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Tytuł :
Polysaccharides of vinegar-baked radix bupleuri promote the hepatic targeting effect of oxymatrine by regulating the protein expression of HNF4α, Mrp2, and OCT1.
Autorzy :
Wu Y; Guangdong Provincial Hospital of Chinese Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangdong, 510120, China.
Liu L; Guangdong Provincial Hospital of Chinese Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangdong, 510120, China.
Zhao Y; Guangdong Provincial Hospital of Chinese Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangdong, 510120, China.
Zhao R; Guangdong Provincial Hospital of Chinese Medicine, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangdong, 510120, China; Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, China. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2021 Mar 01; Vol. 267, pp. 113471. Date of Electronic Publication: 2020 Oct 17.
Typ publikacji :
Journal Article
MeSH Terms :
Cooking*
ATP-Binding Cassette Transporters/*metabolism
Acetic Acid/*chemistry
Alkaloids/*pharmacokinetics
Alkaloids/*pharmacology
Catecholamine Plasma Membrane Transport Proteins/*metabolism
Hepatocyte Nuclear Factor 4/*metabolism
Liver/*drug effects
Multidrug Resistance-Associated Proteins/*metabolism
Plant Extracts/*pharmacology
Polysaccharides/*pharmacology
Quinolizines/*pharmacokinetics
Quinolizines/*pharmacology
ATP-Binding Cassette Transporters/genetics ; Animals ; Bupleurum/chemistry ; Catecholamine Plasma Membrane Transport Proteins/genetics ; Gene Expression Regulation ; Hep G2 Cells ; Hepatocyte Nuclear Factor 4/genetics ; Hot Temperature ; Humans ; Liver/metabolism ; Male ; Multidrug Resistance-Associated Proteins/genetics ; Plant Extracts/chemistry ; Polysaccharides/chemistry ; Rats, Sprague-Dawley ; Tissue Distribution
Czasopismo naukowe
Tytuł :
Trospium Chloride Transport by Mouse Drug Carriers of the Slc22 and Slc47 Families.
Autorzy :
Gorecki M; Institute of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Justus Liebig University Giessen, 35392 Giessen, Germany.
Müller SF; Institute of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Justus Liebig University Giessen, 35392 Giessen, Germany.
Leidolf R; Institute of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Justus Liebig University Giessen, 35392 Giessen, Germany.
Geyer J; Institute of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Justus Liebig University Giessen, 35392 Giessen, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Dec 22; Vol. 22 (1). Date of Electronic Publication: 2020 Dec 22.
Typ publikacji :
Journal Article
MeSH Terms :
Benzilates/*metabolism
Catecholamine Plasma Membrane Transport Proteins/*metabolism
Nortropanes/*metabolism
Organic Cation Transport Proteins/*metabolism
Organic Cation Transporter 2/*metabolism
Animals ; Benzilates/pharmacokinetics ; Biological Transport ; Catecholamine Plasma Membrane Transport Proteins/genetics ; HEK293 Cells ; Humans ; Kinetics ; Mice, Inbred C57BL ; Mice, Knockout ; Muscarinic Antagonists/metabolism ; Muscarinic Antagonists/pharmacokinetics ; Nortropanes/pharmacokinetics ; Organic Cation Transport Proteins/genetics ; Organic Cation Transporter 2/genetics
Czasopismo naukowe
Tytuł :
Functional and Pharmacological Comparison of Human, Mouse, and Rat Organic Cation Transporter 1 toward Drug and Pesticide Interaction.
Autorzy :
Floerl S; PortaCellTec Biosciences GmbH, 37075 Goettingen, Germany.
Kuehne A; PortaCellTec Biosciences GmbH, 37075 Goettingen, Germany.
Hagos Y; PortaCellTec Biosciences GmbH, 37075 Goettingen, Germany.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Sep 19; Vol. 21 (18). Date of Electronic Publication: 2020 Sep 19.
