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Tytuł :
Metabolic Acidosis Alters Expression of Slc22 Transporters in Mouse Kidney.
Autorzy :
Gottier Nwafor J; Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland.
Nowik M; Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland.
Anzai N; Department of Pharmacology, Chiba University Graduate School of Medicine, Chiba, Japan.
Endou H; Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Japan.
Wagner CA; Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland, .
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Źródło :
Kidney & blood pressure research [Kidney Blood Press Res] 2020; Vol. 45 (2), pp. 263-274. Date of Electronic Publication: 2020 Feb 14.
Typ publikacji :
Journal Article
MeSH Terms :
Acidosis/*metabolism
Catecholamine Plasma Membrane Transport Proteins/*biosynthesis
Kidney Diseases/*pathology
Acidosis/blood ; Acidosis/pathology ; Acidosis/urine ; Animals ; Catecholamine Plasma Membrane Transport Proteins/genetics ; Catecholamine Plasma Membrane Transport Proteins/metabolism ; Kidney Diseases/blood ; Kidney Diseases/metabolism ; Kidney Diseases/urine ; Male ; Mice ; Mice, Inbred C57BL ; Octamer Transcription Factor-1/biosynthesis ; Octamer Transcription Factor-1/genetics ; Octamer Transcription Factor-1/metabolism ; Organic Anion Transporters/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Uric Acid/blood ; Uric Acid/urine
Czasopismo naukowe
Tytuł :
Organic cation transporter and multidrug and toxin extrusion 1 co-mediated interaction between metformin and berberine.
Autorzy :
Shi R; Department of Pharmacology, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Xu Z; Department of Pharmacology, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Xu X; Department of Pharmacology, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Jin J; Department of Pharmacology, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Zhao Y; Department of Pharmacology, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Wang T; Department of Pharmacology, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Li Y; Department of Pharmacology, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Ma Y; Department of Pharmacology, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address: .
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Źródło :
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2019 Jan 15; Vol. 127, pp. 282-290. Date of Electronic Publication: 2018 Nov 11.
Typ publikacji :
Journal Article
MeSH Terms :
Antiporters/*metabolism
Berberine/*pharmacokinetics
Catecholamine Plasma Membrane Transport Proteins/*metabolism
Hypoglycemic Agents/*pharmacokinetics
Metformin/*pharmacokinetics
Organic Cation Transport Proteins/*metabolism
Organic Cation Transporter 2/*metabolism
Adipose Tissue/metabolism ; Animals ; Antiporters/genetics ; Berberine/blood ; Catecholamine Plasma Membrane Transport Proteins/genetics ; Dogs ; Drug Interactions ; Female ; Hypoglycemic Agents/blood ; Intestinal Mucosa/metabolism ; Kidney/metabolism ; Liver/metabolism ; Madin Darby Canine Kidney Cells ; Male ; Metformin/blood ; Muscle, Skeletal/metabolism ; Organic Cation Transport Proteins/genetics ; Organic Cation Transporter 2/genetics ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Pharmacological profiles of compounds in preworkout supplements ("boosters").
Autorzy :
Rickli A; Division of Clinical Pharmacology and Toxicology, Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland.
Hoener MC; Neuroscience Research, pRED, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
Liechti ME; Division of Clinical Pharmacology and Toxicology, Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland. Electronic address: .
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2019 Sep 15; Vol. 859, pp. 172515. Date of Electronic Publication: 2019 Jun 29.
Typ publikacji :
Journal Article
MeSH Terms :
Exercise/*physiology
Performance-Enhancing Substances/*pharmacology
Biogenic Monoamines/metabolism ; Biological Transport/drug effects ; Catecholamine Plasma Membrane Transport Proteins/metabolism ; Dietary Supplements ; HEK293 Cells ; Humans ; Performance-Enhancing Substances/metabolism ; Phenethylamines/metabolism ; Phenethylamines/pharmacology
Czasopismo naukowe
Tytuł :
The flight response impairs cytoprotective mechanisms by activating the insulin pathway.
Autorzy :
De Rosa MJ; Instituto de Investigaciones Bioquímicas de Bahía Blanca (CONICET), Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur, Bahía Blanca, Argentina.
Veuthey T; Instituto de Investigaciones Bioquímicas de Bahía Blanca (CONICET), Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur, Bahía Blanca, Argentina.
Florman J; Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA, USA.
Grant J; Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA, USA.
Blanco MG; Instituto de Investigaciones Bioquímicas de Bahía Blanca (CONICET), Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur, Bahía Blanca, Argentina.
Andersen N; Instituto de Investigaciones Bioquímicas de Bahía Blanca (CONICET), Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur, Bahía Blanca, Argentina.
Donnelly J; Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA, USA.
