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Wyszukujesz frazę ""Cell Cycle"" wg kryterium: Temat


Tytuł :
Nickel carcinogenesis mechanism: cell cycle dysregulation.
Autorzy :
Guo H; College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu, 611130, China.; Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agriculture University, Wenjiang, Chengdu, 611130, China.
Deng H; College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu, 611130, China. .; Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agriculture University, Wenjiang, Chengdu, 611130, China. .
Liu H; College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu, 611130, China.
Jian Z; College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu, 611130, China.
Cui H; College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu, 611130, China. .; Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agriculture University, Wenjiang, Chengdu, 611130, China. .; Key Laboratory of Agricultural information engineering of Sichuan Province, Sichuan Agriculture University, Yaan, Sichuan, 625014, China. .
Fang J; College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu, 611130, China.; Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agriculture University, Wenjiang, Chengdu, 611130, China.
Zuo Z; College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu, 611130, China.; Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agriculture University, Wenjiang, Chengdu, 611130, China.
Deng J; College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu, 611130, China.; Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agriculture University, Wenjiang, Chengdu, 611130, China.
Li Y; College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu, 611130, China.; Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agriculture University, Wenjiang, Chengdu, 611130, China.
Wang X; College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu, 611130, China.; Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agriculture University, Wenjiang, Chengdu, 611130, China.
Zhao L; College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu, 611130, China.; Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agriculture University, Wenjiang, Chengdu, 611130, China.
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Źródło :
Environmental science and pollution research international [Environ Sci Pollut Res Int] 2021 Feb; Vol. 28 (5), pp. 4893-4901. Date of Electronic Publication: 2020 Nov 23.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Cell Cycle Proteins*/genetics
Cell Cycle Proteins*/metabolism
Nickel*/toxicity
Animals ; Ataxia Telangiectasia Mutated Proteins ; Carcinogenesis ; Cell Cycle ; Cell Division ; Humans ; Signal Transduction ; Tumor Suppressor Protein p53/metabolism
Czasopismo naukowe
Tytuł :
CDC20 assists its catalytic incorporation in the mitotic checkpoint complex.
Autorzy :
Piano V; Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, 44227 Dortmund, Germany. .
Alex A; Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, 44227 Dortmund, Germany.
Stege P; Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, 44227 Dortmund, Germany.
Maffini S; Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, 44227 Dortmund, Germany.
Stoppiello GA; Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, 44227 Dortmund, Germany.
Huis In 't Veld PJ; Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, 44227 Dortmund, Germany.
Vetter IR; Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, 44227 Dortmund, Germany.
Musacchio A; Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, 44227 Dortmund, Germany. .; Centre for Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, 45141 Essen, Germany.
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Źródło :
Science (New York, N.Y.) [Science] 2021 Jan 01; Vol. 371 (6524), pp. 67-71.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
M Phase Cell Cycle Checkpoints*
Cdc20 Proteins/*metabolism
Kinetochores/*metabolism
Mad2 Proteins/*metabolism
Multiprotein Complexes/*metabolism
Biocatalysis ; Cell Cycle Proteins/metabolism ; HeLa Cells ; Humans ; Mad2 Proteins/genetics ; Mutation ; Poly-ADP-Ribose Binding Proteins/metabolism ; Protein-Serine-Threonine Kinases ; Spindle Apparatus/metabolism
Czasopismo naukowe
Tytuł :
Interphase-arrested Drosophila embryos activate zygotic gene expression and initiate mid-blastula transition events at a low nuclear-cytoplasmic ratio.
Autorzy :
Strong IJT; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America.
Lei X; Hunan Key Laboratory of Molecular Precision Medicine, Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Chen F; Hunan Key Laboratory of Molecular Precision Medicine, Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yuan K; Hunan Key Laboratory of Molecular Precision Medicine, Department of Oncology, Xiangya Hospital, Central South University, Changsha, Hunan, China.; Hunan Key Laboratory of Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.
O'Farrell PH; Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America.
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Źródło :
PLoS biology [PLoS Biol] 2020 Oct 22; Vol. 18 (10), pp. e3000891. Date of Electronic Publication: 2020 Oct 22 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Cell Cycle Checkpoints*/genetics
Gene Expression Regulation, Developmental*
Interphase*/genetics
Blastula/*cytology
Cell Nucleus/*metabolism
Drosophila melanogaster/*embryology
Embryo, Nonmammalian/*cytology
Zygote/*metabolism
Animals ; Cell Cycle Proteins/metabolism ; Drosophila melanogaster/cytology ; Drosophila melanogaster/genetics ; Gastrulation ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Transcription, Genetic ; Transcriptome/genetics
Czasopismo naukowe
Tytuł :
CHK1 monitors spindle assembly checkpoint and DNA damage repair during the first cleavage of mouse early embryos.
