Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""Cathepsin B"" wg kryterium: Temat


Tytuł :
Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders.
Autorzy :
Hook V; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, United States of America; Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA, United States of America; Department of Neurosciences, School of Medicine, University of California San Diego, La Jolla, CA, United States of America. Electronic address: .
Yoon M; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, United States of America; Biomedical Sciences Graduate Program, University of California, San Diego, La Jolla, CA, United States of America.
Mosier C; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, United States of America.
Ito G; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, United States of America.
Podvin S; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, United States of America.
Head BP; VA San Diego Healthcare System, La Jolla, CA, United States of America; Department of Anesthesia, University of California San Diego, La Jolla, CA, United States of America.
Rissman R; Department of Neurosciences, School of Medicine, University of California San Diego, La Jolla, CA, United States of America; VA San Diego Healthcare System, La Jolla, CA, United States of America.
O'Donoghue AJ; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, United States of America.
Hook G; American Life Sciences Pharmaceuticals, Inc., La Jolla, CA, United States of America.
Pokaż więcej
Źródło :
Biochimica et biophysica acta. Proteins and proteomics [Biochim Biophys Acta Proteins Proteom] 2020 Aug; Vol. 1868 (8), pp. 140428. Date of Electronic Publication: 2020 Apr 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Review
MeSH Terms :
Alzheimer Disease/*enzymology
Brain/*enzymology
Brain Injuries, Traumatic/*enzymology
Cathepsin B/*genetics
Neurocognitive Disorders/*enzymology
Neurons/*enzymology
Adult ; Alzheimer Disease/drug therapy ; Alzheimer Disease/genetics ; Alzheimer Disease/pathology ; Animals ; Brain/drug effects ; Brain/pathology ; Brain Injuries, Traumatic/drug therapy ; Brain Injuries, Traumatic/genetics ; Brain Injuries, Traumatic/pathology ; Cathepsin B/antagonists & inhibitors ; Cathepsin B/metabolism ; Cell Death/drug effects ; Cell Death/genetics ; Child ; Cytosol/drug effects ; Cytosol/enzymology ; Disease Models, Animal ; Fetus ; Gene Expression Regulation ; Humans ; Infant ; Lysosomes/drug effects ; Lysosomes/enzymology ; Molecular Targeted Therapy ; Neurocognitive Disorders/drug therapy ; Neurocognitive Disorders/genetics ; Neurocognitive Disorders/pathology ; Neurons/drug effects ; Neurons/pathology ; Neuroprotective Agents/therapeutic use ; Signal Transduction
Czasopismo naukowe
Tytuł :
Cathepsin B Protease Facilitates Chikungunya Virus Envelope Protein-Mediated Infection via Endocytosis or Macropinocytosis.
Autorzy :
Izumida M; Department of Clinical Medicine, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan.
Hayashi H; Department, Medical University Research Administrator, Nagasaki University School of Medicine, Nagasaki 852-8523, Japan.
Tanaka A; Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan.
Kubo Y; Department of Clinical Medicine, Institute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan.; Program for Nurturing Global Leaders in Tropical and Emerging Communicable Diseases, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8523, Japan.
Pokaż więcej
Źródło :
Viruses [Viruses] 2020 Jul 03; Vol. 12 (7). Date of Electronic Publication: 2020 Jul 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Virus Internalization*
Cathepsin B/*metabolism
Chikungunya Fever/*pathology
Chikungunya virus/*physiology
Viral Envelope Proteins/*metabolism
Cathepsin B/antagonists & inhibitors ; Cell Line, Tumor ; Endocytosis/physiology ; Endosomes/virology ; HEK293 Cells ; HeLa Cells ; Humans ; Leukemia Virus, Murine/physiology ; Pinocytosis/physiology ; RNA Interference ; RNA, Small Interfering/genetics
Czasopismo naukowe
Tytuł :
Cathepsin B deficiency ameliorates liver lipid deposition, inflammatory cell infiltration, and fibrosis after diet-induced nonalcoholic steatohepatitis.
Autorzy :
Fang W; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, Shanghai, China.
Deng Z; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Department of Geriatrics, National Key Clinic Specialty, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
Benadjaoud F; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Yang C; Department of Geriatrics, National Key Clinic Specialty, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China. Electronic address: .
Shi GP; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Electronic address: .
