Informacja

Drogi użytkowniku, aplikacja do prawidłowego działania wymaga obsługi JavaScript. Proszę włącz obsługę JavaScript w Twojej przeglądarce.

Przeglądasz jako GOŚĆ

Wyszukujesz frazę ""Cathepsin D"" wg kryterium: Temat


Tytuł :
Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling.
Autorzy :
Ketterer S; Institute of Molecular Medicine and Cell Research, University of Freiburg, Freiburg, 79104, Germany.; Faculty of Biology, University of Freiburg, Freiburg, 79104, Germany.; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), partner site Freiburg, Freiburg, 79104, Germany.
Mitschke J; Institute of Molecular Medicine and Cell Research, University of Freiburg, Freiburg, 79104, Germany.
Ketscher A; Institute of Molecular Medicine and Cell Research, University of Freiburg, Freiburg, 79104, Germany.
Schlimpert M; Faculty of Biology, University of Freiburg, Freiburg, 79104, Germany.; Spemann Graduate School of Biology and Medicine, University of Freiburg, Freiburg, 79104, Germany.; Centre for Integrative Signalling Analysis (CISA), University of Freiburg, Freiburg, 79104, Germany.
Reichardt W; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), partner site Freiburg, Freiburg, 79104, Germany.; Medical Physics, Department of Radiology, University Medical Center Freiburg, Freiburg, 79106, Germany.
Baeuerle N; Institute of Molecular Medicine and Cell Research, University of Freiburg, Freiburg, 79104, Germany.
Hess ME; Institute of Molecular Medicine and Cell Research, University of Freiburg, Freiburg, 79104, Germany.; Faculty of Biology, University of Freiburg, Freiburg, 79104, Germany.; Institute of Medical Bioinformatics and Systems Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, 79110, Germany.; Comprehensive Cancer Center Freiburg (CCCF), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, 79106, Germany.
Metzger P; Institute of Molecular Medicine and Cell Research, University of Freiburg, Freiburg, 79104, Germany.; Faculty of Biology, University of Freiburg, Freiburg, 79104, Germany.; Institute of Medical Bioinformatics and Systems Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, 79110, Germany.
Boerries M; Institute of Molecular Medicine and Cell Research, University of Freiburg, Freiburg, 79104, Germany.; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), partner site Freiburg, Freiburg, 79104, Germany.; Institute of Medical Bioinformatics and Systems Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, 79110, Germany.; Comprehensive Cancer Center Freiburg (CCCF), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, 79106, Germany.
Peters C; Institute of Molecular Medicine and Cell Research, University of Freiburg, Freiburg, 79104, Germany.; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), partner site Freiburg, Freiburg, 79104, Germany.; Comprehensive Cancer Center Freiburg (CCCF), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, 79106, Germany.; BIOSS Centre for Biological Signalling Studies, University of Freiburg, Freiburg, 79104, Germany.
Kammerer B; Centre for Integrative Signalling Analysis (CISA), University of Freiburg, Freiburg, 79104, Germany.; BIOSS Centre for Biological Signalling Studies, University of Freiburg, Freiburg, 79104, Germany.
Brummer T; Institute of Molecular Medicine and Cell Research, University of Freiburg, Freiburg, 79104, Germany.; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), partner site Freiburg, Freiburg, 79104, Germany.; BIOSS Centre for Biological Signalling Studies, University of Freiburg, Freiburg, 79104, Germany.
Steinberg F; Centre for Integrative Signalling Analysis (CISA), University of Freiburg, Freiburg, 79104, Germany.
Reinheckel T; Institute of Molecular Medicine and Cell Research, University of Freiburg, Freiburg, 79104, Germany. .; German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), partner site Freiburg, Freiburg, 79104, Germany. .; Comprehensive Cancer Center Freiburg (CCCF), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, 79106, Germany. .; BIOSS Centre for Biological Signalling Studies, University of Freiburg, Freiburg, 79104, Germany. .
Pokaż więcej
Źródło :
Nature communications [Nat Commun] 2020 Oct 12; Vol. 11 (1), pp. 5133. Date of Electronic Publication: 2020 Oct 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Breast Neoplasms/*metabolism
Cathepsin D/*genetics
Epithelium/*metabolism
Mechanistic Target of Rapamycin Complex 1/*metabolism
Animals ; Breast Neoplasms/genetics ; Cathepsin D/deficiency ; Female ; Humans ; Mammary Glands, Animal/metabolism ; Mechanistic Target of Rapamycin Complex 1/genetics ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Knockout ; Signal Transduction
Czasopismo naukowe
Tytuł :
Grassystatin-derived peptides selectively inhibit cathepsin E and have low affinity to cathepsin D.
