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Tytuł:
In vivo imaging of cathepsin B in activated glia in the brain after orofacial formalin test.
Autorzy:
McIlwrath SL; New Mexico VA Health Care System, Albuquerque, NM, 87108, USA. .
Carroll-Portillo AC; New Mexico VA Health Care System, Albuquerque, NM, 87108, USA.; Division of Gastroenterology and Hepatology, University of New Mexico, Albuquerque, NM, 87131, USA.
Lin HC; New Mexico VA Health Care System, Albuquerque, NM, 87108, USA.; Division of Gastroenterology and Hepatology, University of New Mexico, Albuquerque, NM, 87131, USA.
Westlund KN; New Mexico VA Health Care System, Albuquerque, NM, 87108, USA.; Department of Anesthesiology and Critical Care Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, 87106, USA.
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Źródło:
Scientific reports [Sci Rep] 2024 Feb 24; Vol. 14 (1), pp. 4517. Date of Electronic Publication: 2024 Feb 24.
Typ publikacji:
Journal Article
MeSH Terms:
Cathepsin B*/metabolism
Fluorescent Dyes*/metabolism
Rats ; Animals ; Pain Measurement ; Brain/diagnostic imaging ; Brain/metabolism ; Microglia/metabolism ; Facial Pain/metabolism ; Formaldehyde/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cannabinoid receptor type 2 agonist JWH-133 decreases cathepsin B secretion and neurotoxicity from HIV-infected macrophages.
Autorzy:
Rosario-Rodríguez LJ; Department of Microbiology and Medical Zoology, School of Medicine, Medical Sciences Campus, University of Puerto Rico, San Juan, PR, 00935, USA.
Gerena Y; Department of Pharmacology, University of Puerto Rico, Medical Sciences Campus, San Juan, PR, USA.
García-Requena LA; Department of Biology, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR, USA.
Cartagena-Isern LJ; Department of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR, USA.
Cuadrado-Ruiz JC; Department of Biology, University of Puerto Rico, Bayamón Campus, Bayamón, PR, USA.
Borges-Vélez G; Department of Microbiology and Medical Zoology, School of Medicine, Medical Sciences Campus, University of Puerto Rico, San Juan, PR, 00935, USA.
Meléndez LM; Department of Microbiology and Medical Zoology, School of Medicine, Medical Sciences Campus, University of Puerto Rico, San Juan, PR, 00935, USA. .
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Źródło:
Scientific reports [Sci Rep] 2022 Jan 07; Vol. 12 (1), pp. 233. Date of Electronic Publication: 2022 Jan 07.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Cannabinoids/*pharmacology
Cathepsin B/*metabolism
HIV Infections/*complications
Macrophages/*drug effects
Neurocognitive Disorders/*etiology
Receptor, Cannabinoid, CB2/*agonists
Apoptosis/drug effects ; Cathepsin B/genetics ; Cathepsin B/toxicity ; HIV Infections/virology ; HIV-1/physiology ; Humans ; Macrophages/cytology ; Macrophages/metabolism ; Neurocognitive Disorders/genetics ; Neurocognitive Disorders/metabolism ; Neurocognitive Disorders/physiopathology ; Neurons/cytology ; Neurons/metabolism ; Receptor, Cannabinoid, CB2/genetics ; Receptor, Cannabinoid, CB2/metabolism ; Virus Replication/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cathepsin B and D deficiency in the mouse pancreas induces impaired autophagy and chronic pancreatitis.
Autorzy:
Iwama H; Department of Genetics, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan.; Department of Gastroenterological Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo, 663-8501, Japan.
Mehanna S; Institute of Resource Development and Analysis, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto, 860-0811, Japan.; Department of Veterinary Hygiene and Management, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt.
Imasaka M; Department of Genetics, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan.
Hashidume S; Department of Genetics, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan.
Nishiura H; Division of Functional Pathology, Department of Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo, 663-8501, Japan.
Yamamura KI; Institute of Resource Development and Analysis, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto, 860-0811, Japan.
Suzuki C; Department of Pharmacology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Uchiyama Y; Department of Cell Biology and Neuroscience, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Hatano E; Department of Gastroenterological Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo, 663-8501, Japan.