Typ publikacji :
Journal Article
MeSH Terms :
Catecholamine Plasma Membrane Transport Proteins/*metabolism
Clonidine/*pharmacology
Fungicides, Industrial/*pharmacology
Verapamil/*pharmacology
Animals ; Catecholamine Plasma Membrane Transport Proteins/antagonists & inhibitors ; Catecholamine Plasma Membrane Transport Proteins/genetics ; Drug Interactions ; HEK293 Cells ; Humans ; Mice ; Rats ; Species Specificity
Czasopismo naukowe
Tytuł :
Metabolic Acidosis Alters Expression of Slc22 Transporters in Mouse Kidney.
Autorzy :
Gottier Nwafor J; Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland.
Nowik M; Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland.
Anzai N; Department of Pharmacology, Chiba University Graduate School of Medicine, Chiba, Japan.
Endou H; Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Japan.
Wagner CA; Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland, .
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Źródło :
Kidney & blood pressure research [Kidney Blood Press Res] 2020; Vol. 45 (2), pp. 263-274. Date of Electronic Publication: 2020 Feb 14.
Typ publikacji :
Journal Article
MeSH Terms :
Acidosis/*metabolism
Catecholamine Plasma Membrane Transport Proteins/*biosynthesis
Kidney Diseases/*pathology
Acidosis/blood ; Acidosis/pathology ; Acidosis/urine ; Animals ; Catecholamine Plasma Membrane Transport Proteins/genetics ; Catecholamine Plasma Membrane Transport Proteins/metabolism ; Kidney Diseases/blood ; Kidney Diseases/metabolism ; Kidney Diseases/urine ; Male ; Mice ; Mice, Inbred C57BL ; Octamer Transcription Factor-1/biosynthesis ; Octamer Transcription Factor-1/genetics ; Octamer Transcription Factor-1/metabolism ; Organic Anion Transporters/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Uric Acid/blood ; Uric Acid/urine
Czasopismo naukowe
Tytuł :
CP-25 improves nephropathy in collagen-induced arthritis rats by inhibiting the renal inflammatory response.
Autorzy :
Wang C; Institute of Clinical Pharmacology, Anhui Medical University, Hefei 230032, China; Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Hefei 230032, China; Anhui Collaborative Innovation Centre of Anti-Inflammatory and Immune Medicine, Hefei 230032, China.
Wei X; Blood Purification Center, First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
Wu Y; Institute of Clinical Pharmacology, Anhui Medical University, Hefei 230032, China; Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Hefei 230032, China; Anhui Collaborative Innovation Centre of Anti-Inflammatory and Immune Medicine, Hefei 230032, China.
Tang H; Institute of Clinical Pharmacology, Anhui Medical University, Hefei 230032, China; Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Hefei 230032, China; Anhui Collaborative Innovation Centre of Anti-Inflammatory and Immune Medicine, Hefei 230032, China.
Wang B; Institute of Clinical Pharmacology, Anhui Medical University, Hefei 230032, China; Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Hefei 230032, China; Anhui Collaborative Innovation Centre of Anti-Inflammatory and Immune Medicine, Hefei 230032, China.
Wang Y; Institute of Clinical Pharmacology, Anhui Medical University, Hefei 230032, China; Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Hefei 230032, China; Anhui Collaborative Innovation Centre of Anti-Inflammatory and Immune Medicine, Hefei 230032, China.
Sun W; Institute of Clinical Pharmacology, Anhui Medical University, Hefei 230032, China; Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Hefei 230032, China; Anhui Collaborative Innovation Centre of Anti-Inflammatory and Immune Medicine, Hefei 230032, China.
Asenso J; Institute of Clinical Pharmacology, Anhui Medical University, Hefei 230032, China; Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Hefei 230032, China; Anhui Collaborative Innovation Centre of Anti-Inflammatory and Immune Medicine, Hefei 230032, China.
