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Wyszukujesz frazę ""Cells, Cultured"" wg kryterium: Temat


Tytuł :
Do Patient-derived Spheroid Culture Models Have Relevance in Chondrosarcoma Research?
Autorzy :
Ma R; R. Ma, J. Mandell, F. Lu, T. Heim, R. Watters, K. R. Weiss, Musculoskeletal Oncology Laboratory, University of Pittsburgh School of Medicine Department of Orthopaedic Surgery, Pittsburgh, PA, USA.; R. Ma, F. Lu, School of Medicine, Tsinghua University, Beijing, China.
Mandell J; R. Ma, J. Mandell, F. Lu, T. Heim, R. Watters, K. R. Weiss, Musculoskeletal Oncology Laboratory, University of Pittsburgh School of Medicine Department of Orthopaedic Surgery, Pittsburgh, PA, USA.; J. Mandell, Department of Infectious Diseases and Microbiology, University of Pittsburgh, PA, USA.
Lu F; R. Ma, J. Mandell, F. Lu, T. Heim, R. Watters, K. R. Weiss, Musculoskeletal Oncology Laboratory, University of Pittsburgh School of Medicine Department of Orthopaedic Surgery, Pittsburgh, PA, USA.; R. Ma, F. Lu, School of Medicine, Tsinghua University, Beijing, China.
Heim T; R. Ma, J. Mandell, F. Lu, T. Heim, R. Watters, K. R. Weiss, Musculoskeletal Oncology Laboratory, University of Pittsburgh School of Medicine Department of Orthopaedic Surgery, Pittsburgh, PA, USA.
Schoedel K; K. Schoedel, A. Duensing, K. R. Weiss, Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.
Duensing A; A. Duensing, R. Watters, K. R. Weiss, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Watters RJ; R. Ma, J. Mandell, F. Lu, T. Heim, R. Watters, K. R. Weiss, Musculoskeletal Oncology Laboratory, University of Pittsburgh School of Medicine Department of Orthopaedic Surgery, Pittsburgh, PA, USA.; A. Duensing, R. Watters, K. R. Weiss, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
Weiss KR; R. Ma, J. Mandell, F. Lu, T. Heim, R. Watters, K. R. Weiss, Musculoskeletal Oncology Laboratory, University of Pittsburgh School of Medicine Department of Orthopaedic Surgery, Pittsburgh, PA, USA.; A. Duensing, R. Watters, K. R. Weiss, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
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Źródło :
Clinical orthopaedics and related research [Clin Orthop Relat Res] 2021 Mar 01; Vol. 479 (3), pp. 477-490.
Typ publikacji :
Journal Article
MeSH Terms :
Bone Neoplasms*
Chondrosarcoma*
Models, Biological*
Spheroids, Cellular*
Tumor Cells, Cultured*
Feasibility Studies ; Humans
Czasopismo naukowe
Tytuł :
Mind your media.
Autorzy :
Lagziel S; Faculty of Computer Science, Technion, Haifa, Israel.
Gottlieb E; Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel. .
Shlomi T; Faculty of Computer Science, Technion, Haifa, Israel. .; Faculty of Biology, Technion, Haifa, Israel. .; Lokey Center for Life Science and Engineering, Technion, Haifa, Israel. .
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Źródło :
Nature metabolism [Nat Metab] 2020 Dec; Vol. 2 (12), pp. 1369-1372.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Cells, Cultured*
Culture Media*
Animals ; Cell Line, Tumor ; Humans ; Neoplasms/metabolism
Czasopismo naukowe
Tytuł :
Inhibition of an organophosphate-detoxifying bacterial phosphotriesterase by albumin and plasma thiol components.
Autorzy :
Köhler A; Chair of Biological Chemistry, Technische Universität München, Emil-Erlenmeyer-Forum 5, 85354 Freising, Germany; Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstr. 11, 80937 Munich, Germany. Electronic address: .
Job L; Chair of Biological Chemistry, Technische Universität München, Emil-Erlenmeyer-Forum 5, 85354 Freising, Germany. Electronic address: .
Worek F; Bundeswehr Institute of Pharmacology and Toxicology, Neuherbergstr. 11, 80937 Munich, Germany. Electronic address: .
Skerra A; Chair of Biological Chemistry, Technische Universität München, Emil-Erlenmeyer-Forum 5, 85354 Freising, Germany. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Oct 10; Vol. 350, pp. 194-201. Date of Electronic Publication: 2021 Jul 22.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Albumins/*pharmacology
Bacterial Proteins/*pharmacology
Enzyme Inhibitors/*pharmacology
Organophosphate Poisoning/*drug therapy
Phosphoric Triester Hydrolases/*metabolism
Phosphoric Triester Hydrolases/*therapeutic use
Sulfhydryl Compounds/*metabolism
Albumins/metabolism ; Bacterial Proteins/metabolism ; Caulobacteraceae/chemistry ; Cells, Cultured/drug effects ; Cells, Cultured/metabolism ; Enzyme Inhibitors/metabolism ; Models, Animal ; Organophosphorus Compounds/metabolism ; Sulfhydryl Compounds/blood
SCR Organism :
Brevundimonas diminuta
Czasopismo naukowe
Tytuł :
Human prostate epithelial cells and prostate-derived stem cells malignantly transformed in vitro with sodium arsenite show impaired Toll like receptor -3 (TLR3)-associated anti-tumor pathway.
