Temat: "Cell Hypoxia" - OpacWWW

Skocz do pozycji: 61.

Tytuł:: Expression Dynamics of CA IX Epitope in Cancer Cells under Intermittent Hypoxia Correlates with Extracellular pH Drop and Cell Killing by Ureido-Sulfonamide CA IX Inhibitors.
Autorzy:: Sufian MA; Department of Pharmaceutical Sciences and Moulder Center for Drug Discovery Research, School of Pharmacy, Temple University, 3307 North Broad Street, Philadelphia, PA 19140, USA.
Zamanova S; Department of Pharmaceutical Sciences and Moulder Center for Drug Discovery Research, School of Pharmacy, Temple University, 3307 North Broad Street, Philadelphia, PA 19140, USA.
Shabana AM; Department of Pharmaceutical Sciences and Moulder Center for Drug Discovery Research, School of Pharmacy, Temple University, 3307 North Broad Street, Philadelphia, PA 19140, USA.; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo 11562, Egypt.
Kemp B; Department of Pharmaceutical Sciences and Moulder Center for Drug Discovery Research, School of Pharmacy, Temple University, 3307 North Broad Street, Philadelphia, PA 19140, USA.
Mondal UK; Department of Pharmaceutical Sciences and Moulder Center for Drug Discovery Research, School of Pharmacy, Temple University, 3307 North Broad Street, Philadelphia, PA 19140, USA.
Supuran CT; NEUROFARBA Department, Pharmaceutical Sciences Section, Universita degli Studi di Firenze, Polo Scientifico, Via Ugo Schiff No. 6, 50019 Sesto Fiorentino, Florence, Italy.
Ilies MA; Department of Pharmaceutical Sciences and Moulder Center for Drug Discovery Research, School of Pharmacy, Temple University, 3307 North Broad Street, Philadelphia, PA 19140, USA.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Feb 27; Vol. 24 (5). Date of Electronic Publication: 2023 Feb 27.
Typ publikacji:: Journal Article
MeSH Terms:: Carbonic Anhydrases*/metabolism
Ovarian Neoplasms*
Female ; Humans ; Carbonic Anhydrase IX/metabolism ; Carbonic Anhydrase Inhibitors/pharmacology ; Antigens, Neoplasm/metabolism ; Hypoxia ; Cell Hypoxia ; Sulfonamides/pharmacology ; Hydrogen-Ion Concentration ; Cell Death ; Cell Line, Tumor

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Skocz do pozycji: 62.

Tytuł:: Hypoxia Inhibits Cell Cycle Progression and Cell Proliferation in Brain Microvascular Endothelial Cells via the miR-212-3p/MCM2 Axis.
Autorzy:: Shi Q; Department of Aerospace Physiology, Air Force Medical University, Xi'an 710032, China.
Li S; Department of Aerospace Physiology, Air Force Medical University, Xi'an 710032, China.
Lyu Q; Department of Aerospace Physiology, Air Force Medical University, Xi'an 710032, China.
Zhang S; Department of Aerospace Physiology, Air Force Medical University, Xi'an 710032, China.
Bai Y; Department of Aerospace Physiology, Air Force Medical University, Xi'an 710032, China.
Ma J; Department of Aerospace Physiology, Air Force Medical University, Xi'an 710032, China.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2023 Feb 01; Vol. 24 (3). Date of Electronic Publication: 2023 Feb 01.
Typ publikacji:: Journal Article
MeSH Terms:: Endothelial Cells*/metabolism
MicroRNAs*/genetics
MicroRNAs*/metabolism
Humans ; Minichromosome Maintenance Complex Component 2/genetics ; Minichromosome Maintenance Complex Component 2/metabolism ; Brain/metabolism ; Cell Proliferation/genetics ; Cell Division ; Hypoxia/genetics ; Hypoxia/metabolism ; Cell Hypoxia/genetics

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Skocz do pozycji: 63.