Xiao F; Institute of Clinical Pharmacology, Anhui Medical University, Hefei 230032, China; Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Hefei 230032, China; Anhui Collaborative Innovation Centre of Anti-Inflammatory and Immune Medicine, Hefei 230032, China.
Wei W; Institute of Clinical Pharmacology, Anhui Medical University, Hefei 230032, China; Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Hefei 230032, China; Anhui Collaborative Innovation Centre of Anti-Inflammatory and Immune Medicine, Hefei 230032, China. Electronic address: .
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Źródło :
International immunopharmacology [Int Immunopharmacol] 2020 Nov; Vol. 88, pp. 106997. Date of Electronic Publication: 2020 Sep 22.
Typ publikacji :
Journal Article
MeSH Terms :
Arthritis, Experimental/*complications
Glucosides/*therapeutic use
Inflammation/*drug therapy
Kidney Diseases/*chemically induced
Kidney Diseases/*drug therapy
Monoterpenes/*therapeutic use
Animals ; Catecholamine Plasma Membrane Transport Proteins/genetics ; Catecholamine Plasma Membrane Transport Proteins/metabolism ; Gene Expression Regulation/drug effects ; Male ; Organic Anion Transport Protein 1/genetics ; Organic Anion Transport Protein 1/metabolism ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Amphetamine-like Neurochemical and Cardiovascular Effects of α -Ethylphenethylamine Analogs Found in Dietary Supplements.
Autorzy :
Schindler CW; Designer Drug Research Unit (C.W.S., J.S.P., M.H.B.) and Preclinical Pharmacology Section (C.W.S., E.B.T.), National Institute on Drug Abuse Intramural Research Program, Baltimore, Maryland and Drug Design and Synthesis Section, National Institute on Drug Abuse and National Institute of Alcohol Abuse and Alcoholism Intramural Research Programs, Rockville, Maryland (K.C.R.) .
Thorndike EB; Designer Drug Research Unit (C.W.S., J.S.P., M.H.B.) and Preclinical Pharmacology Section (C.W.S., E.B.T.), National Institute on Drug Abuse Intramural Research Program, Baltimore, Maryland and Drug Design and Synthesis Section, National Institute on Drug Abuse and National Institute of Alcohol Abuse and Alcoholism Intramural Research Programs, Rockville, Maryland (K.C.R.).
Partilla JS; Designer Drug Research Unit (C.W.S., J.S.P., M.H.B.) and Preclinical Pharmacology Section (C.W.S., E.B.T.), National Institute on Drug Abuse Intramural Research Program, Baltimore, Maryland and Drug Design and Synthesis Section, National Institute on Drug Abuse and National Institute of Alcohol Abuse and Alcoholism Intramural Research Programs, Rockville, Maryland (K.C.R.).
Rice KC; Designer Drug Research Unit (C.W.S., J.S.P., M.H.B.) and Preclinical Pharmacology Section (C.W.S., E.B.T.), National Institute on Drug Abuse Intramural Research Program, Baltimore, Maryland and Drug Design and Synthesis Section, National Institute on Drug Abuse and National Institute of Alcohol Abuse and Alcoholism Intramural Research Programs, Rockville, Maryland (K.C.R.).
Baumann MH; Designer Drug Research Unit (C.W.S., J.S.P., M.H.B.) and Preclinical Pharmacology Section (C.W.S., E.B.T.), National Institute on Drug Abuse Intramural Research Program, Baltimore, Maryland and Drug Design and Synthesis Section, National Institute on Drug Abuse and National Institute of Alcohol Abuse and Alcoholism Intramural Research Programs, Rockville, Maryland (K.C.R.).
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Źródło :
The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2021 Jan; Vol. 376 (1), pp. 118-126. Date of Electronic Publication: 2020 Oct 20.