Autorzy :
Ju JQ; College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China.
Li XH; College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China.
Pan MH; College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China.
Xu Y; College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China.
Sun MH; College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China.
Xu Y; College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China.
Sun SC; College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China.
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Źródło :
Cell proliferation [Cell Prolif] 2020 Oct; Vol. 53 (10), pp. e12895. Date of Electronic Publication: 2020 Sep 10.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Repair*
M Phase Cell Cycle Checkpoints*/drug effects
Checkpoint Kinase 1/*metabolism
Animals ; Apoptosis/drug effects ; Aurora Kinase B/metabolism ; Cell Cycle Proteins/metabolism ; Checkpoint Kinase 1/antagonists & inhibitors ; Chromosome Segregation/drug effects ; DNA Damage/drug effects ; Embryo, Mammalian/cytology ; Embryo, Mammalian/metabolism ; Embryonic Development/drug effects ; Kinetochores/metabolism ; Mice ; Microtubules/metabolism ; Oxidative Stress/drug effects ; Phenylurea Compounds/pharmacology ; Protein-Serine-Threonine Kinases/metabolism ; Pyrazines/pharmacology ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
Cell Cycle Regulation in Macrophages and Susceptibility to HIV-1.
Autorzy :
Ferreira IATM; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge CB20AW, UK.; Department of Medicine, University of Cambridge, Cambridge CB20QQ, UK.
Porterfield JZ; Department of Microbiology, University of Kentucky, Lexington, KY 40536, USA.; Africa Health Research Institute, Durban 4001, South Africa.
Gupta RK; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge CB20AW, UK.; Department of Medicine, University of Cambridge, Cambridge CB20QQ, UK.; Africa Health Research Institute, Durban 4001, South Africa.
Mlcochova P; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Cambridge CB20AW, UK.; Department of Medicine, University of Cambridge, Cambridge CB20QQ, UK.
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Źródło :
Viruses [Viruses] 2020 Jul 31; Vol. 12 (8). Date of Electronic Publication: 2020 Jul 31.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Cell Cycle*
HIV-1/*physiology
Macrophages/*physiology
Macrophages/*virology
Animals ; Cell Cycle Checkpoints ; Cells, Cultured ; DNA Damage ; G1 Phase ; Gram-Negative Bacteria/immunology ; Histone Deacetylase Inhibitors/pharmacology ; Humans ; Macrophages/immunology ; Phosphorylation ; Resting Phase, Cell Cycle ; SAM Domain and HD Domain-Containing Protein 1/metabolism ; vif Gene Products, Human Immunodeficiency Virus/metabolism ; vpr Gene Products, Human Immunodeficiency Virus/metabolism
Czasopismo naukowe
Tytuł :
Chromatin structure restricts origin utilization when quiescent cells re-enter the cell cycle.
Autorzy :
Lee PH; Department of Molecular Genetics and Microbiology University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
Osley MA; Department of Molecular Genetics and Microbiology University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Jan 25; Vol. 49 (2), pp. 864-878.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cell Cycle/*physiology
Chromatin/*ultrastructure
Replication Origin/*genetics
Saccharomyces cerevisiae/*genetics
Cell Cycle/genetics ; Cell Cycle Checkpoints ; Chromatin/genetics ; Chromatin Assembly and Disassembly ; Chromatin Immunoprecipitation ; DNA Replication ; DNA, Fungal/biosynthesis ; DNA, Fungal/genetics ; Minichromosome Maintenance Complex Component 4/metabolism ; Nucleosomes/metabolism ; Nucleosomes/ultrastructure ; Saccharomyces cerevisiae/ultrastructure ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism
Czasopismo naukowe
Tytuł :
A tripartite mechanism catalyzes Mad2-Cdc20 assembly at unattached kinetochores.
Autorzy :
Lara-Gonzalez P; Section of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA, USA. .; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.; Ludwig Institute for Cancer Research, San Diego Branch, 9500 Gilman Drive, La Jolla, CA, USA.
