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Tytuł :
Split Locations and Secondary Structures of a DNAzyme Critical to Binding-Assembled Multicomponent Nucleic Acid Enzymes for Protein Detection.
Autorzy :
Cao Y; Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta T6G 2G3, Canada.
Zhang H; Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta T6G 2G3, Canada.
Le XC; Division of Analytical and Environmental Toxicology, Department of Laboratory Medicine and Pathology, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta T6G 2G3, Canada.
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Źródło :
Analytical chemistry [Anal Chem] 2021 Nov 30; Vol. 93 (47), pp. 15712-15719. Date of Electronic Publication: 2021 Nov 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA, Catalytic*/metabolism
Catalytic Domain ; DNA ; Proteins ; RNA
Czasopismo naukowe
Tytuł :
Synthesis of Oligoribonucleotides Containing a 2'-Amino-5'- S -phosphorothiolate Linkage.
Autorzy :
Li NS; Department of Biochemistry & Molecular Biology, University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, Unites States.
Koo SC; Department of Biochemistry & Molecular Biology, University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, Unites States.
Piccirilli JA; Department of Biochemistry & Molecular Biology, University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, Unites States.; Department of Chemistry, University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, Unites States.
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Źródło :
The Journal of organic chemistry [J Org Chem] 2021 Oct 01; Vol. 86 (19), pp. 13231-13244. Date of Electronic Publication: 2021 Sep 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Oligoribonucleotides*
RNA, Catalytic*/metabolism
Catalytic Domain ; Hepatitis Delta Virus/genetics ; Hepatitis Delta Virus/metabolism ; RNA
Czasopismo naukowe
Tytuł :
Beyond the Plateau: pL Dependence of Proton Inventories as a Tool for Studying Ribozyme and Ribonuclease Catalysis.
Autorzy :
Yoon S; Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200, United States.
Harris ME; Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200, United States.
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Źródło :
Biochemistry [Biochemistry] 2021 Sep 21; Vol. 60 (37), pp. 2810-2823. Date of Electronic Publication: 2021 Sep 08.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Acid-Base Equilibrium/*physiology
RNA, Catalytic/*metabolism
Ribonucleases/*metabolism
Catalysis ; Catalytic Domain ; Hepatitis Delta Virus/enzymology ; Hydrogen-Ion Concentration ; Kinetics ; Nucleic Acid Conformation ; Protons ; RNA, Catalytic/chemistry ; Ribonucleases/chemistry ; Solvents
Czasopismo naukowe
Tytuł :
Witnessing the structural evolution of an RNA enzyme.
Autorzy :
Portillo X; Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, United States.
Huang YT; The Salk Institute, La Jolla, United States.
Breaker RR; Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, United States.; Howard Hughes Medical Institute, New Haven, United States.
Horning DP; The Salk Institute, La Jolla, United States.
Joyce GF; The Salk Institute, La Jolla, United States.
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Źródło :
ELife [Elife] 2021 Sep 09; Vol. 10. Date of Electronic Publication: 2021 Sep 09.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Directed Molecular Evolution*
Evolution, Molecular*
DNA-Directed RNA Polymerases/*metabolism
RNA, Catalytic/*metabolism
Catalysis ; Catalytic Domain ; DNA-Directed RNA Polymerases/chemistry ; DNA-Directed RNA Polymerases/genetics ; Mutation ; Nucleic Acid Conformation ; Phylogeny ; Protein Conformation ; RNA, Catalytic/chemistry ; RNA, Catalytic/genetics ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
The Dynamic Network of RNP RNase P Subunits.
Autorzy :
Shaukat AN; Department of Biochemistry, School of Medicine, University of Patras, 26504 Patras, Greece.
Kaliatsi EG; Department of Biochemistry, School of Medicine, University of Patras, 26504 Patras, Greece.
Skeparnias I; Department of Biochemistry, School of Medicine, University of Patras, 26504 Patras, Greece.
Stathopoulos C; Department of Biochemistry, School of Medicine, University of Patras, 26504 Patras, Greece.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Sep 24; Vol. 22 (19). Date of Electronic Publication: 2021 Sep 24.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Catalytic Domain/*physiology
Protein Subunits/*metabolism
Ribonuclease P/*metabolism
Animals ; Humans ; Kinetics ; RNA Precursors/metabolism ; RNA, Catalytic/metabolism
Czasopismo naukowe
Tytuł :
Is Disrupted Nucleotide-Substrate Cooperativity a Common Trait for Cushing's Syndrome Driving Mutations of Protein Kinase A?