Autorzy :
Stotz S; Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University, Tübingen, Germany; iFIT Cluster of Excellence, Eberhard Karls University, Tübingen, Germany.
Bleher D; Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University, Tübingen, Germany.
Kalbacher H; Interfaculty Institute of Biochemistry, Eberhard Karls University, Tübingen, Germany.
Maurer A; Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University, Tübingen, Germany; iFIT Cluster of Excellence, Eberhard Karls University, Tübingen, Germany; Interfaculty Institute of Biochemistry, Eberhard Karls University, Tübingen, Germany. Electronic address: .
Pokaż więcej
Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Jun 18; Vol. 527 (1), pp. 238-241. Date of Electronic Publication: 2020 May 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cathepsin D/*antagonists & inhibitors
Cathepsin E/*antagonists & inhibitors
Enzyme Inhibitors/*pharmacology
Peptides/*pharmacology
Cathepsin D/metabolism ; Cathepsin E/metabolism ; Dose-Response Relationship, Drug ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; HEK293 Cells ; Humans ; Molecular Structure ; Peptides/chemical synthesis ; Peptides/chemistry ; Recombinant Proteins/metabolism ; Stereoisomerism ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Inhibition of Cathepsin D (CTSD) enhances radiosensitivity of glioblastoma cells by attenuating autophagy.
Autorzy :
Zheng W; Department of Radiation Biology, Institute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai, China.
Chen Q; Department of Radiation Biology, Institute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai, China.
Wang C; Department of Radiation Biology, Institute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai, China.
Yao D; Department of Radiation Biology, Institute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai, China.
Zhu L; Department of Radiation Biology, Institute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai, China.
Pan Y; Department of Radiation Biology, Institute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai, China.
Zhang J; Department of Radiation Biology, Institute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai, China.
Bai Y; Department of Radiation Biology, Institute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai, China.
Shao C; Department of Radiation Biology, Institute of Radiation Medicine, Shanghai Medical College, Fudan University, Shanghai, China.
Pokaż więcej
Źródło :
Molecular carcinogenesis [Mol Carcinog] 2020 Jun; Vol. 59 (6), pp. 651-660. Date of Electronic Publication: 2020 Apr 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autophagy*
Brain Neoplasms/*radiotherapy
Cathepsin D/*antagonists & inhibitors
Gene Expression Regulation, Neoplastic/*radiation effects
Glioblastoma/*radiotherapy
RNA, Small Interfering/*genetics
Radiation Tolerance/*genetics
Apoptosis ; Biomarkers, Tumor/genetics ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Cathepsin D/genetics ; Cell Proliferation ; Glioblastoma/metabolism ; Glioblastoma/pathology ; Humans ; Prognosis ; Radiation, Ionizing ; Survival Rate ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Schistosoma mansoni cathepsin D1: Biochemical and biophysical characterization of the recombinant enzyme expressed in HEK293T cells.
Autorzy :
Araujo-Montoya BO; Laboratório de Bioquímica Experimental e Computacional de Fármacos, LaBECFar, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Avenida Brasil 4365, CEP 21040-360, Rio de Janeiro, RJ, Brazil.
Senger MR; Laboratório de Bioquímica Experimental e Computacional de Fármacos, LaBECFar, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Avenida Brasil 4365, CEP 21040-360, Rio de Janeiro, RJ, Brazil.
Gomes BF; Laboratório de Bioquímica Experimental e Computacional de Fármacos, LaBECFar, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Avenida Brasil 4365, CEP 21040-360, Rio de Janeiro, RJ, Brazil.
Harris G; Research Complex at Harwell, R92 Rutherford Appleton Laboratory, Didcot, OX11 0FA, UK.
Owens RJ; Research Complex at Harwell, R92 Rutherford Appleton Laboratory, Didcot, OX11 0FA, UK; The Division of Structural Biology, Henry Wellcome Building for Genomic Medicine, Roosevelt Drive, Oxford, OX3 7BN, UK.
Silva-Jr FP; Laboratório de Bioquímica Experimental e Computacional de Fármacos, LaBECFar, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Avenida Brasil 4365, CEP 21040-360, Rio de Janeiro, RJ, Brazil. Electronic address: .