Pokaż więcej
Źródło :
Translational research : the journal of laboratory and clinical medicine [Transl Res] 2020 Aug; Vol. 222, pp. 28-40. Date of Electronic Publication: 2020 May 11.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Diet, High-Fat*
Lipid Metabolism*
Cathepsin B/*deficiency
Inflammation/*pathology
Liver/*metabolism
Liver Cirrhosis/*complications
Liver Cirrhosis/*enzymology
Non-alcoholic Fatty Liver Disease/*complications
Animals ; Cadherins ; Cathepsin B/metabolism ; Cell Polarity ; Liver/pathology ; Liver/physiopathology ; Liver Cirrhosis/physiopathology ; Macrophages/pathology ; Male ; Mice, Inbred C57BL ; Non-alcoholic Fatty Liver Disease/enzymology ; Non-alcoholic Fatty Liver Disease/physiopathology ; Signal Transduction ; Smad Proteins/metabolism ; Transforming Growth Factor beta/metabolism ; Weight Gain
Czasopismo naukowe
Tytuł :
Interaction of a Trichinella spiralis cathepsin B with enterocytes promotes the larval intrusion into the cells.
Autorzy :
Han Y; Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou 450052, PR China.
Yue X; Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou 450052, PR China.
Hu CX; Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou 450052, PR China.
Liu F; Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou 450052, PR China.
Liu RD; Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou 450052, PR China.
He MM; Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou 450052, PR China.
Long SR; Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou 450052, PR China.
Cui J; Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou 450052, PR China. Electronic address: .
Wang ZQ; Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou 450052, PR China. Electronic address: .
Pokaż więcej
Źródło :
Research in veterinary science [Res Vet Sci] 2020 Jun; Vol. 130, pp. 110-117. Date of Electronic Publication: 2020 Mar 07.
Typ publikacji :
Journal Article
MeSH Terms :
Cathepsin B/*genetics
Enterocytes/*parasitology
Epithelial Cells/*parasitology
Helminth Proteins/*genetics
Intestinal Mucosa/*parasitology
Trichinella spiralis/*physiology
Animals ; Cathepsin B/metabolism ; Female ; Helminth Proteins/metabolism ; Larva/genetics ; Larva/growth & development ; Larva/physiology ; Mice ; Mice, Inbred BALB C ; Sequence Analysis, DNA/veterinary ; Trichinella spiralis/genetics ; Trichinella spiralis/growth & development ; Trichinellosis/parasitology
Czasopismo naukowe
Tytuł :
Rational Design of a Humanized Antibody Inhibitor of Cathepsin B.
Autorzy :
Dai Z; Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California 90089, United States.
Cheng Q; Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California 90089, United States.
Zhang Y; Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California 90089, United States.; Department of Chemistry, Dornsife College of Letters, Arts and Sciences, University of Southern California, Los Angeles, California 90089, United States.; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90089, United States.; Research Center for Liver Diseases, University of Southern California, Los Angeles, California 90089, United States.
Pokaż więcej
Źródło :
Biochemistry [Biochemistry] 2020 Apr 14; Vol. 59 (14), pp. 1420-1427. Date of Electronic Publication: 2020 Mar 31.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Antibodies/*chemistry
Cathepsin B/*antagonists & inhibitors
Enzyme Inhibitors/*chemistry
Animals ; Antibodies/administration & dosage ; Antibodies/genetics ; Antibodies/metabolism ; Cathepsin B/chemistry ; Cathepsin B/genetics ; Cathepsin B/metabolism ; Drug Design ; Enzyme Inhibitors/administration & dosage ; Enzyme Inhibitors/metabolism ; Female ; Humans ; Mice ; Neoplasms/drug therapy ; Neoplasms/enzymology ; Protein Domains
Czasopismo naukowe
Tytuł :
An optical biosensor for the determination of cathepsin B as a cancer-associated enzyme using nanoporous anodic alumina modified with human serum albumin-thionine.
Autorzy :
Amouzadeh Tabrizi M; Departamento de Ingeniería Electrónica, Eléctrica y Automática, Universitat Rovira i Virgili, Avda. Països Catalans 26, 43007, Tarragona, Spain.
Ferré-Borrull J; Departamento de Ingeniería Electrónica, Eléctrica y Automática, Universitat Rovira i Virgili, Avda. Països Catalans 26, 43007, Tarragona, Spain.
Marsal LF; Departamento de Ingeniería Electrónica, Eléctrica y Automática, Universitat Rovira i Virgili, Avda. Països Catalans 26, 43007, Tarragona, Spain. .
Pokaż więcej
Źródło :
Mikrochimica acta [Mikrochim Acta] 2020 Mar 13; Vol. 187 (4), pp. 230. Date of Electronic Publication: 2020 Mar 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biosensing Techniques*
Electrochemical Techniques*
Aluminum Oxide/*chemistry
Cathepsin B/*analysis
Phenothiazines/*chemistry
Serum Albumin, Human/*chemistry
Cathepsin B/metabolism ; Electrodes ; Humans ; Optical Phenomena ; Particle Size ; Porosity ; Surface Properties
Czasopismo naukowe
Tytuł :
Cathepsin B-associated Activation of Amyloidogenic Pathway in Murine Mucopolysaccharidosis Type I Brain Cortex.
