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Tytuł :
Activity of the human immortalized endothelial progenitor cell line HEPC-CB.1 supporting in vitro angiogenesis.
Autorzy :
Kantor A; Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114, Wroclaw, Poland. .
Krawczenko A; Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114, Wroclaw, Poland.
Bielawska-Pohl A; Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114, Wroclaw, Poland.
Duś D; Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114, Wroclaw, Poland.
Grillon C; Centre de Biophysique Moléculaire, CNRS UPR 4301, Rue Charles Sadron, 45071, Orléans, France.
Kieda C; Centre de Biophysique Moléculaire, CNRS UPR 4301, Rue Charles Sadron, 45071, Orléans, France.
Charkiewicz K; Medical University of Bialystok, M. Sklodowskiej-Curie 24A, 15-276, Bialystok, Poland.
Paprocka M; Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Rudolfa Weigla 12, 53-114, Wroclaw, Poland.
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Źródło :
Molecular biology reports [Mol Biol Rep] 2020 Aug; Vol. 47 (8), pp. 5911-5925. Date of Electronic Publication: 2020 Jul 23.
Typ publikacji :
Journal Article
MeSH Terms :
Neovascularization, Physiologic*
Cell Line, Transformed/*cytology
Endothelial Progenitor Cells/*cytology
Angiogenic Proteins/biosynthesis ; Angiogenic Proteins/genetics ; Antigens, CD/biosynthesis ; Antigens, CD/genetics ; Cell Differentiation/drug effects ; Cell Division ; Cell Hypoxia ; Cell Line, Transformed/drug effects ; Clone Cells ; Coculture Techniques ; Colony-Forming Units Assay ; Cyclic AMP/pharmacology ; Cytokines/biosynthesis ; Endothelial Cells/cytology ; Endothelial Progenitor Cells/drug effects ; Fetal Blood/cytology ; HLA Antigens/analysis ; Human Umbilical Vein Endothelial Cells ; Humans ; Oxygen/pharmacology ; RNA, Messenger/biosynthesis ; RNA, Messenger/genetics ; Real-Time Polymerase Chain Reaction ; Tretinoin/pharmacology ; Vascular Endothelial Growth Factor A/pharmacology
Czasopismo naukowe
Tytuł :
Caffeine disrupts ataxia telangiectasia mutated gene-related pathways and exacerbates acetaminophen toxicity in human fetal immortalized hepatocytes.
Autorzy :
Viswanathan P; Division of Pediatric Gastroenterology and Department of Pediatrics, Children's Hospital at Montefiore, USA.
Gupta P; Department of Medicine, USA.
Sharma Y; Department of Medicine, USA.
Maisuradze L; Department of Medicine, USA.
Bandi S; Department of Medicine, USA; Marion Bessin Liver Research Center, USA.
Gupta S; Department of Medicine, USA; Marion Bessin Liver Research Center, USA; Department of Pathology, USA; Diabetes Center, USA; Fleischer Institute for Diabetes and Metabolism, USA; Irwin S. and Sylvia Chanin Institute for Cancer Research, USA; Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, New York, USA. Electronic address: .
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Źródło :
Toxicology [Toxicology] 2021 Jun 15; Vol. 457, pp. 152811. Date of Electronic Publication: 2021 May 07.
Typ publikacji :
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
MeSH Terms :
Acetaminophen/*toxicity
Ataxia Telangiectasia Mutated Proteins/*antagonists & inhibitors
Ataxia Telangiectasia Mutated Proteins/*metabolism
Caffeine/*toxicity
Hepatocytes/*drug effects
Hepatocytes/*metabolism
Acetaminophen/administration & dosage ; Caffeine/administration & dosage ; Cell Line, Transformed ; Cell Survival/drug effects ; Cell Survival/physiology ; Cells, Cultured ; Central Nervous System Stimulants/administration & dosage ; Central Nervous System Stimulants/toxicity ; Fetus ; Humans ; Organoids/drug effects ; Organoids/metabolism
Czasopismo naukowe
Tytuł :
Dissecting the novel mechanism of reduning injection in treating Coronavirus Disease 2019 (COVID-19) based on network pharmacology and experimental verification.
Autorzy :
Jia S; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Luo H; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, 999078, China. Electronic address: .
Liu X; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Fan X; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Huang Z; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Lu S; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Shen L; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Guo S; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Liu Y; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Wang Z; State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, Jiangsu, 222001, China; The Key Laboratory for the New Technique Research of TCM Extraction and Purification, Lianyungang, Jiangsu, 222047, China. Electronic address: .
Cao L; State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, Jiangsu, 222001, China; The Key Laboratory for the New Technique Research of TCM Extraction and Purification, Lianyungang, Jiangsu, 222047, China. Electronic address: .
Cao Z; State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, Jiangsu, 222001, China; The Key Laboratory for the New Technique Research of TCM Extraction and Purification, Lianyungang, Jiangsu, 222047, China. Electronic address: .
Zhang X; State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, Jiangsu, 222001, China; The Key Laboratory for the New Technique Research of TCM Extraction and Purification, Lianyungang, Jiangsu, 222047, China. Electronic address: .
Zhou W; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Zhang J; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Li J; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Wu J; Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, 100102, China. Electronic address: .
Xiao W; State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, Jiangsu, 222001, China; The Key Laboratory for the New Technique Research of TCM Extraction and Purification, Lianyungang, Jiangsu, 222047, China. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2021 Jun 12; Vol. 273, pp. 113871. Date of Electronic Publication: 2021 Jan 22.
