Discovery of first-in-class nanomolar inhibitors of heptosyltransferase I reveals a new aminoglycoside target and potential alternative mechanism of action.
Autorzy:
Milicaj J; Department of Chemistry, Wesleyan University, Middletown, CT, 06459, USA. Hassan BA; Department of Chemistry, Wesleyan University, Middletown, CT, 06459, USA. Cote JM; Department of Chemistry, Wesleyan University, Middletown, CT, 06459, USA. Ramirez-Mondragon CA; Bioinformatics and Computational Biology Program, University of Minnesota, Minneapolis, MN, 55455, USA. Jaunbocus N; Department of Chemistry, Wesleyan University, Middletown, CT, 06459, USA. Rafalowski A; Department of Chemistry, Wesleyan University, Middletown, CT, 06459, USA. Patel KR; Department of Integrative Biology and Physiology, Medical School, University of Minnesota, Minneapolis, MN, 55455, USA. CastroCD; Department of Chemistry, Wesleyan University, Middletown, CT, 06459, USA. Muthyala R; Department of Experimental and Clinical Pharmacology, College Pharmacy, University of Minnesota, Minneapolis, MN, 55455, USA. Sham YY; Department of Integrative Biology and Physiology, Medical School, University of Minnesota, Minneapolis, MN, 55455, USA. .; Bioinformatics and Computational Biology Program, University of Minnesota, Minneapolis, MN, 55455, USA. . Taylor EA; Department of Chemistry, Wesleyan University, Middletown, CT, 06459, USA. .
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Źródło:
Scientific reports [Sci Rep] 2022 May 04; Vol. 12 (1), pp. 7302. Date of Electronic Publication: 2022 May 04.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
Diversity in recognition and function of human γδ T cells.
Autorzy:
CastroCD; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA. Boughter CT; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.; Graduate Program in Biophysical Sciences, University of Chicago, Chicago, IL, USA. Broughton AE; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.; Committee on Immunology, University of Chicago, Chicago, IL, USA. Ramesh A; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.; Interdisciplinary Scientist Training Program, University of Chicago, Chicago, IL, USA. Adams EJ; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.; Graduate Program in Biophysical Sciences, University of Chicago, Chicago, IL, USA.; Committee on Immunology, University of Chicago, Chicago, IL, USA.; Interdisciplinary Scientist Training Program, University of Chicago, Chicago, IL, USA.
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Źródło:
Immunological reviews [Immunol Rev] 2020 Nov; Vol. 298 (1), pp. 134-152. Date of Electronic Publication: 2020 Nov 02.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Review
Coevolution of T-cell receptors with MHC and non-MHC ligands.
Autorzy:
CastroCD; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.; Committee on Immunology, University of Chicago, Chicago, IL, USA. Luoma AM; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.; Committee on Immunology, University of Chicago, Chicago, IL, USA. Adams EJ; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.; Committee on Immunology, University of Chicago, Chicago, IL, USA.; Committee on Cancer Biology, University of Chicago, Chicago, IL, USA.
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