Pokaż więcej
Źródło :
Protein expression and purification [Protein Expr Purif] 2020 Mar; Vol. 167, pp. 105532. Date of Electronic Publication: 2019 Nov 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cathepsin D/*isolation & purification
Schistosoma mansoni/*enzymology
Animals ; Aspartic Acid Proteases/biosynthesis ; Aspartic Acid Proteases/chemistry ; Aspartic Acid Proteases/isolation & purification ; Aspartic Acid Proteases/metabolism ; Cathepsin D/biosynthesis ; Cathepsin D/chemistry ; Cathepsin D/metabolism ; Cathepsins/biosynthesis ; Cathepsins/chemistry ; Cathepsins/isolation & purification ; Cathepsins/metabolism ; Chromatography, Gel ; Dimerization ; HEK293 Cells ; Humans ; Kinetics ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/chemistry ; Recombinant Proteins/isolation & purification ; Recombinant Proteins/metabolism ; Ultracentrifugation/methods
Czasopismo naukowe
Tytuł :
Antiproliferative and Antimetastatic Effects of Praeruptorin C on Human Non-Small Cell Lung Cancer Through Inactivating ERK/CTSD Signalling Pathways.
Autorzy :
Liu CM; Department of Pulmonary Medicine, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung 40427, Taiwan.
Shen HT; Department of Pulmonary Medicine, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taichung 40427, Taiwan.; Institute of Biochemistry, Microbiology, and Immunology, Chung Shan Medical, Taichung 40201, Taiwan.
Lin YA; Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung 40201, Taiwan.
Yu YL; Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan.; Center for Molecular Medicine, China Medical University Hospital, Taichung 40402, Taiwan.; Department of Biotechnology, Asia University, Taichung 40402, Taiwan.
Chen YS; Institute of Biochemistry, Microbiology, and Immunology, Chung Shan Medical, Taichung 40201, Taiwan.
Liu CJ; Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.; Regenetative Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Hsieh YH; Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.; Department of Biochemistry, School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.; Clinical laboratory, Chung Shan Medical University Hospital, Taichung 40201, Taiwan.
Pokaż więcej
Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Apr 01; Vol. 25 (7). Date of Electronic Publication: 2020 Apr 01.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents, Phytogenic/*pharmacology
Carcinoma, Non-Small-Cell Lung/*metabolism
Cathepsin D/*metabolism
Coumarins/*pharmacology
Extracellular Signal-Regulated MAP Kinases/*metabolism
Lung Neoplasms/*metabolism
Signal Transduction/*drug effects
Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/pathology ; Cathepsin D/genetics ; Cell Cycle Checkpoints/drug effects ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Cell Survival ; Drugs, Chinese Herbal ; Gene Expression Regulation ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/pathology ; Neoplasm Metastasis
Czasopismo naukowe
Tytuł :
Matrix Metalloproteases and Cathepsin D in Human Serum do not Cleave Prolactin to Generate Vasoinhibin.
Autorzy :
Triebel J
Schauer N
Zamora M
Moreno-Vega AI
Escalera GM
Clapp C
Bertsch T
Pokaż więcej
Źródło :
Clinical laboratory [Clin Lab] 2020 May 01; Vol. 66 (5).
Typ publikacji :
Journal Article
MeSH Terms :
Cathepsin D/*metabolism
Cell Cycle Proteins/*metabolism
Matrix Metalloproteinases/*metabolism
Prolactin/*metabolism
Adult ; Aged, 80 and over ; Cathepsin D/blood ; Cell Cycle Proteins/blood ; Diabetes Mellitus, Type 2/metabolism ; Female ; Humans ; Male ; Matrix Metalloproteinases/blood ; Middle Aged ; Prolactin/blood ; Proteolysis
Czasopismo naukowe
Tytuł :
Myocardial cathepsin D is downregulated in sudden cardiac death.
Autorzy :
Kakimoto Y; Department of Forensic Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
Sasaki A; Support Center for Medical Research and Education, Tokai University, Tokyo, Kanagawa, Japan.
Niioka M; Support Center for Medical Research and Education, Tokai University, Tokyo, Kanagawa, Japan.
Kawabe N; Support Center for Medical Research and Education, Tokai University, Tokyo, Kanagawa, Japan.
Osawa M; Department of Forensic Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
Pokaż więcej
Źródło :
PloS one [PLoS One] 2020 Mar 16; Vol. 15 (3), pp. e0230375. Date of Electronic Publication: 2020 Mar 16 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Death, Sudden, Cardiac*
Down-Regulation*
Cathepsin D/*metabolism
Myocardium/*metabolism
Adult ; Aged ; Aged, 80 and over ; Aging/metabolism ; Cathepsin D/blood ; Female ; Humans ; Male ; Middle Aged ; Myocardium/pathology ; Substrate Specificity
Czasopismo naukowe
Tytuł :
Hyperglycemia-induced cardiomyocyte death is mediated by lysosomal membrane injury and aberrant expression of cathepsin D.