Autorzy :
Viana GM; Department of Biochemistry, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP 04044-020, Brazil.
Gonzalez EA; Gene Therapy Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS 90035-903, Brazil.
Alvarez MMP; Department of Biochemistry, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP 04044-020, Brazil.
Cavalheiro RP; Department of Biochemistry, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP 04044-020, Brazil.
do Nascimento CC; Department of Psychobiology, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP 04024-002, Brazil.
Baldo G; Gene Therapy Center, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS 90035-903, Brazil.
D'Almeida V; Department of Psychobiology, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP 04024-002, Brazil.
de Lima MA; Molecular & Structural Biosciences, School of Life Sciences, Keele University, Huxley Building, Keele, Staffordshire ST5 5BG, UK.
Pshezhetsky AV; Division of Medical Genetics, CHU Ste-Justine Research Centre, Montreal, QC H3T 1C5, Canada.
Nader HB; Department of Biochemistry, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP 04044-020, Brazil.
Pokaż więcej
Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Feb 20; Vol. 21 (4). Date of Electronic Publication: 2020 Feb 20.
Typ publikacji :
Journal Article
MeSH Terms :
Amyloid beta-Protein Precursor/*metabolism
Cathepsin B/*metabolism
Cerebral Cortex/*metabolism
Mucopolysaccharidosis I/*metabolism
Pyramidal Cells/*metabolism
Amyloid beta-Protein Precursor/genetics ; Animals ; Astrocytes/metabolism ; Astrocytes/pathology ; Cathepsin B/genetics ; Cerebral Cortex/pathology ; Glial Fibrillary Acidic Protein/genetics ; Glial Fibrillary Acidic Protein/metabolism ; Lysosomes/metabolism ; Lysosomes/pathology ; Mice ; Mice, Knockout ; Mucopolysaccharidosis I/genetics ; Mucopolysaccharidosis I/pathology ; Pyramidal Cells/pathology
Czasopismo naukowe
Tytuł :
Dynamic status of lysosomal cathepsin in bovine oocytes and preimplantation embryos.
Autorzy :
Li J; Laboratory of Animal Genetics and Reproduction, Graduate School of Agriculture, Hokkaido University, Hokkaido 060-8589, Japan.
Maeji M; Laboratory of Animal Genetics and Reproduction, Graduate School of Agriculture, Hokkaido University, Hokkaido 060-8589, Japan.
Balboula AZ; Animal Sciences Research Center, College of Agriculture, Food & Natural Resources, University of Missouri, Columbia, MO 65211, USA.
Aboelenain M; Department of Theriogenology, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt.
Fujii T; Animal Research Center, Hokkaido Research Organization, Hokkaido 081-0038, Japan.
Moriyasu S; Animal Research Center, Hokkaido Research Organization, Hokkaido 081-0038, Japan.
Bai H; Laboratory of Animal Genetics and Reproduction, Graduate School of Agriculture, Hokkaido University, Hokkaido 060-8589, Japan.
Kawahara M; Laboratory of Animal Genetics and Reproduction, Graduate School of Agriculture, Hokkaido University, Hokkaido 060-8589, Japan.
Takahashi M; Graduate School of Global Food Resources(GSF), Hokkaido University, Hokkaido 060-0809, Japan.; Global Station for Food, Land and Water Resources, Global Institution for Collaborative Research and Education(GI-CoRE), Hokkaido University, Hokkaido, 060-0815, Japan.
Pokaż więcej
Źródło :
The Journal of reproduction and development [J Reprod Dev] 2020 Feb 14; Vol. 66 (1), pp. 9-17. Date of Electronic Publication: 2019 Nov 03.
Typ publikacji :
Journal Article
MeSH Terms :
Blastocyst/*metabolism
Cathepsin B/*metabolism
Lysosomes/*metabolism
Oocytes/*metabolism
Animals ; Cathepsin B/genetics ; Cattle ; Embryo, Mammalian/metabolism ; Embryonic Development ; Female ; Gene Expression Regulation, Developmental ; Pregnancy
Czasopismo naukowe
Tytuł :
Spatially and temporally defined lysosomal leakage facilitates mitotic chromosome segregation.
Autorzy :
Hämälistö S; Cell Death and Metabolism, Center for Autophagy, Recycling and Disease, Danish Cancer Society Research Center, 2100, Copenhagen, Denmark.
Stahl JL; Cell Death and Metabolism, Center for Autophagy, Recycling and Disease, Danish Cancer Society Research Center, 2100, Copenhagen, Denmark.
Favaro E; Cell Death and Metabolism, Center for Autophagy, Recycling and Disease, Danish Cancer Society Research Center, 2100, Copenhagen, Denmark.