Ohmuraya M; Department of Genetics, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2021 Mar 23; Vol. 11 (1), pp. 6596. Date of Electronic Publication: 2021 Mar 23.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Autophagy*
Cathepsin B/*deficiency
Cathepsin D/*deficiency
Pancreas/*metabolism
Pancreatitis, Chronic/*metabolism
Acinar Cells/metabolism ; Animals ; Autophagosomes/metabolism ; Cathepsin B/genetics ; Cathepsin B/metabolism ; Cathepsin D/genetics ; Cathepsin D/metabolism ; Mice ; Pancreas/cytology ; Pancreatitis, Chronic/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
HIV Infection Induces Extracellular Cathepsin B Uptake and Damage to Neurons.
Autorzy:
Cantres-Rosario YM; University of Puerto Rico, Medical Sciences Campus, Department of Microbiology and Medical Zoology, San Juan, PR, USA.
Ortiz-Rodríguez SC; University of Puerto Rico, Medical Sciences Campus, Department of Microbiology and Medical Zoology, San Juan, PR, USA.
Santos-Figueroa AG; University of Puerto Rico, Bayamon Campus, Department of Biology, Bayamon, PR, USA.
Plaud M; University of Puerto Rico, Medical Sciences Campus, Department of Microbiology and Medical Zoology, San Juan, PR, USA.
Negron K; University of Puerto Rico, Bayamon Campus, Department of Biology, Bayamon, PR, USA.
Cotto B; Lewis Katz School of Medicine at Temple University, Department of Neuroscience and Center for Neurovirology, Philadelphia, PA, USA.
Langford D; Lewis Katz School of Medicine at Temple University, Department of Neuroscience and Center for Neurovirology, Philadelphia, PA, USA.
Melendez LM; University of Puerto Rico, Medical Sciences Campus, Department of Microbiology and Medical Zoology, San Juan, PR, USA. .
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Źródło:
Scientific reports [Sci Rep] 2019 May 29; Vol. 9 (1), pp. 8006. Date of Electronic Publication: 2019 May 29.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
AIDS Dementia Complex/*genetics
Cathepsin B/*genetics
Endoribonucleases/*genetics
HIV Infections/*metabolism
Neoplasm Proteins/*genetics
Neurons/*metabolism
AIDS Dementia Complex/metabolism ; AIDS Dementia Complex/physiopathology ; Apoptosis/drug effects ; Apoptosis/genetics ; Blood-Brain Barrier/metabolism ; Caspase 3/genetics ; Cathepsin B/metabolism ; Cell Line ; Cells, Cultured ; Culture Media, Conditioned/metabolism ; Culture Media, Conditioned/pharmacology ; Deoxyribonucleases, Type II Site-Specific ; Endoribonucleases/metabolism ; Extracellular Vesicles/metabolism ; Extracellular Vesicles/pathology ; Flow Cytometry ; HIV Infections/complications ; HIV Infections/physiopathology ; HIV-1/pathogenicity ; Hippocampus/metabolism ; Hippocampus/pathology ; Histidine/metabolism ; Humans ; Macrophages/metabolism ; Macrophages/pathology ; Neoplasm Proteins/metabolism ; Neurons/pathology ; Synaptophysin/genetics
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
CTSB is a negative prognostic biomarker and therapeutic target associated with immune cells infiltration and immunosuppression in gliomas.
Autorzy:
Ma K; Department of Neurosurgery, Peking University Third Hospital, 49 North Garden Rd, Haidian District, Beijing, 100191, China.; Center for Precision Neurosurgery and Oncology of Peking University Health Science Center, Beijing, China.
Chen X; Department of Neurosurgery, Peking University Third Hospital, 49 North Garden Rd, Haidian District, Beijing, 100191, China.; Center for Precision Neurosurgery and Oncology of Peking University Health Science Center, Beijing, China.
Liu W; Department of Neurosurgery, Peking University Third Hospital, 49 North Garden Rd, Haidian District, Beijing, 100191, China.; Center for Precision Neurosurgery and Oncology of Peking University Health Science Center, Beijing, China.
Chen S; Department of Neurosurgery, Peking University Third Hospital, 49 North Garden Rd, Haidian District, Beijing, 100191, China.; Center for Precision Neurosurgery and Oncology of Peking University Health Science Center, Beijing, China.