Typ publikacji :
Journal Article; Research Support, N.I.H., Intramural
MeSH Terms :
Blood Pressure/*drug effects
Butylamines/*pharmacology
Central Nervous System Stimulants/*pharmacology
Heart Rate/*drug effects
Methamphetamine/*analogs & derivatives
Movement/*drug effects
Phenethylamines/*pharmacology
Animals ; Catecholamine Plasma Membrane Transport Proteins/metabolism ; Dietary Supplements/adverse effects ; Dopamine Plasma Membrane Transport Proteins/metabolism ; Dose-Response Relationship, Drug ; Male ; Methamphetamine/pharmacology ; Norepinephrine Plasma Membrane Transport Proteins/metabolism ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Organic cation transporter and multidrug and toxin extrusion 1 co-mediated interaction between metformin and berberine.
Autorzy :
Shi R; Department of Pharmacology, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Xu Z; Department of Pharmacology, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Xu X; Department of Pharmacology, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Jin J; Department of Pharmacology, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Zhao Y; Department of Pharmacology, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Wang T; Department of Pharmacology, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Li Y; Department of Pharmacology, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Ma Y; Department of Pharmacology, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Electronic address: .
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Źródło :
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2019 Jan 15; Vol. 127, pp. 282-290. Date of Electronic Publication: 2018 Nov 11.
Typ publikacji :
Journal Article
MeSH Terms :
Antiporters/*metabolism
Berberine/*pharmacokinetics
Catecholamine Plasma Membrane Transport Proteins/*metabolism
Hypoglycemic Agents/*pharmacokinetics
Metformin/*pharmacokinetics
Organic Cation Transport Proteins/*metabolism
Organic Cation Transporter 2/*metabolism
Adipose Tissue/metabolism ; Animals ; Antiporters/genetics ; Berberine/blood ; Catecholamine Plasma Membrane Transport Proteins/genetics ; Dogs ; Drug Interactions ; Female ; Hypoglycemic Agents/blood ; Intestinal Mucosa/metabolism ; Kidney/metabolism ; Liver/metabolism ; Madin Darby Canine Kidney Cells ; Male ; Metformin/blood ; Muscle, Skeletal/metabolism ; Organic Cation Transport Proteins/genetics ; Organic Cation Transporter 2/genetics ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
The fatty acid amide hydrolase inhibitor URB597 modulates splenic catecholamines in chronically stressed female and male rats.
Autorzy :
Ferizovic H; Department of Molecular Biology and Endocrinology, 'Vinča' Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia.
Spasojevic N; Department of Molecular Biology and Endocrinology, 'Vinča' Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia.
Stefanovic B; Department of Molecular Biology and Endocrinology, 'Vinča' Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia.
Jankovic M; Department of Molecular Biology and Endocrinology, 'Vinča' Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia.
Dronjak S; Department of Molecular Biology and Endocrinology, 'Vinča' Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia. Electronic address: .
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Źródło :
International immunopharmacology [Int Immunopharmacol] 2020 Aug; Vol. 85, pp. 106615. Date of Electronic Publication: 2020 May 21.
Typ publikacji :
Journal Article
MeSH Terms :
Amidohydrolases/*antagonists & inhibitors
Anti-Anxiety Agents/*pharmacology
Benzamides/*pharmacology
Carbamates/*pharmacology
Catecholamines/*metabolism
Spleen/*drug effects
Spleen/*metabolism
Stress, Physiological/*drug effects
Animals ; Anti-Anxiety Agents/therapeutic use ; Anxiety/drug therapy ; Benzamides/therapeutic use ; Carbamates/therapeutic use ; Catechol O-Methyltransferase/metabolism ; Catecholamine Plasma Membrane Transport Proteins/metabolism ; Endocannabinoids/pharmacology ; Female ; Interleukin-10/blood ; Interleukin-6/blood ; Male ; Monoamine Oxidase/metabolism ; Neuroprotective Agents/pharmacology ; Open Field Test/drug effects ; Phenylethanolamine N-Methyltransferase/metabolism ; Rats, Wistar ; Sex Factors ; Spleen/immunology ; Stress, Physiological/physiology
Czasopismo naukowe
Tytuł :
Involvement of CYP2D6 and CYP2B6 on tramadol pharmacokinetics.