Kim T; Section of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.; Ludwig Institute for Cancer Research, San Diego Branch, 9500 Gilman Drive, La Jolla, CA, USA.
Oegema K; Section of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA, USA.; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.; Ludwig Institute for Cancer Research, San Diego Branch, 9500 Gilman Drive, La Jolla, CA, USA.
Corbett K; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.; Ludwig Institute for Cancer Research, San Diego Branch, 9500 Gilman Drive, La Jolla, CA, USA.
Desai A; Section of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, La Jolla, CA, USA. .; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.; Ludwig Institute for Cancer Research, San Diego Branch, 9500 Gilman Drive, La Jolla, CA, USA.
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Źródło :
Science (New York, N.Y.) [Science] 2021 Jan 01; Vol. 371 (6524), pp. 64-67.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Cycle Checkpoints*
Caenorhabditis elegans/*metabolism
Caenorhabditis elegans Proteins/*metabolism
Cdc20 Proteins/*metabolism
Cell Cycle Proteins/*metabolism
Kinetochores/*metabolism
Animals ; Biocatalysis ; Caenorhabditis elegans/cytology ; Caenorhabditis elegans/genetics ; Caenorhabditis elegans Proteins/genetics ; Mitosis ; Protein-Serine-Threonine Kinases/genetics ; Protein-Serine-Threonine Kinases/metabolism
Czasopismo naukowe
Tytuł :
High Wilms' tumor 1 associating protein expression predicts poor prognosis in acute myeloid leukemia and regulates m A methylation of MYC mRNA.
Autorzy :
Naren D; Department of Hematology, Hematology Research Laboratory, West China Hospital, Sichuan University, 37# GuoXue Xiang, Chengdu, 610041, Sichuan Province, China.
Yan T; Department of Hematology, Hematology Research Laboratory, West China Hospital, Sichuan University, 37# GuoXue Xiang, Chengdu, 610041, Sichuan Province, China.
Gong Y; Department of Hematology, Hematology Research Laboratory, West China Hospital, Sichuan University, 37# GuoXue Xiang, Chengdu, 610041, Sichuan Province, China. .
Huang J; Department of Hematology, Hematology Research Laboratory, West China Hospital, Sichuan University, 37# GuoXue Xiang, Chengdu, 610041, Sichuan Province, China.
Zhang D; Department of Hematology, Hematology Research Laboratory, West China Hospital, Sichuan University, 37# GuoXue Xiang, Chengdu, 610041, Sichuan Province, China.
Sang L; Department of Hematology, Hematology Research Laboratory, West China Hospital, Sichuan University, 37# GuoXue Xiang, Chengdu, 610041, Sichuan Province, China.
Zheng X; Department of Hematology, Hematology Research Laboratory, West China Hospital, Sichuan University, 37# GuoXue Xiang, Chengdu, 610041, Sichuan Province, China.
Li Y; Department of Hematology, Hematology Research Laboratory, West China Hospital, Sichuan University, 37# GuoXue Xiang, Chengdu, 610041, Sichuan Province, China.
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Źródło :
Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2021 Jan; Vol. 147 (1), pp. 33-47. Date of Electronic Publication: 2020 Sep 03.
Typ publikacji :
Journal Article
MeSH Terms :
DNA Methylation*
Gene Expression Regulation, Neoplastic*
Adenosine/*analogs & derivatives
Cell Cycle Proteins/*metabolism
Leukemia, Myeloid, Acute/*pathology
Proto-Oncogene Proteins c-myc/*genetics
RNA Splicing Factors/*metabolism
RNA, Messenger/*genetics
Adenosine/chemistry ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Apoptosis ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Case-Control Studies ; Cell Cycle ; Cell Cycle Proteins/genetics ; Cell Differentiation ; Cell Proliferation ; Female ; Follow-Up Studies ; Humans ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/metabolism ; Male ; Middle Aged ; Prognosis ; Proto-Oncogene Proteins c-myc/chemistry ; Proto-Oncogene Proteins c-myc/metabolism ; RNA Splicing Factors/genetics ; RNA, Messenger/metabolism ; Survival Rate ; Tumor Cells, Cultured ; Young Adult
Czasopismo naukowe
Tytuł :
Protein phosphatase 1 regulatory subunit 35 is required for ciliogenesis, notochord morphogenesis, and cell-cycle progression during murine development.
Autorzy :
Archambault D; Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA, USA.
Cheong A; Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA, USA.
Iverson E; Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA, USA.