Yang C; Department of Neurosurgery, Peking University Third Hospital, 49 North Garden Rd, Haidian District, Beijing, 100191, China.
Yang J; Department of Neurosurgery, Peking University Third Hospital, 49 North Garden Rd, Haidian District, Beijing, 100191, China. .; Center for Precision Neurosurgery and Oncology of Peking University Health Science Center, Beijing, China. .
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Źródło:
Scientific reports [Sci Rep] 2022 Mar 11; Vol. 12 (1), pp. 4295. Date of Electronic Publication: 2022 Mar 11.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Brain Neoplasms*/pathology
Glioma*/pathology
Immunologic Deficiency Syndromes*
Cathepsin B/metabolism ; Humans ; Immunosuppression Therapy ; Prognosis ; Promoter Regions, Genetic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
A prostate-specific membrane antigen (PSMA)-targeted prodrug with a favorable in vivo toxicity profile.
Autorzy:
Boinapally S; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Ahn HH; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Cheng B; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Brummet M; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Nam H; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Gabrielson KL; Department of Molecular and Comparative Pathobiology, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Banerjee SR; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Minn I; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD, USA.
Pomper MG; Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD, USA. .
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Źródło:
Scientific reports [Sci Rep] 2021 Mar 29; Vol. 11 (1), pp. 7114. Date of Electronic Publication: 2021 Mar 29.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Aminobenzoates/*pharmacology
Oligopeptides/*pharmacology
Prodrugs/*pharmacology
Prostate-Specific Antigen/*drug effects
Aminobenzoates/administration & dosage ; Aminobenzoates/toxicity ; Animals ; Cathepsin B/metabolism ; Dose-Response Relationship, Drug ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Neoplasm Metastasis/prevention & control ; Oligopeptides/administration & dosage ; Oligopeptides/toxicity ; Prodrugs/administration & dosage ; Prodrugs/toxicity ; Prostatic Neoplasms/pathology ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Characterization of two types of intranuclear hepatocellular inclusions in NAFLD.
Autorzy:
Schwertheim S; Institute of Pathology, University Hospital of Essen, University of Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Germany.
Kälsch J; Institute of Pathology, University Hospital of Essen, University of Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Germany.; Department of Gastroenterology and Hepatology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany.
Jastrow H; Institute of Anatomy and Electron Microscopy Unit of Imaging Center Essen, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany.
Schaefer CM; Institute of Pathology, University Hospital of Essen, University of Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Germany.
Theurer S; Institute of Pathology, University Hospital of Essen, University of Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Germany.
Ting S; Institute of Pathology, University Hospital of Essen, University of Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Germany.
Canbay A; Department of Medicine, Ruhr University Bochum, University Hospital Knappschaftskrankenhaus Bochum, 44892, Bochum, Germany.
Wedemeyer H; Department of Gastroenterology and Hepatology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany.
Schmid KW; Institute of Pathology, University Hospital of Essen, University of Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Germany.; West German Cancer Centre Essen (WTZE), Essen, Germany.
Baba HA; Institute of Pathology, University Hospital of Essen, University of Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Germany. .
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Źródło:
Scientific reports [Sci Rep] 2020 Oct 06; Vol. 10 (1), pp. 16533. Date of Electronic Publication: 2020 Oct 06.
Typ publikacji:
Journal Article
MeSH Terms:
Hepatocytes/*cytology
Intranuclear Inclusion Bodies/*metabolism
Intranuclear Inclusion Bodies/*pathology
Non-alcoholic Fatty Liver Disease/*metabolism
Non-alcoholic Fatty Liver Disease/*pathology
Adult ; Aged ; Autophagy/genetics ; Cathepsin B/metabolism ; Cathepsin D/metabolism ; Disease Progression ; Female ; Humans ; Male ; Microtubule-Associated Proteins/metabolism ; Middle Aged ; Non-alcoholic Fatty Liver Disease/genetics ; Sequestosome-1 Protein/metabolism ; Ubiquitin/metabolism ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cathepsin B overexpression induces degradation of perilipin 1 to cause lipid metabolism dysfunction in adipocytes.
