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Tytuł :
Regulation of Neutrophil Functions by Hv1/VSOP Voltage-Gated Proton Channels.
Autorzy :
Okochi Y; Integrative Physiology, Graduate School of Medicine, Osaka University, 2-2 Yamada-oka, Suita 5650871, Osaka, Japan.
Okamura Y; Integrative Physiology, Graduate School of Medicine, Osaka University, 2-2 Yamada-oka, Suita 5650871, Osaka, Japan.; Graduate School of Frontier Bioscience, Osaka University, 2-2 Yamada-oka, Suita 5650871, Osaka, Japan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 05; Vol. 22 (5). Date of Electronic Publication: 2021 Mar 05.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Calcium Signaling*
Cell Degranulation*
MAP Kinase Signaling System*
Ion Channels/*metabolism
Neutrophils/*metabolism
Animals ; Bacteria/metabolism ; Humans ; Mice ; NADPH Oxidases/metabolism ; Neutrophils/microbiology ; Reactive Oxygen Species/metabolism
Czasopismo naukowe
Tytuł :
IFN signaling and neutrophil degranulation transcriptional signatures are induced during SARS-CoV-2 infection.
Autorzy :
Rosa BA; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Ahmed M; Department of Molecular Microbiology, Washington University in St. Louis, St. Louis, MO, USA.
Singh DK; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA.
Choreño-Parra JA; Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico.
Cole J; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA.
Jiménez-Álvarez LA; Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico.
Rodríguez-Reyna TS; Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Singh B; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA.
Gonzalez O; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA.
Carrion R Jr; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA.
Schlesinger LS; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA.
Martin J; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
Zúñiga J; Laboratory of Immunobiology and Genetics, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico.
Mitreva M; Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA. .
Kaushal D; Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA. .
Khader SA; Department of Molecular Microbiology, Washington University in St. Louis, St. Louis, MO, USA. .
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Źródło :
Communications biology [Commun Biol] 2021 Mar 05; Vol. 4 (1), pp. 290. Date of Electronic Publication: 2021 Mar 05.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Degranulation*
SARS-CoV-2*
COVID-19/*immunology
Interferons/*physiology
Neutrophils/*physiology
Aged ; Animals ; CD36 Antigens/physiology ; COVID-19/etiology ; Collagen/metabolism ; Disease Models, Animal ; Female ; Gene Expression Regulation ; Humans ; Lung/metabolism ; Macaca mulatta ; Male ; Middle Aged ; Receptors, Notch/physiology ; Signal Transduction/physiology ; Transforming Growth Factor beta/physiology ; Vascular Endothelial Growth Factor A/blood ; Vascular Endothelial Growth Factor A/physiology
Czasopismo naukowe
Tytuł :
Mast Cell Degranulation Increases Mouse Mast Cell Protease 4-Dependent Vasopressor Responses to Big Endothelin-1 But Not Angiotensin I.
Autorzy :
Vincent L; Department of Pharmacology and Physiology, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Quebec, Canada (L.V., C.L., M.L., P.D.-J.); PhenoSwitch Bioscience Inc., Sherbrooke, Quebec, Canada (H.G.); Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden (G.P.); Department of Innovative Medicine, Osaka Medical College, Osaka, Japan (S.T.); and Department of Surgery, Division of Urology, Université de Sherbrooke, Sherbrooke, Quebec, Canada (R.D.).
Lapointe C; Department of Pharmacology and Physiology, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Quebec, Canada (L.V., C.L., M.L., P.D.-J.); PhenoSwitch Bioscience Inc., Sherbrooke, Quebec, Canada (H.G.); Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden (G.P.); Department of Innovative Medicine, Osaka Medical College, Osaka, Japan (S.T.); and Department of Surgery, Division of Urology, Université de Sherbrooke, Sherbrooke, Quebec, Canada (R.D.).
