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Tytuł :
Inhibition of BRD4 Suppresses the Growth of Esophageal Squamous Cell Carcinoma.
Autorzy :
Niu H; Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, China.; Jiangsu Engineering Research Center for Tumor Immunotherapy, The Third Affiliated Hospital of Soochow University, Changzhou, China.; Department of Oncology, Lanzhou University Second Hospital, Lanzhou, China.; Institute of Cell Therapy, Soochow University, Changzhou, China.
Song F; Department of Oncology, Lanzhou University Second Hospital, Lanzhou, China.
Wei H; Department of Cardiology, The First People's Hospital of Lanzhou, Lanzhou, China.
Li Y; Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, China.; Jiangsu Engineering Research Center for Tumor Immunotherapy, The Third Affiliated Hospital of Soochow University, Changzhou, China.; Institute of Cell Therapy, Soochow University, Changzhou, China.
Huang H; Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, China.; Jiangsu Engineering Research Center for Tumor Immunotherapy, The Third Affiliated Hospital of Soochow University, Changzhou, China.; Institute of Cell Therapy, Soochow University, Changzhou, China.
Wu C; Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, China.; Jiangsu Engineering Research Center for Tumor Immunotherapy, The Third Affiliated Hospital of Soochow University, Changzhou, China.; Institute of Cell Therapy, Soochow University, Changzhou, China.; Department of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou, China.
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Źródło :
Cancer investigation [Cancer Invest] 2021 Nov; Vol. 39 (10), pp. 826-841. Date of Electronic Publication: 2021 Sep 14.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Cycle Proteins/*physiology
Esophageal Neoplasms/*pathology
Esophageal Squamous Cell Carcinoma/*pathology
Transcription Factors/*physiology
Adult ; Aged ; Aged, 80 and over ; Apoptosis/drug effects ; Cadherins/analysis ; Cell Cycle Proteins/analysis ; Cell Cycle Proteins/antagonists & inhibitors ; Cell Line, Tumor ; Cell Movement/drug effects ; Cell Proliferation ; Cyclin D1/analysis ; Epithelial-Mesenchymal Transition ; Esophageal Neoplasms/chemistry ; Esophageal Neoplasms/drug therapy ; Esophageal Squamous Cell Carcinoma/chemistry ; Esophageal Squamous Cell Carcinoma/drug therapy ; Female ; Humans ; Male ; Middle Aged ; Proto-Oncogene Proteins c-myc/analysis ; Transcription Factors/analysis ; Transcription Factors/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
Sub-centrosomal mapping identifies augmin-γTuRC as part of a centriole-stabilizing scaffold.
Autorzy :
Schweizer N; Mechanisms of Disease Programme, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028, Barcelona, Spain.
Haren L; Molecular, Cellular and Developmental Biology, Centre de Biologie Intégrative, CNRS-Université Toulouse III, 31062, Toulouse, France.
Dutto I; Mechanisms of Disease Programme, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028, Barcelona, Spain.
Viais R; Mechanisms of Disease Programme, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028, Barcelona, Spain.
Lacasa C; Mechanisms of Disease Programme, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028, Barcelona, Spain.
Merdes A; Molecular, Cellular and Developmental Biology, Centre de Biologie Intégrative, CNRS-Université Toulouse III, 31062, Toulouse, France.
Lüders J; Mechanisms of Disease Programme, Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), 08028, Barcelona, Spain. .
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Źródło :
Nature communications [Nat Commun] 2021 Oct 15; Vol. 12 (1), pp. 6042. Date of Electronic Publication: 2021 Oct 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Cycle Proteins/*isolation & purification
Cell Cycle Proteins/*metabolism
Centrioles/*metabolism
Microtubule-Associated Proteins/*isolation & purification
Microtubule-Associated Proteins/*metabolism
Microtubule-Organizing Center/*metabolism
Animals ; Carrier Proteins/metabolism ; Cell Cycle Proteins/ultrastructure ; Cell Line ; Centrioles/ultrastructure ; Centrosome/metabolism ; Centrosome/ultrastructure ; Cilia ; Female ; Humans ; Male ; Mice ; Microtubule-Associated Proteins/ultrastructure ; Microtubule-Organizing Center/ultrastructure ; Microtubules/metabolism ; Neurons
Czasopismo naukowe
Tytuł :
Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly.
Autorzy :
Cereghetti G; Institute of Biochemistry, Department of Biology, ETH Zurich, Zurich, Switzerland.; PhD Program for Molecular Life Sciences, Life Science Zurich, Zurich, Switzerland.
Wilson-Zbinden C; Institute of Biochemistry, Department of Biology, ETH Zurich, Zurich, Switzerland.
Kissling VM; Institute of Biochemistry, Department of Biology, ETH Zurich, Zurich, Switzerland.; PhD Program for Biomolecular Structure and Mechanism, Life Science Zurich, Zurich, Switzerland.
Diether M; Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.
Arm A; Institute of Biochemistry, Department of Biology, ETH Zurich, Zurich, Switzerland.