Autorzy :
Alvarado-Morales I; Laboratorio de Inmunotoxicología. Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, Manuel Nava 6, Zona Universitaria, 78290, SLP, Mexico.
Olivares-Illana V; Laboratorio de Interacciones Biomoleculares y Cáncer, Instituto de Física, Universidad Autónoma de San Luis Potosí, Manuel Nava 6, Zona Universitaria, 78290, SLP, Mexico.
Arenas-Huertero C; Laboratorio de Biología, Facultad de Ciencias, Universidad Autónoma de San Luis Potosí. Av, Chapultepec, 1570. 78295, SLP, Mexico.
Reynaga-Hernández E; Laboratorio de Inmunotoxicología. Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, Manuel Nava 6, Zona Universitaria, 78290, SLP, Mexico.
Layseca-Espinosa E; Centro de Investigación en Biomedicina y Salud, Facultad de Medicina, Universidad autónoma de San Luis Potosí, Sierra Leona 550 Lomas de San Luis, 78210, SLP, Mexico.
Tokar EJ; National Toxicology Program Laboratory, NTP. National Institutitute of Environmental Health Sciences, NIEHS, Durham, NC, 27709, United States.
Escudero-Lourdes C; Laboratorio de Inmunotoxicología. Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, Manuel Nava 6, Zona Universitaria, 78290, SLP, Mexico. Electronic address: .
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Źródło :
Toxicology letters [Toxicol Lett] 2021 Oct 10; Vol. 350, pp. 185-193. Date of Electronic Publication: 2021 Jul 23.
Typ publikacji :
Comparative Study; Journal Article
MeSH Terms :
Epithelial Cells/*drug effects
Epithelial Cells/*metabolism
Neoplastic Stem Cells/*drug effects
Neoplastic Stem Cells/*metabolism
Prostatic Neoplasms/*genetics
Prostatic Neoplasms/*metabolism
Sodium Compounds/*toxicity
Toll-Like Receptors/*drug effects
Adult ; Aged ; Aged, 80 and over ; Apoptosis/drug effects ; Cell Transformation, Neoplastic/drug effects ; Cell Transformation, Neoplastic/metabolism ; Cells, Cultured/drug effects ; Cells, Cultured/metabolism ; Genetic Variation ; Genotype ; Humans ; Male ; Middle Aged ; Prostate/drug effects ; Prostate/metabolism ; Prostatic Neoplasms/physiopathology ; Sodium Compounds/metabolism ; Toll-Like Receptors/metabolism
Czasopismo naukowe
Tytuł :
Hydroxyethyl chitosan hydrogels for enhancing breast cancer cell tumorigenesis.
Autorzy :
Hou G; State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an 710049, China.
Sun T; State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an 710049, China.
Qian J; State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an 710049, China. Electronic address: .
Zhang Y; State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an 710049, China.
Guo M; State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an 710049, China.
Xu W; State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an 710049, China.
Wang J; State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, Xi'an 710049, China.
Suo A; Department of Oncology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China. Electronic address: .
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Źródło :
International journal of biological macromolecules [Int J Biol Macromol] 2021 Aug 01; Vol. 184, pp. 768-775. Date of Electronic Publication: 2021 Jun 24.
Typ publikacji :
Journal Article
MeSH Terms :
Breast Neoplasms/*metabolism
Chitosan/*chemistry
Extracellular Matrix/*metabolism
Hyaluronic Acid/*chemistry
Hydrogels/*chemical synthesis
Spheroids, Cellular/*cytology
Breast Neoplasms/pathology ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Hydrogels/chemistry ; Hydrogels/pharmacology ; MCF-7 Cells ; Matrix Metalloproteinase 2/metabolism ; Porosity ; Schiff Bases ; Spheroids, Cellular/drug effects ; Spheroids, Cellular/metabolism ; Transforming Growth Factor beta/metabolism ; Tumor Cells, Cultured/cytology ; Tumor Cells, Cultured/drug effects ; Tumor Cells, Cultured/metabolism ; Up-Regulation ; Vascular Endothelial Growth Factor A/metabolism
Czasopismo naukowe
Tytuł :
Mathematical modelling reveals cellular dynamics within tumour spheroids.
Autorzy :
Bull JA; Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, United Kingdom.
Mech F; Roche Pharma Research and Early Development, pRED Informatics, Roche Innovation Centre Munich, Germany.
Quaiser T; Roche Pharma Research and Early Development, pRED Informatics, Roche Innovation Centre Munich, Germany.