Rayes D; Instituto de Investigaciones Bioquímicas de Bahía Blanca (CONICET), Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur, Bahía Blanca, Argentina. .; Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA, USA. .
Alkema MJ; Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA, USA. .
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Źródło :
Nature [Nature] 2019 Sep; Vol. 573 (7772), pp. 135-138. Date of Electronic Publication: 2019 Aug 28.
Typ publikacji :
Journal Article
MeSH Terms :
Cytoprotection*
Caenorhabditis elegans/*cytology
Caenorhabditis elegans/*physiology
Insulin/*metabolism
Tyramine/*metabolism
Active Transport, Cell Nucleus ; Animals ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/metabolism ; Cell Nucleus/metabolism ; Forkhead Transcription Factors/metabolism ; Insulin-Like Growth Factor I/metabolism ; Intestinal Mucosa/metabolism ; Longevity ; Neurons/metabolism ; Receptors, Adrenergic/metabolism ; Receptors, Catecholamine/metabolism ; Signal Transduction ; Stress, Psychological
Czasopismo naukowe
Tytuł :
Comparison of uptake transporter functions in hepatocytes in different species to determine the optimal model for evaluating drug transporter activities in humans.
Autorzy :
Liao M; a Takeda Pharmaceuticals, DMPK , Cambridge , MA , USA.
Zhu Q; b Takeda Pharmaceuticals International Co , Cambridge , MA , USA.
Zhu A; b Takeda Pharmaceuticals International Co , Cambridge , MA , USA.
Gemski C; b Takeda Pharmaceuticals International Co , Cambridge , MA , USA.
Ma B; b Takeda Pharmaceuticals International Co , Cambridge , MA , USA.
Guan E; a Takeda Pharmaceuticals, DMPK , Cambridge , MA , USA.
Li AP; c IVAL , Columbia , MD , USA.
Xiao G; b Takeda Pharmaceuticals International Co , Cambridge , MA , USA.
Xia CQ; b Takeda Pharmaceuticals International Co , Cambridge , MA , USA.
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Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2019 Jul; Vol. 49 (7), pp. 852-862. Date of Electronic Publication: 2018 Sep 21.
Typ publikacji :
Journal Article
MeSH Terms :
Models, Biological*
Catecholamine Plasma Membrane Transport Proteins/*metabolism
Hepatocytes/*metabolism
Octamer Transcription Factor-1/*metabolism
Organic Anion Transporters, Sodium-Dependent/*metabolism
Symporters/*metabolism
Adult ; Animals ; Atorvastatin/pharmacokinetics ; Atorvastatin/pharmacology ; Biological Transport, Active ; Estradiol/analogs & derivatives ; Estradiol/pharmacokinetics ; Estradiol/pharmacology ; Female ; Hepatocytes/cytology ; Humans ; Male ; Metformin/pharmacokinetics ; Metformin/pharmacology ; Middle Aged ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Association of serotoninergic pathway gene variants with elite athletic status in the Polish population.
Autorzy :
Peplonska B; a Department of Neurodegenerative Disorders , Mossakowski Medical Research Centre Polish Academy of Sciences , Warsaw , Poland.
Safranow K; b Department of Biochemistry and Medical Chemistry , Pomeranian Medical University , Szczecin , Poland.
Adamczyk J; c Department of Sport's Theory , Jozef Pilsudski University of Physical Education in Warsaw , Warsaw , Poland.
Boguszewski D; d Department of Rehabilitation, Physiotherapy Division , Medical University of Warsaw , Warsaw , Poland.
Szymański K; e Department of Medical Genetics , Centre for Biostructure, Medical University of Warsaw , Warsaw , Poland.
Soltyszewski I; f Department of Criminology and Forensic Medicine , Warmia and Mazury University , Olsztyn , Poland.
Barczak A; a Department of Neurodegenerative Disorders , Mossakowski Medical Research Centre Polish Academy of Sciences , Warsaw , Poland.
Siewierski M; c Department of Sport's Theory , Jozef Pilsudski University of Physical Education in Warsaw , Warsaw , Poland.
Ploski R; e Department of Medical Genetics , Centre for Biostructure, Medical University of Warsaw , Warsaw , Poland.
Sozanski H; c Department of Sport's Theory , Jozef Pilsudski University of Physical Education in Warsaw , Warsaw , Poland.
Zekanowski C; c Department of Sport's Theory , Jozef Pilsudski University of Physical Education in Warsaw , Warsaw , Poland.
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Źródło :
Journal of sports sciences [J Sports Sci] 2019 Jul; Vol. 37 (14), pp. 1655-1662. Date of Electronic Publication: 2019 Mar 05.