Tytuł:: Impact of hypoxia on the double-strand break repair after photon and carbon ion irradiation of radioresistant HNSCC cells.
Autorzy:: Wozny AS; UMR CNRS5822/IN2P3, IP2I, PRISME, Laboratoire de Radiobiologie Cellulaire et Moléculaire, Faculté de Médecine Lyon-Sud, Univ Lyon, Université Lyon, 69921, Oullins Cedex, France.; Service de Biochimie et Biologie Moléculaire, Hospices Civils de Lyon, Centre Hospitalier Lyon-Sud, 69495, Pierre-Bénite, France.
Alphonse G; UMR CNRS5822/IN2P3, IP2I, PRISME, Laboratoire de Radiobiologie Cellulaire et Moléculaire, Faculté de Médecine Lyon-Sud, Univ Lyon, Université Lyon, 69921, Oullins Cedex, France.; Service de Biochimie et Biologie Moléculaire, Hospices Civils de Lyon, Centre Hospitalier Lyon-Sud, 69495, Pierre-Bénite, France.
Cassard A; UMR CNRS5822/IN2P3, IP2I, PRISME, Laboratoire de Radiobiologie Cellulaire et Moléculaire, Faculté de Médecine Lyon-Sud, Univ Lyon, Université Lyon, 69921, Oullins Cedex, France.
Malésys C; UMR CNRS5822/IN2P3, IP2I, PRISME, Laboratoire de Radiobiologie Cellulaire et Moléculaire, Faculté de Médecine Lyon-Sud, Univ Lyon, Université Lyon, 69921, Oullins Cedex, France.
Louati S; UMR CNRS5822/IN2P3, IP2I, PRISME, Laboratoire de Radiobiologie Cellulaire et Moléculaire, Faculté de Médecine Lyon-Sud, Univ Lyon, Université Lyon, 69921, Oullins Cedex, France.; Département de Radiothérapie, Institut de Cancérologie de la Loire Lucien Neuwirth, 42270, St Priest-en-Jarez, France.
Beuve M; UMR CNRS5822 /IN2P3, IP2I, PRISME, Univ Lyon, Université Lyon 1, 69322, Villeurbanne, France.
Lalle P; UMR CNRS5822/IN2P3, IP2I, PRISME, Laboratoire de Radiobiologie Cellulaire et Moléculaire, Faculté de Médecine Lyon-Sud, Univ Lyon, Université Lyon, 69921, Oullins Cedex, France.
Ardail D; UMR CNRS5822/IN2P3, IP2I, PRISME, Laboratoire de Radiobiologie Cellulaire et Moléculaire, Faculté de Médecine Lyon-Sud, Univ Lyon, Université Lyon, 69921, Oullins Cedex, France.; Service de Biochimie et Biologie Moléculaire, Hospices Civils de Lyon, Centre Hospitalier Lyon-Sud, 69495, Pierre-Bénite, France.
Nakajima T; Department of Radiation Effects Research, National Institute of Radiological Sciences, National Institute for Quantum and Radiological Science and Technology, Inage-ku, Chiba, 263-8555, Japan.
Rodriguez-Lafrasse C; UMR CNRS5822/IN2P3, IP2I, PRISME, Laboratoire de Radiobiologie Cellulaire et Moléculaire, Faculté de Médecine Lyon-Sud, Univ Lyon, Université Lyon, 69921, Oullins Cedex, France. .; Service de Biochimie et Biologie Moléculaire, Hospices Civils de Lyon, Centre Hospitalier Lyon-Sud, 69495, Pierre-Bénite, France. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2020 Dec 07; Vol. 10 (1), pp. 21357. Date of Electronic Publication: 2020 Dec 07.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Cell Hypoxia/*physiology
DNA Breaks, Double-Stranded/*radiation effects
Squamous Cell Carcinoma of Head and Neck/*genetics
Cell Cycle/genetics ; Cell Cycle/radiation effects ; Cell Hypoxia/genetics ; Cell Line, Tumor ; Cyclin-Dependent Kinase Inhibitor p16/genetics ; Fluorescent Antibody Technique ; Genotype ; Heavy Ion Radiotherapy ; Humans ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/radiation effects ; Squamous Cell Carcinoma of Head and Neck/radiotherapy ; Tumor Microenvironment/genetics ; Tumor Microenvironment/radiation effects ; Tumor Suppressor Protein p53/genetics ; X-Rays

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Skocz do pozycji: 64.