Typ publikacji :
Journal Article
MeSH Terms :
Antiviral Agents/*pharmacology
Antiviral Agents/*therapeutic use
COVID-19/*drug therapy
Drugs, Chinese Herbal/*pharmacology
Drugs, Chinese Herbal/*therapeutic use
Angiotensin-Converting Enzyme 2/metabolism ; Animals ; Antiviral Agents/chemistry ; Antiviral Agents/toxicity ; Cell Line, Transformed ; Chlorocebus aethiops ; Computational Biology ; Coronavirus 3C Proteases/metabolism ; Coronavirus Papain-Like Proteases/metabolism ; Cytokines/metabolism ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/toxicity ; Humans ; Medicine, Chinese Traditional/methods ; Molecular Docking Simulation ; Protein Array Analysis ; SARS-CoV-2/drug effects ; Signal Transduction/drug effects ; Vero Cells
SCR Protocol :
COVID-19 drug treatment
Czasopismo naukowe
Tytuł :
Centromeric chromatin integrity is compromised by loss of Cdk5rap2, a transcriptional activator of CENP-A.
Autorzy :
Wang X; Department of Biochemistry & Molecular Biology, Harbin Medical University, Harbin, China; Department of Cell Biology & Anatomy, Arnie Charbonneau Cancer and Alberta Children's Hospital Research Institutes, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Rosales JL; Department of Cell Biology & Anatomy, Arnie Charbonneau Cancer and Alberta Children's Hospital Research Institutes, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Gao X; Department of Biochemistry & Molecular Biology, Harbin Medical University, Harbin, China. Electronic address: .
Lee KY; Department of Cell Biology & Anatomy, Arnie Charbonneau Cancer and Alberta Children's Hospital Research Institutes, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. Electronic address: .
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Źródło :
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2021 Jun; Vol. 138, pp. 111463. Date of Electronic Publication: 2021 Mar 13.
Typ publikacji :
Journal Article
MeSH Terms :
Cell Cycle Proteins/*deficiency
Centromere/*metabolism
Centromere Protein A/*metabolism
Chromatin/*metabolism
Nerve Tissue Proteins/*deficiency
Transcriptional Activation/*physiology
Cell Cycle Proteins/genetics ; Cell Line, Transformed ; Cell Line, Tumor ; Centromere/genetics ; Centromere Protein A/genetics ; Chromatin/genetics ; Chromosome Segregation/physiology ; HEK293 Cells ; Humans ; Male ; Nerve Tissue Proteins/genetics ; Nucleosomes/genetics ; Nucleosomes/metabolism
Czasopismo naukowe
Tytuł :
Cobalt chloride-simulated hypoxia elongates primary cilia in immortalized human retina pigment epithelial-1 cells.
Autorzy :
Qiao Y; Key Laboratory of Regenerative Medicine, Ministry of Education, International Base of Collaboration for Science and Technology (JNU), The Ministry of Science and Technology & Guangdong Province, Department of Developmental and Regenerative Biology, Jinan University, Guangzhou, 510632, China.
Wang Z; Key Laboratory of Regenerative Medicine, Ministry of Education, International Base of Collaboration for Science and Technology (JNU), The Ministry of Science and Technology & Guangdong Province, Department of Developmental and Regenerative Biology, Jinan University, Guangzhou, 510632, China.
Bunikyte R; Key Laboratory of Regenerative Medicine, Ministry of Education, International Base of Collaboration for Science and Technology (JNU), The Ministry of Science and Technology & Guangdong Province, Department of Developmental and Regenerative Biology, Jinan University, Guangzhou, 510632, China.
Chen X; Key Laboratory of Regenerative Medicine, Ministry of Education, International Base of Collaboration for Science and Technology (JNU), The Ministry of Science and Technology & Guangdong Province, Department of Developmental and Regenerative Biology, Jinan University, Guangzhou, 510632, China.
Jin S; Key Laboratory of Regenerative Medicine, Ministry of Education, International Base of Collaboration for Science and Technology (JNU), The Ministry of Science and Technology & Guangdong Province, Department of Developmental and Regenerative Biology, Jinan University, Guangzhou, 510632, China.
Qi X; Key Laboratory of Regenerative Medicine, Ministry of Education, International Base of Collaboration for Science and Technology (JNU), The Ministry of Science and Technology & Guangdong Province, Department of Developmental and Regenerative Biology, Jinan University, Guangzhou, 510632, China.
Cai D; Key Laboratory of Regenerative Medicine, Ministry of Education, International Base of Collaboration for Science and Technology (JNU), The Ministry of Science and Technology & Guangdong Province, Department of Developmental and Regenerative Biology, Jinan University, Guangzhou, 510632, China. Electronic address: .
Feng S; Key Laboratory of Regenerative Medicine, Ministry of Education, International Base of Collaboration for Science and Technology (JNU), The Ministry of Science and Technology & Guangdong Province, Department of Developmental and Regenerative Biology, Jinan University, Guangzhou, 510632, China. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 May 28; Vol. 555, pp. 190-195. Date of Electronic Publication: 2021 Apr 03.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Hypoxia/*drug effects
Cilia/*drug effects
Cobalt/*toxicity
Retinal Pigment Epithelium/*cytology
Cell Hypoxia/physiology ; Cell Line, Transformed ; Cobalt/administration & dosage ; Dose-Response Relationship, Drug ; Down-Regulation/drug effects ; Humans ; Prolyl Hydroxylases/metabolism ; Retinal Pigment Epithelium/drug effects ; Telomerase/genetics ; Vesicular Transport Proteins/metabolism
Czasopismo naukowe
Tytuł :
The Effects of Insulin on Immortalized Rat Schwann Cells, IFRS1.