Typ publikacji :
Journal Article
MeSH Terms :
Polymorphism, Single Nucleotide*
Athletic Performance/*physiology
Emotions/*physiology
Receptors, Serotonin/*genetics
Adult ; Anxiety/genetics ; DNA-Binding Proteins/genetics ; Female ; Genotype ; Humans ; Hypothalamo-Hypophyseal System/physiology ; Male ; Nuclear Proteins/genetics ; Pituitary-Adrenal System/physiology ; Poland ; Receptor, Serotonin, 5-HT1B/genetics ; Receptor, Serotonin, 5-HT2C/genetics ; Receptors, Catecholamine/genetics ; Stress, Psychological/genetics ; Transcription Factors ; Young Adult
Czasopismo naukowe
Tytuł :
Rate-Determining and Rate-Limiting Steps in the Clearance and Excretion of a Potent and Selective p21-Activated Kinase Inhibitor: A Case Study of Rapid Hepatic Uptake and Slow Elimination in Rat.
Autorzy :
Fan PW; Genentech, Inc. 1 DNA Way, MS 412a, South San Francisco, CA 94080, USA. .
Chen JZ
Allan Jaochico M
La H
Liu N
Mulder T
Cass RT
Durk M
Messick K
Valle N
Liu S
Lee W
Crawford JJ
Rudolf J
Murray LJ
Cyrus Khojasteh S
Wright M
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Źródło :
Drug metabolism letters [Drug Metab Lett] 2016; Vol. 10 (2), pp. 91-100.
Typ publikacji :
Journal Article
MeSH Terms :
Catecholamine Plasma Membrane Transport Proteins/*metabolism
Liver/*metabolism
Protein Kinase Inhibitors/*pharmacokinetics
Pyrazoles/*pharmacokinetics
Pyrimidines/*pharmacokinetics
p21-Activated Kinases/*antagonists & inhibitors
Animals ; Catecholamine Plasma Membrane Transport Proteins/genetics ; Female ; Male ; Mice ; Mice, Knockout ; Organic Cation Transport Proteins/metabolism ; Rats ; Rats, Sprague-Dawley ; Triazoles/pharmacology
Czasopismo naukowe
Tytuł :
In vivo pharmacodynamic and pharmacokinetic effects of metformin mediated by the gut microbiota in rats.
Autorzy :
Wu B; Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China; Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatrics, Xiangya Hospital, Central South University, Changsha 410008, China.
Chen M; Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China; Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatrics, Xiangya Hospital, Central South University, Changsha 410008, China.
Gao Y; Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China; Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatrics, Xiangya Hospital, Central South University, Changsha 410008, China.
Hu J; Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China; Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatrics, Xiangya Hospital, Central South University, Changsha 410008, China.
Liu M; Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China; Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatrics, Xiangya Hospital, Central South University, Changsha 410008, China.
Zhang W; Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China; Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatrics, Xiangya Hospital, Central South University, Changsha 410008, China. Electronic address: .
Huang W; Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, China; Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha, Hunan, China; National Clinical Research Center for Geriatrics, Xiangya Hospital, Central South University, Changsha 410008, China. Electronic address: .
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Źródło :
Life sciences [Life Sci] 2019 Jun 01; Vol. 226, pp. 185-192. Date of Electronic Publication: 2019 Apr 03.
Typ publikacji :
Journal Article
MeSH Terms :
Gastrointestinal Microbiome/*drug effects
Metformin/*pharmacology
Administration, Oral ; Animals ; Blood Glucose ; Catecholamine Plasma Membrane Transport Proteins/metabolism ; China ; Chromatography, High Pressure Liquid ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/microbiology ; Disease Models, Animal ; Hyperlipidemias ; Hypoglycemic Agents ; Liver/metabolism ; Male ; Metformin/pharmacokinetics ; Rats ; Tandem Mass Spectrometry
Czasopismo naukowe
Tytuł :
Design, synthesis and in vitro evaluation of a Dopa-organoboron compound that acts as a bladder relaxant through non-catecholamine receptors.
Autorzy :
Ocampo-Néstor AL; Departamento de Fisiología, Laboratorio de Investigación en Bioquímica y Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, 11340, México, Mexico.
López-Mayorga RM; Departamento de Fisiología, Laboratorio de Investigación en Bioquímica y Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, 11340, México, Mexico.
Castillo-Henkel EF; Departamento de Fisiología, Laboratorio de Investigación en Bioquímica y Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, 11340, México, Mexico.
Padilla-Martínez II; Unidad Profesional Interdisciplinaria de Biotecnología, Instituto Politécnico Nacional, Avenida Acueducto s/n, Barrio La Laguna Ticomán, 07340, México, Mexico.
Trujillo-Ferrara JG; Departamento de Fisiología, Laboratorio de Investigación en Bioquímica y Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, 11340, México, Mexico. .