Tytuł:: MicroRNA‑494 suppresses hypoxia/reoxygenation‑induced cardiomyocyte apoptosis and autophagy via the PI3K/AKT/mTOR signaling pathway by targeting SIRT1.
Autorzy:: Ning S; Laboratory of Cardiovascular Disease and Drug Research, Zhengzhou No. 7 People's Hospital, Zhengzhou, Henan 450016, P.R. China.
Li Z; Laboratory of Cardiovascular Disease and Drug Research, Zhengzhou No. 7 People's Hospital, Zhengzhou, Henan 450016, P.R. China.
Ji Z; Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Fan D; Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Wang K; Laboratory of Cardiovascular Disease and Drug Research, Zhengzhou No. 7 People's Hospital, Zhengzhou, Henan 450016, P.R. China.
Wang Q; Laboratory of Cardiovascular Disease and Drug Research, Zhengzhou No. 7 People's Hospital, Zhengzhou, Henan 450016, P.R. China.
Hua L; Laboratory of Cardiovascular Disease and Drug Research, Zhengzhou No. 7 People's Hospital, Zhengzhou, Henan 450016, P.R. China.
Zhang J; Laboratory of Cardiovascular Disease and Drug Research, Zhengzhou No. 7 People's Hospital, Zhengzhou, Henan 450016, P.R. China.
Meng X; Laboratory of Cardiovascular Disease and Drug Research, Zhengzhou No. 7 People's Hospital, Zhengzhou, Henan 450016, P.R. China.
Yuan Y; Department of Cardiovascular Internal Medicine, Henan Provincial Chest Hospital, Zhengzhou, Henan 450003, P.R. China.; Pokaż więcej
Źródło:: Molecular medicine reports [Mol Med Rep] 2020 Dec; Vol. 22 (6), pp. 5231-5242. Date of Electronic Publication: 2020 Oct 26.
Typ publikacji:: Journal Article
MeSH Terms:: Cell Hypoxia/*genetics
MicroRNAs/*genetics
Myocytes, Cardiac/*metabolism
Animals ; Apoptosis/genetics ; Autophagy/genetics ; Cell Hypoxia/physiology ; Cell Line ; Hypoxia/genetics ; Hypoxia/metabolism ; MicroRNAs/metabolism ; Myocardial Infarction/metabolism ; Myocardial Reperfusion Injury/metabolism ; Myocytes, Cardiac/physiology ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Rats ; Signal Transduction/drug effects ; Sirtuin 1/metabolism ; TOR Serine-Threonine Kinases/metabolism

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Skocz do pozycji: 65.

Tytuł:: Hypoxia as a Driving Force of Pluripotent Stem Cell Reprogramming and Differentiation to Endothelial Cells.
Autorzy:: Podkalicka P; Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Kraków, Poland.
Stępniewski J; Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Kraków, Poland.
Mucha O; Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Kraków, Poland.
Kachamakova-Trojanowska N; Malopolska Centre of Biotechnology, Jagiellonian University, 30-837 Kraków, Poland.
Dulak J; Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Kraków, Poland.
Łoboda A; Department of Medical Biotechnology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Kraków, Poland.; Pokaż więcej
Źródło:: Biomolecules [Biomolecules] 2020 Nov 29; Vol. 10 (12). Date of Electronic Publication: 2020 Nov 29.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:: Cell Hypoxia*
Endothelial Cells/*cytology
Pluripotent Stem Cells/*cytology
Cell Differentiation ; Humans ; Oxygen/metabolism

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Skocz do pozycji: 66.

Tytuł:: Construction and investigation of a combined hypoxia and stemness index lncRNA-associated ceRNA regulatory network in lung adenocarcinoma.
Autorzy:: Guo L; Department of Medical Oncology, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital Medical University, No. 1 Beiguandajie, Tongzhou District, Beijing, 101149, China.
Li H; Department of Medical Oncology, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital Medical University, No. 1 Beiguandajie, Tongzhou District, Beijing, 101149, China.
Li W; Department of Cellular and Molecular Biology, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital Medical University, Beijing, 101149, China.
Tang J; Department of Medical Oncology, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital Medical University, No. 1 Beiguandajie, Tongzhou District, Beijing, 101149, China. .; Pokaż więcej
Źródło:: BMC medical genomics [BMC Med Genomics] 2020 Nov 04; Vol. 13 (1), pp. 166. Date of Electronic Publication: 2020 Nov 04.
Typ publikacji:: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Cell Hypoxia*
Cell Self Renewal*
Gene Expression Regulation, Neoplastic*
Gene Regulatory Networks*
Adenocarcinoma of Lung/*genetics
Lung Neoplasms/*genetics
Neoplastic Stem Cells/*pathology
RNA, Long Noncoding/*genetics
RNA, Neoplasm/*genetics
Adenocarcinoma of Lung/metabolism ; Adenocarcinoma of Lung/mortality ; Cluster Analysis ; Datasets as Topic ; Humans ; Kaplan-Meier Estimate ; Lung Neoplasms/metabolism ; Lung Neoplasms/mortality ; MicroRNAs/genetics ; Prognosis ; RNA, Long Noncoding/biosynthesis ; RNA, Messenger/biosynthesis ; RNA, Messenger/genetics ; RNA, Neoplasm/biosynthesis ; RNA, Neoplasm/classification

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Skocz do pozycji: 67.