Autorzy :
Kobayashi S; Department of Biomedical Sciences, New York Institute of Technology, College of Osteopathic Medicine, Old Westbury, New York, 11568, USA. Electronic address: .
Zhao F; Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong University Health Science Center, Xi' an, China.
Kobayashi T; Department of Biomedical Sciences, New York Institute of Technology, College of Osteopathic Medicine, Old Westbury, New York, 11568, USA.
Hagiwara M; Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, 52242, USA.
Kaminaris A; Department of Biomedical Sciences, New York Institute of Technology, College of Osteopathic Medicine, Old Westbury, New York, 11568, USA.
Li C; Clinical Medical College, Hubei University of Science and Technology, Xianning, China.
Cai F; Clinical Medical College, Hubei University of Science and Technology, Xianning, China.
Huang Y; Department of Biomedical Sciences, New York Institute of Technology, College of Osteopathic Medicine, Old Westbury, New York, 11568, USA.
Liang Q; Department of Biomedical Sciences, New York Institute of Technology, College of Osteopathic Medicine, Old Westbury, New York, 11568, USA.
Pokaż więcej
Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2020 Feb 26; Vol. 523 (1), pp. 239-245. Date of Electronic Publication: 2019 Dec 18.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Death*
Cathepsin D/*metabolism
Hyperglycemia/*metabolism
Hyperglycemia/*pathology
Lysosomes/*metabolism
Lysosomes/*pathology
Myocytes, Cardiac/*metabolism
Animals ; Cathepsin D/antagonists & inhibitors ; Cathepsin D/genetics ; Cells, Cultured ; Humans ; Hydrogen-Ion Concentration ; Microscopy, Fluorescence ; Myocytes, Cardiac/pathology ; RNA, Small Interfering/pharmacology ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
A Novel Dual Fluorochrome Near-Infrared Imaging Probe for Potential Alzheimer's Enzyme Biomarkers-BACE1 and Cathepsin D.
Autorzy :
Tam JM; Wyss Institute and Harvard Medical School, Boston, MA 02115, USA.
Josephson L; Center for Molecular Imaging Research (CMIR), Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Pilozzi AR; Neurochemistry Laboratory, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Huang X; Neurochemistry Laboratory, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA.
Pokaż więcej
Źródło :
Molecules (Basel, Switzerland) [Molecules] 2020 Jan 09; Vol. 25 (2). Date of Electronic Publication: 2020 Jan 09.
Typ publikacji :
Journal Article
MeSH Terms :
Molecular Imaging*
Alzheimer Disease/*diagnosis
Amyloid Precursor Protein Secretases/*chemistry
Aspartic Acid Endopeptidases/*chemistry
Cathepsin D/*chemistry
Alzheimer Disease/genetics ; Amino Acid Sequence/genetics ; Amyloid Precursor Protein Secretases/genetics ; Amyloid Precursor Protein Secretases/isolation & purification ; Amyloid beta-Protein Precursor/chemistry ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/isolation & purification ; Aspartic Acid Endopeptidases/genetics ; Aspartic Acid Endopeptidases/isolation & purification ; Biomarkers/chemistry ; Cathepsin D/genetics ; Cathepsin D/isolation & purification ; Fluorescent Dyes/chemistry ; Fluorescent Dyes/isolation & purification ; Humans
Czasopismo naukowe
Tytuł :
Partial Characterization of Two Cathepsin D Family Aspartic Peptidases of Clonorchis sinensis.
Autorzy :
Kang JM; Department of Parasitology and Tropical Medicine, and Institute of Health Sciences, Gyeongsang National University College of Medicine, Jinju 52727, Korea.; BK21Plus Team for Anti-aging Biotechnology and Industry, Department of Convergence Medical Science, Gyeongsang National University, Jinju 52727, Korea.
Yoo WG; Department of Medical Environmental Biology, Chung-Ang University College of Medicine, Seoul 06974, Korea.
Lê HG; Department of Parasitology and Tropical Medicine, and Institute of Health Sciences, Gyeongsang National University College of Medicine, Jinju 52727, Korea.; BK21Plus Team for Anti-aging Biotechnology and Industry, Department of Convergence Medical Science, Gyeongsang National University, Jinju 52727, Korea.