Soriano-Ursúa MA; Departamento de Fisiología, Laboratorio de Investigación en Bioquímica y Sección de Estudios de Posgrado e Investigación, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, 11340, México, Mexico. .
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Źródło :
Molecular diversity [Mol Divers] 2019 May; Vol. 23 (2), pp. 361-370. Date of Electronic Publication: 2018 Oct 03.
Typ publikacji :
Journal Article
MeSH Terms :
Boron*/chemistry
Boron*/pharmacology
Dihydroxyphenylalanine*/chemistry
Dihydroxyphenylalanine*/pharmacology
Parasympatholytics*/chemistry
Parasympatholytics*/pharmacology
Animals ; Aorta/drug effects ; Aorta/physiology ; Drug Design ; In Vitro Techniques ; Male ; Models, Molecular ; Muscle, Smooth/drug effects ; Muscle, Smooth/physiology ; Rats, Wistar ; Receptors, Catecholamine ; Urinary Bladder/drug effects ; Urinary Bladder/physiology
Czasopismo naukowe
Tytuł :
Stereochemistry of phase-1 metabolites of mephedrone determines their effectiveness as releasers at the serotonin transporter.
Autorzy :
Mayer FP; Medical University of Vienna, Center for Physiology and Pharmacology, Institute of Pharmacology, Vienna, Austria.
Cintulova D; Institute of Applied Synthetic Chemistry, Vienna University of Technology, Vienna, Austria.
Pittrich DA; Medical University of Vienna, Center for Physiology and Pharmacology, Institute of Pharmacology, Vienna, Austria.
Wimmer L; Institute of Applied Synthetic Chemistry, Vienna University of Technology, Vienna, Austria.
Luethi D; University Hospital Basel and University of Basel, Division of Clinical Pharmacology and Toxicology, Department of Biomedicine, Basel, Switzerland.
Holy M; Medical University of Vienna, Center for Physiology and Pharmacology, Institute of Pharmacology, Vienna, Austria.
Jaentsch K; Medical University of Vienna, Center for Physiology and Pharmacology, Institute of Pharmacology, Vienna, Austria.
Tischberger S; Doping Control Laboratory, Seibersdorf Labor GmbH, Seibersdorf, Austria.
Gmeiner G; Doping Control Laboratory, Seibersdorf Labor GmbH, Seibersdorf, Austria.
Hoener MC; Neuroscience Research, pRED, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
Liechti ME; University Hospital Basel and University of Basel, Division of Clinical Pharmacology and Toxicology, Department of Biomedicine, Basel, Switzerland.
Mihovilovic MD; Institute of Applied Synthetic Chemistry, Vienna University of Technology, Vienna, Austria.
Sitte HH; Medical University of Vienna, Center for Physiology and Pharmacology, Institute of Pharmacology, Vienna, Austria; Center for Addiction Research and Science - AddRess, Medical University Vienna, Waehringerstrasse 13A, 1090 Vienna, Austria. Electronic address: .
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Źródło :
Neuropharmacology [Neuropharmacology] 2019 Apr; Vol. 148, pp. 199-209. Date of Electronic Publication: 2019 Jan 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Methadone/*analogs & derivatives
Serotonin Uptake Inhibitors/*pharmacology
Adrenergic Uptake Inhibitors/pharmacology ; Animals ; Cells, Cultured ; Dopamine Uptake Inhibitors/pharmacology ; Dose-Response Relationship, Drug ; Humans ; Methadone/pharmacology ; Methadone/urine ; Mice ; Radioligand Assay ; Rats ; Receptors, Catecholamine/drug effects ; Receptors, Serotonin/drug effects ; Stereoisomerism
Czasopismo naukowe
Tytuł :
Rat Organic Cation Transporter 1 Contains Three Binding Sites for Substrate 1-Methyl-4-phenylpyridinium per Monomer.
Autorzy :
Keller T; Institute of Anatomy and Cell Biology (T.K., V.G., H.K.) and Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs-Institute (T.K., T.D.M., H.K.), University of Würzburg, Würzburg, Germany; and Department of Biophysical Chemistry, University of Frankfurt, Frankfurt am Main, Germany (V.D., F.B.).
Gorboulev V; Institute of Anatomy and Cell Biology (T.K., V.G., H.K.) and Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs-Institute (T.K., T.D.M., H.K.), University of Würzburg, Würzburg, Germany; and Department of Biophysical Chemistry, University of Frankfurt, Frankfurt am Main, Germany (V.D., F.B.).
Mueller TD; Institute of Anatomy and Cell Biology (T.K., V.G., H.K.) and Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs-Institute (T.K., T.D.M., H.K.), University of Würzburg, Würzburg, Germany; and Department of Biophysical Chemistry, University of Frankfurt, Frankfurt am Main, Germany (V.D., F.B.).