Autorzy :
Saiz-Rodríguez M; Clinical Pharmacology Department, Hospital Universitario de La Princesa, Instituto Teófilo Hernando, Universidad Autónoma de Madrid (UAM), Instituto de Investigación Sanitaria La Princesa (IP), Madrid, 28006, Spain.
Ochoa D; Clinical Pharmacology Department, Hospital Universitario de La Princesa, Instituto Teófilo Hernando, Universidad Autónoma de Madrid (UAM), Instituto de Investigación Sanitaria La Princesa (IP), Madrid, 28006, Spain.; UICEC Hospital Universitario de La Princesa, Plataforma SCReN (Spanish Clinical Reseach Network), Instituto de Investigación Sanitaria La Princesa (IP), Madrid, 28006, Spain.
Román M; Clinical Pharmacology Department, Hospital Universitario de La Princesa, Instituto Teófilo Hernando, Universidad Autónoma de Madrid (UAM), Instituto de Investigación Sanitaria La Princesa (IP), Madrid, 28006, Spain.; UICEC Hospital Universitario de La Princesa, Plataforma SCReN (Spanish Clinical Reseach Network), Instituto de Investigación Sanitaria La Princesa (IP), Madrid, 28006, Spain.
Zubiaur P; Clinical Pharmacology Department, Hospital Universitario de La Princesa, Instituto Teófilo Hernando, Universidad Autónoma de Madrid (UAM), Instituto de Investigación Sanitaria La Princesa (IP), Madrid, 28006, Spain.
Koller D; Clinical Pharmacology Department, Hospital Universitario de La Princesa, Instituto Teófilo Hernando, Universidad Autónoma de Madrid (UAM), Instituto de Investigación Sanitaria La Princesa (IP), Madrid, 28006, Spain.
Mejía G; Clinical Pharmacology Department, Hospital Universitario de La Princesa, Instituto Teófilo Hernando, Universidad Autónoma de Madrid (UAM), Instituto de Investigación Sanitaria La Princesa (IP), Madrid, 28006, Spain.; UICEC Hospital Universitario de La Princesa, Plataforma SCReN (Spanish Clinical Reseach Network), Instituto de Investigación Sanitaria La Princesa (IP), Madrid, 28006, Spain.
Abad-Santos F; Clinical Pharmacology Department, Hospital Universitario de La Princesa, Instituto Teófilo Hernando, Universidad Autónoma de Madrid (UAM), Instituto de Investigación Sanitaria La Princesa (IP), Madrid, 28006, Spain.; UICEC Hospital Universitario de La Princesa, Plataforma SCReN (Spanish Clinical Reseach Network), Instituto de Investigación Sanitaria La Princesa (IP), Madrid, 28006, Spain.; Pharmacology Department, Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, 28049, Spain.
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Źródło :
Pharmacogenomics [Pharmacogenomics] 2020 Jul; Vol. 21 (10), pp. 663-675. Date of Electronic Publication: 2020 Jun 15.
Typ publikacji :
Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
MeSH Terms :
Analgesics, Opioid/*pharmacokinetics
Cytochrome P-450 CYP2B6/*genetics
Cytochrome P-450 CYP2D6/*genetics
Tramadol/*pharmacokinetics
ATP Binding Cassette Transporter, Subfamily B/genetics ; Catechol O-Methyltransferase/genetics ; Catecholamine Plasma Membrane Transport Proteins/genetics ; Cross-Over Studies ; Cytochrome P-450 CYP3A/genetics ; Female ; Genotype ; Humans ; Male ; Polymorphism, Genetic/genetics ; Receptors, Opioid, mu/genetics
Czasopismo naukowe
Tytuł :
Neuroendocrine Factors in Melanoma Pathogenesis.