Lo M; Department of Pharmacology and Physiology, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Quebec, Canada (L.V., C.L., M.L., P.D.-J.); PhenoSwitch Bioscience Inc., Sherbrooke, Quebec, Canada (H.G.); Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden (G.P.); Department of Innovative Medicine, Osaka Medical College, Osaka, Japan (S.T.); and Department of Surgery, Division of Urology, Université de Sherbrooke, Sherbrooke, Quebec, Canada (R.D.).
Gagnon H; Department of Pharmacology and Physiology, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Quebec, Canada (L.V., C.L., M.L., P.D.-J.); PhenoSwitch Bioscience Inc., Sherbrooke, Quebec, Canada (H.G.); Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden (G.P.); Department of Innovative Medicine, Osaka Medical College, Osaka, Japan (S.T.); and Department of Surgery, Division of Urology, Université de Sherbrooke, Sherbrooke, Quebec, Canada (R.D.).
Pejler G; Department of Pharmacology and Physiology, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Quebec, Canada (L.V., C.L., M.L., P.D.-J.); PhenoSwitch Bioscience Inc., Sherbrooke, Quebec, Canada (H.G.); Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden (G.P.); Department of Innovative Medicine, Osaka Medical College, Osaka, Japan (S.T.); and Department of Surgery, Division of Urology, Université de Sherbrooke, Sherbrooke, Quebec, Canada (R.D.).
Takai S; Department of Pharmacology and Physiology, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Quebec, Canada (L.V., C.L., M.L., P.D.-J.); PhenoSwitch Bioscience Inc., Sherbrooke, Quebec, Canada (H.G.); Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden (G.P.); Department of Innovative Medicine, Osaka Medical College, Osaka, Japan (S.T.); and Department of Surgery, Division of Urology, Université de Sherbrooke, Sherbrooke, Quebec, Canada (R.D.).
Day R; Department of Pharmacology and Physiology, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Quebec, Canada (L.V., C.L., M.L., P.D.-J.); PhenoSwitch Bioscience Inc., Sherbrooke, Quebec, Canada (H.G.); Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden (G.P.); Department of Innovative Medicine, Osaka Medical College, Osaka, Japan (S.T.); and Department of Surgery, Division of Urology, Université de Sherbrooke, Sherbrooke, Quebec, Canada (R.D.).
D'Orléans-Juste P; Department of Pharmacology and Physiology, Faculté de Médecine et des Sciences de la Santé, Université de Sherbrooke, Sherbrooke, Quebec, Canada (L.V., C.L., M.L., P.D.-J.); PhenoSwitch Bioscience Inc., Sherbrooke, Quebec, Canada (H.G.); Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden (G.P.); Department of Innovative Medicine, Osaka Medical College, Osaka, Japan (S.T.); and Department of Surgery, Division of Urology, Université de Sherbrooke, Sherbrooke, Quebec, Canada (R.D.) .
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Źródło :
The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2021 Feb; Vol. 376 (2), pp. 213-221. Date of Electronic Publication: 2020 Nov 05.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Blood Pressure*
Cell Degranulation*
Angiotensin I/*pharmacology
Endothelin-1/*pharmacology
Mast Cells/*physiology
Serine Endopeptidases/*metabolism
Animals ; Cells, Cultured ; Chymases/antagonists & inhibitors ; Cromolyn Sodium/pharmacology ; Enzyme Inhibitors/pharmacology ; Male ; Mast Cell Stabilizers/pharmacology ; Mast Cells/drug effects ; Mast Cells/metabolism ; Mice ; Mice, Inbred C57BL ; Peritoneum/cytology ; Serine Endopeptidases/genetics ; Sulfonamides/pharmacology ; Thiophenes/pharmacology
Czasopismo naukowe
Tytuł :
MRGPRX2 activation as a rapid, high-throughput mechanistic-based approach for detecting peptide-mediated human mast cell degranulation liabilities.
Autorzy :
Lafleur MA; Translational Safety & Bioanalytical Sciences, Amgen Research, Amgen Inc., Thousand Oaks, CA, USA.
Werner J; Translational Safety & Bioanalytical Sciences, Amgen Research, Amgen Inc., Thousand Oaks, CA, USA.