Dötsch V; Institute of Anatomy and Cell Biology (T.K., V.G., H.K.) and Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs-Institute (T.K., T.D.M., H.K.), University of Würzburg, Würzburg, Germany; and Department of Biophysical Chemistry, University of Frankfurt, Frankfurt am Main, Germany (V.D., F.B.).
Bernhard F; Institute of Anatomy and Cell Biology (T.K., V.G., H.K.) and Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs-Institute (T.K., T.D.M., H.K.), University of Würzburg, Würzburg, Germany; and Department of Biophysical Chemistry, University of Frankfurt, Frankfurt am Main, Germany (V.D., F.B.).
Koepsell H; Institute of Anatomy and Cell Biology (T.K., V.G., H.K.) and Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs-Institute (T.K., T.D.M., H.K.), University of Würzburg, Würzburg, Germany; and Department of Biophysical Chemistry, University of Frankfurt, Frankfurt am Main, Germany (V.D., F.B.) .
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Źródło :
Molecular pharmacology [Mol Pharmacol] 2019 Feb; Vol. 95 (2), pp. 169-182. Date of Electronic Publication: 2018 Nov 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
1-Methyl-4-phenylpyridinium/*metabolism
Catecholamine Plasma Membrane Transport Proteins/*metabolism
Animals ; Binding Sites ; Green Fluorescent Proteins/metabolism ; Mutagenesis/physiology ; Phospholipids/metabolism ; Proteolipids/metabolism ; Rats
Czasopismo naukowe
Tytuł :
Catecholamine dysregulation and neurodegenerative disease: From molecular mechanisms to circuit dysfunction.
Autorzy :
Van Bockstaele EJ; Department of Pharmacology and Physiology, College of Medicine, Drexel University, Philadelphia, PA 19102, United States. Electronic address: .
Ross JA; Department of Pharmacology and Physiology, College of Medicine, Drexel University, Philadelphia, PA 19102, United States.
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Źródło :
Brain research [Brain Res] 2019 Jan 01; Vol. 1702, pp. 1-2. Date of Electronic Publication: 2018 May 18.
Typ publikacji :
Editorial; Introductory Journal Article
MeSH Terms :
Catecholamines/*metabolism
Catecholamines/*physiology
Neurodegenerative Diseases/*metabolism
Alzheimer Disease/metabolism ; Humans ; Receptors, Catecholamine/metabolism
Czasopismo naukowe
Tytuł :
Interspecies variations in Bordetella catecholamine receptor gene regulation and function.
Autorzy :
Brickman TJ; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Suhadolc RJ; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Armstrong SK; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA .
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Źródło :
Infection and immunity [Infect Immun] 2015 Dec; Vol. 83 (12), pp. 4639-52. Date of Electronic Publication: 2015 Sep 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Gene Expression Regulation, Bacterial*
Bacterial Outer Membrane Proteins/*immunology
Bordetella Infections/*immunology
Bordetella bronchiseptica/*pathogenicity
Bordetella pertussis/*pathogenicity
Receptors, Catecholamine/*immunology
Receptors, Cell Surface/*immunology
Animals ; Bacterial Outer Membrane Proteins/genetics ; Bacterial Proteins/genetics ; Bacterial Proteins/immunology ; Bordetella Infections/microbiology ; Bordetella Infections/pathology ; Bordetella bronchiseptica/genetics ; Bordetella bronchiseptica/immunology ; Bordetella bronchiseptica/metabolism ; Bordetella pertussis/genetics ; Bordetella pertussis/immunology ; Bordetella pertussis/metabolism ; Catecholamines/immunology ; Catecholamines/metabolism ; Humans ; Iron/immunology ; Iron/metabolism ; Mice ; Mice, Inbred BALB C ; Protein Isoforms/genetics ; Protein Isoforms/immunology ; Receptors, Catecholamine/genetics ; Receptors, Cell Surface/genetics ; Siderophores/immunology ; Siderophores/metabolism ; Species Specificity ; Transcription Factors/genetics ; Transcription Factors/immunology ; Virulence
Czasopismo naukowe
Tytuł :
Involvement of organic cation transporters in the clearance and milk secretion of thiamine in mice.
Autorzy :
Kato K; Drug Safety and Pharmacokinetics Laboratories, Taisho Pharmaceutical Co. Ltd., Saitama, Japan.