Autorzy:
Mizunoe Y; Department of Internal Medicine (Endocrinology and Metabolism), Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
Kobayashi M; Laboratory of Molecular Pathology & Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan.
Hoshino S; Laboratory of Molecular Pathology & Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan.
Tagawa R; Laboratory of Molecular Pathology & Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan.
Itagawa R; Laboratory of Molecular Pathology & Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan.
Hoshino A; Laboratory of Molecular Pathology & Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan.
Okita N; Department of Pathological Biochemistry, Faculty of Pharmaceutical Sciences, Yamaguchi Tokyo University of Science, Yamaguchi, Japan.
Sudo Y; Laboratory of Molecular Pathology & Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan.
Nakagawa Y; Department of Internal Medicine (Endocrinology and Metabolism), Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan.
Shimano H; Department of Internal Medicine (Endocrinology and Metabolism), Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Japan.; Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Ibaraki, Japan.; AMED-CREST, Japan Agency for Medical Research and Development (AMED), Tokyo, Japan.
Higami Y; Laboratory of Molecular Pathology & Metabolic Disease, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan. .
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Źródło:
Scientific reports [Sci Rep] 2020 Jan 20; Vol. 10 (1), pp. 634. Date of Electronic Publication: 2020 Jan 20.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Gene Expression*
Adipocytes, White/*metabolism
Cathepsin B/*genetics
Cathepsin B/*metabolism
Lipid Metabolism/*genetics
Perilipin-1/*genetics
Perilipin-1/*metabolism
3T3 Cells ; Animals ; Down-Regulation ; Lipolysis/genetics ; Lysosomes/physiology ; Mice
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cell type-dependent pathogenic functions of overexpressed human cathepsin B in murine breast cancer progression.
Autorzy:
Bengsch F; 1] Institute of Molecular Medicine and Cell Research, Albert-Ludwigs-University Freiburg, Freiburg, Germany [2] Spemann Graduate School of Biology and Medicine, Albert-Ludwigs-University Freiburg, Freiburg, Germany [3] Faculty of Biology, Albert-Ludwigs-University Freiburg, Freiburg, Germany.
Buck A; Institute of Molecular Medicine and Cell Research, Albert-Ludwigs-University Freiburg, Freiburg, Germany.
Günther SC; Institute of Molecular Medicine and Cell Research, Albert-Ludwigs-University Freiburg, Freiburg, Germany.
Seiz JR; Institute of Molecular Medicine and Cell Research, Albert-Ludwigs-University Freiburg, Freiburg, Germany.
Tacke M; Institute of Molecular Medicine and Cell Research, Albert-Ludwigs-University Freiburg, Freiburg, Germany.
Pfeifer D; Department of Hematology/Oncology, Genomics Core Lab, University Medical Center, Freiburg, Germany.
von Elverfeldt D; Department of Radiology, Medical Physics, University Medical Center, Freiburg, Germany.
Sevenich L; 1] Institute of Molecular Medicine and Cell Research, Albert-Ludwigs-University Freiburg, Freiburg, Germany [2].
Hillebrand LE; 1] Institute of Molecular Medicine and Cell Research, Albert-Ludwigs-University Freiburg, Freiburg, Germany [2] Faculty of Biology, Albert-Ludwigs-University Freiburg, Freiburg, Germany [3] BIOSS Centre for Biological Signalling Studies, Freiburg, Germany.
Kern U; 1] Institute of Molecular Medicine and Cell Research, Albert-Ludwigs-University Freiburg, Freiburg, Germany [2] Spemann Graduate School of Biology and Medicine, Albert-Ludwigs-University Freiburg, Freiburg, Germany [3] Faculty of Biology, Albert-Ludwigs-University Freiburg, Freiburg, Germany.
Sameni M; Department of Pharmacology, Wayne State University, Detroit, MI, USA.
Peters C; 1] Institute of Molecular Medicine and Cell Research, Albert-Ludwigs-University Freiburg, Freiburg, Germany [2] BIOSS Centre for Biological Signalling Studies, Freiburg, Germany.
Sloane BF; 1] Department of Pharmacology, Wayne State University, Detroit, MI, USA [2] Barbara Ann Carmanos Cancer Institute, Wayne State University, Detroit, MI, USA.
