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Title:
Oxidation of Cathepsin D by Hydroxy Radical: Its Effect on Enzyme Structure and Activity against Myofibrillar Proteins Extracted from Coregonus peled .
Authors:
Ma M; Key Laboratory of Agricultural Product Processing and Quality Control of Specialty (Co-Construction by Ministry and Province), School of Food Science and Technology, Shihezi University, Shihezi 832003, China.; Key Laboratory of Food Nutrition and Safety Control of Xinjiang Production and Construction Crops, School of Food Science and Technology, Shihezi University, Shihezi 832003, China.
Liu P; Key Laboratory of Agricultural Product Processing and Quality Control of Specialty (Co-Construction by Ministry and Province), School of Food Science and Technology, Shihezi University, Shihezi 832003, China.; Key Laboratory of Food Nutrition and Safety Control of Xinjiang Production and Construction Crops, School of Food Science and Technology, Shihezi University, Shihezi 832003, China.
Wang C; Key Laboratory of Agricultural Product Processing and Quality Control of Specialty (Co-Construction by Ministry and Province), School of Food Science and Technology, Shihezi University, Shihezi 832003, China.; Key Laboratory of Food Nutrition and Safety Control of Xinjiang Production and Construction Crops, School of Food Science and Technology, Shihezi University, Shihezi 832003, China.
Deng X; Key Laboratory of Agricultural Product Processing and Quality Control of Specialty (Co-Construction by Ministry and Province), School of Food Science and Technology, Shihezi University, Shihezi 832003, China.; Key Laboratory of Food Nutrition and Safety Control of Xinjiang Production and Construction Crops, School of Food Science and Technology, Shihezi University, Shihezi 832003, China.
Zhang L; State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, Jiangnan University, Wuxi 214122, China.
Zhang J; Key Laboratory of Agricultural Product Processing and Quality Control of Specialty (Co-Construction by Ministry and Province), School of Food Science and Technology, Shihezi University, Shihezi 832003, China.; Key Laboratory of Food Nutrition and Safety Control of Xinjiang Production and Construction Crops, School of Food Science and Technology, Shihezi University, Shihezi 832003, China.
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Source:
Molecules (Basel, Switzerland) [Molecules] 2023 Jun 29; Vol. 28 (13). Date of Electronic Publication: 2023 Jun 29.
Publication Type:
Journal Article
MeSH Terms:
Cathepsin D*/chemistry
Hydroxyl Radical*/chemistry
Salmonidae*
Proteolysis*
Food Handling*
Oxidation-Reduction ; Animals ; Protein Conformation, beta-Strand ; Fluorescence
Academic Journal
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Title:
A Dual-Function "TRE-Lox" System for Genetic Deletion or Reversible, Titratable, and Near-Complete Downregulation of Cathepsin D.
Authors:
Terron HM; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA 92697, USA.
Maranan DS; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA 92697, USA.; Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, USA.
Burgard LA; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA 92697, USA.; Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, USA.
LaFerla FM; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA 92697, USA.; Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA 92697, USA.
Lane S; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA 92697, USA.
Leissring MA; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA 92697, USA.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2023 Apr 04; Vol. 24 (7). Date of Electronic Publication: 2023 Apr 04.
Publication Type:
Journal Article
MeSH Terms:
Cathepsin D*/genetics
Cathepsin D*/metabolism
Fibroblasts*/metabolism
Animals ; Mice ; Down-Regulation/genetics ; Tetracycline ; Doxycycline/pharmacology ; Response Elements
Academic Journal
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Title:
Prominent tauopathy and intracellular β-amyloid accumulation triggered by genetic deletion of cathepsin D: implications for Alzheimer disease pathogenesis.
Authors:
Terron HM; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine (UCI MIND), Irvine, CA, 92697, USA.
Parikh SJ; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine (UCI MIND), Irvine, CA, 92697, USA.
Abdul-Hay SO; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.
Sahara T; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.
Kang D; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.
Dickson DW; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA.
Saftig P; Institut für Biochemie, Christian-Albrechts-Universität zu Kiel, D-24098, Kiel, Germany.