Moriyama C
Ito N
Zhang X
Hachiuma K
Hagima N
Iwata K
Yamaguchi J
Maeda K
Ito K
Suzuki H
Sugiyama Y
Kusuhara H
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Źródło :
Pharmaceutical research [Pharm Res] 2015 Jul; Vol. 32 (7), pp. 2192-204. Date of Electronic Publication: 2015 Feb 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Catecholamine Plasma Membrane Transport Proteins/*metabolism
Hepatocytes/*metabolism
Milk/*metabolism
Organic Cation Transport Proteins/*metabolism
Thiamine/*pharmacokinetics
Animals ; Biological Transport ; Catecholamine Plasma Membrane Transport Proteins/genetics ; Chromatography, Liquid ; HEK293 Cells ; Humans ; Lactation ; Male ; Metabolic Clearance Rate ; Mice, Knockout ; Organic Cation Transport Proteins/genetics ; Tandem Mass Spectrometry ; Thiamine/blood ; Thiamine/metabolism ; Tissue Distribution ; Transfection
Czasopismo naukowe
Tytuł :
Decreased liver distribution of entecavir is related to down-regulation of Oat2/Oct1 and up-regulation of Mrp1/2/3/5 in rat liver fibrosis.
Autorzy :
Xu Q; Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, China.
Wang C; Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, China; Provincial Key Laboratory for Pharmacokinetics and Transport, Liaoning, Dalian Medical University, China.
Liu Q; Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, China; Provincial Key Laboratory for Pharmacokinetics and Transport, Liaoning, Dalian Medical University, China.
Meng Q; Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, China; Provincial Key Laboratory for Pharmacokinetics and Transport, Liaoning, Dalian Medical University, China.
Sun H; Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, China; Provincial Key Laboratory for Pharmacokinetics and Transport, Liaoning, Dalian Medical University, China.
Peng J; Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, China; Provincial Key Laboratory for Pharmacokinetics and Transport, Liaoning, Dalian Medical University, China.
Sun P; Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, China; Provincial Key Laboratory for Pharmacokinetics and Transport, Liaoning, Dalian Medical University, China.
Huo X; Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, China; Provincial Key Laboratory for Pharmacokinetics and Transport, Liaoning, Dalian Medical University, China.
Liu K; Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, China; Provincial Key Laboratory for Pharmacokinetics and Transport, Liaoning, Dalian Medical University, China. Electronic address: .
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Źródło :
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2015 Apr 25; Vol. 71, pp. 73-9. Date of Electronic Publication: 2015 Feb 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antiviral Agents/*pharmacology
Catecholamine Plasma Membrane Transport Proteins/*genetics
Guanine/*analogs & derivatives
Liver/*drug effects
Multidrug Resistance-Associated Proteins/*genetics
Organic Anion Transporters, Sodium-Independent/*genetics
Alanine Transaminase/blood ; Animals ; Antiviral Agents/pharmacokinetics ; Aspartate Aminotransferases/blood ; Catecholamine Plasma Membrane Transport Proteins/metabolism ; Down-Regulation ; Fibrosis ; Guanine/pharmacokinetics ; Guanine/pharmacology ; Liver/metabolism ; Liver/pathology ; Male ; Multidrug Resistance-Associated Proteins/metabolism ; Organic Anion Transporters, Sodium-Independent/metabolism ; RNA, Messenger/metabolism ; Rats, Wistar ; Thioacetamide ; Up-Regulation
Czasopismo naukowe
Tytuł :
Amplification and Suppression of Distinct Brainwide Activity Patterns by Catecholamines.
Autorzy :
van den Brink RL; Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany, .; Institute of Psychology, Leiden University, 2333AK Leiden, The Netherlands.; Leiden Institute for Brain and Cognition, 2333AK Leiden, The Netherlands.
Nieuwenhuis S; Institute of Psychology, Leiden University, 2333AK Leiden, The Netherlands.; Leiden Institute for Brain and Cognition, 2333AK Leiden, The Netherlands.
Donner TH; Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.; Department of Psychology, University of Amsterdam, 1018WT Amsterdam, The Netherlands, and.; Amsterdam Center for Brain and Cognition, Institute for Interdisciplinary Studies, 1098XH Amsterdam, The Netherlands.
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Źródło :
The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2018 Aug 22; Vol. 38 (34), pp. 7476-7491. Date of Electronic Publication: 2018 Jul 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Connectome*
Brain/*physiology
Catecholamines/*physiology
Adrenergic Uptake Inhibitors/pharmacology ; Atomoxetine Hydrochloride/pharmacology ; Brain Chemistry ; Cross-Over Studies ; Datasets as Topic ; Double-Blind Method ; Female ; Functional Neuroimaging ; Humans ; Magnetic Resonance Imaging ; Male ; Nerve Tissue Proteins/analysis ; Nerve Tissue Proteins/genetics ; Receptors, Catecholamine/analysis ; Receptors, Catecholamine/genetics ; Rest
Czasopismo naukowe
Tytuł :
Antihyperalgesic Activity of Atomoxetine on Diabetes-Induced Neuropathic Pain: Contribution of Noradrenergic and Dopaminergic Systems.
