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Tytuł :
Desert Hedgehog-Driven Endothelium Integrity Is Enhanced by Gas1 (Growth Arrest-Specific 1) but Negatively Regulated by Cdon (Cell Adhesion Molecule-Related/Downregulated by Oncogenes).
Autorzy :
Chapouly C; University of Bordeaux, Inserm, Biology of Cardiovascular Diseases, U1034, F-33604 Pessac, France.
Hollier PL; University of Bordeaux, Inserm, Biology of Cardiovascular Diseases, U1034, F-33604 Pessac, France.
Guimbal S; University of Bordeaux, Inserm, Biology of Cardiovascular Diseases, U1034, F-33604 Pessac, France.
Cornuault L; University of Bordeaux, Inserm, Biology of Cardiovascular Diseases, U1034, F-33604 Pessac, France.
Gadeau AP; University of Bordeaux, Inserm, Biology of Cardiovascular Diseases, U1034, F-33604 Pessac, France.
Renault MA; University of Bordeaux, Inserm, Biology of Cardiovascular Diseases, U1034, F-33604 Pessac, France.
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Źródło :
Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2020 Dec; Vol. 40 (12), pp. e336-e349. Date of Electronic Publication: 2020 Oct 08.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Blood-Brain Barrier/*metabolism
Cell Adhesion Molecules/*metabolism
Cell Cycle Proteins/*metabolism
Corneal Neovascularization/*metabolism
Endothelial Cells/*metabolism
Endothelium, Corneal/*metabolism
Hedgehog Proteins/*metabolism
Inflammation/*metabolism
Animals ; Antigens, CD/genetics ; Antigens, CD/metabolism ; Blood-Brain Barrier/pathology ; Cadherins/genetics ; Cadherins/metabolism ; Cell Adhesion Molecules/deficiency ; Cell Adhesion Molecules/genetics ; Cell Cycle Proteins/deficiency ; Cell Cycle Proteins/genetics ; Cells, Cultured ; Corneal Neovascularization/genetics ; Corneal Neovascularization/pathology ; Disease Models, Animal ; Endothelial Cells/pathology ; Endothelium, Corneal/pathology ; Female ; GPI-Linked Proteins/deficiency ; GPI-Linked Proteins/genetics ; GPI-Linked Proteins/metabolism ; Hedgehog Proteins/genetics ; Humans ; Inflammation/genetics ; Inflammation/pathology ; Male ; Mice, 129 Strain ; Mice, Inbred C57BL ; Mice, Knockout ; Patched-1 Receptor/metabolism ; Signal Transduction ; Smoothened Receptor/metabolism
Czasopismo naukowe
Tytuł :
PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia.
Autorzy :
Monroe TO; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA.; Advanced Center for Translational and Genetic Medicine (ACT-GeM), Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 60611, USA.
Garrett ME; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, 27701, USA.
Kousi M; MIT Computer Science and Artificial Intelligence Laboratory (CSAIL), Broad Institute of MIT and Harvard, Cambridge, MA, 02139, USA.
Rodriguiz RM; Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, 27710, USA.; Mouse Behavioral and Neuroendocrine Analysis Core Facility, Duke University School of Medicine, Durham, NC, 27710, USA.
Moon S; Department of Biological Sciences, Kangwon National University, Chuncheon, 24341, Republic of Korea.
Bai Y; Department of Cell Biology, Duke University School of Medicine, Durham, NC, 27710, USA.
Brodar SC; Department of Cell Biology, Duke University School of Medicine, Durham, NC, 27710, USA.
Soldano KL; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, 27701, USA.
Savage J; Center for Translational Data Science, The University of Chicago, Chicago, IL, 60615, USA.
Hansen TF; Department of Clinical Sciences, University of Copenhagen, Copenhagen, Denmark.; Institute of Biological Psychiatry, MHC Sct. Hans, Mental Health Services, Copenhagen, Denmark.
Muzny DM; Human Genome Sequencing Center, Baylor College of Medicine, Houston, 77030, TX, USA.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.
Gibbs RA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, 77030, TX, USA.; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 77030, USA.
Barak L; Department of Cell Biology, Duke University School of Medicine, Durham, NC, 27710, USA.
Sullivan PF; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.; Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, SE-171 77, Sweden.
Ashley-Koch AE; Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, 27701, USA.
Sawa A; Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.; Department of Mental Health, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA.
Wetsel WC; Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, 27710, USA.; Mouse Behavioral and Neuroendocrine Analysis Core Facility, Duke University School of Medicine, Durham, NC, 27710, USA.; Department of Cell Biology, Duke University School of Medicine, Durham, NC, 27710, USA.; Department of Neurobiology, Duke University School of Medicine, Durham, NC, 27710, USA.
Werge T; Department of Clinical Sciences, University of Copenhagen, Copenhagen, Denmark.; Institute of Biological Psychiatry, MHC Sct. Hans, Mental Health Services, Copenhagen, Denmark.; iPSYCH - The Lundbeck Foundation Initiative for Integrative Psychiatric Research, Copenhagen, Denmark.; Center for GeoGenetics, GLOBE Institute, University of Copenhagen, Copenhagen, Denmark.