Yang Q; Cell Death and Metabolism, Center for Autophagy, Recycling and Disease, Danish Cancer Society Research Center, 2100, Copenhagen, Denmark.
Liu B; Cell Death and Metabolism, Center for Autophagy, Recycling and Disease, Danish Cancer Society Research Center, 2100, Copenhagen, Denmark.
Christoffersen L; Cell Death and Metabolism, Center for Autophagy, Recycling and Disease, Danish Cancer Society Research Center, 2100, Copenhagen, Denmark.
Loos B; Department of Physiological Sciences, Stellenbosch University, 7600, Stellenbosch, South Africa.
Guasch Boldú C; Cell Division and Cytoskeleton, Danish Cancer Society Research Center, 2100, Copenhagen, Denmark.
Joyce JA; Ludwig Institute for Cancer Research, University of Lausanne, 1005, Lausanne, Switzerland.
Reinheckel T; Institute of Molecular Medicine and Cell Research, Medical Faculty, University of Freiburg, 79104, Freiburg, Germany.; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, partner site Freiburg, 79106, Freiburg, Germany.
Barisic M; Cell Division and Cytoskeleton, Danish Cancer Society Research Center, 2100, Copenhagen, Denmark.; Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, 2200, Copenhagen, Denmark.
Jäättelä M; Cell Death and Metabolism, Center for Autophagy, Recycling and Disease, Danish Cancer Society Research Center, 2100, Copenhagen, Denmark. .; Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, 2200, Copenhagen, Denmark. .
Pokaż więcej
Źródło :
Nature communications [Nat Commun] 2020 Jan 13; Vol. 11 (1), pp. 229. Date of Electronic Publication: 2020 Jan 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromosome Segregation*/genetics
Mitosis*/genetics
Cathepsin B/*metabolism
Chromatin/*metabolism
Lysosomes/*metabolism
Animals ; Cathepsin B/antagonists & inhibitors ; Cathepsin B/genetics ; Cell Line ; Cell Nucleus/genetics ; Cell Nucleus/pathology ; Female ; Gene Silencing ; Histones/metabolism ; Humans ; Intracellular Membranes/metabolism ; Lysosomes/enzymology ; Metaphase ; Mice ; Permeability ; Telomere/metabolism
Czasopismo naukowe
Tytuł :
Integration of a peptide-DNA conjugate with multiple cyclic signal amplification for the ultrasensitive detection of cathepsin B activity.
Autorzy :
Wang ZY; College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals, Shandong Normal University, Jinan 250014, China. .
Zhang CP; College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals, Shandong Normal University, Jinan 250014, China. .
Zhang CY; College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals, Shandong Normal University, Jinan 250014, China. .
Pokaż więcej
Źródło :
Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2020 Feb 18; Vol. 56 (14), pp. 2119-2122. Date of Electronic Publication: 2020 Jan 23.
Typ publikacji :
Journal Article
MeSH Terms :
Nucleic Acid Amplification Techniques*
Cathepsin B/*analysis
DNA/*chemistry
Peptides/*chemistry
Cathepsin B/metabolism ; DNA/genetics ; DNA/metabolism ; HEK293 Cells ; HeLa Cells ; Humans ; Optical Imaging ; Peptides/genetics ; Peptides/metabolism
Czasopismo naukowe
Tytuł :
Genetic modifiers of risk and age at onset in GBA associated Parkinson's disease and Lewy body dementia.
Autorzy :
Blauwendraat C; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Reed X; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Krohn L; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.; Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Heilbron K; 23andMe, Inc., Mountain View, CA, USA.
Bandres-Ciga S; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Tan M; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.
Gibbs JR; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Hernandez DG; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Kumaran R; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Langston R; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Bonet-Ponce L; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Alcalay RN; Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.; Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York, NY, USA.
Hassin-Baer S; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; Department of Neurology, Sheba Medical Center, Tel Hashomer, Israel.; Movement Disorders Institute, Sheba Medical Center, Tel Hashomer, Israel.; The Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel Hashomer, Israel.
Greenbaum L; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.; The Joseph Sagol Neuroscience Center, Sheba Medical Center, Tel Hashomer, Israel.; The Danek Gertner Institute of Human Genetics, Sheba Medical Center, Tel Hashomer, Israel.
Iwaki H; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Leonard HL; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Grenn FP; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Ruskey JA; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.; Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.
Sabir M; Neurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Ahmed S; Neurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Makarious MB; Neurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Pihlstrøm L; Department of Neurology, Oslo University Hospital, Oslo, Norway.
Toft M; Department of Neurology, Oslo University Hospital, Oslo, Norway.
van Hilten JJ; Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands.
Marinus J; Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands.