Thái TL; Department of Parasitology and Tropical Medicine, and Institute of Health Sciences, Gyeongsang National University College of Medicine, Jinju 52727, Korea.; BK21Plus Team for Anti-aging Biotechnology and Industry, Department of Convergence Medical Science, Gyeongsang National University, Jinju 52727, Korea.
Hong SJ; Department of Medical Environmental Biology, Chung-Ang University College of Medicine, Seoul 06974, Korea.
Sohn WM; Department of Parasitology and Tropical Medicine, and Institute of Health Sciences, Gyeongsang National University College of Medicine, Jinju 52727, Korea.
Na BK
Pokaż więcej
Źródło :
The Korean journal of parasitology [Korean J Parasitol] 2019 Dec; Vol. 57 (6), pp. 671-680. Date of Electronic Publication: 2019 Dec 31.
Typ publikacji :
Journal Article
MeSH Terms :
Cathepsin D/*chemistry
Clonorchiasis/*parasitology
Clonorchis sinensis/*enzymology
Helminth Proteins/*chemistry
Amino Acid Sequence ; Animals ; Cathepsin D/genetics ; Cathepsin D/metabolism ; Cloning, Molecular ; Clonorchis sinensis/chemistry ; Clonorchis sinensis/genetics ; Female ; Helminth Proteins/genetics ; Helminth Proteins/metabolism ; Humans ; Male ; Rats ; Rats, Sprague-Dawley ; Sequence Alignment
Czasopismo naukowe
Tytuł :
Biomimetic Macrocyclic Inhibitors of Human Cathepsin D: Structure-Activity Relationship and Binding Mode Analysis.
Autorzy :
Houštecká R; Institute of Organic Chemistry and Biochemistry , Czech Academy of Sciences , Flemingovo nám. 2 , 16610 Praha 6 , Czech Republic.; First Faculty of Medicine , Charles University , Kateřinská 32 , 12108 Praha 2 , Czech Republic.
Hadzima M; Institute of Organic Chemistry and Biochemistry , Czech Academy of Sciences , Flemingovo nám. 2 , 16610 Praha 6 , Czech Republic.; Department of Organic Chemistry, Faculty of Science , Charles University , Albertov 6 , 12800 Praha 2 , Czech Republic.
Fanfrlík J; Institute of Organic Chemistry and Biochemistry , Czech Academy of Sciences , Flemingovo nám. 2 , 16610 Praha 6 , Czech Republic.
Brynda J; Institute of Organic Chemistry and Biochemistry , Czech Academy of Sciences , Flemingovo nám. 2 , 16610 Praha 6 , Czech Republic.
Pallová L; Institute of Organic Chemistry and Biochemistry , Czech Academy of Sciences , Flemingovo nám. 2 , 16610 Praha 6 , Czech Republic.
Hánová I; Institute of Organic Chemistry and Biochemistry , Czech Academy of Sciences , Flemingovo nám. 2 , 16610 Praha 6 , Czech Republic.; Department of Biochemistry, Faculty of Science , Charles University , Albertov 6 , 12800 Praha 2 , Czech Republic.
Mertlíková-Kaiserová H; Institute of Organic Chemistry and Biochemistry , Czech Academy of Sciences , Flemingovo nám. 2 , 16610 Praha 6 , Czech Republic.
Lepšík M; Institute of Organic Chemistry and Biochemistry , Czech Academy of Sciences , Flemingovo nám. 2 , 16610 Praha 6 , Czech Republic.
Horn M; Institute of Organic Chemistry and Biochemistry , Czech Academy of Sciences , Flemingovo nám. 2 , 16610 Praha 6 , Czech Republic.
Smrčina M; Tucson Research Center , Icagen Inc. , 2090 E. Innovation Park Drive , Oro Valley , Arizona 85755 , United States.
Majer P; Institute of Organic Chemistry and Biochemistry , Czech Academy of Sciences , Flemingovo nám. 2 , 16610 Praha 6 , Czech Republic.
Mareš M; Institute of Organic Chemistry and Biochemistry , Czech Academy of Sciences , Flemingovo nám. 2 , 16610 Praha 6 , Czech Republic.