Autorzy :
Saiki T; Department of Pharmacy, Aichi Gakuin University Dental Hospital, Nagoya 464-8651, Japan.
Nakamura N; Department of Internal Medicine, School of Dentistry, Aichi Gakuin University, Nagoya 464-8651, Japan.
Miyabe M; Department of Internal Medicine, School of Dentistry, Aichi Gakuin University, Nagoya 464-8651, Japan.
Ito M; Department of Internal Medicine, School of Dentistry, Aichi Gakuin University, Nagoya 464-8651, Japan.
Minato T; Department of Clinical Laboratory, Aichi Gakuin University Dental Hospital, Nagoya 464-8651, Japan.
Sango K; Diabetic Neuropathy Project, Department of Diseases and Infection, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan.
Matsubara T; Department of Internal Medicine, School of Dentistry, Aichi Gakuin University, Nagoya 464-8651, Japan.
Naruse K; Department of Internal Medicine, School of Dentistry, Aichi Gakuin University, Nagoya 464-8651, Japan.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 May 23; Vol. 22 (11). Date of Electronic Publication: 2021 May 23.
Typ publikacji :
Journal Article
MeSH Terms :
Insulin/*pharmacology
Schwann Cells/*drug effects
Animals ; Cell Division/drug effects ; Cell Line, Transformed ; Chromones/pharmacology ; Diabetic Neuropathies/metabolism ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Flavonoids/pharmacology ; Gene Expression Regulation/drug effects ; Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors ; Morpholines/pharmacology ; Myelin Proteins/biosynthesis ; Myelin Proteins/genetics ; Phosphatidylinositol 3-Kinases/drug effects ; Phosphorylation ; Protein Processing, Post-Translational/drug effects ; Proto-Oncogene Proteins c-akt/metabolism ; Rats ; Rats, Inbred F344 ; Receptor, Insulin/biosynthesis ; Receptor, Insulin/genetics ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
Abrogation of IFN-γ Signaling May not Worsen Sensitivity to PD-1/PD-L1 Blockade.
Autorzy :
Vackova J; Department of Genetics and Microbiology, Faculty of Science, Charles University, BIOCEV, 252 50 Vestec, Czech Republic.; Department of Cell Biology, Faculty of Science, Charles University, BIOCEV, 252 50 Vestec, Czech Republic.
Piatakova A; Department of Genetics and Microbiology, Faculty of Science, Charles University, BIOCEV, 252 50 Vestec, Czech Republic.
Polakova I; Department of Genetics and Microbiology, Faculty of Science, Charles University, BIOCEV, 252 50 Vestec, Czech Republic.
Smahel M; Department of Genetics and Microbiology, Faculty of Science, Charles University, BIOCEV, 252 50 Vestec, Czech Republic.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2020 Mar 06; Vol. 21 (5). Date of Electronic Publication: 2020 Mar 06.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents, Immunological/*pharmacology
B7-H1 Antigen/*antagonists & inhibitors
Cell Line, Transformed/*drug effects
Interferon-gamma/*antagonists & inhibitors
Neoplasms, Experimental/*drug therapy
Programmed Cell Death 1 Receptor/*antagonists & inhibitors
Animals ; Cell Line, Transformed/immunology ; Cell Line, Transformed/metabolism ; Cell Line, Transformed/pathology ; Female ; Immunotherapy ; Mice ; Mice, Inbred C57BL ; Neoplasms, Experimental/immunology ; Neoplasms, Experimental/metabolism ; Neoplasms, Experimental/pathology ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Tauroursodeoxycholic acid attenuates cisplatin-induced ototoxicity by inhibiting the accumulation and aggregation of unfolded or misfolded proteins in the endoplasmic reticulum.
Autorzy :
Wen Y; Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Zong S; Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Liu T; Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Du P; Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Li H; Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Xiao H; Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. Electronic address: .
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Źródło :
Toxicology [Toxicology] 2021 Apr 15; Vol. 453, pp. 152736. Date of Electronic Publication: 2021 Feb 22.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cisplatin/*toxicity
Endoplasmic Reticulum/*drug effects
Ototoxicity/*prevention & control
Protein Aggregates/*drug effects
Protein Folding/*drug effects
Taurochenodeoxycholic Acid/*therapeutic use
Animals ; Antineoplastic Agents/toxicity ; Cell Line, Transformed ; Cell Survival/drug effects ; Cell Survival/physiology ; Dose-Response Relationship, Drug ; Endoplasmic Reticulum/pathology ; Hair Cells, Auditory/drug effects ; Hair Cells, Auditory/pathology ; Male ; Ototoxicity/pathology ; Protein Aggregates/physiology ; Rats ; Rats, Sprague-Dawley ; Taurochenodeoxycholic Acid/pharmacology
Czasopismo naukowe
Tytuł :
Melatonin- and Ferulic Acid-Based HDAC6 Selective Inhibitors Exhibit Pronounced Immunomodulatory Effects In Vitro and Neuroprotective Effects in a Pharmacological Alzheimer's Disease Mouse Model.
Autorzy :
He F; Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy and Food Chemistry, Julius Maximilian University of Würzburg, Am Hubland, Würzburg 97074, Germany.