Tremblay KD; Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA, USA. Electronic address: .
Mager J; Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA, USA. Electronic address: .
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Źródło :
Developmental biology [Dev Biol] 2020 Sep 01; Vol. 465 (1), pp. 1-10. Date of Electronic Publication: 2020 Jul 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cell Cycle*
Organogenesis*
Cell Cycle Proteins/*metabolism
Cilia/*metabolism
Notochord/*enzymology
Animals ; Cell Cycle Proteins/genetics ; Cilia/genetics ; Mice ; Mice, Knockout
Czasopismo naukowe
Tytuł :
Divergence of the PIERCE1 expression between mice and humans as a p53 target gene.
Autorzy :
Kim HJ; Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea.
Lee SE; Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea.
Na H; Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea.
Roe JS; Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea.
Roh JI; Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea.
Lee HW; Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea.
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Źródło :
PloS one [PLoS One] 2020 Aug 03; Vol. 15 (8), pp. e0236881. Date of Electronic Publication: 2020 Aug 03 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Cycle Proteins*/genetics
Cell Cycle Proteins*/metabolism
Response Elements/*genetics
Tumor Suppressor Protein p53/*metabolism
Animals ; Cell Cycle/genetics ; Cell Line, Tumor ; DNA Damage/genetics ; Humans ; Mice ; Promoter Regions, Genetic ; Transcription, Genetic/physiology
Czasopismo naukowe
Tytuł :
AMG900 as novel inhibitor of the translationally controlled tumor protein.
Autorzy :
Fischer N; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128, Mainz, Germany.
Seo EJ; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128, Mainz, Germany.
Klinger A; MicroCombiChem GmbH, Wiesbaden, Germany.
Fleischer E; MicroCombiChem GmbH, Wiesbaden, Germany.
Efferth T; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, 55128, Mainz, Germany. Electronic address: .
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Źródło :
Chemico-biological interactions [Chem Biol Interact] 2021 Jan 25; Vol. 334, pp. 109349. Date of Electronic Publication: 2020 Nov 28.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Cycle Proteins/*metabolism
Neoplasms/*drug therapy
Neoplasms/*metabolism
Phthalazines/*pharmacology
Protein Biosynthesis/*drug effects
Apoptosis/drug effects ; Biomarkers, Tumor/metabolism ; Cell Line, Tumor ; G1 Phase/drug effects ; Humans ; MCF-7 Cells ; Molecular Docking Simulation ; Resting Phase, Cell Cycle/drug effects
Czasopismo naukowe
Tytuł :
Transmembrane and Immunoglobulin Domain Containing 1, a Putative Tumor Suppressor, Induces G2/M Cell Cycle Checkpoint Arrest in Colon Cancer Cells.
Autorzy :
De La Cena KOC; Department of Pathology, School of Medicine, Boston University Medical Campus, Boston, Massachusetts.
Ho RX; Department of Pathology, School of Medicine, Boston University Medical Campus, Boston, Massachusetts.
Amraei R; Department of Pathology, School of Medicine, Boston University Medical Campus, Boston, Massachusetts.
Woolf N; Department of Pathology, School of Medicine, Boston University Medical Campus, Boston, Massachusetts.
Tashjian JY; Department of Pathology, School of Medicine, Boston University Medical Campus, Boston, Massachusetts.
Zhao Q; Department of Pathology, School of Medicine, Boston University Medical Campus, Boston, Massachusetts.
Richards S; Renal Section, Department of Medicine, Boston Medical Center, Boston, Massachusetts.
Walker J; Renal Section, Department of Medicine, Boston Medical Center, Boston, Massachusetts.
Huang J; Department of Pathology, School of Medicine, Boston University Medical Campus, Boston, Massachusetts.
Chitalia VC; Renal Section, Department of Medicine, Boston Medical Center, Boston, Massachusetts; Boston Veterans Affairs Healthcare System, Boston, Massachusetts.
Rahimi N; Department of Pathology, School of Medicine, Boston University Medical Campus, Boston, Massachusetts. Electronic address: .