Autorzy :
Barbaros MB; Department of Pharmacology, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey. .
Can ÖD; Department of Pharmacology, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey. .
Üçel Uİ; Department of Pharmacology, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey. .
Turan Yücel N; Department of Pharmacology, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey. .
Demir Özkay Ü; Department of Pharmacology, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey. .
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Źródło :
Molecules (Basel, Switzerland) [Molecules] 2018 Aug 19; Vol. 23 (8). Date of Electronic Publication: 2018 Aug 19.
Typ publikacji :
Journal Article
MeSH Terms :
Atomoxetine Hydrochloride/*pharmacology
Catecholamines/*metabolism
Diabetic Neuropathies/*complications
Neuralgia/*etiology
Neuralgia/*metabolism
Receptors, Catecholamine/*metabolism
Animals ; Disease Models, Animal ; Hyperalgesia/drug therapy ; Hyperalgesia/etiology ; Hyperalgesia/metabolism ; Male ; Motor Activity ; Neuralgia/drug therapy ; Neuralgia/physiopathology ; Pain Management ; Rats
Czasopismo naukowe
Tytuł :
Assay Conditions Influence Affinities of Rat Organic Cation Transporter 1: Analysis of Mutagenesis in the Modeled Outward-Facing Cleft by Measuring Effects of Substrates and Inhibitors on Initial Uptake.
Autorzy :
Gorboulev V; Institute of Anatomy and Cell Biology, University of Würzburg, Würzburg, Germany (V.G.,S.R. C.M.A., U.R. H.K.); Institute of Clinical Pharmacology, University Medical Center, Georg-August University, Göttingen, Germany (M.J.M., M.V.T.); Institute of Pharmacology, Center of Drug Absorption and Transport, University Medical Center Greifswald, Greifswald, Germany (M.V.T.); and Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs-Institute, University of Würzburg, Würzburg, Germany (T.D.M., H.K.).
Rehman S; Institute of Anatomy and Cell Biology, University of Würzburg, Würzburg, Germany (V.G.,S.R. C.M.A., U.R. H.K.); Institute of Clinical Pharmacology, University Medical Center, Georg-August University, Göttingen, Germany (M.J.M., M.V.T.); Institute of Pharmacology, Center of Drug Absorption and Transport, University Medical Center Greifswald, Greifswald, Germany (M.V.T.); and Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs-Institute, University of Würzburg, Würzburg, Germany (T.D.M., H.K.).
Albert CM; Institute of Anatomy and Cell Biology, University of Würzburg, Würzburg, Germany (V.G.,S.R. C.M.A., U.R. H.K.); Institute of Clinical Pharmacology, University Medical Center, Georg-August University, Göttingen, Germany (M.J.M., M.V.T.); Institute of Pharmacology, Center of Drug Absorption and Transport, University Medical Center Greifswald, Greifswald, Germany (M.V.T.); and Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs-Institute, University of Würzburg, Würzburg, Germany (T.D.M., H.K.).
Roth U; Institute of Anatomy and Cell Biology, University of Würzburg, Würzburg, Germany (V.G.,S.R. C.M.A., U.R. H.K.); Institute of Clinical Pharmacology, University Medical Center, Georg-August University, Göttingen, Germany (M.J.M., M.V.T.); Institute of Pharmacology, Center of Drug Absorption and Transport, University Medical Center Greifswald, Greifswald, Germany (M.V.T.); and Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs-Institute, University of Würzburg, Würzburg, Germany (T.D.M., H.K.).
Meyer MJ; Institute of Anatomy and Cell Biology, University of Würzburg, Würzburg, Germany (V.G.,S.R. C.M.A., U.R. H.K.); Institute of Clinical Pharmacology, University Medical Center, Georg-August University, Göttingen, Germany (M.J.M., M.V.T.); Institute of Pharmacology, Center of Drug Absorption and Transport, University Medical Center Greifswald, Greifswald, Germany (M.V.T.); and Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs-Institute, University of Würzburg, Würzburg, Germany (T.D.M., H.K.).
Tzvetkov MV; Institute of Anatomy and Cell Biology, University of Würzburg, Würzburg, Germany (V.G.,S.R. C.M.A., U.R. H.K.); Institute of Clinical Pharmacology, University Medical Center, Georg-August University, Göttingen, Germany (M.J.M., M.V.T.); Institute of Pharmacology, Center of Drug Absorption and Transport, University Medical Center Greifswald, Greifswald, Germany (M.V.T.); and Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs-Institute, University of Würzburg, Würzburg, Germany (T.D.M., H.K.).