Pokaż więcej
Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Feb 27; Vol. 63 (4), pp. 1576-1596. Date of Electronic Publication: 2020 Feb 13.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cathepsin D/*antagonists & inhibitors
Cathepsin D/*metabolism
Peptides, Cyclic/*chemistry
Peptides, Cyclic/*metabolism
Protease Inhibitors/*chemistry
Protease Inhibitors/*metabolism
Binding Sites ; Biomimetic Materials/chemical synthesis ; Biomimetic Materials/chemistry ; Biomimetic Materials/metabolism ; Biomimetic Materials/toxicity ; Caco-2 Cells ; Cathepsin D/chemistry ; Enzyme Assays ; Humans ; Kinetics ; Molecular Structure ; Pepstatins/chemistry ; Peptides, Cyclic/chemical synthesis ; Peptides, Cyclic/toxicity ; Protease Inhibitors/chemical synthesis ; Protease Inhibitors/toxicity ; Protein Binding ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Investigation of three enzymes and their roles in the embryonic development of parthenogenetic Haemaphysalis longicornis.
Autorzy :
Qiu ZX; Hebei Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology, College of Life Sciences, Hebei Normal University, Shijiazhuang, 050024, China.
Li Y; Hebei Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology, College of Life Sciences, Hebei Normal University, Shijiazhuang, 050024, China.
Li MM; Hebei Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology, College of Life Sciences, Hebei Normal University, Shijiazhuang, 050024, China.
Wang WY; Hebei Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology, College of Life Sciences, Hebei Normal University, Shijiazhuang, 050024, China.
Zhang TT; Hebei Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology, College of Life Sciences, Hebei Normal University, Shijiazhuang, 050024, China.
Liu JZ; Hebei Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology, College of Life Sciences, Hebei Normal University, Shijiazhuang, 050024, China. .
Pokaż więcej
Źródło :
Parasites & vectors [Parasit Vectors] 2020 Jan 31; Vol. 13 (1), pp. 46. Date of Electronic Publication: 2020 Jan 31.
Typ publikacji :
Journal Article
MeSH Terms :
Acid Phosphatase/*metabolism
Arachnid Vectors/*embryology
Cathepsin B/*metabolism
Cathepsin D/*metabolism
Ixodidae/*embryology
Parthenogenesis/*physiology
Acid Phosphatase/genetics ; Animals ; Arachnid Vectors/enzymology ; Arachnid Vectors/physiology ; Cathepsin B/genetics ; Cathepsin D/genetics ; Cloning, Molecular ; Embryonic Development ; Female ; Gene Silencing ; Ixodidae/enzymology ; Ixodidae/physiology ; Oviposition/physiology ; RNA Interference/physiology ; RNA, Double-Stranded/physiology ; RNA, Messenger/metabolism ; Rabbits ; Real-Time Polymerase Chain Reaction ; Time Factors ; Vitellins/metabolism
Czasopismo naukowe
Tytuł :
Cathepsin D in the Tumor Microenvironment of Breast and Ovarian Cancers.
Autorzy :
Pranjol ZI; School of Life Sciences, University of Sussex, Falmer, Brighton, UK. .
Whatmore JL; Institute of Biomedical and Clinical Science, University of Exeter Medical School, Exeter, Devon, UK.
Pokaż więcej
Źródło :
Advances in experimental medicine and biology [Adv Exp Med Biol] 2020; Vol. 1259, pp. 1-16.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Cathepsin D*/antagonists & inhibitors
Tumor Microenvironment*/drug effects
Breast Neoplasms/*pathology
Ovarian Neoplasms/*pathology
Animals ; Breast Neoplasms/drug therapy ; Female ; Humans ; Ovarian Neoplasms/drug therapy ; Quality of Life
Czasopismo naukowe
Tytuł :
Comprehensive Exploration of Target-specific Ligands Using a Graph Convolution Neural Network.
Autorzy :
Miyazaki Y; Division of Information Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara, 630-0192, Japan.
Ono N; Division of Information Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara, 630-0192, Japan.; Data Science Center, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara, 630-0192, Japan.
Huang M; Division of Information Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara, 630-0192, Japan.
Altaf-Ul-Amin M; Division of Information Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara, 630-0192, Japan.
Kanaya S; Division of Information Science, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara, 630-0192, Japan.; Data Science Center, Graduate School of Science and Technology, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara, 630-0192, Japan.
Pokaż więcej
Źródło :
Molecular informatics [Mol Inform] 2020 Jan; Vol. 39 (1-2), pp. e1900095. Date of Electronic Publication: 2019 Dec 09.
Typ publikacji :
Journal Article
MeSH Terms :
Algorithms*
Neural Networks, Computer*
Amyloid Precursor Protein Secretases/*chemistry
Aspartic Acid Endopeptidases/*chemistry
Cathepsin D/*chemistry
Amyloid Precursor Protein Secretases/antagonists & inhibitors ; Aspartic Acid Endopeptidases/antagonists & inhibitors ; Cathepsin D/pharmacology ; Humans ; Ligands
Czasopismo naukowe
Tytuł :
Expression of cathepsins B, D and K in thymic epithelial tumours.