LaFerla FM; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine (UCI MIND), Irvine, CA, 92697, USA.; Department of Neurobiology and Behavior, University of California, Irvine, Irvine, CA, 92697, USA.
Lane S; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine (UCI MIND), Irvine, CA, 92697, USA.
Leissring MA; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine (UCI MIND), Irvine, CA, 92697, USA. .; Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA. .
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Source:
Alzheimer's research & therapy [Alzheimers Res Ther] 2024 Apr 04; Vol. 16 (1), pp. 70. Date of Electronic Publication: 2024 Apr 04.
Publication Type:
Journal Article
MeSH Terms:
Alzheimer Disease*/pathology
Tauopathies*/genetics
Tauopathies*/metabolism
Aged ; Animals ; Humans ; Mice ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism ; Cathepsin D ; Disease Models, Animal ; Mice, Knockout ; Mice, Transgenic ; tau Proteins/genetics ; tau Proteins/metabolism
Academic Journal
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Title:
Sortilin knock-down alters the expression and distribution of cathepsin D and prosaposin and up-regulates the cation-dependent mannose-6-phosphate receptor in rat epididymal cells.
Authors:
Aguilera AC; CONICET, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, M5500, Mendoza, Argentina.; Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Cuyo, M5500, Mendoza, Argentina.
Leiva N; CONICET, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, M5500, Mendoza, Argentina.; Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Cuyo, M5500, Mendoza, Argentina.
Alvarez PA; Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Cuyo, M5500, Mendoza, Argentina.
Pulcini G; IHEM-CONICET, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, M5500, Mendoza, Argentina.
Pereyra LL; IHEM-CONICET, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, M5500, Mendoza, Argentina.
Morales CR; Faculty of Medicine, McGill University, Montreal, QC, H3A0C7, Canada.
Sosa MÁ; Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Cuyo, M5500, Mendoza, Argentina.; IHEM-CONICET, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, M5500, Mendoza, Argentina.
Carvelli L; Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Cuyo, M5500, Mendoza, Argentina. .; IHEM-CONICET, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, M5500, Mendoza, Argentina. .
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Source:
Scientific reports [Sci Rep] 2023 Mar 01; Vol. 13 (1), pp. 3461. Date of Electronic Publication: 2023 Mar 01.
Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Cathepsin D*
Epididymis*
Saposins*
Adaptor Proteins, Vesicular Transport*/genetics
Receptor, IGF Type 2*/genetics
Animals ; Male ; Rats ; Lysosomes
Academic Journal
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Title:
Impact of Enniatin B and Beauvericin on Lysosomal Cathepsin B Secretion and Apoptosis Induction.
Authors:
Aufy M; Department of Pharmaceutical Sciences, Division of Pharmacology and Toxicology, University of Vienna, 1090 Vienna, Austria.
Abdelaziz RF; Department of Pharmaceutical Sciences, Division of Pharmacology and Toxicology, University of Vienna, 1090 Vienna, Austria.
Hussein AM; Department of Pharmaceutical Sciences, Division of Pharmacology and Toxicology, University of Vienna, 1090 Vienna, Austria.; Programme for Proteomics, Paracelsus Private Medical University, 5020 Salzburg, Austria.
Topcagic N; Department of Pharmaceutical Sciences, Division of Pharmacology and Toxicology, University of Vienna, 1090 Vienna, Austria.
Shamroukh H; Department of Pharmaceutical Sciences, Division of Pharmacology and Toxicology, University of Vienna, 1090 Vienna, Austria.
Abdel-Maksoud MA; Botany and Microbiology Department, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
Salem TZ; Biomedical Sciences Program, University of Science and Technology, Zewail City of Science and Technology, Giza 12511, Egypt.
Studenik CR; Department of Pharmaceutical Sciences, Division of Pharmacology and Toxicology, University of Vienna, 1090 Vienna, Austria.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2023 Jan 19; Vol. 24 (3). Date of Electronic Publication: 2023 Jan 19.