Chou CJ; Department of Drug Discovery and Biomedical Sciences, South Carolina College of Pharmacy, Medical University of South Carolina, Charleston, South Carolina 29425, United States.
Scheiner M; Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy and Food Chemistry, Julius Maximilian University of Würzburg, Am Hubland, Würzburg 97074, Germany.
Poeta E; Department of Pharmacy and Biotechnologies, University of Bologna, Via Selmi 3, Bologna 40126, Italy.
Yuan Chen N; Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy and Food Chemistry, Julius Maximilian University of Würzburg, Am Hubland, Würzburg 97074, Germany.
Gunesch S; Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy and Food Chemistry, Julius Maximilian University of Würzburg, Am Hubland, Würzburg 97074, Germany.
Hoffmann M; Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy and Food Chemistry, Julius Maximilian University of Würzburg, Am Hubland, Würzburg 97074, Germany.
Sotriffer C; Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy and Food Chemistry, Julius Maximilian University of Würzburg, Am Hubland, Würzburg 97074, Germany.
Monti B; Department of Pharmacy and Biotechnologies, University of Bologna, Via Selmi 3, Bologna 40126, Italy.
Maurice T; MMDN, Univ Montpellier, EPHE, INSERM, Montpellier 34095, France.
Decker M; Pharmaceutical and Medicinal Chemistry, Institute of Pharmacy and Food Chemistry, Julius Maximilian University of Würzburg, Am Hubland, Würzburg 97074, Germany.
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Źródło :
Journal of medicinal chemistry [J Med Chem] 2021 Apr 08; Vol. 64 (7), pp. 3794-3812. Date of Electronic Publication: 2021 Mar 26.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Alzheimer Disease/*drug therapy
Coumaric Acids/*therapeutic use
Histone Deacetylase 6/*antagonists & inhibitors
Immunologic Factors/*therapeutic use
Neuroprotective Agents/*therapeutic use
Tryptamines/*therapeutic use
Alzheimer Disease/enzymology ; Alzheimer Disease/metabolism ; Animals ; Catalytic Domain ; Cell Line, Transformed ; Coumaric Acids/chemical synthesis ; Coumaric Acids/metabolism ; Histone Deacetylase 6/chemistry ; Histone Deacetylase 6/metabolism ; Histone Deacetylase Inhibitors/chemical synthesis ; Histone Deacetylase Inhibitors/metabolism ; Histone Deacetylase Inhibitors/therapeutic use ; Immunologic Factors/chemical synthesis ; Immunologic Factors/metabolism ; Male ; Melatonin/analogs & derivatives ; Melatonin/metabolism ; Melatonin/therapeutic use ; Mice ; Molecular Docking Simulation ; Neuroprotective Agents/chemical synthesis ; Neuroprotective Agents/metabolism ; Structure-Activity Relationship ; Tryptamines/chemical synthesis ; Tryptamines/metabolism
Czasopismo naukowe
Tytuł :
hTERT-Driven Immortalization of RDEB Fibroblast and Keratinocyte Cell Lines Followed by Cre-Mediated Transgene Elimination.
Autorzy :
Evtushenko NA; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, Ostrovityanova 1, 117997 Moscow, Russia.
Beilin AK; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, Ostrovityanova 1, 117997 Moscow, Russia.; Koltzov Institute of Developmental Biology of Russian Academy of Sciences, 26 Vavilova Str., 119334 Moscow, Russia.
Dashinimaev EB; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, Ostrovityanova 1, 117997 Moscow, Russia.; Koltzov Institute of Developmental Biology of Russian Academy of Sciences, 26 Vavilova Str., 119334 Moscow, Russia.
Ziganshin RH; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia.
Kosykh AV; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, Ostrovityanova 1, 117997 Moscow, Russia.; Koltzov Institute of Developmental Biology of Russian Academy of Sciences, 26 Vavilova Str., 119334 Moscow, Russia.
Perfilov MM; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia.
Rippa AL; Koltzov Institute of Developmental Biology of Russian Academy of Sciences, 26 Vavilova Str., 119334 Moscow, Russia.
Alpeeva EV; Koltzov Institute of Developmental Biology of Russian Academy of Sciences, 26 Vavilova Str., 119334 Moscow, Russia.
Vasiliev AV; Koltzov Institute of Developmental Biology of Russian Academy of Sciences, 26 Vavilova Str., 119334 Moscow, Russia.
Vorotelyak EA; Koltzov Institute of Developmental Biology of Russian Academy of Sciences, 26 Vavilova Str., 119334 Moscow, Russia.
Gurskaya NG; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, Ostrovityanova 1, 117997 Moscow, Russia.; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Miklukho-Maklaya 16/10, 117997 Moscow, Russia.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Apr 07; Vol. 22 (8). Date of Electronic Publication: 2021 Apr 07.
Typ publikacji :
Journal Article
MeSH Terms :
Homologous Recombination*
Transgenes*
Fibroblasts/*metabolism
Integrases/*metabolism
Keratinocytes/*metabolism
Telomerase/*genetics
Adolescent ; Adult ; Biomarkers ; Cell Line, Transformed ; Cell Proliferation ; Cellular Senescence/genetics ; Child ; Epidermolysis Bullosa Dystrophica/etiology ; Epidermolysis Bullosa Dystrophica/metabolism ; Female ; Fibroblasts/pathology ; Fluorescent Antibody Technique ; Gene Knockdown Techniques ; Gene Order ; Genetic Vectors/genetics ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Mutation ; Polycomb Repressive Complex 1/genetics ; Polycomb Repressive Complex 1/metabolism ; Primary Cell Culture ; Proteomics/methods ; Telomerase/metabolism ; Young Adult
Czasopismo naukowe
Tytuł :
Kellerin from Ferula sinkiangensis exerts neuroprotective effects after focal cerebral ischemia in rats by inhibiting microglia-mediated inflammatory responses.