Tytuł:: IRE1 Endoribonuclease Activity Modulates Hypoxic HIF-1α Signaling in Human Endothelial Cells.
Autorzy:: Moszyńska A; Department of Biology and Pharmaceutical Botany, Medical University of Gdansk, 80210 Gdansk, Poland.
Collawn JF; Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Bartoszewski R; Department of Biology and Pharmaceutical Botany, Medical University of Gdansk, 80210 Gdansk, Poland.; Pokaż więcej
Źródło:: Biomolecules [Biomolecules] 2020 Jun 11; Vol. 10 (6). Date of Electronic Publication: 2020 Jun 11.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Cell Hypoxia*/drug effects
Cell Hypoxia*/genetics
Endoribonucleases/*physiology
Endothelial Cells/*metabolism
Hypoxia-Inducible Factor 1, alpha Subunit/*physiology
Protein Serine-Threonine Kinases/*physiology
Cells, Cultured ; Endoribonucleases/antagonists & inhibitors ; Endoribonucleases/metabolism ; Endothelial Cells/drug effects ; Gene Knockdown Techniques ; Human Umbilical Vein Endothelial Cells ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Protein Serine-Threonine Kinases/antagonists & inhibitors ; Protein Serine-Threonine Kinases/metabolism ; RNA, Small Interfering/pharmacology ; Signal Transduction/drug effects ; Signal Transduction/genetics

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Skocz do pozycji: 68.

Tytuł:: Replicative Senescence and Expression of Autophagy Genes in Mesenchymal Stromal Cells.
Autorzy:: Ratushnyy AY; Institute of Biomedical Problems (IBMP), Russian Academy of Sciences, Moscow, 123007, Russia. .
Rudimova YV; Institute of Biomedical Problems (IBMP), Russian Academy of Sciences, Moscow, 123007, Russia.
Buravkova LB; Institute of Biomedical Problems (IBMP), Russian Academy of Sciences, Moscow, 123007, Russia.; Pokaż więcej
Źródło:: Biochemistry. Biokhimiia [Biochemistry (Mosc)] 2020 Oct; Vol. 85 (10), pp. 1169-1177.
Typ publikacji:: Journal Article
MeSH Terms:: Autophagy*
Cell Hypoxia*
Cellular Senescence*
Mesenchymal Stem Cells*/cytology
Mesenchymal Stem Cells*/metabolism
Cells, Cultured ; Humans ; Lysosomes/metabolism

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Skocz do pozycji: 69.

Tytuł:: Ischemia/reperfusion injured intestinal epithelial cells cause cortical neuron death by releasing exosomal microRNAs associated with apoptosis, necroptosis, and pyroptosis.
Autorzy:: Hsu CC; Department of Biotechnology and Food Technology, Southern Taiwan University of Science and Technology, No. 1, Nan-Tai Street, Yungkang District, Tainan City, 710, Taiwan.; Department of Emergency Medicine, Chi Mei Medical Center, No. 901, Zhonghua Road, Yongkang District, Tainan City, 710, Taiwan.
Huang CC; Department of Emergency Medicine, Chi Mei Medical Center, No. 901, Zhonghua Road, Yongkang District, Tainan City, 710, Taiwan.; Department of Senior Services, Southern Taiwan University of Science and Technology, No. 1, Nan-Tai Street, Yungkang District, Tainan City, 710, Taiwan.; Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, No. 1, University Road, Tainan City, 710, Taiwan.; Department of Geriatrics and Gerontology, Chi-Mei Medical Center, No. 901, Zhonghua Road, Yongkang District, Tainan City, 710, Taiwan.; Department of Occupational Medicine, Chi-Mei Medical Center, No. 901, Zhonghua Road, Yongkang District, Tainan City, 710, Taiwan.
Chien LH; Department of Medical Research, Chi Mei Medical Center, No. 901, Zhonghua Road, Yongkang District, Tainan City, 710, Taiwan.
Lin MT; Department of Medical Research, Chi Mei Medical Center, No. 901, Zhonghua Road, Yongkang District, Tainan City, 710, Taiwan.
Chang CP; Department of Medical Research, Chi Mei Medical Center, No. 901, Zhonghua Road, Yongkang District, Tainan City, 710, Taiwan. .
Lin HJ; Department of Emergency Medicine, Chi Mei Medical Center, No. 901, Zhonghua Road, Yongkang District, Tainan City, 710, Taiwan. .; Department of Medicine, Taipei Medical University, No. 250 Wu-Hsing Street, Taipei City, 110, Taiwan. .
Chio CC; Division of Neurosurgery, Department of Surgery, Chi Mei Medical Center, No. 901, Zhonghua Road, Yongkang District, Tainan City, 710, Taiwan. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2020 Sep 01; Vol. 10 (1), pp. 14409. Date of Electronic Publication: 2020 Sep 01.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Cell Hypoxia*
Necroptosis*
Pyroptosis*
Cerebral Cortex/*cytology
Epithelial Cells/*metabolism
Exosomes/*metabolism
Glucose/*metabolism
Intestinal Mucosa/*cytology
MicroRNAs/*metabolism
Neurons/*metabolism
Animals ; Cell Line ; Cell Survival ; Cerebral Cortex/embryology ; Coculture Techniques ; Hypothermia/metabolism ; Rats ; Rats, Sprague-Dawley ; Reperfusion Injury/metabolism

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Skocz do pozycji: 70.