Fort M; Translational Safety & Bioanalytical Sciences, Amgen Research, Amgen Inc., Thousand Oaks, CA, USA.
Lobenhofer EK; Translational Safety & Bioanalytical Sciences, Amgen Research, Amgen Inc., Thousand Oaks, CA, USA.
Balazs M; Translational Safety & Bioanalytical Sciences, Amgen Research, Amgen, Inc., South San Francisco, CA, USA.
Goyos A; Translational Safety & Bioanalytical Sciences, Amgen Research, Amgen, Inc., South San Francisco, CA, USA.
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Źródło :
Journal of immunotoxicology [J Immunotoxicol] 2020 Dec; Vol. 17 (1), pp. 110-121.
Typ publikacji :
Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Degranulation/*drug effects
High-Throughput Screening Assays/*methods
Mast Cells/*drug effects
Nerve Tissue Proteins/*metabolism
Peptides/*adverse effects
Receptors, G-Protein-Coupled/*metabolism
Receptors, Neuropeptide/*metabolism
Antigens, CD34/metabolism ; Cell Degranulation/immunology ; Cell Engineering ; Cells, Cultured ; Cytotoxicity Tests, Immunologic/methods ; Drug Evaluation, Preclinical/methods ; Hematopoietic Stem Cell Mobilization ; Hematopoietic Stem Cells/metabolism ; Histamine/analysis ; Histamine/metabolism ; Humans ; Mast Cells/immunology ; Mast Cells/metabolism ; Primary Cell Culture ; Sensitivity and Specificity
Czasopismo naukowe
Tytuł :
Reliable Postmortem Molecular Diagnosis of Anaphylaxis: Co-localization of Mast Cell Degranulation and Immunoglobulin E in Allergic Throat Tissues.
Autorzy :
Wang X; From the Department of General Pathology, The First Affiliated Hospital, School of Medicine, Yangtze University, Jingzhou, Hubei Province.
Yin C; From the Department of General Pathology, The First Affiliated Hospital, School of Medicine, Yangtze University, Jingzhou, Hubei Province.
Su X; Institute of Clinical Pathology, Medical College of Shantou University, Shantou, Guangdong Province, China.
Su M; Institute of Clinical Pathology, Medical College of Shantou University, Shantou, Guangdong Province, China.
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Źródło :
The American journal of forensic medicine and pathology [Am J Forensic Med Pathol] 2020 Dec; Vol. 41 (4), pp. 249-258.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Degranulation*
Postmortem Changes*
Anaphylaxis/*pathology
Immunoglobulin E/*metabolism
Mast Cells/*pathology
Pharynx/*pathology
Adolescent ; Adult ; Aged ; Case-Control Studies ; Child ; Child, Preschool ; Female ; Humans ; Immunohistochemistry ; Infant ; Infant, Newborn ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/pathology ; Larynx/metabolism ; Larynx/pathology ; Lung/pathology ; Male ; Middle Aged ; Pharynx/metabolism ; Young Adult
Czasopismo naukowe
Tytuł :
Eucalyptus oil reduces allergic reactions and suppresses mast cell degranulation by downregulating IgE-FcεRI signalling.
Autorzy :
Nakamura T; Department of R&D Center, Ikeda Mohando Co., Ltd, 16 Jinden, Kamiichi, Nakaniikawa, Toyama, 930-0394, Japan. .
Yoshida N; Department of R&D Center, Ikeda Mohando Co., Ltd, 16 Jinden, Kamiichi, Nakaniikawa, Toyama, 930-0394, Japan.
Yamanoi Y; Department of R&D Center, Ikeda Mohando Co., Ltd, 16 Jinden, Kamiichi, Nakaniikawa, Toyama, 930-0394, Japan.
Honryo A; Department of R&D Center, Ikeda Mohando Co., Ltd, 16 Jinden, Kamiichi, Nakaniikawa, Toyama, 930-0394, Japan.
Tomita H; Department of R&D Center, Ikeda Mohando Co., Ltd, 16 Jinden, Kamiichi, Nakaniikawa, Toyama, 930-0394, Japan.