Katsanis N; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA. .; Advanced Center for Translational and Genetic Medicine (ACT-GeM), Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 60611, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Nov 19; Vol. 11 (1), pp. 5903. Date of Electronic Publication: 2020 Nov 19.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Cycle Proteins/*physiology
Cilia/*pathology
Genetic Predisposition to Disease/*genetics
Schizophrenia/*genetics
Adult ; Aged ; Alleles ; Amines/metabolism ; Animals ; Antipsychotic Agents/therapeutic use ; Brain/metabolism ; Brain/pathology ; Brain/physiopathology ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Cilia/metabolism ; Drug Resistance/genetics ; Humans ; Mice ; Mice, Knockout ; Middle Aged ; Mutation ; Phenotype ; Receptors, Dopamine D2/genetics ; Receptors, Dopamine D2/metabolism ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism ; Schizophrenia/drug therapy ; Schizophrenia/pathology ; Schizophrenia/physiopathology ; Signal Transduction ; Young Adult ; Zebrafish
Czasopismo naukowe
Tytuł :
Microcephalin 1/BRIT1-TRF2 interaction promotes telomere replication and repair, linking telomere dysfunction to primary microcephaly.
Autorzy :
Cicconi A; Department of Laboratory Medicine, Yale University School of Medicine, 330 Cedar St., New Haven, CT, 06520, USA.
Rai R; Department of Laboratory Medicine, Yale University School of Medicine, 330 Cedar St., New Haven, CT, 06520, USA.
Xiong X; State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, 200031, China.
Broton C; Department of Laboratory Medicine, Yale University School of Medicine, 330 Cedar St., New Haven, CT, 06520, USA.; Tri- Institutional MD/PhD Program, Weill Cornell Medical College, New York, NY, 10065, USA.
Al-Hiyasat A; Department of Laboratory Medicine, Yale University School of Medicine, 330 Cedar St., New Haven, CT, 06520, USA.; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, 330 Cedar St., New Haven, CT, 06520, USA.
Hu C; State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, 200031, China.
Dong S; State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, 200031, China.
Sun W; State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, 200031, China.
Garbarino J; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, 330 Cedar St., New Haven, CT, 06520, USA.; Department of Therapeutic Radiology, Yale University School of Medicine, 330 Cedar St., New Haven, CT, 06520, USA.
Bindra RS; Department of Therapeutic Radiology, Yale University School of Medicine, 330 Cedar St., New Haven, CT, 06520, USA.; Department of Experimental Pathology, Yale University School of Medicine, 330 Cedar St., New Haven, CT, 06520, USA.
Schildkraut C; Department of Cell Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, USA.
Chen Y; State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, 200031, China. .
Chang S; Department of Laboratory Medicine, Yale University School of Medicine, 330 Cedar St., New Haven, CT, 06520, USA. .; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, 330 Cedar St., New Haven, CT, 06520, USA. .; Department of Pathology, Yale University School of Medicine, 330 Cedar St., New Haven, CT, 06520, USA. .
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Źródło :
Nature communications [Nat Commun] 2020 Nov 17; Vol. 11 (1), pp. 5861. Date of Electronic Publication: 2020 Nov 17.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Cell Cycle Proteins/*metabolism
Cytoskeletal Proteins/*metabolism
Microcephaly/*genetics
Telomere/*genetics
Telomeric Repeat Binding Protein 2/*metabolism
Aminopeptidases/genetics ; Aminopeptidases/metabolism ; Animals ; Binding Sites ; Calorimetry ; Cell Cycle Proteins/chemistry ; Cell Cycle Proteins/genetics ; Cytoskeletal Proteins/chemistry ; Cytoskeletal Proteins/genetics ; DNA Damage ; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases/genetics ; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases/metabolism ; Fibroblasts ; HeLa Cells ; Histones/genetics ; Histones/metabolism ; Humans ; Mice ; Mutation ; Protein Interaction Domains and Motifs ; Serine Proteases/genetics ; Serine Proteases/metabolism ; Telomere/metabolism ; Telomere-Binding Proteins/genetics ; Telomere-Binding Proteins/metabolism ; Telomeric Repeat Binding Protein 2/chemistry ; Telomeric Repeat Binding Protein 2/genetics
Czasopismo naukowe
Tytuł :
Effect of PIERCE1 on colorectal cancer.
Autorzy :
Park BM; Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Yonsei Ro 50, Seodaemun-gu, Seoul 03722, Republic of Korea.
Kim HJ; Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Yonsei Ro 50, Seodaemun-gu, Seoul 03722, Republic of Korea.
Oh JH; Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Yonsei Ro 50, Seodaemun-gu, Seoul 03722, Republic of Korea.
Roh JI; Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Yonsei Ro 50, Seodaemun-gu, Seoul 03722, Republic of Korea.
Lee HW; Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Yonsei Ro 50, Seodaemun-gu, Seoul 03722, Republic of Korea.
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Źródło :
Experimental animals [Exp Anim] 2020 Nov 12; Vol. 69 (4), pp. 414-422. Date of Electronic Publication: 2020 Jun 25.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression*
Cell Cycle Proteins/*genetics
Cell Cycle Proteins/*metabolism
Colorectal Neoplasms/*genetics
Animals ; Azoxymethane/adverse effects ; Cell Cycle/genetics ; Cell Cycle Proteins/physiology ; Cell Line, Tumor ; Cell Proliferation/genetics ; Colorectal Neoplasms/chemically induced ; Colorectal Neoplasms/pathology ; Dextran Sulfate/adverse effects ; Disease Models, Animal ; Female ; Humans ; Male ; Mice, Transgenic ; Tumor Suppressor Protein p53/physiology
Czasopismo naukowe
Tytuł :
Insights into bacterial cell division from a structure of EnvC bound to the FtsX periplasmic domain.