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Źródło :
The American journal of pathology [Am J Pathol] 2021 Jan; Vol. 191 (1), pp. 157-167. Date of Electronic Publication: 2020 Oct 29.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cell Cycle Checkpoints/*physiology
Colonic Neoplasms/*metabolism
Membrane Glycoproteins/*metabolism
Adenoma/genetics ; Adenoma/metabolism ; Adenoma/pathology ; Animals ; Cell Movement/genetics ; Cell Proliferation/genetics ; Cell Transformation, Neoplastic/metabolism ; Colonic Neoplasms/genetics ; Colonic Neoplasms/pathology ; G2 Phase Cell Cycle Checkpoints/physiology ; Genes, Tumor Suppressor/physiology ; Humans ; Membrane Glycoproteins/genetics ; Mice ; Mice, Knockout ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism
Czasopismo naukowe
Tytuł :
Antitumor Effects of the Novel Quinazolinone Holu-12: Induction of Mitotic Arrest and Apoptosis in Human Oral Squamous Cell Carcinoma CAL27 Cells.
Autorzy :
Lai KC; Department of Physiology and Pharmacology, College of Medicine, Chang Gung University, Taoyuan, Taiwan, R.O.C.
Chia YT; Master's program in Pharmacology and Toxicology, College of Medicine, Tzu Chi University, Hualien, Taiwan, R.O.C.
Yih LH; Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan, R.O.C.
Lu YL; School of Pharmacy, China Medical University, Taichung, Taiwan, R.O.C.
Chang ST; School of Pharmacy, China Medical University, Taichung, Taiwan, R.O.C.
Hong ZX; Master's program in Pharmacology and Toxicology, College of Medicine, Tzu Chi University, Hualien, Taiwan, R.O.C.
Chen TL; School of Pharmacy, China Medical University, Taichung, Taiwan, R.O.C.
Hour MJ; School of Pharmacy, China Medical University, Taichung, Taiwan, R.O.C. .
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Źródło :
Anticancer research [Anticancer Res] 2021 Jan; Vol. 41 (1), pp. 259-268.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Apoptosis/*drug effects
Cell Cycle Checkpoints/*drug effects
Quinazolinones/*pharmacology
Animals ; Antineoplastic Agents/chemistry ; Carcinoma, Squamous Cell ; Cell Cycle/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drug Resistance, Neoplasm/drug effects ; Flow Cytometry ; Fluorouracil/pharmacology ; Humans ; Mice ; Mitosis/drug effects ; Mouth Neoplasms ; Quinazolinones/chemistry ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Leukemia inhibitory factor promotes gastric cancer cell proliferation, migration, and invasion via the LIFR-Hippo-YAP pathway.
Autorzy :
Bian SB; Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Cancer Invasion and Metastasis Research & National Clinical Research Center for Digestive Diseases, Beijing, China.; Department of General Surgery, Chinese People's Liberation Army General Hospital, Beijing, China.
Yang Y; Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Cancer Invasion and Metastasis Research & National Clinical Research Center for Digestive Diseases, Beijing, China.
Liang WQ; Department of General Surgery, Chinese People's Liberation Army General Hospital, Beijing, China.
Zhang KC; Department of General Surgery, Chinese People's Liberation Army General Hospital, Beijing, China.
Chen L; Department of General Surgery, Chinese People's Liberation Army General Hospital, Beijing, China.
Zhang ZT; Department of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing Key Laboratory of Cancer Invasion and Metastasis Research & National Clinical Research Center for Digestive Diseases, Beijing, China.
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Źródło :
Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2021 Jan; Vol. 1484 (1), pp. 74-89. Date of Electronic Publication: 2020 Aug 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Cycle Proteins/*genetics
Leukemia Inhibitory Factor/*genetics
Leukemia Inhibitory Factor Receptor alpha Subunit/*genetics
Stomach Neoplasms/*genetics
Transcription Factors/*genetics
Aged ; Apoptosis/genetics ; Biomarkers, Tumor/genetics ; Cell Cycle/genetics ; Cell Movement/genetics ; Cell Proliferation/genetics ; Female ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Male ; Middle Aged ; Neoplasm Invasiveness/genetics ; Neoplasm Invasiveness/pathology ; Protein-Serine-Threonine Kinases/genetics ; RNA, Messenger/genetics ; Signal Transduction/genetics ; Stomach Neoplasms/pathology
Czasopismo naukowe
Tytuł :
Downregulation of nuclear protein-1 induces cell cycle arrest in G0/G1 phase in glioma cells in vivo and in vitro via P27.
Autorzy :
Li J; Department of Neurosurgery, First Affiliated Hospital of Dalian Medical University, Dalian Medical University, Dalian, China.
Lian ZG; Department of Neurosurgery, First Affiliated Hospital of Dalian Medical University, Dalian Medical University, Dalian, China.