Publication Type:
Journal Article
MeSH Terms:
Cathepsin B*/metabolism
Cathepsin D*/metabolism
Cathepsin L/metabolism ; Cell Death ; Apoptosis ; Lysosomes/metabolism
Academic Journal
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Title:
Enhanced Osteocyte Differentiation: Cathepsin D and L Secretion by Human Adipose-Derived Mesenchymal Stem Cells.
Authors:
Choi, Jung-Won (AUTHOR)
Lim, Soyeon (AUTHOR)
Jung, Seung Eun (AUTHOR)
Jeong, Seongtae (AUTHOR)
Moon, Hanbyeol (AUTHOR)
Song, Byeong-Wook (AUTHOR)
Kim, Il-Kwon (AUTHOR)
Lee, Seahyoung (AUTHOR)
Hwang, Ki-Chul (AUTHOR)
Kim, Sang Woo (AUTHOR)
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Source:
Cells (2073-4409). Dec2023, Vol. 12 Issue 24, p2852. 15p.
Academic Journal
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Title:
Restoration of Cathepsin D Level via L-Serine Attenuates PPA-Induced Lysosomal Dysfunction in Neuronal Cells.
Authors:
Jeon H; Neural Circuit Research Group, Korea Brain Research Institute, Daegu 41062, Korea.; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 42988, Korea.
Kim YJ; Neural Circuit Research Group, Korea Brain Research Institute, Daegu 41062, Korea.
Hwang SK; Department of Pediatrics, School of Medicine, Kyungpook National University, Daegu 41944, Korea.; Astrogen Inc., 440, Hyeoksin-daero, Dong-gu, Daegu 41072, Korea.
Seo J; Department of Brain Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 42988, Korea.
Mun JY; Neural Circuit Research Group, Korea Brain Research Institute, Daegu 41062, Korea.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2022 Sep 13; Vol. 23 (18). Date of Electronic Publication: 2022 Sep 13.
Publication Type:
Journal Article
MeSH Terms:
Cathepsin D*/metabolism
Neuroprotective Agents*/metabolism
Neuroprotective Agents*/pharmacology
Humans ; Lysosomes/metabolism ; Neurons/metabolism ; Propionates/pharmacology ; Serine/metabolism ; Serine/pharmacology
Academic Journal
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Title:
Expression and significance of cathepsin C and cathepsin D during pregnancy and Preeclampsia.
Authors:
Song J; Department of Obstetrics and Gynecology, Clinical Medical College, Yangzhou University, 225001, Yangzhou, Jiangsu, China.
Zhu N; Department of Obstetrics and Gynecology, Clinical Medical College, Yangzhou University, 225001, Yangzhou, Jiangsu, China. .; Graduate School of Dalian Medical University, Dalian, China. .
Pan X; Department of Obstetrics and Gynecology, Clinical Medical College, Yangzhou University, 225001, Yangzhou, Jiangsu, China.
Guo L; School of Nursing and School of Public Health, Yangzhou University, Yangzhou, China.
Kong X; Department of Obstetrics and Gynecology, Clinical Medical College, Yangzhou University, 225001, Yangzhou, Jiangsu, China. .; Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu Province, China. .; Jiangsu Key Laboratory of Experimental & Translational Non-Coding RNA Research, Yangzhou, Jiangsu Province, China. .
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Source:
Reproductive biology and endocrinology : RB&E [Reprod Biol Endocrinol] 2023 Oct 04; Vol. 21 (1), pp. 92. Date of Electronic Publication: 2023 Oct 04.
Publication Type:
Journal Article
MeSH Terms:
Pre-Eclampsia*
Female ; Humans ; Pregnancy ; Cathepsin C/metabolism ; Cathepsin D/metabolism ; Placenta/metabolism ; Pregnancy Trimester, First
Academic Journal
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Title:
Lack of Cathepsin D in the central nervous system results in microglia and astrocyte activation and the accumulation of proteinopathy-related proteins.
Authors:
Suzuki C; Department of Cellular and Molecular Neuropathology, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, 113-8421, Japan.; Department of Cellular and Molecular Pharmacology, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, 113-8421, Japan.
Yamaguchi J; Department of Cellular and Molecular Neuropathology, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, 113-8421, Japan.; Laboratory of Morphology and Image Analysis, Biomedical Research Center, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, 113-8421, Japan.
Sanada T; Department of Cellular and Molecular Neuropathology, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, 113-8421, Japan.
Oliva Trejo JA; Department of Cellular and Molecular Neuropathology, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, 113-8421, Japan.
Kakuta S; Department of Cellular and Molecular Neuropathology, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, 113-8421, Japan.; Laboratory of Morphology and Image Analysis, Biomedical Research Center, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, 113-8421, Japan.
Shibata M; Division of Morphological Sciences, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima-shi, Kagoshima, 890-8544, Japan.
Tanida I; Department of Cellular and Molecular Neuropathology, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, 113-8421, Japan. .
Uchiyama Y; Department of Cellular and Molecular Neuropathology, Juntendo University Graduate School of Medicine, Bunkyo-ku, Tokyo, 113-8421, Japan. .
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Source:
Scientific reports [Sci Rep] 2022 Jul 08; Vol. 12 (1), pp. 11662. Date of Electronic Publication: 2022 Jul 08.
Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Neuronal Ceroid-Lipofuscinoses*/pathology
Cathepsin D/*metabolism
Animals ; Astrocytes/metabolism ; Cathepsin D/genetics ; Central Nervous System/metabolism ; Disease Models, Animal ; Humans ; Mice ; Mice, Knockout ; Microglia/metabolism
Academic Journal
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Title:
The Multidirectional Effect of Azelastine Hydrochloride on Cervical Cancer Cells.
Authors:
Trybus E; Department of Medical Biology, The Jan Kochanowski University, Uniwersytecka 7, 25-406 Kielce, Poland.
Król T; Department of Medical Biology, The Jan Kochanowski University, Uniwersytecka 7, 25-406 Kielce, Poland.
Trybus W; Department of Medical Biology, The Jan Kochanowski University, Uniwersytecka 7, 25-406 Kielce, Poland.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2022 May 24; Vol. 23 (11). Date of Electronic Publication: 2022 May 24.
Publication Type:
Journal Article
MeSH Terms:
Cathepsin D*
Uterine Cervical Neoplasms*/drug therapy
Apoptosis ; Autophagy ; Caspase 3/metabolism ; Cell Line, Tumor ; Female ; HeLa Cells ; Humans ; Phthalazines ; Proto-Oncogene Proteins c-bcl-2 ; Reactive Oxygen Species/metabolism
Academic Journal
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Title:
High Expression of the Lysosomal Protease Cathepsin D Confers Better Prognosis in Neuroblastoma Patients by Contrasting EGF-Induced Neuroblastoma Cell Growth.
Authors:
Secomandi E; Laboratory of Molecular Pathology, Department of Health Sciences, Università del Piemonte Orientale 'A. Avogadro', Via Solaroli 17, 28100 Novara, Italy.
Salwa A; Laboratory of Molecular Pathology, Department of Health Sciences, Università del Piemonte Orientale 'A. Avogadro', Via Solaroli 17, 28100 Novara, Italy.
Vidoni C; Laboratory of Molecular Pathology, Department of Health Sciences, Università del Piemonte Orientale 'A. Avogadro', Via Solaroli 17, 28100 Novara, Italy.
Ferraresi A; Laboratory of Molecular Pathology, Department of Health Sciences, Università del Piemonte Orientale 'A. Avogadro', Via Solaroli 17, 28100 Novara, Italy.
Follo C; Laboratory of Molecular Pathology, Department of Health Sciences, Università del Piemonte Orientale 'A. Avogadro', Via Solaroli 17, 28100 Novara, Italy.
Isidoro C; Laboratory of Molecular Pathology, Department of Health Sciences, Università del Piemonte Orientale 'A. Avogadro', Via Solaroli 17, 28100 Novara, Italy.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2022 Apr 26; Vol. 23 (9). Date of Electronic Publication: 2022 Apr 26.
Publication Type:
Journal Article
MeSH Terms:
Cathepsin D*/genetics
Cathepsin D*/metabolism
Neuroblastoma*/metabolism
Cell Cycle/genetics ; Child ; Epidermal Growth Factor/metabolism ; ErbB Receptors/genetics ; ErbB Receptors/metabolism ; Humans ; Lysosomes/metabolism ; Peptide Hydrolases/metabolism
Academic Journal
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Title:
Increased Osteoclastogenesis in Absence of TG2 Is Reversed by Transglutaminase Inhibition-Evidence for the Role for TG1 in Osteoclast Formation.
Authors:
Ebrahimi Samani S; Faculty of Medicine and Health Sciences (Division of Experimental Medicine), McGill University, Montreal, QC H3A 0C7, Canada.
Kaartinen MT; Faculty of Medicine and Health Sciences (Division of Experimental Medicine), McGill University, Montreal, QC H3A 0C7, Canada.; Faculty of Dental Medicine and Oral Health Sciences (Biomedical Sciences), McGill University, Montreal, QC H3A 0C7, Canada.
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Source:
Cells [Cells] 2023 Aug 24; Vol. 12 (17). Date of Electronic Publication: 2023 Aug 24.
Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Osteoclasts*
Aspartic Acid Proteases*
Animals ; Mice ; Osteogenesis ; Cathepsin D ; Transglutaminases/genetics ; Aspartic Acid ; Factor XIII
Academic Journal
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Title:
Molecular characterization and functional analysis of the lysosomal cathepsin D-like gene in red swamp crayfish, Procambarus clarkii .
Authors:
Huang L; Anhui Province Key Laboratory of Aquaculture & Stock Enhancement, Fisher Institute of Anhui Academy of Agricultural Sciences, Hefei, 230031, China.; Anhui Province Key Laboratory of Aquaculture & Stock Enhancement, Fisher Institute of Anhui Academy of Agricultural Sciences, Hefei, 230031, China.
Wu BL; Anhui Province Key Laboratory of Aquaculture & Stock Enhancement, Fisher Institute of Anhui Academy of Agricultural Sciences, Hefei, 230031, China.; Anhui Province Key Laboratory of Aquaculture & Stock Enhancement, Fisher Institute of Anhui Academy of Agricultural Sciences, Hefei, 230031, China.
He JX; Anhui Province Key Laboratory of Aquaculture & Stock Enhancement, Fisher Institute of Anhui Academy of Agricultural Sciences, Hefei, 230031, China.; Anhui Province Key Laboratory of Aquaculture & Stock Enhancement, Fisher Institute of Anhui Academy of Agricultural Sciences, Hefei, 230031, China.
Zhang Y; Anhui Province Key Laboratory of Aquaculture & Stock Enhancement, Fisher Institute of Anhui Academy of Agricultural Sciences, Hefei, 230031, China.; Anhui Province Key Laboratory of Aquaculture & Stock Enhancement, Fisher Institute of Anhui Academy of Agricultural Sciences, Hefei, 230031, China.
Chen J; Anhui Province Key Laboratory of Aquaculture & Stock Enhancement, Fisher Institute of Anhui Academy of Agricultural Sciences, Hefei, 230031, China.; Anhui Province Key Laboratory of Aquaculture & Stock Enhancement, Fisher Institute of Anhui Academy of Agricultural Sciences, Hefei, 230031, China.
Chen XJ; Anhui Province Key Laboratory of Aquaculture & Stock Enhancement, Fisher Institute of Anhui Academy of Agricultural Sciences, Hefei, 230031, China.; Anhui Province Key Laboratory of Aquaculture & Stock Enhancement, Fisher Institute of Anhui Academy of Agricultural Sciences, Hefei, 230031, China.
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Source:
Genome [Genome] 2021 Dec; Vol. 64 (12), pp. 1041-1051. Date of Electronic Publication: 2021 Jul 29.
Publication Type:
Journal Article
MeSH Terms:
Arthropod Proteins*/genetics
Arthropod Proteins*/metabolism
Astacoidea*/genetics
Astacoidea*/metabolism
Cathepsin D*/genetics
Cathepsin D*/metabolism
Animals ; Gene Expression Regulation ; Immunity, Innate/genetics ; Lysosomes/metabolism ; Phylogeny
Academic Journal
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Title:
The c.863A>G (p.Glu288Gly) variant of the CTSD gene is not associated with CLN10 disease.
Authors:
Yang J; Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Ding X; Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Meng S; Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Cai J; Department of Radiology of Children's Hospital of Chongqing Medical University, Chongqing, China.
Zhou W; Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
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Source:
Molecular genetics & genomic medicine [Mol Genet Genomic Med] 2021 Oct; Vol. 9 (10), pp. e1777. Date of Electronic Publication: 2021 Jul 31.
Publication Type:
Case Reports; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Alleles*
Amino Acid Substitution*
Genetic Predisposition to Disease*
Mutation*
Cathepsin D/*genetics
Neuronal Ceroid-Lipofuscinoses/*diagnosis
Neuronal Ceroid-Lipofuscinoses/*etiology
Adolescent ; Cathepsin D/metabolism ; DNA Mutational Analysis ; Female ; Fluorescent Antibody Technique ; Gene Knockdown Techniques ; Genetic Association Studies ; Homozygote ; Humans ; Magnetic Resonance Imaging ; Phenotype ; Protein Transport ; Exome Sequencing
Academic Journal
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Title:
The lysosomal endopeptidases Cathepsin D and L are selective and effective proteases for the middle-down characterization of antibodies.
Authors:
Čaval T; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, The Netherlands.; Netherlands Proteomics Centre, Utrecht, The Netherlands.
Hecht ES; Department of Microchemistry, Proteomics, and Lipidomics & Next Generation Sequencing, Genentech, Inc., South San Francisco, CA, USA.
Tang W; Protein Metrics Inc., San Carlos, CA, USA.
Uy-Gomez M; Department of Microchemistry, Proteomics, and Lipidomics & Next Generation Sequencing, Genentech, Inc., South San Francisco, CA, USA.
Nichols A; Protein Metrics Inc., San Carlos, CA, USA.
Kil YJ; Protein Metrics Inc., San Carlos, CA, USA.
Sandoval W; Department of Microchemistry, Proteomics, and Lipidomics & Next Generation Sequencing, Genentech, Inc., South San Francisco, CA, USA.
Bern M; Protein Metrics Inc., San Carlos, CA, USA.
Heck AJR; Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, The Netherlands.; Netherlands Proteomics Centre, Utrecht, The Netherlands.
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Source:
The FEBS journal [FEBS J] 2021 Sep; Vol. 288 (18), pp. 5389-5405. Date of Electronic Publication: 2021 Mar 27.
Publication Type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms:
Cathepsin D/*genetics
Cathepsin L/*genetics
Endopeptidases/*genetics
Lysosomes/*genetics
Amino Acid Sequence/genetics ; Antibodies/genetics ; Antibodies/immunology ; Cathepsin D/immunology ; Cathepsin L/immunology ; Endopeptidases/immunology ; Humans ; Immunoglobulin G/genetics ; Immunoglobulin G/immunology ; Lysosomes/enzymology ; Mass Spectrometry ; Peptide Hydrolases/genetics ; Proteolysis
Academic Journal
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Title:
Proteolytic Resistance Determines Albumin Nanoparticle Drug Delivery Properties and Increases Cathepsin B, D, and G Expression.
Authors:
Kolesova EP; Scientific Center for Translation Medicine, Sirius University of Science and Technology, 354340 Sochi, Russia.
Egorova VS; Scientific Center for Translation Medicine, Sirius University of Science and Technology, 354340 Sochi, Russia.
Syrocheva AO; Scientific Center for Translation Medicine, Sirius University of Science and Technology, 354340 Sochi, Russia.
Frolova AS; Scientific Center for Translation Medicine, Sirius University of Science and Technology, 354340 Sochi, Russia.; Institute of Molecular Medicine, Sechenov First Moscow State Medical University, 119991 Moscow, Russia.
Kostyushev D; Scientific Center for Translation Medicine, Sirius University of Science and Technology, 354340 Sochi, Russia.; Martsinovsky Institute of Medical Parasitology, Tropical and Vector-Borne Diseases, Sechenov First Moscow State Medical University, 119991 Moscow, Russia.