Schulte C; Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Tuebingen, Germany.
Brockmann K; Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Tuebingen, Germany.
Sharma M; Centre for Genetic Epidemiology, Institute for Clinical Epidemiology and Applied Biometry, University of Tubingen, Germany.
Siitonen A; Institute of Clinical Medicine, Department of Neurology, University of Oulu, Oulu, Finland.; Department of Neurology and Medical Research Center, Oulu University Hospital, Oulu, Finland.
Majamaa K; Institute of Clinical Medicine, Department of Neurology, University of Oulu, Oulu, Finland.; Department of Neurology and Medical Research Center, Oulu University Hospital, Oulu, Finland.
Eerola-Rautio J; Department of Neurology, Helsinki University Hospital, and Molecular Neurology, Research Programs Unit, Biomedicum, University of Helsinki, Helsinki, Finland.
Tienari PJ; Department of Neurology, Helsinki University Hospital, and Molecular Neurology, Research Programs Unit, Biomedicum, University of Helsinki, Helsinki, Finland.
Pantelyat A; Neuroregeneration and Stem Cell Program, Institute for Cell Engineering, Johns Hopkins University Medical Center, Baltimore, MD, USA.
Hillis AE; Neuroregeneration and Stem Cell Program, Institute for Cell Engineering, Johns Hopkins University Medical Center, Baltimore, MD, USA.
Dawson TM; Neuroregeneration and Stem Cell Program, Institute for Cell Engineering, Johns Hopkins University Medical Center, Baltimore, MD, USA.; Department of Neurology, Johns Hopkins University Medical Center, Baltimore, MD, USA.
Rosenthal LS; Department of Neurology, Johns Hopkins University Medical Center, Baltimore, MD, USA.
Albert MS; Department of Neurology, Johns Hopkins University Medical Center, Baltimore, MD, USA.
Resnick SM; Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD, USA.
Ferrucci L; Longitudinal Studies Section, National Institute on Aging, Baltimore, MD, USA.
Morris CM; Newcastle Brain Tissue Resource, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.
Pletnikova O; Department of Pathology (Neuropathology, Johns Hopkins University Medical Center, Baltimore, MD, USA.
Troncoso J; Department of Neurology, Johns Hopkins University Medical Center, Baltimore, MD, USA.; Department of Pathology (Neuropathology, Johns Hopkins University Medical Center, Baltimore, MD, USA.
Grosset D; Department of Neurology, Institute of Neurological Sciences, Queen Elizabeth University Hospital, Glasgow, UK.
Lesage S; Inserm U1127, Sorbonne Universités, UPMC Univ Paris 06 UMR S1127, Institut du Cerveau et de la Moelle épinière, ICM, Paris, France.
Corvol JC; Inserm U1127, Sorbonne Universités, UPMC Univ Paris 06 UMR S1127, Institut du Cerveau et de la Moelle épinière, ICM, Paris, France.
Brice A; Inserm U1127, Sorbonne Universités, UPMC Univ Paris 06 UMR S1127, Institut du Cerveau et de la Moelle épinière, ICM, Paris, France.
Noyce AJ; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.; Preventive Neurology Unit, Wolfson Institute of Preventive Medicine, Queen Mary University of London, London, UK.
Masliah E; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Wood N; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.
Hardy J; Department of Neurodegenerative Diseases, UCL Queen Square Institute of Neurology, London, UK.
Shulman LM; Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA.
Jankovic J; Department of Neurology, Baylor College of Medicine, Houston, USA.
Shulman JM; Department of Neurology, Baylor College of Medicine, Houston, USA.; Departments of Molecular and Human Genetics and Neuroscience, Baylor College of Medicine, Houston, USA.; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, USA.
Heutink P; Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Tuebingen, Germany.
Gasser T; Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Tuebingen, Germany.
Cannon P; 23andMe, Inc., Mountain View, CA, USA.
Scholz SW; Neurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.; Department of Neurology, Johns Hopkins University Medical Center, Baltimore, MD, USA.
Morris H; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, UK.
Cookson MR; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Nalls MA; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.; Data Tecnica International, Glen Echo, MD, USA.
Gan-Or Z; Department of Human Genetics, McGill University, Montreal, Quebec, Canada.; Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada.; Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
Singleton AB; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Pokaż więcej
Corporate Authors :
23andMe Research Team
Źródło :
Brain : a journal of neurology [Brain] 2020 Jan 01; Vol. 143 (1), pp. 234-248.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Penetrance*
Cathepsin B/*genetics
Glucosylceramidase/*genetics
Lewy Body Disease/*genetics
Parkinson Disease/*genetics
alpha-Synuclein/*genetics
Age of Onset ; Case-Control Studies ; Cathepsin B/metabolism ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Genotype ; Glucosylceramidase/metabolism ; Humans ; Induced Pluripotent Stem Cells ; Lewy Body Disease/metabolism ; Neurogenesis/genetics ; Neurons/metabolism ; Parkinson Disease/metabolism ; Polymorphism, Single Nucleotide ; RNA, Messenger/metabolism ; Risk Factors ; Whole Genome Sequencing ; alpha-Synuclein/metabolism
Czasopismo naukowe
Tytuł :
UAA and UAG may Encode Amino Acid in Cathepsin B Gene of Euplotes octocarinatus.