Mueller TD; Institute of Anatomy and Cell Biology, University of Würzburg, Würzburg, Germany (V.G.,S.R. C.M.A., U.R. H.K.); Institute of Clinical Pharmacology, University Medical Center, Georg-August University, Göttingen, Germany (M.J.M., M.V.T.); Institute of Pharmacology, Center of Drug Absorption and Transport, University Medical Center Greifswald, Greifswald, Germany (M.V.T.); and Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs-Institute, University of Würzburg, Würzburg, Germany (T.D.M., H.K.).
Koepsell H; Institute of Anatomy and Cell Biology, University of Würzburg, Würzburg, Germany (V.G.,S.R. C.M.A., U.R. H.K.); Institute of Clinical Pharmacology, University Medical Center, Georg-August University, Göttingen, Germany (M.J.M., M.V.T.); Institute of Pharmacology, Center of Drug Absorption and Transport, University Medical Center Greifswald, Greifswald, Germany (M.V.T.); and Department of Molecular Plant Physiology and Biophysics, Julius-von-Sachs-Institute, University of Würzburg, Würzburg, Germany (T.D.M., H.K.) .
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Źródło :
Molecular pharmacology [Mol Pharmacol] 2018 Apr; Vol. 93 (4), pp. 402-415. Date of Electronic Publication: 2018 Jan 16.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Catecholamine Plasma Membrane Transport Proteins/*antagonists & inhibitors
Catecholamine Plasma Membrane Transport Proteins/*metabolism
Mutagenesis/*drug effects
1-Methyl-4-phenylpyridinium/metabolism ; 1-Methyl-4-phenylpyridinium/pharmacology ; Animals ; Dose-Response Relationship, Drug ; Female ; HEK293 Cells ; Humans ; Mutagenesis/physiology ; Quaternary Ammonium Compounds/metabolism ; Quaternary Ammonium Compounds/pharmacology ; Rats ; Substrate Specificity/drug effects ; Substrate Specificity/physiology ; Xenopus laevis
Czasopismo naukowe
Tytuł :
Atorvastatin modulates drug transporters and ameliorates nicotine-induced testicular toxicity.
Autorzy :
Syam Das S; Department of Biochemistry, University of Kerala, Thiruvananthapuram, Kerala, India.
Nair SS; Department of Biochemistry, University of Kerala, Thiruvananthapuram, Kerala, India.
Indira M; Department of Biochemistry, University of Kerala, Thiruvananthapuram, Kerala, India.
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Źródło :
Andrologia [Andrologia] 2018 Aug; Vol. 50 (6), pp. e13029. Date of Electronic Publication: 2018 May 08.
Typ publikacji :
Journal Article
MeSH Terms :
Blood-Testis Barrier*/drug effects
Blood-Testis Barrier*/metabolism
Testis*/drug effects
Testis*/metabolism
ATP Binding Cassette Transporter, Subfamily B/*metabolism
Atorvastatin/*pharmacology
Catecholamine Plasma Membrane Transport Proteins/*metabolism
Nicotine/*antagonists & inhibitors
Animals ; Male ; Nicotine/toxicity ; Rats ; Rats, Sprague-Dawley ; Solute Carrier Proteins/metabolism
Czasopismo naukowe
Tytuł :
Catecholaminergic A1/C1 neurons contribute to the maintenance of upper airway muscle tone but may not participate in NREM sleep-related depression of these muscles.
Autorzy :
Rukhadze I; Department of Veterans Affairs, Greater Los Angeles Healthcare System, Los Angeles, CA, USA; Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA; Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA. Electronic address: .
Carballo NJ; Department of Veterans Affairs, Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
Bandaru SS; Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Malhotra A; Division of Pulmonary, Critical Care and Sleep Medicine, University of California San Diego, La Jolla, CA, USA.
Fuller PM; Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA.
Fenik VB; Department of Veterans Affairs, Greater Los Angeles Healthcare System, Los Angeles, CA, USA; WebSience International, Los Angeles, CA, USA.
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Źródło :
Respiratory physiology & neurobiology [Respir Physiol Neurobiol] 2017 Oct; Vol. 244, pp. 41-50. Date of Electronic Publication: 2017 Jul 12.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Catecholamines/*metabolism
Hypoglossal Nerve/*physiology
Medulla Oblongata/*physiology
Respiratory Muscles/*physiology
Sleep Stages/*physiology
Wakefulness/*physiology
Animals ; Electroencephalography ; Electromyography ; Male ; Mice, Inbred C57BL ; Mice, Transgenic ; Motor Neurons/physiology ; Neck Muscles/innervation ; Neck Muscles/physiology ; Neural Pathways/physiology ; Receptors, Catecholamine/genetics ; Receptors, Catecholamine/metabolism ; Respiratory Muscles/innervation
Czasopismo naukowe

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