Autorzy :
Cook J; School of Life Sciences, University of Warwick, Coventry, CV4 7AL, United Kingdom.
Baverstock TC; School of Life Sciences, University of Warwick, Coventry, CV4 7AL, United Kingdom.
McAndrew MBL; School of Life Sciences, University of Warwick, Coventry, CV4 7AL, United Kingdom.; Warwick Medical School, University of Warwick, Coventry, CV4 7AL, United Kingdom.; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, United Kingdom.
Stansfeld PJ; School of Life Sciences, University of Warwick, Coventry, CV4 7AL, United Kingdom.; Department of Chemistry, University of Warwick, Coventry, CV4 7AL, United Kingdom.
Roper DI; School of Life Sciences, University of Warwick, Coventry, CV4 7AL, United Kingdom.
Crow A; School of Life Sciences, University of Warwick, Coventry, CV4 7AL, United Kingdom; .
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Źródło :
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Nov 10; Vol. 117 (45), pp. 28355-28365. Date of Electronic Publication: 2020 Oct 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Bacteria/*metabolism
Bacterial Proteins/*chemistry
Cell Cycle Proteins/*chemistry
Cell Division/*physiology
Endopeptidases/*chemistry
Periplasm/*metabolism
ATP-Binding Cassette Transporters/metabolism ; Bacterial Proteins/metabolism ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Cell Membrane/metabolism ; Crystallography, X-Ray ; DNA Mutational Analysis ; Endopeptidases/metabolism ; Escherichia coli/metabolism ; Escherichia coli Proteins ; Models, Molecular ; Mutation ; N-Acetylmuramoyl-L-alanine Amidase/genetics ; N-Acetylmuramoyl-L-alanine Amidase/metabolism ; Periplasm/chemistry ; Protein Binding ; Protein Conformation ; Protein Domains ; Protein Interaction Domains and Motifs
Czasopismo naukowe
Tytuł :
Functionally non-redundant paralogs spe-47 and spe-50 encode FB-MO associated proteins and interact with him-8.
Autorzy :
Clark JN; Department of Biological Sciences, Cal Poly Pomona, Pomona, California, United States of America.
Prajapati G; Department of Biological Sciences, Cal Poly Pomona, Pomona, California, United States of America.
Aldaco FK; Department of Biological Sciences, Cal Poly Pomona, Pomona, California, United States of America.
Sokolich TJ; Department of Biological Sciences, Cal Poly Pomona, Pomona, California, United States of America.
Keung SS; Department of Biological Sciences, Cal Poly Pomona, Pomona, California, United States of America.
Austin SP; Department of Biological Sciences, Cal Poly Pomona, Pomona, California, United States of America.
Valdés ÁA; Department of Biological Sciences, Cal Poly Pomona, Pomona, California, United States of America.
LaMunyon CW; Department of Biological Sciences, Cal Poly Pomona, Pomona, California, United States of America.
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Źródło :
PloS one [PLoS One] 2020 Dec 31; Vol. 15 (12), pp. e0230939. Date of Electronic Publication: 2020 Dec 31 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Caenorhabditis elegans/*genetics
Caenorhabditis elegans Proteins/*genetics
Cell Cycle Proteins/*genetics
Spermatids/*metabolism
Spermatozoa/*metabolism
Amino Acid Sequence ; Animals ; Caenorhabditis elegans/classification ; Caenorhabditis elegans/metabolism ; Caenorhabditis elegans Proteins/metabolism ; Cell Cycle Proteins/metabolism ; Cell Differentiation ; Conserved Sequence ; Gene Duplication ; Gene Expression ; Gene Knockout Techniques ; Genetic Speciation ; Hermaphroditic Organisms ; Male ; Mutation ; Phylogeny ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Sequence Alignment ; Sequence Homology, Amino Acid ; Sperm Count ; Spermatids/cytology ; Spermatids/growth & development ; Spermatozoa/cytology ; Spermatozoa/growth & development
Czasopismo naukowe
Tytuł :
Circ_0010220-mediated miR-503-5p/CDCA4 axis contributes to osteosarcoma progression tumorigenesis.
Autorzy :
Li J; Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, PR China. Electronic address: .
Zhang F; Department of Anesthesiology, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei, PR China.
Li H; Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, PR China.
Peng F; Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, PR China.
Wang Z; Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, PR China.
Peng H; Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, PR China.
He J; Department of Orthopedics, General Hospital of the Yangtze River Shipping, Wuhan 430010, Hubei, PR China.
Li Y; Physical Examination Center, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, PR China.
He L; Physical Examination Center, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, PR China.
Wei L; School of Health Sciences, Wuhan University, Wuhan 430014, Hubei, PR China.
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Źródło :
Gene [Gene] 2020 Dec 30; Vol. 763, pp. 145068. Date of Electronic Publication: 2020 Aug 19.