Autorzy :
Wang R; Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Biotechnology, Shanxi University, Taiyuan, 030006, China.
Liu J; Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Biotechnology, Shanxi University, Taiyuan, 030006, China.
Di Giuseppe G; Department of Biology, University of Pisa, Pisa, 56126, Italy.
Liang A; Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Institute of Biotechnology, Shanxi University, Taiyuan, 030006, China.
Pokaż więcej
Źródło :
The Journal of eukaryotic microbiology [J Eukaryot Microbiol] 2020 Jan; Vol. 67 (1), pp. 144-149. Date of Electronic Publication: 2019 Sep 02.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cathepsin B/*genetics
Euplotes/*genetics
Protozoan Proteins/*genetics
Amino Acid Sequence ; Base Sequence ; Cathepsin B/metabolism ; Codon, Terminator ; Euplotes/enzymology ; Euplotes/metabolism ; Protozoan Proteins/metabolism ; Sequence Alignment
Czasopismo naukowe
Tytuł :
Schistosoma japonicum cathepsin B2 (SjCB2) facilitates parasite invasion through the skin.
Autorzy :
Zhu, Bingkuan (AUTHOR)
Luo, Fang (AUTHOR)
Shen, Yi (AUTHOR)
Yang, Wenbin (AUTHOR)
Sun, Chengsong (AUTHOR)
Wang, Jipeng (AUTHOR)
Li, Jian (AUTHOR)
Mo, Xiaojin (AUTHOR)
Xu, Bin (AUTHOR)
Zhang, Xumin (AUTHOR)
Li, Yongdong (AUTHOR)
Hu, Wei (AUTHOR)
Pokaż więcej
Źródło :
PLoS Neglected Tropical Diseases. 10/26/2020, Vol. 14 Issue 10, p1-23. 23p.
Czasopismo naukowe
Tytuł :
Vaccination of mice with a recombinant novel cathepsin B inhibits Trichinella spiralis development, reduces the fecundity and worm burden.
Autorzy :
Cui J; Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou, 450052, China. .
Han Y; Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou, 450052, China.
Yue X; Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou, 450052, China.
Liu F; Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou, 450052, China.
Song YY; Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou, 450052, China.
Yan SW; Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou, 450052, China.
Lei JJ; Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou, 450052, China.
Zhang X; Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou, 450052, China.
Jiang P; Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou, 450052, China. .
Wang ZQ; Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou, 450052, China. .
Pokaż więcej
Źródło :
Parasites & vectors [Parasit Vectors] 2019 Dec 11; Vol. 12 (1), pp. 581. Date of Electronic Publication: 2019 Dec 11.
Typ publikacji :
Journal Article
MeSH Terms :
Antigens, Helminth/*immunology
Cathepsin B/*immunology
Trichinella spiralis/*immunology
Trichinellosis/*prevention & control
Vaccines, Synthetic/*immunology
Animals ; Antibodies, Helminth/blood ; Antigens, Helminth/administration & dosage ; Cathepsin B/administration & dosage ; Disease Models, Animal ; Enzyme-Linked Immunosorbent Assay ; Fertility ; Immunoglobulin E/blood ; Immunoglobulin G/blood ; Injections, Subcutaneous ; Mice ; Parasite Load ; Treatment Outcome ; Trichinella spiralis/growth & development ; Trichinella spiralis/isolation & purification ; Trichinellosis/parasitology ; Trichinellosis/pathology ; Vaccines, Synthetic/administration & dosage
Czasopismo naukowe
Tytuł :
Cathepsin B Turning Bioluminescence "On" for Tumor Imaging.
Autorzy :
Ni Y; Hefei National Laboratory of Physical Sciences at Microscale, Department of Chemistry , University of Science and Technology of China , 96 Jinzhai Road , Hefei , Anhui 230026 , China.
Hai Z; Institutes of Physical Science and Information Technology , Anhui University , 110 Jiulong Road , Hefei , Anhui 230601 , China.
Zhang T; School of Life Sciences , University of Science and Technology of China , 443 Huangshan Road , Hefei , Anhui 230027 , China.
Wang Y; Hefei National Laboratory of Physical Sciences at Microscale, Department of Chemistry , University of Science and Technology of China , 96 Jinzhai Road , Hefei , Anhui 230026 , China.