Autorzy :
Mi Y; College of Life and Health Sciences, Northeastern University, Shenyang, China; Key Laboratory of Data Analytics and Optimization for Smart Industry, Northeastern University, Ministry of Education, Shenyang, China.
Jiao K; College of Life and Health Sciences, Northeastern University, Shenyang, China; Key Laboratory of Data Analytics and Optimization for Smart Industry, Northeastern University, Ministry of Education, Shenyang, China.
Xu JK; College of Life and Health Sciences, Northeastern University, Shenyang, China; Key Laboratory of Data Analytics and Optimization for Smart Industry, Northeastern University, Ministry of Education, Shenyang, China.
Wei K; School of Chemical Science and Technology, Yunnan University, Kunming, China.
Liu JY; College of Life and Health Sciences, Northeastern University, Shenyang, China.
Meng QQ; College of Life and Health Sciences, Northeastern University, Shenyang, China.
Guo TT; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.
Zhang XN; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.
Zhou D; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.
Qing DG; XinJiang Institute of Chinese Materia Medica and Ethnodrug, Urumqi, China.
Sun Y; XinJiang Institute of Chinese Materia Medica and Ethnodrug, Urumqi, China.
Li N; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China. Electronic address: .
Hou Y; College of Life and Health Sciences, Northeastern University, Shenyang, China; Key Laboratory of Data Analytics and Optimization for Smart Industry, Northeastern University, Ministry of Education, Shenyang, China. Electronic address: .
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Źródło :
Journal of ethnopharmacology [J Ethnopharmacol] 2021 Apr 06; Vol. 269, pp. 113718. Date of Electronic Publication: 2020 Dec 25.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Inflammatory Agents/*pharmacology
Brain Ischemia/*drug therapy
Ferula/*chemistry
Infarction, Middle Cerebral Artery/*drug therapy
Neuroprotective Agents/*pharmacology
Plant Extracts/*pharmacology
Animals ; Anti-Inflammatory Agents/therapeutic use ; Brain Edema/drug therapy ; Brain Ischemia/etiology ; Brain Ischemia/pathology ; Cell Line, Transformed ; Cell Line, Tumor ; Cytokines/metabolism ; Disease Models, Animal ; Humans ; Infarction, Middle Cerebral Artery/etiology ; Infarction, Middle Cerebral Artery/pathology ; Inflammation/drug therapy ; Lipopolysaccharides/toxicity ; Mice ; Microglia/drug effects ; Microglia/pathology ; NADPH Oxidases/antagonists & inhibitors ; NF-kappa B p50 Subunit/antagonists & inhibitors ; Neurons/drug effects ; Neuroprotective Agents/therapeutic use ; Plant Extracts/therapeutic use ; Rats, Sprague-Dawley ; Reactive Oxygen Species/metabolism ; Signal Transduction/drug effects
Czasopismo naukowe
Tytuł :
CYT387, a Novel JAK2 Inhibitor, Suppresses IL-13-Induced Epidermal Barrier Dysfunction Via miR-143 Targeting IL-13Rα1 and STAT3.
Autorzy :
Zu Y; School of Mechanical and Material Engineering, North China University of Technology, No. 5 Jinyuanzhuang Road, Shijingshan District, Beijing, 100144, People's Republic of China. .
Chen XF; Beijing Institute of Astronautical System Engineering, Beijing, 10076, People's Republic of China.
Li Q; School of Mechanical and Material Engineering, North China University of Technology, No. 5 Jinyuanzhuang Road, Shijingshan District, Beijing, 100144, People's Republic of China.
Zhang ST; School of Mechanical and Material Engineering, North China University of Technology, No. 5 Jinyuanzhuang Road, Shijingshan District, Beijing, 100144, People's Republic of China.
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Źródło :
Biochemical genetics [Biochem Genet] 2021 Apr; Vol. 59 (2), pp. 531-546. Date of Electronic Publication: 2020 Nov 15.
Typ publikacji :
Journal Article
MeSH Terms :
Benzamides/*pharmacology
Epidermis/*metabolism
Interleukin-13/*metabolism
Interleukin-13 Receptor alpha1 Subunit/*metabolism
Janus Kinase 2/*antagonists & inhibitors
MicroRNAs/*metabolism
Pyrimidines/*pharmacology
STAT3 Transcription Factor/*metabolism
Cell Line, Transformed ; Dermatitis, Atopic/genetics ; Dermatitis, Atopic/metabolism ; Dermatitis, Atopic/pathology ; Epidermis/pathology ; Humans ; Interleukin-13/genetics ; Interleukin-13 Receptor alpha1 Subunit/genetics ; Janus Kinase 2/genetics ; Janus Kinase 2/metabolism ; MicroRNAs/genetics ; STAT3 Transcription Factor/genetics
Czasopismo naukowe
Tytuł :
Protective effect of the sphingosine-1 phosphate receptor agonist siponimod on disrupted blood brain barrier function.
Autorzy :
Spampinato SF; Department of Biomedical and Biotechnological Sciences, Section of Pharmacology, Catania, Italy.
Merlo S; Department of Biomedical and Biotechnological Sciences, Section of Pharmacology, Catania, Italy.
Sano Y; Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan.
Kanda T; Department of Neurology and Clinical Neuroscience, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan.
Sortino MA; Department of Biomedical and Biotechnological Sciences, Section of Pharmacology, Catania, Italy. Electronic address: .
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Źródło :
Biochemical pharmacology [Biochem Pharmacol] 2021 Apr; Vol. 186, pp. 114465. Date of Electronic Publication: 2021 Feb 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Azetidines/*pharmacology
Benzyl Compounds/*pharmacology
Blood-Brain Barrier/*drug effects
Neuroprotective Agents/*pharmacology
Sphingosine 1 Phosphate Receptor Modulators/*pharmacology
Sphingosine-1-Phosphate Receptors/*agonists
Blood-Brain Barrier/cytology ; Blood-Brain Barrier/metabolism ; Cell Line, Transformed ; Coculture Techniques ; Endothelium, Vascular/cytology ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/metabolism ; Humans ; Sphingosine-1-Phosphate Receptors/metabolism
Czasopismo naukowe
Tytuł :
MSC exosome-mediated cardioprotection in ischemic mouse heart comparative proteomics of infarct and peri-infarct areas.
Autorzy :
Kore RA; Department of Medicine, Cardiology Division, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA. .; Central Arkansas Veterans Healthcare System, Little Rock, AR, 72205, USA. .
Wang X; Henan Key Laboratory of Medical Tissue Regeneration, Xinxiang Medical University, Xinxiang, 453003, China.
Ding Z; Department of Medicine, Cardiology Division, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.; Central Arkansas Veterans Healthcare System, Little Rock, AR, 72205, USA.
Griffin RJ; Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.
Tackett AJ; Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.
Mehta JL; Department of Medicine, Cardiology Division, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA.; Central Arkansas Veterans Healthcare System, Little Rock, AR, 72205, USA.
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Źródło :
Molecular and cellular biochemistry [Mol Cell Biochem] 2021 Apr; Vol. 476 (4), pp. 1691-1704. Date of Electronic Publication: 2021 Jan 10.
Typ publikacji :
Journal Article
MeSH Terms :
Exosomes*/metabolism
Exosomes*/pathology
Exosomes*/transplantation
Myocardial Infarction*/metabolism
Myocardial Infarction*/pathology
Myocardial Infarction*/prevention & control
Mesenchymal Stem Cells/*metabolism
Animals ; Cell Line, Transformed ; Humans ; Male ; Mesenchymal Stem Cells/pathology ; Mice
Czasopismo naukowe
Tytuł :
Knockdown of TRAF6 inhibits chondrocytes apoptosis and inflammation by suppressing the NF-κB pathway in lumbar facet joint osteoarthritis.
Autorzy :
Jiang J; Department of Spine Surgery, Affiliated Hospital 2 of Nantong University, Nantong, 226001, Jiangsu, China.
Zhang J; Department of Spine Surgery, Affiliated Hospital 2 of Nantong University, Nantong, 226001, Jiangsu, China.
Wu C; Department of Spine Surgery, Affiliated Hospital 2 of Nantong University, Nantong, 226001, Jiangsu, China.
Chen C; Department of Spine Surgery, Affiliated Hospital 2 of Nantong University, Nantong, 226001, Jiangsu, China.
Bao G; Department of Spine Surgery, Affiliated Hospital 2 of Nantong University, Nantong, 226001, Jiangsu, China.
Xu G; Department of Spine Surgery, Affiliated Hospital 2 of Nantong University, Nantong, 226001, Jiangsu, China.
Xue P; Department of Spine Surgery, Affiliated Hospital 2 of Nantong University, Nantong, 226001, Jiangsu, China.
Zhou Y; Department of Spine Surgery, Affiliated Hospital 2 of Nantong University, Nantong, 226001, Jiangsu, China.
Sun Y; Department of Orthopedic, Nantong Third People's Hospital of Nantong University, Nantong, 226001, Jiangsu, China. .
Cui Z; Department of Spine Surgery, Affiliated Hospital 2 of Nantong University, Nantong, 226001, Jiangsu, China. .
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Źródło :
Molecular and cellular biochemistry [Mol Cell Biochem] 2021 Apr; Vol. 476 (4), pp. 1929-1938. Date of Electronic Publication: 2021 Jan 27.
Typ publikacji :
Journal Article
MeSH Terms :
Apoptosis*
Signal Transduction*
Chondrocytes/*metabolism
Intracellular Signaling Peptides and Proteins/*deficiency
Osteoarthritis, Spine/*metabolism
Transcription Factor RelA/*metabolism
Zygapophyseal Joint/*metabolism
Cell Line, Transformed ; Chondrocytes/pathology ; Gene Knockdown Techniques ; Humans ; Intracellular Signaling Peptides and Proteins/metabolism ; Osteoarthritis, Spine/genetics ; Osteoarthritis, Spine/pathology ; Transcription Factor RelA/genetics ; Zygapophyseal Joint/pathology
Czasopismo naukowe
Tytuł :
Increased production of matrix metalloproteinase-7 (MMP-7) by asbestos exposure enhances tissue migration of human regulatory T-like cells.
Autorzy :
Lee S; Department of Hygiene, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan. Electronic address: .
Yamamoto S; Department of Hygiene, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan. Electronic address: .
Srinivas B; Department of Hygiene, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan. Electronic address: .
Shimizu Y; Department of Hygiene, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan; Department of Pathophysiology-Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 700-8558, Japan. Electronic address: .
Sada N; Department of Hygiene, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan; Department of Biophysical Chemistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, 700-8530, Okayama, Japan. Electronic address: .
Yoshitome K; Department of Hygiene, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan. Electronic address: .
Ito T; Department of Hygiene, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan. Electronic address: .
Kumagai-Takei N; Department of Hygiene, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan. Electronic address: .
Nishimura Y; Department of Hygiene, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan. Electronic address: .
Otsuki T; Department of Hygiene, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan. Electronic address: .
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Źródło :
Toxicology [Toxicology] 2021 Mar 30; Vol. 452, pp. 152717. Date of Electronic Publication: 2021 Feb 10.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Asbestos/*toxicity
Carcinogens/*toxicity
Cell Movement/*drug effects
Matrix Metalloproteinase 7/*biosynthesis
T-Lymphocytes, Regulatory/*drug effects
T-Lymphocytes, Regulatory/*metabolism
Cell Line, Transformed ; Cell Movement/physiology ; Humans
Czasopismo naukowe
Tytuł :
Stabilization of C/EBPβ through direct interaction with STAT3 in H-Ras transformed human mammary epithelial cells.
Autorzy :
Lee LL; Tumor Microenvironment Global Core Research Center, College of Pharmacy, Seoul National University, Seoul, 08826, South Korea.
Kim SJ; Tumor Microenvironment Global Core Research Center, College of Pharmacy, Seoul National University, Seoul, 08826, South Korea.
Hahn YI; Tumor Microenvironment Global Core Research Center, College of Pharmacy, Seoul National University, Seoul, 08826, South Korea; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, 08826, South Korea.
Jang JH; Tumor Microenvironment Global Core Research Center, College of Pharmacy, Seoul National University, Seoul, 08826, South Korea.
Saeidi S; Tumor Microenvironment Global Core Research Center, College of Pharmacy, Seoul National University, Seoul, 08826, South Korea; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, 08826, South Korea.
Surh YJ; Tumor Microenvironment Global Core Research Center, College of Pharmacy, Seoul National University, Seoul, 08826, South Korea; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, 08826, South Korea; Cancer Research Institute, Seoul National University, Seoul, 03080, South Korea. Electronic address: .
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Źródło :
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Mar 26; Vol. 546, pp. 130-137. Date of Electronic Publication: 2021 Feb 11.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cell Transformation, Neoplastic*
Genes, ras*
Breast/*pathology
CCAAT-Enhancer-Binding Protein-beta/*metabolism
Epithelial Cells/*pathology
STAT3 Transcription Factor/*metabolism
Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; CCAAT-Enhancer-Binding Protein-beta/antagonists & inhibitors ; Cell Line, Transformed ; Feedback, Physiological ; Female ; Granulocyte Colony-Stimulating Factor/metabolism ; Granulocyte-Macrophage Colony-Stimulating Factor/metabolism ; Humans ; Inflammation/metabolism ; Inflammation/pathology ; Interleukin-8/metabolism ; Neutrophils/cytology ; Proteasome Endopeptidase Complex/metabolism ; Protein Binding ; Protein Stability ; Signal Transduction ; Ubiquitination
Czasopismo naukowe
Tytuł :
Ginkgo Biloba Extract EGB761 Ameliorates the Extracellular Matrix Accumulation and Mesenchymal Transformation of Renal Tubules in Diabetic Kidney Disease by Inhibiting Endoplasmic Reticulum Stress.
Autorzy :
Han J; Henan University of Chinese Medicine, Zhengzhou, 450046 Henan, China.
Pang X; Department of Nephropathy, Henan Provincial Hospital of Traditional Chinese Medicine/The Second Hospital Affiliated to Henan University of Chinese Medicine, Zhengzhou, 450002 Henan, China.
Shi X; Henan University of Chinese Medicine, Zhengzhou, 450046 Henan, China.
Zhang Y; Henan University of Chinese Medicine, Zhengzhou, 450046 Henan, China.
Peng Z; Henan University of Chinese Medicine, Zhengzhou, 450046 Henan, China.
Xing Y; Henan University of Chinese Medicine, Zhengzhou, 450046 Henan, China.
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Źródło :
BioMed research international [Biomed Res Int] 2021 Mar 23; Vol. 2021, pp. 6657206. Date of Electronic Publication: 2021 Mar 23 (Print Publication: 2021).
Typ publikacji :
Journal Article
MeSH Terms :
Endoplasmic Reticulum Stress*/drug effects
Diabetic Nephropathies/*drug therapy
Extracellular Matrix/*metabolism
Mesoderm/*pathology
Plant Extracts/*therapeutic use
Animals ; Cell Line ; Cell Line, Transformed ; Diabetic Nephropathies/pathology ; Diabetic Nephropathies/physiopathology ; Epithelial-Mesenchymal Transition/drug effects ; Extracellular Matrix/drug effects ; Extracellular Matrix/ultrastructure ; Humans ; Kidney Tubules/drug effects ; Kidney Tubules/injuries ; Kidney Tubules/physiopathology ; Kidney Tubules/ultrastructure ; Male ; Mesoderm/drug effects ; Mice, Inbred C57BL ; Plant Extracts/pharmacology ; Retinol-Binding Proteins, Plasma/urine ; beta 2-Microglobulin/urine
Czasopismo naukowe
Tytuł :
Molecular Alterations in Sporadic and SOD1 -ALS Immortalized Lymphocytes: Towards a Personalized Therapy.
Autorzy :
Lastres-Becker I; Instituto de Investigaciones Biomédicas 'Alberto Sols' UAM-CSIC, Arturo Duperier 4, 28029 Madrid, Spain.; Department of Biochemistry, School of Medicine, Universidad Autónoma de Madrid, Arturo Duperier 4, 28029 Madrid, Spain.; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, 28031 Madrid, Spain.; Institute Teófilo Hernando for Drug Discovery, Universidad Autónoma de Madrid, 28029 Madrid, Spain.
Porras G; Centro de Investigaciones Biológicas-CSIC, Avd, Ramiro Maetzu 9, 28031 Madrid, Spain.
Arribas-Blázquez M; Instituto de Investigaciones Biomédicas 'Alberto Sols' UAM-CSIC, Arturo Duperier 4, 28029 Madrid, Spain.; Department of Biochemistry, School of Medicine, Universidad Autónoma de Madrid, Arturo Duperier 4, 28029 Madrid, Spain.; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, 28031 Madrid, Spain.
Maestro I; Centro de Investigaciones Biológicas-CSIC, Avd, Ramiro Maetzu 9, 28031 Madrid, Spain.
Borrego-Hernández D; ALS Unit, Hospital 12 de Octubre Research Institute (i+12), 28041 Madrid, Spain.
Boya P; Centro de Investigaciones Biológicas-CSIC, Avd, Ramiro Maetzu 9, 28031 Madrid, Spain.
Cerdán S; Instituto de Investigaciones Biomédicas 'Alberto Sols' UAM-CSIC, Arturo Duperier 4, 28029 Madrid, Spain.
García-Redondo A; ALS Unit, Hospital 12 de Octubre Research Institute (i+12), 28041 Madrid, Spain.; Centro de Investigación Biomédica en Red Sobre Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Martínez A; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, 28031 Madrid, Spain.; Centro de Investigaciones Biológicas-CSIC, Avd, Ramiro Maetzu 9, 28031 Madrid, Spain.
Martin-Requero Á; Centro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, 28031 Madrid, Spain.; Centro de Investigaciones Biológicas-CSIC, Avd, Ramiro Maetzu 9, 28031 Madrid, Spain.
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Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 16; Vol. 22 (6). Date of Electronic Publication: 2021 Mar 16.
Typ publikacji :
Journal Article
MeSH Terms :
Precision Medicine*
Amyotrophic Lateral Sclerosis/*enzymology
Amyotrophic Lateral Sclerosis/*immunology
Lymphocytes/*immunology
Mutation/*genetics
Superoxide Dismutase-1/*genetics
Acids/metabolism ; Aged ; Aged, 80 and over ; Amyotrophic Lateral Sclerosis/genetics ; Autophagy/genetics ; Cell Line, Transformed ; Energy Metabolism ; Female ; Heterozygote ; Humans ; Magnetic Resonance Spectroscopy ; Male ; Metabolomics ; Middle Aged ; NF-E2-Related Factor 2/metabolism ; Oxidative Stress ; Oxygen Consumption ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Reactive Oxygen Species/metabolism ; Signal Transduction ; Superoxide Dismutase-1/metabolism ; Thiobarbituric Acid Reactive Substances/metabolism
Czasopismo naukowe
Tytuł :
Metabolic Glycoengineering in hMSC-TERT as a Model for Skeletal Precursors by Using Modified Azide/Alkyne Monosaccharides.
Autorzy :
Altmann S; Bernhard-Heine-Center for Locomotion Research, University of Würzburg, Friedrich-Bergius-Ring 15, 97076 Würzburg, Germany.
Mut J; Institute of Organic Chemistry, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.
Wolf N; Institute of Organic Chemistry, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.
Meißner-Weigl J; Bernhard-Heine-Center for Locomotion Research, University of Würzburg, Friedrich-Bergius-Ring 15, 97076 Würzburg, Germany.
Rudert M; Bernhard-Heine-Center for Locomotion Research, University of Würzburg, Friedrich-Bergius-Ring 15, 97076 Würzburg, Germany.
Jakob F; Bernhard-Heine-Center for Locomotion Research, University of Würzburg, Friedrich-Bergius-Ring 15, 97076 Würzburg, Germany.
Gutmann M; Institute of Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.
Lühmann T; Institute of Pharmacy and Food Chemistry, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.
Seibel J; Institute of Organic Chemistry, University of Würzburg, Am Hubland, 97074 Würzburg, Germany.
Ebert R; Bernhard-Heine-Center for Locomotion Research, University of Würzburg, Friedrich-Bergius-Ring 15, 97076 Würzburg, Germany.
Pokaż więcej
Źródło :
International journal of molecular sciences [Int J Mol Sci] 2021 Mar 10; Vol. 22 (6). Date of Electronic Publication: 2021 Mar 10.
Typ publikacji :
Journal Article
MeSH Terms :
Glycocalyx*/chemistry
Glycocalyx*/metabolism
Hexosamines*/chemistry
Hexosamines*/metabolism
Metabolic Engineering*
Models, Biological*
Mesenchymal Stem Cells/*metabolism
Myoblasts, Skeletal/*metabolism
Cell Line, Transformed ; Humans
Czasopismo naukowe

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