Reinheckel T; 1] Institute of Molecular Medicine and Cell Research, Albert-Ludwigs-University Freiburg, Freiburg, Germany [2] BIOSS Centre for Biological Signalling Studies, Freiburg, Germany.
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Źródło:
Oncogene [Oncogene] 2014 Sep 04; Vol. 33 (36), pp. 4474-84. Date of Electronic Publication: 2013 Sep 30.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Breast Neoplasms/*pathology
Carcinoma, Ductal, Breast/*pathology
Cathepsin B/*metabolism
Extracellular Matrix Proteins/*metabolism
Macrophages/*metabolism
Stromal Cells/*transplantation
Animals ; Antigens, Polyomavirus Transforming/genetics ; Breast Neoplasms/metabolism ; Carcinoma, Ductal, Breast/metabolism ; Cathepsin B/genetics ; Disease Progression ; Doxycycline/pharmacology ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Mammary Neoplasms, Experimental/metabolism ; Mammary Neoplasms, Experimental/pathology ; Mice ; Mice, Transgenic
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Engineering mouse cationic trypsinogen for rapid and selective activation by cathepsin B.
Autorzy:
Demcsák A; Center for Exocrine Disorders, Department of Molecular and Cell Biology, Boston University, Henry M. Goldman School of Dental Medicine, Boston, Massachusetts, 02118, USA.; Department of Surgery, University of California Los Angeles, Los Angeles, California, 90095, USA.
Geisz A; Center for Exocrine Disorders, Department of Molecular and Cell Biology, Boston University, Henry M. Goldman School of Dental Medicine, Boston, Massachusetts, 02118, USA.
Sahin-Tóth M; Center for Exocrine Disorders, Department of Molecular and Cell Biology, Boston University, Henry M. Goldman School of Dental Medicine, Boston, Massachusetts, 02118, USA. .; Department of Surgery, University of California Los Angeles, Los Angeles, California, 90095, USA. .
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Źródło:
Scientific reports [Sci Rep] 2019 Jun 24; Vol. 9 (1), pp. 9188. Date of Electronic Publication: 2019 Jun 24.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Protein Engineering*
Cathepsin B/*metabolism
Cathepsin L/*metabolism
Trypsinogen/*genetics
Animals ; Enzyme Activation ; Humans ; Liver/metabolism ; Mice ; Mutation ; Trypsinogen/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Cathepsin B and uPAR knockdown inhibits tumor-induced angiogenesis by modulating VEGF expression in glioma.
Autorzy:
Malla RR; Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine, Peoria, IL 61605, USA.
Gopinath S
Gondi CS
Alapati K
Dinh DH
Gujrati M
Rao JS
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Źródło:
Cancer gene therapy [Cancer Gene Ther] 2011 Jun; Vol. 18 (6), pp. 419-34. Date of Electronic Publication: 2011 Mar 11.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:
Cathepsin B/*antagonists & inhibitors
Glioma/*blood supply
Glioma/*metabolism
Neovascularization, Pathologic/*metabolism
Receptors, Urokinase Plasminogen Activator/*antagonists & inhibitors
Vascular Endothelial Growth Factor A/*metabolism
Animals ; Cathepsin B/genetics ; Cathepsin B/metabolism ; Cell Line, Tumor ; Genetic Therapy ; Humans ; Mice ; Mice, Nude ; RNA Interference ; RNA, Messenger/metabolism ; Receptors, Urokinase Plasminogen Activator/metabolism
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Transgenic expression of human cathepsin B promotes progression and metastasis of polyoma-middle-T-induced breast cancer in mice.
Autorzy:
Sevenich L; Institute of Molecular Medicine and Cell Research, Albert-Ludwigs-University Freiburg, Freiburg, Germany.