Tytuł:: Hypoxic gene expression in chronic hepatitis B virus infected patients is not observed in state-of-the-art in vitro and mouse infection models.
Autorzy:: Liu PJ; Nuffield Department of Medicine Research Building, University of Oxford, Oxford, OX3 7LF, UK.
Harris JM; Nuffield Department of Medicine Research Building, University of Oxford, Oxford, OX3 7LF, UK.
Marchi E; Medawar Building, University of Oxford, South Parks Road, Oxford, OX1 3SY, UK.
D'Arienzo V; Nuffield Department of Medicine Research Building, University of Oxford, Oxford, OX3 7LF, UK.
Michler T; Institute of Virology, Technical University of Munich/Helmholtz Zentrum München, Trogerstrasse 30, 81675, Munich, Germany.
Wing PAC; Nuffield Department of Medicine Research Building, University of Oxford, Oxford, OX3 7LF, UK.
Magri A; Nuffield Department of Medicine Research Building, University of Oxford, Oxford, OX3 7LF, UK.
Ortega-Prieto AM; Section of Molecular Virology, Department of Infectious Diseases, Imperial College London, London, W2 1PG, UK.
van de Klundert M; Institute of Virology, Technical University of Munich/Helmholtz Zentrum München, Trogerstrasse 30, 81675, Munich, Germany.
Wettengel J; Institute of Virology, Technical University of Munich/Helmholtz Zentrum München, Trogerstrasse 30, 81675, Munich, Germany.
Durantel D; Cancer Research Center of Lyon (CRCL), INSERM U1052, and University of Lyon (UCBL1), Lyon, France.
Dorner M; Section of Molecular Virology, Department of Infectious Diseases, Imperial College London, London, W2 1PG, UK.
Klenerman P; Medawar Building, University of Oxford, South Parks Road, Oxford, OX1 3SY, UK.
Protzer U; Institute of Virology, Technical University of Munich/Helmholtz Zentrum München, Trogerstrasse 30, 81675, Munich, Germany.
Giotis ES; Section of Molecular Virology, Department of Infectious Diseases, Imperial College London, London, W2 1PG, UK.; School of Life Sciences, University of Essex, Colchester, C04 3SQ, UK.
McKeating JA; Nuffield Department of Medicine Research Building, University of Oxford, Oxford, OX3 7LF, UK. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2020 Aug 24; Vol. 10 (1), pp. 14101. Date of Electronic Publication: 2020 Aug 24.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Basic Helix-Loop-Helix Transcription Factors/*metabolism
Cell Hypoxia/*genetics
Hepatitis B, Chronic/*pathology
Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism
Hypoxia-Inducible Factor-Proline Dioxygenases/*metabolism
Trans-Activators/*metabolism
Viral Regulatory and Accessory Proteins/*metabolism
Animals ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Cell Hypoxia/physiology ; Cell Line, Tumor ; Disease Models, Animal ; Female ; Hep G2 Cells ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Liver/metabolism ; Liver Cirrhosis/pathology ; Liver Cirrhosis/virology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Oxidative Stress/physiology ; Oxygen/metabolism

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Skocz do pozycji: 71.

Tytuł:: Role of endoplasmic reticulum oxidase 1α in H9C2 cardiomyocytes following hypoxia/reoxygenation injury.
Autorzy:: Lai L; Department of Pharmacology, Changzhi Medical College, Changzhi, Shanxi 046000, P.R. China.
Liu Y; Department of Clinical Medicine, Changzhi Medical College, Changzhi, Shanxi 046000, P.R. China.
Liu Y; Department of Clinical Medicine, Changzhi Medical College, Changzhi, Shanxi 046000, P.R. China.
Zhang N; Department of Clinical Medicine, Changzhi Medical College, Changzhi, Shanxi 046000, P.R. China.
Cao S; Department of Clinical Medicine, Changzhi Medical College, Changzhi, Shanxi 046000, P.R. China.
Zhang X; Department of Pharmacology, Changzhi Medical College, Changzhi, Shanxi 046000, P.R. China.
Wu D; Department of Surgery, University of Virginia, Charlottesville, VA 22908, USA.; Pokaż więcej
Źródło:: Molecular medicine reports [Mol Med Rep] 2020 Aug; Vol. 22 (2), pp. 1420-1428. Date of Electronic Publication: 2020 Jun 09.
Typ publikacji:: Journal Article
MeSH Terms:: Cell Hypoxia*
Myocytes, Cardiac*/metabolism
Myocytes, Cardiac*/pathology
Endoplasmic Reticulum/*metabolism
Membrane Glycoproteins/*physiology
Myocardial Reperfusion Injury/*metabolism
Animals ; Apoptosis ; Cell Line ; Endoplasmic Reticulum Stress ; Mitochondria/metabolism ; Rats ; Reactive Oxygen Species/metabolism

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Skocz do pozycji: 72.