Kuwabara H; Department of R&D Center, Ikeda Mohando Co., Ltd, 16 Jinden, Kamiichi, Nakaniikawa, Toyama, 930-0394, Japan.
Kojima Y; Department of R&D Center, Ikeda Mohando Co., Ltd, 16 Jinden, Kamiichi, Nakaniikawa, Toyama, 930-0394, Japan.
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Źródło :
Scientific reports [Sci Rep] 2020 Dec 01; Vol. 10 (1), pp. 20940. Date of Electronic Publication: 2020 Dec 01.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Degranulation*/drug effects
Down-Regulation*/drug effects
Signal Transduction*/drug effects
Eucalyptus Oil/*therapeutic use
Hypersensitivity/*drug therapy
Immunoglobulin E/*metabolism
Mast Cells/*physiology
Receptors, IgE/*metabolism
Animals ; Bone Marrow Cells/drug effects ; Calcium/metabolism ; Chemokines/metabolism ; Disease Models, Animal ; Eucalyptol/pharmacology ; Inflammation/pathology ; Inflammation Mediators/metabolism ; Intracellular Space/metabolism ; Mast Cells/drug effects ; Mice ; Models, Biological ; Passive Cutaneous Anaphylaxis/drug effects ; Phospholipase C gamma/metabolism ; Phosphorylation ; Syk Kinase/metabolism ; p38 Mitogen-Activated Protein Kinases/metabolism ; src-Family Kinases
Czasopismo naukowe
Tytuł :
Epinephrine drives human M2a allergic macrophages to a regulatory phenotype reducing mast cell degranulation in vitro.
Autorzy :
Gotovina J; Comparative Medicine, The Interuniversity Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University of Vienna and University of Vienna, Vienna, Austria.; Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Bianchini R; Comparative Medicine, The Interuniversity Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University of Vienna and University of Vienna, Vienna, Austria.; Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Fazekas-Singer J; Comparative Medicine, The Interuniversity Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University of Vienna and University of Vienna, Vienna, Austria.; Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Herrmann I; Comparative Medicine, The Interuniversity Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University of Vienna and University of Vienna, Vienna, Austria.; Department for Companion Animals and Horses, Small Animal Clinic, Internal Medicine, University of Veterinary Medicine, Vienna, Austria.
Pellizzari G; St John's Institute of Dermatology, School of Basic and Medical Biosciences, Guy's Cancer Centre, King's College London, London, UK.
Haidl ID; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada.
Hufnagl K; Comparative Medicine, The Interuniversity Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University of Vienna and University of Vienna, Vienna, Austria.
Karagiannis SN; Breast Cancer Now Unit, School of Cancer and Pharmaceutical Sciences, Guy's Cancer Centre, King's College London, London, UK.
Marshall JS; Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada.
Jensen-Jarolim E; Comparative Medicine, The Interuniversity Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University of Vienna and University of Vienna, Vienna, Austria.; Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
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Źródło :
Allergy [Allergy] 2020 Nov; Vol. 75 (11), pp. 2939-2942. Date of Electronic Publication: 2020 Apr 17.
Typ publikacji :
Letter; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Degranulation*
Mast Cells*
Epinephrine ; Humans ; Macrophages ; Phenotype
Raport
Tytuł :
Functional role of phosphatidylcholine-specific phospholipase C in regulating leukotriene synthesis and degranulation in human eosinophils.
Autorzy :
Sano A; Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, 377-2, Ohnohigashi Osakasayama, Osaka, 589-8511, Japan. Electronic address: .
Sano H; Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, 377-2, Ohnohigashi Osakasayama, Osaka, 589-8511, Japan.
Iwanaga T; Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, 377-2, Ohnohigashi Osakasayama, Osaka, 589-8511, Japan.
Tohda Y; Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine, 377-2, Ohnohigashi Osakasayama, Osaka, 589-8511, Japan.
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Źródło :
European journal of pharmacology [Eur J Pharmacol] 2020 Oct 05; Vol. 884, pp. 173353. Date of Electronic Publication: 2020 Jul 22.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Degranulation*/drug effects
Eosinophils/*enzymology
Leukotrienes/*metabolism
Type C Phospholipases/*metabolism
Arachidonic Acid/metabolism ; Calcium Signaling ; Cytochalasin B/pharmacology ; Enzyme Activation ; Eosinophils/drug effects ; Group IV Phospholipases A2/metabolism ; Humans ; Leukotriene C4/metabolism ; N-Formylmethionine Leucyl-Phenylalanine/pharmacology ; Norbornanes/pharmacology ; Phosphodiesterase Inhibitors/pharmacology ; Signal Transduction ; Thiocarbamates/pharmacology ; Type C Phospholipases/antagonists & inhibitors
Czasopismo naukowe
Tytuł :
[Shikimic acid extracted from Chaenomeles speciosa reduces chondrocyte differentiation by inhibiting RBL-2H3 cell degranulation].
Autorzy :
Chen G; Three-Level Laboratory for Traditional Chinese Pharmacologic (Tumor) Research, Medical College, China Three Gorges University, Yichang 443002, China.
Zheng Q; Three-Level Laboratory for Traditional Chinese Pharmacologic (Tumor) Research, Medical College, China Three Gorges University, Yichang 443002, China.
Yu J; Three-Level Laboratory for Traditional Chinese Pharmacologic (Tumor) Research, Medical College, China Three Gorges University, Yichang 443002, China.
Yan M; Three-Level Laboratory for Traditional Chinese Pharmacologic (Tumor) Research, Medical College, China Three Gorges University, Yichang 443002, China.
Zhou T; Three-Level Laboratory for Traditional Chinese Pharmacologic (Tumor) Research, Medical College, China Three Gorges University, Yichang 443002, China.
Cao H; Three-Level Laboratory for Traditional Chinese Pharmacologic (Tumor) Research, Medical College, China Three Gorges University, Yichang 443002, China.
Li S; Three-Level Laboratory for Traditional Chinese Pharmacologic (Tumor) Research, Medical College, China Three Gorges University, Yichang 443002, China. *Corresponding author, E-mail: .
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Źródło :
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology [Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi] 2020 Oct; Vol. 36 (10), pp. 890-896.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Degranulation*
Cell Differentiation*
Chondrocytes/*drug effects
Mast Cells/*drug effects
Rosaceae/*chemistry
Shikimic Acid/*pharmacology
Animals ; Cell Line, Tumor ; Chondrocytes/cytology ; Mast Cells/cytology ; Rats
Czasopismo naukowe
Tytuł :
Substance P Serves as a Balanced Agonist for MRGPRX2 and a Single Tyrosine Residue Is Required for β-Arrestin Recruitment and Receptor Internalization.
Autorzy :
Chompunud Na Ayudhya C; Department of Basic and Translational Sciences, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Oral Diagnosis, Faculty of Dentistry, Naresuan University, Phitsanulok 65000, Thailand.
Amponnawarat A; Department of Basic and Translational Sciences, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.; Department of Family and Community Dentistry, Faculty of Dentistry, Chiang Mai University, Chiang Mai 50200, Thailand.
Ali H; Department of Basic and Translational Sciences, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 18; Vol. 22 (10). Date of Electronic Publication: 2021 May 18.
Typ publikacji :
Journal Article
MeSH Terms :
Nerve Tissue Proteins/*agonists
Receptors, G-Protein-Coupled/*agonists
Receptors, Neuropeptide/*agonists
Substance P/*metabolism
beta-Arrestins/*metabolism
Amino Acid Substitution ; Animals ; Cell Degranulation ; Cell Line ; Female ; Humans ; Male ; Mast Cells/physiology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mutagenesis, Site-Directed ; Nerve Tissue Proteins/chemistry ; Nerve Tissue Proteins/genetics ; Neuroimmunomodulation/physiology ; Rats ; Receptors, G-Protein-Coupled/chemistry ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism ; Receptors, Neuropeptide/chemistry ; Receptors, Neuropeptide/genetics ; Tyrosine/chemistry ; beta-Arrestin 2/deficiency ; beta-Arrestin 2/genetics ; beta-Arrestin 2/metabolism
Czasopismo naukowe
Tytuł :
Invited response to letter to the editor by Tustumi et al.
Autorzy :
Spechler SJ; Center for Esophageal Diseases, Baylor University Medical Center and Center for Esophageal Research, Baylor Scott & White Research Institute, Dallas, TX, USA.
Nelson M; Center for Esophageal Diseases, Baylor University Medical Center and Center for Esophageal Research, Baylor Scott & White Research Institute, Dallas, TX, USA.
Souza RF; Center for Esophageal Diseases, Baylor University Medical Center and Center for Esophageal Research, Baylor Scott & White Research Institute, Dallas, TX, USA.
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Źródło :
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society [Neurogastroenterol Motil] 2021 May; Vol. 33 (5), pp. e14114. Date of Electronic Publication: 2021 Feb 26.
Typ publikacji :
Letter; Comment
MeSH Terms :
Esophageal Achalasia*
Esophageal Sphincter, Lower*
Cell Degranulation ; Humans
Opinia redakcyjna
Tytuł :
Achalasia: A syndrome.
Autorzy :
Tustumi F; Universidade de São Paulo, São Paulo, Brazil.; Hospital Israelita Albert Einstein, São Paulo, Brazil.; Centro Universitário Lusíada, São Paulo, Brazil.
Tavares G; Centro Universitário Lusíada, São Paulo, Brazil.
Tristão LS; Centro Universitário Lusíada, São Paulo, Brazil.
Morrell ALG; Universidade de São Paulo, São Paulo, Brazil.; Hospital Israelita Albert Einstein, São Paulo, Brazil.; Instituto Morrell, São Paulo, Brazil.
Szor DJ; Universidade de São Paulo, São Paulo, Brazil.
Dias AR; Universidade de São Paulo, São Paulo, Brazil.
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Źródło :
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society [Neurogastroenterol Motil] 2021 May; Vol. 33 (5), pp. e14089. Date of Electronic Publication: 2021 Jan 27.
Typ publikacji :
Letter; Comment
MeSH Terms :
Esophageal Achalasia*/diagnosis
Cell Degranulation ; Esophageal Sphincter, Lower ; Humans ; Muscles ; Syndrome
Opinia redakcyjna
Tytuł :
Anti-Food Allergic Compounds from Penicillium griseofulvum MCCC 3A00225, a Deep-Sea-Derived Fungus.
Autorzy :
Xing CP; Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources,184 Daxue Road, Xiamen 361005, China.
Chen D; Fujian Universities and Colleges Engineering Research Center of Marine Biopharmaceutical Resources, Xiamen Medical College, 1999 Guankouzhong Road, Xiamen 361023, China.
Xie CL; Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources,184 Daxue Road, Xiamen 361005, China.
Liu Q; College of Food and Biological Engineering, Jimei University, 43 Yindou Road, Xiamen 361021, China.
Zhong TH; Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources,184 Daxue Road, Xiamen 361005, China.
Shao Z; Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources,184 Daxue Road, Xiamen 361005, China.
Liu G; College of Food and Biological Engineering, Jimei University, 43 Yindou Road, Xiamen 361021, China.
Luo LZ; Fujian Universities and Colleges Engineering Research Center of Marine Biopharmaceutical Resources, Xiamen Medical College, 1999 Guankouzhong Road, Xiamen 361023, China.
Yang XW; Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources,184 Daxue Road, Xiamen 361005, China.
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Źródło :
Marine drugs [Mar Drugs] 2021 Apr 16; Vol. 19 (4). Date of Electronic Publication: 2021 Apr 16.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Anti-Allergic Agents/*pharmacology
Basophils/*drug effects
Cell Degranulation/*drug effects
Food Hypersensitivity/*drug therapy
Penicillium/*metabolism
Animals ; Anti-Allergic Agents/isolation & purification ; Basophils/immunology ; Cell Line, Tumor ; Food Hypersensitivity/immunology ; Geologic Sediments/microbiology ; Immunoglobulin E/immunology ; Molecular Structure ; Rats ; Structure-Activity Relationship
SCR Organism :
Penicillium griseofulvum
Czasopismo naukowe
Tytuł :
Revisiting the Schistosoma japonicum life cycle transcriptome for new insights into lung schistosomula development.
Autorzy :
King M; School of Biological Sciences, Queen's University Belfast, Belfast, BT9 5DL, UK.
Carson J; School of Biological Sciences, Queen's University Belfast, Belfast, BT9 5DL, UK.
Stewart MT; School of Biological Sciences, Queen's University Belfast, Belfast, BT9 5DL, UK.
Gobert GN; School of Biological Sciences, Queen's University Belfast, Belfast, BT9 5DL, UK. Electronic address: .
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Źródło :
Experimental parasitology [Exp Parasitol] 2021 Apr; Vol. 223, pp. 108080. Date of Electronic Publication: 2021 Feb 04.
Typ publikacji :
Journal Article; Systematic Review
MeSH Terms :
Life Cycle Stages*
Lung/*parasitology
Lung Diseases, Parasitic/*parasitology
Schistosoma japonicum/*growth & development
Schistosomiasis japonica/*parasitology
Transcriptome/*physiology
Analysis of Variance ; Animals ; Cell Degranulation/physiology ; Datasets as Topic ; Glucose Transport Proteins, Facilitative/physiology ; Host-Parasite Interactions ; Lung Diseases, Parasitic/immunology ; Neutrophils/physiology ; Peptide Elongation Factor 1/physiology ; Schistosoma japonicum/genetics ; Schistosoma japonicum/immunology ; Schistosomiasis japonica/immunology
Czasopismo naukowe
Tytuł :
Histone H4 directly stimulates neutrophil activation through membrane permeabilization.
Autorzy :
Hsieh IN; Department of Medicine, Section of Hematology Oncology, Boston University School of Medicine, Boston, Massachusetts, USA.
Deluna X; Department of Medicine, Section of Hematology Oncology, Boston University School of Medicine, Boston, Massachusetts, USA.
White MR; Department of Medicine, Section of Hematology Oncology, Boston University School of Medicine, Boston, Massachusetts, USA.
Hartshorn KL; Department of Medicine, Section of Hematology Oncology, Boston University School of Medicine, Boston, Massachusetts, USA.
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Źródło :
Journal of leukocyte biology [J Leukoc Biol] 2021 Apr; Vol. 109 (4), pp. 763-775. Date of Electronic Publication: 2020 Aug 17.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural
MeSH Terms :
Cell Membrane Permeability*/drug effects
Neutrophil Activation*/drug effects
Histones/*metabolism
Calcium/metabolism ; Cell Adhesion/drug effects ; Cell Degranulation/drug effects ; Cell Membrane/drug effects ; Cell Membrane/metabolism ; Humans ; Hydrogen Peroxide/metabolism ; Integrins/metabolism ; Monocytes/drug effects ; Monocytes/metabolism ; Neutrophils/drug effects ; Neutrophils/metabolism ; Neutrophils/physiology ; Peroxidase/metabolism ; Pertussis Toxin/pharmacology ; Respiratory Burst/drug effects ; Signal Transduction/drug effects ; Wortmannin/pharmacology
Czasopismo naukowe
Tytuł :
A common signaling pathway leading to degranulation in mast cells and its regulation by CCR1-ligand.
Autorzy :
Chang HW; College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea.
Kanegasaki S; Research Institute National Center for Global Health and Medicine, Shinjuku-ku, Japan.; College of Medicine, Yeungnam University, Daegu, Republic of Korea.
Jin F; College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea.
Deng Y; College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea.
You Z; College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea.
Chang JH; College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea.
Kim DY; College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea.
Timilshina M; College of Pharmacy, Yeungnam University, Gyeongsan, Republic of Korea.
Kim JR; College of Medicine, Yeungnam University, Daegu, Republic of Korea.
Lee YJ; Department of Pharmacology, School of Medicine, Catholic University of Daegu, Daegu, Republic of Korea.
Toyama-Sorimachi N; Research Institute National Center for Global Health and Medicine, Shinjuku-ku, Japan.
Tsuchiya T; Research Institute National Center for Global Health and Medicine, Shinjuku-ku, Japan.; College of Medicine, Yeungnam University, Daegu, Republic of Korea.
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Źródło :
Allergy [Allergy] 2020 Jun; Vol. 75 (6), pp. 1371-1381. Date of Electronic Publication: 2020 Feb 06.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Degranulation*
Mast Cells*/metabolism
Animals ; Ligands ; Mice ; Phosphorylation ; Receptors, CCR1 ; Receptors, IgE/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Attenuation of allergen-mediated mast cell activation by rosemary extract (Rosmarinus officinalis L.).
Autorzy :
Yousef M; Department of Health Sciences, Brock University, St. Catharines, Ontario, Canada.
Crozier RWE; Department of Health Sciences, Brock University, St. Catharines, Ontario, Canada.
Hicks NJ; Department of Health Sciences, Brock University, St. Catharines, Ontario, Canada.
Watson CJF; Department of Health Sciences, Brock University, St. Catharines, Ontario, Canada.
Boyd T; Department of Health Sciences, Brock University, St. Catharines, Ontario, Canada.
Tsiani E; Department of Health Sciences, Brock University, St. Catharines, Ontario, Canada.
MacNeil AJ; Department of Health Sciences, Brock University, St. Catharines, Ontario, Canada.
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Źródło :
Journal of leukocyte biology [J Leukoc Biol] 2020 May; Vol. 107 (5), pp. 843-857. Date of Electronic Publication: 2020 Mar 23.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Degranulation/*drug effects
Mast Cells/*drug effects
Mast Cells/*immunology
Plant Extracts/*pharmacology
Allergens/immunology ; Animals ; Cell Degranulation/immunology ; Mice ; Rosmarinus/immunology
Czasopismo naukowe
Tytuł :
[MRGPRX2, pseudo-allergies reloaded: a step forward and two backwards].
Autorzy :
Spoerl D; Service d'immunologie et d'allergologie, Département des spécialités de médecine, HUG, 1211 Genève 14.
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Transliterated Title :
MRGPRX2, le retour des pseudo-allergies : un pas en avant et deux en arrière.
Źródło :
Revue medicale suisse [Rev Med Suisse] 2020 Apr 08; Vol. 16 (689), pp. 679-682.
Typ publikacji :
Journal Article; Review
MeSH Terms :
Cell Degranulation*/drug effects
Drug Hypersensitivity*/genetics
Drug Hypersensitivity*/metabolism
Mast Cells/*metabolism
Dose-Response Relationship, Immunologic ; Humans ; Nerve Tissue Proteins/metabolism ; Receptors, G-Protein-Coupled/metabolism ; Receptors, Neuropeptide/metabolism
Czasopismo naukowe
Tytuł :
Clinical significance of serum MRGPRX2 as a new biomarker in allergic asthma.
Autorzy :
An J; Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Lee JH; Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Won HK; Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.; Department of Internal Medicine, Veterans Health Service Medical Center, Seoul, Korea.
Kang Y; Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.; Department of Internal Medicine, Pusan National University School of Medicine, Pusan, Korea.
Song WJ; Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Kwon HS; Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Cho YS; Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Moon HB; Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Kim TB; Department of Allergy and Clinical Immunology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
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Źródło :
Allergy [Allergy] 2020 Apr; Vol. 75 (4), pp. 959-962. Date of Electronic Publication: 2019 Oct 31.
Typ publikacji :
Letter; Research Support, Non-U.S. Gov't
MeSH Terms :
Asthma*/diagnosis
Cell Degranulation*
Nerve Tissue Proteins/*blood
Receptors, G-Protein-Coupled/*blood
Receptors, Neuropeptide/*blood
Biomarkers ; Humans
Raport

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