Werner F
Gajda M
Schurigt U
Sieber C
Müller S
Follo M
Peters C
Reinheckel T
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Źródło:
Oncogene [Oncogene] 2011 Jan 06; Vol. 30 (1), pp. 54-64. Date of Electronic Publication: 2010 Sep 06.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cathepsin B/*genetics
Mammary Neoplasms, Experimental/*enzymology
Animals ; Antigens, Polyomavirus Transforming/genetics ; Breast Neoplasms/blood supply ; Breast Neoplasms/enzymology ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Cathepsin B/biosynthesis ; Cathepsin B/metabolism ; Disease Models, Animal ; Disease Progression ; Female ; Humans ; Lung Neoplasms/enzymology ; Lung Neoplasms/secondary ; Mammary Neoplasms, Experimental/blood supply ; Mammary Neoplasms, Experimental/genetics ; Mammary Neoplasms, Experimental/pathology ; Mice ; Mice, Transgenic ; Neovascularization, Pathologic/enzymology ; Neovascularization, Pathologic/pathology
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Long-term exercise training improves memory in middle-aged men and modulates peripheral levels of BDNF and Cathepsin B.
Autorzy:
De la Rosa A; Freshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia and CIBERFES, Fundación Investigación Hospital Clínico Universitario/INCLIVA, Valencia, Spain.
Solana E; Departament de Medicina, Facultat de Medicina, Universitat de Barcelona, and Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Corpas R; Institut d'Investigacions Biomèdiques de Barcelona (IIBB), CSIC, IDIBAPS and CIBERESP, Barcelona, Spain.
Bartrés-Faz D; Departament de Medicina, Facultat de Medicina, Universitat de Barcelona, and Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
Pallàs M; Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia i Ciències de l'Alimentació, Institut de Neurociència, Universitat de Barcelona, Barcelona, Spain.
Vina J; Freshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia and CIBERFES, Fundación Investigación Hospital Clínico Universitario/INCLIVA, Valencia, Spain.
Sanfeliu C; Institut d'Investigacions Biomèdiques de Barcelona (IIBB), CSIC, IDIBAPS and CIBERESP, Barcelona, Spain. .
Gomez-Cabrera MC; Freshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia and CIBERFES, Fundación Investigación Hospital Clínico Universitario/INCLIVA, Valencia, Spain. .
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Źródło:
Scientific reports [Sci Rep] 2019 Mar 04; Vol. 9 (1), pp. 3337. Date of Electronic Publication: 2019 Mar 04.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Exercise*
Memory*
Brain-Derived Neurotrophic Factor/*blood
Cathepsin B/*blood
Adolescent ; Adult ; Aged ; Cognition ; Humans ; Male ; Middle Aged ; Young Adult
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Curcumin inhibits the TGF-β1-dependent differentiation of lung fibroblasts via PPARγ-driven upregulation of cathepsins B and L.
Autorzy:
Saidi A; Université de Tours, Tours, France.; INSERM, UMR 1100, Centre d'Etude des Pathologies Respiratoires (CEPR), Equipe «Mécanismes Protéolytiques dans l'Inflammation», Tours, France.
Kasabova M; Université de Tours, Tours, France.; INSERM, UMR 1100, Centre d'Etude des Pathologies Respiratoires (CEPR), Equipe «Mécanismes Protéolytiques dans l'Inflammation», Tours, France.; Pharmaceutical Product Development, Sofia, Bulgaria.
Vanderlynden L; Université de Tours, Tours, France.; INSERM, UMR 1100, Centre d'Etude des Pathologies Respiratoires (CEPR), Equipe «Mécanismes Protéolytiques dans l'Inflammation», Tours, France.
Wartenberg M; Université de Tours, Tours, France.; INSERM, UMR 1100, Centre d'Etude des Pathologies Respiratoires (CEPR), Equipe «Mécanismes Protéolytiques dans l'Inflammation», Tours, France.
Kara-Ali GH; Université de Tours, Tours, France.; INSERM, UMR 1100, Centre d'Etude des Pathologies Respiratoires (CEPR), Equipe «Mécanismes Protéolytiques dans l'Inflammation», Tours, France.
Marc D; Université de Tours, Tours, France.; INRA, UMR 1282, Infectiologie et Santé publique (ISP), Centre INRA Val de Loire, Nouzilly, France.
Lecaille F; Université de Tours, Tours, France.; INSERM, UMR 1100, Centre d'Etude des Pathologies Respiratoires (CEPR), Equipe «Mécanismes Protéolytiques dans l'Inflammation», Tours, France.
Lalmanach G; Université de Tours, Tours, France. .; INSERM, UMR 1100, Centre d'Etude des Pathologies Respiratoires (CEPR), Equipe «Mécanismes Protéolytiques dans l'Inflammation», Tours, France. .