Autorzy :
Yamaguchi N; Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.; Comprehensive Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Tomaru U; Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan .
Kiuchi T; Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Ishizu A; Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Sapporo, Japan.
Deguchi T; Surgical Pathology, Hokkaido University Hospital, Sapporo, Japan.
Otsuka N; Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Tanaka S; Center for Cause of Death Investigation, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Marukawa K; Surgical Pathology, Hokkaido University Hospital, Sapporo, Japan.; Clinical Laboratory Science, School of Medical Technology, Health Sciences University of Hokkaido, Sapporo, Japan.
Matsuno Y; Surgical Pathology, Hokkaido University Hospital, Sapporo, Japan.
Kitagawa M; Comprehensive Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Kasahara M; Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Pokaż więcej
Źródło :
Journal of clinical pathology [J Clin Pathol] 2021 Feb; Vol. 74 (2), pp. 84-90. Date of Electronic Publication: 2020 May 28.
Typ publikacji :
Journal Article
MeSH Terms :
Biomarkers, Tumor/*metabolism
Cathepsin B/*biosynthesis
Cathepsin D/*biosynthesis
Cathepsin K/*biosynthesis
Neoplasms, Glandular and Epithelial/*pathology
Thymus Neoplasms/*pathology
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor/analysis ; Female ; Humans ; Male ; Middle Aged ; Neoplasms, Glandular and Epithelial/metabolism ; Thymus Neoplasms/metabolism ; Young Adult
SCR Disease Name :
Thymic epithelial tumor
Czasopismo naukowe
Tytuł :
Complement receptor 3 mediates ruffle-like, actin-rich aggregates during phagocytosis of Leishmania infantum metacyclics.
Autorzy :
Dixit UG; Department of Internal Medicine, University of Iowa, Iowa City, IA, 52242, USA.
Rodríguez NE; Department of Biology, University of Northern Iowa, Cedar Falls, IA, 50614, USA. Electronic address: .
Polando R; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, 46556, USA.
McDowell MA; Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, 46556, USA.
Wilson ME; Department of Internal Medicine, University of Iowa, Iowa City, IA, 52242, USA; Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, 52242, USA; Veterans' Affairs Medical Center, Iowa City, IA, 52242, USA.
Pokaż więcej
Źródło :
Experimental parasitology [Exp Parasitol] 2021 Jan; Vol. 220, pp. 107968. Date of Electronic Publication: 2020 Aug 08.
Typ publikacji :
Journal Article
MeSH Terms :
Actins/*metabolism
Leishmania infantum/*physiology
Leishmaniasis, Visceral/*parasitology
Macrophage-1 Antigen/*physiology
Phagocytosis/*physiology
Animals ; Cathepsin D/metabolism ; Cell Membrane/ultrastructure ; Cricetinae ; Humans ; Leishmania infantum/pathogenicity ; Leishmania infantum/ultrastructure ; Lysosomal-Associated Membrane Protein 1/metabolism ; Macrophages/parasitology ; Male ; Mesocricetus ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Microscopy, Confocal ; Vacuoles/parasitology ; Virulence
Czasopismo naukowe
Tytuł :
Extraction of Cathepsin D-Like Protease from Neon Flying Squid ( Ommastrephes bartramii ) Viscera and Application in Antioxidant Hydrolysate Production.
Autorzy :
Zhang K; School of Food Science and Pharmacy, Zhejiang Ocean University, Zhoushan 316000, China. .
Wei R; School of Marine Science and Technology, Zhejiang Ocean University, Zhoushan 316022, China. .
Song R; School of Food Science and Pharmacy, Zhejiang Ocean University, Zhoushan 316000, China. .
Pokaż więcej
Źródło :
Biomolecules [Biomolecules] 2019 Jun 12; Vol. 9 (6). Date of Electronic Publication: 2019 Jun 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antioxidants/*metabolism
Cathepsin D/*isolation & purification
Cathepsin D/*metabolism
Cephalopoda/*enzymology
Viscera/*enzymology
Amino Acid Sequence ; Animals ; Cathepsin D/chemistry ; Enzyme Stability ; Filtration ; Hydrogen-Ion Concentration ; Hydrolysis ; Membranes, Artificial ; Solubility ; Substrate Specificity
Czasopismo naukowe
Tytuł :
[Gly14]-humanin restores cathepsin D function via FPRL1 and promotes autophagic degradation of Ox-LDL in HUVECs.