Yang Y; Center of Advanced Analysis & Gene Sequencing , Zhengzhou University , 100 Kexue Road , Zhengzhou , Henan 450001 , China.
Zhang S; Center of Advanced Analysis & Gene Sequencing , Zhengzhou University , 100 Kexue Road , Zhengzhou , Henan 450001 , China.
Liang G; Hefei National Laboratory of Physical Sciences at Microscale, Department of Chemistry , University of Science and Technology of China , 96 Jinzhai Road , Hefei , Anhui 230026 , China.
Pokaż więcej
Źródło :
Analytical chemistry [Anal Chem] 2019 Dec 03; Vol. 91 (23), pp. 14834-14837. Date of Electronic Publication: 2019 Nov 19.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Biomarkers, Tumor/*genetics
Breast Neoplasms/*diagnostic imaging
Cathepsin B/*genetics
Diagnostic Imaging/*methods
Molecular Probes/*pharmacokinetics
Animals ; Biomarkers, Tumor/antagonists & inhibitors ; Biomarkers, Tumor/metabolism ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cathepsin B/antagonists & inhibitors ; Cathepsin B/metabolism ; Cell Line, Tumor ; Dipeptides/pharmacology ; Female ; Gene Expression ; Heterografts ; Humans ; Luminescent Measurements ; Lysosomes/drug effects ; Lysosomes/enzymology ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Molecular Probes/chemical synthesis
Czasopismo naukowe
Tytuł :
Screening of cathepsin B inhibitors in traditional Chinese medicine by capillary electrophoresis with immobilized enzyme microreactor.
Autorzy :
Zhang B; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University School of Pharmaceutical Sciences, Wuhan, 430071, China; State Key Laboratory of Transducer Technology, Chinese Academy of Sciences, Beijing, 10080, China.
Chen Z; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Wuhan University School of Pharmaceutical Sciences, Wuhan, 430071, China; State Key Laboratory of Transducer Technology, Chinese Academy of Sciences, Beijing, 10080, China. Electronic address: .
Pokaż więcej
Źródło :
Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2019 Nov 30; Vol. 176, pp. 112811. Date of Electronic Publication: 2019 Aug 13.
Typ publikacji :
Journal Article
MeSH Terms :
Cathepsin B/*antagonists & inhibitors
Drug Discovery/*methods
Drugs, Chinese Herbal/*analysis
Amaryllidaceae Alkaloids/chemistry ; Amaryllidaceae Alkaloids/isolation & purification ; Amaryllidaceae Alkaloids/pharmacology ; Cathepsin B/chemistry ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacology ; Electrophoresis, Capillary/methods ; Enzymes, Immobilized/chemistry ; Feasibility Studies ; Indole Alkaloids/chemistry ; Indole Alkaloids/isolation & purification ; Indole Alkaloids/pharmacology ; Indolizines/chemistry ; Indolizines/isolation & purification ; Indolizines/pharmacology ; Kaempferols/chemistry ; Kaempferols/isolation & purification ; Kaempferols/pharmacology ; Molecular Docking Simulation ; Quinazolines/chemistry ; Quinazolines/isolation & purification ; Quinazolines/pharmacology ; Theophylline/chemistry ; Theophylline/isolation & purification ; Theophylline/pharmacology
Czasopismo naukowe
Tytuł :
Design and synthesis of fluorogenic substrate-based probes for detecting Cathepsin B activity.
Autorzy :
Wang S; Department of Chemistry, University of Saskatchewan, 110 Science Place, Saskatoon, SK S7N 5C9, Canada.
Vigliarolo BG; Department of Chemistry, University of Saskatchewan, 110 Science Place, Saskatoon, SK S7N 5C9, Canada.
Chowdhury MA; Department of Chemistry, University of Saskatchewan, 110 Science Place, Saskatoon, SK S7N 5C9, Canada.
Nyarko JNK; Cell Signalling Laboratory, Department of Psychiatry, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada.
Mousseau DD; Cell Signalling Laboratory, Department of Psychiatry, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada.
Phenix CP; Department of Chemistry, University of Saskatchewan, 110 Science Place, Saskatoon, SK S7N 5C9, Canada. Electronic address: .