Typ publikacji :
Journal Article
MeSH Terms :
Bone Neoplasms/*genetics
Cell Cycle Proteins/*genetics
MicroRNAs/*genetics
Osteosarcoma/*genetics
RNA, Circular/*genetics
Animals ; Apoptosis ; Bone Neoplasms/metabolism ; Bone Neoplasms/pathology ; Carcinogenesis/genetics ; Carcinogenesis/metabolism ; Cell Cycle Proteins/metabolism ; Cell Line, Tumor ; Cell Proliferation ; G1 Phase Cell Cycle Checkpoints ; Gene Expression Regulation, Neoplastic ; Humans ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; MicroRNAs/metabolism ; Osteosarcoma/metabolism ; Osteosarcoma/pathology ; RNA, Circular/metabolism
Czasopismo naukowe
Tytuł :
Gadd45α affects retinal ganglion cell injury in chronic ocular hypertension rats by regulating p38MAPK pathway.
Autorzy :
Sun RX; Department of Ophthalmology, The First Hospital of Shijiazhuang City, Shijiazhuang 050000, Hebei Province, China.
Sun ZH; Department of Ophthalmology, The First Hospital of Shijiazhuang City, Shijiazhuang 050000, Hebei Province, China.
Ren Q; Department of Ophthalmology, The First Hospital of Shijiazhuang City, Shijiazhuang 050000, Hebei Province, China.
Li L; Department of Ophthalmology, The First Hospital of Shijiazhuang City, Shijiazhuang 050000, Hebei Province, China.
Yin L; Department of Ophthalmology, The First Hospital of Shijiazhuang City, Shijiazhuang 050000, Hebei Province, China.
Li F; Department of Ophthalmology, The First Hospital of Shijiazhuang City, Shijiazhuang 050000, Hebei Province, China.
Su X; Department of Ophthalmology, The First Hospital of Shijiazhuang City, Shijiazhuang 050000, Hebei Province, China. Electronic address: .
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Źródło :
Gene [Gene] 2020 Dec 30; Vol. 763, pp. 145030. Date of Electronic Publication: 2020 Aug 02.
Typ publikacji :
Journal Article
MeSH Terms :
MAP Kinase Signaling System*
Cell Cycle Proteins/*metabolism
Ocular Hypertension/*metabolism
Retinal Ganglion Cells/*metabolism
p38 Mitogen-Activated Protein Kinases/*metabolism
Animals ; Apoptosis ; Cell Cycle Proteins/genetics ; Cells, Cultured ; Humans ; Male ; Oxidative Stress ; Rats ; Rats, Sprague-Dawley
Czasopismo naukowe
Tytuł :
Purified Smc5/6 Complex Exhibits DNA Substrate Recognition and Compaction.
Autorzy :
Gutierrez-Escribano P; Cell Cycle Group, MRC London Institute of Medical Sciences (LMS), Du Cane Road, London W12 0NN, UK.
Hormeño S; Department of Macromolecular Structures, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas, Madrid, Spain.
Madariaga-Marcos J; Department of Macromolecular Structures, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas, Madrid, Spain.
Solé-Soler R; Institut de Recerca Biomèdica de Lleida (IRBLLEIDA), Department of Ciències Mèdiques Bàsiques, Universitat de Lleida, Lleida, Spain.
O'Reilly FJ; Bioanalytics, Institute of Biotechnology, Technische Universität Berlin, 13355 Berlin, Germany; Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3BF, UK.
Morris K; Microscopy Facility, MRC London Institute of Medical Sciences (LMS), Du Cane Road, London W12 0NN, UK.
Aicart-Ramos C; Department of Macromolecular Structures, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas, Madrid, Spain.
Aramayo R; Microscopy Facility, MRC London Institute of Medical Sciences (LMS), Du Cane Road, London W12 0NN, UK.
Montoya A; Biological Mass Spectrometry and Proteomics Facility, MRC London Institute of Medical Sciences (LMS), Du Cane Road, London W12 0NN, UK.
Kramer H; Biological Mass Spectrometry and Proteomics Facility, MRC London Institute of Medical Sciences (LMS), Du Cane Road, London W12 0NN, UK.
Rappsilber J; Bioanalytics, Institute of Biotechnology, Technische Universität Berlin, 13355 Berlin, Germany; Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh EH9 3BF, UK.
Torres-Rosell J; Institut de Recerca Biomèdica de Lleida (IRBLLEIDA), Department of Ciències Mèdiques Bàsiques, Universitat de Lleida, Lleida, Spain.
Moreno-Herrero F; Department of Macromolecular Structures, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas, Madrid, Spain. Electronic address: .
Aragon L; Cell Cycle Group, MRC London Institute of Medical Sciences (LMS), Du Cane Road, London W12 0NN, UK. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Dec 17; Vol. 80 (6), pp. 1039-1054.e6. Date of Electronic Publication: 2020 Dec 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Cycle Proteins/*genetics
Multiprotein Complexes/*genetics
Saccharomyces cerevisiae/*genetics
Saccharomyces cerevisiae Proteins/*genetics
Adenosine Triphosphatases/genetics ; Biophysical Phenomena ; Cell Cycle Proteins/ultrastructure ; Chromosomal Proteins, Non-Histone/genetics ; Chromosomal Proteins, Non-Histone/ultrastructure ; DNA-Binding Proteins/genetics ; Humans ; Interphase/genetics ; Mitosis/genetics ; Multiprotein Complexes/ultrastructure ; Saccharomyces cerevisiae/ultrastructure ; Saccharomyces cerevisiae Proteins/ultrastructure ; Sumoylation/genetics
Czasopismo naukowe
Tytuł :
TRIB3 promotes MYC-associated lymphoma development through suppression of UBE3B-mediated MYC degradation.