Xu YH; Department of Neurosurgery, First Affiliated Hospital of Dalian Medical University, Dalian Medical University, Dalian, China.
Liu RY; Department of Neurosurgery, First Affiliated Hospital of Dalian Medical University, Dalian Medical University, Dalian, China.
Wei ZQ; Department of Neurosurgery, First Affiliated Hospital of Dalian Medical University, Dalian Medical University, Dalian, China.
Li T; Department of Neurosurgery, First Affiliated Hospital of Dalian Medical University, Dalian Medical University, Dalian, China.
Lv HT; Department of Neurosurgery, First Affiliated Hospital of Dalian Medical University, Dalian Medical University, Dalian, China.
Zhao YS; Department of Neurosurgery, First Affiliated Hospital of Dalian Medical University, Dalian Medical University, Dalian, China.
Liu YJ; Department of Interventional Therapy, First Affiliated Hospital of Dalian Medical University, Dalian Medical University, Dalian, China.
Dong B; Department of Neurosurgery, First Affiliated Hospital of Dalian Medical University, Dalian Medical University, Dalian, China.
Fu X; Department of Neurosurgery, First Affiliated Hospital of Dalian Medical University, Dalian Medical University, Dalian, China.
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Źródło :
Neoplasma [Neoplasma] 2020 Jul; Vol. 67 (4), pp. 843-850. Date of Electronic Publication: 2020 Apr 07.
Typ publikacji :
Journal Article
MeSH Terms :
Basic Helix-Loop-Helix Transcription Factors*/physiology
Brain Neoplasms*/genetics
Brain Neoplasms*/pathology
Cell Cycle*
Glioma*/genetics
Glioma*/pathology
Neoplasm Proteins*/physiology
Nuclear Proteins*
Animals ; Cell Cycle Checkpoints ; Cell Line, Tumor ; Cell Proliferation ; Down-Regulation ; G1 Phase ; Humans ; Mice ; Mice, Nude ; Proliferating Cell Nuclear Antigen
Czasopismo naukowe
Tytuł :
Unifying the mechanism of mitotic exit control in a spatiotemporal logical model.
Autorzy :
Howell RSM; The Francis Crick Institute, London, United Kingdom.; Randall Centre for Cell and Molecular Biophysics, King's College London, London, United Kingdom.
Klemm C; School of Biological and Chemical Sciences, Queen Mary University, London, United Kingdom.
Thorpe PH; School of Biological and Chemical Sciences, Queen Mary University, London, United Kingdom.
Csikász-Nagy A; Randall Centre for Cell and Molecular Biophysics, King's College London, London, United Kingdom.; Faculty of Information Technology and Bionics, Pázmány Péter Catholic University, Budapest, Hungary.
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Źródło :
PLoS biology [PLoS Biol] 2020 Nov 12; Vol. 18 (11), pp. e3000917. Date of Electronic Publication: 2020 Nov 12 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Cycle/*genetics
M Phase Cell Cycle Checkpoints/*physiology
Cell Cycle/physiology ; Cell Cycle Proteins/metabolism ; Cell Cycle Proteins/physiology ; Cell Nucleus Division/physiology ; M Phase Cell Cycle Checkpoints/genetics ; Mitosis/physiology ; Phosphorylation ; Protein Tyrosine Phosphatases/genetics ; Protein Tyrosine Phosphatases/metabolism ; Protein Tyrosine Phosphatases/physiology ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/metabolism ; Saccharomyces cerevisiae Proteins/physiology ; Saccharomycetales/genetics ; Saccharomycetales/metabolism ; Spindle Apparatus/physiology
Czasopismo naukowe
Tytuł :
Effect of PIERCE1 on colorectal cancer.
Autorzy :
Park BM; Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Yonsei Ro 50, Seodaemun-gu, Seoul 03722, Republic of Korea.
Kim HJ; Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Yonsei Ro 50, Seodaemun-gu, Seoul 03722, Republic of Korea.
Oh JH; Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Yonsei Ro 50, Seodaemun-gu, Seoul 03722, Republic of Korea.
Roh JI; Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Yonsei Ro 50, Seodaemun-gu, Seoul 03722, Republic of Korea.
Lee HW; Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Yonsei Ro 50, Seodaemun-gu, Seoul 03722, Republic of Korea.
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Źródło :
Experimental animals [Exp Anim] 2020 Nov 12; Vol. 69 (4), pp. 414-422. Date of Electronic Publication: 2020 Jun 25.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression*
Cell Cycle Proteins/*genetics
Cell Cycle Proteins/*metabolism
Colorectal Neoplasms/*genetics
Animals ; Azoxymethane/adverse effects ; Cell Cycle/genetics ; Cell Cycle Proteins/physiology ; Cell Line, Tumor ; Cell Proliferation/genetics ; Colorectal Neoplasms/chemically induced ; Colorectal Neoplasms/pathology ; Dextran Sulfate/adverse effects ; Disease Models, Animal ; Female ; Humans ; Male ; Mice, Transgenic ; Tumor Suppressor Protein p53/physiology
Czasopismo naukowe
Tytuł :
Circ_0010220-mediated miR-503-5p/CDCA4 axis contributes to osteosarcoma progression tumorigenesis.
Autorzy :
Li J; Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, PR China. Electronic address: .
Zhang F; Department of Anesthesiology, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei, PR China.
Li H; Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, PR China.
Peng F; Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, PR China.
Wang Z; Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, PR China.
Peng H; Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, PR China.
He J; Department of Orthopedics, General Hospital of the Yangtze River Shipping, Wuhan 430010, Hubei, PR China.
Li Y; Physical Examination Center, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, PR China.
He L; Physical Examination Center, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, PR China.
Wei L; School of Health Sciences, Wuhan University, Wuhan 430014, Hubei, PR China.
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Źródło :
Gene [Gene] 2020 Dec 30; Vol. 763, pp. 145068. Date of Electronic Publication: 2020 Aug 19.
Typ publikacji :
Journal Article
MeSH Terms :
Bone Neoplasms/*genetics
Cell Cycle Proteins/*genetics
MicroRNAs/*genetics
Osteosarcoma/*genetics
RNA, Circular/*genetics
Animals ; Apoptosis ; Bone Neoplasms/metabolism ; Bone Neoplasms/pathology ; Carcinogenesis/genetics ; Carcinogenesis/metabolism ; Cell Cycle Proteins/metabolism ; Cell Line, Tumor ; Cell Proliferation ; G1 Phase Cell Cycle Checkpoints ; Gene Expression Regulation, Neoplastic ; Humans ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; MicroRNAs/metabolism ; Osteosarcoma/metabolism ; Osteosarcoma/pathology ; RNA, Circular/metabolism
Czasopismo naukowe
Tytuł :
Development of a Polo-like Kinase-1 Polo-Box Domain Inhibitor as a Tumor Growth Suppressor in Mice Models.
Autorzy :
Gunasekaran P; Division of Magnetic Resonance, Korea Basic Science Institute (KBSI), Ochang, Chung Buk 28119, Republic of Korea.
Yim MS; Division of Magnetic Resonance, Korea Basic Science Institute (KBSI), Ochang, Chung Buk 28119, Republic of Korea.; Department of Bio-analytical Science, University of Science & Technology, Daejeon 34113, Republic of Korea.
Ahn M; Division of Magnetic Resonance, Korea Basic Science Institute (KBSI), Ochang, Chung Buk 28119, Republic of Korea.
Soung NK; Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanji-ro, Ochang, Cheongwon, Chungbuk 28116, Republic of Korea.
Park JE; Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, United States.
Kim J; Division of Magnetic Resonance, Korea Basic Science Institute (KBSI), Ochang, Chung Buk 28119, Republic of Korea.
Bang G; Biomedical Omics Group, Korea Basic Science Institute, Ochang, Chung-Buk 363-883, Republic of Korea.
Shin SC; Biomedical Research Institute, Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul 02792, Republic of Korea.
Choi J; Division of Magnetic Resonance, Korea Basic Science Institute (KBSI), Ochang, Chung Buk 28119, Republic of Korea.
Kim M; College of Pharmacy, Dongguk University, 52 Dongguk-ro, Ilsandong-gu, Goyang 10320, Republic of Korea.
Kim HN; Division of Magnetic Resonance, Korea Basic Science Institute (KBSI), Ochang, Chung Buk 28119, Republic of Korea.
Lee YH; Division of Magnetic Resonance, Korea Basic Science Institute (KBSI), Ochang, Chung Buk 28119, Republic of Korea.; Department of Bio-analytical Science, University of Science & Technology, Daejeon 34113, Republic of Korea.