Pokaż więcej
Źródło :
Bioorganic chemistry [Bioorg Chem] 2019 Nov; Vol. 92, pp. 103194. Date of Electronic Publication: 2019 Aug 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cadaverine/*analogs & derivatives
Cathepsin B/*analysis
Fluorescent Dyes/*chemical synthesis
Fluorescent Dyes/*metabolism
Neoplasms/*diagnostic imaging
Aminobiphenyl Compounds/chemistry ; Cadaverine/chemical synthesis ; Cadaverine/metabolism ; Cathepsin B/metabolism ; Cathepsin L/analysis ; Cathepsin L/metabolism ; Cell Line, Tumor ; Humans ; Hydrolysis ; Kinetics ; Microscopy, Confocal ; Molecular Structure ; Optical Imaging ; Recombinant Proteins/analysis ; Recombinant Proteins/metabolism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Cathepsin B increases ENaC activity leading to hypertension early in nephrotic syndrome.
Autorzy :
Larionov A; Institute of Anatomy, Department of Medicine, University of Fribourg, Fribourg, Switzerland.
Dahlke E; Institute of Anatomy, Christian Albrechts-University Kiel, Kiel, Germany.
Kunke M; Institute of Anatomy, Christian Albrechts-University Kiel, Kiel, Germany.
Zanon Rodriguez L; Institute of Anatomy, Christian Albrechts-University Kiel, Kiel, Germany.
Schiessl IM; Institute of Physiology, University of Regensburg, Regensburg, Germany.
Magnin JL; Service LaboratoireHôpital Fribourg, Fribourg, Switzerland.
Kern U; Institute of Molecular Medicine and Cell Research, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Alli AA; Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida.
Mollet G; Laboratory of Hereditary Kidney Diseases, INSERM UMR 1163, Université Paris Descartes-Sorbonne Paris Cité, Imagine Institute, Paris, France.
Schilling O; Institute of Molecular Medicine and Cell Research, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; BIOSS Center for Biological Signaling Studies, University of Freiburg, Freiburg, Germany.
Castrop H; Institute of Physiology, University of Regensburg, Regensburg, Germany.
Theilig F; Institute of Anatomy, Department of Medicine, University of Fribourg, Fribourg, Switzerland.; Institute of Anatomy, Christian Albrechts-University Kiel, Kiel, Germany.
Pokaż więcej
Źródło :
Journal of cellular and molecular medicine [J Cell Mol Med] 2019 Oct; Vol. 23 (10), pp. 6543-6553. Date of Electronic Publication: 2019 Jul 31.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cathepsin B/*metabolism
Epithelial Sodium Channels/*metabolism
Hypertension/*etiology
Hypertension/*metabolism
Nephrotic Syndrome/*complications
Nephrotic Syndrome/*metabolism
Amiloride/pharmacology ; Animals ; Cathepsin B/antagonists & inhibitors ; Cathepsin B/genetics ; Epithelial Sodium Channel Blockers/pharmacology ; Glomerulosclerosis, Focal Segmental/enzymology ; Glomerulosclerosis, Focal Segmental/genetics ; Glomerulosclerosis, Focal Segmental/metabolism ; Glomerulosclerosis, Focal Segmental/urine ; Hypertension/genetics ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Kidney Tubules/cytology ; Kidney Tubules/metabolism ; Lysosomes/enzymology ; Lysosomes/metabolism ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mice ; Mice, Transgenic ; Nephrotic Syndrome/genetics ; Proteinuria/metabolism ; Proteolysis ; Sodium/metabolism
Czasopismo naukowe
Tytuł :
Gene Expression in Intracranial Aneurysms-Comparison Analysis of Aneurysmal Walls and Extracranial Arteries with Real-Time Polymerase Chain Reaction and Immunohistochemistry.
Autorzy :
Tyagi G; Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bangalore, India.
Srinivas D; Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bangalore, India. Electronic address: .
Nanjaiah ND; Department of Neurochemistry, National Institute of Mental Health and Neurosciences, Bangalore, India.
Purushottam M; Department of Molecular Genetics Lab, National Institute of Mental Health and Neurosciences, Bangalore, India.
Somanna S; Department of Neurosurgery, National Institute of Mental Health and Neurosciences, Bangalore, India.
Santosh V; Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bangalore, India.
Jain S; Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India.
Pokaż więcej
Źródło :
World neurosurgery [World Neurosurg] 2019 Oct; Vol. 130, pp. e117-e126. Date of Electronic Publication: 2019 Jun 13.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression*
Arteries/*metabolism
Cathepsin B/*metabolism
Collagen Type I/*metabolism
Intracranial Aneurysm/*genetics
Intracranial Aneurysm/*metabolism
Tissue Inhibitor of Metalloproteinases/*metabolism
alpha 1-Antitrypsin/*metabolism
Adult ; Aged ; Carotid Artery, External/metabolism ; Cathepsin B/genetics ; Collagen Type I/genetics ; Female ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Neck/blood supply ; Prospective Studies ; Real-Time Polymerase Chain Reaction ; Scalp/blood supply ; Tissue Inhibitor of Metalloproteinases/genetics ; Young Adult ; alpha 1-Antitrypsin/genetics
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies