsai CK; Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 10608, Taiwan.
Su WT; Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 10608, Taiwan. Electronic address: .
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Źródło :
Journal of bioscience and bioengineering [J Biosci Bioeng] 2021 Jan; Vol. 131 (1), pp. 98-106. Date of Electronic Publication: 2020 Sep 19.
Typ publikacji :
Journal Article
MeSH Terms :
Microwaves*
Antineoplastic Agents/*chemistry
Antineoplastic Agents/*pharmacology
Fructans/*chemistry
Fructans/*pharmacology
A549 Cells ; Antineoplastic Agents/chemical synthesis ; Apoptosis/drug effects ; Caspase 3/metabolism ; Cell Proliferation/drug effects ; Chemistry Techniques, Synthetic ; Fructans/chemical synthesis ; HCT116 Cells ; Humans ; Phosphorylation ; Proto-Oncogene Proteins c-bcl-2/metabolism
Czasopismo naukowe
Tytuł :
Nephroprotective effect of exogenous hydrogen sulfide donor against cyclophosphamide-induced toxicity is mediated by Nrf2/HO-1/NF-κB signaling pathway.
Autorzy :
Waz S; Department of Biochemistry, Faculty of Pharmacy, Minia University, El-Minia, Egypt. Electronic address: .
Heeba GH; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, El-Minia, Egypt.
Hassanin SO; Department of Biochemistry, Faculty of Pharmacy, MTI University, Cairo, Egypt.
Abdel-Latif RG; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, El-Minia, Egypt.
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Źródło :
Life sciences [Life Sci] 2021 Jan 01; Vol. 264, pp. 118630. Date of Electronic Publication: 2020 Oct 22.
Typ publikacji :
Journal Article
MeSH Terms :
Cyclophosphamide/*adverse effects
Heme Oxygenase (Decyclizing)/*metabolism
Hydrogen Sulfide/*pharmacology
Kidney/*drug effects
NF-E2-Related Factor 2/*metabolism
NF-kappa B p50 Subunit/*metabolism
Animals ; Antioxidants/pharmacology ; Apoptosis ; Caspase 3/metabolism ; Enzyme-Linked Immunosorbent Assay ; Immunohistochemistry ; Immunosuppressive Agents/adverse effects ; Inflammation ; Kidney Diseases/chemically induced ; Male ; NAD(P)H Dehydrogenase (Quinone)/metabolism ; Oxidative Stress ; Rats ; Rats, Wistar ; Signal Transduction
Czasopismo naukowe

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