Waters SL; Oxford Centre for Industrial and Applied Mathematics, Mathematical Institute, University of Oxford, Oxford, United Kingdom.
Byrne HM; Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, United Kingdom.
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Źródło :
PLoS computational biology [PLoS Comput Biol] 2020 Aug 18; Vol. 16 (8), pp. e1007961. Date of Electronic Publication: 2020 Aug 18 (Print Publication: 2020).
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Models, Biological*
Spheroids, Cellular*/cytology
Spheroids, Cellular*/physiology
Tumor Cells, Cultured*/cytology
Tumor Cells, Cultured*/physiology
Animals ; Biomechanical Phenomena ; Cell Death/physiology ; Cell Hypoxia/physiology ; Cell Proliferation/physiology ; Computational Biology ; Humans
Czasopismo naukowe
Tytuł :
BYSTANDER WI-38 CELLS MODULATE DNA DOUBLE-STRAND BREAK REPAIR IN MICROBEAM-TARGETED A549 CELLS THROUGH GAP JUNCTION INTERCELLULAR COMMUNICATION.
Autorzy :
Kobayashi A; SPICE-BIO research core, International Open Laboratory, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Anagawa 4-9-1, Inage-ku, Chiba, Japan.; Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.
Autsavapromporn N; SPICE-BIO research core, International Open Laboratory, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Anagawa 4-9-1, Inage-ku, Chiba, Japan.; Division of Therapeutic Radiology and Oncology, Department of Radiology, Faculty of Medicine, Chiang Mai University, Thailand.
Ahmad TAFT; SPICE-BIO research core, International Open Laboratory, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Anagawa 4-9-1, Inage-ku, Chiba, Japan.; Division of Agrotechnology and Biosciences, Malaysian Nuclear Agency, Bangi, Kajang, Malaysia.
Oikawa M; SPICE-BIO research core, International Open Laboratory, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Anagawa 4-9-1, Inage-ku, Chiba, Japan.
Homma-Takeda S; SPICE-BIO research core, International Open Laboratory, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Anagawa 4-9-1, Inage-ku, Chiba, Japan.
Furusawa Y; SPICE-BIO research core, International Open Laboratory, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Anagawa 4-9-1, Inage-ku, Chiba, Japan.
Wang J; Key Laboratory of Ion Beam Bioengineering, Hefei Institute of Physical Science, Chinese Academy of Sciences and Anhui Province, No. 350 of Shushanhu Road, Hefei, PR China.
Konishi T; SPICE-BIO research core, International Open Laboratory, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Anagawa 4-9-1, Inage-ku, Chiba, Japan.
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Źródło :
Radiation protection dosimetry [Radiat Prot Dosimetry] 2019 May 01; Vol. 183 (1-2), pp. 142-146.
Typ publikacji :
Journal Article
MeSH Terms :
A549 Cells/*radiation effects
Cell Communication/*radiation effects
DNA Breaks, Double-Stranded/*radiation effects
Gap Junctions/*radiation effects
Lung Neoplasms/*radiotherapy
Tumor Cells, Cultured/*radiation effects
Bystander Effect/radiation effects ; Cells, Cultured/radiation effects ; Coculture Techniques ; DNA Repair ; Fibroblasts/radiation effects ; Histones/analysis ; Humans ; Protons
Czasopismo naukowe
Tytuł :
Stanniocalcin 1 is overexpressed in multipotent mesenchymal stromal cells from acute myeloid leukemia patients.
Autorzy :
Schelker RC; Department of Internal Medicine III, Hematology & Oncology, University Hospital of Regensburg, Regensburg, Germany.
Kratzer A; Department of Internal Medicine III, Hematology & Oncology, University Hospital of Regensburg, Regensburg, Germany.
Müller G; Department of Internal Medicine III, Hematology & Oncology, University Hospital of Regensburg, Regensburg, Germany.
Brochhausen C; Institute of Pathology, University of Regensburg, Regensburg, Germany.
Hart C; Department of Internal Medicine III, Hematology & Oncology, University Hospital of Regensburg, Regensburg, Germany.
Stempfl T; Center of Excellence for Fluorescent Bioanalytics (KFB), University of Regensburg, Regensburg, Germany.
Heudobler D; Department of Internal Medicine III, Hematology & Oncology, University Hospital of Regensburg, Regensburg, Germany.
Moehle C; Center of Excellence for Fluorescent Bioanalytics (KFB), University of Regensburg, Regensburg, Germany.
Herr W; Department of Internal Medicine III, Hematology & Oncology, University Hospital of Regensburg, Regensburg, Germany.
Iberl S; Department of Internal Medicine III, Hematology & Oncology, University Hospital of Regensburg, Regensburg, Germany.
Grassinger J; Department of Internal Medicine III, Hematology & Oncology, University Hospital of Regensburg, Regensburg, Germany.; St. Elisabeth Hospital, Straubing, Germany.
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Źródło :
Hematology (Amsterdam, Netherlands) [Hematology] 2021 Dec; Vol. 26 (1), pp. 565-576.