Chung YH; Drug & Disease Target Research Team, Korea Basic Science Institute (KBSI), Ochang, Chung Buk 28119, Republic of Korea.
Lee K; College of Pharmacy, Dongguk University, 52 Dongguk-ro, Ilsandong-gu, Goyang 10320, Republic of Korea.
EunKyeong Kim E; Biomedical Research Institute, Korea Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul 02792, Republic of Korea.
Jeon YH; Laboratory of Biochemistry and Structural Biology, College of Pharmacy, Korea University, Sejong 30019, Republic of Korea.
Kim MJ; Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanji-ro, Ochang, Cheongwon, Chungbuk 28116, Republic of Korea.
Lee KR; Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanji-ro, Ochang, Cheongwon, Chungbuk 28116, Republic of Korea.
Kim BY; Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology, 30 Yeongudanji-ro, Ochang, Cheongwon, Chungbuk 28116, Republic of Korea.
Lee KS; Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, United States.
Ryu EK; Division of Magnetic Resonance, Korea Basic Science Institute (KBSI), Ochang, Chung Buk 28119, Republic of Korea.; Department of Bio-analytical Science, University of Science & Technology, Daejeon 34113, Republic of Korea.
Bang JK; Division of Magnetic Resonance, Korea Basic Science Institute (KBSI), Ochang, Chung Buk 28119, Republic of Korea.; Department of Bio-analytical Science, University of Science & Technology, Daejeon 34113, Republic of Korea.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2020 Dec 10; Vol. 63 (23), pp. 14905-14920. Date of Electronic Publication: 2020 Nov 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Antineoplastic Agents/*therapeutic use
Barbiturates/*therapeutic use
Cell Cycle Proteins/*antagonists & inhibitors
Neoplasms/*drug therapy
Protein Kinase Inhibitors/*therapeutic use
Protein-Serine-Threonine Kinases/*antagonists & inhibitors
Proto-Oncogene Proteins/*antagonists & inhibitors
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/metabolism ; Antineoplastic Agents/pharmacokinetics ; Apoptosis/drug effects ; Barbiturates/chemical synthesis ; Barbiturates/metabolism ; Barbiturates/pharmacokinetics ; Carbocyanines/chemistry ; Cell Cycle Proteins/metabolism ; Drug Design ; Drug Screening Assays, Antitumor ; Fluorescent Dyes/chemistry ; G2 Phase Cell Cycle Checkpoints/drug effects ; HeLa Cells ; Humans ; Male ; Mice, Inbred BALB C ; Mice, Inbred ICR ; Molecular Structure ; Neoplasms/diagnosis ; Protein Binding ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/metabolism ; Protein Kinase Inhibitors/pharmacokinetics ; Protein-Serine-Threonine Kinases/metabolism ; Proto-Oncogene Proteins/metabolism ; Structure-Activity Relationship ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Separable functions of Tof1/Timeless in intra-S-checkpoint signalling, replisome stability and DNA topological stress.
Autorzy :
Westhorpe R; Genome Damage and Stability Centre, School of Life Sciences, Science Park Road, University of Sussex, Falmer, Brighton, East Sussex BN1 9RQ, UK.
Keszthelyi A; Genome Damage and Stability Centre, School of Life Sciences, Science Park Road, University of Sussex, Falmer, Brighton, East Sussex BN1 9RQ, UK.
Minchell NE; Genome Damage and Stability Centre, School of Life Sciences, Science Park Road, University of Sussex, Falmer, Brighton, East Sussex BN1 9RQ, UK.
Jones D; Genome Damage and Stability Centre, School of Life Sciences, Science Park Road, University of Sussex, Falmer, Brighton, East Sussex BN1 9RQ, UK.
Baxter J; Genome Damage and Stability Centre, School of Life Sciences, Science Park Road, University of Sussex, Falmer, Brighton, East Sussex BN1 9RQ, UK.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Dec 02; Vol. 48 (21), pp. 12169-12187.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Fungal*
Cell Cycle Proteins/*genetics
DNA-Binding Proteins/*genetics
Saccharomyces cerevisiae/*genetics
Saccharomyces cerevisiae Proteins/*genetics
Cell Cycle Checkpoints/genetics ; Cell Cycle Proteins/metabolism ; DNA Replication ; DNA-Binding Proteins/metabolism ; Mutation ; Plasmids/chemistry ; Plasmids/metabolism ; Protein Binding ; Protein Domains ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/metabolism
Czasopismo naukowe

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