Autorzy :
Ding Y; Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China; Institute of Neuroscience, Soochow University, Suzhou, 215123, China.
Feng Y; Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Zou Y; Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Wang F; Institute of Neuroscience, Soochow University, Suzhou, 215123, China.
Liu H; Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
Liu C; Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China; Institute of Neuroscience, Soochow University, Suzhou, 215123, China. Electronic address: .
Zhang Y; Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China. Electronic address: .
Pokaż więcej
Źródło :
Nutrition, metabolism, and cardiovascular diseases : NMCD [Nutr Metab Cardiovasc Dis] 2020 Nov 27; Vol. 30 (12), pp. 2406-2416. Date of Electronic Publication: 2020 Jul 25.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Autophagy/*drug effects
Cathepsin D/*metabolism
Human Umbilical Vein Endothelial Cells/*drug effects
Lipoproteins, LDL/*metabolism
Lysosomes/*drug effects
Peptides/*pharmacology
Receptors, Formyl Peptide/*metabolism
Receptors, Lipoxin/*metabolism
Cells, Cultured ; Human Umbilical Vein Endothelial Cells/enzymology ; Human Umbilical Vein Endothelial Cells/pathology ; Humans ; Lysosomes/enzymology ; Lysosomes/pathology ; Microtubule-Associated Proteins/metabolism ; Proteolysis ; Sequestosome-1 Protein/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Anxa2- and Ctsd-knockout CHO cell lines to diminish the risk of contamination with host cell proteins.
Autorzy :
Fukuda N; Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ibaraki, Japan.
Senga Y; Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ibaraki, Japan.
Honda S; Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Ibaraki, Japan.
Pokaż więcej
Źródło :
Biotechnology progress [Biotechnol Prog] 2019 Jul; Vol. 35 (4), pp. e2820. Date of Electronic Publication: 2019 Apr 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Annexin A2/*chemistry
Antibodies, Monoclonal/*chemistry
Cathepsin D/*chemistry
Recombinant Fusion Proteins/*chemistry
Animals ; Annexin A2/deficiency ; Annexin A2/genetics ; CHO Cells ; Cathepsin D/deficiency ; Cathepsin D/genetics ; Cell Survival ; Cells, Cultured ; Cricetulus ; Humans
Czasopismo naukowe
Tytuł :
Characterization of two types of intranuclear hepatocellular inclusions in NAFLD.
Autorzy :
Schwertheim S; Institute of Pathology, University Hospital of Essen, University of Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Germany.
Kälsch J; Institute of Pathology, University Hospital of Essen, University of Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Germany.; Department of Gastroenterology and Hepatology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany.
Jastrow H; Institute of Anatomy and Electron Microscopy Unit of Imaging Center Essen, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany.
Schaefer CM; Institute of Pathology, University Hospital of Essen, University of Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Germany.
Theurer S; Institute of Pathology, University Hospital of Essen, University of Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Germany.
Ting S; Institute of Pathology, University Hospital of Essen, University of Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Germany.
Canbay A; Department of Medicine, Ruhr University Bochum, University Hospital Knappschaftskrankenhaus Bochum, 44892, Bochum, Germany.
Wedemeyer H; Department of Gastroenterology and Hepatology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany.
Schmid KW; Institute of Pathology, University Hospital of Essen, University of Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Germany.; West German Cancer Centre Essen (WTZE), Essen, Germany.
Baba HA; Institute of Pathology, University Hospital of Essen, University of Duisburg-Essen, Hufelandstr. 55, 45147, Essen, Germany. .
Pokaż więcej
Źródło :
Scientific reports [Sci Rep] 2020 Oct 06; Vol. 10 (1), pp. 16533. Date of Electronic Publication: 2020 Oct 06.
Typ publikacji :
Journal Article
MeSH Terms :
Hepatocytes/*cytology
Intranuclear Inclusion Bodies/*metabolism
Intranuclear Inclusion Bodies/*pathology
Non-alcoholic Fatty Liver Disease/*metabolism
Non-alcoholic Fatty Liver Disease/*pathology
Adult ; Aged ; Autophagy/genetics ; Cathepsin B/metabolism ; Cathepsin D/metabolism ; Disease Progression ; Female ; Humans ; Male ; Microtubule-Associated Proteins/metabolism ; Middle Aged ; Non-alcoholic Fatty Liver Disease/genetics ; Sequestosome-1 Protein/metabolism ; Ubiquitin/metabolism ; Young Adult
Czasopismo naukowe

Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies