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Tytuł:
Comparative Analysis of Primary Ovarian Cancer Cells and Established Cell Lines as a New Tool for Studies on Ovarian Cancer Cell Complexity.
Autorzy:
Szyposzynska A; Laboratory of Biology of Stem and Neoplastic Cells, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland.
Bielawska-Pohl A; Laboratory of Biology of Stem and Neoplastic Cells, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland.
Paprocka M; Laboratory of Biology of Stem and Neoplastic Cells, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland.
Bar J; Department of Immunopathology and Molecular Biology, Wroclaw Medical University, 50-556 Wroclaw, Poland.
Murawski M; 1st Department of Gynecology and Obstetrics, Wroclaw Medical University, 50-599 Wroclaw, Poland.
Klimczak A; Laboratory of Biology of Stem and Neoplastic Cells, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, 53-114 Wroclaw, Poland.
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Źródło:
International journal of molecular sciences [Int J Mol Sci] 2024 May 15; Vol. 25 (10). Date of Electronic Publication: 2024 May 15.
Typ publikacji:
Journal Article; Comparative Study
MeSH Terms:
Ovarian Neoplasms*/metabolism
Ovarian Neoplasms*/pathology
Tumor Cells, Cultured*
Cell Line, Tumor*
Female ; Neoplastic Stem Cells/metabolism ; Flow Cytometry ; Fluorescent Antibody Technique ; PAX8 Transcription Factor/analysis ; Telomerase ; Cell Movement ; Aldehyde Dehydrogenase 1 Family
Czasopismo naukowe
Pełny tekst  Link otwiera się w nowym oknie Pełny tekstSzczegóły
Tytuł:
Statistical Assessment of Drug Synergy from In Vivo Combination Studies Using Mouse Tumor Models.
Autorzy:
Mao B; Crown Bioscience Inc., Suzhou, Jiangsu, P.R. China.
Guo S; Crown Bioscience Inc., Suzhou, Jiangsu, P.R. China.
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Źródło:
Cancer research communications [Cancer Res Commun] 2023 Oct 23; Vol. 3 (10), pp. 2146-2157.
Typ publikacji:
Journal Article
MeSH Terms:
Cell Line, Tumor*
Animals ; Mice ; Humans ; Disease Models, Animal ; Drug Therapy, Combination
Czasopismo naukowe
Full Text Finder  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Label-free tumor cells classification using deep learning and high-content imaging.
Autorzy:
Piansaddhayanon C; Department of Computer Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok, 10330, Thailand.; Center of Excellence in Computational Molecular Biology, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.; Chula Intelligent and Complex Systems, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.
Koracharkornradt C; Center of Excellence in Computational Molecular Biology, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.
Laosaengpha N; Department of Computer Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok, 10330, Thailand.; Center of Excellence in Computational Molecular Biology, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.
Tao Q; NVIDIA AI Technology Center, Singapore, Singapore.
Ingrungruanglert P; Center of Excellence for Stem Cell and Cell Therapy, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.
Israsena N; Center of Excellence for Stem Cell and Cell Therapy, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand. .; Department of Pharmacology, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand. .
Chuangsuwanich E; Department of Computer Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok, 10330, Thailand. .; Center of Excellence in Computational Molecular Biology, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand. .
Sriswasdi S; Center of Excellence in Computational Molecular Biology, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand. .; Center for Artificial Intelligence in Medicine, Research Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand. .
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Źródło:
Scientific data [Sci Data] 2023 Aug 26; Vol. 10 (1), pp. 570. Date of Electronic Publication: 2023 Aug 26.
Typ publikacji:
Dataset; Journal Article
MeSH Terms:
Cell Line, Tumor*/classification
Cell Line, Tumor*/pathology
Neoplasms*/diagnostic imaging
Neoplasms*/pathology
Humans ; Area Under Curve ; Deep Learning ; Microscopy
Czasopismo naukowe
Full Text Finder  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Downregulation of ATP5F1D inhibits mtROS/NLRP3/caspase-1/GSDMD axis to suppress pyroptosis-mediated malignant progression of endometrial cancer.
Autorzy:
Cheng Y; The First Clinical Medical College of Lanzhou University, Department of Obstetrics and Gynecology, Gansu Provincial Clinical Research Center for Gynecological Oncology, Lanzhou 730000, Gansu, China; Department of Obstetrics and Gynecology, the First Hospital of Lanzhou University, Gansu Provincial Clinical Research Center for Gynecological Oncology, Lanzhou 730000, Gansu, China.
Chen X; The First Clinical Medical College of Lanzhou University, Department of Obstetrics and Gynecology, Gansu Provincial Clinical Research Center for Gynecological Oncology, Lanzhou 730000, Gansu, China.
Hu D; The First Clinical Medical College of Lanzhou University, Department of Obstetrics and Gynecology, Gansu Provincial Clinical Research Center for Gynecological Oncology, Lanzhou 730000, Gansu, China.
Du J; The First Clinical Medical College of Lanzhou University, Department of Obstetrics and Gynecology, Gansu Provincial Clinical Research Center for Gynecological Oncology, Lanzhou 730000, Gansu, China.
Xing Y; The First Clinical Medical College of Lanzhou University, Department of Obstetrics and Gynecology, Gansu Provincial Clinical Research Center for Gynecological Oncology, Lanzhou 730000, Gansu, China.
Liang X; Department of Obstetrics and Gynecology, the First Hospital of Lanzhou University, Gansu Provincial Clinical Research Center for Gynecological Oncology, Lanzhou 730000, Gansu, China.
Yang Y; Department of Obstetrics and Gynecology, the First Hospital of Lanzhou University, Gansu Provincial Clinical Research Center for Gynecological Oncology, Lanzhou 730000, Gansu, China. Electronic address: .
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Źródło:
International immunopharmacology [Int Immunopharmacol] 2024 Sep 30; Vol. 139, pp. 112808. Date of Electronic Publication: 2024 Jul 28.
Typ publikacji:
Journal Article
MeSH Terms:
Endometrial Neoplasms*/pathology
Endometrial Neoplasms*/metabolism
Endometrial Neoplasms*/genetics
NLR Family, Pyrin Domain-Containing 3 Protein*/metabolism
NLR Family, Pyrin Domain-Containing 3 Protein*/genetics
Pyroptosis*
Mice, Nude*
Caspase 1*/metabolism
Mitochondrial Proton-Translocating ATPases*/metabolism
Mitochondrial Proton-Translocating ATPases*/genetics
Humans ; Female ; Animals ; Cell Line, Tumor ; Mice ; Down-Regulation ; Disease Progression ; Mice, Inbred BALB C ; Mitochondria/metabolism ; Signal Transduction ; Reactive Oxygen Species/metabolism ; Gene Expression Regulation, Neoplastic ; Gasdermins ; Phosphate-Binding Proteins
Czasopismo naukowe
Full Text Finder  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Identification and validation of the prognostic signature of a novel demethylation-related gene associated with the clinical features of colon cancer.
Autorzy:
Kang K; Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; The Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Huang H; Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; The Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Chen Z; Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; The Hunan Provincial Key Lab of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China. Electronic address: .
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Źródło:
International immunopharmacology [Int Immunopharmacol] 2024 Sep 30; Vol. 139, pp. 112798. Date of Electronic Publication: 2024 Jul 29.
Typ publikacji:
Journal Article; Validation Study
MeSH Terms:
Colonic Neoplasms*/genetics
Colonic Neoplasms*/mortality
Colonic Neoplasms*/pathology
Colonic Neoplasms*/diagnosis
Gene Expression Regulation, Neoplastic*
Mice, Nude*
Biomarkers, Tumor*/genetics
Humans ; Animals ; Prognosis ; Male ; Female ; Mice ; Cell Line, Tumor ; Demethylation ; Nomograms ; Middle Aged ; DNA Methylation ; Mice, Inbred BALB C ; Aged
Czasopismo naukowe
Full Text Finder  Link otwiera się w nowym oknieSzczegóły
Tytuł:
LPCAT2-mediated lipid droplet production supports pancreatic cancer chemoresistance and cell motility.
Autorzy:
Lin Y; Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, PR China. Electronic address: .
Zhang X; Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, PR China. Electronic address: .
Wang Y; Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, PR China. Electronic address: .
Yao W; Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, PR China. Electronic address: .
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Źródło:
International immunopharmacology [Int Immunopharmacol] 2024 Sep 30; Vol. 139, pp. 112681. Date of Electronic Publication: 2024 Jul 27.
Typ publikacji:
Journal Article
MeSH Terms:
Cell Movement*/drug effects
Pancreatic Neoplasms*/drug therapy
Pancreatic Neoplasms*/metabolism
Pancreatic Neoplasms*/pathology
Drug Resistance, Neoplasm*
1-Acylglycerophosphocholine O-Acyltransferase*/metabolism
1-Acylglycerophosphocholine O-Acyltransferase*/genetics
Lipid Droplets*/metabolism
Deoxycytidine*/analogs & derivatives
Deoxycytidine*/pharmacology
Deoxycytidine*/therapeutic use
Gemcitabine*
Humans ; Animals ; Cell Line, Tumor ; Mice ; Male ; Female ; Mice, Nude ; Xenograft Model Antitumor Assays ; STAT5 Transcription Factor/metabolism ; Middle Aged ; Mice, Inbred BALB C ; Gene Expression Regulation, Neoplastic/drug effects ; Cell Proliferation/drug effects
Czasopismo naukowe
Full Text Finder  Link otwiera się w nowym oknieSzczegóły
Tytuł:
RNA modification Regulators' Co-Expression Score (RMRCoeS) predicts biochemical recurrence and therapy response in prostate cancer: A multi-omics and experimental validation study.
Autorzy:
Cai Z; Department of Andrology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, China.
Jiang Z; Department of Andrology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, China; Department of Oncology, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, 510700, Guangzhou, China; The Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, 510700, Guangzhou, China.
Li S; Department of Andrology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, China; Department of Urology, The Second People's Hospital of Guangxi Zhuang Autonomous Region, Guilin, Guangxi 541002, China.
Mo S; Department of Andrology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, China.
Wang S; Department of Urology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510282, China.
Liang M; Department of Oncology, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, 510700, Guangzhou, China; The Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, 510700, Guangzhou, China.
Tan X; Department of Urology, School of Clinical Medicine, The Affiliated Hospital of Southwest Medical University, Southwest Medical University, Luzhou 646000, Sichuan, China.
Zhong W; Department of Urology, Guangdong Key Laboratory of Clinical Molecular Medicine and Diagnostics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, China; State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa 999078, Macau.
Zhang L; Institute for Integrative Genome Biology, University of California, Riverside 92507, CA, USA.
Deng J; Department of Andrology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, China. Electronic address: .
Zhong C; Department of Andrology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, China. Electronic address: .
Lu J; Department of Andrology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, China; Department of Urology, Guangdong Key Laboratory of Clinical Molecular Medicine and Diagnostics, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, China. Electronic address: .
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Źródło:
International immunopharmacology [Int Immunopharmacol] 2024 Sep 30; Vol. 139, pp. 112723. Date of Electronic Publication: 2024 Jul 24.
Typ publikacji:
Journal Article; Validation Study
MeSH Terms:
Prostatic Neoplasms*/genetics
Prostatic Neoplasms*/therapy
Prostatic Neoplasms*/metabolism
Prostatic Neoplasms*/pathology
Gene Expression Regulation, Neoplastic*
Neoplasm Recurrence, Local*/genetics
Humans ; Male ; Prognosis ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; RNA/genetics ; RNA/metabolism ; Cell Line, Tumor ; Mutation ; Immunotherapy/methods ; Precision Medicine ; Multiomics
Czasopismo naukowe
Full Text Finder  Link otwiera się w nowym oknieSzczegóły
Tytuł:
M2 macrophage exosomes promote resistance to sorafenib in hepatocellular carcinoma cells via miR-200c-3p.
Autorzy:
Li W; Shihezi University School of Medicine, Shihezi 832000, China; Key Laboratory for Prevention and Treatment of High Morbidity in Central Asia, National Health and Health Commission, Shihezi 832000, China.
Zhao B; Shihezi University School of Medicine, Shihezi 832000, China; Key Laboratory for Prevention and Treatment of High Morbidity in Central Asia, National Health and Health Commission, Shihezi 832000, China.
Wang Q; Shihezi University School of Medicine, Shihezi 832000, China; Key Laboratory for Prevention and Treatment of High Morbidity in Central Asia, National Health and Health Commission, Shihezi 832000, China.
Lu J; Shihezi University School of Medicine, Shihezi 832000, China; Key Laboratory for Prevention and Treatment of High Morbidity in Central Asia, National Health and Health Commission, Shihezi 832000, China.
Wu X; Shihezi University School of Medicine, Shihezi 832000, China; The First Affiliated Hospital, Shihezi University School of Medicine, Shihezi 832000, China; Key Laboratory for Prevention and Treatment of High Morbidity in Central Asia, National Health and Health Commission, Shihezi 832000, China. Electronic address: .
Chen X; Shihezi University School of Medicine, Shihezi 832000, China; Key Laboratory for Prevention and Treatment of High Morbidity in Central Asia, National Health and Health Commission, Shihezi 832000, China. Electronic address: .
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Źródło:
International immunopharmacology [Int Immunopharmacol] 2024 Sep 30; Vol. 139, pp. 112807. Date of Electronic Publication: 2024 Jul 27.
Typ publikacji:
Journal Article
MeSH Terms:
Sorafenib*/pharmacology
Sorafenib*/therapeutic use
Carcinoma, Hepatocellular*/drug therapy
Carcinoma, Hepatocellular*/genetics
Liver Neoplasms*/drug therapy
Liver Neoplasms*/genetics
Exosomes*/metabolism
Drug Resistance, Neoplasm*/genetics
MicroRNAs*/genetics
MicroRNAs*/metabolism
Antineoplastic Agents*/pharmacology
Antineoplastic Agents*/therapeutic use
Humans ; Cell Line, Tumor ; Macrophages/drug effects ; Macrophages/immunology ; Proto-Oncogene Proteins c-akt/metabolism ; Tumor-Associated Macrophages/immunology ; Tumor-Associated Macrophages/drug effects ; Tumor-Associated Macrophages/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Gene Expression Regulation, Neoplastic/drug effects ; Apoptosis/drug effects ; THP-1 Cells
Czasopismo naukowe
Full Text Finder  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Novel prognostic alternative splicing events in colorectal Cancer: Impact on immune infiltration and therapy response.
Autorzy:
Xiao Y; Department of Gastroenterology, Fifth Affiliated Hospital of Sun Yat-sen University, No. 52, Meihua East Road, Xiangzhou District, Zhuhai 519000, Guangdong Province, China.
Gao L; Department of Gastroenterology, Fifth Affiliated Hospital of Sun Yat-sen University, No. 52, Meihua East Road, Xiangzhou District, Zhuhai 519000, Guangdong Province, China.
Zhao X; Department of Gastroenterology, Fifth Affiliated Hospital of Sun Yat-sen University, No. 52, Meihua East Road, Xiangzhou District, Zhuhai 519000, Guangdong Province, China.
Zhao W; Department of Gastroenterology, Fifth Affiliated Hospital of Sun Yat-sen University, No. 52, Meihua East Road, Xiangzhou District, Zhuhai 519000, Guangdong Province, China.
Mai L; Department of Gastroenterology, Fifth Affiliated Hospital of Sun Yat-sen University, No. 52, Meihua East Road, Xiangzhou District, Zhuhai 519000, Guangdong Province, China.
Ma C; Department of Gastroenterology, Fifth Affiliated Hospital of Sun Yat-sen University, No. 52, Meihua East Road, Xiangzhou District, Zhuhai 519000, Guangdong Province, China.
Han Y; Department of Gastroenterology, Fifth Affiliated Hospital of Sun Yat-sen University, No. 52, Meihua East Road, Xiangzhou District, Zhuhai 519000, Guangdong Province, China. Electronic address: .
Li X; Department of Gastroenterology, Fifth Affiliated Hospital of Sun Yat-sen University, No. 52, Meihua East Road, Xiangzhou District, Zhuhai 519000, Guangdong Province, China. Electronic address: .
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Źródło:
International immunopharmacology [Int Immunopharmacol] 2024 Sep 30; Vol. 139, pp. 112603. Date of Electronic Publication: 2024 Jul 22.
Typ publikacji:
Journal Article
MeSH Terms:
Colorectal Neoplasms*/genetics
Colorectal Neoplasms*/immunology
Colorectal Neoplasms*/therapy
Alternative Splicing*
Tumor Microenvironment*/genetics
Tumor Microenvironment*/immunology
Humans ; Prognosis ; Gene Expression Regulation, Neoplastic ; Cell Line, Tumor ; Immunotherapy/methods ; Female ; Male ; Cell Movement/genetics ; Cell Proliferation/genetics ; Lymphocytes, Tumor-Infiltrating/immunology ; Biomarkers, Tumor/genetics
Czasopismo naukowe
Full Text Finder  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Inhibitors of APE1 redox and ATM synergistically sensitize osteosarcoma cells to ionizing radiation by inducing ferroptosis.
Autorzy:
Xiao H; Department of Clinical Laboratory Medicine, Southwest Hospital, Army Medical University, Chongqing 400038, China; Department of Clinical Hematology, College of Pharmacy, Army Medical University, Chongqing 400038, China; Cancer Center, Daping Hospital, Army Medical University, Chongqing 400042, China.
Jiang N; Cancer Center, Daping Hospital, Army Medical University, Chongqing 400042, China.
Zhang H; Cancer Center, Daping Hospital, Army Medical University, Chongqing 400042, China.
Wang S; Cancer Center, Daping Hospital, Army Medical University, Chongqing 400042, China.
Pi Q; Cancer Center, Daping Hospital, Army Medical University, Chongqing 400042, China.
Chen H; Cancer Center, Daping Hospital, Army Medical University, Chongqing 400042, China.
He X; Cancer Center, Daping Hospital, Army Medical University, Chongqing 400042, China.
Luo W; Cancer Center, Daping Hospital, Army Medical University, Chongqing 400042, China.
Lu Y; Department of Occupational Health, College of Preventive Medicine, Army Medical University, Chongqing 400038, China. Electronic address: .
Deng Y; Department of Clinical Laboratory Medicine, Southwest Hospital, Army Medical University, Chongqing 400038, China; Department of Clinical Hematology, College of Pharmacy, Army Medical University, Chongqing 400038, China. Electronic address: .
Zhong Z; Cancer Center, Daping Hospital, Army Medical University, Chongqing 400042, China; Department of Oncology, The Fifth People's Hospital of Chongqing, Chongqing 400062, China. Electronic address: .
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Źródło:
International immunopharmacology [Int Immunopharmacol] 2024 Sep 30; Vol. 139, pp. 112672. Date of Electronic Publication: 2024 Jul 19.
Typ publikacji:
Journal Article
MeSH Terms:
Osteosarcoma*/radiotherapy
Osteosarcoma*/metabolism
Osteosarcoma*/drug therapy
DNA-(Apurinic or Apyrimidinic Site) Lyase*/metabolism
Ataxia Telangiectasia Mutated Proteins*/metabolism
Ataxia Telangiectasia Mutated Proteins*/antagonists & inhibitors
Ferroptosis*/drug effects
Oxidation-Reduction*
Bone Neoplasms*/metabolism
Bone Neoplasms*/drug therapy
Bone Neoplasms*/radiotherapy
Radiation, Ionizing*
Humans ; Cell Line, Tumor ; Animals ; Radiation Tolerance/drug effects ; Mice ; Mice, Nude ; Xenograft Model Antitumor Assays ; Propionates ; Benzoquinones
Czasopismo naukowe
Full Text Finder  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Dihydroartemisinin remodels tumor micro-environment and improves cancer immunotherapy through inhibiting cyclin-dependent kinases.
Autorzy:
Zhou Z; State Key Laboratory of Virology, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Department of Clinical Oncology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei Province 430072, China.
Lei J; State Key Laboratory of Virology, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Department of Clinical Oncology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei Province 430072, China; Department of Laboratory Medicine, Xixi Hospital of Hangzhou, Hangzhou, Zhejiang 310023, China. Electronic address: .
Fang J; State Key Laboratory of Virology, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Department of Clinical Oncology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei Province 430072, China.
Chen P; State Key Laboratory of Virology, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Department of Clinical Oncology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei Province 430072, China.
Zhou J; State Key Laboratory of Virology, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Department of Clinical Oncology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei Province 430072, China.
Wang H; State Key Laboratory of Virology, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Department of Clinical Oncology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei Province 430072, China.
Sun Z; State Key Laboratory of Virology, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Department of Clinical Oncology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei Province 430072, China.
Chen Y; State Key Laboratory of Virology, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Department of Clinical Oncology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei Province 430072, China. Electronic address: .
Yin L; State Key Laboratory of Virology, Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Department of Clinical Oncology, Renmin Hospital of Wuhan University, Wuhan University, Wuhan, Hubei Province 430072, China; Hubei Key Laboratory of Biological Targeted Therapy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology. Electronic address: .
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Źródło:
International immunopharmacology [Int Immunopharmacol] 2024 Sep 30; Vol. 139, pp. 112637. Date of Electronic Publication: 2024 Jul 20.
Typ publikacji:
Journal Article
MeSH Terms:
Tumor Microenvironment*/drug effects
Tumor Microenvironment*/immunology
Artemisinins*/pharmacology
Artemisinins*/therapeutic use
Carcinoma, Hepatocellular*/therapy
Carcinoma, Hepatocellular*/immunology
Carcinoma, Hepatocellular*/drug therapy
Liver Neoplasms*/immunology
Liver Neoplasms*/drug therapy
Liver Neoplasms*/therapy
Cyclin-Dependent Kinases*/antagonists & inhibitors
Cyclin-Dependent Kinases*/metabolism
Mice, Inbred C57BL*
Immunotherapy*/methods
CD8-Positive T-Lymphocytes*/immunology
CD8-Positive T-Lymphocytes*/drug effects
Animals ; Mice ; Cell Line, Tumor ; Humans ; Reactive Oxygen Species/metabolism ; Myeloid-Derived Suppressor Cells/drug effects ; Myeloid-Derived Suppressor Cells/immunology ; Male
Czasopismo naukowe
Full Text Finder  Link otwiera się w nowym oknieSzczegóły
Tytuł:
APG-1252 combined with Cabozantinib inhibits hepatocellular carcinoma by suppressing MEK/ERK and CREB/Bcl-xl pathways.
Autorzy:
Di T; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China; Department of Experimental Research, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China.
Luo QY; Department of Clinical Research, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510630, China.
Song JT; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.
Yan XL; Division of Immunology and Allergy, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; Center of Molecular Medicine, Stockholm, Sweden.
Zhang L; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China; Department of Clinical Laboratory, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China.
Pan WT; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.
Guo Y; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.
Lu FT; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.
Sun YT; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China; Department of Medical Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China.
Xia ZF; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China.
Yang LQ; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China; Department of Experimental Research, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China.
Qiu MZ; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China; Department of Experimental Research, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China; Department of Medical Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China. Electronic address: .
Yang DJ; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, China; Department of Experimental Research, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, China. Electronic address: .
Sun J; Department of Clinical Research, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510630, China. Electronic address: .
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Źródło:
International immunopharmacology [Int Immunopharmacol] 2024 Sep 30; Vol. 139, pp. 112615. Date of Electronic Publication: 2024 Jul 20.
Typ publikacji:
Journal Article
MeSH Terms:
Liver Neoplasms*/drug therapy
Liver Neoplasms*/pathology
Carcinoma, Hepatocellular*/drug therapy
Carcinoma, Hepatocellular*/metabolism
Carcinoma, Hepatocellular*/pathology
Anilides*/pharmacology
Anilides*/therapeutic use
Pyridines*/pharmacology
Pyridines*/therapeutic use
bcl-X Protein*/metabolism
Mice, Nude*
Xenograft Model Antitumor Assays*
Cell Proliferation*/drug effects
Animals ; Humans ; Cell Line, Tumor ; Mice ; Apoptosis/drug effects ; Cell Movement/drug effects ; Cyclic AMP Response Element-Binding Protein/metabolism ; Mice, Inbred BALB C ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; MAP Kinase Signaling System/drug effects ; Signal Transduction/drug effects ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Male
Czasopismo naukowe
Full Text Finder  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Anti-tumor effects of telmisartan in glioma-astrocyte non-contact co-cultures: A critical role of astrocytic IL-6-mediated paracrine growth promotion.
Autorzy:
Quan W; Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Xu CS; Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Ma C; Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Chen X; Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Yu DH; Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Li ZY; Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Wang DW; Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Tang F; Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Wan GP; Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Wan J; Department of Cardiology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China.
Wang ZF; Department of Physiology, Wuhan University School of Basic Medical Sciences, Wuhan, Hubei, China. Electronic address: .
Li ZQ; Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China; Hubei International Science and Technology Cooperation Base for Research and Clinical Techniques for Brain Glioma Diagnosis and Treatment, Hubei, China. Electronic address: .
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Źródło:
International immunopharmacology [Int Immunopharmacol] 2024 Sep 30; Vol. 139, pp. 112707. Date of Electronic Publication: 2024 Jul 19.
Typ publikacji:
Journal Article
MeSH Terms:
Telmisartan*/pharmacology
Telmisartan*/therapeutic use
Astrocytes*/drug effects
Astrocytes*/metabolism
Interleukin-6*/metabolism
Coculture Techniques*
Glioma*/drug therapy
Glioma*/metabolism
Glioma*/pathology
Cell Proliferation*/drug effects
STAT3 Transcription Factor*/metabolism
Angiotensin II Type 1 Receptor Blockers*/pharmacology
Angiotensin II Type 1 Receptor Blockers*/therapeutic use
PPAR gamma*/metabolism
Humans ; Cell Line, Tumor ; Paracrine Communication/drug effects ; Cell Movement/drug effects ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Receptors, Interleukin-6/metabolism ; Losartan/pharmacology ; Brain Neoplasms/drug therapy ; Brain Neoplasms/metabolism ; Brain Neoplasms/pathology ; Tumor Microenvironment/drug effects
Czasopismo naukowe
Full Text Finder  Link otwiera się w nowym oknieSzczegóły
Tytuł:
A novel signature constructed by cuproptosis-related RNA methylation regulators suggesting downregulation of YTHDC2 may induce cuproptosis resistance in colorectal cancer.
Autorzy:
Zhao Z; Department of Gastrointestinal Colorectal Surgery, China-Japan Union Hospital of Jilin University, No. 126 Sendai Street, Changchun, Jilin, China. Electronic address: .
Miao Z; Department of Pathogenobiology, College of Basic Medical Sciences, Jilin University, No. 126 Xinmin Street, Changchun, Jilin, China. Electronic address: .
Hou Y; Department of Immunology, College of Basic Medical Sciences, Jilin University, No. 126 Xinmin Street, Changchun, Jilin, China. Electronic address: .
Zhong Y; Department of Pathogenobiology, College of Basic Medical Sciences, Jilin University, No. 126 Xinmin Street, Changchun, Jilin, China. Electronic address: .
Zhang X; Department of Pathogenobiology, College of Basic Medical Sciences, Jilin University, No. 126 Xinmin Street, Changchun, Jilin, China. Electronic address: .
Fang X; Department of Gastrointestinal Colorectal Surgery, China-Japan Union Hospital of Jilin University, No. 126 Sendai Street, Changchun, Jilin, China. Electronic address: .
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Źródło:
International immunopharmacology [Int Immunopharmacol] 2024 Sep 30; Vol. 139, pp. 112691. Date of Electronic Publication: 2024 Jul 18.
Typ publikacji:
Journal Article
MeSH Terms:
Colorectal Neoplasms*/genetics
Colorectal Neoplasms*/immunology
Gene Expression Regulation, Neoplastic*
Humans ; Animals ; Mice ; Down-Regulation ; Cell Proliferation ; Drug Resistance, Neoplasm/genetics ; Cell Line, Tumor ; Tumor Microenvironment/immunology ; Prognosis ; Methylation ; Cell Movement/genetics ; Mice, Nude ; Female ; Male ; RNA Methylation ; RNA Helicases
Czasopismo naukowe
Full Text Finder  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Neogambogic acid enhances anti-PD-1 immunotherapy efficacy by attenuating suppressive function of MDSCs in pancreatic cancer.
Autorzy:
Xun J; Tianjin Nankai Hospital, Tianjin Medical University, Tianjin 300100, China; Tianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Tianjin 300100, China; Institute of Integrative Medicine for Acute Abdominal Diseases, Tianjin 300100, China.
Jiang X; Tianjin Nankai Hospital, Tianjin Medical University, Tianjin 300100, China; Tianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Tianjin 300100, China; Institute of Integrative Medicine for Acute Abdominal Diseases, Tianjin 300100, China.
Liu B; Tianjin Nankai Hospital, Tianjin Medical University, Tianjin 300100, China; Tianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Tianjin 300100, China; Institute of Integrative Medicine for Acute Abdominal Diseases, Tianjin 300100, China.
Hu Z; Tianjin Nankai Hospital, Tianjin Medical University, Tianjin 300100, China; Tianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Tianjin 300100, China; Institute of Integrative Medicine for Acute Abdominal Diseases, Tianjin 300100, China.
Liu J; Tianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Tianjin 300100, China; Institute of Integrative Medicine for Acute Abdominal Diseases, Tianjin 300100, China; Integrated Chinese and Western Medicine Hospital, Tianjin University, Tianjin, China.
Han Y; Tianjin Nankai Hospital, Tianjin Medical University, Tianjin 300100, China; Tianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Tianjin 300100, China; Institute of Integrative Medicine for Acute Abdominal Diseases, Tianjin 300100, China.
Gao R; Tianjin Institute of Medical and Pharmaceutical Sciences, Tianjin 300020, China.
Zhang H; Tianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Tianjin 300100, China; Institute of Integrative Medicine for Acute Abdominal Diseases, Tianjin 300100, China; Integrated Chinese and Western Medicine Hospital, Tianjin University, Tianjin, China.
Yang S; Tianjin Nankai Hospital, Tianjin Medical University, Tianjin 300100, China.
Yu X; Tianjin Nankai Hospital, Tianjin Medical University, Tianjin 300100, China.
Wang X; Tianjin Nankai Hospital, Tianjin Medical University, Tianjin 300100, China.
Yan C; Tianjin Vocational College of Bioengineering, Tianjin 300301, China. Electronic address: .
Zhang Q; Tianjin Nankai Hospital, Tianjin Medical University, Tianjin 300100, China; Tianjin Key Laboratory of Acute Abdomen Disease Associated Organ Injury and ITCWM Repair, Tianjin 300100, China; Institute of Integrative Medicine for Acute Abdominal Diseases, Tianjin 300100, China. Electronic address: .
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Źródło:
International immunopharmacology [Int Immunopharmacol] 2024 Sep 30; Vol. 139, pp. 112696. Date of Electronic Publication: 2024 Jul 16.