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Źródło:
Scientific reports [Sci Rep] 2019 Jan 24; Vol. 9 (1), pp. 491. Date of Electronic Publication: 2019 Jan 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cathepsin B/*biosynthesis
Cathepsin L/*biosynthesis
Cell Differentiation/*drug effects
Curcumin/*pharmacology
Gene Expression Regulation, Enzymologic/*drug effects
Lung/*metabolism
PPAR gamma/*metabolism
Transforming Growth Factor beta1/*pharmacology
Up-Regulation/*drug effects
Cell Line ; Humans
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Targeting MMP-9, uPAR, and cathepsin B inhibits invasion, migration and activates apoptosis in prostate cancer cells.
Autorzy:
Nalla AK; Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine, Peoria, IL 61605, USA.
Gorantla B
Gondi CS
Lakka SS
Rao JS
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Źródło:
Cancer gene therapy [Cancer Gene Ther] 2010 Sep; Vol. 17 (9), pp. 599-613. Date of Electronic Publication: 2010 May 07.
Typ publikacji:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis*
Cell Movement*
Cathepsin B/*genetics
Matrix Metalloproteinase 9/*genetics
Prostatic Neoplasms/*pathology
RNA, Small Interfering/*genetics
Receptors, Urokinase Plasminogen Activator/*genetics
Animals ; Blotting, Western ; Cathepsin B/metabolism ; Cell Adhesion ; Cell Line, Tumor ; Cell Proliferation ; Humans ; Male ; Matrix Metalloproteinase 9/metabolism ; Mice ; Mice, Nude ; Prostatic Neoplasms/genetics ; RNA Interference ; RNA, Messenger/genetics ; Receptors, Urokinase Plasminogen Activator/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Down-regulation of cathepsin B expression impairs the invasive and tumorigenic potential of human glioblastoma cells.
Autorzy:
Mohanam S; Division of Cancer Biology, Department of Biomedical and Therapeutic Sciences, University of Illinois College of Medicine at Peoria, 61656, USA.
Jasti SL
Kondraganti SR
Chandrasekar N
Lakka SS
Kin Y
Fuller GN
Yung AW
Kyritsis AP
Dinh DH
Olivero WC
Gujrati M
Ali-Osman F
Rao JS
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Źródło:
Oncogene [Oncogene] 2001 Jun 21; Vol. 20 (28), pp. 3665-73.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, P.H.S.
MeSH Terms:
Down-Regulation*
Neoplasm Invasiveness*
Brain Neoplasms/*pathology
Cathepsin B/*physiology
Glioblastoma/*pathology
Animals ; Blotting, Northern/methods ; Blotting, Western/methods ; Brain/pathology ; Cathepsin B/genetics ; Cathepsin B/metabolism ; Gene Expression ; Humans ; Injections ; Mice ; Mice, Nude ; Neoplasm Transplantation ; RNA, Messenger ; Rats ; Rats, Sprague-Dawley ; Spheroids, Cellular/pathology ; Transfection ; Tumor Cells, Cultured
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Inhibition of cathepsin B and MMP-9 gene expression in glioblastoma cell line via RNA interference reduces tumor cell invasion, tumor growth and angiogenesis.
Autorzy:
Lakka SS; Program of Cancer Biology, Department of Biomedical and Therapeutic Sciences, University of Illinois, Peoria, IL 61656, USA.
Gondi CS
Yanamandra N
Olivero WC
Dinh DH
Gujrati M
Rao JS
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Źródło:
Oncogene [Oncogene] 2004 Jun 10; Vol. 23 (27), pp. 4681-9.
Typ publikacji:
Journal Article; Research Support, U.S. Gov't, P.H.S.