Autorzy :
Li K; National Clinical Research Center for Metabolic Disease, Department of Metabolism and Endocrinology, the Second Xiangya Hospital, Central South University, 410011, Changsha, Hunan, China.; NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, 100050, Beijing, China.
Wang F; Immunology and Cancer Pharmacology Group, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, 100050, Beijing, China.
Yang ZN; Immunology and Cancer Pharmacology Group, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, 100050, Beijing, China.
Zhang TT; Immunology and Cancer Pharmacology Group, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, 100050, Beijing, China.
Yuan YF; Anyang Tumor Hospital, Henan University of Science and Technology, 300020, Anyang, China.
Zhao CX; Immunology and Cancer Pharmacology Group, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, 100050, Beijing, China.
Yeerjiang Z; Immunology and Cancer Pharmacology Group, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, 100050, Beijing, China.
Cui B; Immunology and Cancer Pharmacology Group, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, 100050, Beijing, China.
Hua F; Immunology and Cancer Pharmacology Group, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, 100050, Beijing, China.
Lv XX; Immunology and Cancer Pharmacology Group, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, 100050, Beijing, China.
Zhang XW; Immunology and Cancer Pharmacology Group, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, 100050, Beijing, China.
Yu JJ; Immunology and Cancer Pharmacology Group, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, 100050, Beijing, China.
Liu SS; Immunology and Cancer Pharmacology Group, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, 100050, Beijing, China.
Yu JM; Immunology and Cancer Pharmacology Group, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, 100050, Beijing, China.
Shang S; Immunology and Cancer Pharmacology Group, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, 100050, Beijing, China.
Xiao Y; National Clinical Research Center for Metabolic Disease, Department of Metabolism and Endocrinology, the Second Xiangya Hospital, Central South University, 410011, Changsha, Hunan, China.
Hu ZW; National Clinical Research Center for Metabolic Disease, Department of Metabolism and Endocrinology, the Second Xiangya Hospital, Central South University, 410011, Changsha, Hunan, China. .; Immunology and Cancer Pharmacology Group, State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, 100050, Beijing, China. .
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Źródło :
Nature communications [Nat Commun] 2020 Dec 09; Vol. 11 (1), pp. 6316. Date of Electronic Publication: 2020 Dec 09.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Cycle Proteins/*metabolism
Lymphoma, Non-Hodgkin/*pathology
Protein-Serine-Threonine Kinases/*antagonists & inhibitors
Proto-Oncogene Proteins c-myc/*metabolism
Repressor Proteins/*metabolism
Ubiquitin-Protein Ligases/*metabolism
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Cell Cycle Proteins/genetics ; Cell Line, Tumor ; Cell Self Renewal/drug effects ; Cell Self Renewal/genetics ; Chromatin Immunoprecipitation Sequencing ; Disease Progression ; Female ; Gene Expression Regulation, Neoplastic ; Gene Knock-In Techniques ; Gene Knockdown Techniques ; HEK293 Cells ; Humans ; Lymphoma, Non-Hodgkin/drug therapy ; Lymphoma, Non-Hodgkin/genetics ; Male ; Mice ; Mice, Knockout ; Middle Aged ; Primary Cell Culture ; Proteasome Endopeptidase Complex/metabolism ; Proteasome Inhibitors/pharmacology ; Protein-Serine-Threonine Kinases/genetics ; Protein-Serine-Threonine Kinases/metabolism ; Proteolysis/drug effects ; Proto-Oncogene Proteins c-myc/antagonists & inhibitors ; RNA-Seq ; Repressor Proteins/genetics ; Ubiquitination/drug effects ; Ubiquitination/genetics ; Xenograft Model Antitumor Assays ; Young Adult
Czasopismo naukowe
Tytuł :
VEZF1-guanine quadruplex DNA interaction regulates alternative polyadenylation and detyrosinase activity of VASH1.
Autorzy :
Li L; Department of Chemistry, University of California, Riverside, CA 92521, USA.
Williams P; Department of Chemistry, University of California, Riverside, CA 92521, USA.
Gao Z; Department of Chemistry, University of California, Riverside, CA 92521, USA.
Wang Y; Department of Chemistry, University of California, Riverside, CA 92521, USA.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Dec 02; Vol. 48 (21), pp. 11994-12003.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
G-Quadruplexes*
Cell Cycle Proteins/*genetics
DNA/*genetics
DNA-Binding Proteins/*genetics
Guanine/*metabolism
Neovascularization, Physiologic/*genetics
Transcription Factors/*genetics
Cell Cycle Proteins/metabolism ; Chromatin/chemistry ; Chromatin/metabolism ; DNA/chemistry ; DNA/metabolism ; DNA-Binding Proteins/metabolism ; Gene Expression Regulation ; Guanine/chemistry ; HEK293 Cells ; Human Umbilical Vein Endothelial Cells ; Humans ; Polyadenylation ; Protein Binding ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Signal Transduction ; Transcription Factors/metabolism ; Transcription, Genetic ; Tubulin/genetics ; Tubulin/metabolism
Czasopismo naukowe
Tytuł :
Separable functions of Tof1/Timeless in intra-S-checkpoint signalling, replisome stability and DNA topological stress.