Typ publikacji:
Journal Article
MeSH Terms:
Pancreatic Neoplasms*/immunology
Pancreatic Neoplasms*/drug therapy
Pancreatic Neoplasms*/therapy
Pancreatic Neoplasms*/pathology
Myeloid-Derived Suppressor Cells*/immunology
Myeloid-Derived Suppressor Cells*/drug effects
Tumor Microenvironment*/drug effects
Tumor Microenvironment*/immunology
Programmed Cell Death 1 Receptor*/antagonists & inhibitors
Programmed Cell Death 1 Receptor*/immunology
Immune Checkpoint Inhibitors*/pharmacology
Immune Checkpoint Inhibitors*/therapeutic use
Animals ; Mice ; Cell Line, Tumor ; Humans ; Mice, Inbred C57BL ; Immunotherapy/methods ; STAT3 Transcription Factor/metabolism
Czasopismo naukowe
Full Text Finder  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Development of a targeted IL-12 immunotherapy platform for B-cell lymphomas.
Autorzy:
Lee D; Kanaph Therapeutics, Seoul, South Korea; Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea.
Kim D; Kanaph Therapeutics, Seoul, South Korea.
Kim D; Kanaph Therapeutics, Seoul, South Korea.
Kim N; Kanaph Therapeutics, Seoul, South Korea.
Nam YW; Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea.
Lee BC; Kanaph Therapeutics, Seoul, South Korea.
Song J; Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, South Korea. Electronic address: .
Chang J; Kanaph Therapeutics, Seoul, South Korea. Electronic address: .
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Źródło:
International immunopharmacology [Int Immunopharmacol] 2024 Sep 30; Vol. 139, pp. 112600. Date of Electronic Publication: 2024 Jul 13.
Typ publikacji:
Journal Article
MeSH Terms:
Interleukin-12*/genetics
Interleukin-12*/immunology
Lymphoma, B-Cell*/therapy
Lymphoma, B-Cell*/immunology
Immunotherapy*/methods
Animals ; Humans ; Cell Line, Tumor ; Antigens, CD20/immunology ; Mice ; Mice, Inbred BALB C ; Female ; Immunologic Memory
Czasopismo naukowe
Full Text Finder  Link otwiera się w nowym oknieSzczegóły
Tytuł:
EBF1-COX4I2 signaling axis promotes a myofibroblast-like phenotype in cancer-associated fibroblasts (CAFs) and is associated with an immunosuppressive microenvironment.
Autorzy:
Li JP; Jiangsu Province Hospital of Chinese Medicine, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, China; Jiangsu Province Key Laboratory of Tumor Systems Biology and Chinese Medicine, Nanjing, Jiangsu 210029, China.
Liu YJ; Jiangsu Province Hospital of Chinese Medicine, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, China; Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, China.
Wang SS; Jiangsu Province Hospital of Chinese Medicine, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, China; Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, China.
Lu ZH; Jiangsu Province Hospital of Chinese Medicine, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, China; Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, China.
Ye QW; Jiangsu Province Hospital of Chinese Medicine, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, China; Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, China.
Zhou JY; Jiangsu Province Hospital of Chinese Medicine, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, China.
Zou X; Jiangsu Province Hospital of Chinese Medicine, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, China; Jiangsu Province Key Laboratory of Tumor Systems Biology and Chinese Medicine, Nanjing, Jiangsu 210029, China; Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, China; Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine in Prevention and Treatment of Tumor, Nanjing, Jiangsu 210029, China.
Chen YG; Jiangsu Province Hospital of Chinese Medicine, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, China; Jiangsu Province Key Laboratory of Tumor Systems Biology and Chinese Medicine, Nanjing, Jiangsu 210029, China; Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, China; Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine in Prevention and Treatment of Tumor, Nanjing, Jiangsu 210029, China. Electronic address: .
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Źródło:
International immunopharmacology [Int Immunopharmacol] 2024 Sep 30; Vol. 139, pp. 112666. Date of Electronic Publication: 2024 Jul 12.
Typ publikacji:
Journal Article
MeSH Terms:
Tumor Microenvironment*/immunology
Cancer-Associated Fibroblasts*/metabolism
Cancer-Associated Fibroblasts*/immunology
Colorectal Neoplasms*/immunology
Colorectal Neoplasms*/pathology
Colorectal Neoplasms*/genetics
Signal Transduction*
Trans-Activators*/metabolism
Trans-Activators*/genetics
Myofibroblasts*/immunology
Myofibroblasts*/metabolism
Humans ; Animals ; Cell Line, Tumor ; Phenotype ; CD8-Positive T-Lymphocytes/immunology ; Mice ; Gene Expression Regulation, Neoplastic ; Immunotherapy/methods
Czasopismo naukowe
Full Text Finder  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Enhanced desmosome assembly driven by acquired high-level desmoglein-2 promotes phenotypic plasticity and endocrine resistance in ER breast cancer.
Autorzy:
Liu B; Department of Clinical Laboratory, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Molecular Biology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Liu Y; Department of Clinical Laboratory, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Molecular Biology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yang S; Department of Laboratory Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ye J; Department of Clinical Laboratory, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Molecular Biology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Hu J; Department of Clinical Laboratory, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Molecular Biology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chen S; Department of Clinical Laboratory, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Molecular Biology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wu S; Department of Clinical Laboratory, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Molecular Biology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Liu Q; Department of Clinical Laboratory, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Tang F; Department of Breast Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Liu Y; Department of Molecular Biology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
He Y; Department of Molecular Biology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Du Y; Department of Molecular Biology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhang G; Department of Molecular Biology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Guo Q; Department of Molecular Biology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yang C; Department of Clinical Laboratory, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Molecular Biology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China; Faculty of Medical Laboratory Science, College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: .