Autorzy :
Walker C; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Wang Y; Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA; Institute of Systems and Physical Biology, Shenzhen Bay Laboratory, Shenzhen 518055, China.
Olivieri C; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
V S M; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Gao J; Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA; Institute of Systems and Physical Biology, Shenzhen Bay Laboratory, Shenzhen 518055, China.
Bernlohr DA; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Calebiro D; Institute of Metabolism and Systems Research, University of Birmingham, B15 2TT Birmingham, UK; Centre of Membrane Proteins and Receptors, Universities of Birmingham and Nottingham, B15 2TT Birmingham, UK.
Taylor SS; Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, CA 92093, USA; Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093, USA.
Veglia G; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA; Department of Chemistry, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: .
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Źródło :
Journal of molecular biology [J Mol Biol] 2021 Sep 03; Vol. 433 (18), pp. 167123. Date of Electronic Publication: 2021 Jul 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Mutation*
Cushing Syndrome/*pathology
Cyclic AMP-Dependent Protein Kinase Catalytic Subunits/*genetics
Cyclic AMP-Dependent Protein Kinases/*metabolism
Nucleotides/*metabolism
Allosteric Regulation ; Catalytic Domain ; Cushing Syndrome/genetics ; Cushing Syndrome/metabolism ; Cyclic AMP-Dependent Protein Kinases/chemistry ; Cyclic AMP-Dependent Protein Kinases/genetics ; Humans ; Nucleotides/chemistry ; Nucleotides/genetics ; Phenotype ; Phosphorylation ; Protein Conformation ; Substrate Specificity
Czasopismo naukowe
Tytuł :
PKA Cβ: a forgotten catalytic subunit of cAMP-dependent protein kinase opens new windows for PKA signaling and disease pathologies.
Autorzy :
Taylor SS; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, U.S.A.; Department of Pharmacology, University of California, San Diego, La Jolla, CA, U.S.A.
Wallbott M; Department of Biochemistry, Institute for Biology, University of Kassel, Kassel, Germany.
Machal EMF; Department of Biochemistry, Institute for Biology, University of Kassel, Kassel, Germany.
Søberg K; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.
Ahmed F; Department of Kinesiology, North Carolina A&T State University, Greensboro, NC, U.S.A.
Bruystens J; Department of Pharmacology, University of California, San Diego, La Jolla, CA, U.S.A.
Vu L; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, U.S.A.
Baker B; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, U.S.A.
Wu J; Department of Pharmacology, University of California, San Diego, La Jolla, CA, U.S.A.
Raimondi F; Laboratorio di Biologia Bio@SNS, Scuola Normale Superiore, Pisa, Italy.
Ongeri EM; Department of Kinesiology, North Carolina A&T State University, Greensboro, NC, U.S.A.
Herberg FW; Department of Biochemistry, Institute for Biology, University of Kassel, Kassel, Germany.
Skålhegg BS; Division for Molecular Nutrition, Institute for Basic Medical Sciences, University of Oslo, Oslo, Norway.
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Źródło :
The Biochemical journal [Biochem J] 2021 Jun 11; Vol. 478 (11), pp. 2101-2119.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Mutation*
Cyclic AMP-Dependent Protein Kinase Catalytic Subunits/*chemistry
Cyclic AMP-Dependent Protein Kinase Catalytic Subunits/*metabolism
Neoplasms/*pathology
Amino Acid Sequence ; Animals ; Catalytic Domain ; Cyclic AMP-Dependent Protein Kinase Catalytic Subunits/genetics ; Exons ; Humans ; Neoplasms/enzymology ; Neoplasms/genetics ; Sequence Homology ; Signal Transduction
Czasopismo naukowe
Tytuł :
RNA-Cleaving NAzymes: The Next Big Thing in Biosensing?
Autorzy :
Safdar S; Department of Biosystems, Biosensors Group, KU Leuven, 3001, Leuven, Belgium.