Autorzy :
Westhorpe R; Genome Damage and Stability Centre, School of Life Sciences, Science Park Road, University of Sussex, Falmer, Brighton, East Sussex BN1 9RQ, UK.
Keszthelyi A; Genome Damage and Stability Centre, School of Life Sciences, Science Park Road, University of Sussex, Falmer, Brighton, East Sussex BN1 9RQ, UK.
Minchell NE; Genome Damage and Stability Centre, School of Life Sciences, Science Park Road, University of Sussex, Falmer, Brighton, East Sussex BN1 9RQ, UK.
Jones D; Genome Damage and Stability Centre, School of Life Sciences, Science Park Road, University of Sussex, Falmer, Brighton, East Sussex BN1 9RQ, UK.
Baxter J; Genome Damage and Stability Centre, School of Life Sciences, Science Park Road, University of Sussex, Falmer, Brighton, East Sussex BN1 9RQ, UK.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2020 Dec 02; Vol. 48 (21), pp. 12169-12187.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Expression Regulation, Fungal*
Cell Cycle Proteins/*genetics
DNA-Binding Proteins/*genetics
Saccharomyces cerevisiae/*genetics
Saccharomyces cerevisiae Proteins/*genetics
Cell Cycle Checkpoints/genetics ; Cell Cycle Proteins/metabolism ; DNA Replication ; DNA-Binding Proteins/metabolism ; Mutation ; Plasmids/chemistry ; Plasmids/metabolism ; Protein Binding ; Protein Domains ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/metabolism
Czasopismo naukowe
Tytuł :
Cohesin depleted cells rebuild functional nuclear compartments after endomitosis.
Autorzy :
Cremer M; Anthropology and Human Genomics, Department Biology II, Ludwig-Maximilians-Universität München, München, Germany. .
Brandstetter K; Human Biology & BioImaging, Center for Molecular Biosystems, Department Biology II, Ludwig-Maximilians-Universität München, München, Germany.
Maiser A; Human Biology & BioImaging, Center for Molecular Biosystems, Department Biology II, Ludwig-Maximilians-Universität München, München, Germany.
Rao SSP; Center for Genome Architecture, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.; Department of Structural Biology, Stanford University School of Medicine, California, USA.
Schmid VJ; Bayesian Imaging and Spatial Statistics Group, Department of Statistics, Ludwig-Maximilians-Universität München, München, Germany.
Guirao-Ortiz M; Human Biology & BioImaging, Center for Molecular Biosystems, Department Biology II, Ludwig-Maximilians-Universität München, München, Germany.
Mitra N; Center for Genome Architecture, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Mamberti S; Cell Biology and Epigenetics, Department of Biology, Technische Universität Darmstadt, Darmstadt, Germany.
Klein KN; Department of Biological Science, Florida State University, Tallahassee, FL, USA.
Gilbert DM; Department of Biological Science, Florida State University, Tallahassee, FL, USA.
Leonhardt H; Human Biology & BioImaging, Center for Molecular Biosystems, Department Biology II, Ludwig-Maximilians-Universität München, München, Germany.
Cardoso MC; Cell Biology and Epigenetics, Department of Biology, Technische Universität Darmstadt, Darmstadt, Germany.
Aiden EL; Center for Genome Architecture, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.; Center for Theoretical Biological Physics, Rice University, Houston, TX, USA.; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.; Departments of Computer Science and Computational and Applied Mathematics, Rice University, Houston, TX, USA.
Harz H; Human Biology & BioImaging, Center for Molecular Biosystems, Department Biology II, Ludwig-Maximilians-Universität München, München, Germany. .
Cremer T; Anthropology and Human Genomics, Department Biology II, Ludwig-Maximilians-Universität München, München, Germany. .
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Źródło :
Nature communications [Nat Commun] 2020 Dec 01; Vol. 11 (1), pp. 6146. Date of Electronic Publication: 2020 Dec 01.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Mitosis*
Cell Cycle Proteins/*metabolism
Chromosomal Proteins, Non-Histone/*metabolism
Cell Cycle Proteins/genetics ; Cell Line, Tumor ; Cell Nucleus/genetics ; Cell Nucleus/metabolism ; Chromatin/genetics ; Chromatin/metabolism ; Chromosomal Proteins, Non-Histone/genetics ; Humans ; S Phase
Czasopismo naukowe
Tytuł :
A specific inhibitor of polo-like kinase 1, GSK461364A, suppresses proliferation of Raji Burkitt's lymphoma cells through mediating cell cycle arrest, DNA damage, and apoptosis.
Autorzy :
Ergul M; Department of Biochemistry, Faculty of Pharmacy, Sivas Cumhuriyet University, Sivas, Turkey. Electronic address: .
Bakar-Ates F; Department of Biochemistry, Faculty of Pharmacy, Ankara University, Ankara, Turkey.
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Źródło :
Chemico-biological interactions [Chem Biol Interact] 2020 Dec 01; Vol. 332, pp. 109288. Date of Electronic Publication: 2020 Oct 17.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*/drug effects
DNA Damage*
Burkitt Lymphoma/*pathology
Cell Cycle Checkpoints/*drug effects
Cell Cycle Proteins/*antagonists & inhibitors
Protein Kinase Inhibitors/*pharmacology
Protein-Serine-Threonine Kinases/*antagonists & inhibitors
Proto-Oncogene Proteins/*antagonists & inhibitors
Thiophenes/*pharmacology
Animals ; Antioxidants/metabolism ; Cell Cycle Proteins/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; G2 Phase/drug effects ; Humans ; Mice ; Mitosis/drug effects ; Oxidants/metabolism ; Protein-Serine-Threonine Kinases/metabolism ; Proto-Oncogene Proteins/metabolism
Czasopismo naukowe
Tytuł :
Resveratrol ameliorates lipopolysaccharide-induced anxiety-like behavior by attenuating YAP-mediated neuro-inflammation and promoting hippocampal autophagy in mice.
Autorzy :
Tian Q; Institute of Hypoxia Medicine, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Fan X; Institute of Hypoxia Medicine, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Ma J; Institute of Hypoxia Medicine, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Han Y; Institute of Hypoxia Medicine, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Li D; Institute of Hypoxia Medicine, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Jiang S; Institute of Hypoxia Medicine, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Zhang F; Institute of Hypoxia Medicine, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Guang H; Institute of Hypoxia Medicine, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Shan X; Institute of Hypoxia Medicine, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Chen R; Institute of Hypoxia Medicine, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Wang P; Institute of Hypoxia Medicine, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Wang Q; Institute of Hypoxia Medicine, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Yang J; Department of Medical Technology, Jiangxi Medical College, Shangrao, Jiangxi 334709, China.
Wang Y; Institute of Hypoxia Medicine, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Hu L; Institute of Hypoxia Medicine, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Shentu Y; Department of Pathology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China. Electronic address: .
Gong Y; Institute of Hypoxia Medicine, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China. Electronic address: .
Fan J; Institute of Hypoxia Medicine, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China. Electronic address: .
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Źródło :
Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2020 Dec 01; Vol. 408, pp. 115261. Date of Electronic Publication: 2020 Oct 01.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Adaptor Proteins, Signal Transducing/*metabolism
Anti-Anxiety Agents/*therapeutic use
Anxiety/*drug therapy
Cell Cycle Proteins/*metabolism
Encephalitis/*drug therapy
Resveratrol/*therapeutic use
Adaptor Proteins, Signal Transducing/genetics ; Animals ; Anti-Anxiety Agents/pharmacology ; Anxiety/chemically induced ; Anxiety/genetics ; Anxiety/metabolism ; Autophagy/drug effects ; Behavior, Animal/drug effects ; Cell Cycle Proteins/genetics ; Encephalitis/chemically induced ; Encephalitis/genetics ; Encephalitis/metabolism ; Hippocampus/drug effects ; Hippocampus/metabolism ; Lipopolysaccharides ; Male ; Mice, Inbred C57BL ; Resveratrol/pharmacology
Czasopismo naukowe
Tytuł :
Expression of FOXO4 Inhibits Cholangiocarcinoma Cell Proliferation In Vitro via Induction of G 0 /G 1 Arrest.
Autorzy :
Intuyod K; Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.; Cholangiocarcinoma Research Institute, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Chomwong S; Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Thongpon P; Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.; Cholangiocarcinoma Research Institute, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Vaeteewoottacharn K; Cholangiocarcinoma Research Institute, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.; Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Pairojkul C; Cholangiocarcinoma Research Institute, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.; Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Pinlaor P; Cholangiocarcinoma Research Institute, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.; Centre for Research and Development in Medical Diagnostic Laboratory, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand.
Pinlaor S; Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand .; Cholangiocarcinoma Research Institute, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; .
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Źródło :
Anticancer research [Anticancer Res] 2020 Dec; Vol. 40 (12), pp. 6899-6905.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression*
Bile Duct Neoplasms/*genetics
Cell Cycle Proteins/*genetics
Cholangiocarcinoma/*genetics
Forkhead Transcription Factors/*genetics
G1 Phase Cell Cycle Checkpoints/*genetics
Cell Cycle Proteins/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Ectopic Gene Expression ; Forkhead Transcription Factors/metabolism ; Humans
Czasopismo naukowe
Tytuł :
Response to Comment on "Ancient origins of allosteric activation in a Ser-Thr kinase".
Autorzy :
Wilson C; Department of Biochemistry and Howard Hughes Medical Institute, Brandeis University, Waltham, MA 02453, USA.
Kern D; Department of Biochemistry and Howard Hughes Medical Institute, Brandeis University, Waltham, MA 02453, USA. .
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Źródło :
Science (New York, N.Y.) [Science] 2020 Nov 20; Vol. 370 (6519).
Typ publikacji :
Journal Article; Comment
MeSH Terms :
Cell Cycle Proteins*
Microtubule-Associated Proteins*
Protein-Serine-Threonine Kinases/genetics
Czasopismo naukowe
Tytuł :
Opposing Effects of Cohesin and Transcription on CTCF Organization Revealed by Super-resolution Imaging.
Autorzy :
Gu B; Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA.
Comerci CJ; Department of Chemistry, Stanford University, Stanford, CA, USA; Biophysics Program, Stanford University, Stanford, CA, USA.
McCarthy DG; Department of Chemistry, Stanford University, Stanford, CA, USA.
Saurabh S; Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA.
Moerner WE; Department of Chemistry, Stanford University, Stanford, CA, USA; Biophysics Program, Stanford University, Stanford, CA, USA. Electronic address: .
Wysocka J; Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA; Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Nov 19; Vol. 80 (4), pp. 699-711.e7. Date of Electronic Publication: 2020 Oct 21.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
MeSH Terms :
Transcription, Genetic*
CCCTC-Binding Factor/*metabolism
Cell Cycle Proteins/*metabolism
Chromatin/*metabolism
Chromosomal Proteins, Non-Histone/*metabolism
Embryonic Stem Cells/*cytology
Microscopy, Fluorescence/*methods
Proteins/*metabolism
Animals ; CCCTC-Binding Factor/genetics ; Cell Cycle Proteins/genetics ; Cells, Cultured ; Chromatin/genetics ; Chromosomal Proteins, Non-Histone/genetics ; Chromosomes, Mammalian ; Embryonic Stem Cells/metabolism ; Genetic Loci ; Genome ; Image Processing, Computer-Assisted ; Mice ; Proteins/genetics
Czasopismo naukowe
Tytuł :
Cancer-Associated Gain-of-Function Mutations Activate a SWI/SNF-Family Regulatory Hub.
Autorzy :
Clapier CR; Department of Oncological Sciences and Howard Hughes Medical Institute, University of Utah School of Medicine, Salt Lake City, UT 84112, USA; Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT 84112, USA. Electronic address: .
Verma N; Department of Oncological Sciences and Howard Hughes Medical Institute, University of Utah School of Medicine, Salt Lake City, UT 84112, USA; Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
Parnell TJ; Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
Cairns BR; Department of Oncological Sciences and Howard Hughes Medical Institute, University of Utah School of Medicine, Salt Lake City, UT 84112, USA; Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT 84112, USA. Electronic address: .
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Źródło :
Molecular cell [Mol Cell] 2020 Nov 19; Vol. 80 (4), pp. 712-725.e5. Date of Electronic Publication: 2020 Oct 14.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromatin Assembly and Disassembly*
Gain of Function Mutation*
Cell Cycle Proteins/*metabolism
Chromosomal Proteins, Non-Histone/*metabolism
Neoplasms/*pathology
Nuclear Proteins/*metabolism
Saccharomyces cerevisiae/*metabolism
Saccharomyces cerevisiae Proteins/*metabolism
Cell Cycle Proteins/genetics ; Chromosomal Proteins, Non-Histone/genetics ; DNA Helicases/genetics ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Humans ; Neoplasms/genetics ; Nuclear Proteins/genetics ; Nucleosomes ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/growth & development ; Saccharomyces cerevisiae Proteins/genetics ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Translocation, Genetic
Czasopismo naukowe
Tytuł :
Mus81-Mms4 endonuclease is an Esc2-STUbL-Cullin8 mitotic substrate impacting on genome integrity.
Autorzy :
Waizenegger A; IFOM, the FIRC Institute of Molecular Oncology, Via Adamello 16, 20139, Milan, Italy.
Urulangodi M; IFOM, the FIRC Institute of Molecular Oncology, Via Adamello 16, 20139, Milan, Italy.; Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST), Thiruvananthapuram, Kerala, 695011, India.
Lehmann CP; Centro de Biología Molecular Severo Ochoa (CSIC/UAM), Cantoblanco, 28049, Madrid, Spain.
Reyes TAC; IFOM, the FIRC Institute of Molecular Oncology, Via Adamello 16, 20139, Milan, Italy.
Saugar I; Centro de Biología Molecular Severo Ochoa (CSIC/UAM), Cantoblanco, 28049, Madrid, Spain.
Tercero JA; Centro de Biología Molecular Severo Ochoa (CSIC/UAM), Cantoblanco, 28049, Madrid, Spain.
Szakal B; IFOM, the FIRC Institute of Molecular Oncology, Via Adamello 16, 20139, Milan, Italy.
Branzei D; IFOM, the FIRC Institute of Molecular Oncology, Via Adamello 16, 20139, Milan, Italy. .; Istituto di Genetica Molecolare, Consiglio Nazionale delle Ricerche (IGM-CNR), Via Abbiategrasso 207, 27100, Pavia, Italy. .
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Źródło :
Nature communications [Nat Commun] 2020 Nov 12; Vol. 11 (1), pp. 5746. Date of Electronic Publication: 2020 Nov 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Cycle Proteins/*metabolism
DNA-Binding Proteins/*metabolism
Endonucleases/*metabolism
Flap Endonucleases/*metabolism
Mitosis/*physiology
Saccharomyces cerevisiae Proteins/*metabolism
Cell Cycle/physiology ; Cell Cycle Proteins/genetics ; Chromatin/metabolism ; Cullin Proteins/metabolism ; DNA Damage/physiology ; DNA Repair/physiology ; DNA Replication/physiology ; DNA-Binding Proteins/genetics ; Endonucleases/genetics ; Flap Endonucleases/genetics ; Gene Expression Regulation, Fungal ; Genomic Instability ; Mitosis/genetics ; Protein Processing, Post-Translational/genetics ; Protein Processing, Post-Translational/physiology ; Recombinational DNA Repair ; Saccharomyces cerevisiae Proteins/genetics ; Sumoylation ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination
Czasopismo naukowe

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