Kostyusheva A; Scientific Center for Translation Medicine, Sirius University of Science and Technology, 354340 Sochi, Russia.; Martsinovsky Institute of Medical Parasitology, Tropical and Vector-Borne Diseases, Sechenov First Moscow State Medical University, 119991 Moscow, Russia.
Brezgin S; Scientific Center for Translation Medicine, Sirius University of Science and Technology, 354340 Sochi, Russia.; Martsinovsky Institute of Medical Parasitology, Tropical and Vector-Borne Diseases, Sechenov First Moscow State Medical University, 119991 Moscow, Russia.
Trushina DB; Department of Biomedical Engineering, Sechenov First Moscow State Medical University, 119991 Moscow, Russia.; Federal Scientific Research Center 'Crystallography and Photonics', Russian Academy of Sciences, 119333 Moscow, Russia.
Fatkhutdinova L; School of Physics, ITMO University, Lomonosova 9, 191002 St. Petersburg, Russia.
Zyuzin M; School of Physics, ITMO University, Lomonosova 9, 191002 St. Petersburg, Russia.
Demina PA; Federal Scientific Research Center 'Crystallography and Photonics', Russian Academy of Sciences, 119333 Moscow, Russia.; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
Khaydukov EV; Scientific Center for Translation Medicine, Sirius University of Science and Technology, 354340 Sochi, Russia.; Federal Scientific Research Center 'Crystallography and Photonics', Russian Academy of Sciences, 119333 Moscow, Russia.; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
Zamyatnin AA Jr; Scientific Center for Translation Medicine, Sirius University of Science and Technology, 354340 Sochi, Russia.; Institute of Molecular Medicine, Sechenov First Moscow State Medical University, 119991 Moscow, Russia.; Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia.; Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7X, UK.
Parodi A; Scientific Center for Translation Medicine, Sirius University of Science and Technology, 354340 Sochi, Russia.; Institute of Molecular Medicine, Sechenov First Moscow State Medical University, 119991 Moscow, Russia.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2023 Jun 16; Vol. 24 (12). Date of Electronic Publication: 2023 Jun 16.
Publication Type:
Journal Article
MeSH Terms:
Neoplasms*/metabolism
Nanoparticles*
Humans ; Cathepsin B/metabolism ; Proteolysis ; Peptide Hydrolases/metabolism ; Albumins/metabolism ; Lysosomes/metabolism ; Cathepsin D/metabolism
Academic Journal
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Title:
Cathepsin B and D deficiency in the mouse pancreas induces impaired autophagy and chronic pancreatitis.
Authors:
Iwama H; Department of Genetics, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan.; Department of Gastroenterological Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo, 663-8501, Japan.
Mehanna S; Institute of Resource Development and Analysis, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto, 860-0811, Japan.; Department of Veterinary Hygiene and Management, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt.
Imasaka M; Department of Genetics, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan.
Hashidume S; Department of Genetics, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan.
Nishiura H; Division of Functional Pathology, Department of Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo, 663-8501, Japan.
Yamamura KI; Institute of Resource Development and Analysis, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto, 860-0811, Japan.
Suzuki C; Department of Pharmacology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Uchiyama Y; Department of Cell Biology and Neuroscience, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Hatano E; Department of Gastroenterological Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo, 663-8501, Japan.
Ohmuraya M; Department of Genetics, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan. .
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Source:
Scientific reports [Sci Rep] 2021 Mar 23; Vol. 11 (1), pp. 6596. Date of Electronic Publication: 2021 Mar 23.
Publication Type:
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:
Autophagy*
Cathepsin B/*deficiency
Cathepsin D/*deficiency
Pancreas/*metabolism
Pancreatitis, Chronic/*metabolism
Acinar Cells/metabolism ; Animals ; Autophagosomes/metabolism ; Cathepsin B/genetics ; Cathepsin B/metabolism ; Cathepsin D/genetics ; Cathepsin D/metabolism ; Mice ; Pancreas/cytology ; Pancreatitis, Chronic/genetics
Academic Journal
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Title:
Identification of Novel Genomic-Variant Patterns of OR56A5, OR52L1, and CTSD in Retinitis Pigmentosa Patients by Whole-Exome Sequencing.