Typ publikacji :
Journal Article
MeSH Terms :
Up-Regulation*
Glycoproteins/*genetics
Leukemia, Myeloid, Acute/*genetics
Mesenchymal Stem Cells/*pathology
Adult ; Aged ; Cells, Cultured ; Female ; Glycoproteins/analysis ; Humans ; Leukemia, Myeloid, Acute/pathology ; Male ; Mesenchymal Stem Cells/metabolism ; Middle Aged ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Oxidized fish oils increased lipid deposition via oxidative stress-mediated mitochondrial dysfunction and the CREB1-Bcl2-Beclin1 pathway in the liver tissues and hepatocytes of yellow catfish.
Autorzy :
Zhang DG; Laboratory of Molecular Nutrition, Huazhong Agricultural University, Wuhan 430070, China.
Zhao T; Laboratory of Molecular Nutrition, Huazhong Agricultural University, Wuhan 430070, China.
Hogstrand C; Diabetes and Nutritional Sciences Division, School of Medicine, King's College London, London, UK.
Ye HM; Laboratory of Molecular Nutrition, Huazhong Agricultural University, Wuhan 430070, China.
Xu XJ; Laboratory of Molecular Nutrition, Huazhong Agricultural University, Wuhan 430070, China.
Luo Z; Laboratory of Molecular Nutrition, Huazhong Agricultural University, Wuhan 430070, China. Electronic address: .
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Źródło :
Food chemistry [Food Chem] 2021 Oct 30; Vol. 360, pp. 129814. Date of Electronic Publication: 2021 May 12.
Typ publikacji :
Journal Article
MeSH Terms :
Catfishes/*metabolism
Fish Oils/*pharmacology
Hepatocytes/*drug effects
Liver/*drug effects
Mitochondria/*drug effects
Oxidative Stress/*drug effects
Signal Transduction/*drug effects
Animals ; Autophagy ; Beclin-1/metabolism ; Cells, Cultured ; Cyclic AMP Response Element-Binding Protein/metabolism ; Hepatocytes/metabolism ; Lipid Metabolism/drug effects ; Lipids ; Liver/metabolism ; Mitochondria/metabolism ; Oxidation-Reduction ; Proto-Oncogene Proteins c-bcl-2/metabolism
Czasopismo naukowe
Tytuł :
HA of H1N1 enhanced the expression of ICAM-1 and IL-6 in HUVECs and pathological injury in the lungs in mice.
Autorzy :
Zhao MZ; Affiliated Hospital of Chengde Medical University, Chengde 067000, Hebei, China.
Guo X; Affiliated Hospital of Chengde Medical University, Chengde 067000, Hebei, China.
Sun B; Affiliated Hospital of Chengde Medical University, Chengde 067000, Hebei, China.
Sun XF; Affiliated Hospital of Chengde Medical University, Chengde 067000, Hebei, China.
Pang GF; Affiliated Hospital of Chengde Medical University, Chengde 067000, Hebei, China.
Yang LY; Affiliated Hospital of Chengde Medical University, Chengde 067000, Hebei, China.
Zhao X; Affiliated Hospital of Chengde Medical University, Chengde 067000, Hebei, China.
Sun LX; Affiliated Hospital of Chengde Medical University, Chengde 067000, Hebei, China.
Zhang Q; Affiliated Hospital of Chengde Medical University, Chengde 067000, Hebei, China. Electronic address: .
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Źródło :
Gene [Gene] 2021 Oct 30; Vol. 801, pp. 145854. Date of Electronic Publication: 2021 Jul 16.
Typ publikacji :
Journal Article
MeSH Terms :
Hemagglutinin Glycoproteins, Influenza Virus/*physiology
Influenza A Virus, H1N1 Subtype/*physiology
Intercellular Adhesion Molecule-1/*metabolism
Interleukin-6/*metabolism
Lung/*pathology
Cells, Cultured ; Human Umbilical Vein Endothelial Cells ; Humans ; Lung/metabolism ; Real-Time Polymerase Chain Reaction
Czasopismo naukowe
Tytuł :
Genome-wide expression analysis reveal host genes involved in immediate-early infections of different sheeppox virus strains.
Autorzy :
Sonowal J; ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, UP, India.
Lal Patel C; ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, UP, India.
Kumar Gandham R; National Institute of Animal Biotechnology, Hyderabad, India.
Sajjanar B; ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, UP, India.
Ishaq Nabi Khan R; ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, UP, India.
Ranjan Praharaj M; National Institute of Animal Biotechnology, Hyderabad, India.
Akram Malla W; ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, UP, India.
Kumar D; ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, UP, India.
Dev K; ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, UP, India.
Barkathullah N; ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, UP, India.
Bharali K; ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, UP, India.
Dubey A; ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, UP, India.
Lalita D; ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, UP, India.
Zafir I; ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, UP, India.
Mishra BP; ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, UP, India.
Mishra B; ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, UP, India. Electronic address: .
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Źródło :
Gene [Gene] 2021 Oct 30; Vol. 801, pp. 145850. Date of Electronic Publication: 2021 Jul 15.
Typ publikacji :
Journal Article
MeSH Terms :
Capripoxvirus*/pathogenicity
Genes, Immediate-Early*
Host-Pathogen Interactions/*genetics
Poxviridae Infections/*genetics
Sheep Diseases/*genetics
Animals ; Cells, Cultured ; Gene Expression ; Male ; Poxviridae Infections/veterinary ; Protein Interaction Maps/genetics ; Sheep ; Sheep Diseases/virology
Czasopismo naukowe
Tytuł :
FGGY carbohydrate kinase domain containing is expressed and alternatively spliced in skeletal muscle and attenuates MAP kinase and Akt signaling.
Autorzy :
Smith AL; University of North Florida, Department of Biology, 1 UNF Drive, Jacksonville, FL 32224, USA.
Gjoka E; University of North Florida, Department of Biology, 1 UNF Drive, Jacksonville, FL 32224, USA.
Izhar M; University of North Florida, Department of Biology, 1 UNF Drive, Jacksonville, FL 32224, USA.
Novo KJ; University of North Florida, Department of Biology, 1 UNF Drive, Jacksonville, FL 32224, USA.
Mason BC; University of North Florida, Department of Biology, 1 UNF Drive, Jacksonville, FL 32224, USA.
De Las Casas A; University of North Florida, Department of Biology, 1 UNF Drive, Jacksonville, FL 32224, USA.
Waddell DS; University of North Florida, Department of Biology, 1 UNF Drive, Jacksonville, FL 32224, USA. Electronic address: .
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Źródło :
Gene [Gene] 2021 Oct 20; Vol. 800, pp. 145836. Date of Electronic Publication: 2021 Jul 16.
Typ publikacji :
Journal Article
MeSH Terms :
RNA Splice Sites*
Muscle, Skeletal/*enzymology
Muscular Atrophy/*genetics
Phosphotransferases/*genetics
Phosphotransferases/*metabolism
Animals ; Cell Differentiation/genetics ; Cells, Cultured ; Cytoplasm/enzymology ; Gene Expression Regulation, Enzymologic ; MAP Kinase Signaling System/genetics ; Mice ; Myoblasts/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction
Czasopismo naukowe
Tytuł :
Synthesis and approbation of new neuroprotective chemicals of pyrrolyl- and indolylazine classes in a cell model of Alzheimer's disease.
Autorzy :
Dutysheva EA; Institute of Cytology, Russian Academy of Sciences, St. Petersburg, 194064, Russia.
Utepova IA; Ural Federal University, Ekaterinburg, 620002, Russia; Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg, 620108, Russia.
Trestsova MA; Ural Federal University, Ekaterinburg, 620002, Russia; Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg, 620108, Russia.
Anisimov AS; Institute of Cytology, Russian Academy of Sciences, St. Petersburg, 194064, Russia.
Charushin VN; Ural Federal University, Ekaterinburg, 620002, Russia; Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg, 620108, Russia.
Chupakhin ON; Ural Federal University, Ekaterinburg, 620002, Russia; Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg, 620108, Russia.
Margulis BA; Institute of Cytology, Russian Academy of Sciences, St. Petersburg, 194064, Russia.
Guzhova IV; Institute of Cytology, Russian Academy of Sciences, St. Petersburg, 194064, Russia.
Lazarev VF; Institute of Cytology, Russian Academy of Sciences, St. Petersburg, 194064, Russia. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Oct 15; Vol. 222, pp. 113577. Date of Electronic Publication: 2021 May 26.
Typ publikacji :
Journal Article
MeSH Terms :
Alzheimer Disease/*drug therapy
Hydrazines/*pharmacology
Neurons/*drug effects
Neuroprotective Agents/*pharmacology
Pyrroles/*pharmacology
Alzheimer Disease/metabolism ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/antagonists & inhibitors ; Amyloid beta-Peptides/metabolism ; Apoptosis/drug effects ; Cells, Cultured ; Dose-Response Relationship, Drug ; Humans ; Hydrazines/chemical synthesis ; Hydrazines/chemistry ; Molecular Structure ; Neurons/metabolism ; Neurons/pathology ; Neuroprotective Agents/chemical synthesis ; Neuroprotective Agents/chemistry ; Pyrroles/chemical synthesis ; Pyrroles/chemistry ; Structure-Activity Relationship
Czasopismo naukowe
Tytuł :
Oncogenic potential of human pluripotent stem cell-derived lung organoids with HER2 overexpression.
Autorzy :
Miura A; Department of Regenerative Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.; Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Yamada D; Department of Regenerative Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Nakamura M; Precision Health, Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.
Tomida S; Center for Comprehensive Genomic Medicine, Okayama University Hospital, Okayama, Japan.
Shimizu D; Department of Regenerative Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.; Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Jiang Y; Department of Regenerative Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Takao T; Department of Regenerative Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Yamamoto H; Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Suzawa K; Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Shien K; Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Yamane M; Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Sakaguchi M; Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Toyooka S; Department of General Thoracic Surgery and Breast and Endocrinological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Takarada T; Department of Regenerative Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
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Źródło :
International journal of cancer [Int J Cancer] 2021 Oct 15; Vol. 149 (8), pp. 1593-1604. Date of Electronic Publication: 2021 Jul 07.
Typ publikacji :
Journal Article; Research Support, Non-U.S. Gov't
MeSH Terms :
Carcinogenesis*
Gene Expression Regulation, Neoplastic*
Adenocarcinoma of Lung/*pathology
Induced Pluripotent Stem Cells/*pathology
Lung Neoplasms/*pathology
Organoids/*pathology
Receptor, ErbB-2/*metabolism
Adenocarcinoma of Lung/genetics ; Adenocarcinoma of Lung/metabolism ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Cell Differentiation ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Organoids/metabolism ; Receptor, ErbB-2/genetics ; Transcriptome ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Metabolic and conformational stabilization of a VEGF-mimetic beta-hairpin peptide by click-chemistry.
Autorzy :
De Rosa L; Istituto di Biostrutture e Bioimmagini, CNR, Via Mezzocannone 16, 80134, Napoli, Italy.
Capasso D; CESTEV, Università di Napoli 'Federico II', Via De Amicis 95, 80134, Napoli, Italy; CIRPeB Università di Napoli 'Federico II' Via Mezzocannone 16, 80134, Napoli, Italy.
Diana D; Istituto di Biostrutture e Bioimmagini, CNR, Via Mezzocannone 16, 80134, Napoli, Italy.
Stefania R; Dipartimento di Biotecnologie Molecolari e Scienze per La Salute, Università di Torino, Via Nizza 52, 10126, Torino, Italy.
Di Stasi R; Istituto di Biostrutture e Bioimmagini, CNR, Via Mezzocannone 16, 80134, Napoli, Italy.
Fattorusso R; CIRPeB Università di Napoli 'Federico II' Via Mezzocannone 16, 80134, Napoli, Italy; Dipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Università Della Campania 'Luigi Vanvitelli', Via Vivaldi 43, 81100, Caserta, Italy.
D'Andrea LD; Istituto di Scienze e Tecnologie Chimiche 'Giulio Natta', CNR, Via M. Bianco 9, 20131, Milano, Italy. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Oct 15; Vol. 222, pp. 113575. Date of Electronic Publication: 2021 May 26.
Typ publikacji :
Journal Article
MeSH Terms :
Peptides/*chemistry
Vascular Endothelial Growth Factor A/*chemistry
Cell Proliferation/drug effects ; Cells, Cultured ; Click Chemistry ; Humans ; Molecular Conformation ; Peptides/pharmacology
Czasopismo naukowe
Tytuł :
Design, synthesis, and biological evaluation of novel sulindac derivatives as partial agonists of PPARγ with potential anti-diabetic efficacy.
Autorzy :
Huang F; School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Xiamen, Fujian, 361102, China.
Zeng Z; School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Xiamen, Fujian, 361102, China; High Throughput Drug Screening Platform, Xiamen University, Xiamen, Fujian, 361102, China.
Zhang W; School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Xiamen, Fujian, 361102, China.
Yan Z; School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Xiamen, Fujian, 361102, China.
Chen J; School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Xiamen, Fujian, 361102, China.
Yu L; School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Xiamen, Fujian, 361102, China.
Yang Q; School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Xiamen, Fujian, 361102, China.
Li Y; School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Xiamen, Fujian, 361102, China.
Yu H; School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Xiamen, Fujian, 361102, China.
Chen J; School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Xiamen, Fujian, 361102, China.
Wu C; School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Xiamen, Fujian, 361102, China.
Zhang XK; School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Xiamen, Fujian, 361102, China; High Throughput Drug Screening Platform, Xiamen University, Xiamen, Fujian, 361102, China.
Su Y; NucMito Pharmaceuticals, Xiamen, Fujian, 361101, China. Electronic address: .
Zhou H; School of Pharmaceutical Sciences, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Xiamen, Fujian, 361102, China; High Throughput Drug Screening Platform, Xiamen University, Xiamen, Fujian, 361102, China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Oct 15; Vol. 222, pp. 113542. Date of Electronic Publication: 2021 May 24.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Design*
Diabetes Mellitus, Experimental/*drug therapy
Hypoglycemic Agents/*pharmacology
PPAR gamma/*agonists
Sulindac/*pharmacology
Animals ; Cells, Cultured ; Diabetes Mellitus, Experimental/metabolism ; Dose-Response Relationship, Drug ; Humans ; Hypoglycemic Agents/chemical synthesis ; Hypoglycemic Agents/chemistry ; Mice ; Mice, Inbred C57BL ; Molecular Structure ; Rats ; Rats, Sprague-Dawley ; Structure-Activity Relationship ; Sulindac/chemical synthesis ; Sulindac/chemistry
Czasopismo naukowe
Tytuł :
Doxorubicin-loaded natural daptomycin micelles with enhanced targeting and anti-tumor effect in vivo.
Autorzy :
Guo Q; Key Laboratory of Applied Chemistry, Hebei Key Laboratory of Heavy Metal Deep-remediation in Water and Resource Reuse, College of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, 066004, China; State Key Laboratory of Materials Science and Technology, Yanshan University, Qinhuangdao, 066004, China.
Zhang L; Key Laboratory of Applied Chemistry, Hebei Key Laboratory of Heavy Metal Deep-remediation in Water and Resource Reuse, College of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, 066004, China.
He M; Key Laboratory of Applied Chemistry, Hebei Key Laboratory of Heavy Metal Deep-remediation in Water and Resource Reuse, College of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, 066004, China.
Jiang X; Hebei Key Laboratory for Chronic Diseases, School of Basic Medicine, North China University of Science and Technology, Tangshan, 063210, China.
Tian J; Hebei Key Laboratory for Chronic Diseases, School of Basic Medicine, North China University of Science and Technology, Tangshan, 063210, China.
Li Q; Key Laboratory of Applied Chemistry, Hebei Key Laboratory of Heavy Metal Deep-remediation in Water and Resource Reuse, College of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, 066004, China.
Liu Z; Key Laboratory of Applied Chemistry, Hebei Key Laboratory of Heavy Metal Deep-remediation in Water and Resource Reuse, College of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, 066004, China.
Wang L; Key Laboratory of Applied Chemistry, Hebei Key Laboratory of Heavy Metal Deep-remediation in Water and Resource Reuse, College of Environmental and Chemical Engineering, Yanshan University, Qinhuangdao, 066004, China; State Key Laboratory of Materials Science and Technology, Yanshan University, Qinhuangdao, 066004, China. Electronic address: .
Sun H; Ocean NanoTech, LLC, San Diego, CA, 92126, USA. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Oct 15; Vol. 222, pp. 113582. Date of Electronic Publication: 2021 Jun 02.
Typ publikacji :
Journal Article
MeSH Terms :
Anti-Bacterial Agents/*pharmacology
Antibiotics, Antineoplastic/*pharmacology
Biological Products/*pharmacology
Daptomycin/*pharmacology
Doxorubicin/*pharmacology
Animals ; Anti-Bacterial Agents/chemistry ; Antibiotics, Antineoplastic/chemistry ; Biological Products/chemistry ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Daptomycin/chemistry ; Dose-Response Relationship, Drug ; Doxorubicin/chemistry ; Drug Screening Assays, Antitumor ; Escherichia coli/drug effects ; Humans ; Mice ; Micelles ; Molecular Structure ; Staphylococcus aureus/drug effects ; Structure-Activity Relationship ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Development of photocontrolled BRD4 PROTACs for tongue squamous cell carcinoma (TSCC).
Autorzy :
Li Z; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.
Ma S; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.
Yang X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.
Zhang L; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.
Liang D; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.
Dong G; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.
Du L; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China. Electronic address: .
Lv Z; Department of Head and Neck Surgery, Shandong Provincial ENT Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250022, China. Electronic address: .
Li M; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Oct 15; Vol. 222, pp. 113608. Date of Electronic Publication: 2021 Jun 05.
Typ publikacji :
Journal Article
MeSH Terms :
Drug Development*
Antineoplastic Agents/*pharmacology
Carcinoma, Squamous Cell/*drug therapy
Cell Cycle Proteins/*antagonists & inhibitors
Small Molecule Libraries/*pharmacology
Tongue Neoplasms/*drug therapy
Transcription Factors/*antagonists & inhibitors
Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Carcinoma, Squamous Cell/metabolism ; Carcinoma, Squamous Cell/pathology ; Cell Cycle Proteins/metabolism ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cells, Cultured ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Mice ; Mice, Nude ; Molecular Structure ; Neoplasms, Experimental/drug therapy ; Neoplasms, Experimental/metabolism ; Neoplasms, Experimental/pathology ; Photochemical Processes ; Proteolysis ; Small Molecule Libraries/chemical synthesis ; Small Molecule Libraries/chemistry ; Structure-Activity Relationship ; Tongue Neoplasms/metabolism ; Tongue Neoplasms/pathology ; Transcription Factors/metabolism ; Zebrafish
Czasopismo naukowe
Tytuł :
5-Aminonaphthalene derivatives as selective nonnucleoside nuclear receptor binding SET domain-protein 2 (NSD2) inhibitors for the treatment of multiple myeloma.
Autorzy :
Wang S; State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China.
Yang H; State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China.
Su M; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Qixia District, Nanjing, 210023, China.
Lian F; State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China.
Cong Z; State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China.
Wei R; State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China.
Zhou Y; State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China; Zhongshan Institute of Drug Discovery, Institution for Drug Discovery Innovation, Chinese Academy of Science, Zhongshan, 528400, China.