Lammertyn J; Department of Biosystems, Biosensors Group, KU Leuven, 3001, Leuven, Belgium. Electronic address: .
Spasic D; Department of Biosystems, Biosensors Group, KU Leuven, 3001, Leuven, Belgium.
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Źródło :
Trends in biotechnology [Trends Biotechnol] 2020 Dec; Vol. 38 (12), pp. 1343-1359. Date of Electronic Publication: 2020 May 27.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms :
Biosensing Techniques*/trends
DNA, Catalytic*/metabolism
RNA/metabolism ; RNA, Catalytic/metabolism
Czasopismo naukowe
Tytuł :
Target DNA- and pH-responsive DNA hydrogel-based capillary assay for the optical detection of short SARS-CoV-2 cDNA.
Autorzy :
Jeong JY; Department of Biochemistry, Yeungnam University, 280 Daehak-ro, Gyeongsan-si, Gyeongsangbuk-do, 38541, Republic of Korea.
Do JY; Department of Biochemistry, Yeungnam University, 280 Daehak-ro, Gyeongsan-si, Gyeongsangbuk-do, 38541, Republic of Korea.
Hong CA; Department of Biochemistry, Yeungnam University, 280 Daehak-ro, Gyeongsan-si, Gyeongsangbuk-do, 38541, Republic of Korea. .
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Źródło :
Mikrochimica acta [Mikrochim Acta] 2021 Dec 23; Vol. 189 (1), pp. 34. Date of Electronic Publication: 2021 Dec 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chemistry Techniques, Analytical/*methods
DNA, Catalytic/*chemistry
DNA, Complementary/*analysis
Hydrogels/*chemistry
RNA, Viral/*genetics
SARS-CoV-2/*chemistry
Capillary Action ; Chemistry Techniques, Analytical/instrumentation ; DNA, Catalytic/genetics ; DNA, Complementary/genetics ; Hydrogen-Ion Concentration ; Inverted Repeat Sequences ; Limit of Detection ; Nucleic Acid Amplification Techniques ; Nucleic Acid Hybridization
Czasopismo naukowe
Tytuł :
Multiply-amplified strategy for the ultrasensitive detection of kanamycin via aptamer-triggered three-dimensional G-quadruplex/Ni-Fe layered double oxide frame networks.
Autorzy :
Yao Y; School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang, 212003, Jiangsu Province, PR China.
Hu T; School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang, 212003, Jiangsu Province, PR China.
Song C; School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang, 212003, Jiangsu Province, PR China.
Liu C; School of Grain Science and Technology, Jiangsu University of Science and Technology, Zhenjiang, 212003, Jiangsu Province, PR China. Electronic address: .
Kong D; School of Grain Science and Technology, Jiangsu University of Science and Technology, Zhenjiang, 212003, Jiangsu Province, PR China.
Huang C; School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang, 212003, Jiangsu Province, PR China.
Zhu J; School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang, 212003, Jiangsu Province, PR China.
Shen W; School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang, 212003, Jiangsu Province, PR China. Electronic address: .
Shi H; Jiangsu Institute for Food and Drug Control, Nanjing, 210019, Jiangsu Province, PR China; Key Laboratory for Impurity Profile of Chemical Drugs, National Medical Products Administration, Nanjing, 210019, Jiangsu Province, PR China.
Tang S; School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang, 212003, Jiangsu Province, PR China. Electronic address: .
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Źródło :
Analytica chimica acta [Anal Chim Acta] 2021 Dec 01; Vol. 1187, pp. 339169. Date of Electronic Publication: 2021 Oct 15.
Typ publikacji :
Journal Article
MeSH Terms :
Aptamers, Nucleotide*
Biosensing Techniques*
DNA, Catalytic*/metabolism
G-Quadruplexes*
Colorimetry ; Kanamycin ; Limit of Detection ; Oxides
Czasopismo naukowe
Tytuł :
Virus-associated ribozymes and nano carriers against COVID-19.
Autorzy :
Dönmüş B; Molecular Biology and Genetics Department, Yıldız Technical University, Istanbul, Turkey.
Ünal S; Molecular Biology and Genetics Department, Yıldız Technical University, Istanbul, Turkey.
Kirmizitaş FC; Molecular Biology and Genetics Department, Yıldız Technical University, Istanbul, Turkey.
Türkoğlu Laçin N; Molecular Biology and Genetics Department, Yıldız Technical University, Istanbul, Turkey.
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Źródło :
Artificial cells, nanomedicine, and biotechnology [Artif Cells Nanomed Biotechnol] 2021 Dec; Vol. 49 (1), pp. 204-218.
Typ publikacji :
Journal Article; Review
MeSH Terms :
COVID-19/*drug therapy
Nanoparticles/*administration & dosage
RNA, Catalytic/*therapeutic use
RNA, Viral/*antagonists & inhibitors
SARS-CoV-2/*drug effects
Angiotensin-Converting Enzyme 2/antagonists & inhibitors ; Clinical Trials as Topic ; Drug Carriers ; Drug Compounding ; Drug Design ; HIV Infections/drug therapy ; HIV-1/drug effects ; HIV-1/genetics ; Humans ; Middle East Respiratory Syndrome Coronavirus/drug effects ; Middle East Respiratory Syndrome Coronavirus/genetics ; Models, Molecular ; Nucleic Acid Conformation ; RNA Interference ; RNA, Catalytic/administration & dosage ; RNA, Catalytic/chemistry ; RNA, Catalytic/classification ; RNA, Untranslated/classification ; RNA, Untranslated/genetics ; RNA, Untranslated/therapeutic use ; Receptors, Coronavirus/antagonists & inhibitors ; SARS Virus/drug effects ; SARS Virus/genetics ; SARS-CoV-2/genetics ; SARS-CoV-2/physiology ; Spike Glycoprotein, Coronavirus/physiology ; Virus Replication/drug effects
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Seq2Enz: An application of mask BLAST methodology with a new chemical logic of amino acids for improved enzyme function prediction.
Autorzy :
Pathak A; Department of Chemistry, Indian Institute of Technology, Hauz Khas, New Delhi 110016, India; Supercomputing Facility for Bioinformatics & Computational Biology, Indian Institute of Technology, Hauz Khas, New Delhi 110016, India.
Jayaram B; Department of Chemistry, Indian Institute of Technology, Hauz Khas, New Delhi 110016, India; Supercomputing Facility for Bioinformatics & Computational Biology, Indian Institute of Technology, Hauz Khas, New Delhi 110016, India; Kusuma School of Biological Sciences, Indian Institute of Technology, Hauz Khas, New Delhi 110016, India. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Proteins and proteomics [Biochim Biophys Acta Proteins Proteom] 2022 Jan; Vol. 1870 (1), pp. 140721. Date of Electronic Publication: 2021 Oct 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Catalytic Domain*
Software*
Sequence Analysis, Protein/*methods
Animals ; Enzymes/chemistry ; Enzymes/metabolism ; Humans
Czasopismo naukowe
Tytuł :
G-quadruplex DNAzyme as peroxidase mimetic in a colorimetric biosensor for ultrasensitive and selective detection of trace tetracyclines in foods.
Autorzy :
Tang Y; School of Liquor and Food Engineering, Guizhou Province Key Laboratory of Fermentation Engineering and Biopharmacy; Key Laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region (Ministry of Education), Guizhou University, Huaxi District, Guiyang 550025, China.
Huang X; Comprehensive Technology Center of Guiyang Customs District, Qianlingshan Road 268, Guanshanhu District, Guiyang 550081, China.
Wang X; School of Liquor and Food Engineering, Guizhou Province Key Laboratory of Fermentation Engineering and Biopharmacy; Key Laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region (Ministry of Education), Guizhou University, Huaxi District, Guiyang 550025, China.
Wang C; School of Liquor and Food Engineering, Guizhou Province Key Laboratory of Fermentation Engineering and Biopharmacy; Key Laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region (Ministry of Education), Guizhou University, Huaxi District, Guiyang 550025, China.
Tao H; School of Liquor and Food Engineering, Guizhou Province Key Laboratory of Fermentation Engineering and Biopharmacy; Key Laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region (Ministry of Education), Guizhou University, Huaxi District, Guiyang 550025, China.
Wu Y; School of Liquor and Food Engineering, Guizhou Province Key Laboratory of Fermentation Engineering and Biopharmacy; Key Laboratory of Plant Resource Conservation and Germplasm Innovation in Mountainous Region (Ministry of Education), Guizhou University, Huaxi District, Guiyang 550025, China.. Electronic address: .
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Źródło :
Food chemistry [Food Chem] 2022 Jan 01; Vol. 366, pp. 130560. Date of Electronic Publication: 2021 Jul 09.
Typ publikacji :
Journal Article
MeSH Terms :
Biosensing Techniques*
DNA, Catalytic*
Tetracyclines/*analysis
Anti-Bacterial Agents ; Colorimetry ; G-Quadruplexes ; Hemin ; Peroxidase ; Peroxidases
Czasopismo naukowe
Tytuł :
Binding interactions in a kinase active site modulate background ATP hydrolysis.
Autorzy :
Wang Y; Department of Chemistry, McGill University, 801 Sherbrooke St. W., Montreal, Quebec H3A 0B8, Canada.
Hanrahan G; Department of Chemistry, McGill University, 801 Sherbrooke St. W., Montreal, Quebec H3A 0B8, Canada.
Azar FA; Department of Chemistry, McGill University, 801 Sherbrooke St. W., Montreal, Quebec H3A 0B8, Canada.
Mittermaier A; Department of Chemistry, McGill University, 801 Sherbrooke St. W., Montreal, Quebec H3A 0B8, Canada. Electronic address: .
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Źródło :
Biochimica et biophysica acta. Proteins and proteomics [Biochim Biophys Acta Proteins Proteom] 2022 Jan; Vol. 1870 (1), pp. 140720. Date of Electronic Publication: 2021 Sep 28.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Catalytic Domain*
Adenosine Triphosphate/*metabolism
Kanamycin Kinase/*metabolism
Allosteric Regulation ; Aminoglycosides/metabolism ; Hydrolysis ; Kanamycin Kinase/chemistry ; Kinetics ; Protein Binding
Czasopismo naukowe
Tytuł :
Crystal structure of a novel putative sugar isomerase from the psychrophilic bacterium Paenibacillus sp. R4.
Autorzy :
Kwon S; Department of Biotechnology, Konkuk University, Chungju, Chungbuk, 27478, Republic of Korea.
Ha HJ; College of Pharmacy, Chung-Ang University, Dongjak-gu, Seoul, 06974, Republic of Korea.
Kang YJ; College of Pharmacy, Chung-Ang University, Dongjak-gu, Seoul, 06974, Republic of Korea.
Sung JH; College of Pharmacy, Chung-Ang University, Dongjak-gu, Seoul, 06974, Republic of Korea.
Hwang J; Research Unit of Cryogenic Novel Material, Korea Polar Research Institute, Incheon, 21990, Republic of Korea; Department of Polar Sciences, University of Science and Technology, Incheon, 21990, Republic of Korea.
Lee MJ; Research Unit of Cryogenic Novel Material, Korea Polar Research Institute, Incheon, 21990, Republic of Korea.
Lee JH; Research Unit of Cryogenic Novel Material, Korea Polar Research Institute, Incheon, 21990, Republic of Korea; Department of Polar Sciences, University of Science and Technology, Incheon, 21990, Republic of Korea. Electronic address: .
Park HH; College of Pharmacy, Chung-Ang University, Dongjak-gu, Seoul, 06974, Republic of Korea. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Dec 31; Vol. 585, pp. 48-54. Date of Electronic Publication: 2021 Nov 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Catalytic Domain*
Protein Conformation*
Bacterial Proteins/*chemistry
Paenibacillus/*enzymology
Triose-Phosphate Isomerase/*chemistry
Amino Acids/genetics ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Binding Sites/genetics ; Crystallography, X-Ray ; Metals/chemistry ; Metals/metabolism ; Models, Molecular ; Paenibacillus/genetics ; Triose-Phosphate Isomerase/genetics ; Triose-Phosphate Isomerase/metabolism
Czasopismo naukowe
Tytuł :
Self-Protected DNAzyme Walker with a Circular Bulging DNA Shield for Amplified Imaging of miRNAs in Living Cells and Mice.
Autorzy :
Gao Y; Cancer Metastasis Alert and Prevention Center, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350002, China.
Zhang S; Cancer Metastasis Alert and Prevention Center, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350002, China.; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.; College of Chemistry and Materials Engineering, Hunan University of Arts and Science, Changde 415000, China.
Wu C; Key Laboratory of Laboratory Medicine, Ministry of Education of China, and Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, 325035, China.
Li Q; Cancer Metastasis Alert and Prevention Center, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350002, China.
Shen Z; Key Laboratory of Laboratory Medicine, Ministry of Education of China, and Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, 325035, China.
Lu Y; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.
Wu ZS; Cancer Metastasis Alert and Prevention Center, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, 350002, China.
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Źródło :
ACS nano [ACS Nano] 2021 Dec 28; Vol. 15 (12), pp. 19211-19224. Date of Electronic Publication: 2021 Dec 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biosensing Techniques*
DNA, Catalytic*/metabolism
Metal Nanoparticles*
MicroRNAs*/genetics
Animals ; DNA, Circular ; Gold ; Mice
Czasopismo naukowe
Tytuł :
Construction of a Degradation-Free DNA Conjugated Nanoprobe and Its Application in Rapid Field Screening for Sulfur Mustard.
Autorzy :
Sun J; Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Prevention and Control, Beijing 100013, China.
Li C; Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
Shan W; College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Wei Y; Department of Biomaterials Science and Technology, MIRA Institute for Biological Technology and Technical Medicine, University of Twente, Enschede 7500AE, Netherlands.
Liu R; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
Li H; Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Prevention and Control, Beijing 100013, China.
Cao D; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
Guo Q; Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Prevention and Control, Beijing 100013, China.
Zhao H; State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
Liu R; School of Public Health, Capital Medical University, Beijing 100069, China.
Shao B; Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Prevention and Control, Beijing 100013, China.; College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.; School of Public Health, Capital Medical University, Beijing 100069, China.
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Źródło :
Analytical chemistry [Anal Chem] 2021 Dec 21; Vol. 93 (50), pp. 16735-16740. Date of Electronic Publication: 2021 Dec 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA, Catalytic*
G-Quadruplexes*
Mustard Gas*/toxicity
Hemin ; Research
Czasopismo naukowe
Tytuł :
Caught in motion: human NTHL1 undergoes interdomain rearrangement necessary for catalysis.
Autorzy :
Carroll BL; Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405, USA.
Zahn KE; Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405, USA.
Hanley JP; Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405, USA.
Wallace SS; Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405, USA.
Dragon JA; Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405, USA.
Doublié S; Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Dec 16; Vol. 49 (22), pp. 13165-13178.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Catalytic Domain*
DNA Repair*
Protein Domains*
DNA/*chemistry
Deoxyribonuclease (Pyrimidine Dimer)/*chemistry
Amino Acid Sequence ; Biocatalysis ; DNA/genetics ; DNA/metabolism ; Deoxyribonuclease (Pyrimidine Dimer)/genetics ; Deoxyribonuclease (Pyrimidine Dimer)/metabolism ; Humans ; Models, Molecular ; Mutation ; Nucleic Acid Conformation ; Protein Binding ; Protein Conformation ; Pyrimidines/metabolism ; Sequence Homology, Amino Acid
Czasopismo naukowe
Tytuł :
Zippered G-quadruplex/hemin DNAzyme: exceptional catalyst for universal bioanalytical applications.
Autorzy :
Li J; The Center for Clinical Molecular Medical detection, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China.; Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, P.R. China.
Wu H; Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, P.R. China.
Yan Y; Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, P.R. China.
Yuan T; Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, P.R. China.
Shu Y; The Center for Clinical Molecular Medical detection, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China.
Gao X; Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, P.R. China.
Zhang L; Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, P.R. China.
Li S; Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, P.R. China.
Ding S; Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), College of Laboratory Medicine, Chongqing Medical University, Chongqing 400016, P.R. China.
Cheng W; The Center for Clinical Molecular Medical detection, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Dec 16; Vol. 49 (22), pp. 13031-13044.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
G-Quadruplexes*
DNA, Catalytic/*metabolism
Enzyme Assays/*methods
Hemin/*metabolism
Biocatalysis ; Cell Line, Tumor ; Circular Dichroism/methods ; DNA, Catalytic/genetics ; Enzyme Stability ; Hemin/chemistry ; Humans ; Hydrogen-Ion Concentration ; Kinetics ; MCF-7 Cells ; Molecular Structure ; Mutation ; Spectrophotometry/methods ; Temperature
Czasopismo naukowe
Tytuł :
DNAzyme based three-way junction assay for antibody-free detection of locus-specific N -methyladenosine modifications.
Autorzy :
Yu H; Key Laboratory of Clinical Laboratory Diagnostics (Chinese Ministry of Education), College of Laboratory Medicine, Chongqing Medical Laboratory Microfluidics and SPRi Engineering Research Center, Chongqing Medical University, No. 1 Yi Xue Yuan Road, Chongqing, 400016, PR China.
Pu Q; Key Laboratory of Clinical Laboratory Diagnostics (Chinese Ministry of Education), College of Laboratory Medicine, Chongqing Medical Laboratory Microfluidics and SPRi Engineering Research Center, Chongqing Medical University, No. 1 Yi Xue Yuan Road, Chongqing, 400016, PR China; Department of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, PR China.
Weng Z; Key Laboratory of Clinical Laboratory Diagnostics (Chinese Ministry of Education), College of Laboratory Medicine, Chongqing Medical Laboratory Microfluidics and SPRi Engineering Research Center, Chongqing Medical University, No. 1 Yi Xue Yuan Road, Chongqing, 400016, PR China.
Zhou X; Key Laboratory of Clinical Laboratory Diagnostics (Chinese Ministry of Education), College of Laboratory Medicine, Chongqing Medical Laboratory Microfluidics and SPRi Engineering Research Center, Chongqing Medical University, No. 1 Yi Xue Yuan Road, Chongqing, 400016, PR China.
Li J; Key Laboratory of Clinical Laboratory Diagnostics (Chinese Ministry of Education), College of Laboratory Medicine, Chongqing Medical Laboratory Microfluidics and SPRi Engineering Research Center, Chongqing Medical University, No. 1 Yi Xue Yuan Road, Chongqing, 400016, PR China.
Yang Y; Key Laboratory of Clinical Laboratory Diagnostics (Chinese Ministry of Education), College of Laboratory Medicine, Chongqing Medical Laboratory Microfluidics and SPRi Engineering Research Center, Chongqing Medical University, No. 1 Yi Xue Yuan Road, Chongqing, 400016, PR China.
Luo W; Key Laboratory of Clinical Laboratory Diagnostics (Chinese Ministry of Education), College of Laboratory Medicine, Chongqing Medical Laboratory Microfluidics and SPRi Engineering Research Center, Chongqing Medical University, No. 1 Yi Xue Yuan Road, Chongqing, 400016, PR China.
Guo Y; Department of Laboratory Medicine, Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, 646000, China.
Chen H; Key Laboratory of Clinical Laboratory Diagnostics (Chinese Ministry of Education), College of Laboratory Medicine, Chongqing Medical Laboratory Microfluidics and SPRi Engineering Research Center, Chongqing Medical University, No. 1 Yi Xue Yuan Road, Chongqing, 400016, PR China; Chongqing Emergency Medical Center, Chongqing University Central Hospital, School of Medicine, Chongqing University, Chongqing, China.
Wang D; Key Laboratory of Clinical Laboratory Diagnostics (Chinese Ministry of Education), College of Laboratory Medicine, Chongqing Medical Laboratory Microfluidics and SPRi Engineering Research Center, Chongqing Medical University, No. 1 Yi Xue Yuan Road, Chongqing, 400016, PR China; Shanghai Upper Bio Tech Pharma Co.,Ltd., Shanghai, 201201, China.
Xie G; Key Laboratory of Clinical Laboratory Diagnostics (Chinese Ministry of Education), College of Laboratory Medicine, Chongqing Medical Laboratory Microfluidics and SPRi Engineering Research Center, Chongqing Medical University, No. 1 Yi Xue Yuan Road, Chongqing, 400016, PR China. Electronic address: .
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Źródło :
Biosensors & bioelectronics [Biosens Bioelectron] 2021 Dec 15; Vol. 194, pp. 113625. Date of Electronic Publication: 2021 Sep 11.
Typ publikacji :
Journal Article
MeSH Terms :
Biosensing Techniques*
DNA, Catalytic*
Adenosine/analogs & derivatives ; Methylation ; RNA/metabolism
Czasopismo naukowe

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