Authors:
Lin TY; College of Medicine, Kaohsiung Medical University, Kaohsiung 807378, Taiwan.
Chang YC; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei 112304, Taiwan.
Hsiao YJ; College of Medicine, National Yang-Ming Chiao-Tung University, Taipei 11217, Taiwan.
Chien Y; Department of Medical Research, Taipei Veterans General Hospital, Taipei 11217, Taiwan.; Institute of Pharmacology, National Yang-Ming Chiao Tung University, Taipei 112304, Taiwan.
Jheng YC; Department of Medical Research, Taipei Veterans General Hospital, Taipei 11217, Taiwan.; School of Medicine, National Yang-Ming Chiao Tung University, Taipei 112304, Taiwan.; Big Data Center, Taipei Veterans General Hospital, Taipei 112201, Taiwan.
Wu JR; Department of Medical Research, Taipei Veterans General Hospital, Taipei 11217, Taiwan.
Ching LJ; Department of Medical Research, Taipei Veterans General Hospital, Taipei 11217, Taiwan.
Hwang DK; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei 112304, Taiwan.; Department of Medical Research, Taipei Veterans General Hospital, Taipei 11217, Taiwan.; School of Medicine, National Yang-Ming Chiao Tung University, Taipei 112304, Taiwan.; Institute of Clinical Medicine, National Yang-Ming Chiao Tung University, Taipei 112304, Taiwan.
Hsu CC; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei 112304, Taiwan.
Lin TC; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei 112304, Taiwan.; Department of Medical Research, Taipei Veterans General Hospital, Taipei 11217, Taiwan.; School of Medicine, National Yang-Ming Chiao Tung University, Taipei 112304, Taiwan.; Institute of Clinical Medicine, National Yang-Ming Chiao Tung University, Taipei 112304, Taiwan.
Chou YB; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei 112304, Taiwan.
Huang YM; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei 112304, Taiwan.
Chen SJ; Department of Ophthalmology, Taipei Veterans General Hospital, Taipei 112304, Taiwan.; School of Medicine, National Yang-Ming Chiao Tung University, Taipei 112304, Taiwan.
Yang YP; Department of Medical Research, Taipei Veterans General Hospital, Taipei 11217, Taiwan.; School of Medicine, National Yang-Ming Chiao Tung University, Taipei 112304, Taiwan.; Department of Internal Medicine, Taipei Veterans General Hospital, Taipei 112201, Taiwan.; Critical Center, Taipei Veterans General Hospital, Taipei 112201, Taiwan.
Tsai PH; Department of Medical Research, Taipei Veterans General Hospital, Taipei 11217, Taiwan.; Institute of Pharmacology, National Yang-Ming Chiao Tung University, Taipei 112304, Taiwan.
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Source:
International journal of molecular sciences [Int J Mol Sci] 2021 May 25; Vol. 22 (11). Date of Electronic Publication: 2021 May 25.
Publication Type:
Case Reports; Journal Article
MeSH Terms:
Genetic Predisposition to Disease*
Cathepsin D/*genetics
Retinal Dystrophies/*genetics
Adult ; Aged ; Cathepsin D/blood ; Female ; Frameshift Mutation ; Gene Ontology ; Humans ; Male ; Middle Aged ; Muscle Proteins/genetics ; Mutation, Missense ; Pedigree ; Perforin/genetics ; Plasma Membrane Calcium-Transporting ATPases/genetics ; Polymorphism, Single Nucleotide ; Protein Interaction Maps ; Retinal Dystrophies/congenital ; Retinal Dystrophies/pathology ; Retinitis Pigmentosa/congenital ; Retinitis Pigmentosa/diagnostic imaging ; Retinitis Pigmentosa/genetics ; Retinitis Pigmentosa/pathology ; Risk Factors ; Tomography, Optical Coherence ; Exome Sequencing
Academic Journal
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