Li X; State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China.
Zheng X; State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China.
Li C; State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, UCAS, Hangzhou, 310024, China.
Fu X; State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China.
Han X; State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China.
Shi Q; State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China.
Li C; State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China.
Zhang N; State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China.
Geng M; State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China.
Liu H; State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Qixia District, Nanjing, 210023, China; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, UCAS, Hangzhou, 310024, China.
Li J; State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China; School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Qixia District, Nanjing, 210023, China; Zhongshan Institute of Drug Discovery, Institution for Drug Discovery Innovation, Chinese Academy of Science, Zhongshan, 528400, China; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, UCAS, Hangzhou, 310024, China. Electronic address: .
Huang X; State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, UCAS, Hangzhou, 310024, China. Electronic address: .
Wang J; State Key Laboratory of Drug Research and CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China; University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing, 100049, China; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, UCAS, Hangzhou, 310024, China. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Oct 15; Vol. 222, pp. 113592. Date of Electronic Publication: 2021 Jun 05.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Enzyme Inhibitors/*pharmacology
Histone-Lysine N-Methyltransferase/*antagonists & inhibitors
Multiple Myeloma/*drug therapy
Naphthalenes/*pharmacology
Repressor Proteins/*antagonists & inhibitors
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Cell Cycle Checkpoints/drug effects ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Histone-Lysine N-Methyltransferase/metabolism ; Humans ; Molecular Structure ; Multiple Myeloma/metabolism ; Multiple Myeloma/pathology ; Naphthalenes/chemical synthesis ; Naphthalenes/chemistry ; Repressor Proteins/metabolism ; Structure-Activity Relationship ; Tumor Cells, Cultured
Czasopismo naukowe
Tytuł :
Synthesis and biological evaluation of chalcone-polyamine conjugates as novel vectorized agents in colorectal and prostate cancer chemotherapy.
Autorzy :
Rioux B; Université de Limoges, Laboratoire PEIRENE EA 7500, Faculté de Pharmacie, 2 Rue Du Dr Marcland, 87025, Limoges Cedex, France.
Pinon A; Université de Limoges, Laboratoire PEIRENE EA 7500, Faculté de Pharmacie, 2 Rue Du Dr Marcland, 87025, Limoges Cedex, France.
Gamond A; Université de Limoges, Laboratoire PEIRENE EA 7500, Faculté de Pharmacie, 2 Rue Du Dr Marcland, 87025, Limoges Cedex, France.
Martin F; Université de Limoges, Laboratoire PEIRENE EA 7500, Faculté de Pharmacie, 2 Rue Du Dr Marcland, 87025, Limoges Cedex, France.
Laurent A; Université de Limoges, Laboratoire PEIRENE EA 7500, Faculté de Pharmacie, 2 Rue Du Dr Marcland, 87025, Limoges Cedex, France.
Champavier Y; Université de Limoges, Laboratoire PEIRENE EA 7500, Faculté de Pharmacie, 2 Rue Du Dr Marcland, 87025, Limoges Cedex, France; Université de Limoges, BISCEm NMR Platform, GEIST, 2 Rue Du Dr Marcland, 87025, Limoges Cedex, France.
Barette C; Université Grenoble Alpes, CEA, INSERM, IRIG, BGE U1038, Genetics & Chemogenomics, 17 Avenue des Martyrs, Grenoble, 38054, France.
Liagre B; Université de Limoges, Laboratoire PEIRENE EA 7500, Faculté de Pharmacie, 2 Rue Du Dr Marcland, 87025, Limoges Cedex, France.
Fagnère C; Université de Limoges, Laboratoire PEIRENE EA 7500, Faculté de Pharmacie, 2 Rue Du Dr Marcland, 87025, Limoges Cedex, France.
Sol V; Université de Limoges, Laboratoire PEIRENE EA 7500, Faculté de Pharmacie, 2 Rue Du Dr Marcland, 87025, Limoges Cedex, France.
Pouget C; Université de Limoges, Laboratoire PEIRENE EA 7500, Faculté de Pharmacie, 2 Rue Du Dr Marcland, 87025, Limoges Cedex, France. Electronic address: .
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Źródło :
European journal of medicinal chemistry [Eur J Med Chem] 2021 Oct 15; Vol. 222, pp. 113586. Date of Electronic Publication: 2021 May 28.
Typ publikacji :
Journal Article
MeSH Terms :
Antineoplastic Agents/*pharmacology
Chalcone/*pharmacology
Colorectal Neoplasms/*drug therapy
Polyamines/*pharmacology
Prostatic Neoplasms/*drug therapy
Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Cell Cycle/drug effects ; Cell Proliferation/drug effects ; Chalcone/chemistry ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Male ; Models, Molecular ; Molecular Structure ; Polyamines/chemistry ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology ; Structure-Activity Relationship ; Tumor Cells, Cultured
Czasopismo naukowe

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