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Źródło:
Cancer letters [Cancer Lett] 2024 Sep 28; Vol. 600, pp. 217179. Date of Electronic Publication: 2024 Aug 21.
Typ publikacji:
Journal Article
MeSH Terms:
Desmoglein 2*/metabolism
Desmoglein 2*/genetics
Breast Neoplasms*/pathology
Breast Neoplasms*/genetics
Breast Neoplasms*/metabolism
Breast Neoplasms*/drug therapy
Drug Resistance, Neoplasm*
Desmosomes*/metabolism
Wnt Signaling Pathway*
Humans ; Female ; Animals ; Mice ; Fulvestrant/pharmacology ; Antineoplastic Agents, Hormonal/pharmacology ; Receptors, Estrogen/metabolism ; Cell Line, Tumor ; Phenotype ; Plakophilins/metabolism ; Plakophilins/genetics ; Cell Plasticity/drug effects ; Xenograft Model Antitumor Assays ; MCF-7 Cells ; Gene Expression Regulation, Neoplastic ; gamma Catenin
Czasopismo naukowe
Full Text Finder  Link otwiera się w nowym oknieSzczegóły
Tytuł:
Restoration of TFPI2 by LSD1 inhibition suppresses tumor progression and potentiates antitumor immunity in breast cancer.
Autorzy:
Gu T; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Vasilatos SN; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Yin J; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Qin Y; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
Zhang L; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA; Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Medicine, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA.
Davidson NE; Fred Hutchinson Cancer Center and University of Washington, Seattle, WA, USA.
Huang Y; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA; Department of Pharmacology & Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Internal Medicine, Division of Hematology, Oncology, and Blood & Marrow Transplantation, Carver College of Medicine, University of Iowa, Iowa City, IA, USA; Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA. Electronic address: .
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Źródło:
Cancer letters [Cancer Lett] 2024 Sep 28; Vol. 600, pp. 217182. Date of Electronic Publication: 2024 Aug 21.
Typ publikacji:
Journal Article
MeSH Terms:
Histone Demethylases*/metabolism
Histone Demethylases*/genetics
Triple Negative Breast Neoplasms*/pathology
Triple Negative Breast Neoplasms*/immunology
Triple Negative Breast Neoplasms*/genetics
Triple Negative Breast Neoplasms*/metabolism
Disease Progression*
Glycoproteins*/genetics
Glycoproteins*/metabolism
Animals ; Female ; Mice ; Humans ; Mice, Knockout ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; BRCA1 Protein/genetics
Czasopismo naukowe
Full Text Finder  Link otwiera się w nowym oknieSzczegóły
Tytuł:
The E3 ligase TRIM22 functions as a tumor suppressor in breast cancer by targeting CCS for proteasomal degradation to inhibit STAT3 signaling.
Autorzy:
Yang Y; Key Laboratory of Cancer and Microbiome, State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Hao X; Key Laboratory of Cancer and Microbiome, State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China; Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
Zhang J; Key Laboratory of Cancer and Microbiome, State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Gao T; Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
Huo M; Key Laboratory of Cancer and Microbiome, State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Liu W; Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China.
Hu T; Key Laboratory of Cancer and Microbiome, State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Ma T; Key Laboratory of Cancer and Microbiome, State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Yuan B; Key Laboratory of Cancer and Microbiome, State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Zhang M; Key Laboratory of Cancer and Microbiome, State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Teng X; Beijing Key Laboratory of Cancer Invasion and Metastasis Research, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
Yu H; Beijing Key Laboratory of Cancer Invasion and Metastasis Research, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
Huang W; Beijing Key Laboratory of Cancer Invasion and Metastasis Research, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
Wang Y; Key Laboratory of Cancer and Microbiome, State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China; Institute of Cancer Research, Henan Academy of Innovations in Medical Sciences, Zhengzhou, Henan Province, 450000, China; Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070, China; Beijing Key Laboratory of Cancer Invasion and Metastasis Research, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China. Electronic address: .
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Źródło:
Cancer letters [Cancer Lett] 2024 Sep 28; Vol. 600, pp. 217157. Date of Electronic Publication: 2024 Aug 08.
Typ publikacji:
Journal Article
MeSH Terms:
Breast Neoplasms*/pathology
Breast Neoplasms*/genetics
Breast Neoplasms*/metabolism
Tripartite Motif Proteins*/genetics
Tripartite Motif Proteins*/metabolism
STAT3 Transcription Factor*/metabolism
STAT3 Transcription Factor*/genetics
Minor Histocompatibility Antigens*/genetics
Minor Histocompatibility Antigens*/metabolism
Cell Proliferation*
Signal Transduction*
Ubiquitination*
Humans ; Female ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Cell Line, Tumor ; Proteasome Endopeptidase Complex/metabolism ; Gene Expression Regulation, Neoplastic ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitin-Protein Ligases/genetics ; Prognosis ; Neoplasm Invasiveness ; Proteolysis ; MCF-7 Cells
Czasopismo naukowe
Full Text Finder  Link otwiera się w nowym oknieSzczegóły
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