Tytuł:: Metabolic pathway alterations in microvascular endothelial cells in response to hypoxia.
Autorzy:: Cohen EB; Department of Pathology and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America.
Geck RC; Department of Pathology and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America.
Toker A; Department of Pathology and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America.; Ludwig Center at Harvard, Harvard Medical School, Boston, Massachusetts, United States of America.; Pokaż więcej
Źródło:: PloS one [PLoS One] 2020 Jul 09; Vol. 15 (7), pp. e0232072. Date of Electronic Publication: 2020 Jul 09 (Print Publication: 2020).
Typ publikacji:: Journal Article; Research Support, N.I.H., Extramural
MeSH Terms:: Cell Hypoxia*
Metabolic Networks and Pathways*
Endothelial Cells/*metabolism
Amino Acids/metabolism ; Aspartic Acid/metabolism ; Cell Line ; Cysteine/metabolism ; HEK293 Cells ; Humans ; Microvessels/metabolism ; Nucleotides/metabolism

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Skocz do pozycji: 73.

Tytuł:: The Hyperoxic-Hypoxic Paradox.
Autorzy:: Hadanny A; The Sagol Center for Hyperbaric Medicine and Research, Shamir (Assaf-Harofeh) Medical Center, Zerifin 70300, Israel.; Sackler School of Medicine, Tel-Aviv University, Tel-Aviv 6997801, Israel.; The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat-Gan 5290002, Israel.
Efrati S; The Sagol Center for Hyperbaric Medicine and Research, Shamir (Assaf-Harofeh) Medical Center, Zerifin 70300, Israel.; Sackler School of Medicine, Tel-Aviv University, Tel-Aviv 6997801, Israel.; The Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv 6997801, Israel.; Pokaż więcej
Źródło:: Biomolecules [Biomolecules] 2020 Jun 25; Vol. 10 (6). Date of Electronic Publication: 2020 Jun 25.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't; Review
MeSH Terms:: Cell Hypoxia*
Hyperoxia/*metabolism
Oxygen/*metabolism
Animals ; Humans

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Skocz do pozycji: 74.

Tytuł:: HIF‑1α affects trophoblastic apoptosis involved in the onset of preeclampsia by regulating FOXO3a under hypoxic conditions.
Autorzy:: Zhang Z; Department of Clinical Laboratory, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Huang C; Department of Clinical Laboratory, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Wang P; Department of Clinical Laboratory, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Gao J; Department of Clinical Laboratory, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Liu X; Department of Clinical Laboratory, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Li Y; Department of Clinical Laboratory, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Yan S; Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Shi Y; Department of Clinical Laboratory, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.; Pokaż więcej
Źródło:: Molecular medicine reports [Mol Med Rep] 2020 Jun; Vol. 21 (6), pp. 2484-2492. Date of Electronic Publication: 2020 Apr 01.
Typ publikacji:: Journal Article
MeSH Terms:: Apoptosis*/drug effects
Cell Hypoxia*
Forkhead Box Protein O3/*metabolism
Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism
Pre-Eclampsia/*pathology
Adult ; Case-Control Studies ; Cell Line ; Cobalt/pharmacology ; Female ; Forkhead Box Protein O3/antagonists & inhibitors ; Forkhead Box Protein O3/genetics ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/antagonists & inhibitors ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Placenta/metabolism ; Pre-Eclampsia/metabolism ; Pregnancy ; RNA Interference ; RNA, Small Interfering/metabolism ; Trophoblasts/cytology ; Trophoblasts/metabolism ; Up-Regulation/drug effects

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Skocz do pozycji: 75.

Tytuł:: Role of the Nrdp1 in Brain Injury Induced by Chronic Intermittent Hypoxia in Rats via Regulating the Protein Levels of ErbB3.
Autorzy:: Zhu J; Department of Emergency, Guizhou Provincial People's Hospital, Guiyang, China.
Zhu Z; Department of Emergency, Affiliated Hospital of Guizhou Medical University, Guiyang, China.
Ren Y; Department of Emergency, Guizhou Provincial People's Hospital, Guiyang, China.
Dong Y; Department of Emergency, Guizhou Provincial People's Hospital, Guiyang, China.
Li Y; Department of Emergency, Guizhou Provincial People's Hospital, Guiyang, China.
Yang X; Department of Emergency, Guizhou Provincial People's Hospital, Guiyang, China. .; Pokaż więcej
Źródło:: Neurotoxicity research [Neurotox Res] 2020 Jun; Vol. 38 (1), pp. 124-132. Date of Electronic Publication: 2020 Mar 21.
Typ publikacji:: Journal Article
MeSH Terms:: Cell Hypoxia*
Brain Injuries/*metabolism
Receptor, ErbB-3/*metabolism
Sleep Apnea, Obstructive/*metabolism
Ubiquitin-Protein Ligases/*metabolism
Animals ; Brain Injuries/etiology ; Brain Injuries/pathology ; Disease Models, Animal ; Hippocampus/metabolism ; Hippocampus/pathology ; Male ; Neurons/metabolism ; Neurons/pathology ; Rats, Wistar ; Sleep Apnea, Obstructive/complications

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Skocz do pozycji: 76.