MeSH Terms:
Gene Expression Regulation, Neoplastic*
RNA Interference*
Cathepsin B/*antagonists & inhibitors
Glioblastoma/*metabolism
Matrix Metalloproteinase 9/*metabolism
Animals ; Blotting, Western ; Cathepsin B/administration & dosage ; Cell Division/genetics ; Cell Line, Tumor ; Cell Movement/genetics ; Collagen/metabolism ; Down-Regulation ; Drug Combinations ; Glioblastoma/blood supply ; Glioblastoma/genetics ; Glioblastoma/pathology ; Humans ; Injections, Intraperitoneal ; Injections, Intraventricular ; Laminin/metabolism ; Matrix Metalloproteinase 9/administration & dosage ; Mice ; Mice, Nude ; Models, Biological ; Neoplasm Invasiveness ; Neoplasm Transplantation ; Neovascularization, Pathologic/genetics ; Proteoglycans/metabolism ; Spheroids, Cellular ; Transplantation, Heterologous
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Critical role for cathepsin B in mediating caspase-1-dependent interleukin-18 maturation and caspase-1-independent necrosis triggered by the microbial toxin nigericin.
Autorzy:
Hentze H; Institute of Molecular and Cell Biology, Singapore, Republic of Singapore.
Lin XY
Choi MS
Porter AG
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Źródło:
Cell death and differentiation [Cell Death Differ] 2003 Sep; Vol. 10 (9), pp. 956-68.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Necrosis*
Bacterial Toxins/*pharmacology
Caspase 1/*metabolism
Cathepsin B/*physiology
Interleukin-18/*metabolism
Monocytes/*immunology
Nigericin/*pharmacology
Animals ; Bacterial Toxins/antagonists & inhibitors ; Calpain/metabolism ; Cathepsin B/antagonists & inhibitors ; Cell Line ; Cells, Cultured ; Cysteine Proteinase Inhibitors/pharmacology ; Dipeptides/pharmacology ; Interleukin-18/biosynthesis ; Lipopolysaccharides/pharmacology ; Macrophages/drug effects ; Macrophages/immunology ; Mice ; Monocytes/cytology ; Monocytes/drug effects ; Monocytes/enzymology ; Nigericin/antagonists & inhibitors ; Protein Transport/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The relationship between vacuolation and initiation of PCD in rice (Oryza sativa) aleurone cells.
Autorzy:
Zheng Y; Key Laboratory of Protection and Development Utilization of Tropical Crop Germplasm Resources (Hainan University), Ministry of Education, Haikou 570228, China.; College of Horticulture and Landscape Architecture, Hainan University, Haikou 570228, China.
Zhang H; Key Laboratory of Protection and Development Utilization of Tropical Crop Germplasm Resources (Hainan University), Ministry of Education, Haikou 570228, China.; College of Horticulture and Landscape Architecture, Hainan University, Haikou 570228, China.
Deng X; Key Laboratory of Protection and Development Utilization of Tropical Crop Germplasm Resources (Hainan University), Ministry of Education, Haikou 570228, China.; College of Horticulture and Landscape Architecture, Hainan University, Haikou 570228, China.
Liu J; Key Laboratory of Protection and Development Utilization of Tropical Crop Germplasm Resources (Hainan University), Ministry of Education, Haikou 570228, China.; College of Horticulture and Landscape Architecture, Hainan University, Haikou 570228, China.
Chen H; Key Laboratory of Protection and Development Utilization of Tropical Crop Germplasm Resources (Hainan University), Ministry of Education, Haikou 570228, China.; College of Horticulture and Landscape Architecture, Hainan University, Haikou 570228, China.
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Źródło:
Scientific reports [Sci Rep] 2017 Jan 24; Vol. 7, pp. 41245. Date of Electronic Publication: 2017 Jan 24.
Typ publikacji:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Apoptosis*/drug effects
Oryza/*cytology
Oryza/*metabolism
Vacuoles/*metabolism
Actin Cytoskeleton/metabolism ; Amino Acid Chloromethyl Ketones/pharmacology ; Cathepsin B/antagonists & inhibitors ; Cathepsin B/metabolism ; Cell Membrane/metabolism ; Cell Nucleus/drug effects ; Cell Nucleus/metabolism ; Cell Nucleus Shape/drug effects ; Cysteine Endopeptidases/metabolism ; Cytochalasin B/pharmacology ; Membrane Fusion/drug effects ; Oryza/drug effects ; Permeability ; Phalloidine/pharmacology ; Protoplasts/drug effects ; Protoplasts/metabolism ; Seeds/cytology ; Seeds/metabolism ; Vacuoles/drug effects
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknieSzczegóły
Wyświetlanie 1-20 z 130

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