Autorzy :
Scheau, Cristian (AUTHOR)
Draghici, Carmen (AUTHOR)
Ilie, Mihaela Adriana (AUTHOR)
Lupu, Mihai (AUTHOR)
Solomon, Iulia (AUTHOR)
Tampa, Mircea (AUTHOR)
Georgescu, Simona Roxana (AUTHOR)
Caruntu, Ana (AUTHOR)
Constantin, Carolina (AUTHOR)
Neagu, Monica (AUTHOR)
Caruntu, Constantin (AUTHOR)
Chen, Suzie (AUTHOR)
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Źródło :
Cancers. May2021, Vol. 13 Issue 9, p2277-2277. 1p.
Czasopismo naukowe
Tytuł :
Pheochromocytoma and paraganglioma with negative results for urinary metanephrines show higher risks for metastatic diseases
Autorzy :
Kawashima, Akiyuki
Sone, MasakatsuAff1, Aff2
Inagaki, Nobuya
Okamoto, Kentaro
Tsuiki, Mika
Izawa, Shoichiro
Otsuki, Michio
Okamura, Shintaro
Ichijo, Takamasa
Katabami, Takuyuki
Takeda, Yoshiyu
Yoshimoto, TakanobuAff10, Aff11
Naruse, Mitsuhide
Tanabe, Akiyo
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Źródło :
Endocrine: International Journal of Basic and Clinical Endocrinology. :1-8
Czasopismo naukowe
Tytuł :
Pharmacological profiles of compounds in preworkout supplements ("boosters").
Autorzy :
Rickli A; Division of Clinical Pharmacology and Toxicology, Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland.
Hoener MC; Neuroscience Research, pRED, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
Liechti ME; Division of Clinical Pharmacology and Toxicology, Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland. Electronic address: .
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2019 Sep 15; Vol. 859, pp. 172515. Date of Electronic Publication: 2019 Jun 29.
Typ publikacji :
Journal Article
MeSH Terms :
Exercise/*physiology
Performance-Enhancing Substances/*pharmacology
Biogenic Monoamines/metabolism ; Biological Transport/drug effects ; Catecholamine Plasma Membrane Transport Proteins/metabolism ; Dietary Supplements ; HEK293 Cells ; Humans ; Performance-Enhancing Substances/metabolism ; Phenethylamines/metabolism ; Phenethylamines/pharmacology
Czasopismo naukowe
Tytuł :
The flight response impairs cytoprotective mechanisms by activating the insulin pathway.
Autorzy :
De Rosa MJ; Instituto de Investigaciones Bioquímicas de Bahía Blanca (CONICET), Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur, Bahía Blanca, Argentina.
Veuthey T; Instituto de Investigaciones Bioquímicas de Bahía Blanca (CONICET), Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur, Bahía Blanca, Argentina.
Florman J; Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA, USA.
Grant J; Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA, USA.
Blanco MG; Instituto de Investigaciones Bioquímicas de Bahía Blanca (CONICET), Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur, Bahía Blanca, Argentina.
Andersen N; Instituto de Investigaciones Bioquímicas de Bahía Blanca (CONICET), Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur, Bahía Blanca, Argentina.
Donnelly J; Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA, USA.
Rayes D; Instituto de Investigaciones Bioquímicas de Bahía Blanca (CONICET), Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur, Bahía Blanca, Argentina. .; Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA, USA. .
Alkema MJ; Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA, USA. .
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Źródło :
Nature [Nature] 2019 Sep; Vol. 573 (7772), pp. 135-138. Date of Electronic Publication: 2019 Aug 28.
Typ publikacji :
Journal Article
MeSH Terms :
Cytoprotection*
Caenorhabditis elegans/*cytology
Caenorhabditis elegans/*physiology
Insulin/*metabolism
Tyramine/*metabolism
Active Transport, Cell Nucleus ; Animals ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/metabolism ; Cell Nucleus/metabolism ; Forkhead Transcription Factors/metabolism ; Insulin-Like Growth Factor I/metabolism ; Intestinal Mucosa/metabolism ; Longevity ; Neurons/metabolism ; Receptors, Adrenergic/metabolism ; Receptors, Catecholamine/metabolism ; Signal Transduction ; Stress, Psychological
Czasopismo naukowe
Tytuł :
Rate-Determining and Rate-Limiting Steps in the Clearance and Excretion of a Potent and Selective p21-Activated Kinase Inhibitor: A Case Study of Rapid Hepatic Uptake and Slow Elimination in Rat.
Autorzy :
Fan PW; Genentech, Inc. 1 DNA Way, MS 412a, South San Francisco, CA 94080, USA. .
Chen JZ
Allan Jaochico M
La H
Liu N
Mulder T
Cass RT
Durk M
Messick K
Valle N
Liu S
Lee W
Crawford JJ
Rudolf J
Murray LJ
Cyrus Khojasteh S
Wright M
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Źródło :
Drug metabolism letters [Drug Metab Lett] 2016; Vol. 10 (2), pp. 91-100.
Typ publikacji :
Journal Article
MeSH Terms :
Catecholamine Plasma Membrane Transport Proteins/*metabolism
Liver/*metabolism
Protein Kinase Inhibitors/*pharmacokinetics
Pyrazoles/*pharmacokinetics
Pyrimidines/*pharmacokinetics
p21-Activated Kinases/*antagonists & inhibitors
Animals ; Catecholamine Plasma Membrane Transport Proteins/genetics ; Female ; Male ; Mice ; Mice, Knockout ; Organic Cation Transport Proteins/metabolism ; Rats ; Rats, Sprague-Dawley ; Triazoles/pharmacology
Czasopismo naukowe
Tytuł :
Interspecies variations in Bordetella catecholamine receptor gene regulation and function.
Autorzy :
Brickman TJ; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Suhadolc RJ; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Armstrong SK; Department of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, Minnesota, USA .
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Źródło :
Infection and immunity [Infect Immun] 2015 Dec; Vol. 83 (12), pp. 4639-52. Date of Electronic Publication: 2015 Sep 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Gene Expression Regulation, Bacterial*
Bacterial Outer Membrane Proteins/*immunology
Bordetella Infections/*immunology
Bordetella bronchiseptica/*pathogenicity
Bordetella pertussis/*pathogenicity
Receptors, Catecholamine/*immunology
Receptors, Cell Surface/*immunology
Animals ; Bacterial Outer Membrane Proteins/genetics ; Bacterial Proteins/genetics ; Bacterial Proteins/immunology ; Bordetella Infections/microbiology ; Bordetella Infections/pathology ; Bordetella bronchiseptica/genetics ; Bordetella bronchiseptica/immunology ; Bordetella bronchiseptica/metabolism ; Bordetella pertussis/genetics ; Bordetella pertussis/immunology ; Bordetella pertussis/metabolism ; Catecholamines/immunology ; Catecholamines/metabolism ; Humans ; Iron/immunology ; Iron/metabolism ; Mice ; Mice, Inbred BALB C ; Protein Isoforms/genetics ; Protein Isoforms/immunology ; Receptors, Catecholamine/genetics ; Receptors, Cell Surface/genetics ; Siderophores/immunology ; Siderophores/metabolism ; Species Specificity ; Transcription Factors/genetics ; Transcription Factors/immunology ; Virulence
Czasopismo naukowe
Tytuł :
Association of serotoninergic pathway gene variants with elite athletic status in the Polish population.
Autorzy :
Peplonska B; a Department of Neurodegenerative Disorders , Mossakowski Medical Research Centre Polish Academy of Sciences , Warsaw , Poland.
Safranow K; b Department of Biochemistry and Medical Chemistry , Pomeranian Medical University , Szczecin , Poland.
Adamczyk J; c Department of Sport's Theory , Jozef Pilsudski University of Physical Education in Warsaw , Warsaw , Poland.
Boguszewski D; d Department of Rehabilitation, Physiotherapy Division , Medical University of Warsaw , Warsaw , Poland.
Szymański K; e Department of Medical Genetics , Centre for Biostructure, Medical University of Warsaw , Warsaw , Poland.
Soltyszewski I; f Department of Criminology and Forensic Medicine , Warmia and Mazury University , Olsztyn , Poland.
Barczak A; a Department of Neurodegenerative Disorders , Mossakowski Medical Research Centre Polish Academy of Sciences , Warsaw , Poland.
Siewierski M; c Department of Sport's Theory , Jozef Pilsudski University of Physical Education in Warsaw , Warsaw , Poland.
Ploski R; e Department of Medical Genetics , Centre for Biostructure, Medical University of Warsaw , Warsaw , Poland.
Sozanski H; c Department of Sport's Theory , Jozef Pilsudski University of Physical Education in Warsaw , Warsaw , Poland.
Zekanowski C; c Department of Sport's Theory , Jozef Pilsudski University of Physical Education in Warsaw , Warsaw , Poland.
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Źródło :
Journal of sports sciences [J Sports Sci] 2019 Jul; Vol. 37 (14), pp. 1655-1662. Date of Electronic Publication: 2019 Mar 05.
Typ publikacji :
Journal Article
MeSH Terms :
Polymorphism, Single Nucleotide*
Athletic Performance/*physiology
Emotions/*physiology
Receptors, Serotonin/*genetics
Adult ; Anxiety/genetics ; DNA-Binding Proteins/genetics ; Female ; Genotype ; Humans ; Hypothalamo-Hypophyseal System/physiology ; Male ; Nuclear Proteins/genetics ; Pituitary-Adrenal System/physiology ; Poland ; Receptor, Serotonin, 5-HT1B/genetics ; Receptor, Serotonin, 5-HT2C/genetics ; Receptors, Catecholamine/genetics ; Stress, Psychological/genetics ; Transcription Factors ; Young Adult
Czasopismo naukowe
Tytuł :
Comparison of uptake transporter functions in hepatocytes in different species to determine the optimal model for evaluating drug transporter activities in humans.
Autorzy :
Liao M; a Takeda Pharmaceuticals, DMPK , Cambridge , MA , USA.
Zhu Q; b Takeda Pharmaceuticals International Co , Cambridge , MA , USA.
Zhu A; b Takeda Pharmaceuticals International Co , Cambridge , MA , USA.
Gemski C; b Takeda Pharmaceuticals International Co , Cambridge , MA , USA.
Ma B; b Takeda Pharmaceuticals International Co , Cambridge , MA , USA.
Guan E; a Takeda Pharmaceuticals, DMPK , Cambridge , MA , USA.
Li AP; c IVAL , Columbia , MD , USA.
Xiao G; b Takeda Pharmaceuticals International Co , Cambridge , MA , USA.
Xia CQ; b Takeda Pharmaceuticals International Co , Cambridge , MA , USA.
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Źródło :
Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2019 Jul; Vol. 49 (7), pp. 852-862. Date of Electronic Publication: 2018 Sep 21.
Typ publikacji :
Journal Article
MeSH Terms :
Models, Biological*
Catecholamine Plasma Membrane Transport Proteins/*metabolism
Hepatocytes/*metabolism
Octamer Transcription Factor-1/*metabolism
Organic Anion Transporters, Sodium-Dependent/*metabolism
Symporters/*metabolism
Adult ; Animals ; Atorvastatin/pharmacokinetics ; Atorvastatin/pharmacology ; Biological Transport, Active ; Estradiol/analogs & derivatives ; Estradiol/pharmacokinetics ; Estradiol/pharmacology ; Female ; Hepatocytes/cytology ; Humans ; Male ; Metformin/pharmacokinetics ; Metformin/pharmacology ; Middle Aged ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe

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