Tytuł:: Long non‑coding RNA NORAD regulates angiogenesis of human umbilical vein endothelial cells via miR‑590‑3p under hypoxic conditions.
Autorzy:: Zhao X; Department of Geriatrics, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.
Wei X; Department of Geriatrics, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.
Wang X; Department of Geriatrics, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.
Qi G; Department of Geriatrics, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China.; Pokaż więcej
Źródło:: Molecular medicine reports [Mol Med Rep] 2020 Jun; Vol. 21 (6), pp. 2560-2570. Date of Electronic Publication: 2020 Apr 08.
Typ publikacji:: Journal Article
MeSH Terms:: Cell Hypoxia*
MicroRNAs/*metabolism
RNA, Long Noncoding/*metabolism
Animals ; Antagomirs/metabolism ; Cell Movement ; Fibroblast Growth Factor 1/chemistry ; Fibroblast Growth Factor 1/genetics ; Fibroblast Growth Factor 1/metabolism ; Human Umbilical Vein Endothelial Cells ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; MicroRNAs/antagonists & inhibitors ; MicroRNAs/genetics ; Myocardial Infarction/pathology ; Neovascularization, Physiologic ; RNA Interference ; RNA, Long Noncoding/antagonists & inhibitors ; RNA, Long Noncoding/genetics ; RNA, Small Interfering/metabolism ; Vascular Endothelial Growth Factor A/chemistry ; Vascular Endothelial Growth Factor A/genetics ; Vascular Endothelial Growth Factor A/metabolism

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Skocz do pozycji: 77.

Tytuł:: In silico analysis of hypoxia activated prodrugs in combination with anti angiogenic therapy through nanocell delivery.
Autorzy:: Meaney C; Department of Applied Mathematics, University of Waterloo, Waterloo, Ontario, Canada.
Rhebergen S; Department of Applied Mathematics, University of Waterloo, Waterloo, Ontario, Canada.
Kohandel M; Department of Applied Mathematics, University of Waterloo, Waterloo, Ontario, Canada.; Pokaż więcej
Źródło:: PLoS computational biology [PLoS Comput Biol] 2020 May 28; Vol. 16 (5), pp. e1007926. Date of Electronic Publication: 2020 May 28 (Print Publication: 2020).
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Cell Hypoxia*
Drug Delivery Systems*
Nanotechnology*
Angiogenesis Inhibitors/*administration & dosage
Prodrugs/*administration & dosage
Computer Simulation ; Humans

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Tytuł:: Hypoxia-Induced miR-675-5p Supports β-Catenin Nuclear Localization by Regulating GSK3-β Activity in Colorectal Cancer Cell Lines.
Autorzy:: Saieva L; Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.), Section of Biology and Genetics, University of Palermo, 90133 Palermo, Italy.
Barreca MM; Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.), Section of Biology and Genetics, University of Palermo, 90133 Palermo, Italy.
Zichittella C; Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.), Section of Biology and Genetics, University of Palermo, 90133 Palermo, Italy.
Prado MG; Istituto Pasteur-Fondazione Cenci Bolognetti, Department of Molecular Medicine, Sapienza University of Rome, 00185 Rome, Italy.
Tripodi M; Istituto Pasteur-Fondazione Cenci Bolognetti, Department of Molecular Medicine, Sapienza University of Rome, 00185 Rome, Italy.; National Institute for Infectious Diseases L. Spallanzani, IRCCS, 00161 Rome, Italy.
Alessandro R; Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.), Section of Biology and Genetics, University of Palermo, 90133 Palermo, Italy.
Conigliaro A; Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.), Section of Biology and Genetics, University of Palermo, 90133 Palermo, Italy.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2020 May 28; Vol. 21 (11). Date of Electronic Publication: 2020 May 28.
Typ publikacji:: Journal Article
MeSH Terms:: Cell Hypoxia*
Gene Expression Regulation, Neoplastic*
Colorectal Neoplasms/*metabolism
Glycogen Synthase Kinase 3 beta/*metabolism
MicroRNAs/*metabolism
beta Catenin/*metabolism
Active Transport, Cell Nucleus ; Cell Line, Tumor ; Colorectal Neoplasms/genetics ; Computational Biology ; HCT116 Cells ; Humans ; Kaplan-Meier Estimate ; Microscopy, Fluorescence ; Mutation ; Protein Binding ; Transfection

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Skocz do pozycji: 79.