Yoo H; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.
Piazza I; Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.; Max Delbrück Center for Molecular Medicine, Berlin, Germany.
Saad S; Institute of Biochemistry, Department of Biology, ETH Zurich, Zurich, Switzerland.; Department of Chemical and Systems Biology, Stanford University, Stanford, CA, USA.
Picotti P; Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.
Drummond DA; Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.
Sauer U; Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland.
Dechant R; Institute of Biochemistry, Department of Biology, ETH Zurich, Zurich, Switzerland.
Peter M; Institute of Biochemistry, Department of Biology, ETH Zurich, Zurich, Switzerland. .
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Źródło :
Nature cell biology [Nat Cell Biol] 2021 Oct; Vol. 23 (10), pp. 1085-1094. Date of Electronic Publication: 2021 Oct 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Stress, Physiological*
Amyloid/*chemistry
Cell Cycle Proteins/*chemistry
Cytoplasmic Granules/*chemistry
Pyruvate Kinase/*metabolism
Saccharomyces cerevisiae/*metabolism
Saccharomyces cerevisiae Proteins/*metabolism
Adenosine Triphosphate/metabolism ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Fructosediphosphates/metabolism ; HSP70 Heat-Shock Proteins/genetics ; HSP70 Heat-Shock Proteins/metabolism ; Heat-Shock Proteins/genetics ; Heat-Shock Proteins/metabolism ; Pyruvate Kinase/chemistry ; Pyruvate Kinase/genetics ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/growth & development ; Saccharomyces cerevisiae Proteins/chemistry ; Saccharomyces cerevisiae Proteins/genetics
Czasopismo naukowe
Tytuł :
Wee1 Kinase: A Potential Target to Overcome Tumor Resistance to Therapy.
Autorzy :
Esposito F; IOM Ricerca srl, Viagrande, I-95029 Catania, Italy.
Giuffrida R; IOM Ricerca srl, Viagrande, I-95029 Catania, Italy.
Raciti G; IOM Ricerca srl, Viagrande, I-95029 Catania, Italy.
Puglisi C; IOM Ricerca srl, Viagrande, I-95029 Catania, Italy.
Forte S; IOM Ricerca srl, Viagrande, I-95029 Catania, Italy.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Oct 01; Vol. 22 (19). Date of Electronic Publication: 2021 Oct 01.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Biomarkers, Tumor*
Cell Cycle Proteins/*genetics
Drug Resistance, Neoplasm/*genetics
Protein-Tyrosine Kinases/*genetics
Radiation Tolerance/*genetics
Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Cell Cycle/drug effects ; Cell Cycle/genetics ; Cell Cycle Proteins/antagonists & inhibitors ; Cell Cycle Proteins/metabolism ; Combined Modality Therapy ; DNA Damage/drug effects ; DNA Damage/radiation effects ; Disease Progression ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Molecular Targeted Therapy ; Multigene Family ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/metabolism ; Organ Specificity/genetics ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Protein-Tyrosine Kinases/antagonists & inhibitors ; Protein-Tyrosine Kinases/metabolism
Czasopismo naukowe
Tytuł :
Cohesin Core Complex Gene Dosage Contributes to Germinal Center Derived Lymphoma Phenotypes and Outcomes.
Autorzy :
Rivas MA; Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, United States.
Durmaz C; Graduate Program on Physiology, Biophysics & Systems Biology, Weill Cornell Medicine, New York, NY, United States.
Kloetgen A; Department of Computational Biology of Infection Research, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Chin CR; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, United States.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Al-Saud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, United States.
Chen Z; Division of Biostatistics and Epidemiology, Department of Population Health Sciences, Weill Cornell Medical College, New York, NY, United States.
Bhinder B; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, United States.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Al-Saud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, United States.; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, United States.
Koren A; Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, United States.
Viny AD; Division of Hematology/Oncology, Department of Medicine, Columbia University Irving Medical Center, New York, NY, United States.; Columbia Stem Cell Initiative, Department of Genetics & Development, Columbia University, New York, NY, United States.
Scharer CD; Department of Microbiology and Immunology, School of Medicine, Emory University, Atlanta, GA, United States.
Boss JM; Department of Microbiology and Immunology, School of Medicine, Emory University, Atlanta, GA, United States.
Elemento O; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, United States.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Al-Saud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, United States.; Caryl and Israel Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, United States.
Mason CE; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, United States.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Al-Saud Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, United States.; The WorldQuant Initiative for Quantitative Prediction, Weill Cornell Medicine, New York, NY, United States.; The Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, United States.
Melnick AM; Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY, United States.
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Źródło :
Frontiers in immunology [Front Immunol] 2021 Sep 21; Vol. 12, pp. 688493. Date of Electronic Publication: 2021 Sep 21 (Print Publication: 2021).
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Gene Dosage*
Haploinsufficiency*
B-Lymphocytes/*immunology
Biomarkers, Tumor/*genetics
Cell Cycle Proteins/*genetics
Chondroitin Sulfate Proteoglycans/*genetics
Chromosomal Proteins, Non-Histone/*genetics
Germinal Center/*immunology
Lymphoma, Large B-Cell, Diffuse/*genetics
Plasma Cells/*immunology
Animals ; B-Lymphocytes/metabolism ; Biomarkers, Tumor/metabolism ; Cell Cycle Proteins/immunology ; Cell Cycle Proteins/metabolism ; Cell Differentiation ; Cells, Cultured ; Chondroitin Sulfate Proteoglycans/immunology ; Chondroitin Sulfate Proteoglycans/metabolism ; Chromosomal Proteins, Non-Histone/immunology ; Chromosomal Proteins, Non-Histone/metabolism ; Coculture Techniques ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Databases, Genetic ; Dioxygenases/genetics ; Dioxygenases/metabolism ; Gene Expression Regulation, Neoplastic ; Genetic Predisposition to Disease ; Germinal Center/metabolism ; Histone-Lysine N-Methyltransferase/genetics ; Histone-Lysine N-Methyltransferase/metabolism ; Humans ; Lymphoma, Large B-Cell, Diffuse/immunology ; Lymphoma, Large B-Cell, Diffuse/metabolism ; Mice, Knockout ; Myeloid-Lymphoid Leukemia Protein/genetics ; Myeloid-Lymphoid Leukemia Protein/metabolism ; Phenotype ; Plasma Cells/metabolism ; Transcription, Genetic
Czasopismo naukowe
Tytuł :
Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition.
Autorzy :
Yosaatmadja Y; Centre for Medicines Discovery, University of Oxford, ORCRB, Roosevelt Drive, Oxford OX3 7DQ, UK.
Baddock HT; Department of Oncology, MRC-Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.
Newman JA; Centre for Medicines Discovery, University of Oxford, ORCRB, Roosevelt Drive, Oxford OX3 7DQ, UK.
Bielinski M; The Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.
Gavard AE; Centre for Medicines Discovery, University of Oxford, ORCRB, Roosevelt Drive, Oxford OX3 7DQ, UK.
Mukhopadhyay SMM; Centre for Medicines Discovery, University of Oxford, ORCRB, Roosevelt Drive, Oxford OX3 7DQ, UK.
Dannerfjord AA; Centre for Medicines Discovery, University of Oxford, ORCRB, Roosevelt Drive, Oxford OX3 7DQ, UK.
Schofield CJ; The Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.
McHugh PJ; Department of Oncology, MRC-Weatherall Institute of Molecular Medicine, University of Oxford, Oxford OX3 9DS, UK.
Gileadi O; Centre for Medicines Discovery, University of Oxford, ORCRB, Roosevelt Drive, Oxford OX3 7DQ, UK.
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Źródło :
Nucleic acids research [Nucleic Acids Res] 2021 Sep 20; Vol. 49 (16), pp. 9310-9326.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Cycle Proteins/*ultrastructure
DNA-Binding Proteins/*ultrastructure
Endonucleases/*ultrastructure
Exodeoxyribonucleases/*ultrastructure
Severe Combined Immunodeficiency/*genetics
B-Lymphocytes/enzymology ; Catalytic Domain/genetics ; Cell Cycle Proteins/chemistry ; Cell Cycle Proteins/genetics ; Crystallography, X-Ray ; DNA End-Joining Repair/genetics ; DNA Repair/genetics ; DNA-Binding Proteins/antagonists & inhibitors ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/genetics ; Endonucleases/antagonists & inhibitors ; Endonucleases/chemistry ; Endonucleases/genetics ; Enzyme Inhibitors/chemistry ; Exodeoxyribonucleases/chemistry ; Exodeoxyribonucleases/genetics ; Humans ; Phosphorylation/genetics ; Protein Folding ; Severe Combined Immunodeficiency/enzymology ; Severe Combined Immunodeficiency/pathology ; T-Lymphocytes/enzymology
SCR Disease Name :
Severe combined immunodeficiency with sensitivity to ionizing radiation
Czasopismo naukowe
Tytuł :
SUV39 SET domains mediate crosstalk of heterochromatic histone marks.
Autorzy :
Stirpe A; Department of Molecular Biology, Faculty of Science, University of Geneva, Geneva, Switzerland.
Guidotti N; Institute of Chemical Sciences and Engineering (ISIC), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Northall SJ; Leicester Institute for Structural and Chemical Biology, University of Leicester, Leicester, United Kingdom.; Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom.
Kilic S; Institute of Chemical Sciences and Engineering (ISIC), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Hainard A; University Medical Center, University of Geneva, Geneva, Switzerland.
Vadas O; School of Pharmaceutical Sciences, Faculty of Science, University of Geneva, Geneva, Switzerland.
Fierz B; Institute of Chemical Sciences and Engineering (ISIC), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Schalch T; Department of Molecular Biology, Faculty of Science, University of Geneva, Geneva, Switzerland.; Leicester Institute for Structural and Chemical Biology, University of Leicester, Leicester, United Kingdom.; Department of Molecular and Cell Biology, University of Leicester, Leicester, United Kingdom.
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Źródło :
ELife [Elife] 2021 Sep 15; Vol. 10. Date of Electronic Publication: 2021 Sep 15.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Cycle Proteins*/genetics
Cell Cycle Proteins*/metabolism
Heterochromatin*/chemistry
Heterochromatin*/genetics
Heterochromatin*/metabolism
Histone-Lysine N-Methyltransferase*/genetics
Histone-Lysine N-Methyltransferase*/metabolism
Histones*/chemistry
Histones*/genetics
Histones*/metabolism
Schizosaccharomyces pombe Proteins*/genetics
Schizosaccharomyces pombe Proteins*/metabolism
Histone Code/*genetics
Catalytic Domain/genetics ; DNA Methylation/genetics ; Lysine/metabolism ; Ubiquitination/genetics
Czasopismo naukowe
Tytuł :
MAD2L2 dimerization and TRIP13 control shieldin activity in DNA repair.
Autorzy :
de Krijger I; Division of Oncogenomics, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Föhr B; Laboratory of Signal Dynamics, Max-Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Pérez SH; Division of Oncogenomics, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Vincendeau E; Genome Integrity, Immunity and Cancer Unit, Equipe Labellisée Ligue Contre Le Cancer, INSERM U1223, Institut Pasteur, Paris, France.; Université de Paris, Sorbonne Paris Cité, Paris, France.
Serrat J; Division of Oncogenomics, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Thouin AM; Division of Oncogenomics, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Susvirkar V; Laboratory of Signal Dynamics, Max-Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Lescale C; Genome Integrity, Immunity and Cancer Unit, Equipe Labellisée Ligue Contre Le Cancer, INSERM U1223, Institut Pasteur, Paris, France.
Paniagua I; Division of Oncogenomics, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Hoekman L; Proteomics Facility, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Kaur S; Laboratory of Signal Dynamics, Max-Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Altelaar M; Proteomics Facility, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Biomolecular Mass Spectrometry and Proteomics, Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, The Netherlands.
Deriano L; Genome Integrity, Immunity and Cancer Unit, Equipe Labellisée Ligue Contre Le Cancer, INSERM U1223, Institut Pasteur, Paris, France.
Faesen AC; Laboratory of Signal Dynamics, Max-Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Jacobs JJL; Division of Oncogenomics, The Netherlands Cancer Institute, Amsterdam, The Netherlands. .
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Źródło :
Nature communications [Nat Commun] 2021 Sep 14; Vol. 12 (1), pp. 5421. Date of Electronic Publication: 2021 Sep 14.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Repair*
ATPases Associated with Diverse Cellular Activities/*genetics
Cell Cycle Proteins/*genetics
DNA/*genetics
DNA-Binding Proteins/*genetics
Mad2 Proteins/*genetics
ATPases Associated with Diverse Cellular Activities/chemistry ; ATPases Associated with Diverse Cellular Activities/metabolism ; Animals ; Binding Sites ; Cell Cycle Proteins/chemistry ; Cell Cycle Proteins/metabolism ; Cell Line ; Cell Line, Tumor ; Cisplatin/pharmacology ; DNA/chemistry ; DNA/metabolism ; DNA Breaks, Double-Stranded ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/metabolism ; Fibroblasts/cytology ; Fibroblasts/drug effects ; Fibroblasts/metabolism ; Gene Expression ; HEK293 Cells ; HeLa Cells ; Humans ; Mad2 Proteins/chemistry ; Mad2 Proteins/metabolism ; Mice ; Phthalazines/pharmacology ; Piperazines/pharmacology ; Protein Binding ; Protein Interaction Domains and Motifs ; Protein Multimerization ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism
Czasopismo naukowe
Tytuł :
CDC20 promotes bone formation via APC/C dependent ubiquitination and degradation of p65.
Autorzy :
Du Y; Department of Prosthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, National Clinical Research Center for Oral Diseases, Beijing Key Laboratory of Digital Stomatology, Beijing, China.
Zhang M; Department of Prosthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, National Clinical Research Center for Oral Diseases, Beijing Key Laboratory of Digital Stomatology, Beijing, China.
Liu X; Department of Prosthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, National Clinical Research Center for Oral Diseases, Beijing Key Laboratory of Digital Stomatology, Beijing, China.
Li Z; Department of Prosthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, National Clinical Research Center for Oral Diseases, Beijing Key Laboratory of Digital Stomatology, Beijing, China.
Hu M; Department of Prosthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, National Clinical Research Center for Oral Diseases, Beijing Key Laboratory of Digital Stomatology, Beijing, China.
Tian Y; Department of Prosthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, National Clinical Research Center for Oral Diseases, Beijing Key Laboratory of Digital Stomatology, Beijing, China.
Lv L; Department of Prosthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, National Clinical Research Center for Oral Diseases, Beijing Key Laboratory of Digital Stomatology, Beijing, China.
Zhang X; Department of Prosthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, National Clinical Research Center for Oral Diseases, Beijing Key Laboratory of Digital Stomatology, Beijing, China.
Liu Y; Department of Prosthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, National Clinical Research Center for Oral Diseases, Beijing Key Laboratory of Digital Stomatology, Beijing, China.
Zhang P; Department of Prosthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, National Clinical Research Center for Oral Diseases, Beijing Key Laboratory of Digital Stomatology, Beijing, China.
Zhou Y; Department of Prosthodontics, Peking University School and Hospital of Stomatology, National Engineering Laboratory for Digital and Material Technology of Stomatology, National Clinical Research Center for Oral Diseases, Beijing Key Laboratory of Digital Stomatology, Beijing, China.
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Źródło :
EMBO reports [EMBO Rep] 2021 Sep 06; Vol. 22 (9), pp. e52576. Date of Electronic Publication: 2021 Aug 12.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Cycle Proteins*/genetics
Cell Cycle Proteins*/metabolism
Osteogenesis*/genetics
Anaphase-Promoting Complex-Cyclosome/genetics ; Anaphase-Promoting Complex-Cyclosome/metabolism ; Animals ; Cdc20 Proteins/genetics ; Cdc20 Proteins/metabolism ; Mice ; Ubiquitination
Czasopismo naukowe
Tytuł :
Antitumor effect of WEE1 blockade as monotherapy or in combination with cisplatin in urothelial cancer.
Autorzy :
Murakami K; Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Kita Y; Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Sakatani T; Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Hamada A; Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Mizuno K; Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Nakamura K; Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Takada H; Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Matsumoto K; Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Sano T; Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Goto T; Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Akamatsu S; Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Saito R; Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Tsuruyama T; Department of Diagnostic Pathology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Ogawa O; Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Kobayashi T; Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
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Źródło :
Cancer science [Cancer Sci] 2021 Sep; Vol. 112 (9), pp. 3669-3681. Date of Electronic Publication: 2021 Jul 29.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*administration & dosage
Cell Cycle Proteins/*antagonists & inhibitors
Cisplatin/*administration & dosage
Enzyme Inhibitors/*administration & dosage
Protein-Tyrosine Kinases/*antagonists & inhibitors
Pyrazoles/*administration & dosage
Pyrimidinones/*administration & dosage
Urinary Bladder Neoplasms/*drug therapy
Aged ; Aged, 80 and over ; Animals ; Apoptosis/drug effects ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Drug Synergism ; Drug Therapy, Combination ; Female ; Gene Knockdown Techniques ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Mice, SCID ; Mitosis/drug effects ; Protein-Tyrosine Kinases/genetics ; Protein-Tyrosine Kinases/metabolism ; Transfection ; Treatment Outcome ; Tumor Suppressor Protein p53/deficiency ; Tumor Suppressor Protein p53/genetics ; Urinary Bladder Neoplasms/metabolism ; Urinary Bladder Neoplasms/pathology ; Xenograft Model Antitumor Assays
Czasopismo naukowe
Tytuł :
Differential regulation of single microtubules and bundles by a three-protein module.
Autorzy :
Mani N; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Jiang S; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Neary AE; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.
Wijeratne SS; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.
Subramanian R; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA. .; Department of Genetics, Harvard Medical School, Boston, MA, USA. .
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Źródło :
Nature chemical biology [Nat Chem Biol] 2021 Sep; Vol. 17 (9), pp. 964-974. Date of Electronic Publication: 2021 Jun 03.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Cycle Proteins/*metabolism
Kinesin/*metabolism
Microtubule-Associated Proteins/*metabolism
Microtubules/*metabolism
Cell Cycle Proteins/genetics ; Cell Cycle Proteins/isolation & purification ; Humans ; Kinesin/genetics ; Kinesin/isolation & purification ; Microtubule-Associated Proteins/genetics ; Microtubule-Associated Proteins/isolation & purification
Czasopismo naukowe
Tytuł :
Silencing lncRNA-DGCR5 increased trophoblast cell migration, invasion and tube formation, and inhibited cell apoptosis via targeting miR-454-3p/GADD45A axis.
Autorzy :
Yang Y; Department of Obstetrics and Gynecology, Shanxi Bethune Hospital Shanxi Academy of Medical Sciences, No.99, Longcheng Street, Taiyuan, 030032, China. .
Shang H; Department of Obstetrics and Gynecology, Shanxi Bethune Hospital Shanxi Academy of Medical Sciences, No.99, Longcheng Street, Taiyuan, 030032, China.
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Źródło :
Molecular and cellular biochemistry [Mol Cell Biochem] 2021 Sep; Vol. 476 (9), pp. 3407-3421. Date of Electronic Publication: 2021 May 10.
Typ publikacji :
Journal Article
MeSH Terms :
Gene Expression Regulation*
Gene Silencing*
Cell Cycle Proteins/*antagonists & inhibitors
MicroRNAs/*antagonists & inhibitors
Pre-Eclampsia/*pathology
RNA, Long Noncoding/*antagonists & inhibitors
Trophoblasts/*pathology
Apoptosis ; Biomarkers/metabolism ; Case-Control Studies ; Cell Cycle ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Cell Movement ; Cell Proliferation ; Female ; Humans ; MicroRNAs/genetics ; Pre-Eclampsia/genetics ; Pre-Eclampsia/metabolism ; Pregnancy ; Prognosis ; RNA, Long Noncoding/genetics ; Survival Rate ; Trophoblasts/metabolism ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Propofol Represses Cell Growth and Metastasis by Modulating the Circular RNA Non-SMC Condensin I Complex Subunit G/MicroRNA-200a-3p/RAB5A Axis in Glioma.
Autorzy :
Zhang L; Department of Anesthesiology, The First Hospital of Hebei Medicine University, Shijiazhuang, China.
Chen H; Department of Anesthesiology, The First Hospital of Hebei Medicine University, Shijiazhuang, China.
Tian C; Department of Anesthesiology, The First Hospital of Hebei Medicine University, Shijiazhuang, China. Electronic address: .
Zheng D; Department of Anesthesiology, The First Hospital of Hebei Medicine University, Shijiazhuang, China.
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Źródło :
World neurosurgery [World Neurosurg] 2021 Sep; Vol. 153, pp. e46-e58. Date of Electronic Publication: 2021 Jun 12.
Typ publikacji :
Journal Article
MeSH Terms :
Anesthetics, Intravenous/*pharmacology
Brain Neoplasms/*genetics
Cell Cycle Proteins/*drug effects
Glioma/*genetics
MicroRNAs/*drug effects
Propofol/*pharmacology
rab5 GTP-Binding Proteins/*drug effects
Adult ; Apoptosis/drug effects ; Apoptosis/genetics ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Cell Movement/drug effects ; Cell Movement/genetics ; Cell Proliferation/drug effects ; Cell Proliferation/genetics ; Cell Survival/drug effects ; Cell Survival/genetics ; Female ; Glioma/metabolism ; Glioma/pathology ; Humans ; Male ; Matrix Metalloproteinase 2/drug effects ; Matrix Metalloproteinase 2/metabolism ; Matrix Metalloproteinase 9/drug effects ; Matrix Metalloproteinase 9/metabolism ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Transplantation ; RNA, Circular ; Real-Time Polymerase Chain Reaction ; Tumor Stem Cell Assay ; rab5 GTP-Binding Proteins/genetics ; rab5 GTP-Binding Proteins/metabolism
Czasopismo naukowe
Tytuł :
Development of photocontrolled BRD4 PROTACs for tongue squamous cell carcinoma (TSCC).
Autorzy :
Li Z; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.
Ma S; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.
Yang X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.
Zhang L; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.
Liang D; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.
Dong G; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.
Du L; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China. Electronic address: .
Lv Z; Department of Head and Neck Surgery, Shandong Provincial ENT Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250022, China. Electronic address: .
Li M; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Oct 15; Vol. 222, pp. 113608. Date of Electronic Publication: 2021 Jun 05.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Development*
Antineoplastic Agents/*pharmacology
Carcinoma, Squamous Cell/*drug therapy
Cell Cycle Proteins/*antagonists & inhibitors
Small Molecule Libraries/*pharmacology
Tongue Neoplasms/*drug therapy
Transcription Factors/*antagonists & inhibitors
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Carcinoma, Squamous Cell/metabolism ; Carcinoma, Squamous Cell/pathology ; Cell Cycle Proteins/metabolism ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cells, Cultured ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Mice ; Mice, Nude ; Molecular Structure ; Neoplasms, Experimental/drug therapy ; Neoplasms, Experimental/metabolism ; Neoplasms, Experimental/pathology ; Photochemical Processes ; Proteolysis ; Small Molecule Libraries/chemical synthesis ; Small Molecule Libraries/chemistry ; Structure-Activity Relationship ; Tongue Neoplasms/metabolism ; Tongue Neoplasms/pathology ; Transcription Factors/metabolism ; Zebrafish
Czasopismo naukowe
Tytuł :
Spatiotemporal coordination of the RSF1-PLK1-Aurora B cascade establishes mitotic signaling platforms.
Autorzy :
Lee HS; Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon, 16499, Korea. .
Min S; Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon, 16499, Korea.
Jung YE; Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, 03760, Republic of Korea.
Chae S; Institute of Medical Science, Ajou University School of Medicine, Suwon, 16499, Korea.
Heo J; Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon, 16499, Korea.; Department of Biomedical Sciences, Graduate School of Ajou University, Suwon, 16499, Korea.
Lee JH; Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon, 16499, Korea.; Institute of Medical Science, Ajou University School of Medicine, Suwon, 16499, Korea.
Kim T; Department of Life Science, Ewha Womans University, Seoul, 03760, Korea.
Kang HC; Department of Physiology, Ajou University School of Medicine, Suwon, Korea.
Nakanish M; Division of Cancer Cell Biology, The University of Tokyo, Tokyo, 108-8639, Japan.
Cha SS; Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, 03760, Republic of Korea.
Cho H; Department of Biochemistry and Molecular Biology, Ajou University School of Medicine, Suwon, 16499, Korea. .
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Źródło :
Nature communications [Nat Commun] 2021 Oct 11; Vol. 12 (1), pp. 5931. Date of Electronic Publication: 2021 Oct 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Chromosome Segregation*
Mitosis*
Aurora Kinase B/*genetics
Cell Cycle Proteins/*genetics
Nuclear Proteins/*genetics
Protein-Serine-Threonine Kinases/*genetics
Proto-Oncogene Proteins/*genetics
Signal Transduction/*genetics
Trans-Activators/*genetics
Aspartic Acid/metabolism ; Aurora Kinase B/metabolism ; Cell Cycle Proteins/metabolism ; Chromatin/chemistry ; Chromatin/metabolism ; Feedback, Physiological ; Gene Expression Regulation ; HeLa Cells ; Histones/genetics ; Histones/metabolism ; Humans ; Kinetochores/metabolism ; Kinetochores/ultrastructure ; Microtubules/metabolism ; Microtubules/ultrastructure ; Nuclear Proteins/deficiency ; Phosphorylation ; Protein-Serine-Threonine Kinases/metabolism ; Proto-Oncogene Proteins/metabolism ; Serine/metabolism ; Trans-Activators/deficiency
Czasopismo naukowe
Tytuł :
CircCDC45 promotes the malignant progression of glioblastoma by modulating the miR-485-5p/CSF-1 axis.
Autorzy :
Liu R; Department of Neurosurgery, Quzhou People's Hospital, No. 2, Zhongloudi, Kecheng District, Quzhou, 324000, Zhejiang, China.
Dai W; Department of Neurosurgery, Quzhou People's Hospital, No. 2, Zhongloudi, Kecheng District, Quzhou, 324000, Zhejiang, China. .
Wu A; Department of Neurosurgery, Quzhou People's Hospital, No. 2, Zhongloudi, Kecheng District, Quzhou, 324000, Zhejiang, China.
Li Y; Department of Neurosurgery, Quzhou People's Hospital, No. 2, Zhongloudi, Kecheng District, Quzhou, 324000, Zhejiang, China.
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Źródło :
BMC cancer [BMC Cancer] 2021 Oct 09; Vol. 21 (1), pp. 1090. Date of Electronic Publication: 2021 Oct 09.
Typ publikacji :
Journal Article
MeSH Terms :
Brain Neoplasms/*metabolism
Cell Cycle Proteins/*physiology
Glioblastoma/*metabolism
Macrophage Colony-Stimulating Factor/*metabolism
MicroRNAs/*metabolism
RNA, Circular/*metabolism
Animals ; Brain Neoplasms/pathology ; Cell Count/methods ; Cell Cycle Proteins/metabolism ; Cell Line, Tumor ; Cell Movement ; Cell Proliferation ; Disease Progression ; Down-Regulation ; Gene Silencing ; Glioblastoma/pathology ; Humans ; Luciferases/metabolism ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; MicroRNAs/genetics ; Models, Animal ; Neoplasm Invasiveness ; RNA, Messenger/metabolism ; Random Allocation ; Tumor Stem Cell Assay
Czasopismo naukowe
Tytuł :
DDK/Hsk1 phosphorylates and targets fission yeast histone deacetylase Hst4 for degradation to stabilize stalled DNA replication forks.
Autorzy :
Aricthota S; Laboratory of Chromatin Biology and Epigenetics, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India.; Graduate Studies, Manipal Academy of Higher Education, Manipal, India.
Haldar D; Laboratory of Chromatin Biology and Epigenetics, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India.
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Źródło :
ELife [Elife] 2021 Oct 05; Vol. 10. Date of Electronic Publication: 2021 Oct 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Cycle Proteins/*genetics
Histone Deacetylases/*genetics
Protein-Serine-Threonine Kinases/*genetics
Saccharomyces cerevisiae Proteins/*genetics
Schizosaccharomyces/*genetics
Schizosaccharomyces pombe Proteins/*genetics
Cell Cycle Proteins/metabolism ; DNA Replication ; Histone Deacetylases/metabolism ; Protein-Serine-Threonine Kinases/metabolism ; Saccharomyces cerevisiae Proteins/metabolism ; Schizosaccharomyces/metabolism ; Schizosaccharomyces pombe Proteins/metabolism
Czasopismo naukowe
Tytuł :
Loss of BubR1 acetylation provokes replication stress and leads to complex chromosomal rearrangements.
Autorzy :
Park J; Department of Biological Sciences & Institute of Molecular Biology and Genetics, Seoul National University, Korea.
Yeu SY; Department of Biological Sciences & Institute of Molecular Biology and Genetics, Seoul National University, Korea.
Paik S; Department of Biological Sciences & Institute of Molecular Biology and Genetics, Seoul National University, Korea.
Kim H; Department of Biological Sciences & Institute of Molecular Biology and Genetics, Seoul National University, Korea.
Choi SY; Department of Biological Sciences & Institute of Molecular Biology and Genetics, Seoul National University, Korea.
Lee J; Department of Biological Sciences & Institute of Molecular Biology and Genetics, Seoul National University, Korea.
Jang J; Department of Bioengineering, School of Life Sciences, Ulsan National Institute of Science and Technology, Korea.
Lee S; Department of Bioengineering, School of Life Sciences, Ulsan National Institute of Science and Technology, Korea.
Koh Y; Department of Internal Medicine, Seoul National University Hospital, Korea.
Lee H; Department of Biological Sciences & Institute of Molecular Biology and Genetics, Seoul National University, Korea.
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Źródło :
The FEBS journal [FEBS J] 2021 Oct; Vol. 288 (20), pp. 5925-5942. Date of Electronic Publication: 2021 May 21.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Aneuploidy*
Chromosomal Instability*
Chromosome Segregation*
Carcinogenesis/*pathology
Cell Cycle Proteins/*physiology
Protein-Serine-Threonine Kinases/*physiology
Telomere/*genetics
Tumor Suppressor Protein p53/*physiology
Acetylation ; Animals ; Carcinogenesis/genetics ; Carcinogenesis/metabolism ; Cell Cycle Checkpoints ; Cell Cycle Proteins/chemistry ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Protein-Serine-Threonine Kinases/chemistry
Czasopismo naukowe
Tytuł :
Stable maintenance of the Mre11-Rad50-Nbs1 complex is sufficient to restore the DNA double-strand break response in cells lacking RecQL4 helicase activity.
Autorzy :
Kim H; Interdisciplinary Graduate Program in Genetic Engineering, Seoul National University, Seoul, Korea.
Choi H; Department of Biology Education, Seoul National University, Seoul, Korea.
Im JS; Department of Biology Education, Seoul National University, Seoul, Korea.
Park SY; Department of Biology Education, Seoul National University, Seoul, Korea.
Shin G; Interdisciplinary Graduate Program in Genetic Engineering, Seoul National University, Seoul, Korea.
Yoo JH; Department of Biology Education, Seoul National University, Seoul, Korea.
Kim G; Department of Biology Education, Seoul National University, Seoul, Korea.
Lee JK; Interdisciplinary Graduate Program in Genetic Engineering, Seoul National University, Seoul, Korea; Department of Biology Education, Seoul National University, Seoul, Korea. Electronic address: .
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Źródło :
The Journal of biological chemistry [J Biol Chem] 2021 Oct; Vol. 297 (4), pp. 101148. Date of Electronic Publication: 2021 Aug 30.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
DNA Breaks, Double-Stranded*
DNA Repair*
Acid Anhydride Hydrolases/*metabolism
Cell Cycle Proteins/*metabolism
DNA-Binding Proteins/*metabolism
MRE11 Homologue Protein/*metabolism
Multiprotein Complexes/*metabolism
Nuclear Proteins/*metabolism
RecQ Helicases/*metabolism
Acid Anhydride Hydrolases/genetics ; Cell Cycle Proteins/genetics ; Cell Line, Tumor ; DNA-Binding Proteins/genetics ; HEK293 Cells ; Humans ; MRE11 Homologue Protein/genetics ; Multiprotein Complexes/genetics ; Nuclear Proteins/genetics ; RecQ Helicases/genetics
Czasopismo naukowe
Tytuł :
[The Relationship between HIF1α and WTAP Expression Level in t(8;21) Acute Myeloid Leukemia].
Autorzy :
Shao YL; Department of Hematology, First Medical Center, Chinese PLA General Hospital, Beijing 100853, China Medical School of Chinese PLA,Beijing 100853,China; Chinese PLA Unit 31647,Guigang 537100,Guangxi Zhuang Autonomous Region, China.
Chen Z; Department of Hematology, First Medical Center, Chinese PLA General Hospital, Beijing 100853, China Medical School of Chinese PLA,Beijing 100853,China.
Wang LL; Department of Hematology, First Medical Center, Chinese PLA General Hospital, Beijing 100853, China.
Liu DH; Department of Hematology, First Medical Center, Chinese PLA General Hospital, Beijing 100853, China.
Gao XN; Department of Hematology, First Medical Center, Chinese PLA General Hospital, Beijing 100853, China E-mail: .
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Źródło :
Zhongguo shi yan xue ye xue za zhi [Zhongguo Shi Yan Xue Ye Xue Za Zhi] 2021 Oct; Vol. 29 (5), pp. 1424-1428.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Cycle Proteins*
Leukemia, Myeloid, Acute*/genetics
Humans ; Hypoxia-Inducible Factor 1, alpha Subunit ; Nuclear Proteins ; RNA Splicing Factors ; RNA, Messenger
Czasopismo naukowe

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