Tytuł:: Modeling Direct and Indirect Action on Cell Survival After Photon Irradiation under Normoxia and Hypoxia.
Autorzy:: Liew H; Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; Division of Molecular and Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital, 69120 Heidelberg, Germany.; Heidelberg Institute of Radiation Oncology (HIRO), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.; Heidelberg Ion-Beam Therapy Center (HIT), 69120 Heidelberg, Germany.; Faculty of Physics and Astronomy, Heidelberg University, 69120 Heidelberg, Germany.
Mein S; Division of Molecular and Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital, 69120 Heidelberg, Germany.; Heidelberg Institute of Radiation Oncology (HIRO), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.; Heidelberg Ion-Beam Therapy Center (HIT), 69120 Heidelberg, Germany.
Debus J; Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; Division of Molecular and Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital, 69120 Heidelberg, Germany.; Heidelberg Institute of Radiation Oncology (HIRO), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.; Heidelberg Ion-Beam Therapy Center (HIT), 69120 Heidelberg, Germany.; Faculty of Physics and Astronomy, Heidelberg University, 69120 Heidelberg, Germany.
Dokic I; Division of Molecular and Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital, 69120 Heidelberg, Germany.; Heidelberg Institute of Radiation Oncology (HIRO), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.; Heidelberg Ion-Beam Therapy Center (HIT), 69120 Heidelberg, Germany.
Mairani A; Division of Molecular and Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital, 69120 Heidelberg, Germany.; Heidelberg Institute of Radiation Oncology (HIRO), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany.; Heidelberg Ion-Beam Therapy Center (HIT), 69120 Heidelberg, Germany.; Pokaż więcej
Źródło:: International journal of molecular sciences [Int J Mol Sci] 2020 May 14; Vol. 21 (10). Date of Electronic Publication: 2020 May 14.
Typ publikacji:: Journal Article
MeSH Terms:: Cell Hypoxia/*radiation effects
Cell Survival/*radiation effects
DNA Damage/*radiation effects
Dimethyl Sulfoxide/*pharmacology
Cell Hypoxia/drug effects ; Cell Line ; Cell Survival/drug effects ; Dose-Response Relationship, Radiation ; Free Radical Scavengers/pharmacology ; Humans ; Photons/adverse effects

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Skocz do pozycji: 80.

Tytuł:: Monocarboxylate transporter 4 involves in energy metabolism and drug sensitivity in hypoxia.
Autorzy:: Yamaguchi A; Department of Pharmacy, Hokkaido University Hospital, Kita-14-Jo, Nishi-5-Chome, Kita-ku, Sapporo, 060-8648, Japan.; Laboratory of Clinical Pharmaceutics and Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12-Jo, Nishi-6-Chome, Kita-ku, Sapporo, 060-0812, Japan.
Mukai Y; Laboratory of Clinical Pharmaceutics and Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12-Jo, Nishi-6-Chome, Kita-ku, Sapporo, 060-0812, Japan.
Sakuma T; Laboratory of Clinical Pharmaceutics and Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12-Jo, Nishi-6-Chome, Kita-ku, Sapporo, 060-0812, Japan.
Narumi K; Laboratory of Clinical Pharmaceutics and Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12-Jo, Nishi-6-Chome, Kita-ku, Sapporo, 060-0812, Japan.; Education Research Center for Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12-Jo, Nishi-6-Chome, Kita-ku, Sapporo, 060-0812, Japan.
Furugen A; Laboratory of Clinical Pharmaceutics and Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12-Jo, Nishi-6-Chome, Kita-ku, Sapporo, 060-0812, Japan.
Yamada Y; Laboratory for Molecular Design for Pharmaceutics, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12-Jo, Nishi-6-Chome, Kita-ku, Sapporo, 060-0812, Japan.
Kobayashi M; Laboratory of Clinical Pharmaceutics and Therapeutics, Division of Pharmasciences, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12-Jo, Nishi-6-Chome, Kita-ku, Sapporo, 060-0812, Japan. .; Education Research Center for Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Hokkaido University, Kita-12-Jo, Nishi-6-Chome, Kita-ku, Sapporo, 060-0812, Japan. .; Pokaż więcej
Źródło:: Scientific reports [Sci Rep] 2023 Jan 27; Vol. 13 (1), pp. 1501. Date of Electronic Publication: 2023 Jan 27.
Typ publikacji:: Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms:: Hypoxia*/genetics
Hypoxia*/metabolism
Metformin*/pharmacology
Humans ; Cell Hypoxia ; Cell Line, Tumor ; Energy Metabolism ; Glycolysis ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Muscle Proteins/metabolism ; Monocarboxylic Acid Transporters/metabolism

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